PCT - World Oral Care Formulation Patents Published in 2009

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PCT - WORLD PATENTS IN ORAL CARE PUBLISHED IN 2009


Title: COMPOSITION AND METHOD FOR ENHANCING FLOURIDE UPTAKE USING BIOACTIVE GLASS

Publication No: WO2009/158564
Pub. Date - Int. Class - Applicant: - 30.12.2009 - A61K 8/02 - NOVAMIN TECHNOLOGY, INC.
A method for increasing fluoride uptake onto a tooth structure of a patient comprises contacting the tooth structure with an oral care composition, which comprises bioactive glass and fluoride. The oral care composition has the following formulation:


Title: USE OF ZINC CHELATORS TO INHIBIT BIOFILM FORMATION

Publication No: WO2009/155088
Pub. Date - Int. Class - Applicant: - 23.12.2009 - A01N 37/00 - UNIVERSITY OF CINCINNATI
A method is provided for inhibiting formation of a biofilm of bacteria, the method including contacting the bacteria with an effective amount of at least one zinc chelator, wherein the bacteria contain at least one zinc adhesion module, whereby formation of the biofilm is inhibited. A method for inhibiting biofilm formation on a device and a topical pharmaceutical composition for the inhibition of biofilm formation are also provided.


Title: DEVICE FOR DISPENSING A DENTAL COMPOSITION

Publication No: WO2009/154871
Pub. Date - Int. Class - Applicant: - 23.12.2009 - A61M 5/30 - 3M INNOVATIVE PROPERTIES COMPANY
A device for dispensing a dental composition is provided. The device comprises a plunger for extruding dental composition from a container, an energy accumulator for advancing the plunger, and an actuator for charging the energy accumulator. The force for actuating the actuator is lower than the force at which the plunger can be advanced. The device preferably provides convenient dispensation of dental compositions.


Title: A POLYMER ADAPTED TO RELEASE BIOACTIVE AGENTS IN VIVO, PHARMACEUTICAL COMPOSITION AND METHOD OF PREPARATION THEREOF

Publication No: WO2009/153784
Pub. Date - Int. Class - Applicant: - 23.12.2009 - G01N 33/86 - Z.H.T. ENGINEERING EQUIPMENT AND TECHNOLOGIES LTD
The present onvention provides a Monodisperse Polymer Particles (MPP) adapted to release alkoxy groups by means of a hydrolyser, such that Monodisperse Bioactive Polymer Particles (MBPP) are obtained in vivo. The MBPP are characterized by (a) at least one naturally occurring or synthetic long molecular chain consisting of biologically stable backbones optionally crosslinked, further characterized by a molecular weight of at least 1 KD, comprising between 10 to 1,000,000 repeated covalently-linked small molecules with a functionality of at least one alkoxy releasing group per molecule; (b) a long dimension between 0.1 and 10 micrometers; and, (c) a zeta potential value of 30 to 130 mV at pH of about 7.0. The MBPP alter, inhibit, activate, in...


Title: CAPILLARY PLATE AND METHOD FOR GROWTH AND ANALYSIS OF MACROMOLECULAR CRYSTALS

Publication No: WO2009/153163
Pub. Date - Int. Class - Applicant: - 23.12.2009 - B01L 3/06 - UNIVERSITÄT ZÜRICH
The present invention relates to a capillary plate and to a method for growing macromolecular crystals using said capillary plate. The capillary plate allows proteins and other macromolecules to be crystallized by the counter-diffusion method in a restricted geometry. Using this procedure, crystals can be adequately prepared for direct X-ray data analysis such that the macromolecule's three-dimensional structure can be solved without crystal manipulation.


Title: ORAL COMPOSITIONS AND USES THEREOF

Publication No: WO2009/152507
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 8/03 - COLGATE-PALMOLIVE COMPANY
The present invention is directed to a dual phase mouth wash composition comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, and methods of use thereof. The hydrophilic and hydrophobic phases remain separated and form a temporary emulsion when mixed. The emulsion spontaneously reverts back to the two original phases after rest, without the formation of a emulsion.


Title: USE OF HYDROGEN PEROXIDE-PRODUCING BACTERIA FOR TOOTH WHITENING

Publication No: WO2009/152331
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 6/00 - ORAGENICS, INC.
The invention provides compositions and methods for whitening teeth of a subject comprising administering one or more isolated, non-pathogenic, hydrogen peroxide-producing bacterial strains to an oral cavity of a subject.


Title: INITIATOR SYSTEM WITH BIPHENYLENE DERIVATES, METHOD OF PRODUCTION AND USE THEREOF

Publication No: WO2009/152211
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 6/00 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to an initiator system comprising (a) an iodonium salt, (b) a light sensitizer and (c) an electron donor compound comprising a biphenylene structure, the biphenylene structure comprising at least one but not more than about 4 alkyl groups. The invention also relates to a hardenable composition comprising such an initiator system and the use thereof, as well as to a process for producing the substituted biphenylene compound.


Title: STANNOUS CHLORIDE COMPOSITIONS

Publication No: WO2009/151986
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 8/02 - THE PROCTER &GAMBLE COMPANY
The invention relates to a particulate composition comprising: c) a particulate source of stannous chloride; d and silicon dioxide (also referred to as hydrated silica or silica). The invention further relates to a method for improving the flowability of particulate stannous chloride by admixing silica with it. The composition of the invention has been found to give improved flow properties to stannous chloride when compared to the absence of an anti-caking agent, as assessed via methods of powder characterisation detailed in the European Pharmacopoeia.


Title: A DEVICE AND A METHOD FOR DELIVERY OF A DENTAL COMPOSITION

Publication No: WO2009/151983
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61M 5/30 - 3M INNOVATIVE PROPERTIES COMPANY
A device for use in retracting a gingiva from a human tooth by widening a gingival sulcus with a dental composition. The device comprises a cannula with a free end having an opening for dispensing the dental composition. The free end is shaped to be inserted with its front in the entry of the gingival sulcus, and to laterally displace the gingiva from the tooth as the cannula is moved in the gingival sulcus. The invention may help to achieve a reliable and cost effective gingival retraction treatment.


Title: INITIATOR SYSTEM CONTAINING A DIARYLAKYLAMINE DERIVATIVE, HARDENABLE COMPOSITION AND USE THEREOF

Publication No: WO2009/151957
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 6/00 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to an initiator system comprising a diarylalkylamine compound and a sensitizing agent. The invention also relates to a hardenable composition comprising the initiator system. The invention further relates to the use of the initiator system for initiating the hardening process of a hardenable composition being selected from cationically curing composition(s) and/or radically curing composition(s) or a mixture thereof. The initiator system and the hardening composition can be used in various fields, including the dental and orthodontic area.


Title: BIOCOMPATIBLE ADHERENT SHEET FOR TISSUE SEALING

Publication No: WO2009/151414
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61L 15/28 - ENDOMEDIX, INC.
A biocompatible adherent sheet for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The biocompatible adherent sheet includes a carrier sheet including a biocompatible polymer and a modified chitosan evenly disposed on one or both sides of the carrier sheet. Methods of preparing a biocompatible adherent sheet and methods of using a biocompatible adherent sheet are also provided. The biocompatible adherent sheet may also include a bioactive agent.


Title: BIOCOMPATIBLE MATERIALS FOR MAMMALIAN STEM CELL GROWTH AND DIFFERENTIATION

Publication No: WO2009/150051
Pub. Date - Int. Class - Applicant: - 17.12.2009 - C12M 3/00 - AARHUS UNIVERSITET
A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.


Title: POWDER JET DEVICE FOR APPLYING DENTAL MATERIAL

Publication No: WO2009/148907
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61C 3/025 - 3M INNOVATIVE PROPERTIES COMPANY
A nozzle head (5) for a powder jet device (1), for use in applying dental material, comprises a first fluid flow path (8) for delivering a powder/fluid mixture to a first discharge nozzle (8A). A second fluid flow path (6) is provided for delivering a liquid to a second discharge nozzle (6A) located adjacent the first discharge nozzle (8A), so that the materials discharged by the first and second discharge nozzles combine at a desired location to form a dental composition. A nozzle-clearing member (10) is located inside the nozzle head and is movable to remove powder material from the first discharge nozzle when the flow of powder/fluid mixture to the nozzle ceases.


Title: ORAL COMPOSITIONS CONTAINING ENHANCED ANTIBACTERIAL COMBINATIONS OF ANTIOXIDANTS AND EXTRACTS OF MAGNOLIA

Publication No: WO2009/148875
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61K 31/05 - WM. WRIGLEY JR. COMPANY
An oral composition contains an enhanced antibacterial effective amount of an antioxidant and an extract of Magnolia.


Title: MIXER FOR MIXING A DENTAL COMPOSITION

Publication No: WO2009/148785
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61C 5/06 - 3M INNOVATIVE PROPERTIES COMPANY
A mixer for mixing a dental composition comprises a mixer housing with a wall of the mixer housing forming a light filter. The light filter provides for substantially blocking light of certain wavelengths, whereas it transmits light of at least some other wavelengths. The invention may help to prevent dental compositions from degrading.


Title: INTEGRATED PORCELAIN SYSTEM FOR A DENTAL PROSTHESIS

Publication No: WO2009/148558
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61K 6/027 - DENTSPLY INTERNATIONAL INC.
An integrated dental porcelain system for making dental prostheses and restorations is provided. The system includes three universal major components: a) opaque porcelain composition; b) pressable dentin ingot; and c) veneering porcelain composition that can be used interchangeably for making restorations. Techniques for making the prostheses and restorations include porcelain fused-to-metal (PFM), press-to-metal (PTM), and either pressed and/or machined all-ceramic methods. The system uses both a hand-layering of veneering porcelain (PFM technique) and a hot-pressing process (PTM and all-ceramic technique) to fabricate the prostheses and restorations.


Title: CHEWY TOOTHBRUSH, TONGUE CLEANER AND APPLICATOR

Publication No: WO2009/146481
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61C 17/00 - WHITE, Maurice
The object of the invention is a chewable elastic, compressible, resilient elastomer or rubber block or strip of suitable shapes that force dental agents like toothpaste inside pits and fissures and between teeth under chewing pressure, which can also be part of a toothbrush with added features such as peaks or walls that act as a tongue and soft tissue cleaner. It is also an object of this invention to force fillings or fissure sealants into pits and fissures or selected parts of one or more opposing occlusal surfaces to maintain tooth shape and prevent food being trapped and changed to acid.


Title: NATURAL ANTIGINGIVITIS AND ANTIPLAQUE MOUTH RINSES, AND METHODS OF USE THEREOF

Publication No: WO2009/146124
Pub. Date - Int. Class - Applicant: - 03.12.2009 - A61K 8/97 - THE NATURAL DENTIST
One aspect of the invention relates to an anti-gingivitis or anti-plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine. Another aspect of the invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine. Another aspect of the invention relates to treating and/or preventing one or more of dental caries, oral micr...


Title: NOVEL MONOMER FOR DENTAL COMPOSITIONS

Publication No: WO2009/146067
Pub. Date - Int. Class - Applicant: - 03.12.2009 - C07C 235/70 - UNIVERSITY OF KANSAS
A novel monomer, 1,1,1-tri-[4-(methacryloxyethylaminocarbonyloxy)-phenyl] ethane (MPE) can be used in preparing dental compositions The MPE monomer can be combined into a dental adhesive with hydroxyethyl methacrylate (HEMA) and BisGMA (bisphenol A dimethacrylate). The MPE polymer can be polymerized with a photoinitiator system, such as a system that includes an iodonium salt. The iodonium salt can be diphenyliodonium hexafluorophosphate.


Title: OSTEOINDUCTIVE NANOCOMPOSITES

Publication No: WO2009/145630
Pub. Date - Int. Class - Applicant: - 03.12.2009 - A61L 27/46 - REVISIOS B.V. I.O.
The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c. adding polymers (previously dissolved in an organic solvent) to calcium phosphate nanocrystal suspension, rotational mixing of the components using beads...


Title: FOOD PRODUCT

Publication No: WO2009/144458
Pub. Date - Int. Class - Applicant: - 03.12.2009 - A23L 1/00 - MARS, INCORPORATED
The present invention relates to a food product comprising an outer portion and an inner portion, wherein the inner portion comprises myrtle and has a moisture content of from about 10% to about 25% by weight, the food product for use in oral health applications, and the use of the food product in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of tartar and/ or dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes the food product for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal.


Title: HYPOXIA INDUCING FACTOR (HIF) STABILISING GLASSES

Publication No: WO2009/144453
Pub. Date - Int. Class - Applicant: - 03.12.2009 - A61F 2/00 - IMPERIAL INNOVATIONS LIMITED
The present invention relates to a glass composition formulated to provide the controlled release of certain transition metal ions to regulate the cellular hypoxia pathway and the use of these hypoxia-pathway regulating glasses in medicine and in biomedical research, including in the repair, restoration or regeneration of diseased or damaged tissue.


