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PCT - WORLD PATENTS IN PHARMACEUTICAL EXCIPIENTS PUBLISHED IN 2008




PHARMACEUTICAL COMPOSITION CONTAINING ACETYLCHOLINE ESTERASE INHIBITOR AND METHOD FOR THE PREPARATION THEREOF

(WO2009001146) 31.12.2008 A61K 9/20 GENEPHARM S.A.
A pharmaceutical composition for oral administration comprising donepezil or pharmaceutically acceptable salt thereof, and an effective amount of pH dependent excipient as a taste masking agent, to suppress the release of donepezil in the pH environment of the oral cavity and increase the release of donepezil in acidic environment.


COMPOSITION FOR TRANSMUCOSAL DELIVERY OF POLYPEPTIDES

(WO2008137054) 13.11.2008 A61K 9/46 CEPHALON, INC.
The invention described herein provides an oral solid transmucosal dosage form that enhances transmucosal permeation of biologically active polypeptides across oral mucosal tissue and provides relatively rapid efficacious therapeutic onset thereof. Dosage forms prepared according to the invention can enhance transmucosal absorption of polypeptides in therapeutic serum concentrations to the recipient. The invention provides a solid dosage form for oral transmucosal absorption of a biologically active polypeptide, wherein the dosage form comprises a pharmaceutical composition comprising: a therapeutically active polypeptide; a bile salt; and an effervescent excipient component, which can comprise an effervescent couple and optionally a pH adj...


BILAYER LYOPHILIZED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING AND USING SAME

(WO2008127669) 23.10.2008 A61K 9/24 CEPHALON, INC.
The present invention relates to a bilayer dosage form comprising: - an upper layer (a) comprising a lyophilized dosage form of active pharmaceutical ingredient(s) (API(s)). - a base line layer (b) formulated to adhere to the oral mucosa and intended for delayed, sustained or extended release of API(s) and/or excipient(s).


MELATONIN TABLET AND METHODS OF PREPARATION AND USE

(WO2008127609) 23.10.2008 A61K 31/40 MCCARTY, John, A.
The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.


EXTENDED RELEASE PHARMACEUTICAL FORMULATION OF PROPRANOLOL HYDROCHLORIDE

(WO2008126098) 23.10.2008 A61K 9/48 JUBILANT ORGANOSYS LIMITED
Disclosed herein an extended release pharmaceutical formulation of the propranolol hydrochloride comprising a core and an extended release coating on said core wherein said core comprising said propranolol hydrochloride and one ore more pharmaceutically acceptable excipients and coating comprising extended release polymers in an amount of about 1 to about 5% by weight based on the total weight of the core.


PHARMACEUTICAL COMPOSITIONS

(WO2008125843) 23.10.2008 A61K 9/20 ZYSIS LIMITED
The present invention provides an orally deliverable pharmaceutical composition for the once-daily (OD) administration of trimipramine. The composition comprises a therapeutically effective amount of trimipramine and at least one pharmaceutically acceptable excipient. The compositions of the invention may exhibit one or more of the release profiles defined in this specification.


CONTROLLED RELEASE FORMULATION OF COATED MICROPARTICLES

(WO2008122993) 16.10.2008 A61K 9/16 PANACEA BIOTEC LIMITED
Controlled release compositions comprising microparticles which comprise a core and at least one coat, wherein the core comprises at least one active agent(s), optionally at least one water soluble polymer(s) and optionally one or more pharmaceutically acceptable excipient(s); and at least one coat comprising at least one pH independent polymer(s) along with one or more pharmaceutically acceptable excipient(s) are provided. Preferably the controlled release pharmaceutical compositions comprise microparticles along with at least one in-situ gelling agent(s), at least one cross-linking agent(s) and optionally one or more pharmaceutically acceptable excipient(s), wherein the said compositions are formulated as oral reconstitutable pharmaceutic...


