US Oral Care Formulation Patent Applications Published in 2010

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US PATENT APPLICATIONS IN ORAL CARE FORMULATION PUBLISHED IN 2010



Application No.: US20100000039A1  Published: 07/Jan/2010

Title: Portabale toothbrush dispenser

Applicant/Assignee:

Application No.: 12/150788   Filing Date: 19/Jun/2008

Abstract:I claim that my Portable Toothbrush Dispenser will contain both toothbrush and clear through dispenser. The toothbrush section will contain 3 small holes for use of disbursement of equal toothpaste or gel. The Dispenser will have a mechanism lever which will help with the dispensing of product. Portable Toothbrush Dispenser will have colorful caps and will be sized in a portable way. It will fit in shirt pockets or pants just like carrying a pen. The material to make this product can be recycled plastic being that its good for the environment.

Priority:

Inventor: VEGA-CORTES BEATRIZ [US]


Application No.: US20100000995A1  Published: 07/Jan/2010

Title: Container lid having multiple utilities

Applicant/Assignee:

Application No.: 12/456540   Filing Date: 19/Jun/2009

Abstract:The prevention from hardening upon storage of paste-like material by use of a lid having an inlet port, an outlet port, and a plastic bag attached to the inlet port. By expelling the air in contact with the paste-like material, the material can be prevented from hardening during storage. A similar lid is used in a pre-cleaning device situated between a dust-producing tool and a wet/dry vacuum. Dust-laden air enters the device through an inlet port and is discharged over a water filter. The pre-cleaned air is vacuumed to a wet/dry vacuum. The pre-cleaning process lengthens the useful life of the wet/dry vacuum. A hand-held sander is disclosed which provides for rapid change of sandpaper. The sander has a hollow upper handle component and a lower surface component which are held together with a latch. Depressing of a quick-release button allows separation of the two parts.

Priority: US20080999779P Applic. Date: 2008-07-01

Inventor: YARBROUGH GLEN A [US]


Application No.: US20100001545A1  Published: 07/Jan/2010

Title: DISMANTLEABLE VEHICLE SEAT

Applicant/Assignee: INNOVATION & SAFETY, S.L

Application No.: 12/305147   Filing Date: 09/Mar/2007

Abstract:Detachable vehicle seat, with a back structure and a seat structure

coupling means for coupling the seat structure to the back structure

securing means for securing the seat structure to a part of the vehicle floor

a rapid detachment mechanism that permits the seat to be decoupled from the back

at least one first strap is coupled to the structure of the back part of the seat in a zone corresponding to the abdominal zone of the person

a headrest in which at least one second strap is coupled in a zone corresponding to the zone of the head of the person.

Priority: EP20060380174 Applic. Date: 2006-06-16; WO2007ES00131 Applic. Date: 2007-03-09

Inventor: DE RICO HERRERO SERGIO [ES]


Application No.: US20100003201A1  Published: 07/Jan/2010

Title: Silicone composition

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS, INC

Application No.: 12/217548   Filing Date: 07/Jul/2008

Abstract:This invention relates to silicone-containing compositions, method of making said silicone-containing compositions, and to personal care and other products based on such compositions.

Priority:

Inventor: WAHL ROY UWE [US]


Application No.: US20100003311A1  Published: 07/Jan/2010

Title: Antimicrobial Composition

Applicant/Assignee:

Application No.: 12/304204   Filing Date: 13/Jun/2007

Abstract:Use of a composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof, in the manufacture of a topical medicament for antimicrobial treatment of the skin or mucosa.

Priority: IT2006MI01132 Applic. Date: 2006-06-13; WO2007GB02197 Applic. Date: 2007-06-13

Inventor: MASTRODONATO MARCO [IT]


Application No.: US20100003637A1  Published: 07/Jan/2010

Title: Dental File with Improved Tip Configuration

Applicant/Assignee:

Application No.: 12/167905   Filing Date: 03/Jul/2008

Abstract:A dental instrument for cleaning and shaping a root canal of a tooth includes a working portion having three helical flutes and a guide tip with a first, second, and third face surface. A portion of the guide tip is removed so that each of the first and second surfaces are contiguous to a lateral surface of a conical-shaped envelope defining the original tip but a portion of the third surface is not contiguous to a lateral surface of the conical-shaped envelope. The intersection of the first and second surfaces, however, remains at the center point of the guide tip. The removed portion of the guide tip may result in an arcuate-shaped face surface, an angular-shaped face surface, or some combination of the two.

Priority:

Inventor: JOHNSON WILLIAM B [US]


Application No.: US20100004222A1  Published: 07/Jan/2010

Title: Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same

Applicant/Assignee: RENOVIS, INC

Application No.: 12/224357   Filing Date: 22/Feb/2007

Abstract:Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20060776106P Applic. Date: 2006-02-23; US20060775949P Applic. Date: 2006-02-23; US20060776058P Applic. Date: 2006-02-23; US20060776057P Applic. Date: 2006-02-23; US20060775930P Applic. Date: 2006-02-23; US20060776033P Applic. Date: 2006-02-23; US20060775945P Applic. Date: 2006-02-23; US20060776056P Applic. Date: 2006-02-23; US20060776105P Applic. Date: 2006-02-23; US20060839903P Applic. Date: 2006-08-24; US20060839994P Applic. Date: 2006-08-24; US20060776064P Applic. Date: 2006-02-23; WO2007US04912 Applic. Date: 2007-02-22

Inventor: KELLY MICHAEL G [US]; KAUB CARL J [US]; KINCAID JOHN [US]; JANAGANI SATYANARAYANA [US]; WU GUOXIAN [US]; WEI ZHI-LIANG [US]; SAHASRABUDHE KIRAN [US]; DUNCTON MATTHEW [US]; UPASANI RAVINDRA B [US]; FANG YUNFENG [US]; COX MATTHEW [US]; HE JIANHUA [US]


Application No.: US20100004300A1  Published: 07/Jan/2010

Title: HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/495880   Filing Date: 01/Jul/2009

Abstract:The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Priority: US20080077220P Applic. Date: 2008-07-01

Inventor: ZIMMERMANN NICOLE [US]; GROOTENHUIS PETER D J [US]; NUMA MEHDI MICHEL DJAMEL [US]; STAMOS DEAN [US]; ANDERSON COREY DON [US]; WHITNEY TARA [US]


Application No.: US20100004666A1  Published: 07/Jan/2010

Title: Oral Care Implement

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/560894   Filing Date: 16/Sep/2009

Abstract:An oral care implement with a soft tissue cleanser is provided to effectively cleanse the soft tissue of the mouth with comfort and a reduced risk of injury to the user. In one construction, a projection is formed of a combination of a hard material and a soft material. The hard material provides good stability for cleaning debris from the tongue or other tissue while the soft material provides comfort and a reduced risk of injury.

Priority: US2005-261048 Applic. Date: 2005-10-28; US2004-011605 Applic. Date: 2004-12-15; US2004-019671 Applic. Date: 2004-12-23; US2004-869922 Applic. Date: 2004-06-18; US2003-601106 Applic. Date: 2003-06-20; WO2003US30633 Applic. Date: 2003-09-26; WO2003US29497 Applic. Date: 2003-09-17; US20030189729F Applic. Date: 2003-09-10; US2004-989267 Applic. Date: 2004-11-17; US20040209242F Applic. Date: 2004-07-14; US20020414117P Applic. Date: 2002-09-27; US20020418776P Applic. Date: 2002-10-16; US20020419425P Applic. Date: 2002-10-18; US20020412290P Applic. Date: 2002-09-20

Inventor: MOSKOVICH ROBERT [US]


Application No.: US20100006121A1  Published: 14/Jan/2010

Title: Plasma cleaning method

Applicant/Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURG

Application No.: 11/794796   Filing Date: 25/Jan/2006

Abstract:The present invention relates to an improved method for cleaning using plasma In particular, the present invention relates to the plasma cleaning and decontamination of instruments for use in medicine, dentistry and food preparation whereby the soiled item is exposed to a solvent and then to a plasma, whereby this enables excitation of water within the soil itself.

Priority: GB20050001460 Applic. Date: 2005-01-25; WO2006GB00247 Applic. Date: 2006-01-25

Inventor: BAXTER ROBERT [GB]; BAXTER HELEN [GB]


Application No.: US20100008836A1  Published: 14/Jan/2010

Title: APPARATUS FOR CRACKING THE MOLECULAR STRUCTURE OF LONG CHAIN ORGANIC SUBSTANCES

Applicant/Assignee: ENERCUT S.R.L

Application No.: 12/375442   Filing Date: 13/Aug/2007

Abstract:An apparatus for cracking organic substances, for making a mixture of solid and/or liquid and/or gaseous components. The device comprises a cracking chamber (5) with substantially tubular walls arranged between an inlet port (beta) of said organic substances and an outlet port (7) of the mixture. In the chamber (5) a rotor shaft is arranged (23) associated with rotary actuating means (24) of the rotor shaft (23) with respect to the walls of the chamber in such a way that the cracking occurs by friction of the substances during the relative rotation between the rotor shaft (23) and the walls of the cracking chamber (5). A feeding device pushes the substances in the cracking chamber (5), where they are subject to a high speed mixing action owing to the rotor shaft (23), and a variable gap (S) adjusts the friction, in particular, in a first tubular section (20) of the chamber (5), so that the transformation temperature reaches a desired value. Then the products pass through the gap (S), from the first tubular section (20) to a second tubular section (21), which may have diameter larger than the first and where the transformation is completed, and then are transferred to a degassing device through the outlet port (7).

Priority: IT2006BO00603 Applic. Date: 2006-08-11; WO2007IB02335 Applic. Date: 2007-08-13

Inventor: PECCI GIORGIO [IT]


Application No.: US20100008866A1  Published: 14/Jan/2010

Title: CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES

Applicant/Assignee: NEUROGEN CORPORATION

Application No.: 12/436587   Filing Date: 06/May/2009

Abstract:Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Priority: WO2007US23318 Applic. Date: 2007-11-05; US20060864460P Applic. Date: 2006-11-06

Inventor: BLUM CHARLES A [US]; GHOSH MANUKA [US]; MARTINEZ ISAMIR [US]; ZHANG XUECHUN [US]; ZHENG XIAOZHANG [US]


Application No.: US20100010101A1  Published: 14/Jan/2010

Title: Rapid-Melt Compositions and Methods of Making Same

Applicant/Assignee: CAPRICORN PHARMA, INC

Application No.: 12/501652   Filing Date: 13/Jul/2009

Abstract:The present invention provides a novel rapid-melt pharmaceutical composition comprising a binder, a super emulsifier, a diluent/bulking material

and an active ingredient. The present invention also provides a rapid-melt bead composition comprising a binder having a melting point from about 20 to about 90 DEG C., an emulsifier

a diluent/bulking material

and an active ingredient. Further, the present invention provides a chew tablet composition comprising a binder

an emulsifier having a melting point of greater than about 40 DEG C.

a diluent/bulking material

and an active ingredient. Methods of making the disclosed compositions are also described.

Priority: US2007-818212 Applic. Date: 2007-06-12; US2002-208877 Applic. Date: 2002-08-01; US2001-898471 Applic. Date: 2001-07-05; US2001-858885 Applic. Date: 2001-05-17; US2000-610489 Applic. Date: 2000-07-05

Inventor: CHERUKURI S RAO [US]


Application No.: US20100011626A1  Published: 21/Jan/2010

Title: Double dual shoe to pant hem protector clip clamp

Applicant/Assignee:

Application No.: 12/456919   Filing Date: 24/Jun/2009

Abstract:Double dual shoe to hem protective clip clamp prevents a baggy pant hem from dragging on the ground by attaching one clamp to the pant hem, with the other clamp attaching directly onto the shoe heel rim. The device is made of two components, an upper clamp and a lower clamp, which may be attached permanently, or may be interchanged for versatility.

Priority: US2008-148359 Applic. Date: 2008-04-13; US20070925891P Applic. Date: 2007-04-23; US20070925892P Applic. Date: 2007-04-23; US20070925889P Applic. Date: 2007-04-23; US20070925866P Applic. Date: 2007-04-23; US20070925887P Applic. Date: 2007-04-23; US20070925890P Applic. Date: 2007-04-23

Inventor: ALI CECELIA ELAINE [US]; BROMELL LORENZO ALEXIS [US]


Application No.: US20100012221A1  Published: 21/Jan/2010

Title: Water refilling assembly for hydro pack

Applicant/Assignee:

Application No.: 12/219184   Filing Date: 17/Jul/2008

Abstract:A hydro pack includes a water bag with a handle on a top end thereof and a outlet frame is located on a lower end of the water bag. A connection member is connected with the outlet frame and a hose with semi-circular cross section is connected to the connection member. The other end of the hose is connected with a female unit. A universal mouth piece assembly, a bottle water connector, a faucet connector, a filtering unit and a suction unit each have a male part which is optionally connected with the female unit so as to conveniently and quick refill clean water in the water bag.

Priority:

Inventor: LIEN CHIEN-PING [TW]


Application No.: US20100012615A1  Published: 21/Jan/2010

Title: Bottle Closure with Two Interlocking Parts One Fitting Over the Other

Applicant/Assignee: ZORK PTY LTD

Application No.: 12/377786   Filing Date: 17/Aug/2007

Abstract:The present invention describes a bottle closure for bottles containing liquids at high pressure, such as bottles of sparkling wine, the closure having a first part and a second part, the first part having a portion adapted to receive a portion of an upper section of a neck of the bottle, and a second part that fits substantially over the first part, which is relatively movable with respect to the first part and has at least two positions, a first of which is in a free position and a second of which is in an interlocking position whereby a portion of the second part urges against a portion of the first part receiving the upper section of the neck of the bottle so as to be engaging against an outer side of the said first part to hold it thereby to resist release from its interlocking position with respect to the said neck of an industry standard bottle.

Priority: AU20060904443 Applic. Date: 2006-08-17; WO2007AU01161 Applic. Date: 2007-08-17

Inventor: BROOKS JOHN [AU]


Application No.: US20100012687A1  Published: 21/Jan/2010

Title: INTERNAL CONTAINER BORE MOUNT FITMENT

Applicant/Assignee: PORTOLA PACKAGING, INC

Application No.: 12/520459   Filing Date: 21/Dec/2007

Abstract:In an embodiment of the invention there is provided a membrane fitment designed and sized to be inserted into the orifice defined by a container. Retention structure on the fitment cooperates with complimentary structure on the internal wall of the container orifice to secure the fitment within the orifice such that the combination forms an excellent primary seal. Tamper evidence is offered by the normal requirement for initial membrane removal. Novel designs for the membrane, its associated pull ring, and the frangible removal structure are taught in various embodiments. The novel designs may promote facile initial removal suitable for a child. In addition, the novel designs avoid the potential hazards presented by prior art membranes.

Priority: US20060871723P Applic. Date: 2006-12-22; WO2007US88538 Applic. Date: 2007-12-21

Inventor: LOHRMAN RICHARD [US]; HENNESSY THOMAS [US]; KIM SUNGSUK STEVE [US]


Application No.: US20100012892A1  Published: 21/Jan/2010

Title: Tooth Whitening Compositions and Methods

Applicant/Assignee: BASF CATALYSTS LLC

Application No.: 12/502907   Filing Date: 14/Jul/2009

Abstract:A non-cytotoxic chlorine dioxide composition and a mixed agent bleaching composition for tooth whitening are disclosed. Methods of use are also provided.

Priority: US20080135011P Applic. Date: 2008-07-15; US20080106026P Applic. Date: 2008-10-16; US20090150685P Applic. Date: 2009-02-06

Inventor: SPERONELLO BARRY KEVEN [US]; CASTELLANA FRANK S [US]; HRATKO LINDA [US]


Application No.: US20100013154A1  Published: 21/Jan/2010

Title: Board game system for teaching and promoting proper hygiene

Applicant/Assignee:

Application No.: 12/218336   Filing Date: 15/Jul/2008

Abstract:This invention relates to an educational device employing a board game system to teach basic hygiene concepts, routines and processes to both children and developmentally challenged individuals. The educational board game consists of a playing field with a plurality of spaces that define a path of travel and specific hygiene tasks which require simulation by the players. Movement about the game board is facilitated by a random selection from a numerical value and special instruction deck of playing cards. Each time a player can correctly identify the steps necessary to complete a hygiene task properly and in correct order they receive an "Artifact" card. The first player to collect all six "Artifact" cards by completing all six of the hygiene task simulations and is the first to reach the center of the playing board wins the game.

Priority:

Inventor: WULF PAUL ARTHUR [US]; WULF DEBRA ANN [US]


Application No.: US20100014209A1  Published: 21/Jan/2010

Title: HIGH EFFICIENCY GAS LIGHTING DEVICE FOR AN ELECTRIC HOUSEHOLD APPLIANCE, IN PARTICULAR A COOKING RANGE

Applicant/Assignee:

Application No.: 12/529326   Filing Date: 25/Mar/2008

Abstract:A gas lighting device including: a body formed by an electrically insulating material carrying a plurality of high-voltage outputs for the connection of spark generating means

a transformer accommodated in the body and including a primary winding wound around and carried by a ferromagnetic material core, a carrying element formed by an electrically insulating material and designed to contain the primary winding therein, and a secondary winding consisting of a plurality of coils externally carried by the carrying element, electrically insulated from the primary winding and essentially coaxial with the latter

the core is ring-shaped on a plane parallel to an axis (A) of the windings and consists of two half rings reciprocally coupled and arranged facing and closely adjacent to each other in the direction of the axis of the windings

a first circumferential portion of the ring-shaped core, formed by one or both of the half rings, is accommodated inside the carrying element so as to be surrounded by the windings, while a second circumferential portion of the core is formed parallel to the first and radially on the outside of the windings so as not to be surrounded by the same.

Priority: IT2007TO00217 Applic. Date: 2007-03-26; WO2008IB00696 Applic. Date: 2008-03-25

Inventor: PIANEZZE DANIELE [IT]; ALEARDI MASSIMO [IT]


Application No.: US20100015068A1  Published: 21/Jan/2010

Title: Methods and Compositions For Altering Biological Surfaces

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 12/309049   Filing Date: 06/Jul/2007

Abstract:Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.

Priority: US20060818509P Applic. Date: 2006-07-06; WO2007US15525 Applic. Date: 2007-07-06

Inventor: KARP JEFFREY M [US]; KHADEMHOSSEINI ALIREZA [US]; BERRY DAVID A [US]; LANGER ROBERT S [US]; GU FRANK X [US]


Application No.: US20100015116A1  Published: 21/Jan/2010

Title: Designer Ubiquitin Ligases For Regulation Of Intracellular Pathogenic Proteins

Applicant/Assignee:

Application No.: 12/482420   Filing Date: 10/Jun/2009

Abstract:The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes

and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.

Priority: US20080060324P Applic. Date: 2008-06-10

Inventor: OYLER GEORGE A [US]; TSAI YIEN CHE [US]


Application No.: US20100015187A1  Published: 21/Jan/2010

Title: MACRO-SIZED LIPID CAPSULE EMULSION COMPOSITION AND COSMETIC COMPOSITION CONTAINING THE SAME

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 12/300251   Filing Date: 30/Nov/2006

Abstract:An emulsion composition of the invention has macro-sized (0.01 to 5 mm) lipid capsule particles and it is for a skin cosmetic composition. An emulsion composition of the invention exhibits improved stability for its particle size by adjusting a size of the particle through a combination of liquid phase oil and integument lipid or lipoid material and encapsulating the liquid phase oil with the integument lipid. The emulsion composition of the invention has unique outward appearance and use feeling due to the macro-sized particles in it, also exhibits excellent skin safety and moisture persistence by containing no surfactant and maintains an activity of an oleophilic effective ingredient which is apt to be oxidized for a long time.

Priority: KR20060042420 Applic. Date: 2006-05-11; WO2006KR05111 Applic. Date: 2006-11-30

Inventor: KANG CHAN KOO [KR]; KANG HAK HEE [KR]; PARK CHANG HOON [KR]; HAN SANG HOON [KR]


Application No.: US20100015207A1  Published: 21/Jan/2010

Title: Methods for Treating Oral Cavity Infections with Chlorine Dioxide

Applicant/Assignee: BASF CATALYSTS LLC

Application No.: 12/502913   Filing Date: 14/Jul/2009

Abstract:Methods, devices, compositions, and systems for the alleviation of oral tissue infections by administration of chlorine dioxide are provided.

Priority: US20080135011P Applic. Date: 2008-07-15; US20080106026P Applic. Date: 2008-10-16; US20090150685P Applic. Date: 2009-02-06; US20090187198P Applic. Date: 2009-06-15

Inventor: SPERONELLO BARRY KEVEN [US]; CASTELLANA FRANK S [US]


Application No.: US20100015245A1  Published: 21/Jan/2010

Title: Combination of Copper Cations with Peroxides or Quaternary Ammonium Compounds for the Treatment of Biofilms

Applicant/Assignee:

Application No.: 12/428747   Filing Date: 23/Apr/2009

Abstract:The present invention relates to a method of inhibiting biofilms by combinations of antimicrobials, particularly with their synergistic activity against bioFilms. The antimicrobials include combination of copper ion and quaternary ammonium compound or combination of copper ion and peroxide. The invention also include methods for inhibiting biofilm-induced microbial corrosion or fouling.

Priority: US20080047634P Applic. Date: 2008-04-24

Inventor: HARRISON JOE [CA]; TURNER RAYMOND [CA]; CERI HOWARD [CA]


Application No.: US20100015566A1  Published: 21/Jan/2010

Title: Shower head attachment for mixing liquids used to clean teeth

Applicant/Assignee:

Application No.: 12/586441   Filing Date: 22/Sep/2009

Abstract:A valve for adjusting the flow of water through an oral irrigation device is connected to a shower head by a flexible conduit. The valve is located on a handle connected to a water-dispensing pick for cleaning teeth and gums. Mixing apparatus is provided for injecting a secondary fluid, such as a mouthwash, into the flexible conduit upstream from the pick in a direct stream from the shower head.

Priority: US2007-900763 Applic. Date: 2007-10-15

Inventor: SHAW DANIEL A [US]


Application No.: US20100015574A1  Published: 21/Jan/2010

Title: Aesthetic ceramic veneered restoration

Applicant/Assignee:

Application No.: 12/384290   Filing Date: 02/Apr/2009

Abstract:The present invention relates to an aesthetic dental restoration having a layered structure, which dental restoration has the appearance of a natural tooth. In addition, the present invention relates to a method for preparing such dental restorations. Particularly, the invention is based on the control of interaction between opalescence and fluorescence.

Priority: EP20020078949 Applic. Date: 2002-09-20; US2006-544681 Applic. Date: 2006-10-06; US2003-668552 Applic. Date: 2003-09-22

Inventor: VAN DER ZEL JOSEPH MARIA [NL]; APPLEMAN PETRUS GERARDUS [NL]; CORNELISSEN ERIC MARINUS HERMANUS [NL]; DE KLER MARCEL ANDRE [NL]; GEBHARDT JURGEN [DE]


Application No.: US20100015576A1  Published: 21/Jan/2010

Title: METHOD AND APPARATUS FOR DIAGNOSTIC AND TREATMENT USING HARD TISSUE OR MATERIAL MICROPERFORATION

Applicant/Assignee: REJUVEDENT LLC

Application No.: 12/503990   Filing Date: 16/Jul/2009

Abstract:A method of modifying or treating biological tissue by microperforating hard tissue is disclosed. The method comprises identifying a target area associated with the hard tissue, using a laser beam to perforate at least one incision in the hard tissue, wherein at least one incision has a diameter from a range of 0.001 mm to 0.5 mm and an aspect ratio from a range of 1 to 100 times, introducing a treatment substance into the incision, and causing the treatment substance to interact with the target area. Also a device for microperforating hard biological tissue is disclosed, comprising a laser pump system and a laser head coupled to the laser pump system for generating a pulsed laser having ranges of wavelengths, a pulse duration, pulse energy from a selected range, a beam divergence factor less than 5, a repetition rate higher than 50 Hz

and a beam delivery system comprised of a focusing system for creating a beam having a diameter from a range of 0.001 mm to 0.5 mm.

Priority: WO2008US51241 Applic. Date: 2008-01-16; US20070885009P Applic. Date: 2007-01-16

Inventor: ALTSHULER GREGORY B [US]; BELIKOV ANDREY V [RU]; FELDCHTEIN FELIX I [US]; TUCHIN VALERY V [RU]; VYBORNOV ALEXANDER G [US]


Application No.: US20100015578A1  Published: 21/Jan/2010

Title: METHODS OF USING A DENTAL COMPOSITION HAVING AN ACIDIC COMPONENT AND A PHOTOBLEACHABLE DYE

Applicant/Assignee:

Application No.: 12/517739   Filing Date: 12/Dec/2007

Abstract:Methods of using a dental composition having a photobleachable dye and an acidic component with a pKa of less than 4.5 are disclosed. The photobleachable dye is selected from the group consisting of aminoanthraquinone dyes, azo dyes, and combinations thereof. The aged color of the dental composition is substantially the same as the color of the dental composition immediately after hardening.

Priority: US20060869741P Applic. Date: 2006-12-13; WO2007US87192 Applic. Date: 2007-12-12

Inventor: FALSAFI AFSHIN [US]; OXMAN JOEL D [US]; TON TIFFANY T [US]; BRENNAN JOAN V [US]; CINADER JR DAVID K [US]; VELAMAKANNI BHASKAR V [US]; MITRA SUMITA B [US]


Application No.: US20100016438A1  Published: 21/Jan/2010

Title: Granulated crystal compilation composed of pure organic minerals used in all food applications resulting in energy supplementation, diet and weight regulation, and medicinal effects

Applicant/Assignee:

Application No.: 12/153790   Filing Date: 19/Jul/2008

Abstract:A composition made of pure natural minerals that can be used in all food applications resulting in energy supplementation, diet and weight regulation, and medicinal benefits.

Priority:

Inventor: HASSANI DANIEL [US]


Application No.: US20100016462A1  Published: 21/Jan/2010

Title: Long-Lasting Gustatory and/or Olfactory Aversion Veterinary Compositions for Behavior Modification

Applicant/Assignee:

Application No.: 12/499899   Filing Date: 09/Jul/2009

Abstract:Disclosed herein are gustatory and/or olfactory aversion compositions comprising one or more bitterants and appropriate adhesives or tackifiers, and the like, which provide a long-lasting effect. The compositions are useful for behavior modification, especially in animals, such as pets or livestock.

Priority: US20080081531P Applic. Date: 2008-07-17

Inventor: CLEMENT RICHARD J [US]; CLEMENT-FRAZIER KATI [US]


Application No.: US20100016464A1  Published: 21/Jan/2010

Title: DENTAL COMPOSITIONS WITH NATURAL TOOTH FLUORESCENCE

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/520402   Filing Date: 21/Dec/2007

Abstract:The invention features a dental composition containing a polycyclic aromatic compound, such as 2-ethyl 9,10-dimethoxy anthracene (EDMOA), in an amount that provides the composition with fluorescence mimicking that of natural teeth.

Priority: US20060877513P Applic. Date: 2006-12-28; WO2007US88528 Applic. Date: 2007-12-21

Inventor: CRAIG BRADLEY D [US]; KOBUSSEN GREGORY A [US]


Application No.: US20100016879A1  Published: 21/Jan/2010

Title: TUBULAR SHAFT INSTRUMENT

Applicant/Assignee:

Application No.: 12/444336   Filing Date: 26/Sep/2007

Abstract:The present application relates to a tubular shaft instrument for separating tissue. The invention relates to a tubular shaft instrument that results in more reliable, cleaner separation of tissue. To achieve this, in contrast to conventional cutting devices, the blade is not displaced through the fixed tissue, but glides over the latter until a complete separation is ascertained.

Priority: DE200610046919 Applic. Date: 2006-10-05; DE200610046920 Applic. Date: 2006-10-05; DE200610047204 Applic. Date: 2006-10-05; DE200610047215 Applic. Date: 2006-10-05; DE200610056405 Applic. Date: 2006-11-29; DE200610059175 Applic. Date: 2006-12-14; WO2007EP08389 Applic. Date: 2007-09-26

Inventor: HAFNER DIETER [DE]


Application No.: US20100018162A1  Published: 28/Jan/2010

Title: Methods for the Joint Wrapping of Bags with their Contents, Applying Machine and Packet of Bags Containing "Snack" thus Obtained

Applicant/Assignee:

Application No.: 12/439777   Filing Date: 04/Sep/2007

Abstract:Method for the joint wrapping of bags containing a product in pieces, granules or powder piled inside an elongated laminar wrapping made of termo-adherent plastic and joined at its longitudinal edges forming a sleeve closed at its bottom and at its laminar header wall with weldings, which comprises: a) making the bags laid on a conveyor go forward

b) delivering at least a first bag on a support while welding means close the laminar wrapping determining a bottom

c) partially forming a continuous laminar wrapping closed longitudinally with the shape of a sleeve with its bottom welded according to step b)

d) pushing horizontally at least the first bag of the support towards the opening of the tube that forms the sleeve

e) pushing vertically causing the joint descent of the first bag and wrapping while the sleeve is closed with seams in longitudinal sense at one of its sides

f) continuing feeding the support with bags pushing them first horizontally on the opening of the tube that forms the sleeve and then vertically for the descent of the group until the packet is complete

and y g) closing by means of transverse welding the header laminar wall of the packet formed and separate it through a cut forming at the same time the bottom of the wrapping of the next packet. Machine to carry out the method. Method for the joint wrapping of bags containing "snack" inside a laminar wrapping made of thermo-adherent plastic with the shape of a sleeve, machine for carrying out such method and packet of bags containing "snack" obtained by means of such method.

Priority: AR2006P103859 Applic. Date: 2006-09-04; AR2007P103892 Applic. Date: 2007-09-03; WO2007IB02548 Applic. Date: 2007-09-04

Inventor: CARMELO CALVANO FERRUCCHIO [AR]


Application No.: US20100018533A1  Published: 28/Jan/2010

Title: Novel Device

Applicant/Assignee:

Application No.: 11/778104   Filing Date: 16/Jul/2007

Abstract:A face mask comprising a filter material being a fibrous substrate, especially non-woven polypropylene or polyester, having an acidic polymer, especially of the Carbopol or Gantrez type, deposited on the fibres. The mask has an anti-viral activity against inhaled or exhaled air. A filter material suitable for such a mask, and a process for making it are also described.

Priority: GB20060014251 Applic. Date: 2006-07-18; GB20070006435 Applic. Date: 2007-04-02

Inventor: BIEDERMANN KIMBERLY [US]; DENG FRANK [US]; KING SIMON [GB]; MIDDLETON ANDREW [GB]


Application No.: US20100018540A1  Published: 28/Jan/2010

Title: SMOKELESS TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/180763   Filing Date: 28/Jul/2008

Abstract:A smokeless tobacco product is provided. A tobacco product configured for insertion into the mouth of a user of that product comprises a tobacco formulation including a granular tobacco composition enclosed within a water-permeable pouch that has been treated with a substance selected from the group consisting of: an analgesic, a buffer, a coloring, an effervescent, or an organic acid.

Priority:

Inventor: DOOLITTLE DAVID JAMES [US]; ARZONICO BARBARA WALKER [US]; CHAPMAN PAUL STUART [US]; STOKES CYNTHIA STEWART [US]


Application No.: US20100018541A1  Published: 28/Jan/2010

Title: SMOKELESS TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/180943   Filing Date: 28/Jul/2008

Abstract:A smokeless tobacco product is provided. A tobacco product configured for insertion into the mouth of a user of that product comprises a water-permeable pouch containing a tobacco formulation that includes a granular tobacco composition and miraculin.

Priority:

Inventor: GERARDI ANTHONY RICHARD [US]; COLEMAN III WILLIAM MONROE [US]; PHILLIPS PERCY DENOID [US]


Application No.: US20100018547A1  Published: 28/Jan/2010

Title: ORAL HYGIENE DEVICE

Applicant/Assignee: FLOSSPIK PTV LTD

Application No.: 12/527192   Filing Date: 14/Feb/2008

Abstract:An oral hygiene device (10) comprising first and second parts (46,47), the first part (46) comprising a hollow body portion which encloses dental floss (64) and the other part (47) defining a toothpick, the dental floss(64) being attached to the first and second parts (46,47), the first part (47) being separable from the second part (46) so that the parts (46, 47) can act as handles between which the dental floss (64) can be tensioned. The part (46) may have ribs (54) on at least one face for enhancing gripping and also to enable the device (10) to be used as a tongue cleaner or scraper. The first part (46) may also carry a capsule (60 which can contain a liquid such as a mouth wash or breath freshener or a solid substance such as a lozenge.

Priority: AU20070900708 Applic. Date: 2007-02-14; AU20070905473 Applic. Date: 2007-10-05; WO2008AU00180 Applic. Date: 2008-02-14

Inventor: ROEMUSS PETER ANTHONY [AU]


Application No.: US20100021510A1  Published: 28/Jan/2010

Title: NEURONAL EXOCYTOSIS INHIBITING PEPTIDES

Applicant/Assignee: LIPOTEC, S.A

Application No.: 12/447136   Filing Date: 24/Oct/2007

Abstract:The invention relates to peptides of general formula (I): R1-AA-R2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group

and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.

Priority: ES20060002720 Applic. Date: 2006-10-25; WO2007ES00603 Applic. Date: 2007-10-24

Inventor: CARRENO SERRAIMA CRISTINA [ES]; PONSATI OBIOLS BERTA [ES]; VAN DEN NEST WIM [ES]; FERNANDEZ CARNEADO JIMENA [ES]; FERRER MONTIEL ANTONIO [ES]; CEBRIAN PUCHE JUAN [ES]; ALMINANA DOMENECH NURIA [ES]


Application No.: US20100021545A1  Published: 28/Jan/2010

Title: INJECTABLE IN SITU SELF-FORMING MINERAL-POLYMER HYBRID COMPOSITION AND USES THEREOF

Applicant/Assignee: BIOSYNTECH CANADA INC

Application No.: 12/575788   Filing Date: 08/Oct/2009

Abstract:Self-forming hybrid compositions consisting in admixed liquid and solid components enable the formation of bio-materials. The present invention proposes a) a thermo-sensitive self-forming liquid component, being water-based and containing at least a polycationic polymer such as chitosan, and an organic mono-phosphate source, which is a solution at a pH ranging from 6.5 to 7.4

b) a solid component being mineral and composed of at least one of calcium, fluoride, strontium, carbonate and phosphate salts. Solid mineral salts preferentially have a recognized bioactive potential such as the calcium phosphate salts for bones. Both solid and liquid components are admixed to form an injectable liquid slurry or pre-gelled paste that turn in situ into a hybrid uniform gel-like bio-material.

Priority: US2002-149053 Applic. Date: 2002-12-03; WO2000CA01492 Applic. Date: 2000-12-08; US19990169954P Applic. Date: 1999-12-09

Inventor: CHAPUT CYRIL [CA]; CHENITE ABDELLATIF [CA]


Application No.: US20100022531A1  Published: 28/Jan/2010

Title: NOVEL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF

Applicant/Assignee: RENOVIS, INC

Application No.: 11/991485   Filing Date: 01/Sep/2006

Abstract:Compounds are disclosed that have a formula represented by the following (1), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20050713231P Applic. Date: 2005-09-01; US20050714676P Applic. Date: 2005-09-07; US20050717463P Applic. Date: 2005-09-15; US20050753957P Applic. Date: 2005-12-23; US20050754223P Applic. Date: 2005-12-28; WO2006US34236 Applic. Date: 2006-09-01

Inventor: KINCAID JOHN [US]; CAO YEYU [US]; KAUB CARL [US]; LONERGAN DAVID [US]; KELLY MICHAEL G [US]


Application No.: US20100022676A1  Published: 28/Jan/2010

Title: PHOTOCURABLE COMPOSITIONS COMPRISING A PHOTOINITIATOR OF THE PHENYLGLYOXYLATE TYPE

Applicant/Assignee:

Application No.: 12/442779   Filing Date: 24/Sep/2007

Abstract:The invention provides a uv-curable colored composition, comprising (a) at least one selected ethylenically unsaturated photopolymerizable compound

(b) at least one selected curing agent

and (c) at least one selected colorant.

Priority: EP20060121655 Applic. Date: 2006-10-03; WO2007EP60093 Applic. Date: 2007-09-24

Inventor: ROGERS JONATHAN [US]; BENKHOFF JOHANNES [CH]; POWELL KARIN [DE]; JUNG TUNJA [DE]; DIETLIKER KURT [CH]; HAYOZ PASCAL [CH]; BIRBAUM JEAN-LUC [CH]; VOGEL THOMAS [DE]; HUESLER RINALDO [CH]


Application No.: US20100022681A1  Published: 28/Jan/2010

Title: Dental compositions comprising cisacrylamides and use thereof

Applicant/Assignee:

Application No.: 12/586789   Filing Date: 28/Sep/2009

Abstract:The invention concerns a dental composition comprising bisacrylamides that are polymerizable by free-radical polymerization and by Michael-addition polymerization with amines. The application of polymerization and addition polymerization with amines opens the possibility to completely reacted materials that have no oxygen inhibited layers. The claimed bisacrylamides have an improved hydrolytic stability.

Priority: US2007-699597 Applic. Date: 2007-01-29; US2002-308564 Applic. Date: 2002-12-03; US2001-925173 Applic. Date: 2001-08-09; US20010310572P Applic. Date: 2001-08-07; US20000224670P Applic. Date: 2000-08-11

Inventor: WALZ UWE [DE]; KLEE JOACHIM E [DE]


Application No.: US20100022682A1  Published: 28/Jan/2010

Title: Dental adhesive composition

Applicant/Assignee:

Application No.: 12/386022   Filing Date: 13/Apr/2009

Abstract:Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10

R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group

L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group

b is an integer of from 1 to 10

R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1

provided that at least one of R1 and R2 is not hydrogen

(ii) one or more polymerizable N-substituted alkyl acrylic or acrylic acid amide monomers

(iii) an organic water-miscible solvent and/or water

(iv) a polymerization initiator

(v) an inhibitor and/or a stabilizer

(vi) optionally an organic or inorganic acid

and (vii) optionally a filler and/or a fluoride releasing compound.

Priority: WO2007EP08764 Applic. Date: 2007-10-09; EP20060021540 Applic. Date: 2006-10-13

Inventor: KLEE JOACHIM E [DE]; LEHMANN UWE [DE]


Application No.: US20100022944A1  Published: 28/Jan/2010

Title: METHOD AND APPARATUS FOR TREATING AN ACUTE MYOCARDIAL INFARCTION

Applicant/Assignee:

Application No.: 12/506620   Filing Date: 21/Jul/2009

Abstract:A method and apparatus for treating an acute myocardial infarction is provided. The apparatus comprises an ultrasound catheter that can be inserted into the esophagus to deliver ultrasound energy to the heart and coronary vasculature. The ultrasound energy can enhance the effect of an intravenously administered thrombolytic drug on a blood clot within the coronary vasculature. The ultrasound catheter can have a means for promoting acoustic coupling with the esophagus and a means for preventing or reducing aspiration of fluids into the lungs.

Priority: US20080082443P Applic. Date: 2008-07-21

Inventor: WILCOX ROBERT L [US]


Application No.: US20100022981A1  Published: 28/Jan/2010

Title: SELF-CONTAINED DISPOSABLE CHANGING MAT

Applicant/Assignee:

Application No.: 12/448122   Filing Date: 03/Dec/2007

Abstract:A self-contained disposable changing mat (2) that is one piece and liquid proof and comprises at least two layers (4, 6) each with an absorbent working area (8) from which a part of a person is able to be attended to, a waste disposal bag (10) that hangs down when the self-contained disposable changing mat (2) is used on a raised work surface (12), the waste disposal bag (10) having a mouth (18) that gapes open so that the waste disposal bag (10) is ready for receiving waste produced during use of the self-contained disposable changing mat (2), the layers (4, 6) being partially separable from each other and connected together in or adjacent to the mouth (18) of the waste disposal bag (10) whereby an upper used layer is able to be placed in the waste disposal bag (10) in order to expose a clean lower layer available for further use during treatment of the person, and sealing means (20)

for sealing the waste disposal bag (10) after use thereby containing the waste.

Priority: GB20060025105 Applic. Date: 2006-12-15; GB20070002554 Applic. Date: 2007-02-09; WO2007GB04619 Applic. Date: 2007-12-03

Inventor: GOODMAN MICHAEL STEPHEN [GB]; MOIR GRAEME CHRISTOPHER [GB]


Application No.: US20100024683A1  Published: 04/Feb/2010

Title: PHOSPHATE COMPOUND, METAL SALT THEREOF, DENTAL MATERIAL AND DENTAL COMPOSITION

Applicant/Assignee: MITSUI CHEMICALS, INC

Application No.: 12/441468   Filing Date: 26/Sep/2007

Abstract:The invention provides a phosphate compound having an unsaturated double bond and a metal salt thereof

a dental material containing a phosphate compound having an unsaturated double bond and/or a metal salt thereof

and a dental composition containing a phosphate compound having an unsaturated double bond and/or a metal salt thereof. The phosphate compound of the invention provides a dental material and a dental composition such as a bonding material, adhesive material and a dental luting agent that are highly stable during storage, convenient for handling, and that exhibit higher adhesiveness and bond durability.

Priority: JP20060261598 Applic. Date: 2006-09-27; WO2007JP68639 Applic. Date: 2007-09-26

Inventor: TAKAGI MASATOSHI [JP]; OTSUJI ATSUO [JP]; NAGATOMO AKINORI [JP]; SUESUGI KOUJI [JP]


Application No.: US20100025355A1  Published: 04/Feb/2010

Title: CHILD-RESISTANT CANISTER

Applicant/Assignee: BERRY PLASTICS CORPORATION

Application No.: 12/507557   Filing Date: 22/Jul/2009

Abstract:A child-resistant canister includes a container and a closure configured to mount on the container to close an opening into an interior region formed in the container. The closure includes a lid and a lid anchor coupled to the lid. The lid anchor is configured to mate with a closure retainer included in the container to retain the closure in a mounted position on the container.

Priority: US20080083419P Applic. Date: 2008-07-24

Inventor: BEECROFT W GORDON [US]


Application No.: US20100025429A1  Published: 04/Feb/2010

Title: Three Seal Sachet With A Dispensing Device

Applicant/Assignee:

Application No.: 12/533023   Filing Date: 31/Jul/2009

Abstract:A three seal sachet and method of manufacturing the sachet. The sachet includes a film having first and second longitudinal sheet edges and opposed first and second sheet faces. The film is folded to form opposed first and second sachet faces where the film is sealed to itself along marginal portions of the first and second longitudinal sheet edges on the first sheet face thereby forming a tube with a longitudinal seal on the second sachet face. First and second transverse seals bond the film along the marginal portions of the first and second transverse edges of the sheet, thereby closing the tube at each end. The sachet also includes a dispensing device disposed on the first or second face. The disposed device includes a flange which is inserted into the first sachet face and secures the device to the sachet and a dispensing orifice enabling product to be dispensed from the sachet.

Priority: EP20080161590 Applic. Date: 2008-07-31

Inventor: AGER COLIN DENNIS [GB]; BURFIEND JAMES RICHARD [GB]; CAUWOOD PETER DAVID [GB]; CUCKNELL ALAN JOHN EDWARD [GB]; THOMPSON KEITH PAUL [GB]


Application No.: US20100028321A1  Published: 04/Feb/2010

Title: DRUG TARGET FOR PREVENTING AND TREATING PERIODONTAL DISEASE, IMPROVING HEALING OF PERIODONTAL WOUNDS AND PROMOTING ORAL HEALTH

Applicant/Assignee: OMNIO HEALER AB

Application No.: 12/439516   Filing Date: 28/Aug/2007

Abstract:The present invention relates to the use of a component of the plasminogen-activating pathway and use of compounds which have the capacity to activate plasminogen directly or via the plasminogen-activating pathway, for prophylaxis, prevention and treatment of periodontal disease including peri-implantitis, healing of periodontal wounds and prompting oral health in human and non-human subjects.

Priority: US20060823665P Applic. Date: 2006-08-28; US20070944111P Applic. Date: 2007-06-15; WO2007SE50586 Applic. Date: 2007-08-28

Inventor: NY TOR [SE]; LI JINAN [SE]; GUO YONGZHI [SE]; LINDH TOMAS [SE]


Application No.: US20100028371A1  Published: 04/Feb/2010

Title: Preparation of recombinant rotavirus proteins in milk of transgenic non-human mammals

Applicant/Assignee: BIOPROTEIN TECHNOLOGIES

Application No.: 10/591538   Filing Date: 04/Mar/2005

Abstract:The present invention relates to a non-human transgenic mammal whose genome comprises: i) a first transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding a rotavirus protein selected from VP2, VP4, VP6 and VP7 and wherein said cDNA comprises a secretion signal sequence

ii) at least a second transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding another said rotavirus protein and wherein said cDNA comprises a secretion signal sequence

and wherein said rotavirus proteins are secreted separately and auto-assembled in milk in rotavirus like particles (VLP) or aggregates of said rotavirus proteins.

Priority: EP20040290589 Applic. Date: 2004-03-04; WO2005IB00896 Applic. Date: 2005-03-04

Inventor: COHEN JEAN [FR]; SOLER ERIC [FR]; HOUDEBINE LOUIS-MARC [FR]; SCHWARTZ-CORNIL ISABELLE [FR]; FOURGEUX CYNTHIA [FR]; PAREZ NATHALIE [FR]; GARBARG-CHENON ANTOINE [FR]; COHEN IVAN [FR]; COHEN SERGE [FR]


Application No.: US20100028436A1  Published: 04/Feb/2010

Title: POLYMER MATRIX, USES THEREOF AND A METHOD OF MANUFACTURING THE SAME

Applicant/Assignee: BACTIGUARD AB

Application No.: 12/303554   Filing Date: 05/Jun/2007

Abstract:The present invention relates to a polymer matrix, characterized in that it comprises a) an electron donating constituent and b) metal particles comprising at least one metal chosen from palladium, gold, ruthenium, rhodium, osmium, iridium, and platinum. The polymer matrix makes it possible to improve the biocompatibility and antimicrobial properties of substrates coated with said polymer matrix.

Priority: US20060811305P Applic. Date: 2006-06-05; WO2007SE00543 Applic. Date: 2007-06-05

Inventor: OHRLANDER MATTIAS [SE]; SOEDERVALL BILLY [SE]


Application No.: US20100028524A1  Published: 04/Feb/2010

Title: Low fat meat compositions capable of high temperature cooking

Applicant/Assignee:

Application No.: 12/587477   Filing Date: 08/Oct/2009

Abstract:Low fat meat compositions are provided that contain ingredients that act synergistically, allowing the compositions to successfully cook and surface char at temperatures of 700 degrees Fahrenheit and above, in one step, consisting of meat, water, textured protein concentrate, water binders, a fat binder/emulsifier/dispersion agent, and salt. These compositions reproduce the mouth-feel, taste, and texture of 100% meat char-broiled in the same manner. The invention makes possible high temperature cooking of meat compositions at lower fat content, far less than 19%, which was not possible prior to this invention. The preferred embodiment reduces the percentage of fat to a range of 9-11.25%, plus a negligible amount of fat from the non-meat ingredients, and this compares very favorably to 22% fat content stated as the optimum requirement, by the Nieco Company, manufacturer of high temperature broilers. The benefits of the invention are reduced fat content as a dietary consideration, food that is easier to digest and maximized for taste, capable of being cooked in one easy low cost step, a substantial reduction of greenhouse gases, particulate matter and volatile organic compounds caused by char-cooking of meats containing higher fat content, and less overall need for animal meat, which translates into reduced greenhouse gases cause by live animals. The invention contributes to worldwide efforts to reduce global warming.

Priority: US2008-008878 Applic. Date: 2008-01-15

Inventor: STRAM MICHAEL A [US]; STRAM JR THEODORE M [US]


Application No.: US20100028527A1  Published: 04/Feb/2010

Title: Process for Coating Dental Tape

Applicant/Assignee:

Application No.: 12/185337   Filing Date: 04/Aug/2008

Abstract:This present invention relates to a process for evenly and uniformly coating textured tape (e.g., dental tape).

Priority: US20080085345P Applic. Date: 2008-07-31

Inventor: OCHS HAROLD [US]; CHODZKO JOHN [US]


Application No.: US20100028823A1  Published: 04/Feb/2010

Title: Anti-microbial orthodontic compositions and appliances and methods of production and use thereof

Applicant/Assignee:

Application No.: 12/460046   Filing Date: 13/Jul/2009

Abstract:The presently disclosed and claimed invention is directed to anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions comprising an effective amount of a selenium compound, kits containing same, and methods of producing and using said anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions.

Priority: US2006-439751 Applic. Date: 2006-05-24; US20090147041P Applic. Date: 2009-01-23; US20090147032P Applic. Date: 2009-01-23; US20090144422P Applic. Date: 2009-01-13; US20090144147P Applic. Date: 2009-01-12; US20090144144P Applic. Date: 2009-01-12; US20050683847P Applic. Date: 2005-05-24; US20050730335P Applic. Date: 2005-10-26; US20060802670P Applic. Date: 2006-05-23

Inventor: REID TED [US]; SPALLHOLZ JULIAN [US]; DEVANATHAN THIRUMAL N [US]; MOSLEY THOMAS [US]


Application No.: US20100028829A1  Published: 04/Feb/2010

Title: CHEMICALLY ACTIVATED DENTAL BLEACHING TRAYS

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/183303   Filing Date: 31/Jul/2008

Abstract:Dental treatment trays and strips used to deliver a dental bleaching composition to a person's teeth are formed from a moisture resistant barrier material and include a bleaching agent destabilizer disposed on an inner treatment surface of the barrier layer that is positioned against the person's teeth during use. The bleaching agent destabilizer may be compounded with the moisture resistant material or otherwise disposed relative to the barrier layer so that at least some destabilizer is positioned on the inner treatment surface of the tray or strip so as to contact the dental bleaching composition during use.

Priority:

Inventor: LEWIS PAUL E [US]; ANDERSEN SCOT N [US]; ALLRED PETER M [US]; FISCHER DAN E [US]


Application No.: US20100028831A1  Published: 04/Feb/2010

Title: Dispensing syringe having multiple barrels for discharging a dental composition

Applicant/Assignee:

Application No.: 12/587417   Filing Date: 07/Oct/2009

Abstract:A dispensing syringe for dispensing a multi-component dental composition, preferably a two component composition, is provided. The syringe includes a syringe body with multiple elongated barrels for storing the components of the composition

a threaded plunger rod assembly

and a rotatable, threaded connector knob. Preferably, the syringe body has a double-barrel structure and the plunger rod assembly includes two plunger rods that slide within the barrels. The threaded knob has a through-bore with a continuous internal thread for engaging the outer threads of the first and second plunger rods. A dental practitioner manually rotates the knob to displace the first and second plunger rods and discharge the components. The dispensing syringe may further include a dispensing tip containing a static mixing element for mixing the components and dispensing the mixed composition.

Priority: US2005-238374 Applic. Date: 2005-09-29

Inventor: PIERSON PAUL R [US]


Application No.: US20100028832A1  Published: 04/Feb/2010

Title: Dental device for use in the obturation of a root canal

Applicant/Assignee:

Application No.: 12/587347   Filing Date: 06/Oct/2009

Abstract:Kit-of-parts containing (i) a dental device for use in the obturation of a root canal which comprises a tapered obturating point portion integrally connected at the distal end of a functional portion, whereby the functional portion comprises (a) a neck portion adjacent to the obturating point portion, and (b) a handle portion, and (ii) a dental sealant composition, wherein the dental device is made of a material obtainable by curing a composition containing one or more curable components contained in the dental sealant.

Priority: WO2006EP00963 Applic. Date: 2006-02-03; US2007-890411 Applic. Date: 2007-08-06; EP20050002423 Applic. Date: 2005-02-04; EP20060706627 Applic. Date: 2006-02-03

Inventor: GUTZNER ANDREAS E [DE]; KLEE JOACHIM E [DE]


Application No.: US20100029547A1  Published: 04/Feb/2010

Title: Mvl, an antiviral protein from a cyanobacterium

Applicant/Assignee: THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Application No.: 10/592422   Filing Date: 09/Mar/2005

Abstract:The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1->6)Man-beta (1->4) GlcNAc-beta(1->4)GlcNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.

Priority: US20040551058P Applic. Date: 2004-03-09; WO2005US07703 Applic. Date: 2005-03-09

Inventor: BEWLEY CAROLE A [US]


Application No.: US20100029617A1  Published: 04/Feb/2010

Title: 1,4,5,6,7,8-HEXAHYDRO-1,2,5-TRIAZA-AZULENE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

Applicant/Assignee: ACTELION PHARMACEUTICALS LTD

Application No.: 12/439303   Filing Date: 27/Aug/2007

Abstract:The invention relates to 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives and their use as orexin receptor antagonists.

Priority: WO2006IB52984 Applic. Date: 2006-08-28; WO2007IB53417 Applic. Date: 2007-08-27

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]


Application No.: US20100029657A1  Published: 04/Feb/2010

Title: Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof

Applicant/Assignee: WYETH

Application No.: 12/393565   Filing Date: 26/Feb/2009

Abstract:Compounds of formula A: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

Priority: US20080067843P Applic. Date: 2008-02-29; US20080116809P Applic. Date: 2008-11-21

Inventor: LEVIN JEREMY IAN [US]; HOPPER DARRIN WILLIAM [US]; TORRES NANCY [US]; DUTIA MINU DHANJISHA [US]; BERGER DAN MAARTEN [US]; WANG XIAOLUN [US]; DI GRANDI MARTIN JOSEPH [US]; ZHANG CHUNCHUN [US]; DUNNICK ALEJANDRO LEE [US]


Application No.: US20100029661A1  Published: 04/Feb/2010

Title: Anesthetic compositions and methods of use

Applicant/Assignee: ALPHA SYNERGY DEVELOPMENT, INC

Application No.: 12/460954   Filing Date: 27/Jul/2009

Abstract:The invention generally relates to anesthetic compositions comprising low doses of a selective a-2 adrenergic receptor agonists in combination with anesthetic agents. The invention also relates to methods of using these compositions

in particular, the use of these compositions in humans to enhance the efficacy of a local peripheral anesthetic injection. The compositions and the methods are particularly useful in regional block anesthetic injections, and more particularly, in dental anesthetic injections.

Priority: US20080137714P Applic. Date: 2008-08-01; US20080192777P Applic. Date: 2008-09-22; US20080203120P Applic. Date: 2008-12-18; US20090207481P Applic. Date: 2009-02-12

Inventor: HORN GERALD [US]


Application No.: US20100029711A1  Published: 04/Feb/2010

Title: NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEURO SEARCH A/S

Application No.: 12/520236   Filing Date: 18/Dec/2007

Abstract:This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20060001678 Applic. Date: 2006-12-20; US20060875806P Applic. Date: 2006-12-20; WO2007EP64130 Applic. Date: 2007-12-18

Inventor: PETER DAN [CH]; REDROBE JOHN PAUL [DK]; OLSEN GUNNAR M [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100030213A1  Published: 04/Feb/2010

Title: TUBULAR SHAFT INSTRUMENT

Applicant/Assignee:

Application No.: 12/444356   Filing Date: 26/Sep/2007

Abstract:The invention relates to tubular shaft instruments, which are provided with a handle, a tubular shaft and a tool head. The tool head usually has two mouth parts, which can be displaced in relation to one another for gripping and fixing tissue. The invention discloses a slotted guide system for forming the articulation, said system having a virtual fulcrum outside the tubular shaft instrument.

Priority: DE200610046919 Applic. Date: 2006-10-05; DE200610046920 Applic. Date: 2006-10-05; DE200610047204 Applic. Date: 2006-10-05; DE200610047215 Applic. Date: 2006-10-05; DE200610056405 Applic. Date: 2006-11-29; DE200610059175 Applic. Date: 2006-12-14; WO2007EP08386 Applic. Date: 2007-09-26

Inventor: HAFNER DIETER [DE]


Application No.: US20100031958A1  Published: 11/Feb/2010

Title: RESPIRATORY MASK INTERFACE

Applicant/Assignee:

Application No.: 12/535823   Filing Date: 05/Aug/2009

Abstract:An interface for a respiratory mask includes a first flexible member and a second flexible member. The first flexible member is configured to be accommodated on a user's face. The first flexible member circumscribes one or more portions of the user's face. The second flexible member is configured complimentary to the first flexible member to circumscribe the one or more portions of the user's face. Further, the second flexible member is attached with the first flexible member to configure at least one hollow enclosure therebetween. In an embodiment, a hollow enclosure of the at least one hollow enclosure is filled with a cooling gel for cooling the user's face. The second flexible member is configured to accommodate the respiratory mask thereon.

Priority: US20080137927P Applic. Date: 2008-08-05

Inventor: STEWART RUTH [CA]


Application No.: US20100032353A1  Published: 11/Feb/2010

Title: LIQUID DISPENSER OR WATER PURIFICATION UNIT WITH ANTIMICROBIAL MOUTHPIECE OR HOUSING

Applicant/Assignee:

Application No.: 12/448075   Filing Date: 06/Dec/2007

Abstract:Liquid dispenser or water purification unit with a housing and a mouthpiece configured for contact with the mouth of a person, wherein at least part of the housing or part of the mouthpiece or parts of both have an antimicrobial surface.

Priority: WO2007DK00532 Applic. Date: 2007-12-06; US20060873440P Applic. Date: 2006-12-07

Inventor: FRANDSEN MIKKEL VESTERGAARD [CH]


Application No.: US20100032358A1  Published: 11/Feb/2010

Title: MODULAR WATER PURIFICATION UNIT

Applicant/Assignee:

Application No.: 12/448078   Filing Date: 06/Dec/2007

Abstract:A portable water purification unit in the form of a stiff, tubular housing with a first opening at a first end for entrance of water into the tubular housing and a mouthpiece at an opposite end. The tubular housing comprises at least a first module and a connected second tubular module containing mutually different water purifying granular resins. The first module or the second module have at least one water permeable mesh with a mesh size smaller than the grain size of the resins for preventing mixing of the resins.

Priority: WO2007DK00531 Applic. Date: 2007-12-06; US20060873441P Applic. Date: 2006-12-07

Inventor: VESTERGAARD FRANDSEN MIKKEL [CH]


Application No.: US20100032401A1  Published: 11/Feb/2010

Title: PROCEDURE FOR MANUFACTURING BOTTLES CONTAINING FLUIDS, PARTICULARLY COSMETIC, MEDICAL, PHARMACEUTICAL PRODUCTS OR THE LIKE, AND RELATIVE SYSTEM AND BOTTLES

Applicant/Assignee:

Application No.: 12/450352   Filing Date: 18/Mar/2008

Abstract:The procedure for manufacturing bottles (2) containing fluids, particularly-cosmetic, medical, pharmaceutical products or the like, comprises a forming phase of a hollow body (4) having a dispensing mouth (5) that can be closed by means of removable closing means (8) comprising shutter means (10) that can be coupled with the mouth, the closing means being made in a single body with the hollow body. During the forming phase, the closing means are arranged with the shutter means substantially transversal to the direction of coupling with the dispensing mouth. After the forming phase a coupling" phase is contemplated of the shutter means with the dispensing mouth.

Priority: IT2007MO00104 Applic. Date: 2007-03-23; WO2008IB00647 Applic. Date: 2008-03-18

Inventor: FONTANA ANTONIO [IT]


Application No.: US20100033892A1  Published: 11/Feb/2010

Title: COMPACT GAS LIGHTING DEVICE FOR AN ELECTRIC HOUSEHOLD APPLIANCE, IN PARTICULAR A COOKING DEVICE

Applicant/Assignee: ITW INDUSTRIAL COMPONENTS S.R.L. CON UNICO SOCIO

Application No.: 12/529329   Filing Date: 25/Mar/2008

Abstract:A gas lighting device including: a body formed by an electrically insulating material and carrying a plurality of high-voltage outputs for the connection to spark generating means

a transformer accommodated in the body and including a primary winding wound about and carried by a ferromagnetic material core, a carrying element formed by an electrically insulating material and designed to contain within a tubular drum thereof the primary winding, and a secondary winding consisting of a plurality of coils externally carried by the drum of the carrying element, electrically insulated from the primary winding and essentially coaxial with the latter

the core is bar-shaped and accommodated inside the carrying element and the drum directly supports also the high-voltage outputs, which are integrally obtained on the drum so as to form therewith the carrying element and laterally overhangingly protrude from the drum.

Priority: IT2007TO00215 Applic. Date: 2007-03-26; WO2008IB00702 Applic. Date: 2008-03-25

Inventor: PIANEZZE DANIELE [IT]; ALEARDI MASSIMO [IT]


Application No.: US20100034747A1  Published: 11/Feb/2010

Title: Detection of HIV-1 Infection

Applicant/Assignee:

Application No.: 11/922404   Filing Date: 15/Jun/2006

Abstract:This invention provides methods for to the use of the difference in phosphodiester (PDE)/phosphomonoester (PME) ratio in biological fluids, as an analytical criterion to image both the presence and degree of viral infection in-vivo.