Title: DENTAL COMPOSITION CONTAINING ORGANIC NANOTUBE

Publication No: WO2009/142340
Pub. Date - Int. Class - Applicant: - 26.11.2009 - A61K 6/08 - VERICOM CO., LTD.
Disclosed is a dental composition, comprising unsaturated double bond-containing monomers and/or oligomers, a catalytic amount of polymerization initiator to initiate polymerization, and a filler, wherein the dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material to inhibit or prevent tooth decay. The dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material, thus uniformly and continuously exhibiting anticariogenic and antibacterial activities, while avoiding deterioration in physical properties required for the dental material.


Title: FOAMABLE COMPOSITIONS FOR DENTAL COATINGS AND METHODS

Publication No: WO2009/140334
Pub. Date - Int. Class - Applicant: - 19.11.2009 - A61Q 11/00 - 3M INNOVATIVE PROPERTIES COMPANY
A foamable dental composition that includes a film- forming component and a non-aqueous carrier comprising a co-solvent selected from the group consisting of diethylene glycol monoethyl ether, dipropylene glycol, 200 to 45,000 molecular weight poly(ethylene glycol), methoxides of 200 to 45,000 molecular weight poly(ethylene glycol), hexamethyldisiloxane, and a combination thereof, wherein the film-forming component is dissolved in the carrier; wherein the film-forming component forms a retentive polymeric coating on a dental surface; and a method of forming a retentive polymeric coating on the dental surface are disclosed.


Title: APPARATUS AND METHODS FOR ROOT CANAL TREATMENTS

Publication No: WO2009/137815
Pub. Date - Int. Class - Applicant: - 12.11.2009 - A61C 5/02 - DENTATEK CORPORATION
Apparatus and methods for root canal treatments are provided. In some embodiments, an aiming element may be used to position a high-velocity liquid jet near a desired location in the tooth. Embodiments of the aiming element may include an interrupter that deflects or impedes the liquid jet when it is not desirable for the jet to propagate from the aiming element. Embodiments of the aiming element may include an elongated member that permits passage of the liquid jet through a channel. The elongated member may include one or more openings, for example, on sides and/or ends of the member. Some root canal cleaning techniques include one or more applications of the liquid jet followed by application of a disinfectant such as. for example, an aq...


Title: NOVEL CROSSLINKED POLYMERIC SUBSTRATES METHODS OF PREPARATION AND END USE APPLICATIONS OF THE SUBSTRATES

Publication No: WO2009/137046
Pub. Date - Int. Class - Applicant: - 12.11.2009 - C08K 5/541 - CAPTUR TECHNOLOGIES, LLC
A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting essentially of a water soluble polymer, a water soluble copolymer, an alcohol soluble polymer, an alcohol soluble copolymer, and combinations of such polymers, wherein the polymer is chemically bonded to the siliceous substrate by a silane linking material having the general formula O3/2SiQY that is derived from an alkoxy-functional silane having the general formula (RO)3SiQX and processes for preparing the crosslinked polymer that is chemically bonded to the surface of the siliceous substrate.


Title: TOPICAL COMPOSITIONS

Publication No: WO2009/136179
Pub. Date - Int. Class - Applicant: - 12.11.2009 - A61K 9/06 - OMEGATRI AS
A topical composition e.g. pharmaceutical or cosmetic composition comprising at least one cyclodextrin complex of a marine unsaturated fatty acid or derivative thereof wherein the weight ratio of cyclodextrin to marine fatty acid or derivative thereof is between 1:10 10:1.


Title: INSTRUMENT CLEANER

Publication No: WO2009/135259
Pub. Date - Int. Class - Applicant: - 12.11.2009 - C11D 7/26 - NOVAPHARM RESEARCH (AUSTRALIA) PTY LTD
A composition or concentrate for cleaning medical or dental instruments comprising in combination a protease and a biostatically effective phenoxy alcohol such as phenoxyethanol selected such that at a working solution dilution of the combination, the phenoxy alcohol is at a concentration below the MIC of the selected phenoxy alcohol against Pseudomonas aeruginosa (ATCC 15442), and wherein the combination is nevertheless effective to reduce a 6 log concentration of Pseudomonas aeruginosa (ATCC 15442) by at least a 1 log concentration within 4 hours. The composition or concentrate may further include or more hydrolases and or boron or a boron compound. The composition may be used in methods for cleaning a soiled medical or dental instrument,...


Title: POLYMER-FREE DRUG DELIVERY SYSTEM FOR IMPLANTABLE MEDICAL DEVICES

Publication No: WO2009/132411
Pub. Date - Int. Class - Applicant: - 05.11.2009 - A61L 27/56 - THE UNIVERSITY OF BRITISH COLUMBIA
Disclosed herein are methods of making polymer-free drug delivery systems for implantable medical devices, as well as devices made by employing such method. A method of making a polymer-free bioactive agent delivery system for an implantable medical device comprising: (a) emulsifying a bioactive agent in a solvent to produce emulsified droplets; and (b) loading the emulsified droplets bearing the bioactive agent into a porous carrier for delayed delivery.


Title: OUTER LAYER MATERIAL HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST BLENDED WITH A MALEATED HYDROPHOBIC POLYMER CO-HOST, AND HYDROPHILIC POLYMER GUEST

Publication No: WO2009/131983
Pub. Date - Int. Class - Applicant: - 29.10.2009 - C08J 7/04 - COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary ...


Title: ORAL CARE COMPOSITION CONTAINING OXIDASE ENZYME

Publication No: WO2009/131799
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61Q 11/00 - DANISCO US INC., GENENCOR DIVISION
Oral care compositions comprising an oxidase, polyethyleneimine, and an orally acceptable carrier are described, along with methods of use thereof. The oral care composition may be applied to a tooth surface to produce peroxide.


Title: DRUG RELEASE COASTINGS ON CALCIUM PHOSPHATE AND USES THEREOF

Publication No: WO2009/131638
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61F 2/02 - YESHIVA UNIVERSITY
The invention provides implantable drug releasing materials comprising a calcium phosphate composition, a biodegradable polymer adsorbed onto the calcium phosphate composition, wherein the polymer comprises acidic amino acid residues, and a drug adsorbed onto or reacted with the polymer. The invention is further directed to dental and bone implants and implantable medical devices comprising the implantable drug releasing material, methods for preparing the implantable drug releasing material, and methods for delivering the implantable drug releasing material to bone or teeth.


Title: IMPROVEMENTS TO SOLUTION AND METHOD FOR CLEANING TOOTH ENAMEL

Publication No: WO2009/131431
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61K 8/20 - ALFARO CASTA�EDA, José Fernando
The invention relates to a solution with a concentration of 6N of HCL, C6 O7 H8, citric acid and water demineralised by reverse osmosis and bacterially purified by ozonisation and lemon-flavoured artificial liquid essence or anise-flavoured artificial liquid essence and water demineralised by reverse osmosis and bacterially purified by ozonisation, and to a method for using same to dissolve the brown pigmentation of teeth affected by problems of mottled enamel or chronic endemic dental fluorosis, as well as teeth with white, opaque or yellow stains. The composition is applied to the surface of the part to be treated using a small cotton swab secured with ...


Title: ELECTRIC BIDIRECTIONAL ROTATION REVERSIBLE TOOTHBRUSH WITH SPEED REDUCING CASE

Publication No: WO2009/130678
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61C 17/26 - GONZALEZ ULLOA, Rafael
This invention is related to an electric brush that provides a correct, harmless and easy brushing for the human oral health and cleaning, it also may be used in the therapeutic hygiene of handicapped persons and even in veterinary use for related animals. It has reloadable batteries. It includes a reversible electric motor, a reducer gear cage, a cylindrical or conic brush with special bristles in all its surface (360°), a cabling and electric switches of 3 position that achieves a complete EFFICIENT ROTATION of the brush in 2 directions manually changeable, one of them clockwise and the other one counterclockwise to make the brushing of the teeth in the right direction required and recommended by the dentists for the gums of each maxil...


Title: REMINERALISATION OF CALCIFIED TISSUE

Publication No: WO2009/130447
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61K 6/06 - THE UNIVERSITY OF DUNDEE
The disclosure concerns cosmetic and therapeutic treatment of tissue, such as tooth, to effect, for instance, whitening and tissue re-building through mineralisation and including kits for use in said methods.


Title: ORAL CARE COMPOSITION COMPRISING DISSOLVED TIN AND FLUORIDE

Publication No: WO2009/130319
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61K 8/19 - GABA INTERNATIONAL AG
An oral care composition comprising a liquid phase containing 30% to 90%, preferably 30% to 80% by weight, based on the liquid phase, of water; dissolved tin; 200 to 2000 ppm fluoride ions, based on the oral composition; and 5 to 60% by weight, based on the oral care composition, of a C(3-5) sugar alcohol; characterised in that the content of dissolved tin [Sn] in the liquid phase is at least 750 ppm, preferably at least 1000 ppm, based on the composition; that 60 mol% or more, preferably 75 mol% or more of the content of dissolved tin [Sn] is in the formal oxidation state +II; and that the composition comprises an organic acid and ammonium cations of the Formula (I) : R-NH+R
Title: ANTIFUNGAL AND ANTI-CARIOGENIC CELLOBIO-OLIGOSACCHARIDES PRODUCED BY DEXTRANSUCRASE

Publication No: WO2009/129525
Pub. Date - Int. Class - Applicant: - 22.10.2009 - A61K 31/702 - BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Cellobio-oligosaccharides (CBO) produced by the dextransucrase-catalyzed transglycosylation reaction of sucrose and cellobiose were discovered to be effective as antifungal agents against dental caries and against fungi who rely on glucan as an integral part of the cell wall, e.g., A. terreus. The cellobio-oligosaccharides were found to be inhibitors of ?-(l,3)-glucan synthase, an important enzyme involving in fungal cell wall component synthesis. The CBO caused structural changes in the growing fungal cells. In addition, the CBO were shown to be effective as anti-cariogenic agents in preventing bacterial adherence to teeth by inhibiting the formation of the bacterial plaque (glucans), e.g., that formed by <...


Title: DENTAL FILLING COMPOSITION COMPRISING HYPERBRANCHED COMPOUND

Publication No: WO2009/129359
Pub. Date - Int. Class - Applicant: - 22.10.2009 - A61K 6/00 - 3M INNOVATIVE PROPERTIES COMPANY
Compositions comprising a hyperbranched compound and a polymer prepared from reactants comprising at least one (meth)acrylate monomer, and dental filling compositions comprising a hyperbranched compound.


Title: DENTAL FILLING COMPOSITION COMPRISING ACIDIC POLYMER COMPOUND AND METHOD OF USING THE SAME

Publication No: WO2009/129074
Pub. Date - Int. Class - Applicant: - 22.10.2009 - C08L 33/08 - 3M INNOVATIVE PROPERTIES COMPANY
Compositions comprising an acidic polymer compound and a (meth)acrylic copolymer prepared from reactants comprising at least one aliphatic, aromatic, or aralkyl (meth)acrylate monomer and at least one ethylenically unsaturated monomer having a polar group or a siloxane group, and dental filling compositions comprising the composition, and methods of using the compositions


Title: MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION

Publication No: WO2009/127230
Pub. Date - Int. Class - Applicant: - 22.10.2009 - C12N 15/85 - CUREVAC GMBH
The present invention relates to a modified (m)RNA suitable for suppressing and/or avoiding an innate immunostimulatory response in a mammal typically exhibited when administering the corresponding unmodified (m)RNA and an immunosuppressive composition comprising this RNA. The invention furthermore relates to a pharmaceutical composition containing said modified (m)RNA. The invention also relates to the use of said modified (m)RNA or immunosuppressive composition (for the preparation of a medicament, e.g. a pharmaceutical composition) and/or the use of the pharmaceutical composition for suppressing and/or avoiding an immune response in a mammal when administering said pharmaceutical composition for the treatment of various diseases. Finally...


Title: COLLECTIVE KIT OF STORAGE AND ORGANIZATION OF PRODUCTS FOR ORAL HYGIENE

Publication No: WO2009/127022
Pub. Date - Int. Class - Applicant: - 22.10.2009 - A61C 19/02 - VILHEMA, Fabiano, Vieira
Collective kit of storage and organization of products for oral hygiene, especially of a kit (K) manufactured by means of injection in bio- plastic, containing basically a compact support (1) with lateral projections (2) for its fixation in the vertical position and brims (3) which facilitate the handling of the same; also having multiuse orifices (4) and rip (5) with uniform dimensions; said kit (K) has brush box (6) and liquid dentifrice tube - 'drop technique' (7) with bolts (8), could contain other supplies, as, for instance, boxes for dental floss equally endowed of bolts (8).


Title: ALPHA-GLUCANASE AND ORAL CARE COMPOSITION CONTAINING THE SAME

Publication No: WO2009/126773
Pub. Date - Int. Class - Applicant: - 15.10.2009 - A61Q 11/00 - DANISCO US INC., GENENCOR DIVISION
Isolated ?-glucanases from Hypocrea tawa, Trichoderma reesei, and Trichoderma konilangbra are described, as well as oral care compositions containing the same. The oral care composition may be employed to prevent or reduce dental plaque.