PHARMACEUTICAL FORMULATIONS CONTAINING DAPAGLIFLOZIN PROPYLENE GLYCOL HYDRATE

(WO2008116179) 25.09.2008 A61K 31/70 BRISTOL-MYERS SQUIBB
Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include dapagliflozin propylene glycol hydrate is: Formula (Ia) or Formula (Ib) and a pharmaceutical acceptable carrier therefor, which formulatio


NOVEL ORAL CONTROLLED RELEASE COMPOSITION OF CARVEDILOL

(WO2008114276) 25.09.2008 A61K 9/48 LUPIN LIMITED
A oral controlled release pharmaceutical composition comprising a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, one or more controlled release agent (s) selected from pH independent polymers, water insoluble


PHARMACEUTICAL COMPOSITION CONTAINING A CHOLESTEROL ABSORPTION INHIBITOR

(WO2008101723) 28.08.2008 A61K 31/397 KRKA
The present invention relates to a pharmaceutical composition comprising at least one cholesterol absorption inhibitor in amorphous form and at least one hydrophilic polymer, wherein the amorphous cholesterol absorption inhibitor is finely distributed wit


EXTENDED RELEASE FORMULATIONS OF GLUCAGON AND OTHER PEPTIDES AND PROTEINS

(WO2008098212) 14.08.2008 A61K 38/00 DIOBEX, INC.
A pharmaceutical preparation comprising a suspension of glucagon in the presence of a metallic cation and optionally an excipient provides for a sustained release of glucagon into the circulation of a treated patient following injection of pharmaceutical


ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS

(WO2008070982) 19.06.2008 A61K 39/39 NATIONAL RESEARCH COUNCIL OF CANADA
The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal.


METHOD OF FORMING A TABLET COMPRISING PRE-BLEND OF IBUPROPEN AND SILICON DIOXIDE

(WO2008069938) 12.06.2008 A61K 9/16 SCOLR PHARMA, INC.
A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixin


PREPARATION OF A FREE FLOWING MOLECULAR DISPERSION OF CLOPIDOGREL BASE

(WO2008065674) 05.06.2008 A61K 9/14 GUNTUKA, Venkateswarlu
A solid free flowing molecular dispersion comprising clopidogrel base, at least one pharmaceutically acceptable polymer, at least one pharmaceutically acceptable excipient and optionally surfactant. A process for preparing a solid dispersion comprising di


METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH ANTI-INFLAMMATORIES USING MEDICAL DEVICES

(WO2008063319) 29.05.2008 A61L 31/16 ABBOTT LABORATORIES
A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coa


STABILISED DOSAGE FORMS OF AMLODIPINE BESYLATE

(WO2008062435) 29.05.2008 A61K 47/10 ALKEM LABORATORIES LTD.
The present invention relates to a stable solid dosage form comprising 2-20 % by weight of amlodipine besylate, 10-70 % by weight polyols, at least a known pharmaceutical excipient, and having levels of impurity D (3-ethyl-5-methyl-2[(2-aminoethoxy)-methy


SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS OF ALFUZOSIN AND PROCESS FOR PREPARATION THEREOF

(WO2008050188) 02.05.2008 A61K 9/00 TORRENT PHARMACEUTICALS LIMITED
The present invention relates to sustained release pharmaceutical compositions comprising alfuzosin, a rate-controlling polymer and optionally one or more pharmaceutically acceptable excipients; process for preparing such compositions and method of using


SUSTAINED RELEASE FORMULATIONS COMPRISING VERY LOW MOLECULAR WEIGHT POLYMERS

(WO2008049631) 02.05.2008 A61K 38/09 SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
The present invention relates to a parenteral sustained and controlled release semisolid formulation comprising an oligomer end-capped and an active substance without any supplementary viscosity reducing agent or excipient.


COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES

(WO2008045961) 17.04.2008 A61K 31/37 ABBOTT LABORATORIES
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices co


INJECTABLE DEPOT COMPOSITION AND ITS' PROCESS OF PREPARATION

(WO2008041246) 10.04.2008 A61K 31/18 PANACEA BIOTEC LTD.
Novel injectable compositions are provided comprising an active agent which is tarnsulosin or letrozole or its pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures th


PHARMACEUTICAL COMPOSITIONS OF ARIPIPRAZOLE

(WO2008038003) 03.04.2008 A61K 31/496 ZYSIS LIMITED
The present invention provides an orally deliverable pharmaceutical composition for the controlled release of aripiprazole. The composition comprises a therapeutically effective amount of aripiprazole and at least one pharmaceutically acceptable excipient


OLANZAPINE PHARMACEUTICAL COMPOSITION WITH ANHYDROUS LACTOSE

(WO2008037502) 03.04.2008 A61K 47/26 SYNTHON B.V.
The invention relates to an olanzapine pharmaceutical composition such as a tablet is made using anhydrous lactose as an excipient.


METHODS FOR TASTE MASKING OF NEBULISED COMPOSITIONS FOR NASAL AND PULMONARY INHALATION THERAPY

(WO2008025560) 06.03.2008 A61K 9/12 PARI PHARMA GMBH
The invention provides pharmaceutical aerosols suitable for inhalation. The aerosols comprise a water-soluble active ingredient exhibiting a poor taste and at least one taste-masking excipient. In a further aspect, the invention provides methods to produc


POWDER FORMULATIONS FOR INHALATION CONTAINING ENANTIOMERICALLY PURE BETA-AGONISTS

(WO2008023001) 28.02.2008 A61K 31/536 BOEHRINGER INGELHEIM INTERNATIONAL GMBH
The present invention relates to powder formulations for inhalation containing enantiomerically pure compounds of general Formula (I) wherein the groups R1, R2 and R3 may have the meanings indicated in the claims and in the specification, optionally in th


HUMAN-POWERED DRY POWDER INHALER AND DRY POWDER INHALER COMPOSITIONS

(WO2008021451) 21.02.2008 A61M 15/00 AKTIV-DRY LLC
In one embodiment, a human-powered dry powder inhaler comprises a human- powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged fr


COMPOSITIONS AND DRUG-DELIVERY SYSTEMS COMPRISING RAPAMYCIN ANALOGS AND PACLITAXEL

(WO2008021124) 21.02.2008 A61K 45/06 ABBOTT LABORATORIES
The present invention provides for drug-delivery systems and compositions comprising zotarolimus and paclitaxel, or derivatives, prodrugs or salts thereof, as well as methods of treatment using such systems and compositions, wherein the drugs complement e


NEW DIRECT COMPRESSIBLE EXCIPIENT BLEND

(WO2008020990) 21.02.2008 A61K 9/20 MALLINCKRODT BAKER, INC.
A method for making a pharmaceutically acceptable tablet utilizing a pre-mixed excipient blend is provided. A universal, pre-mixed excipient blend is mixed with an active pharmaceutical ingredient to form an active pharmaceutical ingredient blend. The res


FORMULATIONS OF FLIBANSERIN AND METHOD FOR MANUFACTURING THE SAME

(WO2008019996) 21.02.2008 A61K 9/20 BOEHRINGER INGELHEIM INTERNATIONAL GMBH
The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of flibanserin and at least one pharmaceutically acceptable excipient, characterized in that said pharmaceutical release systems exhibit a pharmac


ORAL POLYVINYL ALCOHOL CAPSULES COMPRISING PROTON PUMP INHIBITORS

(WO2008018825) 14.02.2008 A61K 9/48 ASTRAZENECA AB
The present invention relates to an oral pharmaceutical dosage form comprising a proton pump inhibitor characterized in that the dosage form is in the form of a capsule comprising a pharmaceutical formulation containing a proton pump inhibitor, optionally


AEROSOLIZABLE FORMULATION COMPRISING INSULIN FOR PULMONARY DELIVERY

(WO2008013938) 31.01.2008 A61K 38/00 NEKTAR THERAPEUTICS
Aerosolizable formulations comprising: an insulin derivative having an isoelectric point (pI) ranging from about 6 to about 8; and a pharmaceutically acceptable excipient including a precipitating agent.