Priority: US20050690489P Applic. Date: 2005-06-15; US20050690491P Applic. Date: 2005-06-15; WO2006US23346 Applic. Date: 2006-06-15

Inventor: ROZMYSLOWICZ TOMASZ [US]; WROBLEWSKI KRZYSZTOF [US]; GAULTON GLEN N [US]


Application No.: US20100034750A1  Published: 11/Feb/2010

Title: COMPOSITION AND METHOD FOR DETECTION OF DEMINERALISATION

Applicant/Assignee:

Application No.: 12/520128   Filing Date: 21/Dec/2007

Abstract:The invention relates to a composition for the detection of tooth demineralisation. More specifically, the invention concerns a composition comprising a complex capable of producing an optical signal characteristic of the presence of free ions, the pharmaceutical uses of such a composition, and methods and a kit for the detection of active demineralisation at tooth surfaces using such a composition.

Priority: GB20060025678 Applic. Date: 2006-12-21; WO2007GB04944 Applic. Date: 2007-12-21

Inventor: PERFECT EMMA [GB]; LONGBOTTOM CHRIS [GB]


Application No.: US20100034753A1  Published: 11/Feb/2010

Title: EDIBLE FOAM PRODUCT FOR THE TREATMENT OR PREVENTION OF OBESITY

Applicant/Assignee:

Application No.: 12/445478   Filing Date: 01/Oct/2007

Abstract:The present invention relates to an edible foam product that can advantageously be used in the treatment or prevention of obesity. More particularly, the present invention provides an edible foam product of pourable or spoonable consistency having an overrun of at least 100%, said foam product containing at least 60 wt. % of water, from 1 to 7 wt. % of protein and from 1 to 20 wt. % of carbohydrates, and further being characterised by a high in-mouth stability as evidenced by a reduction in overrun of less than 35% under in-mouth shear conditions and a high gastric stability as evidenced by a t 1/2 >30 minutes, t 1/2 representing the time needed to achieve a reduction in overrun of 50% under gastric conditions. Another aspect of the invention relates to the use of an edible foam product in the treatment or prevention of overweight or obesity, said edible foam product having a pourable or spoonable consistency, an overrun of at least 100% and a high gastric stability as evidenced by t 1/2 >30 minutes. Yet another aspect of the invention concerns a pressurised container holding an edible liquid composition and a propellant, which liquid composition can be released from the container by activating a valve to produce an edible foam product having a pourable or spoonable consistency, an overrun of at least 100% and a high gastric stability as evidenced by t 1/2 >30 minutes.

Priority: EP20060122405 Applic. Date: 2006-10-17; WO2007EP60354 Applic. Date: 2007-10-01

Inventor: COX ANDREW RICHARD [GB]; DE GROOT PETRUS WILHELMUS N [NL]; MELNIKOV SERGEY MICHAILOVICH [NL]; STOYANOV SIMEON DOBREV [NL]


Application No.: US20100034756A1  Published: 11/Feb/2010

Title: GRINDING METHOD FOR THE MANIPULATION OR PRESERVATION OF CALCIUM PHOSPHATE HYBRID PROPERTIES

Applicant/Assignee:

Application No.: 12/186940   Filing Date: 06/Aug/2008

Abstract:A solid state method of encouraging the physical interfacing of an organic component to a substantially crystalline inorganic component, including adding predetermined amounts of a substantially crystalline inorganic precursor and a predetermined amount of an organic precursor to yield an admixture, maintaining the admixture in a substantially liquid-free environment, and impacting the precursors together with sufficient energy to fuse the precursors into hybrid compounds. The so-formed hybrid compounds substantially retain the long range crystalline order characteristics of the substantially crystalline inorganic precursor.

Priority:

Inventor: KARLINSEY ROBERT L [US]


Application No.: US20100034761A1  Published: 11/Feb/2010

Title: PERSONAL CARE AND COSMETICS COMPOSITIONS COMPRISING BIOLOGICALLY-BASED MONO AND DI ESTERS

Applicant/Assignee:

Application No.: 12/579538   Filing Date: 15/Oct/2009

Abstract:Personal care compositions comprising esters of 1,3-propanediol and acceptable carriers are provided. The esters can have at least 3% biobased carbon, and the compositions can further comprise 1,3-propanediol that is biologically-derived. Also provided are processes for producing personal care compositions comprising esters of 1,3-propanediol and acceptable carriers. The processes comprise providing biologically produced 1,3-propanediol, contacting the 1,3-propanediol with organic acids, which produces the esters, recovering the esters, and incorporating the esters into personal care formulations. Also provided are processes of making a personal care composition comprising providing an ester of 1,3 propanediol and mixing the ester with an acceptable carrier to form a personal care composition.

Priority: US2007-705227 Applic. Date: 2007-02-12; US20060772471P Applic. Date: 2006-02-10; US20060772194P Applic. Date: 2006-02-10; US20060772193P Applic. Date: 2006-02-10; US20060772111P Applic. Date: 2006-02-10; US20060772120P Applic. Date: 2006-02-10; US20060772110P Applic. Date: 2006-02-10; US20060772112P Applic. Date: 2006-02-10; US20060846948P Applic. Date: 2006-09-25; US20060853920P Applic. Date: 2006-10-24; US20060859264P Applic. Date: 2006-11-15; US20060872705P Applic. Date: 2006-12-04; US20070880824P Applic. Date: 2007-01-17

Inventor: FENYVESI GYORGYI [US]; WEHNER ANN [US]; JOERGER MELISSA [US]; POLADI RAJA HARI PRASAD R [US]


Application No.: US20100034779A1  Published: 11/Feb/2010

Title: COMPOSITIONS AND METHODS FOR PRODUCING PLURIPOTENT CELLS FROM ADULT TESTIS

Applicant/Assignee:

Application No.: 12/092547   Filing Date: 02/Nov/2006

Abstract:The present application describes a method of producing embryonic stem cell (ESC)-like cells derived from adult mammalian testis. Furthermore, the application describes to a method of producing embryoid bodies from ESC-like cells as well as a method of producing a tissue and/or a differentiated cell from the ESC-like cell or the embryoid body. In addition, an ESC-like cell, an embryoid body and/or differentiated cell and/or tissue obtainable by said methods and pharmaceutical preparations containing the same are provided. Finally, the application describes to the use of these products for medical treatments and the preparation of pharmaceutical compositions for medical treatments.

Priority: US20050732132P Applic. Date: 2005-11-02; WO2006EP10529 Applic. Date: 2006-11-02

Inventor: GUAN KAOMEI [DE]; HASENFUSS GERD [DE]; NAYERNIA KARIM [DE]; ENGEL WOLFGANG [DE]


Application No.: US20100034810A1  Published: 11/Feb/2010

Title: PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION

Applicant/Assignee:

Application No.: 12/567051   Filing Date: 25/Sep/2009

Abstract:This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl

n is 0 to 5

m is 1 to 4

R1 is hydrogen

aryl

formyl

C1-6alkylcarbonyl

C1-6alkyl

C1-6alkyloxycarbonyl

substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy

substituted C1-6alkyloxyC1-6alkylcarbonyl

R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(-O)pR6, -NH-S(-O)pR6, -C(-O)R6, -NHC(-O)H, -C(-O)NHNH2, -NHC(-O)R6, -C(-NH)R6 or a 5-membered heterocycle

X1 is -NR5-, -NH-NH-, -N-N-, -O-, -C(-O)-, C1-4alkanediyl, -CHOH-, -S-, -S(-O)p-, -X2-C1-4alkanediyl- or -C1-4alkanediyl-X2-

R3 is NHR13

NR13R14

-C(-O)-NHR13

-C(-O)-NR13R14

-C(-O)-R15

-CH-N-NH-C(-O)-R16

substituted C1-6alkyl

optionally substituted C1-6alkyloxyC1-6alkyl

substituted C2-6alkenyl

substituted C2-6alkynyl

C1-6alkyl substituted with hydroxy and a second substituent

-C(-N-O-R8)-C1-4alkyl

R7

or -X3-R7

R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino

and pharmaceutical compositions comprising them.

Priority: WO2003EP01291 Applic. Date: 2003-02-07; US2004-544735 Applic. Date: 2004-02-04; WO2004EP01011 Applic. Date: 2004-02-04

Inventor: HEERES JAN [BE]; LEWI PAULUS JOANNES [BE]; JANSSEN PAUL ADRIAAN JAN [BE]; ARTS FRANK XAVIER JOZEF HERWIG [BE]; DE JONGE MARC RENE [NL]; KOYMANS LUCIEN MARIA HENRICUS [BE]; DAEYAERT FREDERIK FRANS DESIRE [BE]; VINKERS HENDRIK MAARTEN [BE]; GULLEMONT JEROME EMILE GEORGES [FR]; PASQUIER ELISABETH THERESA JEANNE [FR]


Application No.: US20100034818A1  Published: 11/Feb/2010

Title: Human Anti-NGF Neutralizing Antibodies as Selective NGF Pathway Inhibitors

Applicant/Assignee: AMGEN, INC MEDAREX, INC

Application No.: 12/576522   Filing Date: 09/Oct/2009

Abstract:This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

Priority: US2008-277919 Applic. Date: 2008-11-25; US2004-891658 Applic. Date: 2004-07-15; US2007-767326 Applic. Date: 2007-06-22; US20030487431P Applic. Date: 2003-07-15

Inventor: WILD JR KENNETH D [US]; TREANOR JAMES J S [US]; HUANG HAICHUN [US]; INOUE HEATHER [US]; ZHANG TIE J [US]; MARTIN FRANK [US]


Application No.: US20100034871A1  Published: 11/Feb/2010

Title: Center-Filled Chewing Gum Product For Dental Care

Applicant/Assignee:

Application No.: 12/573726   Filing Date: 05/Oct/2009

Abstract:A center-filled chewing gum product includes functional agents and a chewing gum substance enclosing a center-filling, wherein the center-filling includes toothpaste and the functional agents include at least one anti-plaque agent.

Priority: WO2007DK00175 Applic. Date: 2007-04-04

Inventor: MIKKELSEN RIKKE [DK]; PORSGAARD TANIA KJOELHEDE [DK]; BREINDAL BIRGITTE KRINGELUM [DK]


Application No.: US20100035201A1  Published: 11/Feb/2010

Title: Universal Template Enabling Drilling and Placing a Dental Implant Into A Patient's Jaw

Applicant/Assignee:

Application No.: 12/538206   Filing Date: 10/Aug/2009

Abstract:An apparatus for drilling into a patient's jaw, the apparatus comprising: a gel template

a cylinder embedded in the gel template

and a support arranged to fixate the gel template and the therein embedded cylinder in respect to the jaw, wherein the gel template comprises a gel selected to harden responsive of electromagnetic radiation, wherein the cylinder is arranged to allow drilling into the jaw, and wherein the cylinder is positioned within the gel template such as to enable drilling into the jaw through the cylinder.

Priority: US20080087707P Applic. Date: 2008-08-10

Inventor: BECK ISRAEL [IL]; BENYAMIN SHABTAY [IL]


Application No.: US20100035205A1  Published: 11/Feb/2010

Title: Non-90-Degree Ergonomically-Shaped Dental Prophylaxis Angle with a Straight Driving Shaft

Applicant/Assignee:

Application No.: 12/189152   Filing Date: 09/Aug/2008

Abstract:A disposable dental angle with a one-piece hollow housing, having the axis of its head section angled obtusely with respect to the axis of its tail section, is provided. The obtusely angled front aperture of the head section of the housing allows insertion of a driven rotor such that the driven rotor is positioned with an obtuse angle to the driving shaft in the end aperture of the tail section of the housing. The obtuse angle structure facilitates teeth cleaning operations by allowing the dental angle to easily reach all areas of the mouth and making practitioners feel more comfortable by allowing to maintain an ergonomically correct neutral wrist position and therefore reducing hand fatigue. A horseshoe-like snap retainer fits within the head section of the housing over the driven rotor to retain the rotor from coming out. A similar horseshoe-like snap retainer fits within the tail section of the housing over the driving shaft to retain the shaft firmly such that the gear of the driven rotor is always properly coupled to the matching gear of the driving shaft. The driving shaft transfers the rotation from a dental tool to the driven rotor for the purpose of tooth prophy using a cleaning cup.

Priority:

Inventor: WANG DANIEL [US]; SHEN JIANPING [US]; ZHU YONG [CN]


Application No.: US20100035213A1  Published: 11/Feb/2010

Title: Dental Kit and Method for Retracting Sulcus

Applicant/Assignee: COLTENE WHALEDENT AG

Application No.: 12/535979   Filing Date: 05/Aug/2009

Abstract:Sulcus is retracted from teeth prior to performing a dental procedure on the teeth by applying an expandable curable silicone compound to the surface of the teeth and preventing the silicone compound from expanding in a direction away from the surface of the teeth, thereby forcing the silicone to expand against the sulcus and forcing retraction of the sulcus from contact with the teeth.

Priority: EP20030006052 Applic. Date: 2003-03-19; US2006-546754 Applic. Date: 2006-10-10; WO2003CH00798 Applic. Date: 2003-12-02

Inventor: LUBBERS DIERK [CH]; LAMPL STEPHAN [CH]; KOLLEFRATH RALF [CH]


Application No.: US20100035215A1  Published: 11/Feb/2010

Title: Machinable Porcelain Compositions and Mill Blanks Thereof

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 12/552365   Filing Date: 02/Sep/2009

Abstract:A porcelain blank comprising a porcelain composition for dental restorations comprising a leucite crystallite phase and a glass matrix phase, wherein the leucite crystallites possess diameters not exceeding about 10 micron. Preferably, the porcelain composition has a maturing temperature from about 750 DEG C. to about 1050 DEG C. and a coefficient of thermal expansion from about 9x10-6/ DEG C. to about 17.5x10-6/ DEG C., and comprises: SiO2 57-67 Al2O3 7-15 K2O 7-15 Na2O 6-15 Li2O 0.5-3.

Priority: US1999-460951 Applic. Date: 1999-12-14; US1997-870965 Applic. Date: 1997-06-06; US1996-614044 Applic. Date: 1996-03-12

Inventor: BRODKIN DMITRI G [US]; PANZERA CARLINO [US]; KAISER LISA M [US]


Application No.: US20100035875A1  Published: 11/Feb/2010

Title: TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS

Applicant/Assignee:

Application No.: 12/488406   Filing Date: 19/Jun/2009

Abstract:A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Priority: US20080074510P Applic. Date: 2008-06-20

Inventor: ZHU BING-YAN [US]; SIU MICHAEL [US]; MAGNUSON STEVEN R [US]; PASTOR RICHARD [US]; HAIYING HE [CN]; YISONG XIAO [CN]; JIFU ZHENG [CN]; XING XU [CN]; JUNPING ZHAO [CN]; LIU WENDY [US]


Application No.: US20100035880A1  Published: 11/Feb/2010

Title: SUBSTITUTED SULFONYLAMINOARYLMETHYL CYCLOPROPANECARBOXAMIDE AS VR1 RECEPTOR ANTAGONISTS

Applicant/Assignee: PFIZER INC

Application No.: 12/578061   Filing Date: 13/Oct/2009

Abstract:This invention provides a compound of the formula (I): wherein A and B are independently CR12 or N

D and E are each independently CR9 or N

R1 represents (C1-C6)alkyl

R2 represents hydrogen, halogen, hydroxy, (C1-C6) alkyl, halo(C1-C6) alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy or (C1-C6)alkoxy-(C1-C6)alkyl

R3, R4, R5, R6, R10 and R11 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkyl or (C1-C6)alkoxy-(C1-C6)alkyl

or R3 and R4 are taken together with the carbon atom to which they are attached to form a 3- to 7-membered carbocyclic ring or heterocyclic ring in which one or two non-adjacent carbon atoms are optionally replaced by an oxygen atom, a sulfur atom or NH

R7 and R9 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, NH2, [(C1-C6)alkyl]NH-, [(C1-C6)alkyl]2N-, H2N-(C1-C6)alkoxy, (C1-C6)alkyl-NH-(C1-C6)alkoxy, [(C1-C6)alkyl]2N(C1-C6)alkoxy

H2N-(C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkyl-NH-(C1-C6)alkoxy-(C1-C6)alkyl, [(C1-C6)alkyl]2N(C1-C6)alkoxy-(C1-C6)alkyl or 5- or 6-membered heterocyclic ring containing at least one nitrogen atom

R8 represents halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C8)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, halo(C1-C6)alkylsulfonyl, halo(C1-C6)alkylsulfinyl, halo(C1-C6)alkoxy, halo(C1-C6)alkylthio, [(C1-C6)alkyl]NH- or [(C1-C6)alkyl]2N-

or R7 and R8, when E is CR9, are taken together with the carbon atoms to which they are attached form a 5-8 membered carbocyclic or heterocyclic ring, in which one or two non-adjacent carbon atoms are optionally replaced by oxygen, sulfur, N or NH groups, wherein the carbocyclic ring or the heterocyclic ring is unsubstituted or substituted with one or more substituents each independently selected from the group consisting of hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy and hydroxy(C1-C6)alkyl

and R12 represents hydrogen, halogen, (C1-C6)alkyl or hydroxy(C1-C6)alkyl

or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.

Priority: US2006-384127 Applic. Date: 2006-03-17; US20050733651P Applic. Date: 2005-11-04; US20050699800P Applic. Date: 2005-07-15; US20050663374P Applic. Date: 2005-03-17

Inventor: HANAZAWA TAKESHI [JP]; HIRANO MISATO [JP]; INOUE TADASHI [JP]; NAGAYAMA SATOSHI [JP]; NAKAO KAZUNARI [JP]; SHISHIDO YUJI [JP]; TANAKA HIROTAKA [JP]


Application No.: US20100036015A1  Published: 11/Feb/2010

Title: COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/517727   Filing Date: 18/Dec/2007

Abstract:The invention relates to a composition which is polymerizable by ring-opening metathesis polymerization (ROMP) comprising at least one monomer that is polymerizable by ROMP, at least one initiator of the Hoveyda-Grubbs type for initiating the ROMP and at least one retarder selected from the group consisting of heterocyclic a means having a ring with at least one N-atom and four or less other atoms constituting the ring bearing the at least one N-atom. The invention further relates to a process for the preparation of a composition which is polymerizable by ROMP, a dental material obtainable by polymerizing a composition according to the invention and the use of a substance selected from the group consisting of heterocyclic amines having a ring with at least one N-atom and five or less atoms constituting the ring bearing the at least one N-atom or of a mixture of two or more of such substances as a retarder in ROMP.

Priority: EP20060026426 Applic. Date: 2006-12-20; WO2007US87841 Applic. Date: 2007-12-18

Inventor: LUCHTERHANDT THOMAS [DE]; BISSINGER PETER [DE]; HANSEN MIRIAM [DE]


Application No.: US20100036075A1  Published: 11/Feb/2010

Title: POLYMERIZABLE MONOMER-CONTAINING COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523538   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups

and a polymerizable monomer (B) having one polymerizable group and at least one hydroxyl group. When a suitable component is added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50437 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; NISHIGAKI NAOKI [JP]


Application No.: US20100036280A1  Published: 11/Feb/2010

Title: METHOD OF UTILISING MEASUREMENTS OF THRESHOLD OF PAIN

Applicant/Assignee: ULL METER A/S

Application No.: 12/440438   Filing Date: 10/Sep/2007

Abstract:A method of determining the sympathetic tone and/or level of stress and/or level or warning system sensitivity includes the steps of: measuring an applied stimulation at a threshold value of the stimulation in one or more sympathetic tone-neutral points and measuring an applied stimulation at the same threshold value in one or more sympathetic tone-dependent points. The invention further relates to a system for applying and measuring a stimulation, and the use of a system for applying and measuring a stimulation for determining the sympathetic tone including the steps of: measuring an applied stimulation at a threshold value of the stimulation at one or more sympathetic tone-neutral points and measuring an applied stimulation at the same threshold value of the stimulation at one or more sympathetic tone-dependent points.

Priority: DK20060001159 Applic. Date: 2006-09-08; DK20060001321 Applic. Date: 2006-10-11; DK20070000190 Applic. Date: 2007-02-02; EP20070109765 Applic. Date: 2007-06-06; US20060842984P Applic. Date: 2006-09-08; US20060829068P Applic. Date: 2006-10-11; US20070924986P Applic. Date: 2007-06-07; WO2007EP59471 Applic. Date: 2007-09-10

Inventor: BALLEGAARD SOREN [DK]; MAGNUSSON GISLI [DK]


Application No.: US20100038365A1  Published: 18/Feb/2010

Title: HOT-MELT COMPOSITION FOR METAL CAN AND METAL CAN UTILIZING THE SAME

Applicant/Assignee: TOYO SEIKAN KAISHA, LTD

Application No.: 12/438053   Filing Date: 20/Aug/2007

Abstract:A hot-melt composition comprising a thermoplastic elastomer, a tackifier, a wax and a polyolefin resin, the wax having a softening point (R & B system) of 140 to 160 DEG C. The hot-melt composition can be easily applied to the mouth-neck portion of a metal can and can be excellently produced. Even when placed under a high-temperature condition, the sealing material that is formed exhibits excellent heat resistance maintaining the sealing.

Priority: JP20060223843 Applic. Date: 2006-08-21; WO2007JP66499 Applic. Date: 2007-08-20

Inventor: ISHIDA KATSUHIKO [JP]; UMANO SETSUO [JP]; UCHIDA KENSAKU [JP]; ISHIGURO HIDEYUKI [JP]; TSURUMAKI SHINOBU [JP]


Application No.: US20100038385A1  Published: 18/Feb/2010

Title: DISPENSING DEVICE

Applicant/Assignee: SEAQUIST PERFECT DISPENSING GMBH

Application No.: 12/337399   Filing Date: 17/Dec/2008

Abstract:A dispensing device for a cosmetic product is proposed. The dispensing device has a valve with a female valve element. The valve element has at least one engagement section for the positive and/or locking fastening of a male valve adapter which can be inserted into the valve element after assembly of the valve. Moreover, at its sealing side, the valve element forms a wall section which is enlarged in its inner diameter in order to permit faster filling.

Priority: DE200810038673 Applic. Date: 2008-08-12

Inventor: JASPER BERNHARD [DE]


Application No.: US20100038807A1  Published: 18/Feb/2010

Title: Solid Free-Form Fabrication Methods For The Production Of Dental Restorations

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 12/607718   Filing Date: 28/Oct/2009

Abstract:Solid free form fabrication techniques can be utilized indirectly to manufacture substrates, dies, models, near-net shapes, shells, and wax-ups that are then used in the manufacture of dental articles. Digital light processing is the most preferred indirect method for the production of substrates. After the substrates are produced, various coating or deposition techniques such as gel casting, slip casting, slurry casting, pressure infiltration, dipping, colloidal spray deposition or electrophoretic deposition are used to manufacture the dental article.

Priority: US2004-874077 Applic. Date: 2004-06-22; US2001-053430 Applic. Date: 2001-10-22; US2001-946413 Applic. Date: 2001-09-05; US1999-350604 Applic. Date: 1999-07-09; US2001-027017 Applic. Date: 2001-12-18; US1999-376921 Applic. Date: 1999-08-18; US2004-857482 Applic. Date: 2004-05-28; US19980092432P Applic. Date: 1998-07-10; US19980097216P Applic. Date: 1998-08-20; US20030474166P Applic. Date: 2003-05-29

Inventor: BRODKIN DMITRI [US]; PANZERA CARLINO [US]; PRASAD ARUN [US]; DAY GRANT P [US]; BORENSTEIN STEFAN [CA]


Application No.: US20100040252A1  Published: 18/Feb/2010

Title: Headset With Stowable Boom

Applicant/Assignee: PLANTRONICS, INC

Application No.: 12/190546   Filing Date: 12/Aug/2008

Abstract:A headset comprises a headband for supporting the headset on a user's head, an earpiece including an audio driver and a microphone boom including a microphone. The microphone boom is rotatable when the headset is located on a user's head from an operative position in which the microphone boom is directed towards the user's mouth to a stowed position in which the microphone boom is at least partially received in a recess defined in the headset.

Priority:

Inventor: THOMPSON DALE E [US]; MISTRY MANOJ [US]; LEDINGHAM JOHN B [US]; KRAMER MATTHEW E [US]


Application No.: US20100040310A1  Published: 18/Feb/2010

Title: EVACUABLE CONTAINER AND EVACUATION STRIP THEREFOR

Applicant/Assignee:

Application No.: 12/190445   Filing Date: 12/Aug/2008

Abstract:An evacuable container comprises a first sidewall that defines an interior of the container and an opening. A flow channel chamber comprises first and second chamber walls. Flow channels are disposed on at least one of the first and second chamber walls. One of the first and second chamber walls is sealingly attached along an entire periphery thereof to the first sidewall. At least one interior aperture is disposed through the first or second chamber wall and is in fluid communication with the interior of the container. At least one exterior aperture is disposed through the first or second chamber wall and is in fluid communication with an exterior of the container. A check valve is disposed in fluid communication with the at least one exterior aperture and the flow channel chamber to allow resealable evacuation of the container through the flow channel chamber and the at least one interior aperture.

Priority:

Inventor: TURVEY ROBERT R [US]


Application No.: US20100040548A1  Published: 18/Feb/2010

Title: HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS

Applicant/Assignee:

Application No.: 12/482373   Filing Date: 10/Jun/2009

Abstract:The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Priority: WO2006IB54724 Applic. Date: 2006-12-10

Inventor: YU CHONGXI [US]


Application No.: US20100040562A1  Published: 18/Feb/2010

Title: NOVEL COMPOSITION

Applicant/Assignee:

Application No.: 12/517675   Filing Date: 06/Dec/2007

Abstract:A post-foaming dentifrice composition having a viscosity of at least 80,000 mPas comprising a combination of a first thickening agent which is xanthan gum, a second thickening agent which is carrageenan and/or a polyacrylic acid and a thickening silica, together with a post-foaming agent to expand the composition to a foam.

Priority: GB20060024578 Applic. Date: 2006-12-08; WO2007EP63480 Applic. Date: 2007-12-06

Inventor: FROST PETER [GB]; MALMSTROM HANNA MARIA [GB]; PENEGAR MARK [GB]; PLATTS ALEXANDER THOMAS [GB]


Application No.: US20100040565A1  Published: 18/Feb/2010

Title: ACTIVE DELIVERY SYSTEMS FORMULATIONS

Applicant/Assignee: CASTLE BEACH, LLC

Application No.: 12/540201   Filing Date: 12/Aug/2009

Abstract:The present invention relates to active delivery system formulations, and methods of making and using the same. Said formulations, when applied to a substrate surface, form a protective coating on the surface and permit constituent active agents to act on the surface and in the surrounding medium.

Priority: US20080104129P Applic. Date: 2008-10-09; US20080088155P Applic. Date: 2008-08-12

Inventor: HOMOLA ANDREW M [US]; PITTS R GARY [US]; DUNTON RONALD K [US]


Application No.: US20100040668A1  Published: 18/Feb/2010

Title: Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 12/522800   Filing Date: 11/Jan/2008

Abstract:The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith.

Priority: US2007-622927 Applic. Date: 2007-01-12; US20060758207P Applic. Date: 2006-01-12; WO2008US50940 Applic. Date: 2008-01-11

Inventor: RIMAN RICHARD E [US]; SEVER CHRISTINA [US]


Application No.: US20100040703A1  Published: 18/Feb/2010

Title: USE OF NITRIC OXIDE

Applicant/Assignee:

Application No.: 12/540335   Filing Date: 12/Aug/2009

Abstract:The present invention relates to uses, compositions, devices, and methods involving the utilisation of nitric oxide to hinder, impede, inhibit, or prevent transmission of infectious viral particles to host cells.

Priority: US20080088656P Applic. Date: 2008-08-13

Inventor: MILLER CHRIS [CA]; MURRAY BRUCE [CA]; REGEV-SHOSHANI GILLY [CA]


Application No.: US20100041554A1  Published: 18/Feb/2010

Title: CONTROL OF PATHOGENS IN PLANTS, AND AN EFFICIENT MEANS TO ADD NUTRIENTS AND MICRONUTRIENTS TO PLANTS

Applicant/Assignee:

Application No.: 12/193123   Filing Date: 18/Aug/2008

Abstract:This invention consists of a new and novel chemical composition and application method for the control of a number of different types of plant pathogens. A homogeneous aqueous solution is prepared consisting of one or more metallic compounds, a natural product adjuvant for acidifying and forming the complex ions of these metals, and a surfactant. This resulting solution is applied to all plant surfaces down to the soil line until obvious runoff. This application is repeated periodically to totally and completely halt and interrupt the plant pathogen's life cycle in 1-8 weeks during the growing season with more restricted application during the dormant period for prophylactic purposes. This new composition of matter and method of application also serves as a very efficient method to add nutrients and micronutrients to the plant, and to control animal and plant pathogens that reside on a plant host.

Priority:

Inventor: MUSUMECI MICHAEL RICHARD [US]


Application No.: US20100041726A1  Published: 18/Feb/2010

Title: INHIBITORS OF Akt ACTIVITY

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION

Application No.: 12/571828   Filing Date: 01/Oct/2009

Abstract:Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Priority: US2008-027454 Applic. Date: 2008-02-07; US20070888586P Applic. Date: 2007-02-07

Inventor: SEEFELD MARK A [US]; ROUSE MEAGAN B [US]; HEERDING DIRK A [US]


Application No.: US20100041786A1  Published: 18/Feb/2010

Title: SINGLE-PART, LIGHT-CURABLE, SELF-ADHERING DENTAL RESTORATIVE COMPOSITION AND METHOD OF USING THE SAME

Applicant/Assignee: KERR CORPORATION

Application No.: 12/190762   Filing Date: 13/Aug/2008

Abstract:A dental restorative composition comprising: (A) polymerizable monomer(s) having at least one phosphorus-containing acidic moiety and at least one ethylenically unsaturated group

(B) polymerizable monomer(s) having a molecular weight of 100-250, at least one hydroxyl group, and at least one ethylenically unsaturated group

(C) polymerizable monomer(s) having a molecular weight of 270-900, at least two ethylenically unsaturated groups and no acidic functional group

(D) photo-initiator(s)

and (E) filler(s) each having a mean particle size of more than 0.005 microns and less than 70 microns. The weight ratio of (A+B):(C) ranges from 30:70 to 90:10, the concentration of (A) is 10-50 wt. %, the concentration of (B) is 15-60 wt. %, and the composition has a shear bond strength of at least 10 MPa to both dentin and enamel. Also provided is a method for filling a dental cavity with the composition without first treating the dental cavity with an etchant, a primer and/or an adhesive.

Priority:

Inventor: QIAN XUEJUN [US]


Application No.: US20100043164A1  Published: 25/Feb/2010

Title: Disposable toothbrush

Applicant/Assignee:

Application No.: 12/484433   Filing Date: 15/Jun/2009

Abstract:A disposable toothbrush includes a handle member produced from a pre-selected biodegradable material. The handle member has a predetermined size and a predetermined shape. There are a predetermined number of rows of bristles attached to and extending above a top surface of the handle member closely adjacent one end thereof. Such bristles have a predetermined length. A pouch containing toothpaste is disposed beneath the rows of bristles such that the toothpaste will be in fluid communication with the bristles when the pouch is punctured and compressed.

Priority: US2008-228986 Applic. Date: 2008-08-19

Inventor: HOLOWECKY BOHDAN [US]


Application No.: US20100043788A1  Published: 25/Feb/2010

Title: DEVICES AND METHODS FOR MINIMIZING AND TREATING HIGH-ALTITUDE SICKNESS

Applicant/Assignee:

Application No.: 12/541144   Filing Date: 13/Aug/2009

Abstract:Various devices and methods for treating high-altitude sickness are disclosed herein. According to one embodiment, a handheld device delivers a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.

Priority: US20080090617P Applic. Date: 2008-08-21

Inventor: FINE DAVID H [US]; VASQUEZ GREGORY [US]; JOHNSON BRYAN [US]


Application No.: US20100043838A1  Published: 25/Feb/2010

Title: Method and Apparatus for Cleaning a Mouthguard

Applicant/Assignee:

Application No.: 12/514920   Filing Date: 14/Nov/2007

Abstract:A device for cleaning and storing a mouthguard, including two main chambers shaped for receiving and holding a mouthguard. One of the main chambers has a sealable lid for retaining disinfecting liquid and the other main chamber has vents to allow water to drain away, and to allow air flow for drying the mouthguard.

Priority: CA20062567905 Applic. Date: 2006-11-14; WO2007CA02012 Applic. Date: 2007-11-14

Inventor: FOGET STEVE [CA]; COGAN DONALD S [CA]


Application No.: US20100044267A1  Published: 25/Feb/2010

Title: COMPOSTABLE CONTAINER FOR STORING FLUIDS

Applicant/Assignee:

Application No.: 12/544150   Filing Date: 19/Aug/2009

Abstract:A fully compostable container is provided having an enclosed body with an opening through an interior surface and an exterior surface. The enclosed body having a plant fiber structural layer configured to biodegrade in ambient conditions into nontoxic residue and a fluid barrier layer formed on a first side of the structural layer to form the interior surface of the enclosed body, the fluid barrier layer configured to biodegrade in ambient conditions into nontoxic residue. The container is gradually biodegradable when exposed to a set of factors in a natural environment and has a shelf life of six months when stored under standard commercial conditions.

Priority: US20080090871P Applic. Date: 2008-08-21

Inventor: TOLIBAS-SPURLOCK CYNTHIA [US]; ALLRED-FORSMAN BAMBI [US]; AGNEW-VON MOOS DARLA [US]


Application No.: US20100044895A1  Published: 25/Feb/2010

Title: Method of forming a dental product

Applicant/Assignee:

Application No.: 12/454065   Filing Date: 12/May/2009

Abstract:The invention provides a method of shaping a dental product, comprising: shaping a curable polymerizable composition to form a shape of a dental product. The polymerizable composition is adapted to cure to form polymeric material, which at 37 DEG C. has a flexural modulus of less than 250,000 psi and a flexural strength of less than 7,000 psi.

Priority: US2003-722830 Applic. Date: 2003-11-26

Inventor: SUN BENJAMIN J [US]; LICHKUS ANDREW M [US]


Application No.: US20100045705A1  Published: 25/Feb/2010

Title: Interaction techniques for flexible displays

Applicant/Assignee:

Application No.: 12/459973   Filing Date: 10/Jul/2009

Abstract:The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system. The invention also relates to interactive food or beverage container with associated computing apparatus inside its body, and a curved multitouch display on its surface, associated interaction techniques for curved multitouch displays, methods of use, and apparatus for refilling said electronic food or beverage container.

Priority: US2007-731447 Applic. Date: 2007-03-30; US20060788405P Applic. Date: 2006-03-30

Inventor: VERTEGAAL ROEL [CA]; LEE JUSTIN [CA]; BEHAR YVES [US]; PUTTORNGUL PICHAYA [US]


Application No.: US20100047190A1  Published: 25/Feb/2010

Title: USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI

Applicant/Assignee: BASF SE

Application No.: 12/519451   Filing Date: 18/Dec/2007

Abstract:The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment

and/or (ii) resistant to protease treatment

and/or (iii) calcium-dependent

and/or (iv) formed within a pH range between 4.5 and 8.5

and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase

(b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase

(c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci

and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.

Priority: EP20060026301 Applic. Date: 2006-12-19; WO2007EP11127 Applic. Date: 2007-12-18

Inventor: REINDL ANDREAS [DE]; LANG CHRISTINE [DE]; BOETTNER MEWES [DE]; VEEN MARKUS [DE]


Application No.: US20100047191A1  Published: 25/Feb/2010

Title: NOVEL USE

Applicant/Assignee:

Application No.: 12/594502   Filing Date: 03/Apr/2008

Abstract:The use of an oral care composition comprising particulate zinc oxide (suitably in nanoparticulate form) optionally in the presence of a source of fluoride ions is described for combating dental erosion and/or tooth wear. Such compositions are also of use in combating dental caries.

Priority: GB20070006787 Applic. Date: 2007-04-05; WO2008EP54045 Applic. Date: 2008-04-03

Inventor: FOWLER CHRISTABEL [GB]


Application No.: US20100047261A1  Published: 25/Feb/2010

Title: BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN

Applicant/Assignee: CUREVAC GMBH

Application No.: 12/446912   Filing Date: 31/Oct/2007

Abstract:The present application describes a base-modified RNA and the use thereof for increasing the expression of a protein and for the preparation of a pharmaceutical composition, especially a vaccine, for the treatment of tumours and cancer diseases, heart and circulatory diseases, infectious diseases, autoimmune diseases or monogenetic diseases, for example in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the base-modified RNA, and an in vivo method.

Priority: DE200610051516 Applic. Date: 2006-10-31; WO2007EP09469 Applic. Date: 2007-10-31

Inventor: HOERR INGMAR [DE]; MULBE FLORIAN VON DER [DE]


Application No.: US20100047297A1  Published: 25/Feb/2010

Title: NANOCRYSTALS FOR USE IN TOPICAL COSMETIC FORMULATIONS AND METHOD OF PRODUCTION THEREOF

Applicant/Assignee: ABBOTT GMBH & CO. KG

Application No.: 12/514621   Filing Date: 19/Nov/2007

Abstract:Provided are cosmetic preparations for topical application containing nanocrystals of cosmetic actives leading to an increased bioactivity of the molecules in the skin and methods of making the cosmetic preparations. The nanocrystals can be added to any cosmetic topical formulation, e. g. creams, lotions and liposomal dispersions. The drug nanocrystals are produced by a combination process of low energy pearl milling followed by a high energy high-pressure homogenization leading to nanocrystal suspensions (nanosuspensions) of improved physical stability.

Priority: US20060866233P Applic. Date: 2006-11-17; WO2007EP09943 Applic. Date: 2007-11-19

Inventor: PETERSEN ROLF [DE]


Application No.: US20100047438A1  Published: 25/Feb/2010

Title: UNIFORMLY COLOURED CERAMIC FRAMEWORK AND COLOURING SOLUTION

Applicant/Assignee: 3M ESPE AG (A WHOLLY-OWNED SUBSIDIARY OF 3M COMPANY)

Application No.: 12/610745   Filing Date: 02/Nov/2009

Abstract:The present invention relates to a colouring solution for ceramic framework, the ceramic framework coloured with the solution as well as a process to obtain a uniformly coloured ceramic framework. The solution comprises a solvent, a metal salt and polyethylene glycol having a Mn in the range of 1.000 to 200.000.

Priority: EP20030013513 Applic. Date: 2003-06-13; US2005-560702 Applic. Date: 2005-12-13; WO2004EP06220 Applic. Date: 2004-06-09

Inventor: HAUPTMANN HOLGER [DE]; BISSINGER PETER [DE]


Application No.: US20100047743B1  Published: 02/Feb/2010

Title: DENTAL RESTORATIONS USING NANOCRYSTALLINE MATERIALS AND METHODS OF MANUFACTURE

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 10/857482   Filing Date: 28/May/2004

Abstract:Dental articles are produced using relatively low sintering temperatures to achieve high density dental articles exhibiting strengths equal to and greater than about 700 MPa. Ceramic powders comprised of nanoparticulate crystallites are used to manufacture dental articles. The ceramic powders may include sintering agents, binders and other similar additives to aid in the processing of the ceramic powder into a dental article. The ceramic powders may be processed into dental articles using various methods including, but not limited to, injection molding, gel-casting, slip casting, or electroforming, hand, cad/camming and other various rapid prototyping methods. The ceramic powder may be formed into a suspension, pellet, feedstock material or a pre-sintered blank prior to forming into the dental article.

Priority: US20030474166P Applic. Date: 2003-05-29

Inventor: BRODKIN DMITRI [US]; GAMARNIK MOISEY Y [US]


Application No.: US20100048474A1  Published: 25/Feb/2010

Title: METHOD OF TREATING OR PREVENTING TISSUE DETERIORATION, INJURY OR DAMAGE DUE TO PERIODONTAL DISEASE OR DISEASE OF ORAL MUCOSA, AND/OR DOWNREGULATING NF-KAPPABETA OR SUPRESSING NF-KAPPABETA-MEDIATED ACTIONS

Applicant/Assignee: REGENERX BIOPHARMACEUTICAL, INC

Application No.: 12/444331   Filing Date: 05/Oct/2007

Abstract:A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (T[beta]4), an isoform of T[beta]4, an N-terminal fragment of T[beta]4, a C-terminal fragment of T[beta]4, T[beta]4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, T[beta]4ala, T[beta]9, T[beta]10, T[beta]11, T[beta]12, T[beta]13, T[beta]14, T[beta]15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, [beta]-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.

Priority: US20060849841P Applic. Date: 2006-10-06; US20060851992P Applic. Date: 2006-10-17; US20060859521P Applic. Date: 2006-11-17; US20070878701P Applic. Date: 2007-01-05; WO2007US21435 Applic. Date: 2007-10-05

Inventor: SOSNE GABRIEL [US]; WHEATER MICHELLE [US]; GOLDSTEIN ALLAN L [US]


Application No.: US20100048557A1  Published: 25/Feb/2010

Title: Triazolopyridine JAK Inhibitor Compounds and Methods

Applicant/Assignee:

Application No.: 12/488312   Filing Date: 19/Jun/2009

Abstract:A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Priority: US20080074506P Applic. Date: 2008-06-20

Inventor: ZHU BING-YAN [US]; SIU MICHAEL [US]; MAGNUSON STEVEN R [US]; PASTOR RICHARD [US]; HAIYING HE [CN]; YISONG XIAO [CN]; JIFU ZHENG [CN]; XING XU [CN]; JUNPING ZHAO [CN]


Application No.: US20100048589A1  Published: 25/Feb/2010

Title: Cold Menthol Receptor Antagonists

Applicant/Assignee:

Application No.: 12/539267   Filing Date: 11/Aug/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.

Priority: US20080089928P Applic. Date: 2008-08-19

Inventor: COLBURN RAYMOND W [US]; DAX SCOTT L [US]; FLORES CHRISTOPHER M [US]; LUDOVICI DONALD W [US]; MATTHEWS JAY M [US]; XIA MINGDE [US]; XU XIAOQING [US]; YOUNGMAN MARK A [US]; ZHU BIN [US]


Application No.: US20100048619A1  Published: 25/Feb/2010

Title: Cold Menthol Receptor Antagonists

Applicant/Assignee:

Application No.: 12/539277   Filing Date: 11/Aug/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4 and R5 are defined herein.

Priority: US20080089933P Applic. Date: 2008-08-19

Inventor: COLBURN RAYMOND W [US]; DAX SCOTT L [US]; FLORES CHRISTOPHER M [US]; LUDOVICI DONALD W [US]; XIA MINGDE [US]; XU XIAOQING [US]; YOUNGMAN MARK A [US]; ZHU BIN [US]


Application No.: US20100048761A1  Published: 25/Feb/2010

Title: POLYMERIZABLE MONOMER-CONTAINING COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523546   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups

and a water (B). The composition contains 6 to 2000 parts by weight of the water (B) with respect to 100 parts by weight of the whole amount of polymerizable monomer components. When suitable components are added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50436 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]


Application No.: US20100048762A1  Published: 25/Feb/2010

Title: COMPOSITION AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523591   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition that exhibits excellent adhesive properties to tooth structure (particularly dentin) when applied as a dental material. The present invention is a composition containing a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups, and a bisacylphosphine oxide (B) represented by the following formula (1): where the respective symbols are as defined in the specification.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50439 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; NISHIGAKI NAOKI [JP]; HINAMOTO AI [JP]; SUGIURA MARIKO [JP]


Application No.: US20100049661A1  Published: 25/Feb/2010

Title: TRACEABILITY PROCESS AND SECURITY ELEMENTS USED IN SAID PROCESS

Applicant/Assignee:

Application No.: 12/312210   Filing Date: 30/Aug/2007

Abstract:Bi-directional cattle traceability process comprising five basic stages: a first document traceability and sanitary certification chain stage, wherein the animals are identified by birth certificates, animal identification attached to the animal's ear and registered in a data centre. A second stage for transfer of animals to another establishment, wherein genetic material is extracted from the offspring not yet weaned, filed and registered and registered in the data centre. A third stage for slaughtering of animals, wherein the slaughtered animal's ear is cut off where the animal identification is attached and the animal identification is read on line, the half carcases have sealed strips applied to them, DNA samples are extracted from the animal, then deposited in the official genetic bank and on each cut a locket sampler is attached encrypting a genetic and biochemical sample. A fourth stage for transfer or exporting of cuts, wherein the barcode that originated the cut is identified and applied to each portion of this cut or piece into which it is divided and then the locket sampler is removed from each sliced or minced cut, to deposit it in the cold storage chamber. A fifth and last stage of traceability auditing, wherein three samples of the identified portion of a cut to de audited are taken and adulteration of the cut or non-adulteration is determined by comparing the genetic sample taken in the third stage with the encrypted genetic sample in the locket sampler that held the original cutting extracted in the fourth stage. Alternative traceability processes addressed to fishing and canning and a set of elements used in the different stages of the three processes are also disclosed.

Priority: AR2006P104750 Applic. Date: 2006-10-30; WO2007BR00297 Applic. Date: 2007-08-30

Inventor: LIMA ALBERTO JULIO MINORINI [AR]


Application No.: US20100050373A1  Published: 04/Mar/2010

Title: Suction nozzle for a vacuum cleaner

Applicant/Assignee:

Application No.: 12/231643   Filing Date: 04/Sep/2008

Abstract:A suction nozzle for a vacuum cleaner has a housing, a vacuum mouth disposed on the floor side in the housing, a cleaning roller mounted to rotate in the housing and driven by an electric motor, and a rechargeable battery unit for the energy supply of the electric motor. Via a rear connecting piece, the suction nozzle can be connected to a suction tube or a suction hose of a vacuum cleaner. The electric motor has a rated power of between 50 and watts, and the rechargeable battery unit has an energy density, relative to its total volume, of more than 200 watt-hours per liter (Wh/L).

Priority:

Inventor: KAFFENBERGER DIETER [DE]; DILGER HORST [DE]; RIEHL KLAUS-DIETER [DE]


Application No.: US20100050678A1  Published: 04/Mar/2010

Title: AIR CONDITIONER

Applicant/Assignee:

Application No.: 12/529278   Filing Date: 20/Feb/2008

Abstract:A centrifugal fan mounted in an air conditioner has the following relationship: outer diameter of a side plate of the centrifugal fan>outer diameter of the blade rear-edge part on side-plate side>diameter of the blade rear-edge part on main plate side>outer diameter of the main plate. In the centrifugal fan, the blade rear-edge part is positioned inside from a straight line connecting the connection point between the blade rear-edge part and the main plate, to the connection point between the blade rear-edge part and the side plate, as viewed from the rotation axis. The blade rear-edge part has a shape such that the distance from the rotation axis becomes larger from the main plate toward the side plate.

Priority: JP20070065337 Applic. Date: 2007-03-14; WO2008JP52797 Applic. Date: 2008-02-20

Inventor: IKEDA TAKASHI [JP]; TAKAHARA NAHO [JP]; TSUTSUMI HIROSHI [JP]; YAMATANI TAKAHIRO [JP]; NISHIMIYA KAZUNOBU [JP]; KAWANORI YUKIHIKO [JP]


Application No.: US20100051050A1  Published: 04/Mar/2010

Title: Toothbrush combined with rinsing cup

Applicant/Assignee:

Application No.: 12/202202   Filing Date: 29/Aug/2008

Abstract:The technology described herein provides a combined toothbrush and rinsing cup. A combined toothbrush and rinsing cup includes a head, a plurality of bristles disposed upon the head, a body integrally connected to the head, a connectivity base integrally connected to the body, and a male connector integrally connected to the connectivity base. Additionally, a combined toothbrush and rinsing cup includes a toothbrush handle connected to the toothbrush, the toothbrush handle that includes a connector end, a female connector disposed within the connector end of the toothbrush handle and configured for sealable attachment to the male connector of the toothbrush, and a hollow cavity disposed within the toothbrush handle and configured for use as a rinsing cup. The toothbrush is removably connected to the toothbrush handle and wherein the toothbrush is configured for inversion and subsequent storage within the toothbrush handle.

Priority:

Inventor: DJANG SAM S [US]


Application No.: US20100055051A1  Published: 04/Mar/2010

Title: MALODOUR COUNTERACTING COMPOSITION

Applicant/Assignee:

Application No.: 12/517188   Filing Date: 07/Dec/2007

Abstract:A composition for counteracting malodour due to thiols, with the composition including a polyphenol, a source of polyphenol, a composition comprising polyphenol or mixtures thereof, a base, and optionally, an enzyme, wherein the polyphenol is encapsulated. The polyhenol is preferably a green tea extract and the enzyme is polyphenol (per)oxidase acetone powder.

Priority: US20060871259P Applic. Date: 2006-12-21; WO2007IB54963 Applic. Date: 2007-12-07

Inventor: DOUGHERTY KENNETH PAUL [US]; PIKA JANA [US]; ZENG QIAOLING CHARLENE [US]


Application No.: US20100055053A1  Published: 04/Mar/2010

Title: COMBINATIONS FOR ORAL COMPOSITIONS, THEIR PREPARATION AND USE

Applicant/Assignee: ORALDENT LIMITIED

Application No.: 12/374443   Filing Date: 20/Jul/2007

Abstract:A composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof

(b) sodium hyaluronate

and (c) water

and, optionally, (d) a pharmaceutically acceptable carrier therefor

wherein the sodium hyaluronate has an average molecular weight of between 800,000 and 4,000,000.

Priority: GB20060014353 Applic. Date: 2006-07-20; WO2007GB02756 Applic. Date: 2007-07-20

Inventor: RIPLEY IAN [GB]; THOMAS HOWARD [GB]


Application No.: US20100055161A1  Published: 04/Mar/2010

Title: HYDROGEL FACE MASK FOR DELIVERING SKIN CARE AGENTS

Applicant/Assignee:

Application No.: 12/199751   Filing Date: 27/Aug/2008

Abstract:Skin care can be provided by the skin care devices and compositions described herein. Such a skin care device can be configured to include a biocompatible hydrogel layer including one or more treatment agents, and an associated backing layer associated with the hydrogel layer.

Priority:

Inventor: AHN DONG JUNE [KR]


Application No.: US20100055639A1  Published: 04/Mar/2010

Title: DENTAL TREATMENT TRAYS COMPRISING SILICONE OR OTHER ELASTOMERIC MATERIAL

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/201902   Filing Date: 29/Aug/2008

Abstract:Non-customized dental treatment trays used to provide a desired treatment are formed from elastomeric silicone or silicone-like material. They may be injection molded from a two-part liquid silicone composition or a silicone-like TPE material (e.g., preferably SEBS and/or VERSAflex thermoplastic elastomer). The dental treatment trays possess high adaptability, flexibility, softness, and elastic elongation while also exhibiting resiliency in order to readily conform to the ridges, depressions and contours of a person's teeth during use. The trays possess a greater ability to adhere to a person's teeth compared to non-elastomeric thermoplastic materials. Due to their high adaptability and conformability, the non-customized dental trays behave like a semi-custom dental tray when placed over conformed to a person's teeth, particularly when used in combination with a sticky, viscous treatment composition.

Priority:

Inventor: LEWIS PAUL [US]; ANDERSEN SCOT N [US]; ALLRED PETER M [US]; FISCHER DAN E [US]


Application No.: US20100056562A1  Published: 04/Mar/2010

Title: CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/615925   Filing Date: 10/Nov/2009

Abstract:This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20040001491 Applic. Date: 2004-09-30; US2007-661966 Applic. Date: 2007-03-06; WO2005EP54861 Applic. Date: 2005-09-28; US20040614052P Applic. Date: 2004-09-30

Inventor: PETERS DAN [SE]; OLSEN GUNNAR M [DK]; SCHEEL-KRUGER JORGEN [DK]; NIELSEN ELSEBET OSTERGAARD [DK]


Application No.: US20100056628A1  Published: 04/Mar/2010

Title: Preservative compositions

Applicant/Assignee:

Application No.: 12/589155   Filing Date: 19/Oct/2009

Abstract:Green and naturally derived biocides such as N[alpha]-(C1-C22) alkanoyl di basic amino acid alkyl (C1 to C22) ester salt cationic molecules can be combined with an anionic molecule not generally considered as having significant biocidal activity to provide antimicrobial, antibacterial, and/or antifungal properties with multifunctional benefits including preservative or self-preserving activity.

Priority: US2006-517147 Applic. Date: 2006-09-07; US2006-633231 Applic. Date: 2006-12-04; US2009-585695 Applic. Date: 2009-09-22; US2009-583919 Applic. Date: 2009-08-27; US20080196455P Applic. Date: 2008-10-17

Inventor: STOCKEL RICHARD F [US]; SAWYER ANTHONY JOSEPH [US]


Application No.: US20100056636A1  Published: 04/Mar/2010

Title: N-Substituted-P-Menthane-3-Carboxamide and Uses Thereof

Applicant/Assignee:

Application No.: 12/519801   Filing Date: 30/Nov/2007

Abstract:The present invention relates to substances and compositions having a physiological cooling effect on the skin and the mucosa of the body, especially of the oral cavity, throat and nose. More in particular, the present invention relates to N-substituted-p-menthane-3-carboxamides represented by the following formula (I): and esters thereof. These substances are capable of imparting and/or enhancing a physiological cooling effect in a product in which they are incorporated, much more effectively than the heretofore known N-substituted-p-menthane-3-carboxamides.

Priority: EP20060126622 Applic. Date: 2006-12-20; US20070982464P Applic. Date: 2007-10-25; WO2007NL50609 Applic. Date: 2007-11-30

Inventor: FURRER STEFAN MICHAEL [US]; TONDEUR SANDER [NL]; WINKEL CHRIS [NL]; RENES HARRY [NL]; DE KLERK ADRI [NL]


Application No.: US20100056665A1  Published: 04/Mar/2010

Title: POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/532289   Filing Date: 06/Mar/2008

Abstract:The present invention provides a polymerizable composition that imparts excellent adhesive properties with respect to tooth structure (particularly dentin) when applied as a dental material, and provides a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a compound (A) that is a compound represented by the following formula (1): where G indicates a polymerizable group, m indicates an integer of 2 or more, n indicates an integer of 1 or more, and the sequence order of m units having a polymerizable group and n units having a hydroxyl group is arbitrary. The present invention also is a polymerizable composition containing the compound (A).

Priority: JP20070073603 Applic. Date: 2007-03-20; WO2008JP54087 Applic. Date: 2008-03-06

Inventor: SEKIGUCHI TAKAHIRO [JP]


Application No.: US20100057219A1  Published: 04/Mar/2010

Title: DEVICE SURFACE DESIGN FOR BETTER CELL ADHESION

Applicant/Assignee:

Application No.: 12/201855   Filing Date: 29/Aug/2008

Abstract:Embodiments herein relate to devices promoting cell adhesion and methods of making thereof In some embodiments, one or more insoluble or non-degradable second surface components are positioned over one or more soluble or degradable first surface components over a surface. The first surface components can be degraded or dissolved to produce bumps or raised portions formed from the second surface components on the surface.

Priority:

Inventor: LEE KWANGYEOL [KR]


Application No.: US20100058518A1  Published: 11/Mar/2010

Title: PORTABLE URINAL

Applicant/Assignee:

Application No.: 12/207547   Filing Date: 10/Sep/2008

Abstract:Embodiments provide portable apparatus adapted to accommodate a plurality of persons standing to engage in acts of urination, the portable apparatus including a movable base having a base outer edge, a movable base upper portion having a raised base central portion spaced in an inward direction from the base outer edge, a movable base upper portion including a plurality of spaced floor subsections intermediate a vertical riser and the base outer edge, the movable base upper portion including intermediate the plurality of spaced floor subsections a plurality of raised lower interior privacy partitions, each of said lower interior privacy partitions defining a secondary vertical riser, each of the raised lower interior privacy partitions adjoining a raised base central portion such that each secondary vertical riser cooperates with the vertical riser to define raised upper portions of a tank compartment, the tank compartment being defined by an interior space of the movable base.

Priority:

Inventor: BOURGEOIS BRYAN J [US]; BEARD GUY MICHAEL [US]


Application No.: US20100061942A1  Published: 11/Mar/2010

Title: Compositions and Methods for Modulating Store-Operated Calcium Entry

Applicant/Assignee:

Application No.: 12/279871   Filing Date: 20/Mar/2007

Abstract:Compositions and methods for modulating activity of store-operated calcium entry in cells or tissues are provided. The compositions comprise the P311 protein, fused to a cell-penetrating peptide and formulated for delivery to tissues and cells. This protein has been shown to increase the levels of store-operated calcium entry (SOCE) in gingival cells, skeletal muscle cells, and prostate epithelial cells. Also provided are methods for preventing and treating diseases that involve administration of the P311 fusion protein, as well as methods for increasing levels of SOCE in cells.

Priority: US20060783999P Applic. Date: 2006-03-20; WO2007US64365 Applic. Date: 2007-03-20

Inventor: MA JIANGIE [US]; WEISLEDER NOAH [US]; PAN ZUI [US]


Application No.: US20100061943A1  Published: 11/Mar/2010

Title: ORAL HEALTH COMPOSITION COMPRISING ALCHEMILLA VULGARIS

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/517342   Filing Date: 27/Nov/2007

Abstract:The present invention relates to Alchemilla vulgaris for use in oral health applications, an oral composition comprising Alchemilla vulgaris, and the use of Alchemilla vulgaris or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes Alchemilla vulgaris for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal

Priority: GB20060025429 Applic. Date: 2006-12-20; WO2007GB04522 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]


Application No.: US20100061944A1  Published: 11/Mar/2010

Title: ORAL HYGIENE COMPOSITION COMPRISING MYRTLE

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/516280   Filing Date: 27/Nov/2007

Abstract:The present invention relates to myrtle for use in oral health applications, an oral composition comprising myrtle, and the use of myrtle or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes myrtle for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal.

Priority: GB20060023619 Applic. Date: 2006-11-27; WO2007GB04532 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]


Application No.: US20100061971A1  Published: 11/Mar/2010

Title: Method for Treating Human Diseases Associated With an Increased Deoxyribonucleic Acid Content in Extracellular Spaces of Tissues and a Medicinal Preparation for Carrying Out Said Method

Applicant/Assignee:

Application No.: 12/516440   Filing Date: 28/Nov/2006

Abstract:The invention relates to medicine. The inventive method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs, consists in orally injecting a DNA ferment in a quantity of 20 000-500 000 Kunz units in a day per 1 kg of the body mass. The single dose of the inventive medicinal preparation for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs comprises 20 000-500 000 Kunz units of the DNAse ferment. The oral administration of the above-mentioned important doses of the preparation only allows the catalytically significant amount of DNAse to be absorbed into the systemic circulation in such a way that the dose-dependent treating effect thereof is exhibited.

Priority: WO2006RU00642 Applic. Date: 2006-11-28

Inventor: GENKIN DMITRY DMITRIEVICH [RU]; TETS VIKTOR VENIAMINOVICH [RU]; TETS GEORGY VIKTOROVICH [RU]


Application No.: US20100062030A1  Published: 11/Mar/2010

Title: USE OF DIACETYL DIMER AS AN AROMATIC AND/OR FLAVOURING SUBSTANCE

Applicant/Assignee: SYMRISE GMBH & CO., KG

Application No.: 12/300820   Filing Date: 07/May/2007

Abstract:The invention relates to the use of 5-acetyl-2,5-dimethyl-2-hydroxy-tetrahydrofuran-3-one (diacetyl dimer of formula (I)) in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two, three or four of its stereoisomers (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour

and/or (iii) as an aromatic and/or flavouring substance. The invention furthermore relates to a process (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour, to corresponding aromatic compositions, to formulations selected from a nutrition formulation (foodstuff), an oral hygiene formulation, a luxury product formulation, a formulation for oral pharmaceutical use or a semi-finished good formulation for the preparation of nutrition formulations or luxury product formulations, as well as preparations comprising one or more of said compositions and/or formulations.