Title: COMPOSITIONS FOR HUMAN DENTAL CARE

Publication No: WO2009/126318
Pub. Date - Int. Class - Applicant: - 15.10.2009 - A61K 8/66 - ALBERT, Karen, L.
Compositions of the invention are water-based formulas that contain natural ingredients which aid in reduction of bacteria in the mouth, thereby reducing plaque and the production of tartar, and in one aspect of the invention are formulated as potable dental water that may be consumed in place of regular consumption of other forms of water or liquid, and in another aspect of the invention are formulated as dentifrices, such as toothpaste.


Title: LITHIUM SILICATE GLASS CERAMIC AND METHOD FOR FABRICATION OF DENTAL APPLIANCES

Publication No: WO2009/126317
Pub. Date - Int. Class - Applicant: - 15.10.2009 - C03C 3/085 - JAMES R. GLIDEWELL DENTAL CERAMICS, INC.
The present invention relates to preparing an improved lithium silicate glass ceramic for the manufacture of blocks for dental appliance fabrication using a CAD/CAM process. The lithium silicate material has a chemical composition that is different from those reported in the prior art including 8 to 10% of germanium dioxide in the final composition. The softening points are close to the crystallization final temperature of 83O0C indicating that the samples will support the temperature process without shape deformation. The resulting material has improved castability and higher density.


Title: DENTAL HYGYENE-BRUSHING CONSTRUCTION

Publication No: WO2009/125448
Pub. Date - Int. Class - Applicant: - 15.10.2009 - A46B 7/04 - DENTAL CLEANING S.R.L.
A brushing construction, particularly for oral or dental hygiene, comprises a brushing head which is removably coupled to a handle by a screw engagement means, the brushing head including a brushing head body having a threaded seat and a lug on which are engaged a plurality of brushing bristles arranged according to a spiral or spoke arrangement in either a cylindric or conic configuration; said brushing head being adapted to be applied to an end portion of the handle by screwing the body on an end portion of the handle, which, to that end, comprises a thread adapted to be threadably engaged in the threaded seat of the brushing head body.


Title: DENTAL STEM CELL DIFFERENTIATION

Publication No: WO2009/124213
Pub. Date - Int. Class - Applicant: - 08.10.2009 - C12N 5/08 - THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Provided is a method of preparing an embryonic stem cell-like cell, a method of preparing an insulin-secreting cell or pancreatic beta-like cell, a method of preparing a chondrocyte-like cell, a method of preparing a myocyte-like cell, and a method of preparing a hair follicle-like cell. A composition comprising a dental stem cell and an insulin-secreting cell or a pancreatic beta-like cell is also provided. Further, a composition comprising (a) a dental stem cell and (b) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell is provided. Additionally provided is an insulin-secreting cell or a pancreatic beta-like cell differentiated from a dental stem cell. Further provided is a chondrocyte-like cell, a myocyte-like cel...


Title: VIBRATING COMPRESSIBLE DENTAL PLATE FOR CORRECTING MALOCCLUSION

Publication No: WO2009/123965
Pub. Date - Int. Class - Applicant: - 08.10.2009 - A61C 5/00 - RUBIN, Clinton, T.
A improved vibrating dental plate that allows accelerative forces in addition to vibrating forces to assist in remodeling is provided.


Title: A PHOTOSENSITISING COMPOSITION AND ITS USES

Publication No: WO2009/123575
Pub. Date - Int. Class - Applicant: - 08.10.2009 - A61K 41/00 - NATIONAL UNIVERSITY OF SINGAPORE
The present invention provides a photosensitising composition comprising a mixture of at least one oxygen carrier, at least one oxidising agent and at least one surfactant, and its uses. The ratio of the at least one oxygen carrier to the at least one oxidising agent to the at least one surfactant may be in the range of 50:40:10 to 80:19.8:0.2. The photosensitising composition may be used for treating and/or preventing conditions caused by microorganisms.


Title: PHARMACEUTICAL COMPOSITION AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF

Publication No: WO2009/122280
Pub. Date - Int. Class - Applicant: - 08.10.2009 - A61K 9/08 - SCIGLIANO, Guiseppe Augusto
A pharmaceutical composition comprises a diluted water solution containing hydrogen peroxide between about 1% and about 40%, at least a stabilizing compound comprised between about 0% and about 0.2% and at least synergizing compound comprised between about 0% and about 1.5% in weight.


Title: DENTAL COMPOSITION FOR TREATING PERI-IMLANTITIS

Publication No: WO2009/122252
Pub. Date - Int. Class - Applicant: - 08.10.2009 - None - ITALMED S.R.L.
A new composition for treating peri-implantitis, i.e. of bacterial inflammatory processes that occur in a bone tissue close to a dental implant, comprising at least one biocompatible acrylic resin, said or each acrylic resin permeable to water, but insoluble to water; an antibiotic mixture; an organic solvent that in use is adapted to gradually evaporate, such that said at least one resin forms a protective film that gradually releases said antibiotic mixture. The antibiotic mixture comprises piperacillin sodium and tazobactam sodium in a predetermined weight ratio. In particular, said or each acrylic resin is permeable to water, but insoluble to water, and ensures the permanence of the film in the mouth even if saliva is present and at the...


Title: DISPERSINBTM, 5-FLUOROURACIL, DEOXYRIBONUCLEASE I AND PROTEINASE K-BASED ANTIBIOFILM COMPOSITIONS AND USES THEREOF

Publication No: WO2009/121183
Pub. Date - Int. Class - Applicant: - 08.10.2009 - C12N 9/58 - KANE BIOTECH INC.
The present invention provides antibiofilm composition comprising two or more agents selected from the group consisting of DispersinBTM, 5-Fluorouracil, Deoxyribonuclease I and Proteinase K for preventing growth and proliferation of biofilm-embedded microorganisms in wound care, oral care, and disease-related infections and methods of treatment in mammals. The invention further provides methods for preparing medical devices, and wound care devices using an antibiofilm composition comprising two or more antimicrobial agents selected from the group consisting of DispersinBTM, 5-Fluorouracil, Deoxyribonuclease I and Proteinase K.


Title: ABRASIVE DENTAL FLOSS AND METHOD OF MAKING SAME

Publication No: WO2009/120994
Pub. Date - Int. Class - Applicant: - 01.10.2009 - A61C 15/04 - COLTEC INDUSTRIES INC.
Polytetrafluoroethylene (PTFE) flosses have abrasives added to the floss fiber that increase the abrasion to teeth surfaces, and thus result in a floss that provides enhanced cleaning of surfaces of teeth that face interstices between teeth. Floss fiber is formed by loading a PTFE resin with an abrasive filler. The PTFE resin and filler are processed to form a floss fiber with a surface that provide enhanced abrasion properties.


Title: ZIRCONIA COMPATIBLE DENTAL ALLOY COMPOSITION

Publication No: WO2009/120752
Pub. Date - Int. Class - Applicant: - 01.10.2009 - C22C 5/02 - THE ARGEN CORPORATION
A novel titanium-noble metal dental alloy suitable for use with zirconia compatible porcelains, dental devices formed from such an alloy and a method of forming a dental device using such an alloy are provided. Generally the titanium-noble metal alloy of the invention has a composition comprising up to about 75 wt % titanium and about 25 wt % of at least one noble metal, such that the alloy has a thermal expansion coefficient of from about 9 to 11 x 10-6 at 25-600 °C.


Title: CAD/CAM MILLING PROCESS FOR THE FABRICATION OF DENTAL DEVICES

Publication No: WO2009/120749
Pub. Date - Int. Class - Applicant: - 01.10.2009 - A61C 5/10 - THE ARGEN CORPORATION
A method for fabricating a dental device using an improved milling technique is provided. The method uses a process in which the desired coping is milled from blanks made of a mix of metal powders and a polymer binder prior to densification. The step of densification incorporates debinding and sintering with or without infiltration. The method takes advantage of the advances in CAD/CAM technology to compensate for the shrinkage inherent when using mixes of metal and polymer powder to ensure proper dimensions in the final dental device.


Title: INTEGRATED MODULAR DENTAL MEASURING APPARATUS AND METHOD FOR DENTURES

Publication No: WO2009/120312
Pub. Date - Int. Class - Applicant: - 01.10.2009 - A61C 9/00 - GLOBAL DENTAL IMPRESSION TRAYS, INC.
An integrated modular dental measuring apparatus (100) and method of use for producing edentulous dentures. The apparatus is a set of components including a lower dental tray (102) having a removable modular contact plate (106) with an upwardly extending shoulder (108) surrounding a tapered opening (120), a ball nut (122) retained in the tapered opening, and a post (124) adjustably secured to the ball nut. A modular striking plate (126) may be removably attached to an upper dental tray (104) or an integrated striking sector (178) on a bottom surface (130) of the upper dental tray (104) is utilized to accurately obtain an established occlusal vertical and centric relation positions. The contact plate (106) and striking plate (126) are each c...


Title: THE MACHINE FOR THE SUPPLY OF THE TOOTHPASTE BY WAY OF SPREADING THE SAME ON A TOOTHBRUSH

Publication No: WO2009/120160
Pub. Date - Int. Class - Applicant: - 01.10.2009 - G07F 11/52 - TETIKLI, Sedat
The invention relates to the supply machine (1) developed for use in the places other than the houses where the people eat, in the workplaces, shopping centers, schools, hospitals and in all the other similar crowded places or in the open spaces, which machine spreads the toothpaste on a toothbrush (17) under completely hygienic conditions and enables the toothbrush (4) with the toothpaste spread thereon to be taken and used only for once by the person in the ambience. (Figure 1)


Title: APPARATUS AND METHODS FOR PROVIDING DENTIFRICE ADVANCEMENT

Publication No: WO2009/117650
Pub. Date - Int. Class - Applicant: - 24.09.2009 - A61C 3/06 - ONESTEP PROPHY ANGLE LLC
According to various embodiments, a dental prophylaxis angle is provided that includes including a content lumen within the body, wherein the proximal end of the body is attachable to a concentric drive dental handpiece and the distal end of the body includes a denial tip and a content portal proximate the dental tip. The dental prophylaxis angle can also include a collapsible container disposed within the content lumen and in fluid communication with content portal. The dental prophylaxis angle can also include a reciprocating advancement mechanism including a gripping section slidably attached to an exterior surface of the body and at least one member extending through the body and into the content lumen in communication with the proximal...


Title: COMPOSITIONS COMPRISING NONIONIC AND ZWITTERIONIC SURFACTANTS

Publication No: WO2009/117643
Pub. Date - Int. Class - Applicant: - 24.09.2009 - A61K 8/44 - COLGATE-PALMOLIVE COMPANY
An foaming agent comprising a non-ionic surfactant, zwitterionic surfactant, and free of anionic surfactants which is suitable for use in personal care products, e.g., dentifrice compositions, e.g., for use in the treatment and/or alleviation of xerostomia.


Title: COMPOSITE IMPLANT HAVING POROUS STRUCTURE FILLED WITH BIODEGRADABLE ALLOY AND METHOD OF MAGNESIUM-BASED MANUFACTURING THE SAME

Publication No: WO2009/116799
Pub. Date - Int. Class - Applicant: - 24.09.2009 - A61F 2/28 - U &I CORPORATION
The present invention provides a composite implant comprising pores of a porous structure filled with a biodegradable magnesium-based alloy. Further, the present invention provides a composite implant which filles pores of the porous structure prepared by a metal, a ceramic or a polymer with a biodegradable magnesium-based alloy. Mechanical properties of the composite implant of the present invention are improved because a magnesium-based alloy filled in its pores increases the strength of a porous structure comprised of a metal, a ceramic or a polymer. Futher, it can be expected that the magnesium-based alloy filled in the porous structure is decomposed in a living body, thus increasing bone formation rate. Accordingly bone tissue can be r...


Title: WATER-BASED RESIN COMPOSITION AND ARTICLES MADE THEREFROM

Publication No: WO2009/114788
Pub. Date - Int. Class - Applicant: - 17.09.2009 - C08J 3/20 - ALLEGIANCE CORPORATION
An aqueous elastomer dispersion includes a dispersed phase and an aqueous phase. The dispersed phase includes an elastomer including curable aliphatic conjugated- diene elastomers, such as polyisoprene, and a minor amount of at least one additive. The aqueous phase includes water and other optional components in either a soluble state or a dispersion state. The aqueous elastomer dispersion may be prepared by dissolving an elastomer, such as rubber, and additives in a solvent mixture and then converting the resulting solution into an aqueous emulsion. The aqueous emulsion is concentrated and the solvent is stripped from it to yield a dilute latex. The dilute latex that is obtained is concentrated again. Articles made from the aqueous elastom...


Title: COMPOSITION CONTAINING A WATER-MISCIBLE LIQUID AND A WATER-SOLUBLE PARTICLE, METHOD OF PRODUCTION AND USE THEREOF

Publication No: WO2009/114581
Pub. Date - Int. Class - Applicant: - 17.09.2009 - A61K 8/04 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a water-soluble composition comprising a water miscible liquid and water-soluble particles, the water-soluble composition being essentially free of water. The composition can be used e.g. as dental composition, cleaning agent, polishing agent, tongue surface cleaning agent or peeling agent.