GASTRIC RETENTION-TYPE PELLET AND THE PREPARATION METHOD THEREOF

(WO2008010690) 24.01.2008 A61K 9/16 HANDOK PHARMACEUTICALS CO., LTD.
Disclosed herein are a gastric retention pellet, comprising: (1) an inner layer, comprising a drug and a pharmaceutically acceptable carrier; and (2) an outer layer comprising a polymer having mucoadhesive and drug release-controlling properties, as well


CONTROLLED-RELEASE FORMULATIONS

(WO2008008434) 17.01.2008 A61K 9/20 MUTUAL PHARMACEUTICAL COMPANY, INC.
Disclosed herein are controlled-release formulations which exhibit substantially zero-order release kinetics. The formulations include a core comprising a core active agent and a wax excipient substantially coated with an extended-release coating. The for


SOLID DOSE FORMULATIONS OF A THROMBIN RECEPTOR ANTAGONIST

(WO2008005352) 10.01.2008 A61K 31/343 SCHERING CORPORATION
Capsule formulations of a thrombin receptor antagonist for oral administration are disclosed. In some embodiments, the thrombin receptor antagonist is Formula (1), or a pharmaceutically acceptable isomer, salt, or solvate thereof. The formulations include


AN ORAL PHARMACEUTICAL COMPOSITION OF AN ANILINOPYRIMIDINE, ITS PREPARATION AND USE THEREOF

(WO2008003769) 10.01.2008 A61K 9/48 ARES TRADING S.A.
An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylen


PHARMACEUTICAL COMPOSITION CONTAINING A TETRAHYDROFOLIC ACID

(WO2008003432) 10.01.2008 A61K 9/20 BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
The present invention relates to solid pharmaceutical compositions, in particular to oral contraceptives, comprising a progestogen, such as drospirenone; an estrogen, such as ethinylestradiol; a tetrahydrofolic acid or a pharmaceutically acceptable salt t


MULTIPARTICULATE OSMOTIC DELIVERY SYSTEM

(WO2008001341) 03.01.2008 A61K 9/00 BIOVAIL LABORATORIES INTERNATIONAL SRL
The invention relates to a pharmaceutical composition, comprising at least one micropartide comprising at least one core which is at least partially coated with at least one osmotic subcoat, and at least one outer coat which at least partially coats the a


RABEPRAZOLE FORMULATION

(WO2008000463) 03.01.2008 A61K 9/36 LEK PHARMACEUTICALS D.D.
The present invention relates to a pharmaceutical composition of rabeprazole or a pharmaceutically acceptable salt thereof, particularly rabeprazole sodium. The subject of the invention is a stable pharmaceutical composition comprising rabeprazole sodium,
World  Patents Published  in 2009
World  Patents Published  from 1990 to 2007
PCT - World Patents in Excipients, Delivery and Release of Pharmaceutical
Compositions and Actives Published in 2008
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WORLD PATENTS IN EXCIPIENTS, DELIVERY AND RELEASE OF PHARMACEUTICAL ACTIVES PUBLISHED IN 2008
This list includes patent documents published by the World Intellectual Property Organization (WIPO). The list was retrieved by searching the claims section of all patent applications. Salient
search terms included pharmaceutical formulations, excipients, strips, gums, cellulose, lozenge, tablets, capsules, suppositories; solid dosage, nasal inhalation; time, control or sustained
drug release; polysaccharides, polymeric excipients, hyaluronic acid, micro- and nano-spheres, carbomer, povidone, polyacrylates, polymerthacrylates; emulsions; enemas, vaginal, rectal,
nasal, ocular or buccal administration of medications, etc.