Priority: US20060803715P Applic. Date: 2006-06-02; WO2007EP54401 Applic. Date: 2007-05-07

Inventor: LEY JAKOB [DE]; WEBER BERTHOLD [DE]; KRAMMER GERHARD [DE]; REISS INGO [DE]; BERTRAM HEINZ-JUERGEN [DE]; GALFIELD IAN [DE]; HOFFMANN-LUECKE PETRA [DE]


Application No.: US20100062052A1  Published: 11/Mar/2010

Title: PEPTIDE-BASED COMPOUNDS AS NEW INHIBITORS OF METALLOECTOPEPTIDASES, COMPOSITIONS COMPRISING SAID COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMETIC USES

Applicant/Assignee: GREENPHARMA

Application No.: 12/524955   Filing Date: 04/Feb/2008

Abstract:The invention relates to a compound that inhibits a metallo-ectopeptidase, selected in the group consisting of x-aa2-aa1-z, x-aa3-aa2-aa1-z, x-aa4-aa3-aa2-aa1-z and x-aa5-aa4-aa3-aa2-aa1-z, wherein: aa1 and aa4, independently from each other, represent an arginine amino acid, an histidine amino acid, an asparagine amino acid or a lysine amino acid, aa2 represents a serine amino acid, a glycine amino acid, a threonine amino acid or an alanine amino acid, aa3 represents a phenylalanine amino acid, a leucine amino acid, an isoleucine amino acid, a tyrosine amino acid or a tryptophan amino acid, aa5 represents a glutamine amino acid, a glutamic acid amino acid, an asparagines amino-acid or a lysine amino acid, x and z, independently from each other, represent: -H

-OH1 SH

-a halogen atom, -an amino group, -an alkyl, haloalkyl or heteroalkyl group containing from 1 to 30 carbon atoms, linear or branched, -an alkenyl or alkynyl group containing from 2 to 30 carbon atoms, linear or branched, -a cycloalkyl, cycloakenyl, cycloalkynyl or an heterocyclic group containing from 3 to 30 carbon atoms, linear or branched, -one or more aryl or heteroaryl groups containing from 3 to 10 carbon atoms per cycle, -a alkoxy, thioalkyl, sulfonylalkyl, aminoalkyl containing from 1 to 30 carbon atoms, linear or branched, -one or more heterocyclic group, containing from 5 to 10 carbon atoms per cycle, said groups being optionally substituted by one or more halogen atoms, alkyl groups, hydroxy groups, alkoxy groups, aryloxy groups, acyloxy groups, carbamoyloxy groups, carboxy groups, mercapto groups, alkylthio groups, acylthio groups, arylthio groups, aryl groups, heterocyclic groups, heteroaryl groups or amino groups.

Priority: US20070899033P Applic. Date: 2007-02-02; WO2008IB01328 Applic. Date: 2008-02-04

Inventor: BERNARD PHILIPPE [FR]


Application No.: US20100062086A1  Published: 11/Mar/2010

Title: Compositions and Methods of Their Use for Improving the Condition and Appearance of Skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 12/621027   Filing Date: 18/Nov/2009

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents, or synthetic equivalents thereof, which inhibit or decrease expression of C-reactive protein expression, production or secretion, thereby reducing, inhibiting, or ameliorating dermatological signs of aging. The compositions of the invention may be topically applied to the skin, or are delivered by directed means to a site in need thereof, in an amount effective in improving the condition and aesthetic appearance of skin.

Priority: US2006-647648 Applic. Date: 2006-12-29

Inventor: DRYER LAURENCE [US]; TAFURI SHERRIE R [US]; PTCHELINTSEV DMITRI S [US]


Application No.: US20100062394A1  Published: 11/Mar/2010

Title: PREFORMED MALLEABLE MULTILAYER DENTAL ARTICLES

Applicant/Assignee:

Application No.: 12/440615   Filing Date: 12/Sep/2007

Abstract:A dental article includes an external layer formed of a self-supporting hardenable preformed material having a dental article shape defined by an external layer surface. The external layer defines an interior volume. An interior material is disposed within the interior volume. The interior material is different than the external hardenable preformed material and the interior material has a yield stress value of 100 dyn/cm2 or greater.

Priority: US20060825496P Applic. Date: 2006-09-13; WO2007US78235 Applic. Date: 2007-09-12

Inventor: JONES TODD D [US]; KARIM NAIMUL [US]; JACOBS DWIGHT W [US]


Application No.: US20100062397A1  Published: 11/Mar/2010

Title: DENTAL CLEANING DEVICE

Applicant/Assignee: RYCA INTERNATIONAL, INC

Application No.: 12/555662   Filing Date: 08/Sep/2009

Abstract:Powered toothbrush systems that provide improved bristle positioning and bristle contact with tooth surfaces that reduce the time and effort required for effective brushing. Some embodiments use alternating or oscillating pneumatic pressure and suction to move a tooth brush head. Various configuration of the brush head provide different areas of coverage ranging from individual tooth to quarter mouth (U-cross section), to half (U-cross section or H-cross section) or whole mouth (U-cross section or H-cross section) coverage. Some embodiments include flexible fingers and/or bladders to keep the bristle tips properly engaged with the teeth and gums, providing bristle contact over a wide variety of malocclusion. The shape of the brush heads adapts to conform closely to the shape of the user's dental arch and to any malocclusion that may be present. The power toothbrush automatically generates motion of the brush head that simulates the "Modified Bass Method" of brushing.

Priority: US20080095219P Applic. Date: 2008-09-08

Inventor: BREWER GERALD K [US]


Application No.: US20100062399A1  Published: 11/Mar/2010

Title: DISPENSER TIP FILTER ASSEMBLY

Applicant/Assignee:

Application No.: 12/594606   Filing Date: 21/Apr/2008

Abstract:The invention features a dispenser tip filter assembly for dispensing fluid compositions, especially dental compositions, containing solid particles. The assembly includes a dispenser tip comprising a filter housing chamber and an exit orifice, and a filter unit positioned within the filter housing chamber in front of the exit orifice. The filter unit has one or more slots with a width less than the diameter of the exit orifice.

Priority: US20070913387P Applic. Date: 2007-04-23; WO2008US60990 Applic. Date: 2008-04-21

Inventor: CERNOHOUS ADAM J [US]


Application No.: US20100062441A1  Published: 11/Mar/2010

Title: C-MET MUTATIONS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/530172   Filing Date: 14/Mar/2008

Abstract:The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-Met.

Priority: US20070918254P Applic. Date: 2007-03-15; WO2008US57075 Applic. Date: 2008-03-14

Inventor: SALGIA RAVI [IL]


Application No.: US20100063021A1  Published: 15/May/2008

Title: Modulators of muscarinic receptors

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 11/894092   Filing Date: 20/Aug/2007

Abstract:The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Priority: US20060838701P Applic. Date: 2006-08-18

Inventor: DAVIES ROBERT J [US]; XU JINGWANG [US]


Application No.: US20100063149A1  Published: 11/Mar/2010

Title: FOOD COMPOSITION FOR BINDING ACETALDEHYDE IN MOUTH AND IN DIGESTIVE TRACK, AND METHOD FOR THE PREPARATION OF THE COMPOSITION

Applicant/Assignee: BIOHIT OYJ

Application No.: 12/622145   Filing Date: 19/Nov/2009

Abstract:The object of the invention comprises food compositions, to which one or more acetaldehyde-binding compounds are added. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas.

Priority: FI20050000341 Applic. Date: 2005-04-01; US2007-910458 Applic. Date: 2007-10-01; WO2006FI00104 Applic. Date: 2006-04-03

Inventor: SUOVANIEMI OSMO [FI]; SALASPURO MIKKO [FI]; SALASPURO VILLE [FI]; MARVOLA MARTTI [FI]


Application No.: US20100063187A1  Published: 11/Mar/2010

Title: COMPOSITIONS CONTAINING PHOSPHONATE-FUNCTIONAL PARTICLES

Applicant/Assignee: WACKER CHEMIE AG

Application No.: 12/513607   Filing Date: 22/Oct/2007

Abstract:Phosphonatoalkylsilyl-functional particles have high stability and resistance to agglomeration. When used in curable binder compositions, the particles contribute to a high level of scratch resistance.

Priority: DE200610053156 Applic. Date: 2006-11-10; WO2007EP61257 Applic. Date: 2007-10-22

Inventor: BRIEHN CHRISTOPH [DE]; BAUMANN MARTINA [DE]; JUNG-ROSSETTI SILVIA [DE]; STANJEK VOLKER [DE]


Application No.: US20100063473A1  Published: 11/Mar/2010

Title: DEVICE FOR THE ORAL APPLICATION OF A SUBSTANCE

Applicant/Assignee: SANDOZ AG

Application No.: 12/595739   Filing Date: 10/Apr/2008

Abstract:A device for oral application of a substance, comprising an inner tube surrounding a first volume an outer tube surrounding a second volume, the second volume comprising a cavity section adjoining an inlet opening of the outer tube being adapted for containing the substance, a separation area arranged in the second volume, the separation area adjoining the cavity section and the first volume, and a selective connecting passage between the cavity section and a pressure compensation space to selectively enable a flow of the substance from the cavity section though the first volume. A kit-of-parts, comprises the inventive device a predefined amount of a substance being contained in a receptacle or the cavity section, and instructions for the use of the substance. Methods for filling the inventive device as well as to a method for oral application using the inventive device are provided.

Priority: EP20070105845 Applic. Date: 2007-04-10; DE200710031368 Applic. Date: 2007-07-05; WO2008EP02820 Applic. Date: 2008-04-10

Inventor: SCHWARZ FRANZ XAVER [AT]; JAKOB THOMAS [DE]; REICHENBERGER ROBERT [DE]


Application No.: US20100064457A1  Published: 18/Mar/2010

Title: NOSE CLEANER, AND NOSE AND TOOTH CLEANER

Applicant/Assignee:

Application No.: 12/211222   Filing Date: 16/Sep/2008

Abstract:The invention relates to a nose cleaner in removing booger to make nasal vestibule clean, no matter a nose cleaner alone or a nose and tooth cleaner. A nose cleaner alone has a handle and a nose cleaning body. The nose cleaning body can be put into a nostril in removing booger to make nasal vestibule clean. On the other hand, a nose and tooth cleaner has a handle, a tooth cleaning body, and a nose cleaning body. It is convenient that besides of cleaning teeth with the tooth cleaning body, the nose cleaning body is availed to a user in putting into a nostril and removing booger to make nasal vestibule clean.

Priority:

Inventor: LEE CHUN YI [TW]


Application No.: US20100065075A1  Published: 18/Mar/2010

Title: Method for Preparing Fuel Element For Smoking Article

Applicant/Assignee: R.J. REYNOLDDS TOBACCO COMPANY

Application No.: 12/233192   Filing Date: 18/Sep/2008

Abstract:The invention provides a method for making a fuel element for a smoking article comprising forming a combustible carbonaceous material into a fuel element adapted for use in a smoking article

incorporating a metal-containing catalyst precursor into the fuel element or onto the surface thereof to form a treated fuel element, the incorporating step occurring before, during, or after said forming step

and optionally heating or irradiating the treated fuel element at a temperature and for a time sufficient to convert the catalyst precursor to a catalytic metal compound. Examples of metal-containing catalyst precursors include iron nitrate, copper nitrate, cerium nitrate, cerium ammonium nitrate, manganese nitrate, magnesium nitrate, and zinc nitrate. Fuel elements treated according to the invention, and smoking articles including such fuel elements, are also provided.

Priority:

Inventor: BANERJEE CHANDRA KUMAR [US]; SEARS STEPHEN BENSON [US]


Application No.: US20100065976A1  Published: 18/Mar/2010

Title: Methods of Making Orthodontic Appliances

Applicant/Assignee:

Application No.: 12/620826   Filing Date: 18/Nov/2009

Abstract:Methods of making a removable dental positioning appliance include forming a sheet of transparent crystalline polymeric material into a shell having cavities shaped to receive and reposition teeth from a first orientation to a successive orientation. The polymeric material may then be annealed at a temperature above its glass transition temperature or cured if a curable material to enhance characteristics of the polymeric material. The polymeric material may be coated with a second transparent material.

Priority: US2004-963252 Applic. Date: 2004-10-12

Inventor: DESIMONE JOSEPH M [US]; TRICCA ROBERT E [US]


Application No.: US20100068157A1  Published: 18/Mar/2010

Title: ORAL COMPOSITIONS, THEIR PREPARATION AND USE

Applicant/Assignee: ORAIDENT LIMITED

Application No.: 12/374447   Filing Date: 20/Jul/2007

Abstract:An oral composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the oral composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof

and (b) water

and, optionally, (c) a pharmaceutically acceptable carrier therefor.

Priority: GB20060014353 Applic. Date: 2006-07-20; WO2007GB02758 Applic. Date: 2007-07-20

Inventor: RIPLEY IAN [GB]


Application No.: US20100068158A1  Published: 18/Mar/2010

Title: Cleansing Composition

Applicant/Assignee:

Application No.: 12/158918   Filing Date: 29/Dec/2006

Abstract:The present invention relates to a cleansing composition comprising an anti-microbial agent and a sulphur binding and/or oxidising agent, and wherein the pH of the composition is 7 or lower, to a method for preparing the cleansing composition and its use.

Priority: EP20050078067 Applic. Date: 2005-12-30; WO2006EP12656 Applic. Date: 2006-12-29

Inventor: LAUGEMAN FRITS JAN RUDOLF [NL]


Application No.: US20100068159A1  Published: 18/Mar/2010

Title: FUNCTIONALIZED CALCIUM PHOSPHATE HYBRID SYSTEMS FOR CONFECTIONERY AND FOODSTUFF APPLICATIONS

Applicant/Assignee:

Application No.: 12/210137   Filing Date: 12/Sep/2008

Abstract:A method of whitening teeth, including an application of functionalized calcium phosphate additives generated via a solid-state method. The additives were produced by placing predetermined amounts of inorganic and inorganic materials and milling media into a vessel rotatably connected to a turntable platform, an amount of an organic material into the vessel, rotating the vessel in a first direction while turning the turntable platform in a second direction counter to the first direction, with the resultant material defining the functionalized calcium phosphate. The inorganic material may include calcium phosphates of varying phases, structure, and composition. The organic material may include anionic surfactants, cationic surfactants, neutral surfactants, carboxylic acids, polymers, copolymers, block copolymers, and combinations thereof. Once produced, the additives were added to comestibles, such as in confectionery and foodstuff formats, for delivery to the teeth and dental structures.

Priority:

Inventor: KARLINSEY ROBERT L [US]


Application No.: US20100068259A1  Published: 18/Mar/2010

Title: NATURAL PRODUCT INHIBITORS OF 3DG

Applicant/Assignee:

Application No.: 12/474904   Filing Date: 29/May/2009

Abstract:Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Priority: US20080057398P Applic. Date: 2008-05-30

Inventor: TOBIA ANNETTE [US]; ALICE MARCY [US]; SU BANGYING [US]; NIWA TAKESHI [JP]


Application No.: US20100068677A1  Published: 18/Mar/2010

Title: Novel Phosphorus-calcium-strontium compound and uses thereof in endodontic cements

Applicant/Assignee:

Application No.: 12/373225   Filing Date: 09/Jul/2007

Abstract:Phosphorus-calcium-strontium compound of formula (I)

method for preparing same

composition for the extemporaneous preparation of a cement comprising a solid phase (SP) and a liquid phase (LP), wherein the solid phase comprises a mixture of inorganic compounds of formula (II)

use as an endodontic cement.

Priority: FR20060006372 Applic. Date: 2006-07-12; WO2007FR01176 Applic. Date: 2007-07-09

Inventor: BOUDEVILLE PHILIPPE [US]


Application No.: US20100069340A1  Published: 18/Mar/2010

Title: PHARMACEUTICAL COMPOSITIONS OF AN SRC KINASE INHIBITOR AND AN AROMATASE INHIBITOR

Applicant/Assignee: WYETH

Application No.: 12/557668   Filing Date: 11/Sep/2009

Abstract:This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an aromatase inhibitor in treating abnormal cell proliferation and abnormal angiogenesis associated with cancer, including breast cancer.

Priority: US20080096155P Applic. Date: 2008-09-11; US20090166387P Applic. Date: 2009-04-03

Inventor: ZACHARCHUK CHARLES MICHAEL [US]; BOSCHELLI FRANK CHARLES [US]; GOLAS JENNIFER MICHELE [US]; ARNDT KIM TIMOTHY [US]


Application No.: US20100069357A1  Published: 18/Mar/2010

Title: PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee: GENENTECH, INC

Application No.: 12/533935   Filing Date: 31/Jul/2009

Abstract:Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).

Priority: US20080085309P Applic. Date: 2008-07-31

Inventor: BERGERON PHILIPPE [US]; COHEN FREDERICK [US]; ESTRADA ANTHONY [US]; KOEHLER MICHAEL F T [US]; LAU KEVIN HON LUEN [US]; LY CUONG [US]; LYSSIKATOS JOSEPH P [US]; ORTWINE DANIEL [US]; PEI ZHONGHUA [US]; ZHAO XIANRUI [US]


Application No.: US20100069525A1  Published: 18/Mar/2010

Title: HYDROPHILIC ORGANOPOLYSILOXANE COMPOSITION FOR USE AS DENTAL IMPRESSION MATERIAL

Applicant/Assignee: GC CORPORATION SHIN-ETSU CHEMICAL CO., LTD

Application No.: 12/251252   Filing Date: 14/Oct/2008

Abstract:A hydrophilic organopolysiloxane composition of the hydrosilylation reaction cure type for use as dental impression material is characterized by comprising as essential components (A) a diorganopolysiloxane having at least 0.1 silicon-bonded alkenyl group in a molecule, (B) a liquid or solid organopolysiloxane having average compositional formula (1), comprising SiO2 units and R3SiO1/2 units (R is a monovalent hydrocarbon, alkoxy or hydroxyl group) and having a viscosity of at least 10 mPas at 23 DEG C., (C) an organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in a molecule, (D) a hydrosilylation catalyst, and (E) a polyether having average compositional formula (2).

Priority: JP20080239551 Applic. Date: 2008-09-18

Inventor: KAMOHARA HIROSHI [JP]; OZAI TOSHIYUKI [JP]; SUGAHARA HIDEKI [JP]


Application No.: US20100069527A1  Published: 18/Mar/2010

Title: DENTAL SELF-ETCHING PRIMER COMPOSITION

Applicant/Assignee:

Application No.: 12/447874   Filing Date: 26/Oct/2007

Abstract:A dental self-etching primer composition and a dental self-etching primer kit comprising a mixture of (A) a polymerizable monomer, (B) a reducing inorganic compound containing sulfur, (C) a ketone-based solvent and (D) water and having a storage stability of 2 hours or longer at 65 DEG C.

Priority: JP20060294175 Applic. Date: 2006-10-30; WO2007JP71355 Applic. Date: 2007-10-26

Inventor: ARATA MASAMI [JP]; YAMAMOTO AKARI [JP]; KATSURA YOSHIAKI [JP]


Application No.: US20100071706A1  Published: 25/Mar/2010

Title: ANTIMICROBIAL DENTAL APPLIANCES INCLUDING MOUTHGUARDS AND MOUTHPIECES

Applicant/Assignee:

Application No.: 12/312632   Filing Date: 19/Nov/2007

Abstract:The present invention provides for a dental appliance, mouthguard and/or divers mouthpiece using an anti-microbial composition that combines the use of an elastomeric polymer composition with micronized or submicron sized particles of metal or organo/inorgano metal complexes. In addition, the use of an anti-microbial composition for use with a diver's air delivery hose to prevent breathing of contaminated air is also described.

Priority: US2006-601995 Applic. Date: 2006-11-20; WO2007US24188 Applic. Date: 2007-11-19

Inventor: MASON RICHARD [US]


Application No.: US20100071724A1  Published: 25/Mar/2010

Title: METHOD OF CLEANING BEVERAGE BOTTLES IN A BEVERAGE BOTTLING PLANT, A METHOD OF CLEANING CONTAINERS IN A CONTAINER FILLING PLANT, AND AN APPARATUS THEREFOR

Applicant/Assignee:

Application No.: 12/408266   Filing Date: 20/Mar/2009

Abstract:A method of cleaning beverage bottles in a beverage bottling plant, a method of cleaning containers in a container filling plant, and an apparatus therefor. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. PRG 1.72(b). As stated in 37 C.F.R. PRG 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading "Abstract of the Disclosure." The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Priority: DE200610044904 Applic. Date: 2006-09-22; WO2007EP07475 Applic. Date: 2007-08-25

Inventor: BAUMGARTNER KLAUS [DE]; KAPPEL STEFFEN [DE]; FAHLDIECK ANDREAS [DE]


Application No.: US20100074401A1  Published: 25/Mar/2010

Title: INTRAORAL X-RAY SYSTEM

Applicant/Assignee:

Application No.: 12/442163   Filing Date: 25/Sep/2007

Abstract:An improved intraoral x-ray system that includes a dental tray with the shape of a dental arch and can be positioned within the oral cavity, for accommodating image detectors at the lingual (or, palatal) side of the tray

an image processing system, situated external to said oral cavity, for converting the image data detected by the image detector to a viewable image

a mechanism for transferring the image data to the image processing system

and a display unit for displaying the image.

Priority: IL20060178393 Applic. Date: 2006-09-28; WO2007IL01195 Applic. Date: 2007-09-25

Inventor: KAYZERMAN BORIS [IL]


Application No.: US20100074876A1  Published: 25/Mar/2010

Title: CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS

Applicant/Assignee: WYETH ETEX CORPORATION

Application No.: 12/565159   Filing Date: 23/Sep/2009

Abstract:A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.

Priority: US2007-957691 Applic. Date: 2007-12-17; US2002-160607 Applic. Date: 2002-05-31; US20010296818P Applic. Date: 2001-06-08

Inventor: LI REBECCA [US]; SEEHERMAN HOWARD [US]; TOFIGHI ALIASSGHAR [US]


Application No.: US20100074959A1  Published: 25/Mar/2010

Title: LIPID GROWTH FACTOR FORMULATIONS

Applicant/Assignee: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH HEALTHPARTNERS RESEARCH FOUNDATION

Application No.: 12/446884   Filing Date: 23/Oct/2007

Abstract:The present invention is directed to novel formulations and methods for the improved delivery and administration of hydrophobic therapeutic compounds that are substantially insoluble and/or susceptible to precipitation in aqueous solution at physiological pH, including, e.g., growth and differentiation factor-5 and related proteins. Many therapeutic compounds are hydrophobic at physiological pH levels.

Priority: EP20060022159 Applic. Date: 2006-10-23; WO2007EP09198 Applic. Date: 2007-10-23

Inventor: HANSOM LEAH R [US]; FREY II WILLIAM H [US]; HOEKMAN JOHN D [US]; POHL JENS [DE]


Application No.: US20100074974A1  Published: 25/Mar/2010

Title: METAL-RICH SILICEOUS COMPOSITIONS AND METHODS OF PRODUCING SAME

Applicant/Assignee:

Application No.: 12/628472   Filing Date: 01/Dec/2009

Abstract:A modified sol-gel method to create metal-rich siliceous material, such as colloidal silica or aluminosilicate particles is disclosed. Initially, the metal salt of choice is added to a silicic acid solution or a silicic acid solution containing aluminum salt. The aluminum is added to vary the metal-support interaction as it forms Al-O-Si linkages within the silica matrix. Besides aluminum, other metals can be added that form M-O-Si (M=Ti, B, etc.) linkages, which do not become reduced when treated with a reducing agent. Once the metal, silicic acid and/or aluminum salt is generated, it is subjected to colloidal growth by addition to a basic heel. Upon colloidal synthesis, the metal salt containing colloidal particle is left as is to maximize colloidal stability or is reduced with hydrazine to produce the zero valence metal-containing colloidal particle. Keeping a particle colloidal before use may be an effective method of forming a catalyst material as it can be easily spray-dried or mixed with other materials for extruded catalyst particles.

Priority: US2006-557548 Applic. Date: 2006-11-08

Inventor: HOLLAND BRIAN T [US]


Application No.: US20100075359A1  Published: 25/Mar/2010

Title: ANALYTE DETECTION

Applicant/Assignee: N2ITIVE1 INNOVATIONS

Application No.: 09/976872   Filing Date: 12/Oct/2001

Abstract:The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.

Priority: US1999-398552 Applic. Date: 1999-09-17; US2000-698306 Applic. Date: 2000-10-27; US20000243854P Applic. Date: 2000-10-27

Inventor: TORANTO ANTHONY [US]; SINGER EVAN [US]; MILLER BRETT [US]


Application No.: US20100075914A1  Published: 25/Mar/2010

Title: METHODS FOR TREATING HERPES VIRUS INFECTIONS

Applicant/Assignee: NANOBIO CORPORATION

Application No.: 12/425984   Filing Date: 17/Apr/2009

Abstract:The present invention relates to methods for treating, killing, and/or inhibiting the growth of Herpes viruses in human subjects comprising topically administering to a human subject in need thereof a nanoemulsion composition having antiviral properties.

Priority: US20080046262P Applic. Date: 2008-04-18

Inventor: FLACK MARY R [US]; CIOTTI SUSAN MARIE [US]; HAMOUDA TAREK [US]; SUTCLIFFE JOYCE A [US]; BAKER JR JAMES R [US]


Application No.: US20100076068A1  Published: 25/Mar/2010

Title: Aminoalcohol Derivatives and Their Therapeutic Use

Applicant/Assignee:

Application No.: 12/517272   Filing Date: 12/Dec/2007

Abstract:A compound of formula (1) Including pharmaceutically acceptable salts thereof, wherein: R1 is aryl or heteroaryl optionally substituted with R8

R2 is H or alkyl or CH2 (when forming part of a ring with R3, R4 or R5)

R3 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R4 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R5 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R6 is H, alkyl, COH, COOR9, CON(R9)2, COR9, COR10, COR11, P(O)nR9, P(O)nR10S(O)nR10 or S(O)nR9 and can be part of a ring with R2, R3, R4 or R5

R7 is H, alkyl, COOR9, COOR11, COR9 or CON(R9)2, and can be part of a ring with R2, R3, R4, R5 or R6

R8 is alkyl, CF3, OR9, OCOR9, CONH2, CN, F, Cl, Br, I, N(R9)2, NO2, NHCHO, NHCONH2, NHSO2R9, CON(R9)2, S(O)nR9, CH2OH Or OCON(R9)2

R9 is H, alkyl or cycloalkyl

R10 is aryl or heteroaryl (optionally substituted with R8) or a four to seven membered ring (which is optionally substituted with R8 and can contain one or more additional heteroatoms selected from the list O, S(O)n and NR9)

R11 is alkyl optionally substituted with R8 or R10

and n is O, 1 or 2

provided that when R3, R4 or R5 is CH2OH then R6 is not H, and that when R7 is H and R3, R4 and R5 are alkyl then R6 is not H. is of therapeutic use in the treatment of a condition associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines.

Priority: GB20060024757 Applic. Date: 2006-12-12; WO2007GB04752 Applic. Date: 2007-12-12

Inventor: WALMSLEY ANDREA [GB]; LASTERRA ELENA [GB]


Application No.: US20100076080A1  Published: 25/Mar/2010

Title: Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products

Applicant/Assignee:

Application No.: 12/541428   Filing Date: 14/Aug/2009

Abstract:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

Priority: US20080089094P Applic. Date: 2008-08-15

Inventor: YELM KENNETH EDWARD [US]; BUNKE GREGORY MARK [US]; HAUGHT JOHN CHRISTIAN [US]


Application No.: US20100076089A1  Published: 25/Mar/2010

Title: ANTIMICROBIAL GEL FORMULATIONS

Applicant/Assignee: NOVABAY PHARMACEUTICALS, INC

Application No.: 12/540251   Filing Date: 12/Aug/2009

Abstract:Disclosed herein are formulations comprising an N-halogenated or N,N-dihalogenated amine compound dispersed in a water-swellable polymer, wherein the compound is 90% stable for at least 30 days at about 25 DEG C. Also disclosed are methods of treating or preventing infections caused by a bacterial, a microbial, a sporal, a fungal or a viral activity using such formulations.

Priority: US20080088302P Applic. Date: 2008-08-12; US20090229624P Applic. Date: 2009-07-29

Inventor: WANG LU [US]; NAJAFI AZAR [US]; MEMARZADEH BAHRAM [US]; SHARMA KULDEEPAK [US]; HO KIM PHUONG [US]


Application No.: US20100076115A1  Published: 25/Mar/2010

Title: Compositions For Dental Composites With Tricyclo[5.2.1.02.6]decane Derivatives

Applicant/Assignee: HERAEUS KULZER GMBH

Application No.: 12/614560   Filing Date: 09/Nov/2009

Abstract:Dental composites comprising monomers, crosslinking agents, fillers, and initiators, in which the crosslinking agent comprises more than 50% by weight of the acrylate monomer TCD-DI-HEA, and the cyctotoxicity of the cured composite as determined according to the standard requirements of ISO 10993-5 and DIN EN ISO 7405 is assessed into the category "no cytotoxic potential".

Priority: DE200610060983 Applic. Date: 2006-12-20; US2007-953120 Applic. Date: 2007-12-10

Inventor: UTTERODT ANDREAS [DE]; RUPPERT KLAUS [DE]; SCHAUB MATTHIAS [DE]; DIEFENBACH CHRISTINE [DE]; REISCHL KURT [DE]; HOHMANN ALFRED [DE]; ECK MICHAEL [DE]; SCHOENHOF NELLI [DE]


Application No.: US20100080833A1  Published: 01/Apr/2010

Title: STABLE, CONCENTRATED AND DILUTE, OIL-IN-WATER EMULSIONS, THEIR PROCESSES OF PREPARATION, AND FORMULATION PROCESS EMPLOYING THESE EMULSIONS

Applicant/Assignee: J & C INTERNATIONAL

Application No.: 12/630870   Filing Date: 04/Dec/2009

Abstract:A stable oil-in-water emulsion, a process for the preparing such emulsion, and a formulation process employing the emulsion. The stable oil-in-water emulsion is obtained from an air-in-water preemulsion to which a simple or complex fatty substance is added by moderate mixing, preferably without exerting a shear force. The air-in-water preemulsion includes a surfactant, preferably a nonionic surfactant, a co surfactant chosen from hydrophilic compounds, preferably having at least one hydroxyl group, which are chosen in particular from the family of the polyols, and an aqueous phase. The ratios of these three components of the preemulsion are chosen within the region of ordered liquid crystal structure of the phase diagram of these three components and/or in ratios chosen so that the structure of the mixture of these three components, observed under a microscope in polarized light, exhibits birefringence characteristics.

Priority: FR20030009861 Applic. Date: 2003-08-12; US2004-487786 Applic. Date: 2004-08-23; WO2004FR00122 Applic. Date: 2004-01-20

Inventor: ROSSOW VERONIQUE [FR]; ROSSOW NICOLAS [FR]; ROSSOW JEAN [FR]


Application No.: US20100080836A1  Published: 01/Apr/2010

Title: METHOD AND MEANS FOR CULTURING OSTEOBLASTIC CELLS

Applicant/Assignee: ASCENDIA AB

Application No.: 12/598811   Filing Date: 02/May/2008

Abstract:A method of culturing human or mammalian mesenchymal stem cells (MSC) or osteoblastic cells to form corresponding cell aggregates evenly distributed in the culturing medium having a reduced content of cells with fibroblast morphology comprises contacting MSC or OC with a water-soluble cellulose derivative over a period of from 1 day to one or two weeks. Also disclosed are a corresponding aggregates, a culture medium and a pharmaceutical composition, and uses of the aggregate, the culturing medium and the composition.

Priority: SE20070001078 Applic. Date: 2007-05-04; WO2008SE00307 Applic. Date: 2008-05-02

Inventor: BUSCH CHRISTER [SE]


Application No.: US20100081113A1  Published: 01/Apr/2010

Title: DENTAL ROOT CANAL-FILLING COMPOSITION

Applicant/Assignee: GC CORPORATION

Application No.: 12/560917   Filing Date: 16/Sep/2009

Abstract:To provide a dental root canal-filling composition which is generally formed in a point shape, has high strength, is properly deformed so as to afford easy operativity for filling in a root canal, has improved wetting and adhering properties with a root canal-filling sealer and is less deteriored by sterilization or chemical disinfection, the dental root canal-filling composition comprises one or more kinds of polyolefin resins selected from the group of polyethylene, polypropylene, and a copolymer of polyethylene and polypropylene, a styrene block copolymer, one or more kinds of thermoplastic resins selected from the group of ester gum, rosin, an alicyclic saturated hydrocarbon resin, a terpene resin, and an aliphatic petroleum resin, and one or more kinds of inorganic fillers selected from the group of zinc oxide, barium sulfate, zirconium oxide, titanium oxide, ytterbium fluoride, a barium glass, and an aluminosilicate glass.

Priority: JP20080251990 Applic. Date: 2008-09-30

Inventor: SHINOZAKI YUTAKA [JP]; KAMOHARA HIROSHI [JP]


Application No.: US20100081728A1  Published: 01/Apr/2010

Title: Mixable and color tone freely reproducible dental coloring material composition, and set and method thereof

Applicant/Assignee: KABUSHIKI KAISHA SHOFU

Application No.: 12/458141   Filing Date: 01/Jul/2009

Abstract:A dental coloring material composition comprising containing: (a) a polymerizable monomer and/or an oligomer, (b) a polymerization catalyst, and (c) a pigment and/or a dye, wherein a color tone thereof is a cyan color based on three subtractive primary colors, or a color tone thereof is a magenta color based on three subtractive primary colors, or a color tone thereof is a yellow color based on three subtractive primary colors, and a dental color material set using the dental coloring material compositions in combination.

Priority: JP20080256427 Applic. Date: 2008-10-01

Inventor: UCHIDA JUN [JP]; OKIMOTO YUSHIN [JP]; TERAMAE MITSUJI [JP]; MIZUNO MITSUHARU [JP]


Application No.: US20100083706A1  Published: 08/Apr/2010

Title: Lithium silicate glass ceramic for fabrication of dental appliances

Applicant/Assignee: JAMES R., GLIDEWELL DENTAL CERAMICS, INC

Application No.: 12/592825   Filing Date: 03/Dec/2009

Abstract:The present invention relates to preparing an improved lithium silicate glass ceramic for the manufacture of blocks for dental appliance fabrication using a CAD/CAM process and hot pressing system. The lithium silicate material has a chemical composition that is different from those reported in the prior art with 1 to 10% of germanium dioxide in final composition. The softening points are close to the crystallization final temperature of 830 DEG C. indicating that the samples will support the temperature process without shape deformation.

Priority: US2008-283472 Applic. Date: 2008-09-12; US2008-082576 Applic. Date: 2008-04-11

Inventor: CASTILLO RODOLFO [US]


Application No.: US20100083850A1  Published: 08/Apr/2010

Title: SCREW PRESS FOR COMPACTING SOLID WASTE

Applicant/Assignee:

Application No.: 12/522007   Filing Date: 17/Jan/2008

Abstract:Screw press, with small dimensions, particularly suitable for the compaction of solid waste for disposal also by means of sorted-waste collection, of the type which comprises an initial large-diameter screw section with a wide-pitch helix, communicating laterally with the bottom opening of the loading hopper (1) in order to remove the material from it and feed it to a following small-diameter screw section with a small-pitch helix, surrounded by an internally scored stator body so as to produce the feeding and compaction of the material which also occurs in conjunction with the action of constriction means which act on the discharge mouth of this latter screw section, a press of this type being characterized in that the two said aforementioned screw sections (3, 4) are separated and arranged parallel to each other and one above or around each other, so as to form overall a press which no longer has as its length the sum of the lengths of the said two screw sections, but which has a length corresponding to the length of the longer of the two screw sections, means being envisaged for operating said two screw sections at different speeds, with the second compacting screw section (4) which rotates at a speed greater than that of the first feeder screw section (3).

Priority: IT2007BO00021 Applic. Date: 2007-01-18; WO2008EP50498 Applic. Date: 2008-01-17

Inventor: SALDA LUCIANO [IT]


Application No.: US20100084364A1  Published: 08/Apr/2010

Title: Container Closure Comprising a Cable Tie

Applicant/Assignee: JUNKK.COM LIMITED

Application No.: 12/445577   Filing Date: 17/Oct/2007

Abstract:A tamper evident lid assembly (10) for a mouth of a container (12) comprises a lid (15) to close the mouth of the container, and a strip (14) preventing removal of the lid. Removal or disconnection of the strip (14) enables the lid (15) to be removed. The strip (14) defines at one end a block (20) with an aperture (24), and also defines serrated teeth (22) along at least part of its length, such that after removing the strip from the lid assembly it may be used as a cable tie.

Priority: GB20060020483 Applic. Date: 2006-10-17; WO2007GB50641 Applic. Date: 2007-10-17

Inventor: MARTIN PETER JOHN [GB]


Application No.: US20100084377A1  Published: 08/Apr/2010

Title: Method for Girth Welding Metallic Pipes

Applicant/Assignee:

Application No.: 12/593561   Filing Date: 17/Mar/2008

Abstract:A method for girth welding of metallic pipes consists in beveling one pipe end in order that, when it is aligned with an identically beveled pipe end on another pipe, results in a bevel of a "cruet" design with a rounded bottom part larger than an upper part with parallel walls. The diameter of the welding wire used for the welding method is within 1.2 and 1.4 mm and the wire contains low levels of impurity including sulfur and phosphorus. The welding technique used is a "strip" technique which does not provide employ weaving or oscillation of the welding torch.

Priority: IT2007PD00117 Applic. Date: 2007-03-29; WO2008US03510 Applic. Date: 2008-03-17

Inventor: BELLONI ANTONIO [IT]; BELLONI MARCO [IT]


Application No.: US20100086499A1  Published: 08/Apr/2010

Title: TOOTH WHITENING COMPOSITION

Applicant/Assignee:

Application No.: 12/300351   Filing Date: 11/May/2007

Abstract:The present invention provides an effective tooth whitening composition comprising a chlorine dioxide precursor, an organic acid anhydride and an orally acceptable carrier.

Priority: GB20060009485 Applic. Date: 2006-05-12; WO2007EP54601 Applic. Date: 2007-05-11

Inventor: BURNETT GARY ROBERT [GB]; GORDON JENNIFER JANE [GB]; VELADA JOSE LUIS [GB]


Application No.: US20100086528A1  Published: 08/Apr/2010

Title: NOVEL BACTERIA ISOLATED FROM FRESH HONEY OR THE HONEY PRODUCING TRACT OF HONEY BEES

Applicant/Assignee:

Application No.: 12/598509   Filing Date: 30/Apr/2008

Abstract:The invention relates to new isolated Lactobacillus and Bifidobacterium strains which have been isolated from fresh honey having a water content above 18% by weight or from the honey producing tract of at least one bee. The bacterial strains have unique properties rendering them useful in many products such as in food and beverage products, feed products and medica products.

Priority: SE20070001050 Applic. Date: 2007-05-03; US20070916809P Applic. Date: 2007-05-09; WO2008SE00303 Applic. Date: 2008-04-30

Inventor: OLOFSSON TOBIAS [SE]; VASQUEZ ALEJANDRA [SE]


Application No.: US20100086618A1  Published: 08/Apr/2010

Title: Methods and Systems for Mineralization of Demineralized Tissue

Applicant/Assignee: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC

Application No.: 12/576058   Filing Date: 08/Oct/2009

Abstract:Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.

Priority: US20080195561P Applic. Date: 2008-10-08

Inventor: PASHLEY DAVID HENRY [US]; TAY FRANKLIN CHI-MENG [US]


Application No.: US20100086891A1  Published: 08/Apr/2010

Title: TOOTH WHITENING APPARATUS

Applicant/Assignee:

Application No.: 12/519214   Filing Date: 14/Dec/2006

Abstract:Provided is a tooth whitening apparatus. The tooth whitening apparatus includes a whitening unit having a light emitting part emitting light to all of teeth of a patient

and a wearable set to which the whitening unit is mounted, the wearable set being worn on head of the patient.

Priority: WO2006KR05453 Applic. Date: 2006-12-14

Inventor: JUN JONG-CHAN [KR]


Application No.: US20100086897A1  Published: 08/Apr/2010

Title: ELASTIC TEMPORARY SUPRACONSTRUCTION FOR A DENTAL IMPLANT

Applicant/Assignee: VOCO GMBH

Application No.: 12/442963   Filing Date: 26/Sep/2007

Abstract:A temporary supraconstruction for a dental implant or a core for a temporary supraconstruction for a dental implant, characterized in that it includes a material having a modulus of elasticity of less than 300 MPa, preferably in the range of from 15 to 20 MPa.

Priority: DE200610045466 Applic. Date: 2006-09-26; WO2007EP60236 Applic. Date: 2007-09-26

Inventor: SCHULZ-WALZ JAN ERIK [DE]


Application No.: US20100087103A1  Published: 08/Apr/2010

Title: ELECTRICAL TERMINATION

Applicant/Assignee: TYCO ELECTRONICS CORPORATION

Application No.: 12/244507   Filing Date: 02/Oct/2008

Abstract:A crimped wire termination is disclosed for electrically terminating thereto a stainless steel wire. The termination includes a barrel having a concave spine and opposing fingers on either end of the spine extending outwardly from the spine at symmetrical angles. The fingers are adapted to encircle an end of a wire. An indentation formed in the spine when crimped. The indentation forms a segment of the barrel having a cross-sectional diameter less than a cross-sectional diameter of an adjacent end of the barrel, and forms a bend in the wire at opposite ends of the segment, to prevent axial movement through the barrel.

Priority:

Inventor: DECKER DONALD F [US]; DESANTIS PETE [US]; PORTA GARY D [US]; HOWARD EDWARD J [US]; SCHWARTZ THOMAS G [US]


Application No.: US20100087471A1  Published: 08/Apr/2010

Title: INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/568085   Filing Date: 28/Sep/2009

Abstract:The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Priority: US20080101054P Applic. Date: 2008-09-29; US20090225452P Applic. Date: 2009-07-14

Inventor: SCHRIMPF MICHAEL R [US]; LEE CHIH-HUNG [US]; LI TAO [US]; GFESSER GREGORY A [US]; MORTELL KATHLEEN H [US]; FAGHIH RAMIN [US]; NERSESIAN DIANA L [US]; SIPPY KEVIN B [US]; BUNNELLE WILLIAM H [US]; SCANIO MARC [US]; SHI LEI [US]; GOPALAKRISHNAN MURALI [US]; DONNELLY-ROBERTS DIANA L [US]; HU MIN [US]


Application No.: US20100087480A1  Published: 08/Apr/2010

Title: SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS

Applicant/Assignee: PFIZER INC

Application No.: 12/445500   Filing Date: 11/Oct/2007

Abstract:This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

Priority: US20060862485P Applic. Date: 2006-10-23; WO2007IB03106 Applic. Date: 2007-10-11

Inventor: ANDO KOJI [JP]; TANAKA HIROTAKA [JP]


Application No.: US20100087563A1  Published: 08/Apr/2010

Title: SULPHONIUM SALT PHOTOINITIATORS

Applicant/Assignee:

Application No.: 12/442823   Filing Date: 24/Sep/2007

Abstract:Compounds of the formula (I), wherein L1, L2, L3 and L4 independently of one another are hydrogen or an organic substituent

R is for example C1-C20alkyl, C5-C12cycloalkyl, C2-C20alkenyl, substituted C1-C20alkyl

X is O, S, NRa or NCORa

Ra is for example hydrogen or C1-C20alkyl

and Y is an inorganic or organic anion

are suitable as photolatent acid generators.

Priority: EP20060121699 Applic. Date: 2006-10-04; WO2007EP60074 Applic. Date: 2007-09-24

Inventor: HAYOZ PASCAL [CH]; BIRBAUM JEAN-LUC [CH]; ILG STEPHAN [CH]


Application No.: US20100087565A1  Published: 08/Apr/2010

Title: Dental Composites with a Low Shrinkage Tension and High Flexural Strength

Applicant/Assignee: HERAEUS KULZER GMBH

Application No.: 12/635114   Filing Date: 10/Dec/2009

Abstract:Dental composite materials based on (meth)acrylate, exhibiting a proportion of TCD monomers in the total composition of 1-15% by weight and the quotient of flexural strength/shrinkage tension is at least 35.

Priority: DE200710034457 Applic. Date: 2007-07-20; US2008-168512 Applic. Date: 2008-07-07

Inventor: UTTERODT ANDREAS [DE]; RUPPERT KLAUS [DE]; SCHAUB MATTHIAS [DE]; DIEFENBACH CHRISTINE [DE]; REISCHL KURT [DE]; HOHMANN ALFRED [DE]; ECK MICHAEL [DE]; SCHONHOF NELLI [DE]; SCHNEIDER JUTTA [DE]


Application No.: US20100087613A1  Published: 08/Apr/2010

Title: DIVIDED REDOX-CURING TYPE COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/524043   Filing Date: 16/Jan/2008

Abstract:The present invention provides a divided redox-curing type composition including a first part in which at least an oxidizing agent (b) is dissolved in a first radical monomer including a radical monomer (a) having an acidic group and/or a hydrophilic group

and a second part in which at least an aromatic sulfinate (d) is dispersed in a second radical monomer including a radical monomer (c) having neither an acidic group nor a hydrophilic group. According to the present invention, a redox-curing type composition capable of securing a time necessary for an adhesion operation and exhibiting high bond strength not only at the initial stage of adhesion but also over a long period of time thereafter in application to a wetting material such as a tooth or a bone as well as a tooth crown repairing material such as a metal or porcelain.

Priority: JP20070012740 Applic. Date: 2007-01-23; WO2008JP50399 Applic. Date: 2008-01-16

Inventor: TAKEI MITSURU [JP]; NAKAYAMA HIDEMI [JP]; SHINODA HIROKI [JP]


Application No.: US20100087710A1  Published: 08/Apr/2010

Title: Integrated Locking Device With Fluid Control

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 12/467968   Filing Date: 18/May/2009

Abstract:Endoscope assemblies, biopsy caps, and methods for making and using the same. An example endoscope assembly may include an endoscope having a channel formed therein and a port that provides access to the channel. A cap may be coupled to the port. The cap may include a base having a securing member for securing the cap to the port. The cap may also include an outer shell, a locking member coupled to the outer shell, an inner seal member disposed within the outer shell, and one or more openings extending through the cap and into the channel. A fluid control region may be defined within the outer shell.

Priority: US20080054413P Applic. Date: 2008-05-19

Inventor: WELDON JAMES M [US]; BYERS RANSOM H [US]; DILLON ALEXANDER E [US]; KOCHEM THOMAS C [US]; RICE DANIEL W [US]; SCHMIDT ALLISON L [US]; NIX LILLY [US]; CLARK LARA [US]; DONOHOO PEARL E [US]; HOLLETT ANDREW K [US]; LITTLE CHANDRA [US]


Application No.: US20100087749A1  Published: 08/Apr/2010

Title: Collection Device for Sampling Exhaled Airstreams

Applicant/Assignee:

Application No.: 12/524781   Filing Date: 31/Jan/2008

Abstract:A collection device (10), such as a mask, for collecting constituents of interest present in an airstream exhaled by a subject The collection device comprises a support member (12) mountable external to the nose and/or mouth of the subject, and at least one collection region (13) mounted to the support member (12) for collecting at least some of said constituents. The constituents are collected in a manner that allows subsequent analysis of the constituents. When the support member (12) is mounted over the nose and/or mouth of the subject, at least some of the exhaled airstream passes through the at least one collection region (13).

Priority: AU20070900458 Applic. Date: 2007-01-31; AU20070903984 Applic. Date: 2007-07-25; WO2008AU00100 Applic. Date: 2008-01-31

Inventor: TOVEY EUAN ROGER [AU]


Application No.: US20100087769A1  Published: 08/Apr/2010

Title: BIOCIDIC MEDICAL DEVICES, IMPLANTS AND WOUND DRESSINGS

Applicant/Assignee: OPLON B.V

Application No.: 12/598429   Filing Date: 03/Apr/2008

Abstract:The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity

and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

Priority: US20070924154P Applic. Date: 2007-05-01; WO2008IL00467 Applic. Date: 2008-04-03

Inventor: BUKSHPAN SHMUEL [IL]; ZILBERSTEIN GLEB [IL]


Application No.: US20100089200A1  Published: 15/Apr/2010

Title: ROTARY UNITS, ROTARY MECHANISMS, AND RELATED APPLICATIONS

Applicant/Assignee:

Application No.: 12/577326   Filing Date: 12/Oct/2009

Abstract:The invention relates to rotary units and rotary mechanisms that are suitable for use in numerous applications. Rotary units typically include rotational components that are configured to rotate. In some embodiments, for example, multiple rotary units are assembled in rotary mechanisms such that neighboring pairs of rotational components counter-rotate or contra-rotate relative to one another during operation of the rotary mechanisms. Rotational components generally include one or more implements that are structured to perform or effect one or more types of work as the rotational components rotate relative to one another in a given rotary mechanism. In certain embodiments, implements are configured to rotate and/or to effect the movement of other components as rotational components rotate.

Priority: US20080104748P Applic. Date: 2008-10-12

Inventor: SAPPENFIELD CHRISTOPHER C [US]


Application No.: US20100089863A1  Published: 15/Apr/2010

Title: PLASTIC BOTTLE WITH A MOUTH

Applicant/Assignee: THE COCA-COLA COMPANY

Application No.: 12/251663   Filing Date: 15/Oct/2008

Abstract:To provide a plastic bottle whose weight can be reduced without sacrificing strength of a bottle mouth, the plastic bottle is provided with a bottle mouth having a circumferential wall, including a threaded section formed on an outer circumferential surface of the circumferential wall, a support ring protruding from the outer circumferential surface below the threaded section, and punched sections formed on the circumferential wall.

Priority:

Inventor: MATSUOKA KENSHI [JP]


Application No.: US20100090157A1  Published: 15/Apr/2010

Title: ADHESIVE COMPOSITION FOR HARD TISSUE

Applicant/Assignee:

Application No.: 12/520703   Filing Date: 17/Dec/2007

Abstract:An adhesive composition including an etchant for a hard tissue surface, at least one multifunctional crosslinkable (meth)acrylate monomer with a functionality greater than 4, and water. The adhesive composition is a water-in-oil emulsion.

Priority: US20060877514P Applic. Date: 2006-12-28; WO2007US87711 Applic. Date: 2007-12-17

Inventor: RAO PRABHAKARA S [US]; AASEN STEVEN M [US]; ABUELYAMAN AHMED S [US]; MITRA SUMITA B [US]; CRAIG BRADLEY D [US]; SHUKLA BRIAN A [US]; PLAUT DAVID J [US]; RUSSELL VICTORIA A [US]


Application No.: US20100092406A1  Published: 15/Apr/2010

Title: Systems, Methods, and Compositions for Treatment and Use of a Palatal Patch

Applicant/Assignee:

Application No.: 12/440024   Filing Date: 15/Aug/2007

Abstract:Devices and methods for a palatal patch include a tablet or strip having a bioadhesive component and an active component. The bioadhesive component allows for the palatal patch to be attached to an upper palate, and for the active component to be released into the oral cavity and/or GI tract. Compositions for the active component include compositions for treatment of halitosis, anti-acids, vitamins, anti-smoking agents, and others. A composition for treatment of halitosis includes at least one of Echinacea, Lavender, Mastic Gum and Sage. A device for delivery of the palatal patch to the upper palate includes a housing and a piston, the piston having a holder for the palatal patch, and wherein the piston may be configured to move distally so as to delivery the palatal patch to the upper palate.

Priority: US20060824476P Applic. Date: 2006-09-05; WO2007IL01024 Applic. Date: 2007-08-15

Inventor: PEREZ-DAVIDI MICHAEL MOSHE [IL]; STERER NIR [IL]; WEISS ERVIN ITZCHAK [IL]; DOMB AVRAHAM JACOB [IL]


Application No.: US20100093605A1  Published: 15/Apr/2010

Title: PEPTIDES, DERIVATIVES AND ANALOGS THEREOF, AND METHODS OF USING SAME

Applicant/Assignee: CUREDM, INC

Application No.: 12/635053   Filing Date: 10/Dec/2009

Abstract:Human proIslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human proIslet Peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, and/or lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome.

Priority: US2008-121123 Applic. Date: 2008-05-15; US2006-441491 Applic. Date: 2006-05-25; US20050684819P Applic. Date: 2005-05-25

Inventor: LEVETAN CLARESA S [US]; UPHAM LORAINE V [US]


Application No.: US20100093671A1  Published: 15/Apr/2010

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636329   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGE RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]


Application No.: US20100093698A1  Published: 15/Apr/2010

Title: AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Applicant/Assignee:

Application No.: 12/555018   Filing Date: 08/Sep/2009

Abstract:Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Priority: US20080095217P Applic. Date: 2008-09-08; US20090230479P Applic. Date: 2009-07-31

Inventor: BAHMANYAR SOGOLE [US]; BATES R J [US]; BLEASE KATE [US]; CALABRESE ANDREW ANTONY [US]; DANIEL THOMAS ORAN [US]; DELGADO MERCEDES [US]; ELSNER JAN [US]; ERDMAN PAUL [US]; FAHR BRUCE [US]; FERGUSON GREGORY [US]; LEE BRANDEN [US]; NADOLNY LISA [US]; PACKARD GARRICK [US]; PAPA PATRICK [US]; PLANTEVIN-KRENITSKY VERONIQUE [US]; RIGGS JENNIFER [US]; ROHANE PATRICIA [US]; SANKAR SABITA [US]; SAPIENZA JOHN [US]; SATOH YOSHITAKA [US]; SLOAN VICTOR [US]; STEVENS RANDALL [US]; TEHRANI LIDA [US]; TIKHE JAYASHREE [US]; TORRES EDUARDO [US]; WALLACE ANDREW [US]; WHITEFIELD BRANDON WADE [US]; ZHAO JINGJING [US]


Application No.: US20100093708A1  Published: 15/Apr/2010

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636306   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGE RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]


Application No.: US20100093740A1  Published: 15/Apr/2010

Title: 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

Applicant/Assignee:

Application No.: 12/520693   Filing Date: 20/Dec/2007

Abstract:The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), wherein X represents CH2 or O

R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl

R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl

R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen

R4 represents (C1-4)alkyl

R5 represents hydrogen or (C1-4)alkyl

and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds

and to the use of such compounds as medicaments

especially as orexin receptor antagonists.

Priority: WO2006IB55019 Applic. Date: 2006-12-22; WO2007IB55245 Applic. Date: 2007-12-20

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]


Application No.: US20100093788A1  Published: 15/Apr/2010

Title: HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS

Applicant/Assignee:

Application No.: 12/576283   Filing Date: 09/Oct/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.

Priority: US20080105449P Applic. Date: 2008-10-15

Inventor: PLAYER MARK R [US]; PARKS DANIEL J [US]; PARSONS WILLIAM [US]; MEEGALLA SENATH K [US]; ILLIG CARL R [US]; BALLENTINE SHELLEY K [US]


Application No.: US20100094090A1  Published: 15/Apr/2010

Title: SELF-CLEANING WIRELESS VIDEO STYLET WITH DISPLAY MOUNTED TO LARYNGOSCOPE BLADE AND METHOD FOR USING THE SAME

Applicant/Assignee:

Application No.: 12/623552   Filing Date: 23/Nov/2009

Abstract:A scope adapted for insertion and manipulation in a difficult pathway is disclosed. The scope comprises at least one module for manipulating the scope. The scope may further comprise an illumination source, an image sensor, a power source, and a viewing member for viewing images of a cavity or other anatomical member of a patient. In one embodiment the scope is intended to facilitate insertion of an intubating device, which comprises an elongated semi-rigid stylet including first and second ends and at least one inner lumen connected to a module. Additionally, a flexible tip is provided for manipulating one end of the scope and allowing greater flexibility when maneuvering a difficult pathway. In another embodiment, fluids are provided through an interior portion of the scope, allowed to at least partially contact the lens located at the distal end of the scope, and subsequently cleanse or defog the lens for improving vision via the scope. A method for navigating a difficult pathway and for using the apparatus described herein is also disclosed.

Priority: US2008-253729 Applic. Date: 2008-10-17; US2008-020862 Applic. Date: 2008-01-28

Inventor: MEJIA MAURICIO [US]


Application No.: US20100095561A1  Published: 22/Apr/2010

Title: BUCKET THAT IS APPLICABLE INTERCHANGEABLY TO OPERATING MACHINES PROVIDED WITH HYDRAULIC OR ELECTRIC PLANT

Applicant/Assignee:

Application No.: 12/311925   Filing Date: 30/Aug/2007

Abstract:A bucket (B) that is applicable interchangeably to operating machines provided with hydraulic or electric plant, equipped with one or more rotors (R) actuated by one or more hydraulic or electric (M) engines or gear motors fed by the hydraulic or electric circuit resting inside operating machines or outside the bucket.

Priority: IT2006BO00722 Applic. Date: 2006-10-20; WO2007IB02500 Applic. Date: 2007-08-30

Inventor: RISI MIRCO [IT]


Application No.: US20100097777A1  Published: 22/Apr/2010

Title: Symbiotic Containment Enclosure

Applicant/Assignee:

Application No.: 12/426510   Filing Date: 20/Apr/2009

Abstract:A package for, interacting symbiotically, integrally and exclusively with and for patent application number 11758760 electromagnetic circuit. Such package is comprised of one or more layers of materials moderating the circuits electromagnetic field within. Such a package has proximal inductors that are electromagnetic conduits for input and output of electromagnetic energy terminating proximally in relation to the circuit within.

Priority: US2007-758760 Applic. Date: 2007-06-06

Inventor: MECCA JOHN [US]


Application No.: US20100098643A1  Published: 22/Apr/2010

Title: ORAL HEALTH COMPOSITION

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/516294   Filing Date: 27/Nov/2007

Abstract:The present invention relates to Orthosiphon spicatus for use in oral health applications, an oral composition comprising Orthosiphon spicatus, and the use of Orthosiphon spicatus or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes Orthosiphon spicatus for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal.

Priority: GB20060023618 Applic. Date: 2006-11-27; WO2007GB04526 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]


Application No.: US20100098732A1  Published: 22/Apr/2010

Title: METHODS, PROCESSES AND COMPOSITIONS COMPRISING THE PROTEIN CALMODULIN (CAM) FOR TREATMENT OF DAMAGED OR AGING SKIN, AND/OR HAIR LOSS

Applicant/Assignee:

Application No.: 12/449916   Filing Date: 21/Mar/2007

Abstract:The invention relates to compositions comprising the calcium binding protein, calmodulin (CaM), and the use of this protein additive in compositions suitable for topical application for the maintenance and development of healthy skin

for improving the aesthetic appearance of skin

for treating fine lines, and/or wrinkles, and/or age spots, and/or minor wounds and burns, and/or calloused skin-through its facilitation of natural healing processes initiated by disease, injury or aging

for enhancing hair growth

and as a cosmetic treatment process comprising application to the skin the compositions, preferably on a daily basis. The compositions may comprise, but not be limited to, UV blocking agents and/or penetration enhancers and/or one or more bio-active agents. CaM can be formulated into therapeutic compositions as lotions, creams, ointments, sprays, gels, skin coverings and wound dressings.

Priority: WO2007IB02725 Applic. Date: 2007-03-21

Inventor: TIPPENS DORR FELT [US]


Application No.: US20100098733A1  Published: 22/Apr/2010

Title: Nitric oxide releasing particles for oral care applications

Applicant/Assignee: NOVAN, INC

Application No.: 12/580418   Filing Date: 16/Oct/2009

Abstract:The present invention provides an oral care composition Comprising a nitric oxide releasing particle and an orally-acceptable carrier. The nitric oxide releasing particle comprises at least one nitric oxide donor. Another aspect of the present invention provides a device for oral care comprising a nitric oxide releasing particle, wherein the device is configured to expose a targeted site in an oral cavity of a subject to nitric oxide. The present invention also provides methods and uses of providing oral health benefits by using the oral care compositions or devices as described above.

Priority: US20080105951P Applic. Date: 2008-10-16

Inventor: STASKO NATHAN [US]


Application No.: US20100098745A1  Published: 22/Apr/2010

Title: Methods for delivery of medication using dissolvable devices

Applicant/Assignee:

Application No.: 12/587985   Filing Date: 16/Oct/2009

Abstract:A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of films, fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the films, fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.

Priority: US2008-287253 Applic. Date: 2008-10-08; US20070998383P Applic. Date: 2007-10-11

Inventor: STAAB ROBERT J [US]


Application No.: US20100098774A1  Published: 22/Apr/2010

Title: COMPOSITION COMPRISING CRUSTACEAN GASTROLITH COMPONENTS AND ITS USE

Applicant/Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

Application No.: 12/443987   Filing Date: 07/Oct/2007

Abstract:Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.

Priority: IL20060178495 Applic. Date: 2006-10-05; WO2007IL01211 Applic. Date: 2007-10-07

Inventor: BEN YOSSI [IL]; SAGI AMIR [IL]


Application No.: US20100098791A1  Published: 22/Apr/2010

Title: COMPOSITION FOR TREATING XEROSTOMIA OR DRY MOUTH

Applicant/Assignee:

Application No.: 12/527753   Filing Date: 22/Feb/2008

Abstract:The present invention provides a composition comprising olive oil, trimethylglycine and xylitol for treating xerostomia and disorders associated thereto, with very good results in increasing the unstimulated salivary flow, in alleviating the symptoms of xerostomia, including the pain associated to xerostomia, as well as improving the quality of life of affected persons. The composition of the invention has also been proved to protect dentin against demineralization in acid conditions.

Priority: ES20070000464 Applic. Date: 2007-02-22; WO2008ES00100 Applic. Date: 2008-02-22

Inventor: RODRIGUEZ-VILABOA DEBORA [ES]


Application No.: US20100099728A1  Published: 22/Apr/2010

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/577799   Filing Date: 13/Oct/2009

Abstract:This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof

or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Priority: US20080106410P Applic. Date: 2008-10-17

Inventor: CHAFEEV MIKHAIL [CA]; CHOWDHURY SULTAN [CA]; FRASER LAUREN [CA]; FU JIANMIN [CA]; LANGILLE JONATHAN [US]; LIU SHIFENG [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]; WOOD MARK [CA]; ZENOVA ALLA [CA]


Application No.: US20100099758A1  Published: 22/Apr/2010

Title: Regenerative wound healing using copper-silver citrate composition

Applicant/Assignee: MI HOPE INC

Application No.: 12/288749   Filing Date: 22/Oct/2008

Abstract:A composition containing copper and silver ions electrolytically generated in a solution of citric acid that also contains potassium carbonate is shown to expedite the healing of wounds with regeneration of normal tissue architecture and without excessive scarring. A wide range of wounds and other forms of tissue damage affecting the skin and other areas of the body respond favorably to the direct application of the composition, with expedited healing, re-growth of normal appearing (non-scar) tissue and symptomatic relief from pain and swelling. The composition acts in both humans and animals through a novel mechanism provisionally termed the tissue regeneration induced pathway (TRIP).