Title: CLEANING COMPOSITION

Publication No: WO2009/112843
Pub. Date - Int. Class - Applicant: - 17.09.2009 - C11D 3/00 - AMITY LIMITED
A cleaning and disinfecting composition comprises a long-chain alkyl polyamine, such as dodecyl dipropylene triamine; a long-chain quaternary ammonium salt, such as N,N-didecyl-N,N-dimethylammonium chloride; and a metal carbonate salt, such as potassium carbonate, all in aqueous solution. A sequestering agent, a long-chain alkyl polyethoxylate, an alkanolamine and an anti-corrosive agent may also be present. The composition has a pH at least 11 when diluted to an in-use concentration. It may be used to clean and disinfect hard surfaces, such as medical, dental and surgical implements, walls, floors, sinks and hard furnishing surfaces, or soft surfaces such as bedding, upholstery or clothing. The composition is effective as a virucide, a spo...


Title: DENTAL COMPOSITION FOR DESENSITIZING, DISINFECTING AND PROTECTING EXPOSED DENTINE

Publication No: WO2009/106972
Pub. Date - Int. Class - Applicant: - 03.09.2009 - A61Q 11/00 - ITALMED S.R.L.
A composition for desensitizing, disinfecting and protecting exposed dentine comprising a substance that causes the precipitation of a calcium- containing substance compound inside the dentinal tubules, in particular, oxalic acid, potassium oxalate or a fluorine salt, and an acrylic polymer (preferably 2-hydroxyethylmetacrylate) for stabilizing the precipitated calcium- containing substance. The composition has a higher efficiency than common use desensitizing substances because it assists adhesion of insoluble calcium oxalate and calcium fluoride crystals, deep inside the dentinal tubules, thus stabilizing the occlusion of the tubules. The presence of a disinfecting substance further improves the composition efficiency; in particular, cati...


Title: DENTAL COMPOSITION FOR PREVENTING AND TREATING STOMATITIS AND MOUTH ULCERS

Publication No: WO2009/106963
Pub. Date - Int. Class - Applicant: - 03.09.2009 - A61K 36/328 - ITALMED S.R.L.
A composition in form of mouthwash, topic gel, or toothpaste, for avoiding and treating stomatitis, ulcerations, lesions of continuity of the mouth lining. The composition comprises Myrrh resin as fluid extract and chloride or other soluble zinc salt; advantageously it comprises also a disinfecting substance preferably of cationic type, such as chlorhexidine gluconate, as well as a glycyrrhetic acid, for example 18-?-glycyrrhetic acid. The composition has a higher analgesic, anti-inflammatory and disinfecting capacity than the products frequently used for stomatitis and mouth lining ulcers, owing to a synergistic action of the disinfecting properties of the zinc ion, and the disinfecting and analgesic activity of the Myrrh resin, advantage...


Title: CYCLIC AMINO ACIDS FOR THE TREATMENT OF PAIN

Publication No: WO2009/105887
Pub. Date - Int. Class - Applicant: - 03.09.2009 - A61K 31/198 - PUIL, ERNEST
Compositions comprising cyclic ammo acids or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier. Said composition are for use in the treatment of pain. Pain includes both acute and chronic forms of pain. The preferred cyclic amino acid is 1-aminocyclobutane-1-carboxylic acid (ACBC).


Title: IMPROVED DENTAL MODEL BASEPLATE

Publication No: WO2009/105193
Pub. Date - Int. Class - Applicant: - 27.08.2009 - A61C 11/02 - VAN VALEY, Edwin, T.
A dental model baseplate for use in the manufacture of a working dental model. The baseplate includes a connector element to fix a dental model articulator. An apparatus includes a plate portion and an adapter portion extending from the plate portion, the adapter portion configured for connecting to a portion of the dental articulator


Title: METHODS AND COMPOSITIONS OF SPHINGOLIPID FOR PREVENTING AND TREATING MICROBIAL INFECTIONS

Publication No: WO2009/104963
Pub. Date - Int. Class - Applicant: - 27.08.2009 - A23J 7/00 - INNOPACT B.V.
The present invention relates to controlled release composition for preventing and/or treating microbial infectionsin the oral cavity of a subject, said composition comprising a controlled delivery matrix which matrix has releasably associated therewith an amount of between 0.000009 and 5 wt% of a sphingolipid, wherein the composition provides a sphingolipid-release-profile in the oral cavity of a subject, wherein said release-profile is maintained for between 15 seconds and 24 hours and wherein said release-profile provides for a concentration of said sphingolipid in the saliva of said subject of between 20 µmole/L and 250 µmole/L.


Title: HYBRID DENTAL POST SYSTEM

Publication No: WO2009/102958
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61C 5/08 - BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
A dental post system (100, 200) includes a core (104, 204) having an outer surface and a thermoplastic coating (108, 208) on the outer surface. The thermoplastic coating (108, 208) includes a flexible polymer having different material properties than the underlying supporting core (104, 204). Heat, bonding agents or other plasticizers adapt the thermoplastic coating (108, 208) for fitting into the shape of the drilled root canal while the rigid core (104, 204) is relatively unaffected. Methods include plasticizing the coating before inserting the dental post system into a tooth canal, bonding the coating, the core, the resin cement and the tooth canal, and re-plasticizing the coating or dissolving the coating after insertion and retrieving ...


Title: PET DENTAL HYGIENE PRODUCT

Publication No: WO2009/102935
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61D 5/00 - WEISS, Susan, Datz
An edible product for oral hygiene of a pet, the product being chewable by the pet to remove plaque, tartar and stain from the teeth of the pet and to reduce breath odor of the pet. The dental hygiene product includes a body formed of a first set of constituent components and a second set of constituent components, the first set of constituent components including abrasive components and one or more breath freshening components, the combination when chewed by the pet effecting the removal of plaque, tartar and stain and the inhibition of breath odor, the second set of constituent components including an abrasive component and one or more active components, the abrasive component when chewed by the pet effecting the removal of plaque, tartar...


Title: USE OF CATIONIC SURFACTANTS FOR THE PROTECTION AGAINST TOOTH EROSION

Publication No: WO2009/101115
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61Q 11/00 - LABORATORIOS MIRET, S.A.
This invention relates to a use of a composition for protecting oral cavity and teeth containing ethyl-N?-lauroyl-L-arginate HCI (LAE), a corresponding composition and a corresponding method for protecting teeth. Because of nearly epidemic incidence of dental erosion, there is a continuing need for improved products that provide protection against dental erosion. Hence, it is an object of the present invention to protect teeth against dental erosion. Surprisingly, it has been found that ethyl-N?-lauroyl-L-arginate HCI (LAE) and its salts attach to teeth and provide protection of teeth from erosion especially caused by the action of acid in food products and drinks such as chewing gum and lozenges compositions. Special advantages of this i...


Title: COMPOSITIONS CONTAINING CATIONICALLY SURFACE-MODIFIED MICROPARTICULATE CARRIER FOR BENEFIT AGENTS

Publication No: WO2009/100464
Pub. Date - Int. Class - Applicant: - 13.08.2009 - C11D 3/22 - AMCOL INTERNATIONAL CORPORATION
A coated microparticulate composition comprising a microparticulate; wherein the microparticulate comprises a benefit agent; and wherein the microparticulate is coated with: a Type-1 Polymer, wherein the Type-1 Polymer comprises a cationic polymer with a cationic atom content greater than about 3 wt. % and a weight average molecular weight less than about 800,000 Dalton; and a Type-2 Polymer, wherein the Type-2 Polymer comprises a cationic polymer with a cationic atom content less than about 3 wt. % and a weight average molecular weight greater than about 1,000,000 Dalton.


Title: ORAL CARE TOOTHBRUSH

Publication No: WO2009/100285
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A46B 9/04 - COLGATE-PALMOLIVE COMPANY
An oral care toothbrush includes a head mounted to one end of the handle containing a plurality of oral care elements. A dispenser for an oral care composition is mounted within the toothbrush. The oral care composition consists of arginine. The toothbrush is preferably made of small size and of lightweight so as to be readily portable for use away from the home.


Title: TOOTH SEALANT

Publication No: WO2009/100283
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 6/02 - COLGATE-PALMOLIVE COMPANY
The invention provides a method of treating sensitive teeth comprising attaching a sealant composition comprising a basic amino acid to a person's tooth and allowing the basic amino acid to be slowly released over time in order to reduce chrome and/or acute tooth sensitivity together with compositions and methods of use.


Title: CLEANING COMPOSITIONS AND METHODS

Publication No: WO2009/100281
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 8/44 - COLGATE-PALMOLIVE COMPANY
The present invention is directed to effervescent cleaning compositions comprising a basic amino acid.


Title: COMPOSITIONS AND DEVICES

Publication No: WO2009/100277
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 8/44 - COLGATE-PALMOLIVE COMPANY
The present invention prov ides tooth-whitening compositions comprising a bleaching agent and a baste amino acid, together with devices for application thereof, and methods of use therefor.


Title: DUAL COMPONENT ORAL CARE PRODUCT

Publication No: WO2009/100268
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 8/19 - COLGATE-PALMOLIVE COMPANY
A dental composition which, e.g., eliminates or substantially reduces the discomfort and pain associated with dentinal hypersensitivity and exhibits enhanced anticaries and remineralization benefits, which composition contains a first component containing a calcium source, a second component containing an anion source and at least one of the components containing a basic amino acid in free or salt form, and the first and second components being maintained separate from each other until dispensed and combined for application to teeth.


Title: DENTAL BONDING COMPOSITIONS AND METHODS USEFUL IN INHIBITION OF MICROLEAKAGE IN RESIN-BONDED DENTIN

Publication No: WO2009/099837
Pub. Date - Int. Class - Applicant: - 13.08.2009 - C08G 59/68 - THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Provided are methods and compositions relating to a dental bonding composition useful in bonding a dental resin composite. These methods include applying an etching composition comprising an etchant to a tooth to produce an etched dentin surface; applying a priming composition comprising a primer to the etched dentin surface; and applying an adhesive composition comprising a resin-based adhesive and a bioactive glass to the etched and primed dentin surface.


Title: FORMOCRESOL GEL

Publication No: WO2009/098710
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 6/00 - MAREDDY, Ajay, Reddy
Formocresol is a commonly used medicament in dentistry. The currently available fromocresol is of full strength and the international agency for cancer research as an affiliate of World Health Organisation recommends the use of minimum concentration of formaldehyde. This initiated us to do research to formulate a new gel form with minimum concentration of formaldehyde. We have done an in vitro study and our results have shown that this can be recommended as a medicament. We also found that the material is user friendly as it prevents formaldehyde vapour fumes while applying. The usage of 1-in-5 dilution of Buckley's formocresol is recommended is denistry, that does better in get form. The dilution should be performed in the local pharmacy t...


Title: DENTAL COMPOSITION FOR DESENSITIZATION AND DISINFECTION OF EXPOSED DENTIN

Publication No: WO2009/098531
Pub. Date - Int. Class - Applicant: - 13.08.2009 - A61K 6/00 - ITALMED S.R.L.
Dental composition for desensitization and disinfection of exposed dentin comprising a determined amount of a disinfectant, at least one soluble salt selected from the group comprised of : a soluble zinc salt, a soluble potassium salt, a soluble strontium salt, a combination thereof. In particular, the disinfectant is a cationic disinfectant selected from the group comprised of: benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, cetrimide, cetylpyridinium chloride, a combination thereof. The composition can be used replacing underlayers, or for desensitising and disinfecting treatment and replacing underlayers or for treatment of pillars at a prosthesis application for treatment of gingival withdrawal in consequence of u...


Title: DISPOSABLE PROPHY ANGLE WITH ENCOMPASSING INTEGRAL TOROIDAL PASTE POUCH FOR ATTACHING TO A DENTAL HANDPIECE

Publication No: WO2009/096914
Pub. Date - Int. Class - Applicant: - 06.08.2009 - A61C 1/10 - BALABAN, Elena
A dental cleaning attachment (10) for a dental handpiece (12) which comprises a disposable prophy angle (14) having a neck (16) and a right angle head (18), wherein the neck (16) is removably attached to the dental handpiece (12). A polishing cup (20) is rotatably connected to the head (18) of the prophy angle (14). An encompassing toroidal pouch (22) has a tube (24) fluidly formed to and extending from the toroidal pouch (22). The tube (24) runs externally along a top surface of the neck (26), is bent at a right angle, goes through a rear aperture in the head (28) of the prophy angle (14) and into a top aperture in the polishing cup (30). A paste material (32) is carried within the toroidal pouch (22), the tube (24) and the polishing cup (...


Title: TOOTHBRUSH INCLUDING A MIXED CARTRIDGE ENABLING AUTOMATIC INJECTION

Publication No: WO2009/096766
Pub. Date - Int. Class - Applicant: - 06.08.2009 - A46B 11/02 - LARA RODRÍGUEZ, Miguel
The invention relates to a toothbrush having a traditional shape, which is novel in that it includes a soft or hard exchangeable handle that supplies toothpaste and mouthwash in a single movement so that said dental care products reach the surface of the bristles following a single one-handed movement. The upper part of the brush contains an inner distribution channel which conveys the content to the bristles in such a way that the toothpaste supply system is automated.


Title: NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Publication No: WO2009/096701
Pub. Date - Int. Class - Applicant: - 06.08.2009 - C07C 311/45 - AMOREPACIFIC CORPORATION
This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present disclosure also provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.