Priority:

Inventor: MARTIN WILLIAM JOHN [US]; PALMER STEPHEN BENET [US]


Application No.: US20100099855A1  Published: 22/Apr/2010

Title: RECOMBINANT PROTEIN COMPRISING STARCH BINDING DOMAIN AND USE THEREOF

Applicant/Assignee: SIMPSON BIOTECH CO., LTD

Application No.: 12/643304   Filing Date: 21/Dec/2009

Abstract:A recombinant protein is prepared comprising a polypeptide of interest and a starch binding domain (SBD). The said SBD is obtainable from glucoamylase of fungi genus Rhizopus. The said recombinant protein comprising the said SBD can be purified by contacting with an affinity matrix such as starch, the SBD binds to the affinity matrix to isolate the recombinant protein. The recombinant protein can be purified by separating the association between the SBD and the affinity matrix by acid, alkaline, salt, or sugar. The polypeptide of interest may be an antibody, an antigen, a therapeutic compound, an enzyme, or a protein and may apply in pathogen destruction, vaccine producing, and oral care product manufacturing. The SBD further provides as a tool to screen or identify polysacchrides.

Priority: US2005-070271 Applic. Date: 2005-03-03

Inventor: CHANG MARGARET DAH-TSYR [TW]; SHEU CHIA-CHIN [TW]


Application No.: US20100101453A1  Published: 29/Apr/2010

Title: One-pack type dental adhesive composition

Applicant/Assignee: KABUSHIKI KAISHA SHOFU

Application No.: 12/585974   Filing Date: 30/Sep/2009

Abstract:Disclosed is a one-pack type dental adhesive composition comprising: (a) 1.0 to 40.0 parts by weight of a silane coupling agent, (b) 0.01 to 0.4 part by weight of a weak acidic compound which is at least one of organic acid, boric acid and silicic acid, and has an acid dissociation exponent pKa of 3 or more in the form of an aqueous solution, (c) 0.01 to 0.4 part by weight of a strong acidic compound which is at least one of HF, HCl, HBr, HI, HNO3, HClO3, HClO4, HBrO4, HMnO4, H2SO4 and H3PO4 and has an acid dissociation exponent pKa of less than 3, (d) 0.1 to 5.0 part by weight of water, and (e) 20.0 to 99.0 parts by weight of a volatile organic solvent.

Priority: JP20080272887 Applic. Date: 2008-10-23

Inventor: TANAKA HISAKI [JP]; FUJII TOSHIHIDE [JP]; YAMAGUCHI YUTAKA [JP]; DEGUCHI MIKITO [JP]


Application No.: US20100104515A1  Published: 29/Apr/2010

Title: USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

Applicant/Assignee:

Application No.: 12/159363   Filing Date: 29/Dec/2006

Abstract:There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Priority: GB20050026552 Applic. Date: 2005-12-29; WO2006GB04947 Applic. Date: 2006-12-29

Inventor: KNOX RICHARD J [GB]


Application No.: US20100104539A1  Published: 29/Apr/2010

Title: PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/428908   Filing Date: 23/Apr/2009

Abstract:Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

Priority: US2008-206508 Applic. Date: 2008-09-08; US20070989299P Applic. Date: 2007-11-20; US20070986665P Applic. Date: 2007-11-09; US20070970780P Applic. Date: 2007-09-07

Inventor: DANIEL JOHN [US]; TOFE ROBERT [US]; SPENCER RANDALL [US]; RUSSO JOHN [US]


Application No.: US20100104652A1  Published: 29/Apr/2010

Title: Use of advanced nanomaterials for increasing sepecific cell functions

Applicant/Assignee: UNIVERSITY OF ARKANSAS

Application No.: 12/588679   Filing Date: 23/Oct/2009

Abstract:Disclosed herein are methodologies and compositions for enhancing cellular functions, which can be used in a variety of biological applications.

Priority: US20080197424P Applic. Date: 2008-10-27

Inventor: BIRIS ALEXANDRU S [US]; MAHMOOD MEENA [US]; JENSEN PEDER [US]


Application No.: US20100104979A1  Published: 29/Apr/2010

Title: ALPHA-HYDROXYKETONES

Applicant/Assignee:

Application No.: 12/593025   Filing Date: 25/Mar/2008

Abstract:Compounds of the Formula (I) wherein x is an integer from 1-4

p is an integer from 1-3

q is an integer from 0-3

Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5alkenyl or C1-C6alkyl which optionally is substituted by one or more OR6, COOR or halogen

R1 if x is 1, is ORS, O-X+, NR8R9, C1-C20alkyl optionally substituted by one or more COOR10, or is C2-C20alkyl interrupted by one ore more O, or is C2-C5alkenyl or phenyl-C1-C4alkyl

R1 if x is 2, is for example C1-C20alkylene

R1 if x is 3, is for example a tri-valent radical

R1if x is 4, is for example a tetravalent radical

R2and R3are hydrogen or C1-C8alkyl, or R2and R3 together are O, C1-C3alkylene or CH-CH

R4 is C1-C4alkyl

R5, R6, R7, R8, R9 and R10 are for example hydrogen or C1-C4alkyl

and X is a x-valent cationic counter ion

are in particular suitable as photoinitiators for the curing with UV-A light (320-450 nm).

Priority: EP20070105642 Applic. Date: 2007-04-04; WO2008EP53458 Applic. Date: 2008-03-25

Inventor: DIETLIKER KURT [CH]; MURER PETER [CH]; HUESLER RINALDO [CH]; JUNG TUNJA [DE]


Application No.: US20100105007A1  Published: 29/Apr/2010

Title: Plate element for the manufacture of a dental prosthesis

Applicant/Assignee:

Application No.: 12/603997   Filing Date: 22/Oct/2009

Abstract:The curved plate is used to position and model a malleable material capable of temporarily supporting the incisor and pinless teeth according to positions and orientations that will then be fixed permanently in the prosthesis. The plate has a general U shape, delimited by two parabola-shaped contours: an outer edge and an inner edge, respectively corresponding to the contour of the vestibular walls of the incisor and pinless teeth of the prosthesis to be built. The plate features a flat surface on its lower face, and an appendix defining a visible reference point that must correspond to the position of the interincisive papilla. The distance between the reference point and an average central point of the outer edge indicating a position situated between the more vestibular walls of the upper central incisor teeth, is between 8 and 10 mm.

Priority: IT2008TO00780 Applic. Date: 2008-10-23

Inventor: PRETI GIULIO [IT]; BASSI FRANCESCO [IT]; GASSINO GIANFRANCO [IT]; NOTARO VINCENZO [IT]; GENTILE FRANCESCO [IT]


Application No.: US20100105618A1  Published: 29/Apr/2010

Title: Non-Natural Recombinant Gelatins with Enhanced Functionality

Applicant/Assignee:

Application No.: 12/528044   Filing Date: 21/Feb/2008

Abstract:The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins can be produced with enhanced stability.

Priority: EP20070102839 Applic. Date: 2007-02-21; EP20070102838 Applic. Date: 2007-02-21; EP20070116189 Applic. Date: 2007-09-12; EP20070116193 Applic. Date: 2007-09-12; EP20080100556 Applic. Date: 2008-01-16; WO2008NL50104 Applic. Date: 2008-02-21

Inventor: DE BOER ARJO LYSANDER [NL]; VAN URK HENDRIK [NL]; BOUWSTRA JAN BASTIAAN [NL]; VAN ASTEN PETER FRANCISCUS THE [NL]


Application No.: US20100105740A1  Published: 29/Apr/2010

Title: O-SUBSTITUTED-DIBENZYL UREA-DERIVATIVES AS TRPV1 RECEPTOR ANTAGONISTS

Applicant/Assignee: PHARMESTE S.R.L

Application No.: 12/519753   Filing Date: 06/Dec/2007

Abstract:The invention relates to compounds of formula (I) in which R is selected from halogen, alkyl, alkoxy, aryl and heteroaryl

R1 is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl, 1,3-dioxolane-ethyl, 1,3-dioxane-methyl, 1,3-dioxolane-methyl, 1,3-dioxane-ethyl, 3-fluoro-2-hydroxypropyl, 3-car-boxy-2-hydroxy-propyl, 3-chloro-2-hydroxypropyl, 2-hydroxypropyl, 2-hydroxy-propen-2-yl, morpholinoethyl, piperazinoethyl, hydroxymethyl, benzyl, 4-(hydroxymethyl)benzyl, 4-chlorobenzyl, 4-fluorobenzyl, and 4-hydroxybenzyl. R2 is te/t-butyl or trifluoromethyl

R3 is independently selected from hydrogen, carboxy, cyano, alkyl or hydroxyalkyl, The compounds of formula (I) can be used for the preparation of pharmaceutical compositions for the therapy of inflammatory states, such as chronic neuropathic pain, over-active bladder syndrome, tumor pain, haemorrhoids, inflammatory hyperalgesia, post-intervention pain, dental extraction, airway and gastro-intestinal diseases.

Priority: EP20060026533 Applic. Date: 2006-12-21; WO2007IB03784 Applic. Date: 2007-12-06

Inventor: BARALDI PIER GIOVANNI [IT]; BOREA PIER ANDREA [IT]; GEPPETTI PIERANGELO [IT]; FRUTTAROLO FRANCESCA [IT]; PAVANI MARIA GIOVANNA [IT]; TREVISANI MARCELLO [IT]


Application No.: US20100105802A1  Published: 29/Apr/2010

Title: CURABLE COMPOSITION FOR DENTAL PURPOSES

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/525323   Filing Date: 24/Jan/2008

Abstract:A curable composition for dental use, containing a polymerizable monomer, inorganic particles (A) having irregular shapes and an average particle size of from 1.0 to 5.0 [mu]m, wherein the inorganic particles (A) are surface-treated with a silane coupling agent (a) represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is a hydrolyzable group, R3 is a hydrocarbon group having 1 to 6 carbon atoms, X is an oxygen or sulfur atom, p is 2 or 3, and q is an integer of from 8 to 13, and inorganic particles (B) having irregular shapes and/or spherical or nearly spherical shapes, and an average particle size of from 0.01 to 0.10 [mu]m, wherein the inorganic particles (B) are surface-treated with a silane coupling agent (b) represented in the same manner as in the silane coupling agent (a) except that q in the formula (I) is an integer of from 1 to 6, wherein the inorganic particles (A) and the inorganic particles (B) are contained in amounts of from 85 to 98% by weight and from 2 to 15% by weight, respectively, of the entire amount of the inorganic particles. The curable composition for dental use of the present invention can be suitably used as a material capable of substituting a part or all of a natural tooth in the field of dental therapy.

Priority: JP20070023538 Applic. Date: 2007-02-01; WO2008JP51003 Applic. Date: 2008-01-24

Inventor: KUBOE YOSHIKO [JP]; SEKIGUCHI TAKAHIRO [JP]


Application No.: US20100107417A1  Published: 06/May/2010

Title: Eating utensil incorporating dental flosser

Applicant/Assignee:

Application No.: 12/231274   Filing Date: 02/Sep/2008

Abstract:An eating utensil such as a disposable plastic fork, spoon or knife, or combination thereof, is combined with a dental cleaning device such as a toothpick and/or a dental flosser for personal use after eating in a location where dental hygiene items may not be otherwise available. In some embodiments the dental cleaning device may be permanently attached to the eating utensil, which can serve as a handle for using the dental cleaning device

in other embodiments the dental cleaning device may be removed in a snap-off manner for convenient deployment independent of the eating utensil, optionally configured with a thumb-finger tab.

Priority: US20080133106P Applic. Date: 2008-06-25

Inventor: CRISP JACKSON L [US]


Application No.: US20100107419A1  Published: 06/May/2010

Title: Eating utensil incorporating oral cleaning facility

Applicant/Assignee:

Application No.: 12/592653   Filing Date: 01/Dec/2009

Abstract:An eating utensil such as a disposable plastic fork, spoon, knife, or combination thereof, is combined with at least one oral cleaning device such as a toothpick, interdental pick, brush, tongue cleaner and/or a dental flosser for personal use after eating in a location where oral cleaning facilities may not be otherwise available. In some embodiments the oral cleaning device may be permanently attached to the eating utensil, which can serve as a handle for using the oral cleaning device. In other embodiments the oral cleaning device may be displaced in a snap-off or bend-away manner at score lines to expose the oral cleaning device for use, either still attached to the utensil or removed for separate use, optionally configured with a thumb-finger grip tab.

Priority: US2008-231274 Applic. Date: 2008-09-02; US20080133106P Applic. Date: 2008-06-25

Inventor: CRISP JACKSON L [US]


Application No.: US20100109179A1  Published: 06/May/2010

Title: Orally Therapeutic Plastics and Devices Formed Therefrom

Applicant/Assignee: CAO GROUP, INC

Application No.: 12/684956   Filing Date: 10/Jan/2010

Abstract:The present invention provides methods whereby a thermally formable plastic is compounded with releasable active ingredients. The compounded plastic is then formed into a desired dental delivery device such as an anatomical membrane, tray or strip. The dental device is then placed in the oral environment where it will release or leach active ingredients. The dental device is intended to treat, alter, improve, or aid in various conditions that are often present in the oral environment.

Priority: US2006-381320 Applic. Date: 2006-05-02; US20050686336P Applic. Date: 2005-06-01

Inventor: JENSEN STEVEN D [US]


Application No.: US20100111879A1  Published: 06/May/2010

Title: SACCHARIDE FOAMABLE COMPOSITIONS

Applicant/Assignee: FOAMIX LTD

Application No.: 12/646322   Filing Date: 23/Dec/2009

Abstract:A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2006-430437 Applic. Date: 2006-05-09; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]


Application No.: US20100111880A1  Published: 06/May/2010

Title: NOVEL 1,3-OXATHIANE COMPOUNDS AND THEIR USE IN FLAVOR AND FRAGRANCE COMPOSITIONS

Applicant/Assignee:

Application No.: 12/261538   Filing Date: 30/Oct/2008

Abstract:The present invention relates to novel 1,3-oxathiane compounds represented by Formula I: wherein R is selected from the group consisting of ethyl, butyl, propyl, and (methylthio)ethyl, and their uses to enhance a flavor or fragrance composition.

Priority:

Inventor: CHEN ZHEN [US]; DEWIS MARK L [US]; MERRITT DEBRA [US]


Application No.: US20100111906A1  Published: 06/May/2010

Title: VOLUME MAINTAINING OSTEOINDUCTIVE/OSTEOCONDUCTIVE COMPOSITIONS

Applicant/Assignee:

Application No.: 12/548029   Filing Date: 26/Aug/2009

Abstract:An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.

Priority: US2005-284539 Applic. Date: 2005-11-22; US2003-413324 Applic. Date: 2003-04-14; WO2000US28462 Applic. Date: 2000-10-13; US19990159774P Applic. Date: 1999-10-15

Inventor: SCARBOROUGH NELSON L [US]; GADALETA SERGIO J [US]; KAES DAVID [US]; MANRIQUE ALBERT [US]


Application No.: US20100112015A1  Published: 06/May/2010

Title: Orally administered agent and an orally administered agent/supporting substrate complex

Applicant/Assignee: LINTEC CORPORATION

Application No.: 12/591700   Filing Date: 30/Nov/2009

Abstract:With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.

Priority: JP20010125804 Applic. Date: 2001-04-24; JP20040106854 Applic. Date: 2004-03-31; US2003-690811 Applic. Date: 2003-10-23; WO2002JP03920 Applic. Date: 2002-04-19; US2006-540952 Applic. Date: 2006-10-02; WO2005JP04569 Applic. Date: 2005-03-15

Inventor: NOGAMI EIJI [JP]


Application No.: US20100112050A1  Published: 06/May/2010

Title: Dosage Form For Insertion Into The Mouth

Applicant/Assignee:

Application No.: 12/608445   Filing Date: 29/Oct/2009

Abstract:Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.

Priority: US20080110775P Applic. Date: 2008-11-03

Inventor: RYOO JE PHIL [US]; CHU CHUN KWONG [HK]; WANG ZHENG [US]


Application No.: US20100112331A1  Published: 06/May/2010

Title: INFILTRATION GLASS CONTAINING NIOBIUM

Applicant/Assignee:

Application No.: 12/532279   Filing Date: 18/Mar/2008

Abstract:The present invention relates to an all-ceramic dental prosthesis in which a porous ceramic matrix material is infiltrated with a glass, having a solubility of <1100 [mu]g/cm2 according to DIN EN ISO 6872. The invention also relates to the use of niobium-containing glass having an Nb2O5 content of more than 0.1% by weight as an infiltration glass for all-ceramic dental compositions.

Priority: EP20070104702 Applic. Date: 2007-03-22; WO2008EP53247 Applic. Date: 2008-03-18

Inventor: STEPHAN MARC [DE]; DURSCHANG BERNHARD [DE]


Application No.: US20100112510A1  Published: 06/May/2010

Title: METHOD AND APPARATUS FOR BLEACHING TEETH

Applicant/Assignee:

Application No.: 12/685931   Filing Date: 12/Jan/2010

Abstract:A method and apparatus for whitening teeth which allow the user to undergo dental bleaching with the mouth closed and without protruding instruments, trays or electrical wires and the like. The apparatus includes a support structure and a dental whitening composition in contact with the support structure. A light source is included in the apparatus, disposed on or in the support structure so that light emitted from the source contacts on the dental whitening composition. The apparatus has a volume ranging between 0.5-450 cm3 permitting the apparatus to fit entirely within the mouth of a user during treatment.

Priority: US2002-309831 Applic. Date: 2002-12-04

Inventor: WASYLUCHA BRYAN [US]


Application No.: US20100112526A1  Published: 06/May/2010

Title: ARTICLE AND METHOD FOR CONTROLLING ORAL-ORIGINATED SYSTEMIC DISEASE

Applicant/Assignee:

Application No.: 12/264765   Filing Date: 04/Nov/2008

Abstract:Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent

removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue

administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria

and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy).

Priority:

Inventor: KELLER DUANE C [US]


Application No.: US20100113531A1  Published: 06/May/2010

Title: THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

Applicant/Assignee:

Application No.: 12/593095   Filing Date: 25/Mar/2008

Abstract:The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

Priority: WO2007IB51048 Applic. Date: 2007-03-26; WO2008IB50620 Applic. Date: 2008-02-21; WO2008IB51110 Applic. Date: 2008-03-25

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]


Application No.: US20100113576A1  Published: 06/May/2010

Title: Device and Method for Processing or Treating Surfaces By Means of A Dry Ice Granulate

Applicant/Assignee:

Application No.: 12/594598   Filing Date: 07/Apr/2008

Abstract:The invention relates to an apparatus for surface processing or surface treatment by means of dry ice granulate, with a reservoir for receiving a dry ice medium, in particular dry ice pellets, an inlet for the feed of a propellant medium, an outlet for the supply of a mixture of propellant medium and dry ice granulate to a blast gun, and an outflow chamber lying therebetween, there being arranged in the path between the reservoir and the outflow chamber a grinding mechanism, which is formed so as to comminute the dry ice medium to dry ice granulate with a particle size in a prescribed range, and a transport roll (4) being arranged between the grinding mechanism (3) and the outflow chamber (59), the transport roll (4) being operable with a variable speed so as to vary the quantity of the particles of the dry ice granulate per unit time. Furthermore, the invention relates to a corresponding method and the use of the method.

Priority: EP20070105772 Applic. Date: 2007-04-05; WO2008EP54151 Applic. Date: 2008-04-07

Inventor: RAEDER NIELS [DE]; ROTSTEIN ROSA [DE]


Application No.: US20100113643A1  Published: 06/May/2010

Title: CURATIVES FOR EPOXY ADHESIVE COMPOSITIONS

Applicant/Assignee: DESIGNER MOLECULES, INC

Application No.: 12/595505   Filing Date: 09/Apr/2008

Abstract:The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.

Priority: US20070922412P Applic. Date: 2007-04-09; US20070930166P Applic. Date: 2007-05-15; WO2008US59804 Applic. Date: 2008-04-09

Inventor: DERSHEM STEPHEN M [US]


Application No.: US20100116281A1  Published: 13/May/2010

Title: TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/267061   Filing Date: 07/Nov/2008

Abstract:A tobacco product incorporates at least one anthocyanin compound or derivative thereof. Anthocyanin compounds can be incorporated into the filter element or other components of a mouth end piece of a cigarette. The tobacco product also can have a smokeless form, and can be a smokeless tobacco product characterized as "snus

" and within that smokeless tobacco composition or formulation is incorporated anthocyanin compounds. Tobacco in green or yellow form can be cured by first placing that tobacco in intimate contact with at least one sugar and/or salt, and subjecting that tobacco to curing conditions.

Priority:

Inventor: MARSHALL JERRY WAYNE [US]; ADAMS SUSAN MARLENE [US]; LAWSON DARLENE MADELINE [US]; DUBE MICHAEL FRANCIS [US]


Application No.: US20100116287A1  Published: 13/May/2010

Title: System and apparatus for dental hygiene

Applicant/Assignee:

Application No.: 12/291444   Filing Date: 10/Nov/2008

Abstract:A method to clean the interproximal mesial and distal surfaces of a pair of adjacent teeth, as well as to clean the outer surfaces of the teeth.

Priority:

Inventor: COHEN YANEAV [US]


Application No.: US20100119400A1  Published: 13/May/2010

Title: HIGH NOBLE DENTAL ALLOY

Applicant/Assignee:

Application No.: 12/617381   Filing Date: 12/Nov/2009

Abstract:A silver free high noble dental alloy comprising at least 60 wt. % noble materials, where 40 wt. % of the material is gold

at least 2.5 wt. % gallium, at least about from 2 to 4 wt. % cobalt

and at least from about 0.01 to 0.25 wt. % lithium and/or boron

and a principal balance of palladium is provided. Dental products and methods of manufacturing dental products using such a high noble dental alloys are also provided.

Priority: US20080113917P Applic. Date: 2008-11-12

Inventor: PRASAD ARUN [US]; CASCONE PAUL J [US]


Application No.: US20100119492A1  Published: 13/May/2010

Title: Method and device for activating stem cells

Applicant/Assignee: SYNTHES USA, LLC

Application No.: 12/589956   Filing Date: 30/Oct/2009

Abstract:Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

Priority: US20090152335P Applic. Date: 2009-02-13; US20080110096P Applic. Date: 2008-10-31

Inventor: HANS MEREDITH [US]; BUECHTER DOUG [US]; GRUSKIN ELLIOTT [US]; HORNSBY STEPHEN [US]; BROWN MELISSA [US]


Application No.: US20100119574A1  Published: 13/May/2010

Title: Recombinant Gelatins

Applicant/Assignee:

Application No.: 12/527900   Filing Date: 21/Feb/2008

Abstract:The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.

Priority: EP20070102838 Applic. Date: 2007-02-21; EP20070102839 Applic. Date: 2007-02-21; EP20070116189 Applic. Date: 2007-09-12; EP20070116193 Applic. Date: 2007-09-12; EP20080100556 Applic. Date: 2008-01-16; WO2008NL50098 Applic. Date: 2008-02-21

Inventor: DE BOER ARJO LYSANDER [NL]; VAN URK HENDRIK [NL]; BOUWSTRA JAN BASTIAAN [NL]; VAN ASTEN PETER FRANCISCUS THE [NL]


Application No.: US20100119987A1  Published: 13/May/2010

Title: Method of Treating Residual Caries

Applicant/Assignee: CAO GROUP, INC

Application No.: 12/563223   Filing Date: 21/Sep/2009

Abstract:The present invention is a method of treating residual caries utilizing a matched laser and dye combination. After initial preparation and excavation of a caries site, a dye is flooded into the site which stains areas of residual caries. A laser with a complimentary wavelength is then used to ablate stained areas. Since healthy dental tissue will not receive the dye and allow staining, diseased tissue will be the only tissue that is stained, not only providing a visual indicator, but also providing a more efficient surface to receive laser energy and allow for more efficient ablation of the compromised tissue. According to the method, the dye may contain and enhancing, oxidizing compound or an anesthetic, and surrounding tissues may be protected by the use of substances opaque to the radiant energy. Indocyanine green has shown particular effectiveness as a dye in this and related methods.

Priority: US2007-759784 Applic. Date: 2007-06-07; US2006-423424 Applic. Date: 2006-06-09; US2009-555692 Applic. Date: 2009-09-08

Inventor: JENSEN STEVEN D [US]


Application No.: US20100120279A1  Published: 13/May/2010

Title: LAMP HOLDER

Applicant/Assignee:

Application No.: 12/689668   Filing Date: 19/Jan/2010

Abstract:A bipin fluorescent-lamp holder has a housing formed with an outwardly open housing mouth and a rotor rotatable in the housing adjacent the mouth about an axis and having a diametrally throughgoing rotor slot. The rotor is rotatable between an installation position with the rotor slot aligned with the slot and an angularly offset contact position with the slot not aligned with the mouth. The rotor and housing are so dimensioned as to receive the pins extending parallel to the axis and to move the pins in a circular orbit centered on the axis on rotation of the rotor in the housing, and contacts in the housing diametrally flanking the axis each having a main part lying outside the orbit and a contact part engageable into the orbit. The contacts pins are aligned with the slot and project into ends of the slot and into engagement with the pins only in the contact position of the rotor.

Priority: DE200710051431 Applic. Date: 2007-10-25; DE200710054930 Applic. Date: 2007-11-17; US2008-191806 Applic. Date: 2008-08-14

Inventor: VOGT KARL-WILHELM [DE]; GRESCHNER HARTMUT [DE]; NASSE MARKUS [DE]


Application No.: US20100120902A1  Published: 13/May/2010

Title: STANDARIZED BIOACTIVE HERBAL EXTRACTS

Applicant/Assignee: RANBAXY LABORATORIES LIMITED

Application No.: 12/532815   Filing Date: 24/Mar/2008

Abstract:The present invention relates to standardized extracts of Boerhaavia diffusa, wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers

processes for the isolation of the bioactive markers

processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa

pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.

Priority: IN2007DE00635 Applic. Date: 2007-03-23; IN2007DE01928 Applic. Date: 2007-09-11; WO2008IB51089 Applic. Date: 2008-03-24

Inventor: KATIYAR CHANDRA KANT [IN]; KANAUJIA ANIL [IN]; DUGGAR RAJEEV [IN]; YADAV SATYAPAL SINGH [IN]; SHARMA NAVIN [IN]; RAY ABHIJIT [IN]; SHIRUMALLA RAJKUMAR [IN]; BAJPAI MALINI [IN]; SHUKLA GYANESH [IN]; LAKSHMI BADDIREDDI SUBHADRA [IN]; VINAYKUMAR KONTHAM SANATHKUMAR [IN]


Application No.: US20100122709A1  Published: 20/May/2010

Title: CONFIGURABLE MULTIPURPOSE ACCESSORY KIT

Applicant/Assignee:

Application No.: 12/275140   Filing Date: 20/Nov/2008

Abstract:A configurable multipurpose accessory kit is provided. Such an accessory kit may include a central coupler, and a plurality of accessories which may be configured to meet the needs of a user. The central coupler may be a solid ring, hinged ring, split ring or linear. The accessories may then couple to the central coupler. The accessories may include an accessory coupler, and extender and a functional component. The accessory coupler may reversibly decouple from the central coupler. The extender is one of a chain, cable, string or rope. When the central coupler is a solid ring, the accessory couplers may include a clip enabled to couple and decouple from the central coupler. Where the central coupler includes a hinged ring or a split ring the accessory couplers may be solid. These accessory couplers may include a quick release for rapid removal of the accessory.

Priority:

Inventor: JANATPOUR NEDDA [US]; KUGIZAKI JENNY [US]


Application No.: US20100124560A1  Published: 20/May/2010

Title: MULTI PORTION INTRA-ORAL DOSAGE FORM AND USE THEREOF

Applicant/Assignee: MCNEIL AB

Application No.: 12/271094   Filing Date: 14/Nov/2008

Abstract:The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers/signals as conceptual aids for the subject. Also contemplated are a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N'-oxide, nornicotine, (S)-nicotine-N-[beta]-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.

Priority:

Inventor: HUGERTH ANDREAS [SE]; LINDELL KATARINA [SE]; NICKLASSON FREDRIK [SE]; THYRESSON KRISTINA [SE]; BUNICK FRANK [US]; LUBER JOSEPH [US]


Application No.: US20100125072A1  Published: 20/May/2010

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/650196   Filing Date: 30/Dec/2009

Abstract:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Priority: US2006-402310 Applic. Date: 2006-04-11; US20050670896P Applic. Date: 2005-04-11

Inventor: CHAFEEV MIKHAIL [CA]; CHAKKA NAGASREE [US]; CHOWDHURY SULTAN [CA]; FRASER ROBERT [CA]; FU JIANMIN [CA]; HOU DUANJIE [CA]; HSIEH TOM [CA]; KAMBOJ RAJENDER [CA]; LIU SHIFENG [CA]; RAINA VANDNA [IN]; BAGHERZADEH MEHRAN SEID [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]


Application No.: US20100125960A1  Published: 27/May/2010

Title: DEVICE FOR DENTAL AND/OR ORAL CARE AND METHOD FOR PRODUCING THE SAME

Applicant/Assignee:

Application No.: 12/597608   Filing Date: 28/Apr/2008

Abstract:The invention relates to a device for dental and/or oral care, especially a tooth brush, comprising a preferably rod-shaped tool support to which a cleaning tool, especially a bristle field, can be fastened. The tool support is configured as a composite body that comprises an enveloping body from a first material, preferably plastic material, and a functional body from a second material, preferably metal, which is embedded in the enveloping body. The dental and/or oral care device is characterized in that the functional body is configured in at least some sections thereof as a trelliswork girder frame that has longitudinal girders substantially extending in the longitudinal direction of the tool support and a plurality of cross-girders. The enveloping body is especially transparent so that the functional body is visible through the enveloping body.

Priority: DE200710019908 Applic. Date: 2007-04-27; WO2008EP03444 Applic. Date: 2008-04-28

Inventor: SCHAMBERG STEFAN [DE]; STOERKEL JENS [DE]; WINKLER TILMANN [DE]; VITT MARTIN [DE]; PFEIFER ULRICH [DE]


Application No.: US20100126515A1  Published: 27/May/2010

Title: Antimicrobial dental appliances

Applicant/Assignee: NEW MILLENNIUM ENTERPRISES, LLC

Application No.: 12/655542   Filing Date: 04/Jan/2010

Abstract:The present invention provides for a dental appliance, mouthguard and/or divers mouthpiece using an anti-microbial composition that combines the use of an elastomeric polymer composition with micronized or submicron sized particles of metal or organo/inorgano metal complexes. In addition, the use of an anti-microbial composition for use with a diver's air delivery hose to prevent breathing of contaminated air is also described.

Priority: US2006-601995 Applic. Date: 2006-11-20; US20060801653P Applic. Date: 2006-05-19

Inventor: MASON RICHARD [US]


Application No.: US20100126528A1  Published: 27/May/2010

Title: Confinement of Foam Delivered by a Proximity Head

Applicant/Assignee:

Application No.: 12/324316   Filing Date: 26/Nov/2008

Abstract:In an example embodiment, a linear wet system includes a carrier and a proximity head in a chamber. The proximity head includes three sections in a linear arrangement. The first section suctions liquid from the upper surface of a semiconductor wafer as the wafer is transported by the carrier under the proximity head. The second section is configured to cause a film (or meniscus) of cleaning foam which is a non-Newtonian fluid to flow onto the upper surface of the wafer. The third section is configured to cause a film of rinsing fluid to flow onto the upper surface of the wafer as the wafer is carried under the proximity head. The third section is defined partially around the second section and up to the first section, so that the third section and the first section create a confinement of the cleaning foam with respect to the chamber.

Priority:

Inventor: KHOLODENKO ARNOLD [US]; LIN CHENG-YU SEAN [US]; GINZBURG LEON [US]; MANDELBOYM MARK [US]; TOMASCH GREGOGRY A [US]; HUSAIN ANWAR [US]


Application No.: US20100126990A1  Published: 27/May/2010

Title: UPGRADED SINGLE-DOSE CONTAINER PARTICULARLY FOR FLUID PRODUCTS

Applicant/Assignee:

Application No.: 12/452501   Filing Date: 22/Oct/2007

Abstract:The upgraded single-dose container (1) particularly for fluid products comprises a hollow containment body (2) for a fluid product, a neck (3) that extends from the body having a dispensing mouth (4) for the product and closing means (8) that comprise a grip (9) supporting integral at least one shutter element of the dispensing mouth, a first threaded portion suitable for being associated with a second threaded portion (24) of the neck and a ring-shaped collar (11) arranged on the neck by interposing coupling means associable removable to the grip along pre-established breaking areas.

Priority: IT2007MO00239 Applic. Date: 2007-07-17; WO2007IB03163 Applic. Date: 2007-10-22

Inventor: FONTANA ANTONIO [IT]


Application No.: US20100129295A1  Published: 27/May/2010

Title: Compositions for preventing and/or treating gingivitis

Applicant/Assignee:

Application No.: 12/313678   Filing Date: 22/Nov/2008

Abstract:Compositions and methods for preventing and/or treating gingivitis which include the use of one or a plurality of TNF-[alpha] modulators.

Priority:

Inventor: SHAW JIAJIU [US]; WANG JEN CHUAN [US]; GZYBOWSKI MICHAEL S [US]


Application No.: US20100129296A1  Published: 27/May/2010

Title: EXTRACT OF TRIGONELLA FOENUM-GRAECUM

Applicant/Assignee: V-BIOTEK HOLDING APS

Application No.: 12/595715   Filing Date: 14/Apr/2008

Abstract:Disclosed herein is an extract obtainable from Trigonella foenum-graecum. In particular, the extract is obtainable by a process comprising the steps of preparing a mixture of a plant material obtained from Trigonella foenum-graecum and liquid, incubating said mixture for at least 3 hours, heating of said mixture, and recovering a liquid extract from mixture. The extract is useful in the manufacture of various types of compositions, such as pharmaceutical compositions, disinfectant or preservation agents. The pharmaceutical may be used for the treatment or prevention of an inflammatory disease or an infectious condition.

Priority: US20070911653P Applic. Date: 2007-04-13; WO2008DK50086 Applic. Date: 2008-04-14

Inventor: OLSEN JENS STEEN [DK]


Application No.: US20100129297A1  Published: 27/May/2010

Title: USE OF AN AQUEOUS GRAPE SEED EXTRACT COMBINED WITH AT LEAST ONE FLUORINE SALT TO COMBAT THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND COMPOSITIONS COMPRISING SAID COMBINATION

Applicant/Assignee:

Application No.: 12/597114   Filing Date: 24/Apr/2008

Abstract:The invention relates to the use of an aqueous grape seed extract combined with at least one fluorine salt for the preparation of an oral hygiene composition intended to prevent and/or reduce the formation and accumulation of dental biofilm on dental surfaces or on gingival epithelial tissue.

Priority: FR20070054670 Applic. Date: 2007-04-24; WO2008EP55032 Applic. Date: 2008-04-24

Inventor: VEZIN JEAN-CLAUDE [FR]


Application No.: US20100129298A1  Published: 27/May/2010

Title: Recalcification Promoter And Composition For Oral Cavity

Applicant/Assignee: KABUSHIKI KAISHA SANGI

Application No.: 12/594230   Filing Date: 08/Apr/2008

Abstract:It is intended to provide a remineralization promoter for tooth enamel and a composition for an oral cavity, which can highly effectively promote the remineralization of tooth enamel and strongly inhibit dental caries. The remineralization promoter for tooth enamel and the composition for an oral cavity are characterized by containing amorphous hydroxyapatite and/or amorphized hydroxyapatite showing two peaks at 2[theta]=31 to 35 DEG in X-ray diffraction. The amorphized hydroxyapatite is obtained by reacting calcium salt with phosphate in an aqueous solution and drying the reaction solution at a temperature of 10 to 70 DEG C.

Priority: JP20070103135 Applic. Date: 2007-04-10; WO2008JP00909 Applic. Date: 2008-04-08

Inventor: SAKUMA SHUJI [JP]; ISHIZAKI TSUTOMU [JP]; ARAKAWA TADAYOSHI [JP]


Application No.: US20100129342A1  Published: 27/May/2010

Title: Human Growth and Differentiation Factor GDF-5

Applicant/Assignee:

Application No.: 12/374080   Filing Date: 17/Jul/2007

Abstract:This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. Said compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as for example growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The invention can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.

Priority: EP20060014928 Applic. Date: 2006-07-18; WO2007EP06331 Applic. Date: 2007-07-17

Inventor: POHL JENS [DE]; PLOEGER FRANK [DE]


Application No.: US20100129357A1  Published: 27/May/2010

Title: ANTIBODIES TO IL-6 AND USE THEREOF

Applicant/Assignee:

Application No.: 12/502581   Filing Date: 14/Jul/2009

Abstract:The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other cogulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

Priority: US20080117861P Applic. Date: 2008-11-25; US20080117839P Applic. Date: 2008-11-25; US20080117811P Applic. Date: 2008-11-25

Inventor: GARCIA-MARTINEZ LEON [US]; JENSEN ANN ELISABETH CARVALHO [US]; OLSON KATIE [US]; DUTZAR BEN [US]; OJALA ETHAN [US]; KOVACEVICH BRIAN [US]; LATHAM JOHN [US]; SMITH JEFFREY T L [US]


Application No.: US20100129402A1  Published: 27/May/2010

Title: DOUBLE-EFFECTIVE VACCINE VECTOR AGAINST FOOT-AND-MOUTH DISEASE VIRUS (FMDV), METHODS OF PREPARING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/577900   Filing Date: 13/Oct/2009

Abstract:A double-effective vaccine vector against foot-and-mouth disease virus having a bicistronic expression vector sequence, the bicistronic expression vector sequence is an antisense gene sequence capable of conjugating with 5' UTR of RNA of the foot-and-mouth disease virus genome and an intact sequence of VP1 structural protein gene of the foot-and-mouth disease virus. Animal experiments show that the vaccine vector provides double effects in terms of gene therapy and gene immunization for the prevention and treatment of foot-and-mouth disease in animals. Also provided are construction methods and methods of use of the vaccine vector.

Priority: CN20071103083 Applic. Date: 2007-05-28; WO2008CN00563 Applic. Date: 2008-03-21

Inventor: LIU JIXING [CN]; YANG BIN [CN]; LAN XI [CN]; YIN XIANGPING [CN]; BAI YINMEI [CN]; HAN XIAORONG [CN]; LI XUERUI [CN]; LI BAOYU [CN]; FANG YUPING [CN]; LI ZHIYONG [CN]


Application No.: US20100130441A1  Published: 27/May/2010

Title: USE OF VITAMIN B12 FOR TREATMENT OF MUCOSAL LESIONS

Applicant/Assignee:

Application No.: 12/618379   Filing Date: 13/Nov/2009

Abstract:The present invention relates to the use of the nutrition supplement known as vitamin B12 (cobalamin) to treat or prevent mucosal lesions. It relates particularly to treatment of mucosal lesions and prevention of development of recurrent mucosal lesions by the repeated administration over a period of time of vitamin B12 where a subject has normal, or above normal, serum vitamin B12 levels. Compositions (medicaments), including friendly carriers (e.g. chewing gum), and kits, for vitamin B12 delivery to mucosal lesions or other injuries are also provided.

Priority: IL20070183171 Applic. Date: 2007-05-14; WO2008IB03376 Applic. Date: 2008-05-14

Inventor: RUDOY INNA [IL]; VOLKOV ILIA [IL]; PRESS YAN [IL]


Application No.: US20100130445A1  Published: 27/May/2010

Title: FILM FORMING DENTAL COMPOSITIONS AND RELATED METHODS

Applicant/Assignee:

Application No.: 12/594988   Filing Date: 10/Jul/2008

Abstract:Film forming dental compositions are provided comprising a compound of the formula or a pharmaceutically acceptable salt thereof, and a binder.

Priority: US20070951758P Applic. Date: 2007-07-25; WO2008US69628 Applic. Date: 2008-07-10

Inventor: YANG JIE [US]; VELAMAKANNI BHASKAR V [US]; MITRA SIMITA B [US]; POCIUS ALPHONSUS V [US]; STOFKO JR JOHN J [US]; YARWOOD JEREMY M [US]


Application No.: US20100130487A1  Published: 27/May/2010

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/650218   Filing Date: 30/Dec/2009

Abstract:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Priority: US2006-402310 Applic. Date: 2006-04-11; US20050670896P Applic. Date: 2005-04-11

Inventor: CHAFEEV MIKHAIL [US]; CHAKKA NAGASREE [US]; CHOWDHURY SULTAN [US]; FRASER ROBERT [US]; FU JIANMIN [CA]; HOU DUANJIE [US]; HSIEH TOM [US]; KAMBOJ RAJENDER [US]; LIU SHIFENG [CA]; RAINA VANDNA [US]; BAGHERZADEH MEHRAN SEID [US]; SUN JIANYU [US]; SUN SHAOYI [US]; SVIRIDOV SERGUEI [US]


Application No.: US20100130622A1  Published: 27/May/2010

Title: PHARMACEUTICAL PREPARATION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASE, AGENT FOR ORAL HYGIENE COMPRISING THEREOF, AND FOOD COMPRISING THEREOF

Applicant/Assignee:

Application No.: 12/275643   Filing Date: 21/Nov/2008

Abstract:The present invention provides a pharmaceutical composition for preventing and/or treating periodontal disease comprising at least one having dental root-periodontal tissue formation promotion effect selected from the group consisting of a compound shown in a following formula (I). (In the formula, R1 and R2 are independently functional groups selected from a group consisting of a substituted or non-substituted group of a linear alkyl group, a branched alkyl group, a linear alkenyl group and a branched alkenyl group with having the carbon number of 3 to 5. R'1 and R'2 are independently a hydrogen atom, hydroxyl group, or alkoxy group having the carbon number of 1 to 3.)

Priority:

Inventor: WOO JE-TAE [JP]; OHTA MASATO [JP]; YONEZAWA TAKAYUKI [JP]; TERUYA TOSHIAKI [JP]; CHA BYUNG-YOON [JP]; NAGAI KAZUO [JP]


Application No.: US20100130635A1  Published: 27/May/2010

Title: Dental adhesive composition

Applicant/Assignee:

Application No.: 12/460944   Filing Date: 27/Jul/2009

Abstract:Dental adhesive composition comprising (a) a polymerisable monomer or prepolymer, and (b) a solvent comprising t-butanol.

Priority: US2005-572613 Applic. Date: 2005-05-13; WO2005EP05263 Applic. Date: 2005-05-13; EP20040017749 Applic. Date: 2004-07-27

Inventor: BLACKWELL GORDON B [DE]


Application No.: US20100130637A1  Published: 27/May/2010

Title: Self-dental adhesive composition

Applicant/Assignee:

Application No.: 12/462609   Filing Date: 06/Aug/2009

Abstract:Self-adhesive dental restorative composition comprising (i) 10 to 40 percent by weight based on the total weight of the composition of a mixture of hydrolysis-stable polymerizable monomers of the following formula (I): wherein R is a m+n valent organic group having 1 to 20 carbon atoms and optionally 1 to 5 atoms selected from the group of nitrogen, oxygen and sulfur atoms

A independently represents a moiety of the following formula (II): wherein L is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group or a group of the following formula (III) wherein R' is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C6-14 aryl group

X is O, S, NH or NR'' wherein R'' is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group

a is 0 or 1

M is a group of the following formula (IV) wherein Y is O, S, NH or NR''' wherein R''' is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group

b is an integer of from O to 3

c is O or 1

d is an integer of from O to 3

provided that when b is O, then Y cannot be O

x is 0 or 1

y is 0 or 1

provided that x and y cannot be both 1, and provided that x cannot be 1 when L or a group of formula (III) is a hydrogen atom, and provided that when x is 0 then a is also 0, and provided that when y is 0 then b is greater than 0 or c is 0

B independently represents an acidic group

m is an integer of from 1 to 5

n is an integer of 0 to 3

and m+n is at least 2

(ii) 60 to 90 percent by weight based on the total weight of the composition of a filler

and (iii) an initiator system

wherein the portion of monomers of formula (I) wherein n is greater than 0 is at least 1 percent by weight based on the total weight of the mixture.

Priority: WO2008EP00916 Applic. Date: 2008-02-06; EP20070002662 Applic. Date: 2007-02-07

Inventor: KLEE JOACHIM [DE]; LEHMANN UWE [DE]; GLANER ANJA [DE]


Application No.: US20100130682A1  Published: 27/May/2010

Title: POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION, AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523554   Filing Date: 16/Jan/2008

Abstract:The present invention provides a polymerizable composition that exhibits excellent adhesive properties to a tooth structure (particularly dentin) when applied as a dental material, and a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a polymerizable monomer (A) that is a compound having at least two polymerizable groups. The polymerizable monomer (A) has a retention time of 7 minutes to 30 minutes in a high-performance liquid chromatography (HPLC) measurement conducted under a condition in which a column with an inner diameter of 3.9 mm and a length of 300 mm, packed with a C18 packing material having been crushed to have an average particle size of 10 [mu]m and a pore size of 125 angstroms, is used, an eluent is a mixed solvent of methanol and water contained at a ratio of 3:7, a flow rate is 1.0 mL/minute, a measurement temperature is 50 DEG C., a sample injection volume is 10 [mu]L, and a dead volume from a sample inlet to a detection point excluding the column is 87 [mu]L. The present invention also is a composition containing the polymerizable monomer (A).

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50435 Applic. Date: 2008-01-16

Inventor: HINAMOTO AI [JP]; ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; TAKEI MITSURU [JP]; NISHIGAKI NAOKI [JP]


Application No.: US20100132173A1  Published: 03/Jun/2010

Title: SYSTEM AND METHOD FOR REDUCING ENVIRONMENTAL CREMATORIAL RELEASE OF MERCURY FROM MERCURY-CONTAINING DENTAL AMALGAM

Applicant/Assignee:

Application No.: 12/625176   Filing Date: 24/Nov/2009

Abstract:The invention described herein provides for a simple, economical system and method for reducing environmental release of dental amalgamous mercury from teeth caused by cremation of corpses. The invention controls and reduces the amount of mercury released using a pre-crematorial and non-disfiguring system and method. The system of the invention can include a dental containment and applicator delivery system to apply a curable thermal protectant composition onto the teeth. The composition coating significantly inhibits the extent of thermal destruction of the tooth per se including its amalgam filling content.

Priority: US20080117277P Applic. Date: 2008-11-24; US20090174593P Applic. Date: 2009-05-01

Inventor: ARCAND BENJAMIN [US]; ROLFES BRYAN N [US]; MURDESHWAR NIKHIL M [US]; HALE JOSEPH E [US]; JOHNSON STEVEN M [US]; MITLYNG LUKE A [US]; MULLENBACH JOSEPH [US]; KAPPHAHN KRISTOPHER I [US]


Application No.: US20100132720A1  Published: 03/Jun/2010

Title: Oral Cavity Manipulator

Applicant/Assignee:

Application No.: 12/664391   Filing Date: 16/Jun/2008

Abstract:An oral cavity manipulator for controlling the position of tongue and jaw, the manipulator including a foundation body, maxilla and mandibular teeth engaging elements mountable on the foundation body and having width equal to or greater than the width of the foundation body and including teeth receiving portions for in use receiving the teeth of the user, a tongue position means attached to one of the foundation body, or the teeth engaging elements wherein in an operating condition the mandibular teeth engaging element is selectively located on the foundation body forward of the maxilla teeth engaging element to receive and locate the mandible of a user forward of the maxilla and position the tongue between the teeth elements to substantially maintain unobstructed airways at the throat of the user.

Priority: AU20070202799 Applic. Date: 2007-06-15; WO2008AU00846 Applic. Date: 2008-06-16

Inventor: RAZMOVSKI JOHN [AU]


Application No.: US20100133117A1  Published: 03/Jun/2010

Title: METHODS FOR ELECTROCHEMICAL DETECTION/QUANTIFICATION OF A NUCLEIC ACID

Applicant/Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Application No.: 12/376782   Filing Date: 08/Aug/2006

Abstract:The invention provides methods and kits for the electrochemical detection and/or quantification of a target nucleic acid molecule by means of a detection electrode. In one method there is immobilized on the detection electrode a peptide nucleic acid (PNA) capture molecule, which has a nucleotide sequence that is at least partially complementary to at least a portion of the target nucleic acid molecule. The electrode is contacted with a solution expected to include the target nucleic acid molecule and the target nucleic acid molecule allowed to hybridize to the PNA, thereby allowing the formation of a complex between the PNA capture molecule and the target nucleic acid molecule. A polymerisable positively chargeable precursor is added, which associates to the complex formed between the PNA capture molecule and the target nucleic acid molecule. A suitable reactant molecule is added, initiating the polymerisation of the polymerisable positively chargeable precursor and the formation of an electroconductive polymer. An electrochemical measurement at the detection electrode is performed. In another method a nucleic acid capture molecule is immobilized on the electrode. In this method a polymerisable positively chargeable precursor, a suitable substrate molecule, and an enzyme attached to a detection probe nucleic acid molecule are used. The detection probe nucleic acid molecule is at least partially complementary to at least a portion of the target nucleic acid molecule. The detection probe hybridizes to a portion of the target nucleic acid that is different from the portion to which the capture nucleic acid molecule hybridises.

Priority: WO2006SG00226 Applic. Date: 2006-08-08

Inventor: GAO ZHIQIANG [SG]


Application No.: US20100133711A1  Published: 03/Jun/2010

Title: METHOD OF FORMING A DENTAL ARTICLE

Applicant/Assignee: IVOCLAR VIVADENT AG

Application No.: 12/694710   Filing Date: 12/Feb/2010

Abstract:A method of making a dental article including a pressable body possessing a flexural strength of at least 125 MPa and flowable at about 850 DEG C. to about 950 DEG C. The body is composed of at least a glass matrix phase having a composition comprising Li2O and MgO.

Priority: US2007-785042 Applic. Date: 2007-04-13

Inventor: BRODKIN DMITRI G [US]; VERANO ANNA B [US]


Application No.: US20100135919A1  Published: 03/Jun/2010

Title: PROTEOLYTIC ENZYME FORMULATIONS

Applicant/Assignee:

Application No.: 12/376964   Filing Date: 09/Aug/2007

Abstract:Preferred embodiments of the present invention relate to proteolytic enzyme formulations. More specifically, several embodiments relate a proteolytic formulation comprising fungal protease, papain, bromelain, fungal pancreatin, nattokinase, protease-S, amylase, lipase, rutin, ginger, and CMIK-pH, to facilitate digestion, metabolism, degradation of target compounds, and systemic enzymatic action.

Priority: US20060836824P Applic. Date: 2006-08-10; WO2007US75630 Applic. Date: 2007-08-09

Inventor: BARRON JON [US]


Application No.: US20100135920A1  Published: 03/Jun/2010

Title: METHOD TO TREAT PROPOLIS

Applicant/Assignee: BALLOT-FLURIN APICULTEURS

Application No.: 12/595149   Filing Date: 23/Apr/2008

Abstract:A method to treat propolis includes conducting at least one first extraction of propolis performed on a batch of raw propolis with a first pure solvent to obtain a first extract having first properties. A second extraction may be performed with a second different pure solvent on the filtration residues obtained after the first extraction, so as to collect and make usable the entirety of the components of propolis using organic solvents only

and finally the method may include a third extraction following after the second extraction, performed on the filtration residues obtained after this second extraction, using a third pure solvent different from the two others

the first solvent then being water, the second being alcohol and the third being oil. The method applies to the production of extracts of propolis for use in the manufacture of hygiene, care, cosmetic products, food products and food supplements.

Priority: FR20070054648 Applic. Date: 2007-04-24; WO2008FR50736 Applic. Date: 2008-04-23

Inventor: BALLOT-FLURIN CATHERINE [FR]


Application No.: US20100135924A1  Published: 03/Jun/2010

Title: Oral Care Compositions Comprising Fused Silica

Applicant/Assignee:

Application No.: 12/625164   Filing Date: 24/Nov/2009

Abstract:An oral care composition comprising a fused silica abrasive and an orally-acceptable carrier.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: DECKNER GEORGE ENDEL [US]; BAIG ARIF ALI [US]; HUGHES IAIN ALLAN [US]; HAUGHT JOHN CHRISTIAN [US]


Application No.: US20100135925A1  Published: 03/Jun/2010

Title: Prophy Paste and Weekly Oral Care Compositions

Applicant/Assignee:

Application No.: 12/625223   Filing Date: 24/Nov/2009

Abstract:An oral care composition comprising a fused silica abrasive, wherein the fused silica has a median particle size of at least about 7 microns and wherein the composition has a PCR of at least about 100.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: HAUGHT JOHN CHRISTIAN [US]; DECKNER GEORGE ENDEL [US]; BAIG ARIF ALI [US]; HUGHES IAIN ALLAN [US]


Application No.: US20100135926A1  Published: 03/Jun/2010

Title: ANTIMICROBIAL AND IMMUNOSTIMULATORY SYSTEM COMPRISING AN OXIDOREDUCTASE ENZYME

Applicant/Assignee:

Application No.: 12/444231   Filing Date: 05/Oct/2007

Abstract:The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition

the system has a pH from approximately 4 to 8

and the system provides a two-stage hydrogen peroxide release.

Priority: GB20060019786 Applic. Date: 2006-10-06; WO2007IE00094 Applic. Date: 2007-10-05

Inventor: BARRETT JOHN REGINALD [IE]; BRENNAN JAMES JOSEPH [IE]; PATTON THOMAS PATRICK [IE]


Application No.: US20100135927A1  Published: 03/Jun/2010

Title: Mild Oral Care Compositions

Applicant/Assignee:

Application No.: 12/624680   Filing Date: 24/Nov/2009

Abstract:Oral compositions comprising fused silica, wherein the composition is essentially free of sodium lauryl sulfate.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: HUGHES IAIN ALLAN [US]; BAIG ARIF ALI [US]; DECKNER GEORGE ENDEL [US]


Application No.: US20100136498A1  Published: 03/Jun/2010

Title: Mouthpiece Devices and Methods to Allow UV Whitening of Teeth

Applicant/Assignee: TWILIGHT TEETH, INC

Application No.: 12/623939   Filing Date: 23/Nov/2009

Abstract:A plastic mouthpiece insert for allowing a wearer to whiten their teeth while getting a suntan, and have a generally oblong oval-rectangular opening with a curved rear end that abuts against the root surfaces of the frontal upper and lower teeth of the wearer. A raised front edge can protect the lips and separate in place about the opening to the mouthpiece. Whitening agents can be used to enhance the whitening effect so that ultraviolet light and heat source such as the sun or a sunlamp is all that it is needed. Reflective inner walls in the mouthpiece can magnify light to the teeth. The mouthpiece can include bite tables, and the side walls of the mouthpiece can be inwardly flared and funnel shaped for focusing and magnifying incoming light and heat. The mouthpiece can be colored to protect the inside of the wearer's mouth from receiving any light. An attachable *and detachable compact hands-free light source can also be used. The light source can clip on the front of the mouthguard so that the mouthguard can allow for teeth whitening without the need for a suntanning lamp or use of the sun or other exterior light sources. The attached light source allows the user to use the mouthguard and not be restricted to staying in one place. With the attached light source the user is free to use both their hands and do all other types of activities and be able to freely move around.

Priority: US2006-603301 Applic. Date: 2006-11-21; US2003-668726 Applic. Date: 2003-09-23; US20020413049P Applic. Date: 2002-09-24

Inventor: BAUGHMAN JERALD L [US]


Application No.: US20100136657A1  Published: 03/Jun/2010

Title: METHOD FOR STORING SILICA-BASED MATERIAL, PACKAGE PRODUCED WITH THE METHOD AND USE OF PACKAGE FOR PACKAGING OF SILICA-BASED PRODUCTS

Applicant/Assignee:

Application No.: 12/301195   Filing Date: 23/May/2007

Abstract:A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.

Priority: FI20060000698 Applic. Date: 2006-07-24; US20060802506P Applic. Date: 2006-05-23; WO2007FI00136 Applic. Date: 2007-05-23

Inventor: JOKINEN MIKA [FI]; KOSKINEN MIKA [FI]; JALONEN HARRY [FI]


Application No.: US20100137291A1  Published: 03/Jun/2010

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636316   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGA RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]


Application No.: US20100137299A1  Published: 03/Jun/2010

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/578148   Filing Date: 13/Oct/2009

Abstract:This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof

or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Priority: US20080106464P Applic. Date: 2008-10-17

Inventor: CHAFEEV MIKHAIL [CA]; CHOWDHURY SULTAN [CA]; FRASER LAUREN [CA]; FU JIANMIN [CA]; LANGILLE JONATHAN [US]; LIU SHIFENG [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]; WOOD MARK [CA]; ZENOVA ALLA [CA]; JIA QI [CA]; CADIEUX JEAN-JACQUES [CA]; GAUTHIER SIMON J [CA]; DOUGLAS AMY FRANCES [CA]; HSIEH TOM [CA]; CHAKKA NAGASREE [US]; CIKOJEVIC ZORAN [CA]


Application No.: US20100137338A1  Published: 03/Jun/2010

Title: INHIBITORS OF Akt ACTIVITY

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION

Application No.: 12/593415   Filing Date: 28/Mar/2008

Abstract:Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Priority: US20070908741P Applic. Date: 2007-03-29; WO2008US58603 Applic. Date: 2008-03-28

Inventor: SEEFELD MARK ANDREW [US]


Application No.: US20100137468A1  Published: 03/Jun/2010

Title: DENTAL COMPOSITION BASED ON SILICONE CROSSLINKABLE BY CATION PROCESS

Applicant/Assignee: BLUESTAR SILICONES FRANCE

Application No.: 12/644347   Filing Date: 22/Dec/2009

Abstract:The invention concerns dental compositions. Said composition comprises (1) a silicone crosslinkable and/or polymerizable by cation process

(2) an efficient amount of at least an initiator such as onium borate

(3) at least a photosensitizer

and (4) a dental filler present in the composition in a proportion of at least 10 wt. % relative to the composition total weight. Said dental compositions are useful for making dental prostheses or for dental restoration.

Priority: FR19980012375 Applic. Date: 1998-10-02; US2006-604510 Applic. Date: 2006-11-27; US2004-781064 Applic. Date: 2004-02-18; US2001-806629 Applic. Date: 2001-06-25; WO1999FR02345 Applic. Date: 1999-10-01

Inventor: FRANCES JEAN-MARC [FR]


Application No.: US20100137811A1  Published: 03/Jun/2010

Title: CELL HANDLING DEVICE, TISSUE REGENERATION COMPOSITION, AND TISSUE REGENERATION METHOD

Applicant/Assignee:

Application No.: 12/705252   Filing Date: 12/Feb/2010

Abstract:A syringe-type cell handling device for storing and subsequently transplanting, into a living body, cells harvested from a living body or cells obtained by culturing harvested cells. The syringe-type cell handling device includes a vessel having a closed mouth and being at least partially composed of a main body, and a plunger that is slidably insertable into the main body such that the handling medium can be transplanted into a living body by applying a pushing force to the plunger. At least a part of the device that contacts the fluid handling medium, when the vessel holds the handling medium, is a gas permeable region for passing a quantity of gas necessary for survival of the cells. It is preferable that at least a part of the storage vessel inner wall in contact with the cells is formed from a cell non-adhesive material.

Priority: JP20030359935 Applic. Date: 2003-10-20; JP20030359936 Applic. Date: 2003-10-20; US2006-574816 Applic. Date: 2006-04-06; WO2003JP16397 Applic. Date: 2003-12-19

Inventor: YUGE RUI [JP]; MATSUURA YOJI [JP]; SAJIKI TOSHINOBU [JP]


Application No.: US20100139022A1  Published: 10/Jun/2010

Title: Tooth rag

Applicant/Assignee:

Application No.: 12/460973   Filing Date: 08/Sep/2009

Abstract:The Tooth Rag is specially designed to be used with a standard, electronic or an all wooden tooth brush handle on a circular or rectangular platform or an all disposable wooden handle. Encompassing the underside of the unit would be a tab and a strip of self affixing Velcro material with a distal end of the device serving as a platform for the tooth rag. As such, the surface of this platform would be covered in corresponding fasteners which work in tandem with the Velcro found on the underside of the cleansing cloth.