Title: PHOTOLATENT AMIDINE BASES FOR REDOX CURING OF RADICALLY CURABLE FORMULATIONS

Publication No: WO2009/095282
Pub. Date - Int. Class - Applicant: - 06.08.2009 - C08F 2/50 - BASF SE
The invention pertains to photolatent amidine bases for redox curing of radically curable formulations, that is a composition comprising (a1) a photolatent amidine base; or (a2) a photolatent amine base; or (a3) a mixture of (a1) and (a2); and (b) a radically polymerizable compound; and (c) a free radical initiator capable to be reduced by amines and/or amidines, in particular a peroxide.


Title: JIG FOR FABRICATING DENTAL MODEL

Publication No: WO2009/093796
Pub. Date - Int. Class - Applicant: - 30.07.2009 - A61C 13/34 - CHO, Gwang Gi
The present invention relates to a jig for fabricating a dental model, which enables, when it is intended to fabricated a prosthesis for a damaged tooth, fabrication of a dental model from an impression mold of teeth of a patient, separating only a model of a damaged tooth from the dental model fabricated thus, and securing a renewal tooth of the damaged tooth to a required position. The jig includes a supporting member 100 having a base plate 110 for placing an impression material tray T thereon having an impression mold A seated thereon, a vertical plate 120 extended in up/down directions from a front edge of the base plate, and slots 121 formed on the same line in an upper edge and a lower edge of the vertical plate 120 and, a propping m...


Title: DEVICE FOR DEBRIDEMENT OF IMPLANTS, AND A METHOD FOR DEBRIDEMENT OF IMPLANTS USING THE DEVICE

Publication No: WO2009/092735
Pub. Date - Int. Class - Applicant: - 30.07.2009 - A61C 8/00 - LINDBERG IMPLANTS AB
A device (10) for debridement of dental implants, which are arranged into bone tissue and are surrounded by gingiva of a jaw of a human being, has a debriding element (11) and an axle (12) with a fastener (13) for attachment to a rotational apparatus The debriding element (11) has at least one cleaning leg (20) with at least one cutting edge for engagement with the implant, the gingiva and/or the bone tissue According to a second embodiment the debriding element has several portions each having said cleaning leg (20) and the portions are connected to each other Said cleaning leg (20) has a free end (21 ) shaped as a hook (30) with a point (31), which is provided with said cutting edge The device (10) may have several cleaning legs (20), eac...


Title: TONGUE RETRACTION AND CLEANING METHOD AND APPARATUS

Publication No: WO2009/091529
Pub. Date - Int. Class - Applicant: - 23.07.2009 - A61B 1/24 - METTLER, Gilbert, William, Jr.
One embodiment includes an apparatus for retracting an animal tongue that includes a handle that is elongate and that includes a proximal portion and a distal portion and a tongue receiving cup coupled to the distal portion of the handle, the tongue receiving cup being generally concave and sized such that a first side of the tongue receiving cup extends over a first side of the tongue, a second side opposite the first side extends over a second side of the tongue that is opposite the first side of the tongue, a dorsal portion of the cup extends along the dorsal portion of the tongue and a posterior extending tip extends at least partially along the back of the tongue, the first side, second side, and posterior extending tip defining a tong...


Title: CONTAINER HAVING MEANS FOR SANITISING AND PROTECTING A TOOTHBRUSH

Publication No: WO2009/087389
Pub. Date - Int. Class - Applicant: - 16.07.2009 - A47K 1/09 - SKOULDING, Richard
A toothbrush holder (1) comprises a container (2) defining a hollow body so sized and shaped as to accommodate a toothbrush. At one end of the body there is an open mouth into which a toothbrush may be placed and a closing cap for sealing the holder so that sanitising liquid held within the holder does not leak in transit. A platform element or cupped shuttle (5) receives the teeth-cleansing bristles carrying head of a toothbrush the shuttle being manually urged towards the base end of the cylindrical body against a biasing spring (4) to immerse the bristles (B) thereof into an amount of sanitising liquid (8). A closing cap is optionally provided at the base end of the holder to facilitate draining, cleaning, assembly and disassembly of the...


Title: ANALGESIC APATITIC CALCIUM-PHOSPHATE CEMENT

Publication No: WO2009/087148
Pub. Date - Int. Class - Applicant: - 16.07.2009 - A61L 27/54 - GRAFTYS
The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.


Title: DENTAL PROPHYLAXIS ANGLE HANDPIECE ASSEMBLY

Publication No: WO2009/085249
Pub. Date - Int. Class - Applicant: - 09.07.2009 - A61C 17/00 - DENTSPLY INTERNATIONAL INC.
A dental prophylaxis angle and handpiece assembly for cleaning and polishing teeth is provided. The dental prophylaxis angle is removably attached to the dental handpiece by an interlocking mechanism that includes extension locking tabs, a locking annular member, and an interlocking drive member in the handpiece. The prophy angle is securely snap-fitted onto the handpiece and locked in place so that it has minimal lateral movement. After the prophy angle has been used to treat a patient, it can be removed easily from the handpiece and disposed thereof.


Title: A MEDICAL CLEANING TOOL

Publication No: WO2009/083281
Pub. Date - Int. Class - Applicant: - 09.07.2009 - A46B 3/18 - NUMAT AS
The present invention relates to a medical cleaning tool (1) comprising an elongated base member (2) formed of at least two wires (3) being twisted with each other. In addition, the medical cleaning tool comprises a plurality of bristles (4) fixed between the twisted wires and extending away from the twisted wires, whereby the bristles are positioned in a cleaning section (5) at a first end (6) of the base member (2). The bristles consist of titanium or a titanium alloy.


Title: NOVEL CRYSTALLINE FORM C OF (2R)-(3-AMINO-2-FLUOROPROPYL)PHOSPHINIC ACID

Publication No: WO2009/082348
Pub. Date - Int. Class - Applicant: - 02.07.2009 - C07F 9/30 - ASTRAZENECA AB
The present invention relates to a novel crystalline form of (2R)-(3-amino-2- fluoropropyl)phosphinic acid, the present invention is also directed to the use of the crystalline form for the treatment of gast rointestinal disorders as well as to a pharmaceutical composition comprising the same and a process for the preparation of the crystalline form.


Title: RECEIVE STRUCTURE OF PORTABLE TOOTHPASTE

Publication No: WO2009/082144
Pub. Date - Int. Class - Applicant: - 02.07.2009 - A46B 17/00 - PARK, Young-sun
This present idea improves the organization, convenience, and sanitary conditions of conventional portable tooth brushes by equipping it with an additional storage room for toothpaste, dental floss, and proxabrush, which is partitioned by separate walls for each appliance with a one-touch lid for an easier access. Additionally, the construction of the lid allows the dental appliances to naturally dry off while stored.


Title: BIODEGRADABLE CONTRAST AGENTS

Publication No: WO2009/081169
Pub. Date - Int. Class - Applicant: - 02.07.2009 - A61K 49/04 - IOPHARMA TECHNOLOGIES AB
The present invention provides a radio-opaque composition comprising a cleavable, preferably enzymatically-cleavable, derivative of a physiologically tolerable organoiodine compound and a non-acrylic polymer wherein said derivative is incorporated in said non-acrylic polymer.


Title: DENTAL COMPOSITION CONTAINING A SURFACTANT AND AN F-CONTAINING COMPOUND, PROCESS OF PRODUCTION AND USE THEREOF

Publication No: WO2009/079534
Pub. Date - Int. Class - Applicant: - 25.06.2009 - A61K 6/083 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a curable dental composition comprising a) a curable organopolysiloxane polymer, b) a crosslinker compound capable of crosslinking said organopolysiloxane polymer, c) a catalyst capable of catalyzing a crosslinking reaction of component (A) and component (B), d) a surfactant, e) a F-containing compound, wherein the F-containing compound has the following formula: (G1-L1-O)s-Rfa-O-L2-G2 wherein: G1 and G2 each independently represents a non-ionic endgroup that is free of polyoxyalkylene groups or contains polyoxyalkylene such that the total amount thereof in the F-containing compound is not more than 10% by weight based on the molecular weight of the F-containing ompound; L1 and L2 each independently represents an al...


Title: ANTIMICROBIAL FILLED CAPSULES IN AN ULTRASOUND FIELD FOR TREATMENT OF DENTAL BIOFILM

Publication No: WO2009/077921
Pub. Date - Int. Class - Applicant: - 25.06.2009 - A61C 17/20 - KONINKLIJKE PHILIPS ELECTRONICS, N.V.
An appliance and corresponding method for delivering antimicrobial agents to the vicinity of dental biofilm and for killing bacteria therein includes a system (18, 20, 24) for delivering polymeric capsules containing gas bubbles and an antimicrobial agent. A source of ultrasonic energy (18) is provided for moving the capsules toward the biofilm, the ultrasonic energy having sufficient intensity for thereafter bursting the capsules, in the vicinity of the biofilm, releasing the gas bubbles and the agent. The gas bubbles vibrate within the ultrasound field, disrupting the biofilm, so that the released agent can act effectively against the bacteria in the disrupted biofilm.


Title: HARDENING COMPOSITION

Publication No: WO2009/077113
Pub. Date - Int. Class - Applicant: - 25.06.2009 - A61K 6/083 - DENTSPLY DETREY GMBH
A hardening composition comprising a particulate glass, said glass comprising 10-35% by weight of silica, 10-35% by weight of alumina, 3-30% by weight of zinc oxide, 4-30% by weight of P2O5 and 3-25% by weight of fluoride, and an acidic copolymer reactive with the particulate glass under aqueous conditions. An aqueous polymer solution comprising 10 to 65% by weight of the acidic copolymer of the hardening composition with a mean molecular weight of from 50,000 to 200,000, obtainable by a process comprising the copolymerization of a mixture containing acrylic acid and an acrylic acid ester (I) and / or a compound of the formula (II) and, optionally, a compound of the formula (III): Fo...


Title: DENTAL RETRACTION COMPOSITION, PRODUCTION THEREOF AND USE OF A POWDER JET DEVICE FOR DENTAL RETRACTION

Publication No: WO2009/076332
Pub. Date - Int. Class - Applicant: - 18.06.2009 - A61K 6/00 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a dental composition comprising a hardenable powder to be used in a process for retraction of dental tissue. The invention also relates to a kit of parts comprising the dental composition comprising a hardenable powder, a hardening agent, optionally a handpiece of a powder jet device, optionally a powder jet device, and optionally retraction caps. In a further aspect, the invention relates to a method for retracting dental tissue comprising the steps of applying a dental composition comprising a hardenable powder with a powder jet device into the sulcus between soft and hard dental tissue, applying a composition comprising a hardening agent either before or after the previous step, leaving the dental composition in ...


Title: NOVEL USE

Publication No: WO2009/074589
Pub. Date - Int. Class - Applicant: - 18.06.2009 - A61Q 11/00 - GLAXO GROUP LIMITED
The use of an oral care composition comprising nanoparticulate calcium fluoride is described for combating dental erosion and tooth wear.


Title: COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING

Publication No: WO2009/073808
Pub. Date - Int. Class - Applicant: - 11.06.2009 - C07K 19/00 - UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the repair of cell membranes. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with cell membrane damage.


Title: COMPOSITIONS CONTAINING BENEFIT AGENTS COMPOSITES PRE-EMULSIFIED USING COLLOIDAL CATIONIC PARTICLES

Publication No: WO2009/073729
Pub. Date - Int. Class - Applicant: - 11.06.2009 - C11D 3/12 - AMCOL INTERNATIONAL CORPORATION
A cleansing or a surface-conditioning composition comprising a mixture of (i) and (ii) in water: i) a surfactant selected from the group consisting of anionic, non- ionic, zwitterionic, cationic, and mixtures thereof; and ii) a hydrophobic benefit agent in a particulate form having a mean particle size in the range of i - 1,000 micron, and a specific gravity of > l, not encapsulated within a film or a capsule-like enclosure, the particulate hydrophobic benefit agent comprising: a) a physically- modified form of the hydrophobic benefit agent; and b) a deposition-aid material bonded to the surface of the physically-modified benefit agent, wherein the bonding between the benefit agent and the deposition-aid material is achieved prior to a...


Title: METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES

Publication No: WO2009/073193
Pub. Date - Int. Class - Applicant: - 11.06.2009 - A61K 9/127 - THE JOHNS HOPKINS UNIVERSITY
The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.


Title: ANTIMICROBIAL COMPOSITIONS COMPRISING FATTY ACIDS AND MILK PROTEINS

Publication No: WO2009/072097
Pub. Date - Int. Class - Applicant: - 11.06.2009 - A61K 31/19 - WESTGATE BIOLOGICAL LIMITED
An antimicrobial composition comprising a blend of two or more natural free fatty acids derivable from milk serum lipid, the free fatty acids being selected from: butyric (C4); caproic (C6); caprylic (C8); capric (Cl O); lauric (C12); myristic (C14); palmitic (C 16): palmitoleic 5 (C16:l ); stearic (Cl 8); oleic (C18:l); linoleic (Cl 8:2); linolenic (C18:3); and esterified derivatives thereof, and a milk, protein as an emulsifying agent for the free fatty acids wherein at least 35% of the total lipid content comprises free fatty acids selected from one or more of: butyric, caproic, caprylic, capric and lauric.


Title: METHODS AND APPARATUS FOR APPLYING DENTAL SEALANT TO AN ORTHODONTIC PATIENT’S TEETH

Publication No: WO2009/070480
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A61C 7/14 - 3M INNOVATIVE PROPERTIES COMPANY
A set of orthodontic appliances is releasably connected to wall portions of a bonding tray that is used in an indirect bonding procedure. A quantity of dental sealant is applied to wall portions of the tray, and is subsequently transferred to enamel surfaces of the patient s teeth when the bonding tray is placed in position over one of the patient s dental arches. The dental sealant tends to reduce the formation of plaque in regions of the patient s tooth surfaces adjacent the orthodontic appliances.


Title: USE OF ALGINATE OLIGOMERS IN COMBATING BIOFILMS

Publication No: WO2009/068841
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A01N 43/46 - ALGIPHARMA IPR AS
The invention provides a method for combating biofilm, said method comprising contacting a biofilm with an alginate oligomer. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use in the treatment or prevention of a biofilm infection in a subject. In another aspect the method can be used to combat biofilms, on abiotic surfaces, e.g. for disinfection and cleaning purposes.


Title: TAPENTADOL COMPOSITIONS

Publication No: WO2009/067703
Pub. Date - Int. Class - Applicant: - 28.05.2009 - A61K 31/135 - NECTID, INC.
The present invention provides a method of treating pain and pain related conditions by administering to a patient in need thereof, a therapeutically effective amount of a slow release Tapentadol Hydrochloride and therapeutically effective amount of a second analgesic, wherein the second analgesic is tramadol, gamma- aminobutyric acid (GABA) analogue or an NSAID. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a slow release Tapentadol Hydrochloride and a therapeutically effective amount of a second analgesic, wherein the second analgesic is tramadol, gamma-aminobutyric acid (GABA) analogue or an NSAID.


Title: TOPICAL COMPOSITION FOR TREATING PAIN

Publication No: WO2009/067535
Pub. Date - Int. Class - Applicant: - 28.05.2009 - A61K 31/77 - XVASIVE, INC.
Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands...


Title: STERILIZING COMPOSITIONS COMPRISING PHOSPHORS FOR CONVERTING ELECTROMAGNETIC RADIATION TO UVC RADIATION AND METHODS FOR USING THE SAME

Publication No: WO2009/064845
Pub. Date - Int. Class - Applicant: - 22.05.2009 - C09K 11/66 - BERNSTEIN, Eric, F.
There is disclosed a composition for converting electromagnetic energy to ultraviolet C (UVC) radiation or radiation of a shorter wavelength, the composition comprising at least one phosphor capable of converting an initial electromagnetic energy (A) to an electromagnetic energy (B) comprising UVC radiation or radiation of a shorter wavelength, and an organic or inorganic media containing said phosphor. There is also a method of sterilizing an article by exposing it to UVC radiation or radiation of a shorter wavelength for a time sufficient to deactivate or kill at least one microorganism and/or for a time sufficient to inhibit abnormal cell growth within the body, when said composition is in an implantable medical device. A method of coati...


Title: COMPOSITION

Publication No: WO2009/063250
Pub. Date - Int. Class - Applicant: - 22.05.2009 - A61K 8/44 - INNOSPEC LIMITED
An aqueous shear-thinning personal care composition comprises : (a) at least 3 wt% of a sulfonate compound of general formula (I): where R1 represents a C8-22 alkyl group alkyl group; R2 represents a C1-4 alkyl group; each of R3, R4 and R5 independently represents a hydrogen atom or a C1-4 alkyl group; and M+ represents a sodium or potassium cation; (b) at least 3 wt% of an amphoteric or zwitterionic surfactant; (c) at least 10 wt% of water; and (d) at least 0.5 wt% of an additional c...


Title: ORAL HYGIENE CASE WITH DENTAL FLOSS LID COMPARTMENT

Publication No: WO2009/062278
Pub. Date - Int. Class - Applicant: - 22.05.2009 - A46B 11/00 - SOUZA, Nilson Altair de
Oral hygiene case with dental floss lid compartment, refers to the present invention an improved case with lid compartment to hold dental floss or ribbon, and for keeping a toothbrush or toothpaste in its body that presents constructivity and advanced design with access to the case's body (1) interior concomitant with opening the dental floss lid compartment (2) for use, presents also length and intern volume flexibility, accessories to hang, allowing change of its shape, saving the use of pollutant materials, showing excellent cost-benefit ratio.


Title: DENTAL CLEANSER AND STAIN PREVENTION APPARATUS

Publication No: WO2009/061526
Pub. Date - Int. Class - Applicant: - 14.05.2009 - A46B 9/04 - ROSS, Karen, L.
Several embodiments of a dental cleanser and stain prevention apparatus for portable use are described. In each embodiment an apparatus for use in on-the-go dental cleansing is described. In one series of embodiments, disposable dental cleaning devices are described. In another series of embodiments, reusable and refillable dental cleaning devices are described. Packaging of various types is also disclosed for use in housing the dental cleanser and stain prevention apparatus.


Title: METHOD AND COMPONENTS FOR PRODUCING EDENTULOUS DENTURES

Publication No: WO2009/061337
Pub. Date - Int. Class - Applicant: - 14.05.2009 - A61C 9/00 - GLOBAL DENTAL IMPRESSION TRAYS, INC.
A method and component devices for producing edentulous dentures. The method includes obtaining a cast impression of a jaw, any teeth and gingiva area with a first set of dental trays including selecting a properly sized upper dental tray (10) and a properly sized lower dental tray (50), applying impression material in each said tray and placing each said dental impression tray with said impression material in said oral cavity in order to deform uncured impression material. A second set of dental trays is utilized including a lower dental tray (100) having a contact plate (1 10) with an upwardly extending shoulder (1 12) surrounding a tapered opening, a ball nut (114) retained in the tapered opening, and a post (116) adjustably secured to t...


Title: COMPOSITION FOR PREVENTION AND TREATMENT OF PAIN CONTAINING CURCUMIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT

Publication No: WO2009/061152
Pub. Date - Int. Class - Applicant: - 14.05.2009 - A61K 31/12 - SNU R &DB FOUNDATION
The present invention relates to a composition for prevention and treatment of pain containing curcurnin or pharmaceutically acceptable salts thereof as an active ingredient. The composition for prevention and treatment of pain according to the present invention may significantly inhibit the activation of TRPVl which causes all pain including dentalgia and inflammation induced by various stimulants such as temperature, capsaicin, and acids, effectively inhibit pain caused thereby, and be produced from natural products. Thus, the composition is biologically stable and may be used in the products for treatment and alleviation of pain, including analgesics, functional toothpastes for prevention and improvement of pain, functional foods, and fo...


Title: ORAL STANNOUS COMPOSITIONS

Publication No: WO2009/060385
Pub. Date - Int. Class - Applicant: - 14.05.2009 - A61K 8/19 - THE PROCTER &GAMBLE COMPANY
The present invention relates to an aqueous oral composition comprising: a) from 0.2% to 3% divalent metal ions comprising: i. from 0.1% to 1.5% of zinc ions; ii. from 0.1% to 2% of tin (II) ions; and b) a source of fluoride ions; c) a silica dental abrasive; d) one or more chelants having a MW of less than 1000 and capable of forming water-soluble complexes with the zinc ions, wherein the chelants comprise less than 0.2% linear polyphosphates having a chain length of four or more; e) an orally acceptable carrier comprising at least 20% total water; wherein the pH of the composition is from 5 to 6.5, the molar ratio of the chelants to the divalent metal ions is at least 0.70: 1 and at least 80% by weight of the total zinc ions are solubilis...


Title: A METHOD FOR TREATING AILMENTS OF THE ORAL CAVITY WITH A KRILL ENZYME COMPOSITION

Publication No: WO2009/060013
Pub. Date - Int. Class - Applicant: - 14.05.2009 - A61K 38/48 - HELLGREN, Kristian
The invention relates to a method for treating, controlling and/or preventing diseases of the oral cavity, particularly diseases and disorders induced accumulation of plaque, by administering a chewing gum composition comprising at least one krill enzyme. Specifically, the invention is directed to a method for preventing, treating and controlling the development of gingivitis, gum disease and symptoms thereof using a composition having a krill enzyme concentration of about 0.005 U/g to about 0.05 U/g of the chewing gum composition.


Title: MIXING DEVICE INCLUDING A PLUNGING MIXING MEMBER FOR USE WITH A SYRINGE

Publication No: WO2009/059040
Pub. Date - Int. Class - Applicant: - 07.05.2009 - A61M 5/19 - ULTRADENT PRODUCTS, INC.
Mixing devices (100) used with a syringe or syringe system (150) and related systems for homogenously mixing two part compositions, as well as single part compositions which include components that may tend to separate over time (e.g., a fluoride varnish composition). The devices (100) and systems (150) include a hollow elongate handle (104) having a proximal end (106), a distal delivery end (108), and a delivery passageway therethrough. A mixing member (110) is disposed at or near the proximal end (106) of the hollow elongate handle (104), which mixing member and a portion of the handle are axially slidable within a syringe barrel (120) during use. The user may push and pull the distal end (108) of the handle (104), causing corresponding a...


Title: DENTAL COMPOSITIONS AND INITIATOR SYSTEMS WITH COLOR-STABLE AMINE ELECTRON DONORS

Publication No: WO2009/058843
Pub. Date - Int. Class - Applicant: - 07.05.2009 - A61K 6/08 - 3M INNOVATIVE PROPERTIES COMPANY
The invention features a hardenable dental composition, e.g., polymerizable dental restoratives, adhesives, etc., that contain a color-stable amine electron donor in an initiation system for initiating polymerization of the composition.


Title: ADJUSTABLE DENTAL X-RAY IMAGE MEDIA HOLDER

Publication No: WO2009/058342
Pub. Date - Int. Class - Applicant: - 07.05.2009 - G03B 42/04 - DENTSPLY INTERNATIONAL INC.
A dental x-ray image media holder (10) includes an image media backing plate (11) adjustably affixed to a bite block (12). The backing plate (11) has at least one channel (31-33) for receiving a post (21) affixed to the bite block (12), such that the bite block (12) can be selectively moved within the channel (31-33) to orient the bite block (12) in a predetermined position relative to the backing plate (11).


Title: DENTAL COMPOSITION FOR DETECTING BACTERIA, KIT OF PARTS AND USE THEREOF

Publication No: WO2009/055530
Pub. Date - Int. Class - Applicant: - 30.04.2009 - C12Q 1/00 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a dental composition for detecting bacteria comprising a solvent, at least one electron acceptor component and at least one electron donor component, the composition being substantially free of components which enable or facilitate the electron transmission between the electron acceptor component and the electron donor component. The invention also relates to a kit of parts and the use of the dental composition for producing a means for the inter-oral detection of bacteria.


Title: TIME-CONTROLLED INTRAORAL FILM FORMER SYSTEM FOR INTRAORAL USE

Publication No: WO2009/052493
Pub. Date - Int. Class - Applicant: - 23.04.2009 - A61K 31/74 - BISCO, INC.
A water soluble polymer or biodegradable polymer operable to act as a release or separator between a prepared and sealed dentin surface and a temporary restoration.


Title: FUNCTIONALIZED SUBSTRATES WITH THIN METAL OXIDE ADHESION LAYER

Publication No: WO2009/052352
Pub. Date - Int. Class - Applicant: - 23.04.2009 - B05D 3/10 - PRINCETON UNIVERSITY
Polymer substrates including adhesion layers for activating the surface of the substrate are provided, thereby allowing the substrate to react with organic, inorganic, metallic and/or organometallic materials. The surface of the polymer substrate is coated with a metal oxide layer that is subjected to conditions adequate to form an oxide adhesion layer. Combining deposition techniques for formation of functionalized polymer surfaces with photolithographic techniques enables spatial control of RGD presentation at the polymer surfaces are achieved with sub-cellular resolution. Surface patterning enables control of cell adhesion location at the surface of the polymer and influences cell shape. Metallization of polymers as described herein prov...


Title: ORAL HYGIENE PRODUCTS CONTAINING ASCORBIC ACID AND METHOD OF USING THE SAME

Publication No: WO2009/052180
Pub. Date - Int. Class - Applicant: - 23.04.2009 - A61K 8/67 - DENTECH, INC.
The present invention is directed to dental compositions, including dentifrices, containing ascorbic acid for removing and inhibiting dental biofilms which form plaque and tartar, and also for treating and preventing gingivitis and periodontitis. The ascorbic acid composition can contain many additional ingredients, including an enamel-strengthening component, and be used in many different forms, including breath spray, chewing gum, dental floss, dental powder, gargle, lozenge, mouth spray, mouth wash, tooth gel, tooth liquid, tooth paste and tooth strips. Also described is a method of using a dental composition containing ascorbic acid in order to treat plaque and tartar as well as gum disorders.