Priority: US20080189986P Applic. Date: 2008-08-25

Inventor: HASSAN LOOKMAN I [US]


Application No.: US20100139524A1  Published: 10/Jun/2010

Title: Novel amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof

Applicant/Assignee: TAIPEI MEDICAL UNIVERSITY

Application No.: 12/591764   Filing Date: 01/Dec/2009

Abstract:A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: M 2 + &#xE89E

A x - &#xE89E

B 2 - x - ( I ) M 2 + &#xE89E

A y 2 - &#xE89E

C ( 4 - y ) 4 2 - ( II ) M 2 + &#xE89E

A z 3 - &#xE89E

D ( 6 - z ) 9 3 - ( III ) wherein, M2+, A-, B-, C-2, D-3, x, y, and z are defined the same as the specification. A novel tooth filling material comprises: a Portland cement, a bone substitute substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). In addition, a novel root canal filling material comprises: a Portland cement, a radiopaque substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). This amorphous divalent metal ion salt in the filling material of the present invention can improve the sticking together and reduce the setting time, thus offering more convenient in dental applications.

Priority: TW20080147977 Applic. Date: 2008-12-10

Inventor: YANG JENG-CHANG [TW]; LEE PEI-YING [TW]; JI DAIN-YU [TW]; TENG NAIN-CHIA [TW]; HSIEH SUNG-CHIH [TW]; LEE SHENG-YANG [TW]


Application No.: US20100139670A1  Published: 10/Jun/2010

Title: INTEROCCLUSAL APPLIANCE AND METHOD

Applicant/Assignee: HAYLOFT ENTERPRISES, INC

Application No.: 12/693568   Filing Date: 26/Jan/2010

Abstract:An interocclusal appliance is formed from a single polymer material composition as one unitary piece or from multiple polymer material compositions as a two-piece preform. The two-piece preform includes a base material and an impression material that has a softening point lower than the base material. Teeth are received into the heat-softened impression material, so as to contour the impression material. A portion of the impression material also may contour to a portion of the user's palate. In certain embodiments, substantially no polymeric material contacts the front surfaces of the front teeth, leading to greater comfort and better air flow between front teeth. In still another embodiment, the appliance fits over front teeth only and no polymeric material contacts the maxillary molars.

Priority: US2007-757490 Applic. Date: 2007-06-04

Inventor: LESNIAK FRANK M [US]


Application No.: US20100139689A1  Published: 10/Jun/2010

Title: Electrically powered dental flossing device with sanitary and disposable floss containing unit

Applicant/Assignee:

Application No.: 12/315889   Filing Date: 08/Dec/2008

Abstract:A device for flossing teeth includes a base unit defining a handle and a disposable head unit that removeably attaches to a top end of the base unit. An electric motor in the base unit, powered by a rechargeable battery, rotates a shaft upon operation of a switch. A pair of hollow tubular arm members extend from a top of the head unit and terminate at opposing open distal ends to define a gap therebetween. A predetermined length of dental floss is partially wound on a first wheel within a clean floss chamber of the head unit and extends through the arm members and across the gap without contacting the distal ends, thereby preventing the transfer of plaque, food particles and bacteria onto exposed surfaces of the arm members. Used floss is wound onto a second floss wheel in a segregated floss collection chamber. The shaft drivingly engages a gear assembly within the head unit for rotating the first and second floss wheels, thereby controlling advanced movement of the floss in order to provide clean floss across the gap, while isolating contaminated floss within the segregated floss collection chamber.

Priority:

Inventor: COUCH VICTOR [US]


Application No.: US20100143270A1  Published: 10/Jun/2010

Title: THERAPEUTIC COTININE COMPOSITIONS

Applicant/Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUBDATION

Application No.: 12/528050   Filing Date: 21/Feb/2008

Abstract:The present invention provides methods and compositions for treating acute and/or chronic inflammation with cotinine or a pharmaceutically acceptable salt thereof.

Priority: US20070890954P Applic. Date: 2007-02-21; WO2008US54569 Applic. Date: 2008-02-21

Inventor: SCOTT DAVID ALBERT [US]; MARTIN MICHAEL [US]


Application No.: US20100143294A1  Published: 10/Jun/2010

Title: ANTAGONISTS OF IL-6 TO PREVENT OR TREAT THROMBOSIS

Applicant/Assignee:

Application No.: 12/624830   Filing Date: 24/Nov/2009

Abstract:The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.

Priority: WO2008US64414 Applic. Date: 2008-05-21; WO2008US64432 Applic. Date: 2008-05-21; US2009-502581 Applic. Date: 2009-07-14; US2009-399156 Applic. Date: 2009-03-06; US2009-391717 Applic. Date: 2009-02-24; US2009-366567 Applic. Date: 2009-02-05; US20080117861P Applic. Date: 2008-11-25; US20080117839P Applic. Date: 2008-11-25; US20080117811P Applic. Date: 2008-11-25

Inventor: SMITH JEFFREY T L [US]


Application No.: US20100143329A1  Published: 10/Jun/2010

Title: REIMMUNIZATION AND ANTIBODY DESIGN

Applicant/Assignee:

Application No.: 12/299670   Filing Date: 12/Jan/2007

Abstract:The present invention relates to methods for harvesting of antibodies from an antibody library. The antibodies are harvested by utilising a certain epitope that is analogous to the epitope of the antigen used for immunization but that may differ in global physical and biochemical properties allowing the production of antibodies against antigens that normally can not be utilised as immunizing agents. The present invention furthermore relate to fields of use for harvested antigens in industry, agriculture and healthcare.

Priority: DK20060000054 Applic. Date: 2006-01-12; WO2007DK00018 Applic. Date: 2007-01-12

Inventor: LARSEN JANUS BEIERHOLM [DK]


Application No.: US20100143375A1  Published: 10/Jun/2010

Title: NEBULIZABLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARINIC RECEPTOR ANTAGONISTS

Applicant/Assignee: DEY, L.P

Application No.: 12/704767   Filing Date: 12/Feb/2010

Abstract:Compositions and methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders are provided. The compositions provided herein are nebulizable compositions comprising quaternary ammonium muscarinic receptor antagonists. The compositions are suitable for direct administration to a patient in need thereof via a nebulizer. Also provided are kits which comprise of the nebulizable composition of the invention in combination with a nebulizer. Also provided is a method of treating, preventing, or amelioration of one or more symptoms of bronchoconstrictive disorders by administering a therapeutically effective amount of the nebulizable composition of the invention via the use of a nebulizer to a patient in need thereof with minimal to no exposure of the nebulizable composition to the body surface of the patient.

Priority: US2007-753648 Applic. Date: 2007-05-25; US20060803309P Applic. Date: 2006-05-26

Inventor: CHAUDRY IMTIAZ A [US]


Application No.: US20100143423A1  Published: 10/Jun/2010

Title: ORAL CARE PRODUCT

Applicant/Assignee:

Application No.: 12/517365   Filing Date: 23/Nov/2007

Abstract:An oral care product comprising a first composition comprising an insoluble calcium salt that is not a calcium phosphate salt, a second independent composition comprising a source of phosphate ions, and a means for delivering each of the compositions to the surface of the teeth.

Priority: WO2006CN03278 Applic. Date: 2006-12-05; WO2007EP62744 Applic. Date: 2007-11-23

Inventor: BUTLER MICHAEL FRANCIS [GB]; DENG YAN [CN]; HEPPENSTALL-BUTLER MARY [GB]; JOINER ANDREW [GB]; LI HAIYAN [FR]; LI XIAOKE [CN]


Application No.: US20100143439A1  Published: 10/Jun/2010

Title: Hybrid Biomimetic Particles, Methods of Making Same and Uses Therefor

Applicant/Assignee: UNIVERSITY OF TOLEDO

Application No.: 12/596221   Filing Date: 14/Apr/2008

Abstract:Biomimetic microparticles for generation of tissue includes a biodegradable tissue replacement/repair matrix formed of a cross-linked scaffold material using a non-toxic multi-valent ionic cross-linking agent. One or more bioactive materials can be encapsulated and/or coated onto the biodegradable tissue replacement/repair matrix. The biomimetic microparticles are formed without exposure to high temperatures, high pressures, high voltages, and toxic chemicals.

Priority: US20070923715P Applic. Date: 2007-04-16; WO2008US04825 Applic. Date: 2008-04-14

Inventor: JAYASURIYA A CHAMPA [US]; EBRAHEIM NABIL A [US]


Application No.: US20100143474A1  Published: 10/Jun/2010

Title: B-CARBOLINE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Applicant/Assignee: ELLNEUROXX, LTD

Application No.: 12/528771   Filing Date: 26/Feb/2008

Abstract:The embodiments relate to derivatives of 9-alkyl-[beta]-carboline, their production and pharmaceutical compositions containing these 9-alkyl-[beta]-carboline derivatives. Further, the use of 9-alkyl-[beta]-carboline derivatives and pharmaceutical compositions for the treatment and prevention of movement disorders, neurodegenerative diseases, Alzheimer's disease and Parkinson's disease is described. Additionally, these effects can be utilized for the cultivation of cells such as dopaminergic cells or stem cells which shall be engrafted for the treatment of Parkinson's disease.

Priority: DE200710009264 Applic. Date: 2007-02-26; WO2008DE00332 Applic. Date: 2008-02-26

Inventor: ROMMELSPACHER HANS [DE]


Application No.: US20100143857A1  Published: 10/Jun/2010

Title: PHOTO-ACTIVATED DISINFECTION

Applicant/Assignee:

Application No.: 12/443905   Filing Date: 04/Oct/2007

Abstract:Photo-activated disinfection in the oral cavity is performed by a dental apparatus which includes a handpiece having proximal and distal portions, and a handpiece cover. The distal portion of the handpiece includes light emitting elements. The handpiece cover includes a sleeve adapted to provide a cover to the proximal portion of the handpiece and a sheath adapted to provide a cover to the distal portion of the handpiece. Suitably, the sleeve is a disposable component.

Priority: GB20060019588 Applic. Date: 2006-10-04; WO2007GB50612 Applic. Date: 2007-10-04

Inventor: COLLES MICHAEL JOHN [GB]


Application No.: US20100143863A1  Published: 10/Jun/2010

Title: Dental cleaning device

Applicant/Assignee:

Application No.: 12/316138   Filing Date: 10/Dec/2008

Abstract:A dental cleaning device includes a mouthpiece having an arcuately shaped casing pivotally coupled to a housing and having two opposed channels formed in the casing and arranged back-to-back, and sharing a common horizontal web for receiving teeth of a user and for receiving a water, and one or more vibrating devices, such as supersonic vibrating devices are engaged into the casing for vibrating the water to clean the teeth of the user without bristles or brushes, and for preventing the teeth of the user from being scraped or scrubbed by the bristles or brushes. A container is attached to the housing for receiving and supplying the water to the mouthpiece.

Priority:

Inventor: LIN SZU TENG [TW]


Application No.: US20100144598A1  Published: 10/Jun/2010

Title: Natural Polypeptides For Oral Health Care

Applicant/Assignee:

Application No.: 12/523502   Filing Date: 16/Jan/2008

Abstract:The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Statherin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.

Priority: US20070880753P Applic. Date: 2007-01-16; WO2008US51165 Applic. Date: 2008-01-16

Inventor: FINE DANIEL [US]; RAMASUBBU NARAYANAN [US]


Application No.: US20100144758A1  Published: 10/Jun/2010

Title: AZAINDOLE P2X3 AND P2X2/3 MODULATORS

Applicant/Assignee:

Application No.: 12/634031   Filing Date: 09/Dec/2009

Abstract:The application discloses compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein, X, R1, R2 R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Priority: US20080201422P Applic. Date: 2008-12-09

Inventor: DILLON MICHAEL PATRICK [US]; BOIS DAISY JOE DU [US]; LAI YINGJIE [US]; HAWLEY RONALD CHARLES [US]; WANG BEIHAN [CN]


Application No.: US20100144768A1  Published: 10/Jun/2010

Title: KINASE INHIBITOR COMPOUNDS

Applicant/Assignee:

Application No.: 12/451833   Filing Date: 05/Jun/2008

Abstract:Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer.

Priority: US20070933385P Applic. Date: 2007-06-06; WO2008US07123 Applic. Date: 2008-06-05

Inventor: LIANG CONGXIN [US]


Application No.: US20100145286A1  Published: 10/Jun/2010

Title: LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS

Applicant/Assignee: SEMPRUS BIOSCIENCES CORP

Application No.: 12/632669   Filing Date: 07/Dec/2009

Abstract:Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material

Priority: US20080120285P Applic. Date: 2008-12-05; US20080120292P Applic. Date: 2008-12-05; US20080120302P Applic. Date: 2008-12-05; US20090255264P Applic. Date: 2009-10-27

Inventor: ZHANG ZHENG [US]; HUVAL CHAD [US]; O'SHAUGHNESSEY WILLIAM SHANNAN [US]; HENCKE MICHAEL [US]; SQUIER TREVOR [US]; LI JUN [US]; BOUCHARD MICHAEL [US]; LOOSE CHRISTOPHER R [US]


Application No.: US20100145898A1  Published: 10/Jun/2010

Title: COMPUTER-ASSISTED CREATION OF A CUSTOM TOOTH SET-UP USING FACIAL ANALYSIS

Applicant/Assignee:

Application No.: 12/596231   Filing Date: 10/Apr/2008

Abstract:A method for automatic, or semi-automatic, planning of dental treatment for a patient comprises: (a) obtaining data about an area which is to be treated and data about a face of a patient

(b) performing a computer-assisted analysis of the data to determine properties of at least the face of the patient

(c) creating a modified tooth set-up using a set of stored rules which make use of the determined facial properties. A three-dimensional representation simulates the appearance of the modified tooth set-up and the patient's face surrounding the treatment area. The method also determines properties of existing teeth and creates a modified tooth set-up which is also based on the existing teeth of the patient. The method can be implemented as software running on a workstation.

Priority: GB20070007454 Applic. Date: 2007-04-18; WO2008EP03072 Applic. Date: 2008-04-10

Inventor: MALFLIET KATJA [BE]; PATTIJN VEERLE [BE]; VAN LIERDE CARL [BE]; VANCRAEN WILFRIED [BE]


Application No.: US20100146724A1  Published: 17/Jun/2010

Title: MOUTH CLEANING DEVICE

Applicant/Assignee:

Application No.: 12/531754   Filing Date: 18/Mar/2008

Abstract:Certain embodiments provide toothbrushes and/or other cleaning devices for contacting and cleaning teeth, gums, tongue, cheeks, and orthodontic appliance in an oral cavity. Certain embodiments provide a mouth cleaning device. The device includes a handle portion for holding and maneuvering the mouth cleaning device in an oral cavity. The device also includes a cleaning head portion including a core and a plurality of cleaning elements extending radially around the core, the core attached to the handle portion.

Priority: US20070895683P Applic. Date: 2007-03-19; US20070895669P Applic. Date: 2007-03-19; US20070911899P Applic. Date: 2007-04-15; US20070911901P Applic. Date: 2007-04-15; US20070979405P Applic. Date: 2007-10-12; US20070987409P Applic. Date: 2007-11-13; US20070987410P Applic. Date: 2007-11-13; WO2008US57363 Applic. Date: 2008-03-18

Inventor: JO HEEKYOUNG [US]


Application No.: US20100147252A1  Published: 17/Jun/2010

Title: Piston, Cylinder and Piston Assembly and Piston Ring for a Piston

Applicant/Assignee: MAHLE KONIG KOMMANDITGESELLSCHAFT GMBH & CO

Application No.: 12/652846   Filing Date: 06/Jan/2010

Abstract:A piston includes a piston head, two skirt walls disposed opposite one another and at least one pin bearing disposed between the skirt walls and supported on the piston head. Each skirt wall extends over a partial region of the periphery of the piston or piston head. The two skirt walls are connected by at least one self-supporting support wall disposed at a distance from the piston head. A cylinder and piston assembly and a piston ring for a cylinder, are also provided.

Priority: AT20070001049 Applic. Date: 2007-07-06; AT20070001639 Applic. Date: 2007-10-12; WO2008AT00112 Applic. Date: 2008-03-27

Inventor: LANGNER KARLHEINZ [AT]; ULRICH REINER [DE]


Application No.: US20100147298A1  Published: 17/Jun/2010

Title: INFANT PACIFIER FLUID DELIVERY DEVICE AND PACIFIER ASSEMBLY

Applicant/Assignee: A PLUS MEDICAL

Application No.: 12/636458   Filing Date: 11/Dec/2009

Abstract:A fluid delivery device for being secured on an infant pacifier comprises a fluid delivery nozzle configured to direct fluid toward an infant's nares and a nozzle support member secured to the fluid delivery nozzle and configured for being secured on the mouth shield of the pacifier.

Priority: US20080122234P Applic. Date: 2008-12-12

Inventor: LOESCHER THOMAS C [US]; FITZWATER DENNIS L [US]


Application No.: US20100147736A1  Published: 17/Jun/2010

Title: Container with Flattened Cap

Applicant/Assignee:

Application No.: 12/435918   Filing Date: 05/May/2009

Abstract:A biodegradable tube comprises a mom-rigid paper tubular body defining a lumen for containing a semi-solid composition

a paper tubular cap that slidably mates with the body

and wherein interior surfaces of the each of the body and the cap have a coating that is substantially impermeable to the semi-solid composition. In preferred embodiments the tube body and cap have tapered sealed ends, the coating comprises an adhesive, and the walls of the tube/cap comprise a rolled paper material upon which the coating has been applied. Contemplated semi-solid product materials include for example lip balm, facial cream, lotion, deodorant, sunscreen, caulk, grease sticks, mosquito repellant, and shoe polish.

Priority: US20080193689P Applic. Date: 2008-12-16

Inventor: WEST ELLERY [US]; WEST GAIL [US]


Application No.: US20100150656A1  Published: 17/Jun/2010

Title: Protective flood barrier system

Applicant/Assignee:

Application No.: 12/316249   Filing Date: 11/Dec/2008

Abstract:Protective flood barrier system on the base of mobile protective flood barriers is offered. Each of these barriers comprises two or more filled elongate sleeves, a web, connecting theirs web and forming means. Envelops of said sleeves and said web are made from flexible impermeable material. These barriers are convenient for protection of separate houses, the extensive areas, as walls of a water basin. They allow reducing wind-induced waves and can be used for repair of earthen dams. The high-efficiency means accelerating installation of barriers are provided.

Priority:

Inventor: FELDMAN BORIS [CA]; FELDMAN ALEXANDER [CA]; FELDMAN MICHAEL [CA]


Application No.: US20100150829A1  Published: 17/Jun/2010

Title: Antibodies to IL-6 and use thereof

Applicant/Assignee:

Application No.: 12/624778   Filing Date: 24/Nov/2009

Abstract:The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

Priority: US2009-502581 Applic. Date: 2009-07-14; US2009-399156 Applic. Date: 2009-03-06; US2009-391717 Applic. Date: 2009-02-24; US2009-366567 Applic. Date: 2009-02-05; US20080117839P Applic. Date: 2008-11-25; US20080117861P Applic. Date: 2008-11-25; US20080117811P Applic. Date: 2008-11-25

Inventor: GARCIA-MARTINEZ LEON [US]; JENSEN ANNE ELISABETH CARVALHO [US]; OLSON KATIE [US]; DUTZAR BEN [US]; LATHAM JOHN [US]; KOVACEVICH BRIAN [US]; SMITH JEFFREY T L [US]; LITTON MARK [US]; SCHATZMAN RANDALL [US]


Application No.: US20100150847A1  Published: 17/Jun/2010

Title: THERAPEUTIC DENTAL COMPOSITION AND RELATED METHODS

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/594994   Filing Date: 10/Jul/2008

Abstract:Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.

Priority: US20070951761P Applic. Date: 2007-07-25; WO2008US69651 Applic. Date: 2008-07-10

Inventor: YANG JIE [US]; VELAMAKANNI BHASKAR V [US]; MITRA SUMITA B [US]; POCIUS ALPHONSUS V [US]; STOFKO JR JOHN J [US]; YARWOOD JEREMY M [US]


Application No.: US20100150891A1  Published: 17/Jun/2010

Title: MEDICINAL COMPOSITION, FOOD OR DRINK HAVING EFFECT OF ENHANCING PARASYMPATHETIC NERVOUS ACTIVITY

Applicant/Assignee: SUNTORY HOLDINGS LIMITED

Application No.: 12/593468   Filing Date: 28/Mar/2008

Abstract:It is intended to provide a safe composition for treating a disease or condition relating to autonomic nervous activity which has an autonomic nervous control effect

in particular, an effect of enhancing parasympathetic nervous activity. Thus, a medicinal composition, a food or a drink containing L-phenyl lactic acid and/or D-phenyl lactic acid and having an autonomic nervous control effect is provided.

Priority: JP20070092528 Applic. Date: 2007-03-30; WO2008JP56076 Applic. Date: 2008-03-28

Inventor: BEPPU YOSHINORI [JP]; TSURUOKA NOBUO [JP]; KOMURA HAJIME [JP]; NAGAI KATSUYA [JP]


Application No.: US20100150972A1  Published: 17/Jun/2010

Title: Paper Tube Packaging with Open End And Coated Cap

Applicant/Assignee:

Application No.: 12/435852   Filing Date: 05/May/2009

Abstract:A biodegradable tube comprises a mom-rigid paper tubular body defining a lumen for containing a semi-solid composition

a paper tubular cap that slidably mates with the body

and wherein interior surfaces of the each of the body and the cap have a coating that is substantially impermeable to the semi-solid composition. In preferred embodiments the tube body and cap have tapered sealed ends, the coating comprises an adhesive, and the walls of the tube/cap comprise a rolled paper material upon which the coating has been applied. Contemplated semi-solid product materials include for example lip balm, facial cream, lotion, deodorant, sunscreen, caulk, grease sticks, mosquito repellant, and shoe polish.

Priority: US20080193689P Applic. Date: 2008-12-16

Inventor: WEST ELLERY [US]; WEST GAIL [US]


Application No.: US20100151029A1  Published: 17/Jun/2010

Title: Anti-infectious hydrogel compositions

Applicant/Assignee: HYDROMER, INC

Application No.: 12/658937   Filing Date: 16/Feb/2010

Abstract:The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a polysaccharide and water.

Priority: US2004-788663 Applic. Date: 2004-02-27

Inventor: GRUENING RAINER [US]; PERSCHBACHER DOUG J [US]; QU XIN [US]; BUONGIOVANNI DAVID [US]


Application No.: US20100151032A1  Published: 17/Jun/2010

Title: Silver and Zinc Containing Body Care Agent

Applicant/Assignee: BIO-GATE AG

Application No.: 12/714251   Filing Date: 26/Feb/2010

Abstract:The invention relates to a body care agent containing metal particles which release zinc and silver ions in said body care agent by contacting body liquid or body humidity and whose metallic silver content at least equal or greater than 99 % (m/m).

Priority: DE20031040276 Applic. Date: 2003-08-29; US2006-569709 Applic. Date: 2006-10-02; WO2004EP09534 Applic. Date: 2004-08-26

Inventor: BECHERT THORSTEN [DE]; WAGENER MICHAEL [DE]; STEINRUECKE PETER [DE]


Application No.: US20100151407A1  Published: 17/Jun/2010

Title: DEVICE HAVING ACTIVATED TEXTURED SURFACES FOR TREATING ORAL TISSUE

Applicant/Assignee:

Application No.: 12/711797   Filing Date: 24/Feb/2010

Abstract:Mouthpieces having activated textured surfaces that can be implemented using repetitive movement mechanisms and energy (e.g., electromagnetic radiation) emitting sources are disclosed. The mouthpieces may be used to provide detection, treatment and management of conditions including tooth discoloration and periodontal disease. Implementations can include a low-profile mouthpiece or a mouthpiece covering only front sides of the upper and lower teeth. Other combinations may include full-mouth implementations suitable for simultaneously covering part or all of a patient's upper and lower rows of teeth. The activated textured surfaces may include a surface topography consisting of bristles.

Priority: US2006-441788 Applic. Date: 2006-05-25; US2006-590603 Applic. Date: 2006-10-30; US2003-624847 Applic. Date: 2003-07-22; US2001-991533 Applic. Date: 2001-11-15; US20050684418P Applic. Date: 2005-05-25; US20050703962P Applic. Date: 2005-07-29; US20050739273P Applic. Date: 2005-11-23; US20000249015P Applic. Date: 2000-11-15

Inventor: RIZOIU IOANA M [US]; BOUTOUSSOV DMITRI [US]; JONES JEFFREY W [US]; KIMMEL ANDREW I [US]


Application No.: US20100151425A1  Published: 17/Jun/2010

Title: Reinforcing preform in the form of a meshed grid and composite material with preimpregnated fibers for a dental prosthesis, and method for producing the grid

Applicant/Assignee:

Application No.: 12/654201   Filing Date: 14/Dec/2009

Abstract:A preform made of composite material designed to be formed on a laboratory model and to be integrated in a base plate of a dental prosthesis. The preform comprises a grid formed by a meshing of weft threads and warp threads coated in an impregnating resin, the space between the meshes being exempt of fibers and resin, and determining a surface of free spaces of more than 25% of the total surface of the grid. The weft threads are fixed onto the warp threads at the nodes of the meshing to enable the preform to be handled and to be formed on a laboratory model, without the impregnating resin creeping into the spaces of the meshes.

Priority: FR20080007056 Applic. Date: 2008-12-16

Inventor: CLUNET-COSTE BRUNO [FR]; MANEUF BERNARD [FR]; COLLOMBIN ANDRE [FR]; LE GUAY YANNICK [FR]


Application No.: US20100152176A1  Published: 17/Jun/2010

Title: Modulators of Muscarinic Receptors

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/710027   Filing Date: 22/Feb/2010

Abstract:The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Priority: US2007-893245 Applic. Date: 2007-08-15; US20060837786P Applic. Date: 2006-08-15

Inventor: MAKINGS LEWIS R [US]; HURLEY DENNIS J [US]; RAFFAI GABRIEL [US]


Application No.: US20100152184A1  Published: 17/Jun/2010

Title: PHARMACEUTICAL COMPOUNDS

Applicant/Assignee: ASTEX THERAPEUTICS LIMITED

Application No.: 12/445154   Filing Date: 12/Oct/2007

Abstract:The invention provides a compound for use in medicine, the compound being a compound of the formula (VI0) or a salt, solvate, tautomer or N-oxide thereof: wherein the bicyclic group: is selected from the structures C1, C5 and C6: wherein n is 0, 1, 2 or 3

R1 is hydrogen, hydroxy, or O-Rz

R2a is hydroxy, methoxy or O-Rz

provided that at least one of R1 and R2a is O-Rz

Rz is Lp-Rp1

SO3H

a glucuronide residue

a mono-, di- or tripeptide residue

or Lp is a bond, C-O, (C-O)O, (C-O)NRp1 or S(O)xNRp1

x is 1 or 2

Rp1 is hydrogen or a an optionally substituted C1-25 hydrocarbyl group containing 0, 1 or 2 carbocyclic rings and 0, 1, 2, 3, 4, 5 or 6 carbon-carbon multiple bonds, provided that Rp1 is not hydrogen when Lp is a bond, C-O or (C-O)O

and provided also that O-Rz does not contain an O-O moiety

and excluding compounds wherein R1 is hydroxy and R2a is methoxy

Rp2 and Rp3 are the same or different and each is a group Rp1

and R3, R4a, R8 and R10 are defined in the claims. The compounds of formula (VI0) are pro-drugs of parent compounds wherein R1 and/or R2a are hydroxy, wherein the parent compounds have Hsp90 inhibiting activity.

Priority: US20060859246P Applic. Date: 2006-11-16; WO2007GB03860 Applic. Date: 2007-10-12

Inventor: CONGREVE MILES STUART [GB]; FAZAL LYNSEY HELEN [GB]; FREDERICKSON MARTYN [GB]; MURRAY CHRISTOPHER WILLIAM [GB]; O'BRIEN MICHAEL ALISTAIR [GB]; WOODHEAD ANDREW JAMES [GB]; LYONS JOHN FRANCIS [GB]; THOMPSON NEIL THOMAS [GB]


Application No.: US20100152203A1  Published: 17/Jun/2010

Title: THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Applicant/Assignee:

Application No.: 12/636723   Filing Date: 12/Dec/2009

Abstract:Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Priority: US20080122889P Applic. Date: 2008-12-16

Inventor: CHEN LI [CN]; FENG LICHUN [CN]; YANG MINMIN [CN]; DILLON MICHAEL PATRICK [US]; LAI YINGJIE [US]


Application No.: US20100152318A1  Published: 17/Jun/2010

Title: DENTAL GLASS COMPOSITION

Applicant/Assignee:

Application No.: 11/719150   Filing Date: 28/Oct/2005

Abstract:An aluminosilicate glass composition comprising: (a) 10-35% by weight of silica

(b) 10-35% by weight of alumina

(c) 3-30% by weight of zinc oxide

(d) 4-30% by weight P205

and (e) 3-25% by weight of fluoride which contains at most 3% by weight of alkaline metals calculated as M20, wherein M is Li, Na, and/or K, and wherein the weight ratio of the sum of zinc oxide and fluoride to P205 of from 0.8 to 3.0.

Priority: EP20040027012 Applic. Date: 2004-11-12; WO2005EP11584 Applic. Date: 2005-10-28

Inventor: BLACKWELL GORDON [DE]


Application No.: US20100152634A1  Published: 17/Jun/2010

Title: Rotating Stream Oral Hygiene System

Applicant/Assignee:

Application No.: 12/639842   Filing Date: 16/Dec/2009

Abstract:An oral hygiene system for cleaning teeth and gums with a fluid, the system comprising a reservoir for storing the fluid

a body portion connected to the reservoir, having pumping means a motor, for controllably drawing fluid from the reservoir

and a nozzle extending from the body portion for receiving the fluid from the reservoir and having a distal tip for discharging the fluid to a user's teeth and gums

wherein the fluid is discharged as a single rotating stream from the distal tip of the nozzle. There may be a valve for controlling the flow of fluid, which may be water, a dental rinse, or other desired fluid.

Priority: US20080138432P Applic. Date: 2008-12-17

Inventor: DOVE NORMAN [CA]


Application No.: US20100152645A1  Published: 17/Jun/2010

Title: Facial Hair-Growth Device and Facial Hair-Growth System

Applicant/Assignee:

Application No.: 12/522531   Filing Date: 04/Jan/2008

Abstract:Compared to a conventional halogen lamp and optical filter, wavelength range of a light is narrowed, throughput of a desired wavelength range is increased, and irradiation of a light of a different wavelength range is enabled. The present apparatus for facial treatment and hair restoration is a combination of a light source means, which is a light source of a monochromatic light of an ultra narrow bandwidth having a half bandwidth of 10 nm or less emitted from a monochromatic LED light source, a monochromatic laser diode light source, or a laser light source, and a diffusion means. Specifically, in a case where the LED light source is used, the apparatus includes a bandpass filter for focusing the wavelength range of each light emitted from the light source and a diffusion lens for diffusing a light which passed through the filter and has an ultra narrow bandwidth with a half bandwidth of 10 nm or less.

Priority: JP20070001538 Applic. Date: 2007-01-09; JP20070001539 Applic. Date: 2007-01-09; WO2008JP50002 Applic. Date: 2008-01-04

Inventor: OGASAWARA MASAHIRO [JP]


Application No.: US20100152708A1  Published: 17/Jun/2010

Title: NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS

Applicant/Assignee: SEMPRUS BIOSCIENCES CORP

Application No.: 12/632686   Filing Date: 07/Dec/2009

Abstract:Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

Priority: US20080120285P Applic. Date: 2008-12-05; US20080120292P Applic. Date: 2008-12-05; US20090231346P Applic. Date: 2009-08-05

Inventor: LI JUN [US]; SQUIER TREVOR [US]; ZHANG ZHENG [US]; HUVAL CHAD [US]; O'SHAUGHNESSY WILLIAM SHANNAN [US]; HENCKE MICHAEL [US]; BOUCHARD MICHAEL [US]; LOOSE CHRISTOPHER R [US]


Application No.: US20100154364A1  Published: 24/Jun/2010

Title: Rotatable bottle or container capping machine for screwing threaded screw caps onto a threaded mouth portion of filled bottles or containers to close filled bottles or containers, and a method of operation thereof

Applicant/Assignee:

Application No.: 12/492266   Filing Date: 26/Jun/2009

Abstract:Rotatable bottle or container capping machine for screwing threaded screw caps onto a threaded mouth portion of filled bottles or containers to close filled bottles or containers, and a method of operation thereof. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. PRG 1.72(b). As stated in 37 C.F.R. PRG 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading "Abstract of the Disclosure." The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Priority: DE20031052016 Applic. Date: 2003-11-07; US2004-982694 Applic. Date: 2004-11-05

Inventor: BERNHARD HERBERT [DE]


Application No.: US20100154809A1  Published: 24/Jun/2010

Title: MULTI-COMPONENT FILTER PROVIDING MULTIPLE FLAVOUR ENHANCEMENT

Applicant/Assignee: PHILIP MORRIS USA INC

Application No.: 12/716752   Filing Date: 03/Mar/2010

Abstract:A multi-component filter for a smoking article comprises: a mouth end segment

a first flavour release segment comprising plant leaf upstream of the mouth end segment

and a second flavour release segment comprising filtration material and a flavourant upstream of the first flavour release segment. The resistance to draw of the second flavour release segment is greater than the resistance to draw of the first flavour release segment and the resistance to draw of the second flavour release segment is greater than the resistance to draw of the mouth end segment. The multi-component filter preferably further comprises a rod end segment comprising filtration material upstream of the second flavour release segment, which has a lower resistance to draw than the second flavour release segment.

Priority: EP20060254102 Applic. Date: 2006-08-04; US2007-882115 Applic. Date: 2007-07-30

Inventor: SEITERT HUGUES [CH]; GAWAD AHMED [CH]; LEKILI LEVENT [CH]; KUERSTEINER CHARLES [CH]


Application No.: US20100155652A1  Published: 24/Jun/2010

Title: METHOD FOR GENERATING POLLUTION CREDITS

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 12/716092   Filing Date: 02/Mar/2010

Abstract:A method for the development or generation of pollution credits by the substitution of lower global warming potential (GWP) mixtures of halogenated hydrocarbons or mixtures of halogenated hydrocarbons with CO2 for fluorocarbons or fluorocarbon-containing compositions of higher GWP, such as for perfluorocarbon compounds (PFC's), hydrofluorocarbon compounds (HFC's), chlorofluorocarbons (CFC's), hydrochlorofluorocarbon compounds (HCFC's), and compositions thereof, in compositions and processes employing the higher GWP compounds, and receive allocation of pollution credits for such substitution.

Priority: US2006-373426 Applic. Date: 2006-03-10

Inventor: LULY MATTHEW H [US]; SINGH RAJIV R [US]


Application No.: US20100158818A1  Published: 24/Jun/2010

Title: ANTIMICROBIAL N-CHLORINATED COMPOSITIONS

Applicant/Assignee: NOVABAY PHARMACEUTICALS, INC

Application No.: 12/614347   Filing Date: 06/Nov/2009

Abstract:The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.

Priority: US20080112674P Applic. Date: 2008-11-07

Inventor: JAIN RAKESH K [US]; LOW EDDY [US]; FRANCAVILLA CHARLES [US]; SHIAU TIMOTHY P [US]; NAIR SATHEESH K [US]


Application No.: US20100158820A1  Published: 24/Jun/2010

Title: XYLITOL DENTAL MAINTENANCE SYSTEM

Applicant/Assignee:

Application No.: 12/648188   Filing Date: 28/Dec/2009

Abstract:A system, kit and method for promoting oral hygiene are disclosed. The kit may comprise several compositions or a single composition, each of which comprises an effective amount of xylitol. For example, the system and kit may comprise a chewing gum composition, a morsel composition, a paste-like composition, and an oral rinse composition

or any one of the above compositions

or any combination of the above compositions. It will be appreciated that a novel method for using such a system and kit for promoting oral hygiene may include: administering about 0.5 grams to about 2.0 grams of xylitol through the paste-like composition in the morning and in the evening, administering about 0.5 grams to about 2.0 grams of xylitol after consumption of nutrition through chewing the gum composition or through the morsel composition, and administering about 0.5 grams to about 1.5 grams of xylitol per application through the oral rinse composition.

Priority: US2004-873766 Applic. Date: 2004-06-21; US20030480516P Applic. Date: 2003-06-20

Inventor: BAILEY DONALD W [US]


Application No.: US20100158821A1  Published: 24/Jun/2010

Title: ANTIMICROBIAL AGENTS, COMPOSITIONS AND PRODUCTS CONTAINING THE SAME, AND METHODS OF USING THE COMPOSITIONS AND PRODUCTS

Applicant/Assignee: EASTMAN CHEMICAL COMPANY

Application No.: 12/341462   Filing Date: 22/Dec/2008

Abstract:Antimicrobial agents, products and compositions incorporating the agents, and methods of using the compositions and products are provided. The antimicrobial agents comprise 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, or mixtures thereof. These agents have surprisingly been found to inhibit microbial growth at a much lower concentration than other glycols with known antimicrobial activity.

Priority:

Inventor: MCCAULLEY JAMES ALLEN [US]; OLDFIELD TERRY ANN [US]; MATOSKY ANDREW JOSEPH [US]; DOBBS SUZANNE WINEGAR [US]; CHRISTIAN VICKY LYNN [US]; WATTERSON THELMA LEE [US]; SEO KAB SIK [US]; KINKADE NANCY [US]; POSEY-DOWTY JESSICA [US]


Application No.: US20100158822A1  Published: 24/Jun/2010

Title: PEPTIDES THAT BIND TO SILICA-COATED PARTICLES

Applicant/Assignee: E .I. DU PONT DE NEMOURS AND COMPANY

Application No.: 12/632829   Filing Date: 08/Dec/2009

Abstract:Peptides having strong affinity for silica as well as surfaces comprising silica are described. The silica-binding peptides may be used to construct peptide based-reagents suitable for delivery of a silica-coated particulate benefit agent to a surface, such as body surface, for personal care and cosmetic applications. Peptide-based reagents formed by coupling at least one of the silica-binding peptides to at least one body surface-binding peptide, either directly or through a spacer, are described. The peptide-based reagents may be used in conjunction with at least one silica-coated colorant to color body surfaces.

Priority: US20080138631P Applic. Date: 2008-12-18

Inventor: FAHNESTOCK STEPHEN R [US]; FOSSER KARI A [US]; PARTHASARATHY ANJU [US]; WANG HONG [US]


Application No.: US20100158823A1  Published: 24/Jun/2010

Title: PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 12/632831   Filing Date: 08/Dec/2009

Abstract:Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.

Priority: US20080138633P Applic. Date: 2008-12-18

Inventor: CHENG QIONG [US]; FAHNESTOCK STEPHEN R [US]; HE HONGXIAN [US]; KOSTICHKA KRISTY N [US]; WANG HONG [US]


Application No.: US20100158854A1  Published: 24/Jun/2010

Title: METHOD FOR TREATMENT OF AIRWAY AND APPARATUS AND KIT FOR USE THEREWITH

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 12/553905   Filing Date: 03/Sep/2009

Abstract:A method of treating an airway in a mammalian body having a mouth, soft palate, uvula, throat and tongue. An implant-forming material is introduced into at least one of the soft palate and uvula for treating at least one of snoring and sleep apnea. An apparatus and kit are provided.

Priority: US20080139247P Applic. Date: 2008-12-19

Inventor: PUISAIS NATHALIE [FR]


Application No.: US20100158960A1  Published: 24/Jun/2010

Title: POROUS POLYMER COATING FOR TOOTH WHITENING

Applicant/Assignee:

Application No.: 12/338357   Filing Date: 18/Dec/2008

Abstract:The present invention relates to a tooth-whitening composition comprising (i) a substantially water-insoluble and substantially non-degradable polymer matrix component capable of adhering to the surface of a tooth, provided that if the polymer matrix component is in non-solid form, it is solidifable by chemical alteration

and (ii) gas- or liquid-filled pores embedded in said polymer matrix component, wherein at least a portion of said gas- or liquid-filled pores have at least one size dimension in the range of about 70 nm to about 5 microns, and wherein the gas- or liquid-filled pores and polymer matrix component possess a difference in refractive index of at least 0.1. The invention is also directed to a tooth-whitening system containing the above composition in combination with an applicator device. The invention is also directed to methods for applying the tooth-whitening composition onto teeth.

Priority:

Inventor: CHANDRA DINESH [US]; SOSHINSKY ANDRE A [US]; GAMBOGI ROBERT J [US]; YANG SHU [US]


Application No.: US20100158988A1  Published: 24/Jun/2010

Title: CEREAL BETA GLUCAN COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF

Applicant/Assignee: CEAPRO, INC

Application No.: 12/716588   Filing Date: 03/Mar/2010

Abstract:Cereal [beta](1-3) [beta](1-4) glucan is used as a film or coating agent to produce clear, edible, biodegradable, delivery, lubricating, and protecting agents. Cereal [beta](1-3) [beta](1-4) glucans are distinctive polymers of glucose differentiated from other polymers by not only their source but also their physicochemical properties. The [beta](1-3) [beta](1-4) forms a matrix to sequester other materials, such as pharmaceutical, medical and therapeutic agents, flavours, fragrances. The technology has applications to essential oils and non-aqueous materials that are rendered deliverable by the [beta](1-3) [beta](1-4) glucan. The [beta](1-3) [beta](1-4) glucan films described may be consumed whereby they dissolve in the mouth in a controlled manner and may be used for the delivery of pharmaceutical, medical or confectionery products.

Priority: US2004-498568 Applic. Date: 2004-07-21; WO2002CA01896 Applic. Date: 2002-12-11; US20010338649P Applic. Date: 2001-12-11

Inventor: REDMOND MARK J [CA]; FIELDER DAVID A [CA]


Application No.: US20100158997A1  Published: 24/Jun/2010

Title: BLOW-MOLDED THIN-WALLED DRUG DELIVERY CAPSULES

Applicant/Assignee:

Application No.: 12/639873   Filing Date: 16/Dec/2009

Abstract:A thin-walled capsule of defined permeability is produced by blow-molding an aqueous-based polymer composition.

Priority: US20080138844P Applic. Date: 2008-12-18

Inventor: DONG LIANG CHANG [US]


Application No.: US20100159416A1  Published: 24/Jun/2010

Title: DISPOSABLE DENTAL PROPHYLAXIS INSTRUMENT CAPABLE OF DISCHARGING DENTIFRICE MATERIAL

Applicant/Assignee:

Application No.: 12/342081   Filing Date: 23/Dec/2008

Abstract:The present invention relates to a disposable dental instrument used by dental professionals to polish a patient's teeth. The dental instrument can be connected to a hand motor used to rotate a prophy cup with a plurality of grinding wings that rub against the patient's teeth as a predetermined amount of tooth cleaning fluid is discharged directly on the patient's teeth through a drain hole within the prophy cup. The tooth cleaning fluid is discharged from a tube that is assembled in a tube room of the dental instrument. The tube is a flexible bladder similar in function and form to a tube of toothpaste. The tube is made of a flexible polymer material that allows it to be squeezed when pressure is applied to it. A roller is assembled within the tube room and on top of the tube.

As the roller is pushed forward with a finger, the tube is squeezed to discharge the tooth cleaning fluid directly on the patient's teeth.

Priority:

Inventor: LEE KWANG S [US]; GHIM DUKE K [US]


Application No.: US20100160289A1  Published: 24/Jun/2010

Title: SULFONAMIDES AS TRPM8 MODULATORS

Applicant/Assignee:

Application No.: 12/638550   Filing Date: 15/Dec/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.

Priority: US20080138613P Applic. Date: 2008-12-18

Inventor: MACIELAG MARK J [US]; MCNALLY JAMES J [US]


Application No.: US20100160291A1  Published: 24/Jun/2010

Title: TRICYCLIC SPIRO-OXINDOLE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/445271   Filing Date: 12/Oct/2007

Abstract:This invention is directed to tricyclic spiro-oxindole derivatives of formula (I), wherein j, k, m, n, w, q, Y, Q, X, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Priority: US20060851190P Applic. Date: 2006-10-12; WO2007US81240 Applic. Date: 2007-10-12

Inventor: CHAFEEV MIKHAIL [CA]; CHOWDHURY SULTAN [CA]; FU JIANMIN [CA]; KAMBOJ RANJENDER [CA]


Application No.: US20100160316A1  Published: 24/Jun/2010

Title: QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/714871   Filing Date: 01/Mar/2010

Abstract:The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Priority: US2004-935008 Applic. Date: 2004-09-02; US2004-792688 Applic. Date: 2004-03-03; US20030451458P Applic. Date: 2003-03-03; US20030463797P Applic. Date: 2003-04-18

Inventor: GONZALEZ III JESUS E [US]; WILSON DEAN M [US]; TERMIN ANDREAS P [US]; GROOTENHUIS PETER D J [US]; ZHANG YULIAN [US]; PETZOLDT BENJAMIN J [US]; FANNING LEV TYLER DEWEY [US]; NEUBERT TIMOTHY D [US]; TUNG ROGER D [US]; MARTINBOROUGH ESTHER [US]; ZIMMERMAN NICOLE [US]


Application No.: US20100160333A1  Published: 24/Jun/2010

Title: NOVEL 3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee:

Application No.: 12/716111   Filing Date: 02/Mar/2010

Abstract:3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.

Priority: DK20060000189 Applic. Date: 2006-02-10; DK20060000192 Applic. Date: 2006-02-10; US2008-161905 Applic. Date: 2008-07-23; WO2007EP51270 Applic. Date: 2007-02-09

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100160337A1  Published: 24/Jun/2010

Title: SULFAMIDES AS TRPM8 MODULATORS

Applicant/Assignee:

Application No.: 12/638506   Filing Date: 15/Dec/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.

Priority: US20080138598P Applic. Date: 2008-12-18

Inventor: MATTHEWS JAY M [US]


Application No.: US20100160485A1  Published: 24/Jun/2010

Title: Hydrolysis stable self-etching, self-priming adhesive

Applicant/Assignee:

Application No.: 12/583860   Filing Date: 27/Aug/2009

Abstract:An aqueous one-pack self-etching and self-priming dental adhesive composition having a pH of at most 2, which comprises: (i) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer which optionally contains an inorganic acidic moiety selected from a phosphonic acid moiety or a sulfonic acid moiety, and (ii) a curing system.

Priority: US2008-077644 Applic. Date: 2008-03-20; US2004-493721 Applic. Date: 2004-04-26; WO2002EP11940 Applic. Date: 2002-10-25; US20010345994P Applic. Date: 2001-10-26

Inventor: KLEE JOACHIM [DE]; WALZ UWE [DE]; LEHMAN UWE [DE]


Application No.: US20100163072A1  Published: 01/Jul/2010

Title: Dental Floss Holder

Applicant/Assignee:

Application No.: 12/160600   Filing Date: 04/Jan/2007

Abstract:The utility model of a dental floss holder concerns a device to handle dental floss to clean the spaces between the teeth consisting of two interconnected but easily separable holder portions: Portion 1-U shape supporter is provided with a U supporter (1) with two folding legs, connecting part (2) with longitudinal groove (6) and external thread (7), a hole (3) in the rear leg, a groove (4) that goes externally from the end of the front leg to the fixed end of U supporter (1) to hold the dental floss in position during cleaning operation. Portion 2-Hollow grip provided with a fixed side with a longitudinal inner blade (8) and the rotating side with a rotary end (9) and an internal thread (10). These two portions constitute a mechanism that limits the maximum floss tension adjusted by the rotary end (9). The device can operate with a piece of floss or from a floss supplier (12) connected to the rotary end (9).

Priority: BR2006MU8600037U Applic. Date: 2006-01-12; WO2007BR00005 Applic. Date: 2007-01-04

Inventor: SHINZATO NELSON [BR]


Application No.: US20100163073A1  Published: 01/Jul/2010

Title: MEDICAL CLEANING TOOL

Applicant/Assignee: NUMAT AS

Application No.: 12/599741   Filing Date: 15/Sep/2008

Abstract:A medical cleaning tool (1) having an elongated base member (2) formed of at least two wires (3) being twisted with each other. In addition, the medical cleaning tool has a plurality of bristles (4) fixed between the twisted wires and extending away from the twisted wires, whereby the bristles are positioned in a cleaning section (5) at a first end (6) of the base member (2). The bristles are titanium or a titanium alloy.

Priority: SE20070002890 Applic. Date: 2007-12-27; US20070009195P Applic. Date: 2007-12-27; US20080129275P Applic. Date: 2008-06-16; WO2008EP62237 Applic. Date: 2008-09-15

Inventor: LYNGSTADAAS STAALE PETTER [NO]; ELLINGSEN JAN EIRIK [NO]; WOHLFAHRT JOHAN CASPAR [NO]


Application No.: US20100166679A1  Published: 01/Jul/2010

Title: SWEETNER AND USE

Applicant/Assignee: PURECIRCLE SDN BHD

Application No.: 12/684130   Filing Date: 08/Jan/2010

Abstract:Sweeteners on the basis of a simultaneously transglucosylated sweet glycoside mixture of Stevia rebaudiana Bertoni are prepared. The transglucosylation was developed in the presence of starch under the action of cyclodextrin glucanotransferase. The remaining maltodextrins are transformed to the fructose-terminated oligosaccharides by the addition of sucrose. The sweeteners are purified to not less than 98% content of sweet glycosides and derivatives. The preparations are almost non-caloric, non-cariogenic, non-bitter, non-lingering sweeteners, which may be advantageously applied in foods, beverages, cosmetics and milk products.

Priority: US2005-246066 Applic. Date: 2005-10-11

Inventor: ABELYAN VARUZHAN [MY]; MARKOSYAN AVETIK [MY]; ABELYAN LIDIA [MY]


Application No.: US20100166680A1  Published: 01/Jul/2010

Title: METHOD FOR PRODUCTION OF BIOCOMPATIBLE NANOPARTICLES CONTAINING DENTAL ADHESIVE

Applicant/Assignee: IRAN POLYMER AND PETROCHEMICAL INSTITUTE

Application No.: 12/723649   Filing Date: 14/Mar/2010

Abstract:A method of synthesizing hydroxyapatite nanorods, having high purity, high crystallinity and high aspect ratio is disclosed here. In one embodiment, high crystalline hydroxyapatite nanorods with relatively stoichiometric structure are prepared via hydrothermal method at 200 DEG C. and under moderate acidic conditions. The synthesized hydroxyapatite nanorods have a diameter of 30-95 nm, a length of 850-1400 nm with an average aspect ratio of 24, degree of crystallinity of 73% and stoichiometry ratio of 1.69. Further it discloses the use of HAp in dental adhesive. The dental adhesive comprising synthesized HAp shows improved diametral tensile strength and high microshear bond strength. Energy dispersive X-ray mapping confirmed the uniform distribution of nanorods in the adhesive matrix. The synthesized hydroxyapatite nanorods have high colloidal stability in the dental adhesive solution. The nanorods are well dispersed and protected from aggregation by their high surface charges confirmed by zeta potential measurement.

Priority: US20090261158P Applic. Date: 2009-11-13

Inventor: SADAT-SHOJAI MEHDI [IR]; ATAI MOHAMMAD [IR]; NODEHI AZIZOLLAH [IR]


Application No.: US20100166799A1  Published: 01/Jul/2010

Title: ADENOVIRAL VECTORS AND METHODS AND USES RELATED THERETO

Applicant/Assignee: ONCOS THERAPEUTICS

Application No.: 12/643140   Filing Date: 21/Dec/2009

Abstract:The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to a use of said vectors in the manufacture of a medicament for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing GM-CSF in a cell and increasing tumor specific immune response in a subject, as well as uses of the oncolytic adenoviral vector of the invention for producing GM-CSF in a cell and increasing tumor specific immune response in a subject.

Priority: FI20080000671 Applic. Date: 2008-12-22; FI20090005466 Applic. Date: 2009-04-27; US2009-585971 Applic. Date: 2009-09-29

Inventor: HEMMINKI AKSELI [FI]; KANERVA ANNA [FI]; CERULLO VINCENZO [FI]; PESONEN SARI [FI]


Application No.: US20100166809A1  Published: 01/Jul/2010

Title: METHODS OF TREATING OR PREVENTING BIOFILM ASSOCIATED INFECTIONS WITH FREE AVAILABLE CHLORINE FREE AVAILABLE CHLORINE WATER

Applicant/Assignee: OCULUS INNOVATIVE SCIENCES

Application No.: 12/645419   Filing Date: 22/Dec/2009

Abstract:The invention provides methods of treating or reducing the incidence of an infection in a mammal due to a biofilm associated infectious microorganism comprising administering a therapeutically effective amount of free available chlorine (FAC) water to a site populated with biofilm associated infectious microorganism.

Priority: US20080139972P Applic. Date: 2008-12-22

Inventor: NORTHEY ROBERT [US]; THATCHER EILEEN [US]; GUTIERREZ ANDRES [US]


Application No.: US20100166810A1  Published: 01/Jul/2010

Title: COMBINATION TABLET WITH CHEWABLE OUTER LAYER

Applicant/Assignee:

Application No.: 12/646395   Filing Date: 23/Dec/2009

Abstract:A pharmaceutical composition in the form of a combination tablet is described. The tablet has a rapidly absorbed component that enters the circulation by traversing the buccal mucosa, oral mucosa and combinations thereof, and a more slowly absorbed component that is swallowed. The therapeutic agent in the swallowed portion is absorbed across the gastric mucosa. The combination tablet may be modified, by varying the specific combinations of excipients, fillers, and the like to effect distinct release rates. In addition, the rapid and slow components may have identical or different therapeutic agents depending on the application to a specific medical condition. One embodiment of the combination tablet includes a prostaglandin inhibitor in the rapidly absorbed component in order to mitigate the side effects of immediate release niacin that is in the slow absorbing component. Such combination compositions will increase patient compliance with various dosing regimens due to the resultant decrease in the number of tablets that a patient would need to take on a daily basis.

Priority: WO2008US08191 Applic. Date: 2008-07-01; US20070947440P Applic. Date: 2007-07-01

Inventor: HABBOUSHE JOSEPH PETER [US]


Application No.: US20100166812A1  Published: 01/Jul/2010

Title: TOOTHPOWDER COMPOSITION CONTAINING WHEAT FLOUR AND BAMBOO SALT

Applicant/Assignee:

Application No.: 12/571285   Filing Date: 30/Sep/2009

Abstract:Disclosed are a toothpowder composition and a method for manufacturing the same. The disclosed toothpowder composition contains wheat flour and bamboo salt. The method includes addition of wheat flour and bamboo salt to prepare a powder mixture. Further disclosed is a method of manufacturing a tooth-washing tablet using the toothpowder composition.

Priority: KR20080137229 Applic. Date: 2008-12-30; KR20090012543 Applic. Date: 2009-02-16; KR20090042790 Applic. Date: 2009-05-15; KR20090062658 Applic. Date: 2009-07-09

Inventor: NAM JI-WON [KR]


Application No.: US20100166833A1  Published: 01/Jul/2010

Title: Compositions, articles and methods for preventing or reducing tobacco-associated damage

Applicant/Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD

Application No.: 12/588825   Filing Date: 29/Oct/2009

Abstract:Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.

Priority: WO2008IL00628 Applic. Date: 2008-05-06; US20080109191P Applic. Date: 2008-10-29; US20070924272P Applic. Date: 2007-05-07

Inventor: GAVISH MOSHE [IL]; NAGLER RAFAEL M [IL]


Application No.: US20100167178A1  Published: 01/Jul/2010

Title: Oxime sulfonates and the use thereof as latent acids

Applicant/Assignee:

Application No.: 12/308279   Filing Date: 15/Jun/2007

Abstract:Compounds of the formula (I), (II) or (III), wherein R1 is for example C1-C18alkylsulfonyl, C1-C10haloalkylsulfonyl, camphorylsulfonyl, phenyl-C1-C3alkylsulfonyl, phenylsulfonyl, naphthylsulfonyl, anthrylsulfonyl, phenanthrylsulfonyl or heteroarylsulfonyl, R'1 is for example phenylenedisulfonyl, R2 is for example CN, C1-C10haloalkyl or C1-C10haloalkyl which is substituted by (IV)

Ar1 is for example phenyl optionally substituted by a group of formula (IV)

Ar'1 is for example phenylene which optionally is substituted by a group of formula (IV)

A1, A2 and A3 independently of each other are for example hydrogen, halogen, CN, or C1-C18alkyl

D2 is for example a direct bond, O, (CO)O, (CO)S, SO2, OSO2 or C1-C18alkylene

or A3 and D2 together form C3-C30cycloalkenyl

or A2 and D2 together with the carbon of the ethylenically unsaturated double bond to which they are attached form C3-C30cycloalkyl

D3 and D4 for example independently of each other are a direct bond, O, S, C1-C18alkylene or C3-C30cycloalkylene provided that at least one of the radicals R2, Ar1 or Ar'1 comprises a group of the formula (IV)

are suitable as photolatent acid donors and for the preparation of corresponding polymers to be employed in chemically amplified photoresists.

Priority: EP20060115691 Applic. Date: 2006-06-20; WO2007EP55936 Applic. Date: 2007-06-15

Inventor: YAMATO HITOSHI [JP]; ASAKURA TOSHIKAGE [JP]; NISHIMAE YUICHI [JP]; IWAI TAKESHI [JP]; IRIE MAKIKO [JP]; NAKAYAMA KAZUHIKO [US]


Application No.: US20100167226A1  Published: 01/Jul/2010

Title: SYSTEM AND METHOD FOR DENTAL APPLICATIONS WITHOUT OPTICAL CONNECTORS IN CONSOLE, AND HANDPIECE ASSEMBLY THEREFOR

Applicant/Assignee: LASER ABRASIVE TECHNOLOGIES, LLC

Application No.: 12/644954   Filing Date: 22/Dec/2009

Abstract:The present invention is directed to systems and methods for dental applications that allow for cost effective, expedient surgical, microsurgical, cosmetic and diagnostics procedures. The system includes a console with no optical connector in it for high optical power and one or more handpiece assemblies detachably connected with the console via electrical connectors. The converter of electrical power to optical power is made as a semiconductor converter, such as a light emitting diode, a diode laser, a diode pumped solid state laser, a diode pumped fiber laser, and the like. The elements of the semiconductor converter in the embodiments of the invention are capable of being positioned in different parts of the handpiece assembly. In one embodiment, the console is adaptive and is capable of executing an executable code stored in a handpiece during its manufacture enabling corresponding performance of the system.

Priority: WO2008US68143 Applic. Date: 2008-06-25; US20070945994P Applic. Date: 2007-06-25

Inventor: ALTSHULER GREGORY B [US]; BELIKOV ANDREI V [RU]; FELDCHTEIN FELIX I [US]


Application No.: US20100167227A1  Published: 01/Jul/2010

Title: TOOTH WHITENING APPARATUS AND HEAD GEAR FOR TOOTH WHITENING APPARATUS

Applicant/Assignee:

Application No.: 12/676576   Filing Date: 04/Mar/2010

Abstract:Provided is a tooth whitening apparatus that allows a patient receiving tooth whitening treatment to move freely. By allowing a patient to wear the tooth whitening apparatus like a headphone, the patient is provided with the convenience of being able to move both hands freely and move around during tooth whitening treatment.

Priority: WO2007KR04353 Applic. Date: 2007-09-07

Inventor: JUN JONG-CHAN [KR]


Application No.: US20100167236A1  Published: 01/Jul/2010

Title: NON-PRESSURIZED SYSTEM FORE CREATING LIQUID DROPLETS IN A DENTAL CLEANING APPLIANCE

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 12/344852   Filing Date: 29/Dec/2008

Abstract:The appliance (10, FIG. 1) includes a body portion (27) and a nozzle portion (30) through which a spray of liquid droplets exits from a distal end thereof for cleaning of dental regions. The nozzle includes an orifice (36) at a proximal end thereof adjacent the body portion, as well as a pump (38) for moving liquid into an area of the nozzle just forward of the orifice. A mechanical system (12, 13, 14) is provided for moving a plunger or piston element (16) first away from the orifice under tension, such as a compression spring(24), and then controllably releasing the plunger or piston toward the orifice, the plunger/piston moving with sufficient force that atmospheric air which has been drawn into the appliance between the plunger or piston is forced through the orifice at a sufficiently high rate of speed to produce a spray of fluid droplets for dental cleaning when the moving air comes into contact with the liquid in the nozzle.

Priority:

Inventor: EDWARDS DAINIA [US]; KLOSTER TYLER G [US]; BENNING WOLTER F [US]


Application No.: US20100168228A1  Published: 01/Jul/2010

Title: NOVEL CHEMOTHERAPEUTIC AGENTS AGAINST INFLAMMATION AND CANCER

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD

Application No.: 12/528785   Filing Date: 12/Oct/2007

Abstract:Novel compounds, their methods of preparation and use in therapies related to cancer and inflammation are provided. Compounds comprise esters of cinnamic acid, vanillic acid and 4-hydroxy cinnamic acid and derivatives and salts thereof. Compounds with novel benzofuran lignan structure as a potent antimitotic agent and inducer of apoptosis are provided. Formulations and methods for treatment of diseases mediated by NF-kappaB are also provided.

Priority: IN2006MU01696 Applic. Date: 2006-10-13; WO2007IN00488 Applic. Date: 2007-10-12

Inventor: BOSE JULIE SAHA [IN]; GANGAN VIJAY [IN]


Application No.: US20100168798A1  Published: 01/Jul/2010

Title: BIOACTIVE COMPOSITES OF POLYMER AND GLASS AND METHOD FOR MAKING SAME

Applicant/Assignee:

Application No.: 12/577835   Filing Date: 13/Oct/2009

Abstract:The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.

Priority: US20080141453P Applic. Date: 2008-12-30

Inventor: CLINEFF THEODORE D [US]; DARMOC MARISSA M [US]; HAVENER MATTHEW B [US]; MURPHY JAMES P [US]; SZCZERBINSKI ZACHARY S [US]


Application No.: US20100170592A1  Published: 08/Jul/2010

Title: Device and Method for Filling Food Pots

Applicant/Assignee: A.R.C.I.L

Application No.: 12/652960   Filing Date: 06/Jan/2010

Abstract:The invention relates to a device (1) for filling food pots (2), for example yoghurt pots, comprising a plurality of nozzles (10) for filling the pots with a food product, said nozzles (10) each being mounted in a nozzle body (30), characterized in that the device comprises means for applying to each of the nozzles (10) a translational movement along the axis (A) of the nozzle, optionally combined with a rotational movement about this axis, independently of the nozzle body (30), in such a way that the same nozzle (10) can both carry out the filling action and stop the filling. The invention also relates to a method for filling food pots using a device of this type.

Priority: EP20090290006 Applic. Date: 2009-01-06

Inventor: LE ROI PAUL [FR]


Application No.: US20100172846A1  Published: 08/Jul/2010

Title: COMPOSITION AND METHOD OF BLEACHING TEETH

Applicant/Assignee: DEN-MAT HOLDINGS, LLC

Application No.: 12/708698   Filing Date: 19/Feb/2010

Abstract:Methods of using tooth bleaching gels with a high concentration of peroxide are disclosed. The present invention also provides a method for treating one or more teeth. The method includes steps of applying a desensitizing gel to one or more teeth, applying therapeutically effective amount of a tooth bleaching gel with a high concentration of peroxide to one or more teeth, and leaving the gel in contact with the one or more teeth such that the gel may whiten the tooth or teeth.

Priority: US2007-729929 Applic. Date: 2007-03-30; US20060787500P Applic. Date: 2006-03-31

Inventor: MATTHEWS ALAN B [US]


Application No.: US20100172847A1  Published: 08/Jul/2010

Title: ANTIMICROBIAL COMPOSITIONS CONTAINING LOW CONCENTRATIONS OF BOTANICALS

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 12/694119   Filing Date: 26/Jan/2010

Abstract:The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and optionally a solvent. The compositions of the invention may be used in personal care products such as creams or soap products.

Priority: US2009-367851 Applic. Date: 2009-02-09; WO2008US72006 Applic. Date: 2008-08-01; US20070953654P Applic. Date: 2007-08-02

Inventor: MODAK SHANTA [US]; BAIJU NAYANA [US]; CARAOS LAUSERPINA [US]


Application No.: US20100172848A1  Published: 08/Jul/2010

Title: SKIN AND SURFACE DISINFECTANT COMPOSITIONS CONTAINING BOTANICALS

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 12/694141   Filing Date: 26/Jan/2010

Abstract:The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.

Priority: WO2008US72006 Applic. Date: 2008-08-01

Inventor: MODAK SHANTA [US]; BAIJU NAYANA [US]; CARAOS LAUSERPINA [US]


Application No.: US20100172875A1  Published: 08/Jul/2010

Title: OIL-IN-WATER EMULSION AND ITS USE FOR THE DELAYED RELEASE OF ACTIVE ELEMENTS

Applicant/Assignee: NESTEC S.A

Application No.: 12/602339   Filing Date: 30/May/2008

Abstract:The present invention concerns the use of an oil-in-water emulsion where the interior of oil droplets exhibit interfaces, between lipophilic domains and hydrophilic or amphiphilic domains, due to the presence of a lipophilic additive solubilized inside the oil droplets and which is used for delayed release of active elements such that the release of at least one active element, which has a octanol/water partitioning coefficient logP higher than -1, corresponds to a higher Tmax than the Tmax obtained for the simple reference oil-in-water emulsion where no lipophilic additive is used.

Priority: WO2007EP55240 Applic. Date: 2007-05-30; WO2008EP56717 Applic. Date: 2008-05-30

Inventor: PHAN VAN ANH [CH]; GODINOT NICOLAS [CH]; SAGALOWICZ LAURENT [CH]; LESER MARTIN [CH]; ROBERT FABIEN [FR]


Application No.: US20100172945A1  Published: 08/Jul/2010

Title: EXTRUDED DELIVERY SYSTEM

Applicant/Assignee: FIRMENICH SA

Application No.: 12/663102   Filing Date: 13/Jun/2008

Abstract:A solid delivery system for an oily active ingredient, comprises an extrudate of a melt-emulsion wherein the continuous phase of the emulsion comprises a matrix material and the dispersed phase comprises an oily active material and an effective amount of a viscosity modifying ingredient such as ethyl cellulose.

Priority: US20070944927P Applic. Date: 2007-06-19; WO2008IB52335 Applic. Date: 2008-06-13

Inventor: GREGSON CHRISTOPHER [US]; SILLICK MATTHEW [US]


Application No.: US20100172949A1  Published: 08/Jul/2010

Title: CONSENSUS PEPTIDE

Applicant/Assignee: NUMAT AS

Application No.: 12/520651   Filing Date: 21/Dec/2007

Abstract:The present invention relates to artificial peptides optimized for the induction and/or stimulation of mineralization and/or biomineralization. The invention also relates to the use of these artificial peptides for the induction and/or stimulation of mineralization and/or biomineralization in vivo and in vitro.

Priority: US20060876149P Applic. Date: 2006-12-21; WO2007IB04068 Applic. Date: 2007-12-21

Inventor: LYNGSTADAAS STALE PETTER [NO]; ELLINGSEN JAN EIRIK [NO]


Application No.: US20100172993A1  Published: 08/Jul/2010

Title: PARTICLES FOR DELIVERY OF ACTIVE INGREDIENTS, PROCESS OF MAKING AND COMPOSITIONS THEREOF

Applicant/Assignee:

Application No.: 12/377185   Filing Date: 10/Aug/2007

Abstract:The present invention discloses compositions having particles comprising, inorganic element

one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.

Priority: IN2006MU01276 Applic. Date: 2006-08-11; IN2007MU00666 Applic. Date: 2007-04-03; WO2007IN00340 Applic. Date: 2007-08-10

Inventor: SINGH AMARJIT [IN]; SINGH SARABJIT [IN]; SINGH PARAMJIT [IN]; JAIN RAJESH [IN]


Application No.: US20100173009A1  Published: 08/Jul/2010

Title: SILICATE-SUBSTITUTED HYDROXYAPATITE

Applicant/Assignee:

Application No.: 12/652110   Filing Date: 05/Jan/2010

Abstract:An inorganic silicate-substituted calcium phosphate hydroxyapatite, useful as a biomaterial, has a Ca/P molar ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. The hydroxyapatite can be substantially free of carbonate ions. The material has relatively high solubility and is able to release silicon into solution.

Priority: GB20090000269 Applic. Date: 2009-01-08

Inventor: GIBSON IAIN RONALD [GB]; SKAKLE JANET MABLE SCOTT [GB]


Application No.: US20100173264A1  Published: 08/Jul/2010

Title: NANOSURFACE

Applicant/Assignee: ASTRA TECH AB

Application No.: 12/298884   Filing Date: 08/Jul/2008

Abstract:The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide

and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid

whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges

and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.

Priority: EP20070112076 Applic. Date: 2007-07-09; WO2008EP58860 Applic. Date: 2008-07-08

Inventor: FREDRIKSSON ANETTE [SE]; PETERSSON INGELA [SE]


Application No.: US20100173876A1  Published: 08/Jul/2010

Title: OIL-BASED NSAID COMPOSITIONS AND METHODS FOR MAKING AND USING SAME

Applicant/Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 12/512610   Filing Date: 30/Jul/2009

Abstract:A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration.

Priority: US2003-433454 Applic. Date: 2003-11-06; WO2001US51605 Applic. Date: 2001-12-19; US20000256711P Applic. Date: 2000-12-19; US20080137418P Applic. Date: 2008-07-30

Inventor: LICHTENBERGER LENARD M [US]; TIAN SHIQIANG [US]


Application No.: US20100173993A1  Published: 08/Jul/2010

Title: Controlled release biocidal salts

Applicant/Assignee:

Application No.: 12/658200   Filing Date: 04/Feb/2010

Abstract:A controlled release biocidal salt of a first component comprises a cation of a N[alpha]-(C1-C22)alkanoyl di-basic amino acid alkyl(C1-C22)ester cationic biocidal molecule and a second component comprising an anion of a monomeric anionic molecule having insignificant biocidal activity. The salt is characterized such that when the salt is exposed to an aqueous medium, the salt partially dissolves thereby releasing biocidal ions in an amount sufficient to exceed the MIC or MBC of a target bacteria being controlled, and further characterized as leaving a residual reservoir of undissolved salt capable of releasing more biocidal ions as the salt is consumed or otherwise removed from the environment encompassing the target bacteria. The preferred cationic biocidal molecule comprises N[alpha]-lauroyl-L-arginine ethyl ester ("LAE").

Priority: US2004-770248 Applic. Date: 2004-02-02; US2004-972567 Applic. Date: 2004-10-25; US2009-586695 Applic. Date: 2009-12-22; US20030445104P Applic. Date: 2003-02-06

Inventor: SAWYER ANTHONY J [US]; STOCKEL RICHARD F [US]


Application No.: US20100178252A1  Published: 15/Jul/2010

Title: PRODUCTS AND METHODS FOR DISCLOSING CONDITIONS IN THE ORAL CAVITY

Applicant/Assignee:

Application No.: 12/514613   Filing Date: 12/Nov/2007

Abstract:An oral composition capable of identifying a condition within the oral cavity by causing a visual contrast between the condition and the hard and soft tissues of the oral cavity has at least one disclosing agent. The disclosing agent can fluoresce in order to highlight conditions within the oral cavity.

Priority: US20060858504P Applic. Date: 2006-11-13; US20070932880P Applic. Date: 2007-06-01; WO2007IB54597 Applic. Date: 2007-11-12

Inventor: SAGEL PAUL ALBERT [US]; DIXON JR CLOYD [US]; KUNATH IVO [DE]; HAAS MARTIN [DE]; STOERKEL JENS UWE [DE]; TASCHOL ARMIN ANDREAS [AT]; ZIMMERMANN LUCY ABIGAIL [DE]; RAEHSE STEFFI [DE]


Application No.: US20100178278A1  Published: 15/Jul/2010

Title: FORMABLE BIOCERAMICS

Applicant/Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Application No.: 12/685743   Filing Date: 12/Jan/2010

Abstract:A formable bioceramic including hydroxyapatite nanocrystals, gelatin, and sol-gel-containing material is described. Also described is a process for making and using the bioceramic. The formable bioceramic displays superior mechanical strength, elasticity, biocompatibility and forming capabilities and is targeted for bone repairs and template-assisted tissue engineering applications.

Priority: WO2008US69923 Applic. Date: 2008-07-14; US20070949281P Applic. Date: 2007-07-12

Inventor: LUO TZY-JIUN MARK [US]; KO CHING-CHANG [US]; TULLOCH CAMILLA [US]


Application No.: US20100178353A1  Published: 15/Jul/2010

Title: QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON

Applicant/Assignee: BIOVAIL LABORATORIES INTERNATIONAL S.R.L

Application No.: 12/730339   Filing Date: 24/Mar/2010

Abstract:The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%

wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt

a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

Priority: US2002-176135 Applic. Date: 2002-06-21; US1998-179926 Applic. Date: 1998-10-27

Inventor: MEZAACHE NAIMA [US]; FRISBEE STEVEN E [US]; WOODALL PATRICK B [US]; HERMAN MARK R [US]


Application No.: US20100178630A1  Published: 15/Jul/2010

Title: Dental Tray

Applicant/Assignee:

Application No.: 12/687589   Filing Date: 14/Jan/2010

Abstract:The present invention is dental tray for applying treatment gels to a person's teeth. The dental tray is sized and shaped to accommodate the dental arch of a person's oral cavity and is constructed from a temperature-dependent material such that the dental arch forms to the shape of the person's teeth profile at temperatures at or above that of the person's oral cavity. Once the dental tray is fitted to the person's specific teeth profile, a treatment gel is applied to the dental tray, the dental tray reinserted and the treatment gel applied to the person's teeth by contact therewith. In one embodiment of the present invention, the treatment gel is applied to the unformed dental tray such that the dental tray is fitted to the person's teeth profile simultaneous with the treatment thereof.

Priority: US20090144573P Applic. Date: 2009-01-14

Inventor: NOVAK JONATHAN ERIK [US]; NOVAK THOMAS EDWIN [US]; NOVAK KEITH ADAM [US]


Application No.: US20100178634A1  Published: 15/Jul/2010

Title: DENTAL SANDING STRIP

Applicant/Assignee:

Application No.: 12/687177   Filing Date: 14/Jan/2010

Abstract:An improved dental sanding strip for removing material between the teeth is provided. The dental sanding strip includes a lead portion extending from one end of the dental sanding strip to facilitate the insertion of the strip into the space between the teeth. The dental sanding strip is an elongated strip of film having a first end and a second end. The first end having an abrasive portion and the second end having a holding portion. A lead portion extends from the first end, the area having the abrasive portion. The lead portion is affixed to the first end in a suitable manner such as with adhesive or by heat welding. The first end of the dental sanding strip is tapered toward the lead portion providing a gradual transition from the lead portion to the full width dental sanding strip. The lead portion of the dental sanding strip is inserted between the teeth by first inserting a free end of the lead portion into the space between the teeth. The dentist then grasps the lead portion and pulls the lead portion thereby permitting the abrasive portion of the dental sanding strip to contact the area on the tooth to be removed. The dentist may then manipulate the dental sanding strip to remove any unwanted material between the teeth. The dentist uses a back-and-forth motion, or a circular motion, to remove the unwanted material between the teeth.

Priority: US20090144538P Applic. Date: 2009-01-14

Inventor: DRALUS WENDY [US]


Application No.: US20100179243A1  Published: 15/Jul/2010

Title: Biodegradable Synthetic Bone Composites

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 12/633708   Filing Date: 08/Dec/2009

Abstract:The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component

such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Priority: WO2008US66346 Applic. Date: 2008-06-09; US20070942988P Applic. Date: 2007-06-08

Inventor: LIU GAO [US]; ZHAO DACHENG [CN]; SAIZ EDUARDO [GB]; TOMSIA ANTONI P [US]


Application No.: US20100179244A1  Published: 15/Jul/2010

Title: Total etch dental adhesive composition

Applicant/Assignee: DENTSPLY INTERNATIONAL INC

Application No.: 12/319949   Filing Date: 13/Jan/2009

Abstract:Dental adhesive composition having a pH of at least 5, which comprises an aqueous solution containing (a) a polymerizable N-substituted alkyl acrylic or acrylic acid amide monomer

(b) a water-soluble polymerizable carboxylic acid

and (c) a water-soluble organic solvent.

Priority:

Inventor: KLEE JOACHIM E [DE]; LEHMANN UWE [DE]


Application No.: US20100179665A1  Published: 15/Jul/2010

Title: IMPLANT, IN PARTICULAR DENTAL IMPLANT

Applicant/Assignee:

Application No.: 12/377218   Filing Date: 17/Aug/2007

Abstract:A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Priority: CH20060001339 Applic. Date: 2006-08-22; WO2007CH00402 Applic. Date: 2007-08-17

Inventor: SCHLOTTIG FALKO [CH]; SNETIVY DANIEL [CH]


Application No.: US20100180397A1  Published: 22/Jul/2010

Title: Dirt-collecting device for a floor-cleaning machine, and floor-cleaning machine having such a dirt-collecting device

Applicant/Assignee: ALFRED KAERCHER GMBH & CO. KG

Application No.: 12/657293   Filing Date: 15/Jan/2010

Abstract:The invention relates to a dirt-collecting device for a floor-cleaning machine, for picking up a liquid from a floor surface which is to be cleaned, having a carrier and at least one wiping member for wiping the floor surface, the carrier and the at least one wiping member bounding a suction channel which opens out into a suction mouth and of which the free cross-sectional area, through which a suction stream can pass, decreases, at least in one channel portion, in a direction away from the suction mouth. In order to produce such a dirt-collecting device in a more cost-effective manner, it is proposed according to the invention that the suction channel has disposed in it at least one channel-narrowing member, which is produced separately from the carrier. The invention also relates to a floor-cleaning machine having such a dirt-collecting device.

Priority: DE200710034702 Applic. Date: 2007-07-18; WO2008EP05008 Applic. Date: 2008-06-20

Inventor: SCHUETZ MICHAEL [DE]; KOLBECK FLORIAN [DE]; DE SILVA RUWANTHA [DE]


Application No.: US20100180912A1  Published: 22/Jul/2010

Title: COATED MULTI-RIBBED DENTAL TAPE

Applicant/Assignee:

Application No.: 12/748723   Filing Date: 29/Mar/2010

Abstract:The present invention includes coated monofilament dental tapes for removing plaque and/or food debris from interdental spaces of a mammal, which dental tapes have a core body with an aspect ratio of about 5:1 or greater, a first cleaning surface and a second cleaning surface opposite the first cleaning surface, a plurality of ribs disposed along the length of each cleaning surface, and a coating containing about 0.8 milligram per yard of dental tape or more of an abrasive and about 0.8 milligram per yard dental tape or more of sodium bicarbonate.

Priority: US2008-184067 Applic. Date: 2008-07-31; US2007-937025 Applic. Date: 2007-11-08

Inventor: OCHS HAROLD D [US]; PANNIA JOSEPH [US]


Application No.: US20100181216A1  Published: 22/Jul/2010

Title: CAPSULE FOR CONTAINING A CONCENTRATED PRODUCT TO BE USED DILUTED IN A SOLUTION AND BOTTLE FOR CONTAINING SAID SOLUTION PROVIDED WITH THIS CAPSULE

Applicant/Assignee:

Application No.: 12/665825   Filing Date: 20/Jun/2008

Abstract:A capsule for containing a concentrated product to use diluted in a solution contained inside a bottle. This capsule is suitable to be secured to the body of said bottle and is also provided with an undercap (10) suitable to cooperate with a corresponding wall (6) of said capsule (1), so as to form a chamber (8) for containing said concentrated product. With respect to prior art bottles, the bottle according to the invention allows the detergent, disinfectant or other solution to be prepared directly at the time of use, thereby preventing degradation thereof during the storage period.

Priority: IT2007MI01266 Applic. Date: 2007-06-22; WO2008EP57853 Applic. Date: 2008-06-20

Inventor: MELIS GIUSEPPE [IT]; MELIS VALENTINA [IT]; MELIS ALESSANDRA [IT]; MELIS STEFANIA [IT]; MELIS NICOLA [IT]


Application No.: US20100183524A1  Published: 22/Jul/2010

Title: ANTIOXIDANT COMPOSITIONS FOR SOFT ORAL TISSUE AND METHODS OF FORMULATION AND USE THEREOF

Applicant/Assignee: PERIO SCIENCES, LLC

Application No.: 12/623132   Filing Date: 20/Nov/2009

Abstract:One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrocurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrocurcuminoids CG(TM), or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above.

Priority: US20080118253P Applic. Date: 2008-11-26; US20090247356P Applic. Date: 2009-09-30

Inventor: ZIELINSKI JAN [US]; MOON THOMAS RUSSELL [US]; ALLEN EDWARD P [US]


Application No.: US20100183740A1  Published: 22/Jul/2010

Title: Potent Inhibitory Effect of Zinc in Combination with Sulforaphane on Cancer Cell Growth

Applicant/Assignee: UNIVERSITY OF MARYLAND, BALTIMORE

Application No.: 12/690432   Filing Date: 20/Jan/2010

Abstract:This invention relates to compositions comprising zinc and sulforaphane which can be used in the treatment or prevention of cancer. The invention also relates to methods of treating or preventing cancer, including prostate cancer, which comprises the administration of zinc and sulforaphane to a patient in need thereof.

Priority: US20090146342P Applic. Date: 2009-01-22

Inventor: FENG PEI [US]


Application No.: US20100183999A1  Published: 22/Jul/2010

Title: CURABLE DENTAL RETRACTION COMPOSITION, METHOD OF PRODUCTION AND USE THEREOF

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/376527   Filing Date: 02/Aug/2007

Abstract:The invention relates to a curable dental retraction composition for reacting gingiva from a prepared tooth structure. The composition comprises an alginate, a di- and/or trivalent ion source, water, a retarder and a filler.

Priority: EP20060016477 Applic. Date: 2006-08-08; WO2007US75065 Applic. Date: 2007-08-02

Inventor: KLETTKE THOMAS [DE]; HAMPE RUEDIGER [DE]


Application No.: US20100184654A1  Published: 22/Jul/2010

Title: ANTI-MICROBIAL TARGETING CHIMERIC PHARMACEUTICAL

Applicant/Assignee:

Application No.: 12/363675   Filing Date: 30/Jan/2009

Abstract:The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e.g., on mucosal surfaces by using the compositions provided by the present invention.

Priority: US2003-706391 Applic. Date: 2003-11-12; US2002-077624 Applic. Date: 2002-02-14; US2001-910358 Applic. Date: 2001-07-19; US1999-378577 Applic. Date: 1999-08-20

Inventor: ECKERT RANDAL [US]; QI FENGXIA [US]; SHI WENYUAN [US]; ANDERSON MAXWELL H [US]


Application No.: US20100184670A1  Published: 22/Jul/2010

Title: ANTISENSE COMPOSITIONS AND METHODS FOR MODULATING CONTACT HYPERSENSITIVITY OR CONTACT DERMATITIS

Applicant/Assignee:

Application No.: 12/641159   Filing Date: 17/Dec/2009

Abstract:Provided are methods and compositions, including topical compositions, for inducing tolerance to a sensitizing agent known to provoke contact hypersensitivity in a subject. Included are methods of topically applying to the subject an effective amount of an antisense composition targeting the start site or splice site of a CFLAR mRNA.

Priority: US20080138460P Applic. Date: 2008-12-17

Inventor: MOURICH DAN V [US]; MARSHALL NIKKI B [US]; IVERSEN PATRICK L [US]


Application No.: US20100184802A1  Published: 22/Jul/2010

Title: Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof

Applicant/Assignee:

Application No.: 12/225340   Filing Date: 16/Mar/2007

Abstract:Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20060783748P Applic. Date: 2006-03-16; US20060831416P Applic. Date: 2006-07-17; US20060846993P Applic. Date: 2006-09-25; US20060875109P Applic. Date: 2006-12-15; US20070918260P Applic. Date: 2007-03-15; WO2007US06747 Applic. Date: 2007-03-16

Inventor: KELLY MICHAEL G [US]; KINCAID JOHN [US]; FANG YUNFENG [US]; CAO YEYU [US]; KAUB CARL [US]; GOWLUGARI SUMITHRA [US]; WANG ZHAN [US]


Application No.: US20100184863A1  Published: 22/Jul/2010

Title: SYNTHETIC SPILANTHOL AND USE THEREOF

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 12/505283   Filing Date: 17/Jul/2009

Abstract:The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E, 6E, 8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E, 6Z, 8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

Priority: JP20080009295 Applic. Date: 2008-01-18; JP20080009821 Applic. Date: 2008-01-18; JP20080009832 Applic. Date: 2008-01-18; JP20080009851 Applic. Date: 2008-01-18; WO2009JP50566 Applic. Date: 2009-01-16; US20090174141P Applic. Date: 2009-04-30

Inventor: LOMBARDO LOUIS [US]; LANKIN MICHAEL E [US]; ISHIDA KENYA [JP]; TANAKA SHIGERU [JP]; UJIHARA HIDEO [JP]; YAGI KENJI [JP]; MEI JENNIFER B [US]; GREEN CARTER B [US]; MANKOO AMRIT S [US]


Application No.: US20100184866A1  Published: 22/Jul/2010

Title: Dual Cation Dual Anion Coordination Complexes

Applicant/Assignee: MISSION PHARMACAL COMPANY

Application No.: 12/651927   Filing Date: 04/Jan/2010

Abstract:Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table

B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions

A and B are different

"Cit" is tribasic citric acid anion

the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0

m is 0-12

and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.

Priority: US20090146572P Applic. Date: 2009-01-22

Inventor: WALTER MARY ANN [US]; GAO JIAN [US]; WALSDORF NEILL BAILEY [US]


Application No.: US20100184921A1  Published: 22/Jul/2010

Title: Process for producing resin composition and process for producing molded article

Applicant/Assignee: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

Application No.: 12/656500   Filing Date: 01/Feb/2010

Abstract:A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material.

Priority: JP20050013231 Applic. Date: 2005-01-20; US2007-795502 Applic. Date: 2007-07-18; WO2006JP300772 Applic. Date: 2006-01-19

Inventor: TANAKA JIRO [JP]; SUZUKI KAZUOMI [JP]


Application No.: US20100185293A1  Published: 22/Jul/2010

Title: LAYER ARRANGED ON IMPLANT FOR BONE OR TISSUE STRUCTURE, SUCH AN IMPLANT, AND A METHOD FOR APPLICATION OF THE LAYER

Applicant/Assignee: NOBEL BIOCARE AB (PUBL.)

Application No.: 12/748867   Filing Date: 29/Mar/2010

Abstract:A layer is arranged on an implant for bone or tissue structure. The layer constitutes a boundary or barrier between the actual or unoxidized body of the implant and the structure for the purpose of increasing retention and has, in this context, a substantial thickness. The layer is designed with a channel network which gives the layer a substantial porosity. The channel network is designed with mouths which face towards the structure and whose respective cross-sectional diameters, at the surface of the layer facing towards the structure, are substantially less than the respective extents of the channels in and down into the layer as seen from the said surface.

Priority: SE19990001974 Applic. Date: 1999-05-31; US2002-980006 Applic. Date: 2002-05-09; WO2000SE01026 Applic. Date: 2000-05-23

Inventor: HALL JAN [SE]; LAUSMAA JUKKA [SE]


Application No.: US20100186179A1  Published: 29/Jul/2010

Title: RECIPROCATING WORKPIECE DEVICE WITH A DRIVE SYSTEM SEEKING THE RESONANCE OF THE DRIVEN SYSTEM PORTION THEREOF

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 11/993744   Filing Date: 30/Jun/2006

Abstract:A workpiece system with a reciprocating motion which includes a motor assembly for producing an output drive signal with a periodic force pulse. The drive signal is coupled to a driven member assembly through a magnetic arrangement, wherein the driven member assembly has a workpiece mounted thereon with a return spring assembly. The driven member assembly has a resonant mechanical frequency. As the RPM of the motor increases from zero following startup, the drive signal frequency increases to the point very near resonance, where the energy from the drive signal is transferred into the reciprocating motion of the driven assembly, producing an effective amplitude of workpiece motion.

Priority: US20050695659P Applic. Date: 2005-06-30; WO2006IB52214 Applic. Date: 2006-06-30

Inventor: MILLER KEVIN [US]; PACE JOHN [US]; HEADSTROM PATRICK [US]; BENNING WOLTER [NL]


Application No.: US20100186771A1  Published: 29/Jul/2010

Title: PORTABLE DUSTING TOOL

Applicant/Assignee:

Application No.: 12/756444   Filing Date: 08/Apr/2010

Abstract:There is provided a non-scrubbing dusting tool for cleaning the exposed surface of a digital camera sensor lens in a recessed digital camera sensor chamber. The dusting tool comprises a dust brush having an elongated shank with a tuft of bristles having electrostatic charge built up therein at one end, and a handle at the other end. The tuft of bristles is V-shape and its free end tips are bevelled, for best performance. The duster is sized to adjustably fit inside the digital camera sensor chamber in such a fashion that the bristles leading edge tips will be able to reach all of the exposed surface of the camera sensor lens while avoiding contaminating contact with the camera sensor chamber. In an operative sensor lens cleaning condition of the dusting tool, the dust brush remains motionless relative to the handle while the dusting tool bristles leading edge tips are manually swept over the camera sensor lens to be cleaned. When the dusting tool is not in use, a rotating motor may spin the dust brush so that the bristles fan out under centrifugal force, so as to remove dust collected by the bristles during cleaning operations.

Priority: US2007-813471 Applic. Date: 2007-07-06; WO2006CA00907 Applic. Date: 2006-06-02

Inventor: RAHBAR-DEHGHAN FARIBORZ [CA]


Application No.: US20100186923A1  Published: 29/Jul/2010

Title: APPARATUS FOR PREPARING ALLOY SHEET

Applicant/Assignee:

Application No.: 12/668511   Filing Date: 28/May/2008

Abstract:Apparatus for preparing alloy sheet, comprising a container for melted alloy liquid positioned in an inductive heating coil

a liquid flow stabilization outfit comprising a barrel container with open bottom and a base board arranged below the open bottom, and the barrel container's upper part being positioned below the mouth of the container for melted alloy liquid

a quenching wheel positioned below the melted alloy liquid flown from the liquid flow stabilization outfit's base board, which carries the melted alloy liquid and spins it into strips, so as to make the strips become alloy sheets after collision

a transferring outfit positioned below the wheel for further cooling and transferring of the alloy sheets, characterized in that the quenching wheel is equipped with a means for differentiating cooling rate for various alloy sheets. The apparatus for preparing alloy sheets of this invention can produce rare earth-transition metal alloy sheets at different cooling rates, and make a proper distribution of grain size. The magnetic material made of these alloy sheets is good in orientation, easy for post-sinter processing, and suitable for mass production.

Priority: CN20071118723 Applic. Date: 2007-07-12; WO2008CN71111 Applic. Date: 2008-05-28

Inventor: HU BOPING [CN]; WANG YIZHONG [CN]; RAO XIAOLEI [CN]; JIA JINGDONG [CN]


Application No.: US20100188765A1  Published: 29/Jul/2010

Title: Oxime Ester Photoinitiators

Applicant/Assignee:

Application No.: 12/086567   Filing Date: 09/Nov/2006

Abstract:Compounds of the Formula (I) and (II) wherein M1, M2 and M3 independently of one another are no bond, a direct bond, CO, O, S, SO, SO2 or NR14

provided that at least one of M1, M2 or M3 is a direct bond, CO, O, S, SO, SO2 or NR14

M4 is a direct bond, CR''3R''4, CS, O, S, SO, or SO2

Y is S or NR18

R1 for example is hydrogen, C3-C8cycloalkyl, phenyl or naphthyl, both of which are optionally substituted

R2 for example is C1-C20alkyl

R''2 has one of the meanings given for R2

R3 and R4 are for example hydrogen, halogen, C1-C20alkyl

R'3, R'4, R''3 and R''4 independently of one another have one of the meanings given for R3 and R4

and R5 is for example hydrogen, halogen, C1-C20alkyl

provided that in the compounds of the Formula (I) at least two oxime ester groups are present

exhibit an unexpectedly good performance in photopolymerization reactions.

Priority: EP20050112439 Applic. Date: 2005-12-20; EP20060115428 Applic. Date: 2006-06-14; WO2006EP68254 Applic. Date: 2006-11-09

Inventor: MATSUMOTO AKIRA [JP]; TANABE JUNICHI [JP]; KURA HISATOSHI [JP]; OHWA MASAKI [JP]


Application No.: US20100189663A1  Published: 29/Jul/2010

Title: MOUTH RINSE COMPOSITIONS INCLUDING CHEMICALLY MODIFIED SILICA OR SILICATE MATERIALS FOR SUSTAINED DELIVERY TO TOOTH SURFACES

Applicant/Assignee:

Application No.: 12/648673   Filing Date: 29/Dec/2009

Abstract:Novel mouth rinse (i.e., mouthwash) compositions that permit delivery of silica or silicate materials to the surface of teeth through common mouth rinsing procedures are provided. Such compositions must exhibit proper suspension of the silica or silicate materials (in particulate form) to prevent settling during storage while simultaneously providing proper mouth rinsing properties. Such silica or silicate materials may themselves exhibit any number of therapeutic or aesthetic benefits as long as such materials are easily transferred through mouth rinsing and exhibit proper affinity for deposit on target teeth upon contact therewith. Such silica or silicate materials should exhibit, in one embodiment, certain ionic charge levels as well as sufficiently small particle sizes to permit effective static attraction and eventual accumulation on target tooth surfaces. Methods of utilizing such mouthwashes for breath freshening and/or cleaning, as well as silica or silicate material tooth accumulation, are encompassed within this invention as well.

Priority: US20090275689P Applic. Date: 2009-01-24

Inventor: GALLIS KARL W [US]; SWAZEY JR JOHN MCARTHUR [US]; PASAY COZETTE ASHLY B [US]; DARSILLO MICHAEL S [US]; ZAPF JASON THOMAS [US]


Application No.: US20100189729A1  Published: 29/Jul/2010

Title: RNA-CODED ANTIBODY

Applicant/Assignee: CURVAC GMBH

Application No.: 12/522214   Filing Date: 08/Jan/2008

Abstract:The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of a pharmaceutical composition, in particular a passive vaccine, for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, auto-immune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention furthermore describes an in vitro transcription method, in vitro methods for expression of this antibody using the RNA according to the invention and an in vivo method.

Priority: DE200710003370 Applic. Date: 2007-01-09; WO2008EP00081 Applic. Date: 2008-01-08

Inventor: HOERR INGMAR [DE]; PROBST JOCHEN [DE]; PASCOLO STEVE [CH]


Application No.: US20100189808A1  Published: 29/Jul/2010

Title: SPUTUM DISSOLVING SUCTIONING SOLUTION FOR ENDOTRACHEAL AND TRACHEOSTOMY TUBES

Applicant/Assignee: TELEFLEX MEDICAL INCORPORATED

Application No.: 12/693753   Filing Date: 26/Jan/2010

Abstract:A composition for dissolving or reducing the viscosity of sputum on a surface of a device includes an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution. The effective amount of glycerol is between about 30-50% and the effective amount of dextran sulfate is between about 10-30%. The composition may further include an antimicrobial agent.

Priority: US20090147658P Applic. Date: 2009-01-27; US20090150488P Applic. Date: 2009-02-06

Inventor: GUPTA NISHA [US]; PETERS ERIN [US]; ROSENBLATT JOEL [US]


Application No.: US20100189861A1  Published: 29/Jul/2010

Title: SWEETNER AND USE

Applicant/Assignee: PURECIRCLE SDN BHD

Application No.: 12/684129   Filing Date: 08/Jan/2010

Abstract:Sweeteners on the basis of a simultaneously transglucosylated sweet glycoside mixture of Stevia rebaudiana Bertoni are prepared. The transglucosylation was developed in the presence of starch under the action of cyclodextrin glucanotransferase. The remaining maltodextrins are transformed to the fructose-terminated oligosaccharides by the addition of sucrose. The sweeteners are purified to not less than 98% content of sweet glycosides and derivatives. The preparations are almost non-caloric, non-cariogenic, non-bitter, non-lingering sweeteners, which may be advantageously applied in foods, beverages, cosmetics and milk products.

Priority: US2005-246066 Applic. Date: 2005-10-11

Inventor: ABELYAN VARUZHAN [MY]; MARKOSYAN AVETIK [MY]; ABELYAN LIDIA [MY]


Application No.: US20100190180A1  Published: 29/Jul/2010

Title: Materials and Methods for Screening, Diagnosis and Prognosis of Conditions Associated With Stat Protein Expression

Applicant/Assignee:

Application No.: 11/988315   Filing Date: 06/Jul/2006

Abstract:The subject invention concerns methods and materials for cancer screening using platinum complexes to detect a STAT protein biomarker. Platinum (IV) complexes interacting with STATs directly correlate with the STAT expression. In one embodiment, fluorescently-labeled and/or antibody-linked platinum (IV) complexes can be used to assess the STAT expression and define malignant potential. Other methods such as imaging (MRI, e.g.) can also be used to assess platinum-STAT interactions. The STAT protein can be, for example, STAT3.

Priority: US20050696742P Applic. Date: 2005-07-06; WO2006US26401 Applic. Date: 2006-07-06

Inventor: KAY HEIDI [US]


Application No.: US20100190821A1  Published: 29/Jul/2010

Title: 3,8-SUBSTITUTED 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/727972   Filing Date: 19/Mar/2010

Abstract:This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20050000068 Applic. Date: 2005-01-13; US2007-794365 Applic. Date: 2007-06-28; WO2006EP50143 Applic. Date: 2006-01-11; US20050643590P Applic. Date: 2005-01-14

Inventor: PETERS DAN [SE]; DAHL BJARNE H [DK]; OLSEN GUNNAR M [DK]; NIELSEN ELSEBET OSTERGAARD [DK]; SCHEEL-KRUGER JORGEN [DK]; REDROBE JOHN PAUL [DK]


Application No.: US20100191159A1  Published: 29/Jul/2010

Title: Vibration Pad Cover and Vibration Treatment System

Applicant/Assignee: VIBRANT MEDICAL LIMITED

Application No.: 12/598594   Filing Date: 02/May/2008

Abstract:A cover (150) for a vibratory pad (10) comprises a pocket or pouch (158) faced with dressing fabric material and sized to accommodate a vibration pad, a closure (154e) to retain the cover on the pad, in use, and a strap (146,148) integral with the cover suitable for connecting the cover (and a pad retained therein) to the limb (29) of a patient. The strap has an (adhesive) connector (176) that is capable of being secured so as to pressure the pad against the limb and so that, once made, the connection cannot be unmade without disabling the connector against making subsequent connections. Thus the cover can only be used once. A system (12'150') includes the vibration device and comprises means to disable the device after a cover has been employed for a period of time or number of treatments.

Priority: GB20070008575 Applic. Date: 2007-05-03; WO2008GB50324 Applic. Date: 2008-05-02

Inventor: ELLIN PHILIP JAMES [GB]


Application No.: US20100192972A1  Published: 05/Aug/2010

Title: Flossing Device

Applicant/Assignee:

Application No.: 12/666708   Filing Date: 26/Jun/2008

Abstract:Provided is a flossing device comprising a dental floss in the shape of the numeral eight, the device not only entering between the teeth, but adjoining to and cleaning the whole teeth-surface surrounding the inter proximal space. The floss of the device may be impregnated with cosmetic or medical agents.

Priority: US20070946732P Applic. Date: 2007-06-28; WO2008IL00881 Applic. Date: 2008-06-26

Inventor: KAZES EREZ BENN [IL]


Application No.: US20100193073A1  Published: 05/Aug/2010

Title: APPARATUS AND METHOD FOR PRODUCING PET BULK RECEPTACLES

Applicant/Assignee: KRONES AG

Application No.: 12/699530   Filing Date: 03/Feb/2010

Abstract:A method for producing containers filled with liquids, wherein the containers are filled with the liquid and closed with a keg fitting, includes supplying the keg fitting to the container by means of a relative movement between the container and the keg fitting and connecting the keg fitting with the container. A cleaning treatment of the keg fitting is carrier out at least prior to or during the supply process or the connection process.

Priority: DE200910007327 Applic. Date: 2009-02-03

Inventor: MEINZINGER RUPERT [DE]


Application No.: US20100193391A1  Published: 05/Aug/2010

Title: CARDBOARD/PLASTIC COMPOSITE PACKAGING HAVING A PULL-OFF COVER, AND A METHOD AND DEVICE FOR THE PRODUCTION THEREOF

Applicant/Assignee: SIG TECHNOLOGY AG

Application No.: 12/373630   Filing Date: 13/Jul/2007

Abstract:The invention relates to a composite card/plastics package comprising a package main body (8) which is provided with a longitudinal seam (6) and having a folded and welded package floor (18) which is provided at one end (16) of the package main body (8), and to a method and apparatus for producing it, in the case of which package the object of specifying a composite card/plastics package which is also suitable for non-liquid products and can moreover be stacked satisfactorily is achieved by arranging at the top end (11) of the package main body (8) a ledge (10) which extends round it and fastening a lid (14/L) to the ledge (10) in such a way that the lid (14/L) is able to be pulled off.

Priority: DE200610032638 Applic. Date: 2006-07-13; WO2007EP57277 Applic. Date: 2007-07-13

Inventor: DAMMERS MATTHIAS [DE]; VIERBOOM WERNER [DE]; BIRNINGER BIRGIT [DE]; BERGER JORG [DE]; KONZE ACHIM [DE]


Application No.: US20100193463A1  Published: 05/Aug/2010

Title: Seal For A Container

Applicant/Assignee:

Application No.: 12/665239   Filing Date: 19/Jun/2008

Abstract:A seal for a container for comestibles, especially portable liquids, and in particular for use for sealing polyester containers such as bottles, which is suitable for passage through a PET recycling process, comprises a metal foil layer, a foam layer and a plastics film layer as well as a heat sealable layer below the foil. The foam is selected for its density and thickness so is to confer upon the seal a high buoyancy. The adhesion a between the foam and the foil is increased compared to currently available products, in order to prevent de-lamination between the foil and the foam during the recycling process.

Priority: EP20070110921 Applic. Date: 2007-06-22; WO2008US67445 Applic. Date: 2008-06-19

Inventor: O'BRIEN DAVID JOHN [GB]; SACHS VICTOR [GB]; MCLEAN ANDREW FENWICK [GB]


Application No.: US20100193545A1  Published: 05/Aug/2010

Title: Tube Roller Dispenser

Applicant/Assignee:

Application No.: 12/327744   Filing Date: 03/Dec/2008

Abstract:The device is a mechanism for dispensing the contents of a collapsible tube. The invention contains a narrow slot inside a body for inserting the end of a tube. A knob is located to the side, which when turned causes the tube to wrap around the body, expelling contents of the tube. A rod is attached to the body on each side of the tube with two loops. The loops allow the rod to remain still while the main body is turned. Once the desired quantity is dispensed, this rod prevents to the tube from unwinding. The rod also guides the tube to prevent it from wrapping to one side. In addition, when the contents are expelled, the rod can be held while the tube is pulled out. The body will spin, unwinding the tube.

Priority:

Inventor: CIENFUEGOS VINCENT JOSEPH ROBERT [US]


Application No.: US20100194005A1  Published: 05/Aug/2010

Title: METHOD AND APPARATUS FOR MANUFACTURING SLABS WITH VEINED EFFECT

Applicant/Assignee:

Application No.: 12/669121   Filing Date: 04/Jul/2008

Abstract:During the manufacture of slabs with a veined effect a liquid or powder colouring agent is deposited on the surface of a thin layer of starting mixture by means of at least one dispensing device (40) and the resultant mixture is supplied, falling freely, from one end of an extractor belt (30) forming the bottom of a mixture metering/distributor unit, following which the mixture is transferred, falling freely, onto a temporary moulding support (14). This results in the production of slabs provided with veining extending through the entire thickness of the slabs and also visible along the whole edge of the slab, even after it has been machined.

Priority: IT2007TV00126 Applic. Date: 2007-07-16; WO2008EP58682 Applic. Date: 2008-07-04

Inventor: TONCELLI LUCA [IT]


Application No.: US20100194409A1  Published: 05/Aug/2010

Title: METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE

Applicant/Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Application No.: 12/377404   Filing Date: 14/Aug/2007

Abstract:The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.

Priority: US20060838036P Applic. Date: 2006-08-16; WO2007SG00251 Applic. Date: 2007-08-14

Inventor: GAO ZHIQIANG [SG]; FAN YI [SG]; CHEN XIANTONG [SG]; KONG JINMING [SG]


Application No.: US20100196286A1  Published: 05/Aug/2010

Title: INHALATION DELIVERY METHODS AND DEVICES

Applicant/Assignee:

Application No.: 12/628951   Filing Date: 01/Dec/2009

Abstract:Methods, devices and kits for treating sleep disorders, anxiety disorders, and developmental disorders, and/or for inducing an arousable state of sedation in a subject, are described. For example, inhalation methods, devices and kits for treating insomnia, anxiety and/or ADHD using one or more [alpha]2-adrenergic agonists such as dexmedetomidine or clonidine are described.

Priority: US20080119015P Applic. Date: 2008-12-01

Inventor: ARMER THOMAS A [US]; COOK ROBERT O [US]; ALFREDSON TERRY [US]; SUN ANTHONY [US]


Application No.: US20100196297A1  Published: 05/Aug/2010

Title: Urine as a source of alternative cellular energy pigments (ACE-pigments) in the Assesment and therapy of diseases

Applicant/Assignee:

Application No.: 12/381003   Filing Date: 05/Mar/2009

Abstract:Alternative cellular energy pigments (ACE-pigments) are over-produced in response to various types of viral infections and to other pathological conditions. ACE pigments accumulate at the sites of disease and also in other regions of the body, including the oral cavity. ACE pigments are considered to play a significant role in the body's healing response to both local and system diseases. They appear to exist in a relatively inactive form in which they can fluorescence under ultraviolet (UV) light illumination, especially if stained with a suitable dye, such as neutral red. The present invention describes a method of using ACE pigments collected from the urine of patients for the purpose of activating the patient's ACE pathway in a child with autism, with an extrapolation to patients with a wide variety of other infectious and non-infectious illnesses for which there is a presumed or shown insufficiency of cellular energy. Urine or urine-derived material containing the collected ACE pigments is placed onto a suitable material, such as a paper towel, stained with neutral red dye and induced to fluoresce using UV illumination. The fluorescing mixture is placed over various areas of the body and/or directly placed over a localized skin lesion and the UV illumination continued. This process will assist in the local as well as overall activation of the ACE pathway in the patient with resulting clinical benefit.

Priority: US2009-322491 Applic. Date: 2009-02-02

Inventor: MARTIN WILLIAM JOHN [US]


Application No.: US20100196478A1  Published: 05/Aug/2010

Title: PROTEIN MATRIX MATERIALS, DEVICES AND METHODS OF MAKING AND USING THEREOF

Applicant/Assignee: GEL-DEL TECHNOLOGIES, INC

Application No.: 12/700896   Filing Date: 05/Feb/2010

Abstract:The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

Priority: US2001-796170 Applic. Date: 2001-02-28; US1998-160421 Applic. Date: 1998-09-25

Inventor: MASTERS DAVID B [US]


Application No.: US20100196514A1  Published: 05/Aug/2010

Title: CALCIUM SILICATE-BASED COMPOSITE CEMENT AND METHODS FOR THE PREPARATION

Applicant/Assignee: CHUNG SHAN MEDICAL UNIVERSITY

Application No.: 12/364278   Filing Date: 02/Feb/2009

Abstract:The present invention provides a method for producing calcium silicate-based bone cement and a composition produced by the method. It further provides a novel composition for bone tissue repair.

Priority:

Inventor: DING SHINN-JYH [TW]


Application No.: US20100196524A1  Published: 05/Aug/2010

Title: NOVEL PEPTIDES AND METHODS FOR PRODUCING THEM

Applicant/Assignee: VALIO LTD

Application No.: 12/364128   Filing Date: 02/Feb/2009

Abstract:The present invention relates to the fields of life sciences and food, feed or pharmaceutical industry. Specifically, the invention relates to novel peptides, pilus structures, polynucleotides as well as vectors, host cells, products and pharmaceutical compositions comprising the polynucleotides, peptides or pilus structures. The invention also relates to gene clusters and antibodies. Furthermore, the present invention relates to methods for producing the peptides or pilus structures or producing the products comprising the peptides or pilus structures. Furthermore, the present invention relates to treatments as well as uses and methods for screening bacterial strains, for reducing or inhibiting the adhesion of pathogenic bacteria, promoting the adhesion of bacterial cells to the mucus and for modifying immune response in a subject. Still, the present invention relates to methods for detecting probiotic bacterial strains or pathogen strains.

Priority:

Inventor: MEINDERT DE VOS WILLEM [NL]; PALVA AIRI [FI]; PALVA ILKKA [FI]; REUNANEN JUSTUS [FI]; VON OSSOWSKI INGEMAR [FI]; SATOKARI REETTA [FI]; VESTERLUND SATU [FI]; KANKAINEN MATTI [FI]; SALUSJARVI TUOMAS [FI]; TYNKKYNEN SOILE [FI]


Application No.: US20100196856A1  Published: 05/Aug/2010

Title: METHOD OF MAKING AN ORAL PROSTHESIS

Applicant/Assignee:

Application No.: 12/362608   Filing Date: 30/Jan/2009

Abstract:A method of rapidly making an oral prosthesis with minimal steps and materials is disclosed. The method generally includes the steps of (1) providing a cast of an oral cavity or portion thereof

(2) applying a setting material along one or more setting zones where teeth are absent from the cast subject's oral cavity

(3) engaging one or more prosthetic teeth with the setting material on the cast

(4) applying a self-curing composition along the outward facing surface(s) of the setting material and a portion of the teeth

(5) removing the setting material

(6) applying a self-curing composition to a portion of the inward facing surface(s) of the teeth and the area where the setting material was located

(6) allowing the self-curing compositions to dry

(7) removing the cured composition and associated teeth (the oral prosthesis) from the cast

and (8) preferably polishing the oral prosthesis.

Priority:

Inventor: MANCINO NOEMI ROSALIA [AR]


Application No.: US20100196858A1  Published: 05/Aug/2010

Title: SILANOL BASED DENTAL TREATMENT

Applicant/Assignee:

Application No.: 12/728872   Filing Date: 22/Mar/2010

Abstract:Etching compositions, curable compositions, packaged products and methods of use for the treatment of bone substrate, i.e., teeth, are described. The etch solutions generally include an aqueous acidic solution with an ethylenically unsaturated monomer and a silane. The methods of the invention provide the ability to modify a bone or bone-like surface so that the curable composition, such as an adhesive resin, can be used in combination with a restorative material.

Priority: US2006-360979 Applic. Date: 2006-02-23; US20050656187P Applic. Date: 2005-02-25

Inventor: KANCA III JOHN A [US]


Application No.: US20100197599A1  Published: 05/Aug/2010

Title: USE OF A PEPTIDE AS A THERAPEUTIC AGENT

Applicant/Assignee:

Application No.: 12/677803   Filing Date: 09/Sep/2008

Abstract:The present invention is directed to the use of the peptide compound Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Priority: EP20070017756 Applic. Date: 2007-09-11; WO2008EP07710 Applic. Date: 2008-09-09

Inventor: BEVEC DORIAN [DE]; CAVALLI FABIO [CH]; CAVALLI VERA [CH]; BACHER GERALD [DE]


Application No.: US20100197754A1  Published: 05/Aug/2010

Title: CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Applicant/Assignee:

Application No.: 12/695331   Filing Date: 28/Jan/2010

Abstract:An improved AKT inhibiting compound, crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride.

Priority: US20090148490P Applic. Date: 2009-01-30

Inventor: CHEN PINGYUN Y [US]; GAULDING JEFFREY [US]


Application No.: US20100197824A1  Published: 05/Aug/2010

Title: METHACRYLATE BASED MONOMERS CONTAINING A URETHANE LINKAGE, PROCESS FOR PRODUCTION AND USE THEREOF

Applicant/Assignee:

Application No.: 12/679490   Filing Date: 23/Sep/2008

Abstract:The invention relates to a dental composition comprising a monomer or mixture of monomers represented by the following structure (1) with 1,2R independently selected from H, alkyl (e.g. CH3C2H5), and Phenyl, 3,4R independently selected from H, alkyl (e.g. CH3), and halogen (Cl, Br, F), 5R independently selected from H, alkyl (e.g. CH3), m, n=1, 2 and x+y=2 to 10, with the proviso that if m=n=2, than x+y=2 and if m=n=1, than x+y=4 to 10. The invention also relates to a process for producing the monomer or mixture of monomers and the use thereof especially as dental composition.

Priority: WO2008US77346 Applic. Date: 2008-09-23; EP20070117211 Applic. Date: 2007-09-26

Inventor: BISSINGER PETER [DE]; DEDE KARSTEN [DE]; ECKERT ADRIAN S [DE]; KESTEL MARION [DE]; THALACKER CHRISTOPH [DE]


Application No.: US20100197825A1  Published: 05/Aug/2010

Title: MULTIFUNCTIONAL ACRYLATES USED AS CROSS-LINKERS IN DENTAL AND BIOMEDICAL SELF-ETCHING BONDING ADHESIVES

Applicant/Assignee:

Application No.: 12/362622   Filing Date: 30/Jan/2009

Abstract:This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.

Priority:

Inventor: RAGAIN JR JAMES C [US]; TIBA AMER [US]; CHARLTON DAVID G [US]


Application No.: US20100197855A1  Published: 05/Aug/2010

Title: TWO-COMPONENT CURABLE POLYMER MATERIALS

Applicant/Assignee: INTERCON HOLLAND B.V

Application No.: 12/664269   Filing Date: 13/Jun/2008

Abstract:The invention relates to a two-component curable polymer system comprising a first component including a water-curable silane-modified polymer and a second component comprising water as a curing agent wherein said second component is in the form of a paste or gel.

Priority: EP20070110184 Applic. Date: 2007-06-13; US20070943698P Applic. Date: 2007-06-13; WO2008NL50377 Applic. Date: 2008-06-13

Inventor: BLOM CORNELIS WILLEM [NL]


Application No.: US20100199604A1  Published: 12/Aug/2010

Title: DEVICE AND METHOD FOR THE PRODUCTION OF PLASTIC CONTAINERS

Applicant/Assignee:

Application No.: 12/305932   Filing Date: 08/Nov/2007

Abstract:The invention relates to a device and a method for producing containers, such as e.g. bottles, in which different types of bottles are produced. Alternative treatment methods are used depending on the type of bottle to be produced. For example, a cooling treatment is carried out when producing bottles for carbonated beverages and a sterilisation treatment is carried out when producing bottles for non-carbonated beverages.

Priority: DE200610053193 Applic. Date: 2006-11-09; WO2007EP09697 Applic. Date: 2007-11-08

Inventor: FISCHER SVEN [DE]


Application No.: US20100199992A1  Published: 12/Aug/2010

Title: CUSHION INSIDE A CUSHION PATIENT INTERFACE

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 12/767882   Filing Date: 27/Apr/2010

Abstract:A patient interface device that includes a mask shell and a cushion assembly. The cushion assembly includes a seal cushion and a support cushion. The seal cushion contacts a first area of a patient's face to form a seal therewith. The support cushion defines a second area over a face of such a patient when the patient interface device is being worn. The second area overlaps at least a portion of the first area.

Priority: US2009-623597 Applic. Date: 2009-11-23; US2007-875496 Applic. Date: 2007-10-19; US2006-401065 Applic. Date: 2006-04-10; US20050670806P Applic. Date: 2005-04-13

Inventor: HO PETER CHI FAI [US]; BUSCH LANCE RANARD [US]; SMITH DAVID W [US]; MARGARIA ELIZABETH POWELL [US]


Application No.: US20100200435A1  Published: 12/Aug/2010

Title: DISPOSABLE TOOTHBRUSH

Applicant/Assignee:

Application No.: 12/368471   Filing Date: 10/Feb/2009

Abstract:A tooth care kit, comprising a set of disposable handle attachments and a set of disposable brush attachments each arranged to interfit with a corresponding one of the set of disposable handle attachments.

Priority:

Inventor: BAUS HENRY [CO]


Application No.: US20100200533A1  Published: 12/Aug/2010

Title: VIAL WITH PUSH-BUTTON RELEASE CLOSURE

Applicant/Assignee:

Application No.: 12/703035   Filing Date: 09/Feb/2010

Abstract:A child-resistant package includes a vial and a closure configured to mount on the vial to cover a mouth opening into a product-storage chamber of the vial. A child-resistant feature cooperates with the closure and the vial to prevent unwanted removal of the closure from the vial.

Priority: US20090151416P Applic. Date: 2009-02-10

Inventor: RICE CHAD E [US]


Application No.: US20100201986A1  Published: 12/Aug/2010

Title: EQUIPMENT AND METHOD FOR MEASURING DENTAL SHADE

Applicant/Assignee:

Application No.: 10/598017   Filing Date: 07/Feb/2005

Abstract:The invention relates to a device for measuring dental shade comprising: -illumination means (24, 40, 42, 44, 48, 50), for successively illuminating at least one part of a tooth (D) with light of various spectral ranges, -at least one sensor (26) sensitive to light coming from said tooth part, in response to the illumination, to generate for each different color of illumination, at least one measurement signal, -means (30, 32) for converting the measurement signals corresponding to said tooth part, into the coordinates of a measurement point (202), in a shade space in which "reference" points (320, 410, 540) are also defined, corresponding to the preset shades of a dental shade guide, and-search means (114), for the tooth part, for a shade corresponding to the reference point closest to the measurement point, in the shade space.

Priority: EP20040356023 Applic. Date: 2004-02-20; WO2005EP01208 Applic. Date: 2005-02-07

Inventor: INGLESE JEAN-MARC [FR]; GROGUENEC ANNE [FR]; BARNEOUD JULIEN [FR]


Application No.: US20100202981A1  Published: 12/Aug/2010

Title: COMPOSITIONS HAVING IMPROVED SUBSTANTIVITY

Applicant/Assignee:

Application No.: 12/765333   Filing Date: 22/Apr/2010

Abstract:The present invention relates to oral care compositions providing improved substantivity to and for the tissues and hard surfaces of the oral cavity.

Priority: US2005-133098 Applic. Date: 2005-05-19

Inventor: PAN PAULINE [US]


Application No.: US20100202983A1  Published: 12/Aug/2010

Title: SELECTIVELY TARGETED ANTIMICROBIALS FOR THE TREATMENT OF PERIODONTAL DISEASE

Applicant/Assignee:

Application No.: 12/700396   Filing Date: 04/Feb/2010

Abstract:Compositions and methods for local delivery of selectively targeted antimicrobials are disclosed for the treatment of periodontal disease by eliminating or significantly reducing specific pathogenic bacteria from the bacterial biofilm (plaque) occupying the gingival crevice or periodontal pocket. A carrier agent is utilized to allow for retention, penetration and sustained release.

Priority: US20090150865P Applic. Date: 2009-02-09

Inventor: JERNBERG GARY R [US]


Application No.: US20100203092A1  Published: 12/Aug/2010

Title: Dental, Particularly Remineralizing Composition, Effective for Pain Sensitive Teeth, and Dental Particles, Particularly for Said Composition

Applicant/Assignee:

Application No.: 12/444205   Filing Date: 02/Oct/2007

Abstract:The invention relates to a dental, particularly a remineralizing composition, effective for pain sensitive teeth, such as toothpaste, tooth powder, mouth wash, chewing gum, dental formulations or the like, comprising spherical dental particles having a particle size between 0.1 and 2 [mu]m made of silica gel in an one-part combination, comprising at least one combination agent selected from at least a phosphate, a oxide, a further oxygen-containing compound, a hydroxide, hydrogen carbonate or carbonate of the metals of groups II and III of the periodic system, as well as zinc or tin, wherein the dental particles are present in an amount such that the SiO2 amount resulting from the silica gel is less than 1 wt. %.

Priority: DE200610046952 Applic. Date: 2006-10-04; WO2007EP60441 Applic. Date: 2007-10-02

Inventor: LEY FRITZ [DE]; CURRO FREDERICK [US]; ALBERT HEIDI [DE]


Application No.: US20100203121A1  Published: 12/Aug/2010

Title: FORMATION OF NANOMETRIC CORE-SHELL PARTICLES HAVING A METAL OXIDE SHELL

Applicant/Assignee: SOL-GEL TECHNOLOGIES, LTD

Application No.: 12/518743   Filing Date: 12/Dec/2007

Abstract:A process for preparing nanocapsules having a core-shell structure, comprising: (a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor

(b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion

and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.

Priority: US20060874268P Applic. Date: 2006-12-12; WO2007IL01541 Applic. Date: 2007-12-12

Inventor: TOLEDANO OFER [IL]; SERTCHOOK HANAN [IL]; ABU-REZIQ RAED [IL]; BAR-SIMANTOV HAIM [IL]; SHAPIRO LEORA [IL]


Application No.: US20100203166A1  Published: 12/Aug/2010

Title: METHODS OF PREVENTING RESPIRATORY INFECTIONS

Applicant/Assignee:

Application No.: 12/764302   Filing Date: 21/Apr/2010

Abstract:Methods for inhibiting the development of respiratory infections in humans are disclosed. One embodiment of the methods comprises pouring a predetermined amount of an oral rinse, capable of rendering ineffective a pathogen which has recently infected the respiratory tract, into the mouth of the human, agitating the oral rinse with air for a predetermined period in order to generate concentrated vapor of the oral rinse, stopping the agitating a plurality of times during which the head is tilted forward to allow the predetermined amount of an oral rinse to move away from the back of the mouth and throat, then exhaling before inhaling such that the concentrated vapor of the oral rinse is gently forced along with exhaled air from the throat thorough the nasopharynx and the nasal passages of the human, and then inhaling slowly to pass air over the oral rinse in the mouth such that concentrated vapor of the oral rinse is gently forced along with inhaled air through the larynx, over the vocal cords, and through the trachea to the lungs. The method is performed within about one hour after the human experiences the first minor symptom and before the onset of the first major symptom of infection of the respiratory tract.