Title: ALPHA-AMYLASE INHIBITORS: THE MONTBRETINS AND USES THEREOF

Publication No: WO2009/049428
Pub. Date - Int. Class - Applicant: - 23.04.2009 - C07H 15/26 - THE UNIVERSITY OF BRITISH COLUMBIA
Particular naturally occurring glycosylated acyl-flavonols, e.g. montbretm A (of the formula below wherein R1, R2, R3, R5, R5', and R7 is OH each, X is ?-D-glucopyranosyl), are now shown to be effective mammalian ?-amylase inhibitors Such compounds can be obtained from plants of the genus Crocosmia The compounds and their analogs of the formula below are useful in controlling starch digestion such as for management of glycermia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation R1
Title: USE OF NITRIC OXIDE TO ENHANCE THE EFFICACY OF SILVER AND OTHER TOPICAL WOUND CARE AGENTS

Publication No: WO2009/049208
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61K 31/33 - THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpect...


Title: AN AIR INJECTION TYPE PORTABLE DENTAL FLOSSES

Publication No: WO2009/048281
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61C 15/00 - KANG, So-Dae
An air injection portable inter-dental toothbrush can be devised consisting of: driving section (10), including air injection pan (14), filter (15) for removing foreign aerial substance from outside, pan motor (16) for bringing in air and supplying it to air injection pan (14), battery (18) as a power for driving the pan and a battery still attached bedding(19); cleaning section (20), including cleansing fluid inlets and hose (24) which is composed of a container (21) for keeping cleansing fluid, where the cleansing fluid container (21) is connected to the hose while the other end of the latter being attached to the center of the gravity so that the fluid inlets and hose can infuse cleansing fluid no matter how the container's position chan...


Title: HEAT TRANSFER COMPOSITIONS

Publication No: WO2009/047542
Pub. Date - Int. Class - Applicant: - 16.04.2009 - C09K 5/04 - INEOS FLUOR HOLDINGS LIMITED
A composition comprising R-1243zf, (3,3,3 trifluoropropene), R-134a (1,1,1,2 tetrafluoroethane), and R-32 (difluoromethane).


Title: HEAT TRANSFER COMPOSITIONS

Publication No: WO2009/047535
Pub. Date - Int. Class - Applicant: - 16.04.2009 - C09K 5/04 - INEOS FLUOR HOLDINGS LIMITED
A composition comprising: (i) a first compound comprising R-1243zf, (3,3,3 trifluoropropene) or a difluoropropene (R-1252) selected from R-1252zf, R-1252yf, R- 1252ye R-1252ze and R-1252zc, and mixtures thereof; (ii) a second compound selected from R-1225ye(E), R-1225 ye(Z) (both 1,2,3,3,3 pentafluoropropene), R-152a (1,1, difluoroethane), R-134a (1,1,1,2 tetrafluoroethane), R-227ea (1,1,1,2,3,3,3 heptafluoropropane) and R-125 (pentafluoroethane), and mixtures thereof; and (iii) a third compound selected from R-1270 (propylene), R-32 (difluoromethane), R-161 (fluoroethane) and R-1234yf (2,3,3,3 tetrafluoropropene), carbon dioxide (CO2) and mixtures thereof.


Title: SELF-DISPENSING DENTAL FLOSS APPLICATOR

Publication No: WO2009/047227
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61C 15/04 - TIPHONNET, Joel
A self-dispensing dental floss applicator that has a U-shaped elongated housing (1) with two hollow prongs (4a, 4b) set perpendicularly to the body at one end and a larger opposite end to contain the locking mechanism, the dispensing mechanism, the spool (3) of fresh floss and the spool (18 or 21) of used floss. The locking mechanism composed of a casing (5), an axle (9), two lower grip pads (17a, 17b), two upper grip pads (7a, 7b), two strip springs (8a and 8b) and a lever (6) with two eccentric friction parts is used to hold the floss in position thus creating the right tension on the floss. A tension pin (19) containing a screw (20) is provided to increase floss tension if/when needed by the user. Rotating the lever (6) up unlocks the fl...


Title: DENTAL COMPOSITION CONTAINING GLASS BEADS, PROCESS FOR PRODUCTION AND USE THEREFOF

Publication No: WO2009/046056
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61K 6/027 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a dental impression composition comprising a hardenable matrix and glass beads having a particle size (d50/?m) equal or below about 60 ?m. The invention also relates to a method of producing this composition and its use.


Title: FOAMABLE FLUORIDE ORAL CARE COMPOSITION

Publication No: WO2009/045949
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61K 8/44 - COLGATE-PALMOLIVE COMPANY
A dental fluoride foam composition comprising an aqueous solution of a water soluble fluoride ion releasable salt; a surfactant selected from the group consisting of nonionic surfactants, zwitterionic surfactants, betaine surfactants and mixtures thereof; and an orally compatible acidifying agent in an amount sufficient to adjust the pH of the composition to about 3 to about 5. The composition is stable at low temperatures and is a clear solution substantially free of precipitates when held at 4.4°C for 12 hours. When dispensed from a container into the trough of a dental tray, the composition forms a low density, rapidly collapsible foam which substantially liquefies in about 1 minute after being dispensed from the foam generating contain...


Title: ACTIVATING BRUSH TIP APPLICATORS FOR DENTAL BLEACHING COMPOSITIONS

Publication No: WO2009/045856
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61C 13/08 - ULTRADENT PRODUCTS, INC.
A brush tipped applicator (10) includes an applicator tip (26) having a body defining an external surface and an internal conduit (28). The applicator tip body (26) can have a proximal end defining a proximal opening of the internal conduit (28) and a distal end. The proximal end of the applicator tip body (26) can have a first fastener (24) that is configured for being coupled to a fastener (i.e., second fastener) of a member (16) containing the dental bleaching composition such that the internal conduit (28) of the applicator tip body (26) is capable of being fluidly coupled with the dental bleaching composition. Additionally, the brush tip (30) includes at least one filament (32) disposed on the external surface of the applicator tip bod...


Title: METHOD OF MAKING A SCAFFOLD FOR TISSUE AND BONE APPLICATIONS

Publication No: WO2009/045176
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61L 27/56 - BIO-SCAFFOLD INTERNATIONAL PTE LTD
A method of making a scaffold for tissue regeneration and/or bone growth includes providing a polymer, providing a scaffold structure using the polymer, wherein the scaffold structure includes the polymer and pores, exposing the scaffold structure to an organic solvent, and removing the organic solvent from the scaffold structure to provide the scaffold, wherein exposing the scaffold structure to the organic solvent and removing the organic solvent from the scaffold structure increases a strength of the scaffold structure by increasing a chemical bond strength of the polymer. Advantageously, the scaffold has high strength, high porosity and a well-controlled pore structure.


Title: METHACRYLATE BASED MONOMERS CONTAINING A URETHANE LINKAGE, PROCESS FOR PRODUCTION AND USE THEREOF

Publication No: WO2009/042574
Pub. Date - Int. Class - Applicant: - 02.04.2009 - C07C 271/16 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a dental composition comprising a monomer or mixture of monomers represented by the following structure (1) with 1,2Rindependently selected from H, alkyl (e.g. CH3 C2H5), and Phenyl, 3,4R independently selected from H, alkyl (e.g. CH3), and halogen (Cl, Br, F), 5R independently selected from H, alkyl (e.g. CH3), m, n = 1, 2 and x + y = 2 to 10, with the proviso that if m = n ...


Title: POLYMER IMPRESSION MATERIALS

Publication No: WO2009/039156
Pub. Date - Int. Class - Applicant: - 26.03.2009 - C08F 2/46 - THE REGENTS OF THE UNIVERSITY OF COLORADO
This invention relates to methods and compositions for single component photoinitiated dental impression materials. The impression material is workable in its pre-cured state, cures rapidly upon exposure to light, and exhibits desirable processing conditions such as short setting time, long working time, no void formation, good wettability, mechanical properties, and detail reproduction.


Title: CURABLE DENTAL RETRACTION COMPOSITION, METHOD OF PRODUCTION AND USE THEREOF

Publication No: WO2009/035961
Pub. Date - Int. Class - Applicant: - 19.03.2009 - A61K 6/097 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a curable dental retraction composition comprising alginate and a solvent, with the proviso that essentially no crosslinker in an amount effective to start setting of the curable dental retraction composition is present. The invention also relates to a container containing said composition and to a kit comprising two parts, wherein the first part comprises the curable dental retraction composition of the present invention and the second part comprises a crosslinker being able to start setting of the dental retraction composition.


Title: HYBRID INDUCIBLE RELEASE VEHICLE

Publication No: WO2009/035331
Pub. Date - Int. Class - Applicant: - 19.03.2009 - A23L 1/00 - NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
The invention is directed to a hybrid inducible release vehicle, to a method for preparing such a vehicle, and to the use thereof. The hybrid inducible release vehicle of the invention comprises a gel, which gel comprises a cross-linked carbohydrate and/or protein polymer and an inorganic carrier, and at least one active ingredient bound to said inorganic carrier, wherein the release of the active ingredient is triggered by contact of the vehicle with an external stimulus.


Title: METHOD FOR OBTAINING A SURFACE OF A TITANIUM-BASED METAL IMPLANT INTENDED TO BE INSERTED INTO BONE TISSUE

Publication No: WO2009/034197
Pub. Date - Int. Class - Applicant: - 19.03.2009 - A61C 8/00 - GARCIA SABAN, Francisco, J.
The invention relates to a method for obtaining a surface of a titanium-based metal implant intended to be inserted into bone tissue, comprising the following steps in which: (a) aluminium oxide particles are pressure-sprayed against the external area of the implant; (b) the shotblasted external area of the implant is chemically treated with an acid composition containing sulphuric acid and hydrofluoric acid; and (c) following said chemical treatment, the shotblasted external area of the implant is thermally treated using heat at a temperature of 200-450 °C for 15-120 min. The invention also relates to a metal implant having said surface. The resulting surface has: good micrometer-scale roughness with a suitable morphology, a composition t...


Title: MONOLITHIC DENTAL IMPLANT WITH NATURAL LOAD RESPONSE

Publication No: WO2009/032790
Pub. Date - Int. Class - Applicant: - 12.03.2009 - A61C 8/00 - PLASTIC DENTAL CORPORATION
A monolithic dental implant is provided made from a material or materials having a elasticity moduli less than approximately 4 Msi. The materials can be either a polymer or a composite material having a polymer matrix and a fiber- or particulate-reinforced second phase. When subject to occlusive forces, the monolithic dental implant provides improved lateral transmission of the forces, resulting in a reduction in bone resorption. Additionally, because the dental implant is monolithic, it is not subject to the problems associated with bacteria collection and abrasive wear common to multi-component dental implants.


Title: DENTIFRICE COMPOSITIONS FOR TREATING XEROSTOMIA

Publication No: WO2009/032406
Pub. Date - Int. Class - Applicant: - 12.03.2009 - A61K 31/4425 - COLGATE-PALMOLIVE COMPANY
This invention encompasses an oral composition for treating or preventing dry mouth with following benefits: antibacterial/ anti-fungal efficacy, low irritancy, and moisture retention. The compositions can be a toothpaste, a mouth rinse or a spray and include one or more non-ionic surfactants, as foaming agents, one or more broad spectrum anti-microbial ingredient, such as chlorhexidine and cetylpyridinium chloride, and one or more oral surface adhesive polysaccharides that can encage cationic actives to help the deposition and retention of the agents onto oral surfaces and thus provide antimicrobial efficacy.


Title: CONTROLLED SURFACE GELLING OF MUCOADHESIVE POLYMERS ON ORAL MUCOSA

Publication No: WO2009/032404
Pub. Date - Int. Class - Applicant: - 12.03.2009 - A61Q 11/00 - COLGATE-PALMOLIVE COMPANY
The present invention relates to an oral composition and method for alleviati the symptoms associated with xerostomia using encapsulated cation-releasing compounds formulated either intimately together or in separate compartments in a composition containing cation-sensitive mucoadhesive polymers.


Title: DENTAL TREATMENT TRAYS COMPRISING SILICONE OR OTHER ELASTOMERIC MATERIAL

Publication No: WO2009/029886
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61C 7/08 - ULTRADENT PRODUCTS, INC.
Non-customized dental treatment trays (100) used to provide a desired treatment are formed from elastomeric silicone or silicone-like material. They may be injection molded from a two-part liquid silicone composition or a silicone-like TPE material (e.g., preferably SEBS and/or VERSAflex thermoplastic elastomer). The dental treatment trays (100) possess high adaptability, flexibility, softness, and elastic elongation while also exhibiting resiliency in order to readily conform to the ridges, depressions and contours of a person's teeth during use. The trays (100) possess a greater ability to adhere to a person's teeth compared to non-elastomeric thermoplastic materials. Due to their high adaptability and conformability, the non- customized ...


Title: CHEMICALLY ACTIVATED DENTAL BLEACHING TRAYS

Publication No: WO2009/029781
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61C 5/00 - ULTRADENT PRODUCTS, INC.
Dental treatment trays (100) and strips (400) used to deliver a dental bleaching composition to a person's teeth are formed from a moisture resistant barrier material (102) and include a bleaching agent destabilizer disposed on an inner treatment surface (103) of the barrier layer (102) that is positioned against the person's teeth during use. The bleaching agent destabilizer may be compounded with the moisture resistant material or otherwise disposed relative to the barrier layer (102) so that at least some destabilizer is positioned on the inner treatment surface (103) of the tray (100) or strip (400) so as to contact the dental bleaching composition during use.