Priority: US2003-411965 Applic. Date: 2003-04-10; US20020371882P Applic. Date: 2002-04-11

Inventor: REZAKHANY SAEED [US]


Application No.: US20100203467A1  Published: 12/Aug/2010

Title: INTERPROXIMAL TOOTH COATING APPLICATOR

Applicant/Assignee: DENTSPLY CANADA LTD

Application No.: 12/425658   Filing Date: 17/Apr/2009

Abstract:The present invention relates to a tooth coating applicator (10), typically in the form of a strip (11), and a method for applying a dental sealant to a surface of a tooth (T), and specifically to the interproximal surface (S) thereof. The applicator (10) is elongated and is adapted to be typically inserted into an interproximal space (I) defined between a pair of adjacent teeth (T, T') and to be gradually slid against a dental surface of one of the teeth. The applicator (10) comprises a series of substrates (12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 36, 40, 42) for generally successively removing debris and deposits from the interproximal dental surface (S), etching (20) the dental surface (S), washing (22) the dental surface (S), drying (24, 26) the dental surface (S), carrying (28) the sealing agent and applying the sealing agent to the dental surface (S), exerting pressure (30) on the dental surface (S) during the hardening of the sealing agent, and polishing (36, 38) the dental surface (S) and its cured sealing agent.

Priority: US2001-983829 Applic. Date: 2001-10-26; US1999-301767 Applic. Date: 1999-04-29

Inventor: KARAZIVAN NAIM [CA]


Application No.: US20100203473A1  Published: 12/Aug/2010

Title: SINUS CORRECTION

Applicant/Assignee:

Application No.: 12/487505   Filing Date: 18/Jun/2009

Abstract:A sinus correction method is disclosed. For example, one embodiment comprises making an incision in gingival tissue surrounding a sinus membrane perforation, dissecting the gingival tissue from cortical bone, dissecting sinus membrane adjacent to the gingival tissue from the cortical bone, folding the sinus membrane and adjacent gingival tissue from two sides of the sinus membrane perforation, connecting the overlapping sinus membrane and adjacent gingival tissue from two sides of the sinus membrane perforation, and applying a bone graft composition adjacent to the overlapping sinus membrane, the bone graft composition to form bone connected with cortical bone sufficient to place a dental implant.

Priority: US2009-366815 Applic. Date: 2009-02-06

Inventor: CHEN CHUN-LEON [US]


Application No.: US20100203481A1  Published: 12/Aug/2010

Title: METHOD AND KIT FOR DELIVERING ENDODONTIC REGENERATIVE TREATMENT

Applicant/Assignee: NOVA SOUTHEASTERN UNIVERSITY

Application No.: 12/670017   Filing Date: 12/Dec/2008

Abstract:The present invention provides novel methods and kits for removing unhealthy or necrotic pulp tissue from inside the root canals of a tooth, and to replace it with new vascularized tissue created by regenerative endodontic treatment. The present invention provides alternatives to current root canal therapies, as well as obturation of the root canal with dental materials.

Priority: US19960013821P Applic. Date: 1996-03-21; WO2008US13699 Applic. Date: 2008-12-12

Inventor: MURRAY PETER E [US]; GARCIA-GODOY FRANKLIN [US]


Application No.: US20100204136A1  Published: 12/Aug/2010

Title: USE OF A PEPTIDE AS A THERAPEUTIC AGENT

Applicant/Assignee:

Application No.: 12/677582   Filing Date: 09/Sep/2008

Abstract:The present invention is directed to the use of the peptide compound Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Priority: EP20070017764 Applic. Date: 2007-09-11; WO2008EP07847 Applic. Date: 2008-09-09

Inventor: BEVEC DORIAN [DE]


Application No.: US20100204161A1  Published: 12/Aug/2010

Title: Substances and Pharmaceutical Compositions for the Inhibition of Glyoxalases and Their Use Against Bacteria

Applicant/Assignee: BIOMAC PRIVATINSTITUT FUR MEDIZINISHE UND ZAHMEDIZ FORSCHUNG, ENTWICKLUNG UND DIAGNOSTIK GMBH

Application No.: 12/159633   Filing Date: 13/Apr/2006

Abstract:The present invention pertains to substances of the formula (I) wherein X is O or S

and R1-R4 are defined in the claims as inhibitors of glyoxalase I and/or II, pharmaceutical compositions comprising one or more compounds according to formula (I) and the use of one or more compounds according to formula (I) for the treatment of diseases associated with increased glycolytic metabolism. In one embodiment, the disease is a bacterial infection.

Priority: DE200510018641 Applic. Date: 2005-04-15; DE200510018642 Applic. Date: 2005-04-15; WO2006EP03466 Applic. Date: 2006-04-13

Inventor: HUSE KLAUS [DE]; BIRKENMEIER GERD [DE]; BIRKENMEIER MONIKA [DE]


Application No.: US20100204196A1  Published: 12/Aug/2010

Title: 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer

Applicant/Assignee:

Application No.: 12/671960   Filing Date: 06/Aug/2008

Abstract:Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.

Priority: US20070954649P Applic. Date: 2007-08-08; US20080030082P Applic. Date: 2008-02-20; WO2008US72267 Applic. Date: 2008-08-06

Inventor: CHAMBERLAIN STANLEY DAWES [US]; DEANDA JR FELIX [US]; GERDING ROSEANNE [US]; HASEGAWA MASAICHI [JP]; KUNTZ KEVIN [US]; LEI HUANGSHU [US]; MIYAZAKI YASUSHI [JP]; NISHIGAKI NAOHIKO [JP]; PATNAIK SAMARJIT [US]; REDMAN ANIKO [US]; SHOTWELL JOHN BRAD [US]; STEVENS KIRK [US]; WILSON JOSEPH [US]; YANG BIN [US]


Application No.: US20100204212A1  Published: 12/Aug/2010

Title: FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS

Applicant/Assignee: BRISTOL-MYERS SQUIBB COMPANY

Application No.: 12/756253   Filing Date: 08/Apr/2010

Abstract:Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N, and R1, R2, R3, X and Y are as defined herein.

Priority: US2007-689132 Applic. Date: 2007-03-21; US2006-524996 Applic. Date: 2006-09-21; US20050719519P Applic. Date: 2005-09-22

Inventor: VACCARO WAYNE [US]; TORTOLANI DAVID R [US]; HUYNH TRAM N [US]


Application No.: US20100204330A1  Published: 12/Aug/2010

Title: Diclofenac Formulations and Methods of Use

Applicant/Assignee: APR APPLIED PHARMA RESEARCH S.A

Application No.: 12/683517   Filing Date: 07/Jan/2010

Abstract:Methods and formulations are provided for treating migraine and other acute pain episodes using diclofenac, and formulations of diclofenac that provide both rapid and sustained relief from acute pain. Methods and formulations are also provided for treating symptoms that often accompany migraine and acute pain such as photophobia, phonophobia, nausea and vomiting.

Priority: US2006-455120 Applic. Date: 2006-06-16; US20050692024P Applic. Date: 2005-06-17; US20050691757P Applic. Date: 2005-06-17

Inventor: REINER GIORGIO [IT]; REINER ALBERTO [IT]; MEYER ANDREAS [DE]


Application No.: US20100204434A1  Published: 12/Aug/2010

Title: Process For The Preparation Of Particularly Reactive And Low-Viscosity Allophanates Having Actinic-Curable Groups And The Use Thereof For The Preparation Of Particularly Scratch-Resistant Coatings

Applicant/Assignee: BAYER MATERIALSCIENCE AG

Application No.: 12/704749   Filing Date: 12/Feb/2010

Abstract:The present invention relates to a process for the preparation of particularly reactive and low-viscosity reaction products of polyisocyanates which contain activated ethylenically unsaturated groups which react by polymerization under the action of actinic radiation, and the use of these reaction products in coating compositions, and particularly scratch-resistant coatings obtainable therefrom.

Priority: DE200910008569 Applic. Date: 2009-02-12

Inventor: LUDEWIG MICHAEL [DE]; FISCHER WOLFGANG [DE]; KUCZEWSKI HELMUT [DE]


Application No.: US20100206315A1  Published: 19/Aug/2010

Title: Cardiopulmonary Resuscitation Device

Applicant/Assignee:

Application No.: 12/709018   Filing Date: 19/Feb/2010

Abstract:A cardiopulmonary resuscitation device that combines ventilation of a patient's lungs with chest compressions on the patient's sternum area. The device includes a self-inflating bag having an outlet port through which the content of the bag is forced when bag is compressed

target indicia on the bag to indicate the proper position of the bag on the patient's sternum area and to indicate the proper location on the bag for applying force to the top side thereof

a face mask for placement over the patient's mouth and nose

and a tube extending from the bag to the face mask. The device may include indicia for indicating the amount of pressure applied to the self-inflating bag, and a backboard including belt/motor structure for providing repeated and rapid chest compression and forced ventilation of the patient's lungs.

Priority: US2006-327278 Applic. Date: 2006-01-06; US2004-820239 Applic. Date: 2004-04-06

Inventor: THOMPSON DARRELL K [US]; THOMPSON PHYLLIS D [US]


Application No.: US20100206764A1  Published: 19/Aug/2010

Title: Dehydrated and Semi-Hydrated Personal Care Items

Applicant/Assignee:

Application No.: 12/372084   Filing Date: 17/Feb/2009

Abstract:A personal care item is disclosed. The personal care item includes at least one partially dehydrated personal care item formulated without at least one aqueous ingredient to thereby allow travelers to bring personal care items while complying with present security restrictions regarding the transport of liquids on transportation means and when said at least one partially dehydrated personal care item is combined with at least one aqueous ingredient, the personal care item is in a usable form.

Priority:

Inventor: KETCHUM RUSS [US]


Application No.: US20100206964A1  Published: 19/Aug/2010

Title: Pump head assembly and pressure washer with such pump head assembly

Applicant/Assignee:

Application No.: 12/702328   Filing Date: 09/Feb/2010

Abstract:The patent application relates to a pump head assembly. The pump head assembly includes a pump head which at least has a water inlet and a first water outlet between which a pressurizing unit is provided, and the pump head further includes a second water outlet, a throttle orifice is provided between the water inlet and the second water outlet, the throttle orifice is provided with a water outlet end and a water inlet end, the throttle orifice is provide with a liquid suction port, and a one way valve is provided on the liquid suction port. The pump head assembly realizes cleaning liquid suction by self-pressure of tap water, which lowers energy consumption, and effectively and reasonably saves energy sources.

Priority: CN20091024800 Applic. Date: 2009-02-16

Inventor: LI JIANG [CN]; WANG BO [CN]; LING YINGTANG [CN]


Application No.: US20100208544A1  Published: 19/Aug/2010

Title: Dynamic mixer

Applicant/Assignee: SULZER MIXPAC AG

Application No.: 12/676466   Filing Date: 06/Jun/2008

Abstract:The invention relates to a dynamic mixer for viscose components in particular for the mixing of dental compositions, with a rotor (30) and a housing (2), which has front inlet openings (12, 13) for the components and at least one rear outlet opening (20) and the inner space of which includes a pre-chamber (17) and a main chamber (22), with the pre-chamber (17) opening into the main chamber (22) in a distal, tapering transition section (16). For the precise regulation of the concentration of the components to be mixed of the supplied components even with temporary concentration fluctuations of the same and in order to achieve a high degree of homogenization, it is proposed that the dynamic mixer (1) has at least one individual channel (23a-d) as a passage from the pre-chamber (17) into the main chamber (22), with the width of the individual channel (23a-d) extending over a part of the periphery of the transition section (16).

Priority: WO2008EP57049 Applic. Date: 2008-06-06

Inventor: WINTERGERSTE TORSTEN [CH]; HOLDENER HUBERT [CH]; LEUE PERCY [DE]


Application No.: US20100209388A1  Published: 19/Aug/2010

Title: Nutraceutical composition and method of use for treatment / prevention of cancer

Applicant/Assignee:

Application No.: 12/657903   Filing Date: 30/Jan/2010

Abstract:The invention describes a nutraceutical composition and method for preventing/treating cancer comprised of A) quinones (2,3-dimethoxy-5-methyl-1,4-benzoquinone, thymoquinone, tocopherolquinone) B) compounds capable of maximizing oxidative mitochondrial function preferably riboflavin, FAD, FMN, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B1, lipoic acid, biotin, vitamin B6, vitamin B12, folate, B3, C and pantothenate C) lactic acid dehydrogenase inhibitors

2',3,4'5,7-pentahydroxyflavone, epigallocatechin gallate, quercetin, citric acid, rosemary, black walnut, clove, nutmeg, licorice root, coriander, cinnamon, ginger root, myrrh gum and green tea D) alkalizing agents: aloe vera, chlorella, wheat grass, apple cider vinegar, burdock root, kudzu root, alfalfa, barley grass, spirulina, parsley leaf, calcium, magnesium, potassium or bicarbonate salts E) potent tumoricidal herbs

gromwell root, wild yam, beth root, teasel root, balm of gilead bud, frankincense, bakuchi seed, dichroa root, kochia seed, kanta kari, sweet myrrh, galbanum, garcinia fruit, mace, white sage and tumoricial plant derived constituents: gambogic acid, shikonin, diosmin or boswellic acid F) an antiproliferative herb (speranskia or goldenseal) and G) a pharmaceutically acceptable carrier.

Priority: US2007-711833 Applic. Date: 2007-02-28; US2005-233279 Applic. Date: 2005-09-20; US2004-909590 Applic. Date: 2004-08-02; US20030491841P Applic. Date: 2003-08-02; US20040540525P Applic. Date: 2004-01-29

Inventor: MAZZIO ELIZABETH ANNE [US]; SOLIMAN KARAM F [US]


Application No.: US20100209408A1  Published: 19/Aug/2010

Title: Remodeling of Tissues and Organs

Applicant/Assignee: LIFECELL CORPORATION WRIGHT MEDICAL TECHNOLOGY, INC

Application No.: 12/716828   Filing Date: 03/Mar/2010

Abstract:The invention provides methods of repairing damage to, or defects in, mammalian tissues or organs. In these methods, a particulate or non-particulate acellular matrix made from a tissue or organ other than the tissue or organ being repaired is placed in or on the organ or tissue that is being repaired.

Priority: US2002-273780 Applic. Date: 2002-10-18; US20010347913P Applic. Date: 2001-10-18; US20020398448P Applic. Date: 2002-07-25

Inventor: STEPHEN A LIVESEY [AU]; MCQUILLAN DAVID J [US]; BENIKER HERBERT DANIEL [US]; BOERBOOM LAWRENCE E [US]


Application No.: US20100209533A1  Published: 19/Aug/2010

Title: CHEMICAL COMPOSITION FOR USE AS A DISINFECTANT

Applicant/Assignee:

Application No.: 12/388537   Filing Date: 19/Feb/2009

Abstract:A chemical composition is disclosed for a disinfectant, which is particularly usefully for disinfecting toothbrushes and other oral and/or dental products. One or more chemical compositions may be applied to an object, such as the bristles of a toothbrush with a portable spray container.

Priority:

Inventor: STEPP JENNY [US]; STEPP JIM [US]; PERSICO SAVERIO [US]


Application No.: US20100209879A1  Published: 19/Aug/2010

Title: COLOR TEST COMPOSITION FOR DENTAL TREATMENT

Applicant/Assignee: SHOFU INC

Application No.: 12/640046   Filing Date: 17/Dec/2009

Abstract:A dental tone match checking material is provided that makes possible the elaboration of better esthetics than in the prior art. The present invention is a dental tone match checking material and relates to a dental tone match checking material, wherein the difference (n1-n0) between the refractive index n1 of this material and the refractive index no of the cured product from the dental cement that is checked with the dental tone match checking material is in the range from -0.040 to +0.020.

Priority: JP20080321984 Applic. Date: 2008-12-18

Inventor: FUKUCHI JUNJI [JP]; TORII KEISUKE [JP]; NEGORO NORIYUKI [JP]


Application No.: US20100210528A1  Published: 19/Aug/2010

Title: Compositions, methods and uses for inhibition and/or treatment of influenza infection

Applicant/Assignee:

Application No.: 12/586818   Filing Date: 29/Sep/2009

Abstract:Embodiments of the present invention illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing or inhibiting a the onset or development of a viral disorder.

Priority: US2005-044224 Applic. Date: 2005-01-28; US2000-518098 Applic. Date: 2000-03-03; US19990137795P Applic. Date: 1999-06-03; US19990123167P Applic. Date: 1999-03-05

Inventor: SHAPIRO LELAND [US]


Application No.: US20100210536A1  Published: 19/Aug/2010

Title: USE OF LEPTIN (22-56 ) AS A THERAPEUTIC AGENT

Applicant/Assignee:

Application No.: 12/677572   Filing Date: 09/Sep/2008

Abstract:The present invention is directed to the use of the peptide compound Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val-Ser-Ser-Lys-Gln-Lys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val-Ser-Ser-Lys-Gln-Lys-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Priority: EP20070017749 Applic. Date: 2007-09-11; WO2008EP07708 Applic. Date: 2008-09-09

Inventor: BEVEC DORIAN [DE]; CAVALLI FABIO [CH]; CAVALLI VERA [CH]; BACHER GERALD [DE]


Application No.: US20100210753A1  Published: 19/Aug/2010

Title: X-ray Opaque Barium-Free Glasses and Uses Thereof

Applicant/Assignee: SCHOTT AG

Application No.: 12/695376   Filing Date: 28/Jan/2010

Abstract:Zirconium-containing BaO- and PbO-free X-ray opaque glasses having a refractive index nd of about 1.518 to about 1.533 and a high X-ray opacity with an aluminum equivalent thickness of at least about 180% are provided. Such glasses are based on a SiO2-Al2O3-B2O3 system with additions of K2O, ZrO2, and one or both of La2O3 and Cs2O. Such glasses may be used, in particular, as dental glasses or as optical glasses.

Priority: DE200910008951 Applic. Date: 2009-02-13

Inventor: RITTER SIMONE MONIKA [DE]; HOCHREIN OLIVER [DE]; PICHLER-WILHELM SABINE [DE]


Application No.: US20100210754A1  Published: 19/Aug/2010

Title: X-ray Opaque Barium-Free Glasses and Uses Thereof

Applicant/Assignee: SCHOTT AG

Application No.: 12/695387   Filing Date: 28/Jan/2010

Abstract:Zirconium-containing BaO- and PbO-free X-ray opaque glasses having a refractive index nd of about 1.480 to about 1.517 and a high X-ray opacity with an aluminum equivalent thickness of at least about 180% are provided. Such glasses are based on a SiO2-B2O3-Cs2O-K2O-La2O3 system with additions of Al2O3, Li2O, Na2O and/or ZrO2. Such glasses may be used, in particular, as dental glasses or as optical glasses.

Priority: DE200910008954 Applic. Date: 2009-02-13

Inventor: RITTER SIMONE MONIKA [DE]; HOCHREIN OLIVER [DE]; PICHLER-WILHELM SABINE [DE]


Application No.: US20100210755A1  Published: 19/Aug/2010

Title: X-ray Opaque Barium-Free Glasses and Uses Thereof

Applicant/Assignee: SCHOTT AG

Application No.: 12/695419   Filing Date: 28/Jan/2010

Abstract:Zirconium-containing BaO- and PbO-free X-ray opaque glasses having a refractive index nd of about 1.57 to about 1.61 and a high X-ray opacity with an aluminum equivalent thickness of at least about 400% are provided. Such glasses are based on a SiO2-Al2O3 -La2O3 -ZrO2 -Cs2O system with additions of Li2O, Na2O, ZnO and/or Ta2O5. Such glasses may be used, in particular, as dental glasses or as optical glasses.

Priority: DE200910008953 Applic. Date: 2009-02-13

Inventor: RITTER SIMONE MONIKA [DE]; HOCHREIN OLIVER [DE]; PICHLER-WILHELM SABINE [DE]


Application No.: US20100211150A1  Published: 19/Aug/2010

Title: FACE AND MOUTH MUSCLE STIMULATOR

Applicant/Assignee:

Application No.: 12/733662   Filing Date: 10/Sep/2008

Abstract:The invention relates to a face and mouth muscle stimulator formed by an approximately oblong, oval body (1) to be placed in the mouth, having an open central part and side ends (2) that are wider than the upper and lower mid-zones (3) which are provided with V-shaped recesses (4) at the position of the frenulum. Optionally, the invention can include fixed or removable projections (5) positioned on the stimulator or on attachments (8). The invention can also include a sheet (6) provided with holes (7) for the connection of elements such as bottles or pacifiers or provided with a horizontal groove (11) for the incorporation of a bite splint (12) coupled at the front (2b) thereof using T-shaped flanges (13). Alternatively, the body (1') can have a V-shaped configuration formed by vertical walls (20 and 30) in order to be positioned in the inner space of the lower jaw, including perpendicular projections (40 and 50) by way of horizontal bite planes.

Priority: ES20070002446 Applic. Date: 2007-09-14; ES20080001949 Applic. Date: 2008-06-30; ES20080001972 Applic. Date: 2008-07-01; WO2008ES00582 Applic. Date: 2008-09-10

Inventor: DURAN VON ARX JOSE [ES]


Application No.: US20100212531A1  Published: 26/Aug/2010

Title: FLECHETTE CARTRIDGE

Applicant/Assignee: DINDL FIREARMS MANUFACTURING, INC

Application No.: 11/880328   Filing Date: 20/Jul/2007

Abstract:A flechette cartridge is provided, containing a plurality of flechettes, capable of firing the flechettes in a concentrated and accurate spread pattern upon firing. In particular, both low and high velocity flechette cartridges are provided, which accurately disperse flechettes in a concentrated spread pattern. The flechette cartridge minimizes the parasitic launch mass to maximize flechette payload, flechette velocity and kinetic energy, and to maximize target effects. The flechette cartridge provides a robust means for reliably stripping the flechette payload cup.

Priority:

Inventor: DINDL FRANK J [US]; JONES KENNETH R [US]


Application No.: US20100212545A1  Published: 26/Aug/2010

Title: CALCIUM-CONTAINING RESTORATION MATERIALS

Applicant/Assignee: ADA FOUNDATION

Application No.: 12/772843   Filing Date: 03/May/2010

Abstract:A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.

Priority: WO2004US07422 Applic. Date: 2004-03-11; US2004-552337 Applic. Date: 2004-03-11; US20030461338P Applic. Date: 2003-04-08; US2002-057554 Applic. Date: 2002-01-23; US20010263894P Applic. Date: 2001-01-24

Inventor: CHOW LAURENCE C [US]; TAKAGI SHOZO [US]


Application No.: US20100212671A1  Published: 26/Aug/2010

Title: Airway Devices, Tube Securing Devices, and Methods of Making and Using the Same

Applicant/Assignee:

Application No.: 12/390771   Filing Date: 23/Feb/2009

Abstract:Airway devices and tube securing devices are disclosed. Methods of making and using airway devices and tube securing devices are also disclosed.

Priority:

Inventor: MILLER PATRICK JOHN [US]; DAUGHERTY DAVID ALAN [US]; HALL MICHAEL D [US]


Application No.: US20100213157A1  Published: 26/Aug/2010

Title: FEEDING BOTTLE FOR BABIES

Applicant/Assignee:

Application No.: 12/601223   Filing Date: 19/Mar/2008

Abstract:The invention relates to a baby feeding bottle and an assembly therefor. The baby feeding bottle includes a container and a teat unit. The teat unit includes a teat, a teat support and means for piercing a membrane arranged on the mouth of the container. The bottle further includes a teat unit and container separation resistance arrangement. The teat unit is configured so that the means for piercing the membrane pierce the membrane when the teat unit, or part thereof, is moved, in use, towards the membrane so that the baby feed is accessible through the teat.

Priority: ZA20070004334 Applic. Date: 2007-05-27; WO2008ZA00022 Applic. Date: 2008-03-19

Inventor: HAMILTON-HALL JOHN MICHAEL [ZA]


Application No.: US20100215591A1  Published: 26/Aug/2010

Title: ANTIMICROBIAL PEPTIDE, COMPOSITIONS, AND METHODS OF USE

Applicant/Assignee: REVANCE THERAPEUTICS, INC

Application No.: 12/669705   Filing Date: 28/Jul/2008

Abstract:The present invention provides antimicrobial peptides that exhibit a broad range of antimicrobial activity to gram positive and gram negative bacteria, as well as fungi, mold, and virus. The antimicrobial peptide of the invention is a cationic peptide, and may contain an HIV-TAT or reverse HIV-TAT sequence, or derivative thereof. The present invention further provides antimicrobial compositions containing the cationic peptide. Such compositions are especially useful for topical application to the skin, hair, nail, vagina, urethra, ear, oral cavity, nasal passage, respiratory system, opthalmic region, and various mucosal regions. The compositions of the present invention improve the condition and/or appearance of the treated region, and are suited for long-term and/or routine use to, for example, prevent or prevent the recurrence of microbial infection. The present invention further provides kits for use in improving the condition or appearance of skin, nail, or treated area. These kits may facilitate ease of use, long-term storage, and/or efficacy of the compositions.

Priority: US20070952059P Applic. Date: 2007-07-26; WO2008US71350 Applic. Date: 2008-07-28

Inventor: STONE HONGRAN FAN [US]; WAUGH JACOB M [US]


Application No.: US20100215726A1  Published: 26/Aug/2010

Title: Compositions for Diminishing the Appearance of Wrinkles

Applicant/Assignee:

Application No.: 12/392949   Filing Date: 25/Feb/2009

Abstract:Topical skin care compositions are provided for the improvement of the appearance of the skin, namely of the skin comprising the face, surrounding the eyes, mouth, and hands, as well as the skin of the body. The skin care compositions include synergistic combinations of active peptide ingredients that are specially formulated to enhance the natural appearance of the face, hands, and/or body. Specifically, the synergistic skin care compositions may be applied to one or more of the skin surrounding the eyes, mouth, nose, forehead, ears, neck, hands, feed, and overall body to give the skin thereof a cleaner, smoother and more wrinkle free appearance.

Priority:

Inventor: ROTH PETER THOMAS [US]


Application No.: US20100215728A1  Published: 26/Aug/2010

Title: Skincare Methods

Applicant/Assignee: ASAN LABORATORIES COMPANY (CAYMAN), LIMITED

Application No.: 12/700843   Filing Date: 05/Feb/2010

Abstract:Disclosed are compositions and methods for skincare, e.g., reducing skin wrinkles and for treating skin disorders.

Priority: US2007-848272 Applic. Date: 2007-08-31; US2006-499936 Applic. Date: 2006-08-07; US2004-798119 Applic. Date: 2004-03-11; US2002-205738 Applic. Date: 2002-07-25; US2004-843025 Applic. Date: 2004-05-10; US2005-079370 Applic. Date: 2005-03-14; US2002-132999 Applic. Date: 2002-04-26

Inventor: CHUNG YIH-LIN [TW]; PUI NAM-MEW [TW]; CHANG WEI-WEI [US]


Application No.: US20100215774A1  Published: 26/Aug/2010

Title: FILM COMPRISING NITROGLYCERIN

Applicant/Assignee:

Application No.: 12/526583   Filing Date: 08/Feb/2008

Abstract:The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin and/or other active drugs through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.

Priority: US20070900328P Applic. Date: 2007-02-09; WO2008US53466 Applic. Date: 2008-02-08

Inventor: MAIBACH TODD [US]


Application No.: US20100215804A1  Published: 26/Aug/2010

Title: FOOD PRODUCT SUITABLE FOR PERSON WHO HAS DIFFICULTY IN CHEWING OR SWALLOWING

Applicant/Assignee:

Application No.: 12/681233   Filing Date: 30/Sep/2008

Abstract:A food product that is suitable for an elderly person or a person who has difficulty in chewing or swallowing is obtained by impregnating a material with an enzyme, said food product having a smooth texture and sufficient softness to be crushed by the gums or tongue in the mouth, while maintaining the natural shape and color of the material. The food product has a compressive strength of 5104 N/m2 or lower when measured at a compression rate of 10 mm/sec by using a plunger with a diameter of 3 mm and setting the clearance at 30% of the thickness of the specimen.

Priority: JP20070258797 Applic. Date: 2007-10-02; JP20070327160 Applic. Date: 2007-12-19; JP20070340457 Applic. Date: 2007-12-28; WO2008JP02740 Applic. Date: 2008-09-30

Inventor: GOTO REIKA [JP]; TAKEI RYO [JP]; KITAMURA KEN [JP]; SUGIMURA KEN-ICHIROU [JP]; KURIBAYASHI MINORU [JP]


Application No.: US20100216763A1  Published: 26/Aug/2010

Title: Heteroaryl Amide Derivatives

Applicant/Assignee: H. LUNDBECK A/S

Application No.: 12/516480   Filing Date: 27/Nov/2007

Abstract:Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Priority: US20060867248P Applic. Date: 2006-11-27; WO2007US24396 Applic. Date: 2007-11-27

Inventor: HUTCHISON ALAN J [US]; LI HONGBIN [US]; MAO JIANMIN [US]; WUSTROW DAVID J [US]; YUAN JUN [US]; ZHAO HE [US]


Application No.: US20100216779A1  Published: 26/Aug/2010

Title: Imidazopyridine Kinase Inhibitors

Applicant/Assignee: GLAXOSMITHKLINE LLC

Application No.: 12/602289   Filing Date: 28/May/2008

Abstract:The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Priority: US20070941423P Applic. Date: 2007-06-01; US20080024294P Applic. Date: 2008-01-29; US20080035135P Applic. Date: 2008-03-10; WO2008US64977 Applic. Date: 2008-05-28

Inventor: BAUM ERIC W [US]; EMMITTE KYLE ALLEN [US]; KUNTZ KEVIN WAYNE [US]; MOOK JR ROBERT ANTHONY [US]; NAILOR KRISTEN ELIZABETH [US]; SALOVICH JAMES MICHAEL [US]; SHOTWELL JOHN BRAD [US]; SMITH STEPHON CORNELL [US]; STEVENS KIRK LAWRENCE [US]; UEHLING DAVID EDWARD [US]; WATERSON ALEX GREGORY [US]; CHEUNG MUI [US]; MOORTHY GANESH S [US]; WILSON BRIAN JOHN [US]


Application No.: US20100216781A1  Published: 26/Aug/2010

Title: mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY

Applicant/Assignee:

Application No.: 12/605791   Filing Date: 26/Oct/2009

Abstract:Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Priority: US20080108627P Applic. Date: 2008-10-27

Inventor: PERRIN-NINKOVIC SOPHIE [US]; HARRIS ROY L [US]; SAPIENZA JOHN [US]; SHEVLIN GRAZIELLA [US]; PAPA PATRICK [US]; LEE BRANDEN [US]; PACKARD GARRICK [US]; TEHRANI LIDA [US]; ZHAO JINGJING [US]; RIGGS JENNIFER [US]; PARNES JASON [US]; MORTENSEN DEBORAH [US]; XU WEIMING [US]; MADAKAMUTIL LOUI [US]; FULTZ KIMBERLY [US]; NARLA RAMA K [US]; SANKAR SABITA [US]; ELSNER JAN [US]


Application No.: US20100216865A1  Published: 26/Aug/2010

Title: MicroRNA COMPOSITIONS IN THE TREATMENT OF VEGF-MEDIATED DISORDERS

Applicant/Assignee:

Application No.: 12/677625   Filing Date: 29/Sep/2008

Abstract:The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VEGF polypeptide.

Priority: JP20070237034 Applic. Date: 2007-09-12; WO2008US11242 Applic. Date: 2008-09-29

Inventor: ELIAS JACK A [JP]


Application No.: US20100216916A1  Published: 26/Aug/2010

Title: METHYLENE BLUE

Applicant/Assignee: STRAUMANN HOLDING AG

Application No.: 12/773387   Filing Date: 04/May/2010

Abstract:Composition comprising a polymerizable compound with at least one conjugated unsaturated group and methylene blue to prevent premature polymerization of the polymerizable compound. The methylene blue is present in a concentration of 10 to 5000 ppm.

Priority: EP20040014072 Applic. Date: 2004-06-16; EP20050020181 Applic. Date: 2005-09-16; US2007-872234 Applic. Date: 2007-10-15; US2006-521971 Applic. Date: 2006-09-15; US2006-629567 Applic. Date: 2006-12-14; WO2005EP04977 Applic. Date: 2005-05-09

Inventor: MOLENBERG AALDERT [CH]


Application No.: US20100221196A1  Published: 02/Sep/2010

Title: METHOD FOR CLEANING DENTAL PLAQUE FROM TEETH USING AN ADHERENT PEELABLE GEL

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 12/672710   Filing Date: 08/May/2008

Abstract:The method for cleaning dental plaque biofilm from the teeth includes the steps of applying a liquid gellable composition to the teeth, the composition including a positively charged polymer such as chitosan, the liquid composition having a viscosity which results in coverage of substantially all of the exposed areas of the teeth. The liquid composition is then gelled by the addition of a second composition, such as a negatively charged compound. The resulting gelled composition has an adherence to the plaque biofilm which is greater than the adherence between the biofilm and the teeth. The gel layer with the biofilm is peeled off of the teeth, removing the dental plaque.

Priority: US20070916353P Applic. Date: 2007-05-07; WO2008IB51835 Applic. Date: 2008-05-08

Inventor: GOTTENBOS BART [NL]; JANSSEN JOZEF JOHANNES MARIA [NL]


Application No.: US20100221308A1  Published: 02/Sep/2010

Title: ANTIMICROBIAL COMPOSITIONS AND USES THEREOF

Applicant/Assignee: KANE BIOTECH INC

Application No.: 12/778208   Filing Date: 12/May/2010

Abstract:The present invention includes compositions for preventing growth and proliferation of biofilm embedded microorganisms comprising: (a) a cationic polypeptide and (b) a bis-gaunide or a salt thereof. The invention further provides methods for preparing objects with such compositions, and objects and consumables (such as household cleaners) comprising such compositions.

Priority: US2007-750826 Applic. Date: 2007-05-18; US2006-331423 Applic. Date: 2006-01-11; US20050695546P Applic. Date: 2005-07-01; US20050742972P Applic. Date: 2005-12-06

Inventor: MADHYASTHA SRINIVASA [CA]; GAWANDE PURUSHOTTAM [CA]; LOVETRI KAREN [CA]


Application No.: US20100221352A1  Published: 02/Sep/2010

Title: PHARMACEUTICAL COMPOSITION FOR THE ONCE-A-DAY ORAL ADMINISTRATION OF TROSPIUM CHLORIDE

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778593   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100221353A1  Published: 02/Sep/2010

Title: Pharmaceutical Composition For Once-A-Day Administration of Trospium Chloride

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778604   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100221354A1  Published: 02/Sep/2010

Title: PHARMACEUTICAL COMPOSITION FOR ONCE-A-DAY ORAL ADMINISTRATION OF TROSPIUM CHLORIDE

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778609   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100221355A1  Published: 02/Sep/2010

Title: PHARMACEUTICAL COMPOSITION FOR ONCE-A-DAY ORAL ADMINISTRATION OF TROSPIUM CHLORIDE

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778664   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100221356A1  Published: 02/Sep/2010

Title: PHARMACEUTICAL COMPOSITION FOR ONCE A DAY ADMINISTRATION OF TROSPIUM CHLORIDE

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778791   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100221362A1  Published: 02/Sep/2010

Title: STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING SYNTHETIC PHOSPHORYLATED PEPTIDES

Applicant/Assignee: AMORPHICAL LTD

Application No.: 12/765009   Filing Date: 22/Apr/2010

Abstract:Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

Priority: IL20070186850 Applic. Date: 2007-10-22; IL20080193461 Applic. Date: 2008-08-14; WO2008IL01362 Applic. Date: 2008-10-22

Inventor: BENTOV SHMUEL [IL]; SAGI AMIR [IL]; BERMAN AMIR [IL]; SHECHTER ASSAF [IL]


Application No.: US20100221372A1  Published: 02/Sep/2010

Title: WOLFBERRIES AND SKIN INFLAMMATION

Applicant/Assignee:

Application No.: 12/677488   Filing Date: 12/Sep/2008

Abstract:The present invention relates in general to the field of inflammation. In particular the present invention relates to the use of natural compounds for the preparation of a product to treat or prevent inflammation. For example an extract of wolfberry was shown to have anti-inflammatory properties. One embodiment of the present invention relates to the use of a primary composition comprising wolfberries or a part thereof for the preparation of a product to treat or prevent inflammation.

Priority: EP20070116190 Applic. Date: 2007-09-12; WO2008EP62132 Applic. Date: 2008-09-12

Inventor: VIDAL KARINE [FR]; BLUM-SPERISEN STEPHANIE [CH]; PHILIPPE DAVID [FR]; BALLEVRE OLIVIER [CN]; BUCHELI PETER [CH]; WANG JUNKUAN [CH]


Application No.: US20100221540A1  Published: 02/Sep/2010

Title: Process for Producing a Porous Glass and Glass Powder and Glass Material for Carrying Out the Process

Applicant/Assignee: VITRABIO GMBH

Application No.: 12/224067   Filing Date: 24/Feb/2006

Abstract:

Priority: WO2006EP01739 Applic. Date: 2006-02-24

Inventor: HERMANN MONIKA [DE]


Application No.: US20100221678A1  Published: 02/Sep/2010

Title: Method for Indicating Shelf-Life After Mixing Pre-Dosed, Pre-Packaged Two-Part Dental Compositions

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/535500   Filing Date: 04/Aug/2009

Abstract:A pre-dosed, pre-packaged mixing system and associated method for mixing, storing, and dispensing a two-part dental composition that becomes less stable upon mixing. The mixing system includes a pre-dosed, pre-packaged quantity of a first component contained within a first chamber, and a pre-dosed, pre-packaged quantity of a second component contained within a second chamber. The chambers are separated by separation means so as to separate the two-components prior to mixing. Once mixed, the practitioner is able to record a mixing and/or expiration date on at least a portion of the mixing system so as to indicate a shelf-life of the less stable mixed dental composition.

Priority: US2006-537807 Applic. Date: 2006-10-02; US2005-258502 Applic. Date: 2005-10-25; US2006-414964 Applic. Date: 2006-05-01

Inventor: FISCHER DAN E [US]


Application No.: US20100221683A1  Published: 02/Sep/2010

Title: COLOURING SOLUTION FOR DENTAL CERAMIC ARTICLES AND RELATED METHODS

Applicant/Assignee:

Application No.: 12/669846   Filing Date: 10/Jul/2008

Abstract:The invention relates to a colouring solution for colouring a dental ceramic article, the solution comprising: a solvent and a colouring agent, comprising rare earth element metals or ions being present in the solution in an amount of at least about 0.05 mol/l solvent and transition metals or ions being present in the solution in an amount of about 0.00001 to about 0.05 mol/l solvent. The invention also relates to a process for colouring dental ceramic articles, dental ceramic articles treated either with the colouring solution or obtainable by a process comprising the step of firing the dental ceramic articles.

Priority: EP20070112920 Applic. Date: 2007-07-23; WO2008US69595 Applic. Date: 2008-07-10

Inventor: FRANKE RUEDIGER [DE]; SCHECHNER GALLUS [DE]; HAUPTMANN HOLGER [DE]; SCHNAGL ROBERT [DE]


Application No.: US20100222318A1  Published: 02/Sep/2010

Title: COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/642447   Filing Date: 18/Dec/2009

Abstract:The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention

methods of treating of various diseases, disorders, and conditions using the compounds of this invention

processes for preparing the compounds of this invention

intermediates for the preparation of the compounds of this invention

and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena

the study of intracellular signal transduction pathways mediated by such kinases

and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Priority: US20080139420P Applic. Date: 2008-12-19; US20080139424P Applic. Date: 2008-12-19; US20080139426P Applic. Date: 2008-12-19; US20080139429P Applic. Date: 2008-12-19; US20090181794P Applic. Date: 2009-05-28; US20090219100P Applic. Date: 2009-06-22

Inventor: CHARRIER JEAN DAMIEN [GB]; DURRANT STEVEN [GB]; KAY DAVID [GB]; KNEGTEL RONALD [GB]; MACCORMICK SOMHAIRLE [GB]; MORTIMORE MICHAEL [GB]; O'DONNELL MICHAEL [GB]; PINDER JOANNE [GB]; RUTHERFORD ALISTAIR [GB]; VIRANI ANISA NIZARALI [GB]; YOUNG STEPHEN [GB]; REAPER PHILIP MICHAEL [GB]


Application No.: US20100222352A1  Published: 02/Sep/2010

Title: Compounds and Methods for the Treatment of Viruses and Cancer

Applicant/Assignee: YALE UNIVERSITY

Application No.: 11/991583   Filing Date: 25/Sep/2006

Abstract:The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl

R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group

R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group

R2, R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H)

R is H or an optionally substituted C1-C6 alkyl group

RHET is an optionally substituted heterocyclic group

and pharmaceutically acceptable salts, solvates or polymorphs thereof.

Priority: US20050720307P Applic. Date: 2005-09-23; US20050730934P Applic. Date: 2005-10-27; US20060781486P Applic. Date: 2006-03-09; US20060836723P Applic. Date: 2006-08-10; US20060842901P Applic. Date: 2006-09-07; WO2006US37173 Applic. Date: 2006-09-25

Inventor: JORGENSEN WILLIAM L [US]; RUIZ-CARO JULIANA [AT]; HAMILTON ANDREW D [US]


Application No.: US20100222375A1  Published: 02/Sep/2010

Title: Pharmaceutical Composition Comprising Trospium Chloride for Once-A-Day Administration

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 12/778568   Filing Date: 12/May/2010

Abstract:A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.

Priority: US2007-889964 Applic. Date: 2007-08-17; US2004-980818 Applic. Date: 2004-11-04; US20030517198P Applic. Date: 2003-11-04; US20030523968P Applic. Date: 2003-11-21

Inventor: KIDANE ARGAW [US]; FLANNER HENRY H [US]; BHATT PADMANABH [US]; RAOUFINIA ARASH [US]


Application No.: US20100222418A1  Published: 02/Sep/2010

Title: Combination Products For Treating Cancer

Applicant/Assignee: CAYLA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Application No.: 12/681943   Filing Date: 10/Oct/2008

Abstract:The present invention concerns products containing (i) at least one nucleic acid sequence coding for the human somatostatin 2 receptor protein (sst2) having the sequence SEQ ID NO: 1, ortholog or derivative thereof, (ii) at least one nucleic acid sequence coding for the human deoxycytidine kinase protein (dck) having the sequence SEQ ID NO:2, ortholog or derivative thereof, (iii) at least one nucleic acid sequence coding for the human uridine monophosphate kinase protein (umk) having the sequence SEQ ID NO: 3 ortholog or derivative thereof, and (iv) gemcitabine, as a combined preparation for simultaneous, separate, or sequential use for treating cancer in a subject.

Priority: EP20070301447 Applic. Date: 2007-10-10; WO2008EP63657 Applic. Date: 2008-10-10

Inventor: BUSCAIL LOUIS [FR]; TIRABY GERARD [FR]; VERNEJOUL FABIENNE [FR]; SUSINI CHRISTIANE [FR]; DROCOURT DANIEL [FR]


Application No.: US20100223742A1  Published: 09/Sep/2010

Title: AIR INJECTION TYPE PORTABLE DENTAL FLOSSES

Applicant/Assignee:

Application No.: 12/681619   Filing Date: 09/Oct/2008

Abstract:An air injection portable inter-dental toothbrush can be devised consisting of: driving section (10), including air injection pan (14), filter (15) for removing foreign aerial substance from outside, pan motor (16) for bringing in air and supplying it to air injection pan (14), battery (18) as a power for driving the pan and a battery still attached bedding (19)

cleaning section (20), including cleansing fluid inlets and hose (24) which is composed of a container (21) for keeping cleansing fluid, where the cleansing fluid container (21) is connected to the hose while the other end of the latter being attached to the center of the gravity so that the fluid inlets and hose can infuse cleansing fluid no matter how the container's position changes, a valve (26) which can control cleansing fluid flow, a stopper (28) by which cleansing fluid being refilled or replaced

injecting section (30), including injecting nozzle 1 (31) where air brought in by driving section (10) and cleansing fluid supplied by cleaning section (20) blending and being injected

next to which inter-dental toothbrush section (40), including an outlet (43) for discharging air and cleansing fluid, holes (44) in plural numbers for injecting air and cleansing fluid perpendicularly and aslant, injection nozzle 2 (46a, 46b) with toothbrush bristle stuck for injecting.

Priority: KR20070101697 Applic. Date: 2007-10-09; WO2008KR05944 Applic. Date: 2008-10-09; KR20070029894 Applic. Date: 2007-03-27

Inventor: KANG SO DAE [KR]


Application No.: US20100223743A1  Published: 09/Sep/2010

Title: Cleaning Tool Assembly with a Disposable Cleaning Implement

Applicant/Assignee:

Application No.: 12/554242   Filing Date: 04/Sep/2009

Abstract:A cleaning assembly including a disposable cleaning implement having a cleaning element mounted to a fitment having an elongated post. The cleaning assembly includes an elongated maneuvering wand having a handle portion and a distal implement attachment end thereof. A gripping mechanism is coupled to the wand attachment end, and is configured to releasably grip the fitment post to mount the cleaning implement. The gripping mechanism and the maneuvering wand cooperate to substantially limited pivotal movement of a longitudinal axis of the fitment post, relative a longitudinal axis of the gripping mechanism to not more than about 0 degrees to about 25 degrees when the fitment post is subjected to forces radial to the longitudinal axis of the fitment post. In another aspect, the frictional drag between the sliding components is significantly reduced, enabling a tool assembly with a high axial holding force for the cleaning implement, but with a significantly lower, consumer friendly release force for the implement during release operation of the tool assembly.

Priority: US2007-738133 Applic. Date: 2007-04-20; US2003-678033 Applic. Date: 2003-09-30

Inventor: MINKLER DOUGLAS J [US]; BELL RUSSELL E [US]


Application No.: US20100224199A1  Published: 09/Sep/2010

Title: Respirator

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/638769   Filing Date: 14/Dec/2006

Abstract:A respirator adapted to facilitate ease of donning and comfort during use comprising one or more of an adjustable or elastic strap that facilitates ease of donning and comfort during wear

and/or fasteners that are easy to use and that facilitate ease of donning and comfort during wear

and/or respirator shapes that facilitate the wearing of eyeglasses with said respirator

and/or bellows-type, pneumatic, or other such components, associated with said respirator, that are adapted to promote adjustability of the fit of the respirator.

Priority: US20060796994P Applic. Date: 2006-05-01

Inventor: SMITH MEGAN C H [US]; REDDY KIRAN K [US]; VELAZQUEZ HERB F [US]; WELCHEL DEBRA N [US]; MCCOY THERESA M [US]; MITCHELL JOSEPH [US]; JACKSON MATRICE B [US]; LARKIN DAMON R [US]; SHEFFIELD LIZZETTE L [US]; REYES RUTHLYN [US]; KROLL RUSSELL J [US]; PALERMO PHILIP D [US]; HISATA SUZUKO [US]


Application No.: US20100224222A1  Published: 09/Sep/2010

Title: CLEANING OR CARE DEVICE FOR CLEANING OR CARE OF A MEDICAL INSTRUMENT, IN PARTICULAR A DENTAL INSTRUMENT

Applicant/Assignee: W&H DENTALWERK BURMOOS GMBH

Application No.: 12/717046   Filing Date: 03/Mar/2010

Abstract:A cleaning or care device for cleaning or care of at least one medical instrument, in particular a dental instrument having a cleaning chamber to receive the at least one instrument to be cleaned and having a media feed, through which a cleaning or care agent can be delivered into the cleaning chamber, wherein the cleaning chamber is bordered by a flexible outer shell, so that the volume of the cleaning chamber is variable. The duration of cleaning or care of the instrument is thus shortened, and the quantity of resources required for this, such as cleaning or care agent or energy, is reduced.

Priority: EP20090002967 Applic. Date: 2009-03-03

Inventor: VEDOVELLI RENZO [IT]


Application No.: US20100226819A1  Published: 09/Sep/2010

Title: Descenting systems and methods

Applicant/Assignee:

Application No.: 12/660347   Filing Date: 24/Feb/2010

Abstract:The present invention, in certain aspects, discloses systems and methods for treating a human being and/or items with descenting material, the systems, in certain aspects, including a generator for producing descenting material, and, in certain aspects at least one direction apparatus in communication with the generator for receiving produced descenting material from the generator and for directing said descenting material in a desired direction.

Priority: US2007-714083 Applic. Date: 2007-03-05; US2004-018620 Applic. Date: 2004-12-21

Inventor: ELROD SCOTT A [US]


Application No.: US20100226864A1  Published: 09/Sep/2010

Title: ALKYL-SUBSTITUTED TETRAHYDROPYRANS AS FLAVORING SUBSTANCES

Applicant/Assignee: SYMRISE GMBH & CO. KG

Application No.: 12/696200   Filing Date: 29/Jan/2010

Abstract:The present invention relates to alkyl-substituted tetrahydropyrans, mixtures containing these alkyl-substituted tetrahydropyrans, their respective use and corresponding flavored products.

Priority: US20090158162P Applic. Date: 2009-03-06

Inventor: OERTLING HEIKO [DE]; BROCKE CONSTANZE [DE]; LOGES HUBERT [DE]; MACHINEK ARNOLD [DE]


Application No.: US20100226865A1  Published: 09/Sep/2010

Title: TOOTHPASTE COMPOSITION

Applicant/Assignee:

Application No.: 12/593923   Filing Date: 28/Feb/2008

Abstract:A toothpaste composition comprising a surfactant, an abrasive, a humectant, triglyceride oil, a carboxylated polysaccharide, and a sulphated or sulphonated polysaccharide and the use of a sulphated or sulphonated polysaccharide, in particular a carrageenan, to improve the in-use foam quality of a toothpaste.

Priority: EP20070105493 Applic. Date: 2007-04-02; WO2008EP52445 Applic. Date: 2008-02-28

Inventor: FARAVELLI ILARIA [IT]; GREGORY DONALD PETER [GB]; INGEGNERI IRENE [IT]


Application No.: US20100226943A1  Published: 09/Sep/2010

Title: SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL

Applicant/Assignee: UNIVERSITY OF FLORIDA

Application No.: 12/550870   Filing Date: 31/Aug/2009

Abstract:Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings

the groupings of features include repeat units

the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers

each feature having a surface that is substantially parallel to a surface on a neighboring feature

each feature being separated from its neighboring feature

the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

Priority: US2006-567103 Applic. Date: 2006-12-05; US2005-202532 Applic. Date: 2005-08-12; US2004-780424 Applic. Date: 2004-02-17

Inventor: BRENNAN ANTHONY B [US]; LONG CHRISTOPHER JAMES [US]; BAGAN JOSEPH W [US]; SCHUMACHER JAMES FREDERICK [US]; SPIECKER MARK M [US]


Application No.: US20100226998A1  Published: 09/Sep/2010

Title: ANTI-VIRAL AND ANTI-MICROBIAL DENTAL OPERATIVE MATERIAL AND METHODS

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/398227   Filing Date: 05/Mar/2009

Abstract:An anti-microbial and/or anti-viral composition for use in disinfecting an oral tissue during a dental procedure includes at least one dental operative material that is allowed to contact the oral tissue for a period of time between about 2 seconds and about 1 month and an effective amount of an anti-viral and/or anti-bacterial agent included in or mixed with the dental operative material so as to impart an anti-bacterial and/or anti-viral effect at or near a site of administration in oral tissue. The anti-viral and/or anti-bacterial agent at least partially at least partially contributes to a two-log (or three-log, four-log, or five-log) reduction in viral and/or bacterial activity at or near a site of administration. The compositions protect a dental practitioner and/or other patient from being infected by a communicable disease carried by a treated patient.

Priority:

Inventor: FISCHER DAN E [US]


Application No.: US20100227005A1  Published: 09/Sep/2010

Title: METHODS TO TREAT AND/OR PREVENT MUCOSITIS

Applicant/Assignee: SCHERING CORPORATION

Application No.: 12/524683   Filing Date: 08/Feb/2008

Abstract:The present invention relates to methods useful for treating and/or preventing mucositis using an active vitamin D compound.

Priority: US20070889097P Applic. Date: 2007-02-09; WO2008US01716 Applic. Date: 2008-02-08

Inventor: ZONG CHEN [US]


Application No.: US20100227296A1  Published: 09/Sep/2010

Title: METHOD OF ASSESSING ORAL HEALTH RISK

Applicant/Assignee: QUANTUM DENTAL TECHNOLOGIES

Application No.: 12/718746   Filing Date: 05/Mar/2010

Abstract:A method of oral health risk assessment is provided in which diagnostic data from an oral health detection device and patient risk factor data is processed to provide a integrated risk measure relating to a patient's dental health. The patient risk factor data preferably includes risk factor data such as pathological risk factors, protective risk factors, historical factors, self care factors, behavioral factors, and extrinsic factors. The integrated risk assessment and patient data is preferably provided to a remote server for access by various authorized stakeholders.

Priority: US20090202499P Applic. Date: 2009-03-05

Inventor: MANDELIS ANDREAS [CA]; ABRAMS STEPHEN [CA]


Application No.: US20100227399A1  Published: 09/Sep/2010

Title: SOFT GEL SYSTEMS IN MODULATING STEM CELL DEVELOPMENT

Applicant/Assignee: MAKOTO FUNAKI

Application No.: 12/452268   Filing Date: 30/Jun/2008

Abstract:This invention provides gels and matrices having a rigidity in the range of 150-750 Pa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same.

Priority: US20070929488P Applic. Date: 2007-06-29; WO2008US08119 Applic. Date: 2008-06-30

Inventor: FUNAKI MAKOTO [US]; JANMEY PAUL A [US]; WINER JESSAMINE [US]


Application No.: US20100227883A1  Published: 09/Sep/2010

Title: NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee:

Application No.: 12/160403   Filing Date: 13/Feb/2007

Abstract:This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20060000233 Applic. Date: 2006-02-17; US20060774669P Applic. Date: 2006-02-21; WO2007EP51401 Applic. Date: 2007-02-13

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100227899A1  Published: 09/Sep/2010

Title: Process for the treatment of bacterial infections using 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide

Applicant/Assignee:

Application No.: 12/381120   Filing Date: 09/Mar/2009

Abstract:The subject invention demonstrates a novel antibacterial activity for 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, commonly referred to as ebselen se-oxide, and is directed to the treatment of bacterial infections by administration of an effective amount of said compound. Bacterial infections include those infections which are either systemic or superficial in nature. The treatment is intended for a variety of animals, such as premature neonates to adult humans. Administration of ebselen se-oxide to treat superficial bacterial infections may be performed by a topical application, such as via an ointment, a spray, a cream, a mouth wash, an eye drop solution, an ear drop solution, a soap, a gel, or a lotion. In addition, an antibacterial capsule can be administered orally or intravaginally. Administration of ebselen se-oxide to treat systemic bacterial infections may be performed by an intravenous route, a rectal route, an intranasal route, an oral route, an intramuscular route, or by inhalation. Administration of said compound may also be achieved via aerosol, which can be generated by a nebulizer. Ebselen se-oxide may be administered alone, or with a carrier such as dimethylsulfoxide (DMSO), an alcohol, or other suitable carrier. The effective daily amount of ebselen se-oxide is from about 1 [mu]g/kg to 10 mg/kg of body weight.

Priority:

Inventor: BILLACK BLASE CHRISTOPHER [US]; BILLACK ANETA MARTA [US]


Application No.: US20100227946A1  Published: 09/Sep/2010

Title: DENTAL COMPOSITION CONTAINING GLASS BEADS, PROCESS FOR PRODUCTION AND USE THEREOF

Applicant/Assignee:

Application No.: 12/681269   Filing Date: 01/Oct/2008

Abstract:The invention relates to a dental impression composition comprising a hardenable matrix and glass beads having a particle size (d50/[mu]m) equal or below about 60 [mu]m. The invention also relates to a method of producing this composition and its use.

Priority: EP20070117871 Applic. Date: 2007-10-04; WO2008US78376 Applic. Date: 2008-10-01

Inventor: FETZ JOHANN [DE]


Application No.: US20100229316A1  Published: 16/Sep/2010

Title: ORAL CARE IMPLEMENT

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/787564   Filing Date: 26/May/2010

Abstract:An oral care implement with a handle includes a head with a tissue cleanser. The tissue cleanser may be a pad composed of an elastomeric material. The pad is disposed on the head on a surface opposite the tooth cleaning elements. The tissue cleanser may include a plurality of nubs extending for cleaning between the papillae of the tongue. The tissue cleanser may include a plurality of conically shaped nubs. A tissue cleanser can be used to reduce oral malodor problems and remove oral epithelial cells.

Priority: US2004-019685 Applic. Date: 2004-12-23; US2004-869922 Applic. Date: 2004-06-18; US2003-601106 Applic. Date: 2003-06-20; WO2003US30633 Applic. Date: 2003-09-26; WO2003US29497 Applic. Date: 2003-09-17; US20030189729F Applic. Date: 2003-09-10; US2004-989267 Applic. Date: 2004-11-17; US20040209242F Applic. Date: 2004-07-14; US2002-109637 Applic. Date: 2002-04-01; US20010148074F Applic. Date: 2001-09-14; US2001-879606 Applic. Date: 2001-06-12; US20020414117P Applic. Date: 2002-09-27; US20020418776P Applic. Date: 2002-10-16; US20020419425P Applic. Date: 2002-10-18; US20020412290P Applic. Date: 2002-09-20

Inventor: HOHLBEIN DOUGLAS J [US]; MINTEL THOMAS E [US]; BAERTSCHI ARMIN [CH]


Application No.: US20100230508A1  Published: 16/Sep/2010

Title: God device genres cadres

Applicant/Assignee:

Application No.: 12/453444   Filing Date: 12/May/2009

Abstract:Globose-conduit (GC) conforming embodiments Universe of quintessential, core, natural disposition mass energy highest conserving (QCNDMEHC) forces completely matched complete complements compact composite Sets. 'Fluids functions' conforming least mass compositions at highest elevations least GC height least length continuous compact composite, fluid free-surfaces composite least rotations, fluids quanta forms least height perimeters most conserve mass energy. Buried GC QCNDMEHC thermal aqueducts transfer their mass-energy heat portion into subsoil, combat 'global warming', the Earth's crust surface cooling, sea levels rising and submicroscopic, subatomic to cosmos mass systems heat energy forced electro-thermodynamics electromagnetics perimeters buoyancy/density, evaporation and suction. Universal stratifications, gradations (SG) processes 'global warming', energy crises and water masses depletions which imperil the Earth's survival, fluids MEHC, QCMEHC and QCNDMEHC combat

the God device said Earth's fluids 'functions', said perimeters' mass energy highest conserving said cadres genres ardently enforce.

Priority: US2008-153036 Applic. Date: 2008-05-13; US2007-809132 Applic. Date: 2007-05-31

Inventor: PETROVICH SVETOZAR B [US]


Application No.: US20100230554A1  Published: 16/Sep/2010

Title: TRASH BAG APPARATUS AND METHOD OF USE

Applicant/Assignee:

Application No.: 12/723599   Filing Date: 12/Mar/2010

Abstract:One possible embodiment of the invention could be a trash bag holder and methodology of operating same, the trash bag holder comprises a resilient strip that is looped to adjustably form a hoop of an desired circumference

a catch mechanism that reversibly fixes the hoop at the desired circumference

a handle with two ends, a first end being pivotally attached to at least a portion of the hoop

wherein the hoop retains and holds open an open mouth portion of a trash bag placed upon the hoop by adjusting the circumference of the hoop to at least meet the circumference of the open mouth portion of the trash bag. The holder may further comprise a base reversibly attached to the handle to respectively orient the hoop parallel to and the handle perpendicular to the ground. The hoop may further encapsulate the base edge in a compact state.

Priority: US20090159794P Applic. Date: 2009-03-12

Inventor: SCOBEY JR FRED BRADLEY [US]


Application No.: US20100233104A1  Published: 16/Sep/2010

Title: Amino-Acid Functional Siloxanes, Methods Of Preparation and Applications

Applicant/Assignee:

Application No.: 12/303784   Filing Date: 16/May/2007

Abstract:A method of preparing an amino acid functional siloxane by reacting an amino acid derivative selected from the group of an N-acyl amino acid and an N-aroyl amino acid with an amino functional siloxane optionally in the presence of a solvent. The invention extends to personal care products containing the resulting amino acid functional siloxanes.

Priority: GB20060011217 Applic. Date: 2006-06-08; WO2007GB50268 Applic. Date: 2007-05-16

Inventor: DRAKE ROBERT [GB]; POSTIAUX STEPHANIE [BE]


Application No.: US20100233162A1  Published: 16/Sep/2010

Title: LOCAL ADMINISTRATION OF CHICKEN YOLK IMMUNE GLOBULINS (IgY) TO TREAT AND PREVENT FUNGAL INFECTIONS

Applicant/Assignee: BENGT AGERUP

Application No.: 12/673379   Filing Date: 28/Aug/2008

Abstract:The present invention relates to a composition comprising IgY antibodies against at least two different fungi, the use of the composition for the preparation of a pharmaceutical especially for prophylaxis and/or therapy of all kinds of fungal infections, such as conditions caused by organisms belonging to the Candida genus or Aspergillus genus, especially of fungi that are less sensitive to antimycotica and a diagnotstic method using the IgY antibodies. Further it relates to immunisation of birds with a combination of at least two different species of fungi to the Candida genus or Aspergillus genus and a diagnostic method for fungi. It also relates to relates to a novel method for treatment and/or prophylaxis of fungal infections, especially infections by fungi which have lowered sensitivity or resistance to antimycotics. The method is both safe and effective. This is achieved by using IgY directed against fungi, in particular against Candida species, which have a lowered sensitivity or resistance against antimycotics. The specific IgY has been obtained by hyper immunising birds with one or several fungi as antigen in order to stimulate the production of immune globulins (IgY) against such fungi. The present invention also relates to a pharmaceutical product from eggs of birds containing immune globulin or a fragment thereof, which can be combined with other preparations, nutritients or pharmaceuticals for simultaneous, separate or sequential use in the prophylaxis or therapy of gastrointestinal infections in newborn infants.