Title: ANTI-MICROBIAL FLUORIDE RINSES, AND METHODS OF USE THEREOF

Publication No: WO2009/029434
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 8/69 - THE NATURAL DENTIST
One aspect of the invention relates to oral hygiene compositions that comprise, consist essentially of, or consist of water; vegetable glycerin; aloe vera gel; xylitol; Echinacea; monobasic sodium phosphate; Goldenseal; Calendula; at least one natural flavor; grapefruit seed extract; at least one natural colorant; sodium fluoride; olivamidopropyl betaine and citric acid. Another aspect of the invention relates to treating and/or preventing one or more of dental caries, oral microbial infections, oral inflammation, and dentine hypersensitivity, comprising applying to the oral cavity of a mammal a composition of the invention.


Title: A BONE AND/OR DENTAL CEMENT COMPOSITION AND USES THEREOF

Publication No: WO2009/029049
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 6/08 - NATIONAL UNIVERSITY OF SINGAPORE
The present invention provides a composition comprising: at least one viscosity- enhancing agent; and at least one macromonomer. In particular, the composition may be a bone cement composition and/or a dental cement composition. The composition may be used in medicine. The composition may be used in orthopedic and/or periodontal applications. The present invention also provides uses of the composition.


Title: MICRO-PERFORATED TRAYS

Publication No: WO2009/027845
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61C 19/06 - LÜDI, ETCHEVARREN, Viviana, Clelia
The invention relates to trays used to perform oral treatments with high concentrations of oxygen/ozone. Ozone therapy is a technique widely used in various specialties of medicine, including odontology, and work carried out in the specialty has led to the design of devices for use in the treatment of periodontal disease, bleaching and dental caries. In all medical specialties operating concentrations are high and the ozone is always generated from medical oxygen. However, in odontology treatment concentrations are very low and it is sometimes possible to work with ambient oxygen in the mouth. The invention relates to trays having the following essential characteristics: an inner chamber through which the gas flows, micropores (microperfora...


Title: PHARMACEUTICAL COMPOSITION FOR SELECTIVE STIMULATION OF WOUND HEALING PROCESSES, DERMAL-EPIDERMAL NORMAL TISSULAR TROPHISM PROCESSES, ITS PREPARATION AND APPLICATION.

Publication No: WO2009/027823
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 31/7036 - RAMIREZ D'ONOFRIO, Alvaro D.
The present invention discloses pharmaceutical compositions for selective stimulation of wound healing processes, dermal-epidermal normal tissular trophism processes for internal and external use, containing gentamicin sulphate, metronidazole, papain, metronidazole Balsam of Peru, and an excipient or vehicle pharmaceutically acceptable.


Title: DENTAL ADHESIVE COMPOSITION

Publication No: WO2009/027005
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 6/00 - DENTSPLY DETREY GMBH
A polymerizable dental adhesive composition having bactericidal activity and high storage stability prior to curing. Said composition comprising hydrolysis-stable polymerizable monomers, a water soluble organic solvent, an initiator and a stabilizer.


Title: MEDICAL DEVICE WITH BIOFUNCTIONALIZED POLYMER COATING

Publication No: WO2009/026380
Pub. Date - Int. Class - Applicant: - 26.02.2009 - B05D 3/00 - THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
The present invention is thus directed to coating compositions and methods of their use, and to the objects coated therewith, for their use as implants and medical devices In particular, the medical devices and implants of the present invention comprise biomate?als which are coated with functionalized polymers having biomolecules conjugated thereto, or with the functionalized polymers to which such biomolecules can be conjugated to form the biofunctionalized polymer The biomolecules attached to the functionalized polymers contemplated herein may be defined as natural or synthetic chemical compounds which possess an ability to covalently bond to the functional group on the functionalized polymer or a spacer thereon, preferably via a sulfhyd...


Title: METHOD FOR MANUFACTURING THE ONE BODY ABUTMENT OF IMPLANT

Publication No: WO2009/025442
Pub. Date - Int. Class - Applicant: - 26.02.2009 - A61C 8/00 - KIM, Jung Han
A method of manufacturing an abutment of an artificial tooth, which includes an implant fixture installed in a jaw bone and a crown defining a contour thereof. The abutment is fixed to the implant fixture to connect the implant fixture to the crown. A three-dimensional image of an oral cavity of a patient is generated on a computer by 3D scanning of a dental plate of plaster. A virtual tooth is designed using the image of the oral cavity, in consideration of a row of teeth in a region from which a tooth is missing, the height of adjacent teeth and alignment with an upper or lower tooth. The shape of the abutment is designed according to the shape of the designed virtual tooth. Data on the designed abutment is transmitted to a precision mach...


Title: DENTAL RETAINER

Publication No: WO2009/022986
Pub. Date - Int. Class - Applicant: - 19.02.2009 - A61C 7/08 - BIOMERS PRODUCTS LLC
The invention provides a dental retainer, suitable for use in retaining a user's teeth (not shown) in position, said dental retainer comprising a curved labial bow member suitable for abutment against the labial side of a row of teeth of a user, said bow member being composed of a fiber reinforced matrix of a suitable thermoplastic material. The bow member is configured and dimesioned to extend operationally from a first end to a second end along a labial side of a user's teeth from at least a pre-molar to a pre-molar on an opposed side of a user's mouth. The dental retainer further comprises a pair of support members which are connected to the ends of the labial bow member at their anterior ends respectively. Preferably, the support member...


Title: COMPOSITIONS AND METHODS OF USE THEREOF, FOR THE TREATMENT OF ORAL PAIN, COMPRISING CLOVES OR EXTRACT THEREOF IN COMBINATION WITH A STEROID

Publication No: WO2009/020561
Pub. Date - Int. Class - Applicant: - 12.02.2009 - A61K 45/06 - XVASIVE INC.
Provided are compositions for delivery to an individual's mouth to provide immediate as well as long-lasting pain relief, particularly after tooth extraction or other dental procedure, which include clove, a clove extract or eugenol, and optionally a steroid and other additives including an antibiotic. Kits and systems for delivery of the composition to provide sustained pain relief are also provided.


Title: COATING

Publication No: WO2009/019477
Pub. Date - Int. Class - Applicant: - 12.02.2009 - A61L 31/10 - SMITH &NEPHEW PLC
The invention relates to a coating composition for an implantable medical device, a method of coating a medical device and a device coated with the composition.


Title: USE OF CRANBERRY EXTRACT ENRICHED IN TOTAL PHENOLS AND FREE ESSENTIALLY FREE, OR SUBSTANTIALLY FREE OF SUGARS, ACIDS, SULFUR AND OTHER CONTAMINANTS, FOR PERIODONTAL TREATMENT

Publication No: WO2009/018470
Pub. Date - Int. Class - Applicant: - 05.02.2009 - A61K 36/45 - PHENOLICS, LLC
Cranberry and other plant extracts enriched in total phenols and free or substantially free of sugars, acids, sulfur and other contaminants are used for periodontal treatments. The periodontal treatments of the present invention include swish and swallow techniques, in which the extracts enriched in total phenols but free or substantially free of sugars, acids, sulfur and other contaminants, are solubilized in water or other solvent, placed in the mouth, swished around the teeth and then swallowed. Other application techniques include gel applications, gum formulations and toothpaste formulations.


Title: PHOTODISINFECTION OF ORAL CAVITY

Publication No: WO2009/018205
Pub. Date - Int. Class - Applicant: - 05.02.2009 - A61C 19/06 - ONDINE INTERNATIONAL LTD.
A composition for photodisinfection of the oral cavity comprising toothpaste and a photosensitizing composition encapsulated within microspheres, wherein the microspheres release the photosensitizing composition into the oral cavity upon contact with liquid and/or force and the photosensitizing composition includes a photosensitizer that upon irradiation of at least one predetermined wavelength will reduce and/or eliminate microbes in the oral cavity. The present invention also includes a method of applying the composition into the oral cavity and applying irradiation to the oral cavity at a wavelength or wavelengths absorbed by the photosensitizing composition so as to reduce or eliminate microbes in the oral cavity.


Title: THERAPEUTIC DENTAL COMPOSITION AND RELATED METHODS

Publication No: WO2009/014907
Pub. Date - Int. Class - Applicant: - 29.01.2009 - A61K 6/083 - 3M INNOVATIVE PROPERTIES COMPANY
Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.


Title: OSTEOPONTIN NANOPARTICLES SYSTEM FOR DRUG DELIVERY

Publication No: WO2009/010071
Pub. Date - Int. Class - Applicant: - 22.01.2009 - A61K 9/51 - AARHUS UNIVERSITET
The present invention relates to nanoparticles comprising osteopontin and a polymer carrier, preferably a cationic carrier. Preferably, the cationic carrier is chitosan. Osteopontin and/or the cationic carrier may have bioactivity and/or the nanoparticle may comprise an additional component with bioactivity. Such additional bioactive component may e.g. be a siRNA. The nanoparticles of the invention may be used for treatment of bone diseases or inflammatory diseases.


Title: PATTERNING STRUCTURES USING DEFORMABLE SUBSTRATES

Publication No: WO2009/009208
Pub. Date - Int. Class - Applicant: - 15.01.2009 - B05D 5/00 - THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Aspects of the present invention describe soft imprint lithography methods capable of preparing structural features on surfaces. Disclosed methods include surmounting a deformable substrate, having an original form, with a composition, wherein the deformable substrate is capable of achieving at least one predetermined deformed state; predictably deforming said deformable substrate from its original form to the at least one predetermined deformed state; and transferring at least a portion of the composition surmounting the deformed substrate to a receiving substrate.


Title: COMPOSITION AND PACKAGING METHOD FOR ANIMAL DENTAL CARE

Publication No: WO2009/009126
Pub. Date - Int. Class - Applicant: - 15.01.2009 - A61Q 11/00 - ALBERT, Karen, L.
A comestible, water-based composition containing natural ingredients provides an effective amount of at least one active ingredient selected to reduce the proliferation of bacteria in the mouth of animals to treat and improve the dental health of animals. The composition can be administered to animals in the form of their daily intake of water and may be especially packaged for ready use and consumption by animals in pre-packaged and portable doses. Compositions containing natural ingredients and formulated as toothpastes for animal dental care are also provided.


Title: COMPRESSED CHEWING GUM COMPRISING AN ENCAPSULATION DELIVERY SYSTEM COMPRISING NATURAL RESIN

Publication No: WO2009/007767
Pub. Date - Int. Class - Applicant: - 15.01.2009 - A23G 4/08 - GUMLINK A/S
The invention relates to a compressible chewing gum composition comprising i) chewing gum granules containing gum base ii) particles of one or more encapsulation delivery systems comprising at least one encapsulation material and at least one active ingredient being encapsulated by the encapsulation material, wherein the encapsulation material comprises at least one natural resin. The compressible chewing gum composition, which has been provided, is suitable for compression into compressed chewing gum tablets. Such compressed chewing gum tablets thus comprise a compression of a quantity of the compressible chewing gum composition and thus comprise chewing gum granules containing gum base and particles of one or more encapsulation delivery s...


Title: NANOSURFACE

Publication No: WO2009/007373
Pub. Date - Int. Class - Applicant: - 15.01.2009 - A61F 2/30 - ASTRA TECH AB
The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.


Title: DENTAL COMPOSITION CONTAINING A POLYFUNCTIONAL (METH)ACRYLATE COMPRISING URETHANE, UREA OR AMIDE GROUPS, METHOD OF PRODUCTION AND USE THEREOF

Publication No: WO2009/006282
Pub. Date - Int. Class - Applicant: - 08.01.2009 - A61K 6/083 - 3M INNOVATIVE PROPERTIES COMPANY
The invention relates to a dental composition comprising a) a hardenable compound (A1), b) a filler (B1), c) an initiator (C1) being able to initiate curing of compound (A1), compound (A1) having the structure A-(-S1-U-S2-MA)n, with A being a connector element, S1 being a spacergroup comprised of units connected with each other and comprising at least 4 units, S2 being a spacergroup comprised of units connected with each other and comprising at least 4 units, U being an urethane, an amide or an urea group connecting spacergroups S1 and S2, MA being an acrylate or methacrylate group and n being 3 to 6. The invention also relates to a process of producing this dental composition and using the dental composition e....


Title: SOFT GEL SYSTEMS IN MODULATING STEM CELL DEVELOPMENT

Publication No: WO2009/005769
Pub. Date - Int. Class - Applicant: - 08.01.2009 - C12N 5/00 - THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
This invention provides gels and matrices having a rigidity in the range of 150-750 Pa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same..

 

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WORLD PATENTS IN ORAL CARE FORMULATIONS PUBLISHED IN 2009
This list includes patent documents published by the World Intellectual Property Organization (WIPO). The list was retrieved by using a refined search strategy in the claims section of all
patent applications. Salient search terms included oral care formulations and compositions for tooth cleaning and whitening; denture and dental prosthesis care; caries, calculus, stains
and plaque prevention, reduction or removal; dental adhesives, dental polymers, cement curing; polymer UV curing, cavity fillers, disinfectants, bleaching; oral hygiene and devices, etc.