Priority: SE20070001952 Applic. Date: 2007-08-30; US20070968893P Applic. Date: 2007-08-30; WO2008EP61309 Applic. Date: 2008-08-28

Inventor: LARSSON ANDERS [SE]; KOLLBERG HANS [SE]


Application No.: US20100233279A1  Published: 16/Sep/2010

Title: Compositions And Methods Comprising Analogues Of Radicicol A

Applicant/Assignee:

Application No.: 12/663079   Filing Date: 05/Jun/2008

Abstract:Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase-mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase-mediated disorders and synthetic processes for the preparation of the compounds.

Priority: US20070933171P Applic. Date: 2007-06-05; WO2008IB02497 Applic. Date: 2008-06-05

Inventor: WINSSINGER NICOLAS [FR]; BARLUENGA SOFIA [FR]


Application No.: US20100234267A1  Published: 16/Sep/2010

Title: AGENTS CONTAINING PROTEASES FROM STENOTROPHOMONAS MALTOPHILIA

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 12/685215   Filing Date: 11/Jan/2010

Abstract:The present invention relates to agent compositions, in particular washing and cleaning agents, that contain a protease from a bacterial strain of the species Stenotrophomonas maltophilia, and to said proteases themselves. The invention further relates to cleaning methods in which said agents are used, and to uses of said agents. The invention further relates to the manufacture and use of these proteases themselves.

Priority: DE200710033104 Applic. Date: 2007-07-13; WO2008EP58546 Applic. Date: 2008-07-03

Inventor: SIEGERT PETRA [DE]; WIELAND SUSANNE [DE]; MAURER KARL-HEINZ [DE]; BESSLER CORNELIUS [DE]; RIBITSCH DORIS [AT]; HEUMANN SONJA [AT]; GUEBITZ GEORG [AT]; KARL WOLFGANG [AT]; REMLER PETER [AT]; SCHWAB HELMUT [AT]; BERG GABRIELE [AT]; GERLACH JOCHEN [DE]


Application No.: US20100234304A1  Published: 16/Sep/2010

Title: BETA SHEET TAPES RIBBONS IN TISSUE ENGINEERING

Applicant/Assignee: UNIVERSITY OF LEEDS

Application No.: 12/729046   Filing Date: 22/Mar/2010

Abstract:There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a [beta]-sheet tape-like substructure.

Priority: GB20020016286 Applic. Date: 2002-07-15; US2005-521628 Applic. Date: 2005-09-08; WO2003GB03016 Applic. Date: 2003-07-15

Inventor: BODEN NEVILLE [GB]; AGGELI AMALIA [GB]; INGHAM EILEEN [GB]; KIRKHAM JENNIFER [GB]


Application No.: US20100234344A1  Published: 16/Sep/2010

Title: 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS

Applicant/Assignee: JERINI AG

Application No.: 12/532703   Filing Date: 22/Mar/2008

Abstract:The present invention is related to compound of the formula (I): or a pharmacologically acceptable salt, solvate, or hydrate thereof, wherein A is a 6-membered heteroaryl having from 1 to 3 heteroatoms, each independently selected from N or O and the other substituents are defined as in the claims.

Priority: EP20070006089 Applic. Date: 2007-03-23; WO2008EP02316 Applic. Date: 2008-03-22

Inventor: GIBSON CHRISTOPH [DE]; TRADLER THOMAS [DE]; SCHINATBAUM KARSTEN [DE]; PFEIFER JOCHEN [DE]; LOCARDI ELSA [DE]; SCHARN DIRK [DE]; PASCHKE MATHIAS [DE]; REIMER ULF [DE]; RICHTER UWE [DE]; HUMMEL GERD [DE]; REINEKE ULRICH [DE]


Application No.: US20100234549A1  Published: 16/Sep/2010

Title: Radical polymerizable macrocyclic resin compositions with low polymerization stress

Applicant/Assignee:

Application No.: 12/655028   Filing Date: 22/Dec/2009

Abstract:A composition of macrocyclic oligomer with at least one (meth)acrylate polymerizable group. A method includes preparing an activated precursor of an oligomer at pseudo high-dilution conditions. A method also includes preparing an activated precursor of an oligomer by reacting the precursor with an activated coupling agent, wherein the precursor is condensable and polymerizable.

Priority: US2009-381781 Applic. Date: 2009-03-16; US2008-079525 Applic. Date: 2008-03-27; US2005-153090 Applic. Date: 2005-06-15; US20040579836P Applic. Date: 2004-06-15

Inventor: JIN XIAOMING [US]; HAMMESFAHR PAUL D [US]


Application No.: US20100234820A1  Published: 16/Sep/2010

Title: ASPIRATION SYSTEM AND BODY INTERFACE DEVICE FOR REMOVING URINE DISCHARGED BY THE HUMAN BODY

Applicant/Assignee: CONVA TEC TECHNOLOGIES INC

Application No.: 12/738348   Filing Date: 20/Oct/2008

Abstract:A body interface device for a urine aspiration system comprises a skin contact pad with gel adhesive for adhering to the skin, and a flexible cover attached to the pad. The pad includes at least one aperture for admitting urine through the pad into the body interface device. The flexible cover has a bulged form projecting away from the gasket. The flexible cover defines a urine receiving chamber facing towards the gasket, and recess facing away from the chamber for receiving at least a portion of a non-contact liquid sensor. The recess and chamber have a wall portion in common that separates the recess and the chamber. A liquid acquisition material in the chamber receives and transports urine for rapid sensing by the non-contact sensor. An aspiration unit is responsive to the non-contact liquid sensor to apply aspiration suction to the body interface device, upon detection of urine.

Priority: US20070980908P Applic. Date: 2007-10-18; WO2008US80510 Applic. Date: 2008-10-20

Inventor: TSAI MINGLIANG LAWRENCE [US]; NGUYEN-DEMARY TINH [US]


Application No.: US20100234927A1  Published: 16/Sep/2010

Title: LIGHTING APPARATUS OF FACIAL AND LIGHTING METHOD THEREOF

Applicant/Assignee:

Application No.: 12/401914   Filing Date: 11/Mar/2009

Abstract:A lighting apparatus of facial includes a first silica gel layer, a control unit disposed on the first silica gel layer, a lighting module and a second silica gel layer. The lighting module is disposed on the first silica gel layer and includes a plurality of lighting units corresponding to purlieus between a forehead and a nose, a periphery of two eyes, cheeks and a periphery of a mouth of the first silica gel layer. The lighting units are coupled to the control unit. The second silica gel layer is combined with the first silica gel layer to package the control unit and the lighting module. Accordingly, the control unit controls the lighting units corresponding to the purlieus between the forehead and the nose, the periphery of the two eyes, the cheeks and the periphery of the mouth to generate pulsed light with desired wavelength.

Priority:

Inventor: LIN MEI-CHUN [TW]


Application No.: US20100235180A1  Published: 16/Sep/2010

Title: Synergistic Medicodental Outpatient Imaging Center

Applicant/Assignee:

Application No.: 12/401617   Filing Date: 11/Mar/2009

Abstract:The invention discloses a method and configuration for a medical and dental outpatient diagnostic imaging center. The medical and dental diagnostic imaging center will house a plurality of medial and dental modalities within one center. Also, onsite is a CAD/CAM milling unit and the accessory hardware equipment, and the technology used for creating a rapid prototype medical and dental modeling The present invention also includes other technologies and equipment to improve the productivity of the medial and dental outpatient diagnostic imaging center. The unique equipment configuration and the machine sequence pattern offers many benefits to healthcare delivery in that it provides a service for both the fields of medicine and dentistry.

Priority:

Inventor: ATKINSON WILLIAM [US]


Application No.: US20100235930A1  Published: 16/Sep/2010

Title: METHODS OF SELECTING HOST RESISTANT ANIMALS

Applicant/Assignee: OVITA LIMITED

Application No.: 12/664349   Filing Date: 12/Jun/2008

Abstract:The present invention is directed to a method of selecting animals that are genetically resistant to one or more intestinal parasite infections by testing mucus samples for the presence of an antibody against one or more of said intestinal parasites and segregation and selecting the animals that test positive. The animals that test negative are less parasite resistant and can be subjected to parasite management regimes.

Priority: NZ20070555847 Applic. Date: 2007-06-13; NZ20080568017 Applic. Date: 2008-05-06; WO2008NZ00139 Applic. Date: 2008-06-12

Inventor: SHAW RICHARD JOHN [NZ]; CANNON MERIE CHRISTINE [NZ]; ROSANOWSKI SARAH MARGARET [NZ]; WHEELER MARY [NZ]; MORRIS CHRISTOPHER ANTHONY [NZ]


Application No.: US20100236006A1  Published: 23/Sep/2010

Title: Tooth brush

Applicant/Assignee:

Application No.: 12/381787   Filing Date: 17/Mar/2009

Abstract:A tooth brush includes body (18), neck (17), head (16), and bristles (15) at two opposite side of said head pointing opposite away from each other. Said head has plurality of through-all hole (12) for bristle insertion. The middle portion of said through-all hole has smaller diameter compare to entrance. Said head is tapered toward the end. Said bristles are trimmed such that they are tapered toward the end of said head.

Priority:

Inventor: DENG XIAO-MING [US]


Application No.: US20100236019A1  Published: 23/Sep/2010

Title: NOZZLE FOR A FLOOR CLEANING DEVICE

Applicant/Assignee: MIELE & CIE. KG

Application No.: 12/599253   Filing Date: 28/Apr/2008

Abstract:A nozzle for a floor care appliance for cleaning surfaces. The nozzle includes a gliding sole disposed on a bottom side of the floor nozzle and has a suction mouth opening. A suction duct extends from the opening to a connection piece. A front suction mouth edge and a rear suction mouth edge bound the suction mouth with respect to a pushing direction of the floor nozzle. A rear pivot limit stop associated with the rear suction mouth edge and a front pivot limit stop associated with the rear suction mouth edge are included. The rear suction mouth edge projects beyond a plane of contact of the nozzle with the surface when the rear suction mouth edge engages the front pivot limit stop and when the floor nozzle is in a non-contacting position. The front pivot limit stop limits the pivoting angle of the rear suction mouth edge in a direction toward the front suction mouth edge such that the rear suction mouth edge is in a substantially vertical position with respect to the plane of contact when the rear suction mouth edge engages the front pivot limit stop.

Priority: DE200710022256 Applic. Date: 2007-05-09; WO2008EP03413 Applic. Date: 2008-04-28

Inventor: BEHRENSWERTH MARTIN [DE]


Application No.: US20100237115A1  Published: 23/Sep/2010

Title: DIABETIC DISPENSER

Applicant/Assignee: NRGBAND LIMITED

Application No.: 12/161411   Filing Date: 19/Jan/2007

Abstract:A dispenser bracelet wearable on the wrist or arm and for carrying a consumable product for the treatment of the symptoms of hypoglycemia of a diabetic user, the dispenser bracelet comprising: a bracelet body (41) having one or more sealed receptacles (42) for containing said consumable product

one or more access portions (43) provided on a surface of the bracelet body and through which access to the consumable product

and a bite area associated with each of the one or more access portions having a frangible seal for sealing said teats, said seal being frangible by the user biting the bite area for allowing the consumable product to be readily accessed through the one or more access portions by the user's mouth.

Priority: GB20060001086 Applic. Date: 2006-01-19; WO2007GB00169 Applic. Date: 2007-01-19

Inventor: BOOKER ADAM JAY [GB]


Application No.: US20100237281A1  Published: 23/Sep/2010

Title: Peroxide Gel Compositions

Applicant/Assignee: CAO GROUP, INC

Application No.: 12/797490   Filing Date: 09/Jun/2010

Abstract:The present invention is the use of Poly(2-ethyl-2-oxazoline) in the creation of peroxide gels for various applications. Such applications include bleaching of hair, teeth, laundry or any other bleachable item. Blending of the gel is accomplished by mixing the Poly(2-ethyl-2-oxazoline) with a peroxide such as hydrogen peroxide, carbamide peroxide, sodium perborate, or sodium percarbonate, usually also with water or an appropriate organic solvent. Peroxide concentrations in these new gels can reach a 30% concentration of hydrogen peroxide while maintaining a shelf life of six months at room temperature without developing peroxide decomposition.

Priority: US2006-307463 Applic. Date: 2006-02-08

Inventor: JENSEN STEVEN D [US]


Application No.: US20100239608A1  Published: 23/Sep/2010

Title: PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS

Applicant/Assignee: CUREVAC GMBH

Application No.: 12/787755   Filing Date: 26/May/2010

Abstract:The present invention relates to a pharmaceutical composition containing an mRNA that is stabilised by sequence modifications in the translated region and is optimised for the translation. The pharmaceutical composition according to the invention is particularly suitable as an inoculating agent as well as a therapeutic agent for tissue regeneration. In addition a process is described for determining sequence modifications that serve for the stabilisation and translation optimisation of mRNA.

Priority: DE20011027283 Applic. Date: 2001-06-05; US2003-729830 Applic. Date: 2003-12-05; WO2002EP06180 Applic. Date: 2002-06-05

Inventor: VON DER MUELBE FLORIAN [DE]; HOERR INGMAR [DE]; PASCOLO STEVE [CH]


Application No.: US20100239629A1  Published: 23/Sep/2010

Title: Delivery system for delivering bioactive materials

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 11/496599   Filing Date: 31/Jul/2006

Abstract:A delivery system for delivering bioactive materials as an aqueous nanoparticle dispersion of a water soluble matrix of polyvinylpyrrolidone (PVP) polymer and copolymers thereof, and an anionic surfactant.

Priority:

Inventor: NARAYANAN KOLAZI S [US]; JON DOMINGO [US]; PATEL JAYANTI [US]; WINKOWSKI KAREN [US]


Application No.: US20100239633A1  Published: 23/Sep/2010

Title: IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS

Applicant/Assignee: UNIVERSITY OF MARYLAND BALTIMORE

Application No.: 12/602609   Filing Date: 30/May/2008

Abstract:IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.

Priority: US20070941644P Applic. Date: 2007-06-01; US20070015127P Applic. Date: 2007-12-19; US20070015547P Applic. Date: 2007-12-20; WO2008US65428 Applic. Date: 2008-05-30

Inventor: STROME SCOTT E [US]; SCHULZE DAN H [US]; BLOCK DAVID S [US]


Application No.: US20100239785A1  Published: 23/Sep/2010

Title: DEVICE AND APPARATUS FOR SELECTIVE DEPOSITION OF MOLTEN PLASTIC MATERIAL AND METHOD OF MANUFACTURE BY SELECTIVE DEPOSITION

Applicant/Assignee: FUNDACIO PRIVADA ASCAMM

Application No.: 12/676423   Filing Date: 25/Aug/2008

Abstract:Device and apparatus for selective deposition of molten plastic material and method of manufacture by selective deposition. The device and the apparatus include a melting chamber communicated with a portion of a sonotrode of an ultrasonic transducer, a passage for feeding plastic material, and at least one outlet opening for supplying molten plastic material dropwise or continuously. A feeding of plastic material to the melting chamber is provided. The method includes feeding plastic material to the melting chamber configured in a device for selective deposition installed in a head of a piece of industrial manufacturing equipment, which is moved according to a strategy of its path defined by numerical control on a deposition area, and pouring plastic material melted by ultrasound through the outlet opening.

Priority: ES20070002390 Applic. Date: 2007-09-04; WO2008ES00570 Applic. Date: 2008-08-25

Inventor: PLANTA TORRALBA FRANCISCO XAVIER [ES]; PULIGA FRANCESCO [ES]; PALLARES BEJARANO ALVARO [ES]


Application No.: US20100239996A1  Published: 23/Sep/2010

Title: METHOD FOR DETERMINING THE POSITION OF AN INTRAORAL MEASURING DEVICE

Applicant/Assignee: DEGUDENT GMBH

Application No.: 12/677601   Filing Date: 12/Sep/2008

Abstract:A method for determining the position of an intraoral measuring device which is to be moved relative to an organ of mastication of a patient and with which positions in the organ of mastication or areas of the organ of mastication are measured. To be able to carry out measurements without a fixed reference, it is proposed that, independently of a reference that is independent of the patient, the position of the measuring device is measured by means of a position-determining sensor that is in a fixed relationship to the measuring device.

Priority: DE200710043366 Applic. Date: 2007-09-12; WO2008EP62116 Applic. Date: 2008-09-12

Inventor: ERTL THOMAS [DE]


Application No.: US20100240714A1  Published: 23/Sep/2010

Title: ORAL COMPOSITION FOR DENTAL PURPOSES

Applicant/Assignee: NAT. UNI. CORP. OKAYAMA UNIVERSITY

Application No.: 12/374215   Filing Date: 18/Jul/2007

Abstract:A dental composition for oral use, containing a phosphorylated saccharide (a), a cationic bactericidal agent (b) and a solvent (c). By using the dental composition for oral use of the present invention, the adhesion of the bacteria in the oral cavity to the surfaces of the teeth can be suppressed for a long period of time

therefore, the dental composition for oral use can be suitably used for, for example, a mouse-wash agent, a dentifrice agent, a gargling agent, a mouse spray, a coating agent or a bonding agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, or the like.

Priority: JP20060198367 Applic. Date: 2006-07-20; WO2007JP64185 Applic. Date: 2007-07-18

Inventor: YOSHIDA YASUHIRO [JP]; NAMBA NAOKO [JP]; NAGAOKA NORIYUKI [JP]; YOSHIMOTO KAORI [JP]; TAKASHIBA SHOGO [JP]; SUZUKI KAZUOMI [JP]; ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]


Application No.: US20100240746A1  Published: 23/Sep/2010

Title: STEREOISOMERS OF TRICYCLODECAN-9-YL-XANTHOGENATE

Applicant/Assignee: LUMAVITA AG

Application No.: 12/666282   Filing Date: 03/Jul/2008

Abstract:Provided herein are optically active stereoisomers of tricylclodecan-9-yl xanthogenate, processes of preparation, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease caused by a virus.

Priority: US20070958370P Applic. Date: 2007-07-03; WO2008EP05460 Applic. Date: 2008-07-03

Inventor: TOMIOKA MIYUKI [CH]; HASEGAWA KO [JP]


Application No.: US20100240774A1  Published: 23/Sep/2010

Title: USE OF HYDROPHOBIN POLYPEPTIDES AS PENETRATION ENHANCERS

Applicant/Assignee: BASF SE

Application No.: 12/721973   Filing Date: 11/Mar/2010

Abstract:The present invention relates to the use of hydrophobin polypeptides as penetration intensifiers.

Priority: EP20070116363 Applic. Date: 2007-09-13; EP20070121650 Applic. Date: 2007-11-27; WO2008EP60870 Applic. Date: 2008-08-20

Inventor: SUBKOWSKI THOMAS [DE]; KAROS MARVIN [DE]; BARG HEIKO [DE]; BOLLSCHWEILER CLAUS [DE]


Application No.: US20100240794A1  Published: 23/Sep/2010

Title: DENTAL RESIN COMPOSITION, METHOD OF MANUFACTURE, AND METHOD OF USE THEREOF

Applicant/Assignee:

Application No.: 12/408373   Filing Date: 20/Mar/2009

Abstract:Disclosed herein are curable (meth)acrylate resins for dental compositions obtained by reacting an anhydride with an alcohol or an amine to obtain a carboxy ester or a carboxy amide and reacting the carboxy ester or carboxy amide with a (meth)acrylate monomer comprising an epoxide group or an oxetane group.

Priority:

Inventor: JIN SHUHUA [US]; JIA WEITAO [US]


Application No.: US20100240795A1  Published: 23/Sep/2010

Title: SELF-ADHESIVE MULTICOMPONENT DENTAL MATERIAL

Applicant/Assignee: IVOCLAR VIVADENT AG

Application No.: 12/499961   Filing Date: 09/Jul/2009

Abstract:Curable multicomponent dental material, including a first paste, which contains (i) one or more acid group-free radically polymerizable monomers and (ii) basic filler, and a second paste, which contains (iii) one or more acid group-containing radically polymerizable monomers and (iv) non-basic filler, wherein the multicomponent dental material contains at least one initiator (v) for radical polymerization in at least paste (A) or (B).

Priority: EP20090155935 Applic. Date: 2009-03-23; EP20090156063 Applic. Date: 2009-03-24

Inventor: BURTSCHER PETER [AT]; EDER MARION [AT]; KAMMANN AXEL [AT]


Application No.: US20100240796A1  Published: 23/Sep/2010

Title: UNIVERSAL DENTAL ADHESION-PROMOTER COMPOSITION

Applicant/Assignee: IVOCLAR VIVADENT AG

Application No.: 12/491815   Filing Date: 25/Jun/2009

Abstract:The invention relates to an adhesion-promoter composition for the adhesive joining of metallic or ceramic dental materials to radically curing dental materials, wherein the adhesion-promoter composition contains an alkoxysilane monomer (i), a phosphoric acid ester monomer (ii), a sulphur-containing monomer (iii) and an organic solvent (iv).

Priority: EP20090155324 Applic. Date: 2009-03-17

Inventor: BOCK THORSTEN [AT]; MOSZNER NORBERT [LI]; RHEINBERGER VOLKER M [LI]; SALZ ULRICH [DE]; ZEUNER FRANK [LI]


Application No.: US20100240798A1  Published: 23/Sep/2010

Title: REDOX-CURING TYPE NONAQUEOUS CURABLE COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/789997   Filing Date: 28/May/2010

Abstract:The present invention relates to processes of making a cured dental adhesive compositions, in contact with a wetting material surface, by contacting the wetting material surface having water present on the surface with a nonaqueous composition including at least one liquid radical polymeric monomer (a), an organic peroxide (b), and a water-soluble reducing compound (c) in the form of a solid, where the water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a)

and solvating the water-soluble reducing compound (c) present at an interface between the redox-curing nonaqueous curable composition and the wetting material with the water present on the wetting material surface.

Priority: JP20040232731 Applic. Date: 2004-08-09; US2007-659805 Applic. Date: 2007-02-09; WO2005JP14502 Applic. Date: 2005-08-08

Inventor: KAWASHIMA MITSUNOBU [JP]; TAKASE AKI [DE]


Application No.: US20100240914A1  Published: 23/Sep/2010

Title: Radical polymerizable macrocyclic resin compositions with low polymerization stress

Applicant/Assignee:

Application No.: 12/655626   Filing Date: 04/Jan/2010

Abstract:A composition of macrocyclic oligomer with at least one polymerizable group, (meth)acrylate, for example.

Priority: US2009-381860 Applic. Date: 2009-03-17; US2008-079987 Applic. Date: 2008-03-31; US2005-153089 Applic. Date: 2005-06-15; US20040579837P Applic. Date: 2004-06-15

Inventor: JIN XIAOMING [US]; HAMMESFAHR PAUL D [US]


Application No.: US20100241198A1  Published: 23/Sep/2010

Title: Tubular device delivering light and radiation into a patient

Applicant/Assignee:

Application No.: 12/661551   Filing Date: 19/Mar/2010

Abstract:A device delivers light within a patient using an inner cannula, fiber optics, LED along an endotracheal tube, ETT or tracheostomy tube or a strip with embedded LED adhered to an ETT. The inner cannula includes a tubular thin walled device that transmits light by fiber optics or delivers electrical power to an LED. The light passes along one or more fibers placed within the walls of the inner cannula for outward delivery of the light. The light affects the inside of the cannula, the area between the cannula and the ETT, the area outside the ETT, and into the tracheobronchial tree. The light delivers an antimicrobial effect into the upper airway of a patient. Alternatively, the light delivery device involves tubes and cannulas attaching to existing medical tubes and devices. Alternatively, a transparent strip of embedded LED secures to an existing medical tube.

Priority: US20090210515P Applic. Date: 2009-03-20

Inventor: KLEPPER MARK [US]


Application No.: US20100242859A1  Published: 30/Sep/2010

Title: METHOD OF TRAINING A DOG TO CHEW ACCEPTABLE OBJECTS THROUGH SCENT MARKING AND CHEMICAL COMPOSITION THEREOF

Applicant/Assignee: SCENTS-ABILITY, LLC

Application No.: 12/570313   Filing Date: 30/Sep/2009

Abstract:A positive-reinforced method of training a dog to chew or mouth only appropriate household items and chew toys. The method includes scent-training the dog (or puppy) to recognize a particular distinctive scent not normally found in nature as applied to an acceptable chewing object. The dog is introduced to the distinctive scent and encouraged to chew the marked acceptable chewing object. Each time the dog recognizes the scent, the dog is encouraged to chew the scented chewing object or some other acceptable chewing object marked with the distinctive scent and rewarded. The dog is tested with at least one unmarked object. The dog is trained once the dog can discriminate between the scent-marked object or objects and the unmarked object or objects. From there, the scent may be applied to other household items that are acceptable chewing/mouthing items (e.g., other chew toys). By absence of the scent, the dog recognizes that it cannot chew on unacceptable items (e.g., furniture, shoes). The scent may be applied to acceptable chewing/mouthing items in liquid form or as a gel. The scent is aromatic to dogs but not to people. The invention also includes the chemical composition of the scent used in the method training. The preferred chemical composition comprises of one part animal secretion, one part disparate animal secretion, and three parts aqueous solution.

Priority: US20080109925P Applic. Date: 2008-10-31

Inventor: RAYMOND LAUREL D [US]


Application No.: US20100242978A1  Published: 30/Sep/2010

Title: SMOKELESS TOBACCO PRODUCT

Applicant/Assignee:

Application No.: 12/757960   Filing Date: 09/Apr/2010

Abstract:A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. A smokeless tobacco product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and tobacco, the sheet being soluble in a user's mouth and resulting in sustained release of nicotine to the user. The sheet can be in a form that may be placed in the buccal cavity of, on the palate of or sublingually in the user, and have an average dissolution time of 5 to 50 minutes for delivering super bioavailable nicotine to the user.

Priority: WO2008US11374 Applic. Date: 2008-10-02; US20070979169P Applic. Date: 2007-10-11; US20070990381P Applic. Date: 2007-11-27; US20080054195P Applic. Date: 2008-05-19

Inventor: FUISZ RICHARD C [US]


Application No.: US20100243777A1  Published: 30/Sep/2010

Title: MEAT MINCING AND MIXING MACHINE HAVING DUAL MODE OPERATION

Applicant/Assignee:

Application No.: 12/728717   Filing Date: 22/Mar/2010

Abstract:A meat mincing and mixing machine with a dual mode operation has a tilting mixing vat with inner rotating mixing blade fixed to a longitudinal horizontal axis, a unit for actuating the tilting mixing vat, a support and fixation device for supporting the axle detachably together with the mixing blades for cleaning and maintenance, a mincing body supporting the vat, separated by a sliding track door, and provided with a mincing spindle located inside the mincing body with a horizontal axis and a longitudinal direction, parallel to the longitudinal horizontal axle of the mixing blades and aligned against a front exit mouth, a protective casing covering the front exit mouth and rotating about a lower axle, a unit for actuating the mincing spindle, a folding screen provided at the rear of the vat and protecting against splattering, and actuation controls.

Priority: ES20090000623U Applic. Date: 2009-03-30

Inventor: VILA BONAS JUAN [ES]


Application No.: US20100247454A1  Published: 30/Sep/2010

Title: COMPOSITIONS FOR ELASTOGENESIS AND CONNECTIVE TISSUE TREATMENT

Applicant/Assignee:

Application No.: 12/686330   Filing Date: 12/Jan/2010

Abstract:The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.

Priority: US2005-062377 Applic. Date: 2005-02-22; US20040546682P Applic. Date: 2004-02-20; US20040622104P Applic. Date: 2004-10-26

Inventor: MITTS THOMAS [US]; JIMENEZ FELIPE [US]; HINEK ALEKSANDER [CA]; BUNDA SEVERA [CA]


Application No.: US20100247456A1  Published: 30/Sep/2010

Title: METHODS AND COMPOSITIONS FOR PREVENTING CARIES

Applicant/Assignee:

Application No.: 12/726059   Filing Date: 17/Mar/2010

Abstract:The present invention relates to an anti-caries composition that includes Silver Diamine Fluoride (SDF) and a carrier, and methods for using the composition. In particular, the composition includes SDF in an amount between about 1% and about 40% by weight

and a carrier (e.g., natural adhesive, a synthetic adhesive, a drying adhesive, an emulsion adhesive, silicone, copal, glass ionomer, cyanoacrylate, composite resin, latex, epoxy, silicone, polyurethane, denture adhesives, or variants thereof or any combination thereof. The methods of the present invention relate to arresting caries or reducing the number of active caries lesions. The steps include applying the anti-caries SDF composition to one or more tooth surfaces for about 1-5 minutes, and rinsing the composition from the tooth surface. Another method of the present invention relates to applying a SDF composition to the tooth surface, curing the composition, to thereby treat caries. Caries is arrested or the number of active caries lesions is reduced, as compared to an individual whose tooth surface is not subjected to the SDF composition.

Priority: US20090161389P Applic. Date: 2009-03-18

Inventor: NIEDERMAN RICHARD [US]; ROSENBLATT ARONITA [BR]


Application No.: US20100247461A1  Published: 30/Sep/2010

Title: ANTI-INFLAMMATORY COMPLEXES

Applicant/Assignee: SIGNUM BIOSCIENCES, INC

Application No.: 12/690906   Filing Date: 20/Jan/2010

Abstract:Disclosed are certain complexes of AFC compounds and binding agents. Such complexes are useful, among other things, in the treatment of inflammatory diseases or disorders.

Priority: US20090145887P Applic. Date: 2009-01-20

Inventor: VORONKOV MICHAEL [US]; STOCK JEFFRY B [US]; STOCK MAXWELL [US]; LEE SEUNG-YUB [US]; PEREZ EDUARDO [US]; GORDON JOEL S [US]


Application No.: US20100247571A1  Published: 30/Sep/2010

Title: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS

Applicant/Assignee: ACADEMIA SINICA

Application No.: 12/748265   Filing Date: 26/Mar/2010

Abstract:Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

Priority: US20090164385P Applic. Date: 2009-03-27; US20090164387P Applic. Date: 2009-03-28; US20090164388P Applic. Date: 2009-03-28; US20090164389P Applic. Date: 2009-03-28; US20100313676P Applic. Date: 2010-03-12

Inventor: WONG CHI-HUEY [TW]; MA CHE [TW]; WANG CHENG-CHI [TW]; CHEN JUINE-RUEY [TW]


Application No.: US20100247586A1  Published: 30/Sep/2010

Title: Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties

Applicant/Assignee:

Application No.: 12/430238   Filing Date: 27/Apr/2009

Abstract:A multi portion intra-oral dosage form has at least one pharmaceutically active agent or health promoting agent with at least one portion comprises a component for creating a noticeable organoleptic sensation. The sensory markers or signals are conceptual aids for a subject using the dosage form where the organoleptic sensation is such that it facilitates the subject to identify a portion and differentiate between different portions. Also contemplated are a dosage form, a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N'-oxide, nomicotine, (S)-nicotine-N-[beta]-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said dosage forms.

Priority: SE20090000397 Applic. Date: 2009-03-27

Inventor: HUGERTH ANDREAS [SE]; NICKLASSON FREDRIK [SE]; LINDELL KATARINA [SE]; THYRESSON KRISTINA [SE]


Application No.: US20100247612A1  Published: 30/Sep/2010

Title: EXTRUDABLE AND EXTRUDED COMPOSITIONS FOR DELIVERY OF BIOACTIVE AGENTS, METHOD OF MAKING SAME AND METHOD OF USING SAME

Applicant/Assignee:

Application No.: 12/757936   Filing Date: 09/Apr/2010

Abstract:A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. An extruded bioactive product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and a bioactive agent, the sheet being soluble in a user's mouth and resulting in sustained release of bioactive to the user. The sheet can be in a form that may be placed in contact with the mucosa of the user, and have an average dissolution time of 5 to 50 minutes for delivering the bioactive to the user.

Priority: WO2008US11374 Applic. Date: 2008-10-02; WO2008US11634 Applic. Date: 2008-10-10; US20070979169P Applic. Date: 2007-10-11; US20070990381P Applic. Date: 2007-11-27; US20080054195P Applic. Date: 2008-05-19

Inventor: FUISZ RICHARD C [US]


Application No.: US20100247738A1  Published: 30/Sep/2010

Title: CURABLE ZIRCONIA ADHESIVE COMPOSITIONS FOR DENTAL RESTORATIONS

Applicant/Assignee: BISCO, INC

Application No.: 12/412937   Filing Date: 27/Mar/2009

Abstract:The present application relates to a polymerizable dental adhesive system formulated for effective and durable bonding of zirconia based materials and restorations to dental resins and dental surfaces. According to one embodiment, a polymerizable dental adhesive system comprises a first acidic monomer comprising an ethylenically unsaturated polymerizable group or moiety of the general formula CH2-CX-C(O)- wherein X is hydrogen, methyl or a lower alkyl group, and the first polymerizable monomer further comprises a phosphoric or phosphonic acid group of general formula -OP(O)(OH)2, -OP(O)(OH), -C-P(O)(OH)2 and -C-P(O)(OH), and a second polymerizable acidic monomer comprises an ethylenically unsaturated polymerizable group or moiety of the general formula CH2-CX-C(O)- wherein X is hydrogen, methyl or a lower alkyl group, and wherein the second polymerizable acidic monomer further comprises a carboxylic acid group of the general formula -C(O)OH.

Priority:

Inventor: SUH BYOUNG I [US]; CHEN LIANG [US]


Application No.: US20100248183A1  Published: 30/Sep/2010

Title: Denture adhesive shield

Applicant/Assignee:

Application No.: 12/661191   Filing Date: 12/Mar/2010

Abstract:Disclosed is a denture shield to prevent denture adhesive from coming in contact with the user's gums and/or oral mucosa including the palate. This shield has two important advantages, the first is the elimination of the hard and messy cleanup of the residue from the user's mouth and the second is the reduction of the adhesive chemicals into the user's system.

Priority: US20090211340P Applic. Date: 2009-03-30

Inventor: TUDEK ARTHUR L [US]; DAUGHERTY RENEE R [US]


Application No.: US20100249019A1  Published: 30/Sep/2010

Title: USE OF A PEPTIDE AS A THERAPEUTIC AGENT

Applicant/Assignee:

Application No.: 12/677805   Filing Date: 09/Sep/2008

Abstract:The present invention is directed to the use of the combination of the peptide compounds Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-OH and VaI-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 as a therapeutic combination for prophylaxis and/or treatment of cancer, a heart and vascular disease, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, or an autoimmune disease.

Priority: EP20070017754 Applic. Date: 2007-09-11; EP20070017766 Applic. Date: 2007-09-11; WO2008EP08160 Applic. Date: 2008-09-09

Inventor: BEVEC DORIAN [DE]; CAVALLI FABIO [CH]; CAVALLI VERA [CH]; BACHER GERALD [DE]


Application No.: US20100249034A1  Published: 30/Sep/2010

Title: GFRALPHA3 AND ITS USES

Applicant/Assignee:

Application No.: 12/698324   Filing Date: 02/Feb/2010

Abstract:The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFR[alpha]3, a novel [alpha]-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an [alpha]-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced [alpha]-subunit receptor homo-dimerization or homo-oligomerization.

Priority: US2006-529680 Applic. Date: 2006-09-27; US2006-448387 Applic. Date: 2006-06-06; US2003-621855 Applic. Date: 2003-07-16; US1999-272835 Applic. Date: 1999-03-19; US19980079124P Applic. Date: 1998-03-23; US19980081569P Applic. Date: 1998-04-13

Inventor: DE SAUVAGE FREDERIC J [US]; KLEIN ROBERT D [US]; PHILLIPS HEIDI S [US]; ROSENTHAL ARNON [US]


Application No.: US20100249105A1  Published: 30/Sep/2010

Title: INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/727723   Filing Date: 19/Mar/2010

Abstract:The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Priority: US2009-568085 Applic. Date: 2009-09-28; US20080101054P Applic. Date: 2008-09-29; US20090225452P Applic. Date: 2009-07-14

Inventor: SCHRIMPF MICHAEL R [US]; LEE CHIH-HUNG [US]; LI TAO [US]; GFESSER GREGORY A [US]; MORTELL KATHLEEN H [US]; FAGHIH RAMIN [US]; NERSESIAN DIANA L [US]; SIPPY KEVIN B [US]; BUNNELLE WILLIAM H [US]; SCANIO MARC [US]; SHI LEI [US]; GOPALAKRISHNAN MURALI [US]; DONNELLY-ROBERTS DIANA L [US]; HU MIN [US]


Application No.: US20100249203A1  Published: 30/Sep/2010

Title: COMPOUNDS THAT INHIBIT TRPV1 AND USES THEREOF

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/815259   Filing Date: 14/Jun/2010

Abstract:Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Priority: US2007-844712 Applic. Date: 2007-08-24; US20060840254P Applic. Date: 2006-08-25

Inventor: LEE CHIH-HUNG [US]; PERNER RICHARD J [US]; BROWN BRIAN S [US]; DARBYSHIRE JOHN [CH]


Application No.: US20100249207A1  Published: 30/Sep/2010

Title: SYNTHESIS OF PYRROLIDINE COMPOUNDS

Applicant/Assignee: WYETH LLC

Application No.: 12/690043   Filing Date: 19/Jan/2010

Abstract:Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Priority: US2007-005118 Applic. Date: 2007-12-20; US20060876290P Applic. Date: 2006-12-21

Inventor: ALIMARDANOV ASAF R [US]; KRISHNAN LALITHA [US]; ZHOU MAOTANG [US]; WANG TING-ZHONG [US]; REN JIANXIN [US]; CONSIDINE JOHN LEO [US]; WU CHARLES C [US]; BRAZZILLO JASON [US]; RAVEENDRANATH PANOLIL [US]; SUTHERLAND KAREN [US]; MIRMEHRABI MAHMOUD [CA]; DESHMUKH SUBODH S [US]; RAVEENDRANATH GIRIJA [US]; RAVEENDRANATH VIJAY [US]; RAVEENDRANATH SANJAY [US]


Application No.: US20100249231A1  Published: 30/Sep/2010

Title: HSP90 Inhibitors of Protein-Protein Interaction HSP90 Chaperone Complexes and Therapeutic Uses Thereof

Applicant/Assignee: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

Application No.: 12/741430   Filing Date: 10/Nov/2008

Abstract:A novel Hsp90 inhibitor that disrupts protein-protein interaction in a Hsp90 superchaperone complex without blocking ATP binding and methods for treating diseases such as pancreatic cancer are disclosed.

Priority: US20070002610P Applic. Date: 2007-11-09; WO2008US82937 Applic. Date: 2008-11-10

Inventor: SUN DUXIN [US]; ZHANG TAO [US]


Application No.: US20100249276A1  Published: 30/Sep/2010

Title: CURATIVES FOR EPOXY COMPOSITIONS

Applicant/Assignee: DESIGNER MOLECULES, INC

Application No.: 12/815896   Filing Date: 15/Jun/2010

Abstract:The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.

Priority: US2009-595505 Applic. Date: 2009-10-09; WO2008US59804 Applic. Date: 2008-04-09; US20090186894P Applic. Date: 2009-06-15; US20070922412P Applic. Date: 2007-04-09; US20070930166P Applic. Date: 2007-05-15

Inventor: DERSHEM STEPHEN M [US]


Application No.: US20100249305A1  Published: 30/Sep/2010

Title: SLIP FOR THE PREPARATION OF DENTAL CERAMICS BY A HOT-MELT INKJET PRINTING PROCESS

Applicant/Assignee: IVOCLAR VIVADENT AG

Application No.: 12/498806   Filing Date: 07/Jul/2009

Abstract:Slip for use in a hot-melt inkjet printing process which contains (A) ceramic particles, (B) wax and (C) at least one radically polymerizable monomer, and use of the slip to prepare dental restorations. Furthermore, a process for the preparation of a green compact is described, in which the slip is moulded in layers to the geometrical shape of the green compact and subjected to a radical polymerization in order to obtain a cured green compact.

Priority: EP20090156533 Applic. Date: 2009-03-27

Inventor: LAUBERSHEIMER JURGEN [CH]; ZAPPINI GIANLUCA [IT]; RHEINBERGER VOLKER M [LI]


Application No.: US20100249927A1  Published: 30/Sep/2010

Title: MEDICAL DEVICES WITH GALVANIC PARTICULATES

Applicant/Assignee:

Application No.: 12/731848   Filing Date: 25/Mar/2010

Abstract:Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting.

Priority: US20090163928P Applic. Date: 2009-03-27

Inventor: YANG CHUNLIN [US]; SUN YING [US]; CICHOCKI JR FRANK R [US]; BAR SAUMEN N [US]; HAUSCHILD JAMES E [US]; HERZBERG URI [US]; LI YUFU [US]; MING XINTIAN [US]; KONG WEI [US]


Application No.: US20100254915A1  Published: 07/Oct/2010

Title: DENTAL CLEANING AND POLISHING COMPOSITION COMPRISING DIAMOND PARTICLES

Applicant/Assignee:

Application No.: 12/418927   Filing Date: 06/Apr/2009

Abstract:A new whitening dentifrice suitable for use with porcelain veneers and dental work as well as with natural tooth enamel comprising diamond particles is disclosed.

Priority:

Inventor: KAO LISA MARIE [US]


Application No.: US20100254918A1  Published: 07/Oct/2010

Title: AGENT FOR THE PREVENTION AND TREATMENT OF THE INITIAL DENTAL CARIES

Applicant/Assignee: GORAM SPOL. S R.O

Application No.: 12/173894   Filing Date: 16/Jul/2008

Abstract:A composition for the prevention and treatment of initial tooth caries, that is composed of a phosphate-calcium gel with the Ca/P mass ratio ranging from 1.2 to 1.5 and with a bond energy of the 2p phosphorus electron of 131 eV to 136 eV and optionally containing at least one auxiliary dental substance. The composition can further contain an aqueous solution of methyl cellulose or/and chlorohexidine gluconate.

Priority: CZ20060000040 Applic. Date: 2006-01-19; WO2006CZ00091 Applic. Date: 2006-12-14

Inventor: MARYSKA MARTIN [CZ]; MARYSKA JAN [CZ]; MARYSKOVA JITKA [CZ]


Application No.: US20100255088A1  Published: 07/Oct/2010

Title: Method for delivering a combination of resveratrol and aspirin for use in treatment and prevention of vascular disease

Applicant/Assignee:

Application No.: 12/798466   Filing Date: 05/Apr/2010

Abstract:A method for delivering a composition for use in treatment and prevention of vascular disease by providing a vehicle for delivery of the composition to an individual, wherein the composition contains a combination of aspirin and resveratrol

administering the vehicle to the mouth of the individual, wherein the vehicle melts at the body temperature of the individual such that the aspirin and resveratrol is absorbed thru the oral mucosa and delivered directly into the inidvidual's bloodstream

and a related melting capsule comprised of a material that has the same melting point as the human body temperature and includes aspirin in the range of 81 to 325 mg and resveratrol in the range of 10 to 300 mg.

Priority: US20090212006P Applic. Date: 2009-04-06

Inventor: OVIL YOEL [ZA]


Application No.: US20100255119A1  Published: 07/Oct/2010

Title: Mucositis Prevention Supplement and Treatment

Applicant/Assignee:

Application No.: 12/755687   Filing Date: 07/Apr/2010

Abstract:The present invention provides for a nutritional composition comprising from 0.25 g to 25 g of glutamine, in neutral or salt form or precursor or derivative thereof

and from 0.1 g to 10 g of a phytochemical or a mixture thereof, wherein the phytochemical is an antioxidant. The nutritional composition is particularly useful in the treatment and/or prevention of mucositis.

Priority: EP20090005111 Applic. Date: 2009-04-07

Inventor: SCHNEID CHRISTINA [DE]


Application No.: US20100255443A1  Published: 07/Oct/2010

Title: Dental retraction material having enhanced fluid absorption

Applicant/Assignee: CENTRIX, INC

Application No.: 12/798396   Filing Date: 02/Apr/2010

Abstract:A retraction material promoting both retraction and drying of the gingival sulcus around a tooth. The retraction material comprises an astringent and an absorbing or drying agent. The retraction material is placed with a syringe and capsule around the gingival sulcus prior to the taking of an impression in a dental procedure.

Priority: US2007-825802 Applic. Date: 2007-07-09; WO2007US08232 Applic. Date: 2007-03-30; US20090212005P Applic. Date: 2009-04-06

Inventor: DRAGAN WILLIAM B [US]


Application No.: US20100255447A1  Published: 07/Oct/2010

Title: ADVANCED BIO-COMPATIBLE POLYMER SURFACE COATINGS FOR IMPLANTS AND TISSUE ENGINEERING SCAFFOLDS

Applicant/Assignee: UNIVERSITY OF ARKANSAS

Application No.: 12/604964   Filing Date: 23/Oct/2009

Abstract:Disclosed herein are methodologies and compositions for coating materials, which can be used in a variety of biological applications.

Priority: US20090212110P Applic. Date: 2009-04-07

Inventor: BIRIS ALEXANDRU S [US]; JENSEN PEDER [US]; KANNARPADY GANESH [US]


Application No.: US20100256040A1  Published: 07/Oct/2010

Title: COMPOSITION AND METHOD FOR TREATING VIRAL INFECTION

Applicant/Assignee: MYRIAD GENETICS, INCORPORATED

Application No.: 11/625200   Filing Date: 19/Jan/2007

Abstract:Methods for inhibiting virus propagation and treating virus infection are provided which include administering to cells infected with viruses a compound capable of inhibiting viral budding from the cells.

Priority: US2002-224999 Applic. Date: 2002-08-20; US20010313695P Applic. Date: 2001-08-20

Inventor: MORHAM SCOTT [US]; ZAVITZ KENTON [US]; HOBDEN ADRIAN [US]


Application No.: US20100256219A1  Published: 07/Oct/2010

Title: Small interfering DNA (siDNA) oligonucleotides as an antiviral agent against Herpes virus infections

Applicant/Assignee: UNIVERSITY OF ZUERICH

Application No.: 12/748897   Filing Date: 29/Mar/2010

Abstract:Disclosed is an antiviral agent which can be effectively used against Herpes virus. The agent includes siDNA that can bind to Herpes virus target RNA. The siDNA oligonucleotides comprise generally an antisense strand that is complementary to Herpes virus target RNA which is linked via a thymidine linker to a second strand that is partially complementary to the antisense-strand.

Priority: EP20090075162 Applic. Date: 2009-04-01

Inventor: MOELLING KARIN [DE]


Application No.: US20100256575A1  Published: 07/Oct/2010

Title: ADAPTER FOR CANNULAS FOR DISPENSING PRODUCTS AND CANNULA THEREFOR

Applicant/Assignee:

Application No.: 12/734650   Filing Date: 24/Nov/2008

Abstract:Adapter (3) for cannulas (2) for dispensing products comprising a first hollow substantially cylindrical portion (31) provided inside with means for fastening to a bottle (4) containing such products to be dispensed with the cannula and a second cylindrical portion (32) that joins to the first portion having a channel (33) that connects to an opening located on the mouth (41) of the bottle (4) and that is suitable for receiving the end portion of the cannula.

Priority: IT2007MI02251 Applic. Date: 2007-11-29; WO2008IB03298 Applic. Date: 2008-11-24

Inventor: NOBBIO ALESSIO [IT]; BLANCO LOUSAME DOLORES [ES]; MOSCOSO DEL PRADO JAIME [ES]


Application No.: US20100256649A1  Published: 07/Oct/2010

Title: METHOD FOR PRODUCING A DRILL ASSISTANCE DEVICE FOR AT LEAST ONE IMPLANT HOLE IN A BONE STRUCTURE AND DEVICE OBTAINED

Applicant/Assignee:

Application No.: 12/602634   Filing Date: 03/Jun/2008

Abstract:According to this method, one makes a three-dimensional solid reproduction (12) of the anatomical zone of implantation and, from this reproduction, a drill assistance device (30) comprising a rigid base (35) provided with at least one drill guide (34, 38). According to the invention,-the three-dimensional solid reproduction (12) consists of a reproduction of an internal and peripheral portion of said bone structure, exempt, at least in the vicinity of each implant hole, from the surrounding non-osseous tissues and mucosa,-said rigid base (35) having at least one surface, called contact surface, adapted to be able to bear in contact with an external surface portion of the three-dimensional solid reproduction (12), and therefore also later in contact with a peripheral surface portion of said bone structure.

Priority: FR20070003939 Applic. Date: 2007-06-04; US20070982152P Applic. Date: 2007-10-24; WO2008IB52161 Applic. Date: 2008-06-03

Inventor: CAPSAL JEAN [FR]; FERNANDEZ SCOMA ALAIN [FR]


Application No.: US20100256749A1  Published: 07/Oct/2010

Title: Packaging Systems for Percutaneously Deliverable Bioprosthetic Valves

Applicant/Assignee: MEDTRONIC VASCULAR, INC

Application No.: 12/418684   Filing Date: 06/Apr/2009

Abstract:A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.

Priority:

Inventor: TRAN DON [US]; RYAN TIMOTHY [US]; ALLEN JEFFREY [US]; DENTON MELISSA [US]; PODBELSKI ADAM [US]


Application No.: US20100260691A1  Published: 14/Oct/2010

Title: Aqueous compositions containing a hydrophobic material

Applicant/Assignee:

Application No.: 11/803108   Filing Date: 11/May/2007

Abstract:An aqueous composition containing a hydrophobic material, and, more particularly, a water soluble matrix of a water soluble polymer and a water soluble surfactant, in the form of a complex, for stabilizing the hydrophobic material, as a nanoparticulate dispersion or emulsion. A delivery system for delivering bioactive hydrophobic materials as an aqueous nanoparticle dispersion of a water soluble matrix of polymer and a surfactant.

Priority: US2006-496599 Applic. Date: 2006-07-31

Inventor: NARAYANAN KOLAZI S [US]; JON DOMINGO [US]; PATEL JAYANTI [US]; WINKOWSKI KAREN [US]


Application No.: US20100260812A1  Published: 14/Oct/2010

Title: THICKENED FLUID COMPOSITION COMPRISING CHLORINE DIOXIDE

Applicant/Assignee: BASF CORPORATION

Application No.: 12/824830   Filing Date: 28/Jun/2010

Abstract:This invention relates to a stable composition and method of making a thickened fluid composition comprising chlorine dioxide. The stable composition includes a mixture containing a chlorite, an acid source, and a thickener component. At least one of the chlorite, the acid source and the thickener component is in particulate form. In an embodiment, the mixture may be a unitary solid body wherein chlorine dioxide is generated upon interaction with an aqueous medium, such as water. A free halogen source may also be added to the mixture in some cases.

Priority: US2006-340248 Applic. Date: 2006-01-26

Inventor: HRATKO LINDA [US]; CALABRO FRANK JOSEPH [US]; SPERONELLO BARRY K [US]


Application No.: US20100260825A1  Published: 14/Oct/2010

Title: Antifolates for the treatment of cardiovascular, inflammatory, neoplastic, autoimmune and related diseases in sublingual dosage units, film strips, or skin patches

Applicant/Assignee:

Application No.: 12/386015   Filing Date: 13/Apr/2009

Abstract:New metabolism blocked antifolates and their salts are provided along with new indications (coronary heart disease, cardiovascular diseases, stroke and termination of tubal or ectopic pregnancy) and methods (sublingual dosage forms, filmstrips or patches) for their use and delivery. Sublingual dosage forms or trans-dermal patches of metabolically blocked entities of this invention offer superior alternatives to traditional oral dosage forms to achieve greater and predictable therapeutic efficacy, lower toxicity and to overcome drug resistance by virtue of elimination of oxidative deactivation and production of toxic metabolites. Metabolism blocked antifolates bearing a fluorinated benzene ring, a thiophene ring, a pyrrole ring, a furan ring or a 8-deazapteridine ring that are provided in this invention are not previously described. The use of metabolism blocked antifolates to terminate medically complicated pregnancies that are taught herein are new inventions targeted to eliminate drug related toxicity to the host and to enhance therapeutic efficacy.

Priority:

Inventor: NAIR MADHAVAN G [US]


Application No.: US20100260840A1  Published: 14/Oct/2010

Title: Orodispersible pharmaceutical composition of agomelatine

Applicant/Assignee: LES LABORATOIRES SERVIER

Application No.: 12/803250   Filing Date: 22/Jun/2010

Abstract:The invention relates to a solid orodispersible pharmaceutical composition of agomelatine, characterised in that it comprises agomelatine and granules consisting of co-dried lactose and starch.

Priority: FR20020000792 Applic. Date: 2002-01-23; US2004-502593 Applic. Date: 2004-07-23; WO2003FR00197 Applic. Date: 2003-01-22

Inventor: WUTHRICH PATRICK [FR]; ROLLAND HERVE [FR]; JULIEN MARC [FR]; THARRAULT FRANCOIS [FR]


Application No.: US20100261132A1  Published: 14/Oct/2010

Title: System and method for removing surface contamination

Applicant/Assignee:

Application No.: 12/798595   Filing Date: 07/Apr/2010

Abstract:A system and method are provided in which a laminar flow of pressurized gas from a curved slit in a chamber is directed across a surface to propel a laminar flow of a liquid, below the laminar flow gas, across the surface to prevent surface contamination or remove contaminants from the surface. In a particular application, the system and method are employed in a self-cleaning dental mirror tool including a dental mirror attached to a handle, wherein the gas is air, the liquid is water, and the surface is the reflective surface of the dental mirror.

Priority: US20090212213P Applic. Date: 2009-04-08

Inventor: WIDEN RANDY MILES [US]


Application No.: US20100261136A1  Published: 14/Oct/2010

Title: DENTAL RETRACTION COMPOSITION, PRODUCTION THEREOF AND USE OF A POWDER JET DEVICE FOR DENTAL RETRACTION

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/747219   Filing Date: 09/Dec/2008

Abstract:The invention relates to a dental composition comprising a hardenable powder to be used in a process for retraction of dental tissue. The invention also relates to a kit of parts comprising the dental composition comprising a hardenable powder, a hardening agent, optionally a handpiece of a powder jet device, optionally a powder jet device, and optionally retraction caps. In a further aspect, the invention relates to a method for retracting dental tissue comprising the steps of applying a dental composition comprising a hardenable powder with a powder jet device into the sulcus between soft and hard dental tissue, applying a composition comprising a hardening agent either before or after the previous step, leaving the dental composition in the sulcus for a time sufficient to effect retraction of the soft dental tissue and removing the dental composition from the sulcus.

Priority: EP20070122768 Applic. Date: 2007-12-10; WO2008US86013 Applic. Date: 2008-12-09

Inventor: SCHULTE CHRISTOPH [DE]; MAURER ANDREAS R [DE]; KLETTKE THOMAS [DE]; HAMPE RUEDIGER [DE]; HAEBERLEIN INGO R [DE]


Application No.: US20100261143A1  Published: 14/Oct/2010

Title: CURABLE DENTAL RETRACTION COMPOSITION, METHOD OF PRODUCTION AND USE THEREOF

Applicant/Assignee:

Application No.: 12/677831   Filing Date: 09/Sep/2008

Abstract:The invention relates to a curable dental retraction composition comprising alginate and a solvent, with the proviso that essentially no crosslinker in an amount effective to start setting of the curable dental retraction composition is present. The invention also relates to a container containing said composition and to a kit comprising two parts, wherein the first part comprises the curable dental retraction composition of the present invention and the second part comprises a crosslinker being able to start setting of the dental retraction composition.

Priority: EP20070116451 Applic. Date: 2007-09-14; WO2008US75687 Applic. Date: 2008-09-09

Inventor: HAMPE RUEDIGER [DE]; KLETTKE THOMAS [DE]; MAURER ANDREAS R [DE]; SCHULTE CHRISTOPH [DE]


Application No.: US20100261144A1  Published: 14/Oct/2010

Title: Dental Curable Composition

Applicant/Assignee: TOKUYAMA DENTAL CORPORATION

Application No.: 12/742524   Filing Date: 14/Nov/2008

Abstract:[Problems] To provide a chemical polymerization type curable composition which can achieve a very large strength of adhesion even without irradiated with light, and is used in the field of dental therapy. [Means for Solution] A dental curable composition comprising (A) a polymerizable monomer component containing an acidic group-containing polymerizable monomer, (B) water, and (C) a chemical polymerization initiator component comprising a radical-generating species and a reactive species that generates radicals upon reacting with the radical-generating species

wherein, the dental curable composition is stored being divided into a plurality of packages, and is polymerized and cured by mixing together the components contained in the packages

and wherein one package (I) among the packages contains the component (A) and the component (B), and, further, contains polyvalent metal ions in an amount of 0.3 to 10 meq per gram of the polymerizable monomer component (A) contained in the package

and the chemical polymerization initiator (C) is stored being divided into at least two packages so that the radical-generating species and the reactive species do not come in contact with each other.

Priority: JP20070297049 Applic. Date: 2007-11-15; WO2008JP70743 Applic. Date: 2008-11-14

Inventor: FUJINAMI KYOICHI [JP]; DODOMI AYUMI [JP]; MATSUSHIGE KOJI [JP]; OKISHIO KAZUHIKO [JP]


Application No.: US20100261404A1  Published: 14/Oct/2010

Title: Fan Attachment Arrangement

Applicant/Assignee: STILL DREAMING, LLC

Application No.: 12/762690   Filing Date: 19/Apr/2010

Abstract:An attachment arrangement for use in connection with an existing ceiling fan having a plurality of rotatable fan blades. The arrangement includes a connecting arrangement for attaching an object to at least a portion of at least one of the fan blades, such that, as the fan blade rotates, the object rotates via the connecting arrangement.

Priority: US2008-098683 Applic. Date: 2008-04-07; US20070921937P Applic. Date: 2007-04-05

Inventor: ZACHARIAS ANNE [US]; FRAZZINI ROBERT [US]


Application No.: US20100261728A1  Published: 14/Oct/2010

Title: TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS

Applicant/Assignee: AMGEN INC

Application No.: 12/746292   Filing Date: 04/Dec/2008

Abstract:Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Priority: US20070005457P Applic. Date: 2007-12-04; US20070008892P Applic. Date: 2007-12-21; WO2008US13375 Applic. Date: 2008-12-04

Inventor: NORMAN MARK H [US]; BO YUNXIN Y [US]; GORE VIJAY K [US]; HORNE DANIEL [US]; KALLER MATTHEW [US]; MA VU VAN [US]; MONENSCHEIN HOLGER [US]; NGUYEN THOMAS [US]; NISHIMURA NOBUKO [US]; TAMAYO NURIA [US]


Application No.: US20100261967A1  Published: 14/Oct/2010

Title: VIDEO LARYNGOSCOPE SYSTEM AND DEVICES

Applicant/Assignee: VERATHON INC

Application No.: 12/760519   Filing Date: 14/Apr/2010

Abstract:An embodiment encompassing reusable video laryngoscopes that are insertable into transparent or non-transparent disposable sheaths having clear optically clear viewing windows that receive contact with camera lens. The reusable video laryngoscopes are configured to be detachably secured by locking tabs located in the transparent or non-transparent disposable sheaths with complementary shaped posts and ledges of the video laryngoscopes. The video laryngoscopes that are secured into the transparent or non-transparent disposable sheaths may be inserted into the patient's mouth to provide clear camera viewing through the optically clear window ports of the transparent or non-transparent disposable sheaths to allow endotracheal procedures to be undertaken. The transparent or non-transparent disposable sheaths are sterilizable and may be used just once for a given patient. The video laryngoscopes in the form of a baton are detachably removeable from the disposable sheath exposed to a patient.

Priority: US20100319835P Applic. Date: 2010-03-31; US20090169246P Applic. Date: 2009-04-14; US20090261739P Applic. Date: 2009-11-16

Inventor: PACEY JOHN ALLEN [CA]; VISSER MITCHELL [CA]; YAZDI REZA AHMADIAN [CA]; KIM YONGKOOK [CA]


Application No.: US20100263324A1  Published: 21/Oct/2010

Title: BEVERAGE BOTTLING PLANT CONFIGURED TO FILL ALREADY USED, RETURNED, RETURNABLE BEVERAGE BOTTLES WHICH INCLUDES A CLEANING MACHINE, AND A CLEANING MACHINE

Applicant/Assignee:

Application No.: 12/761920   Filing Date: 16/Apr/2010

Abstract:A beverage bottling plant configured to fill already used, returned, returnable beverage bottles which includes a cleaning machine, and a cleaning machine configured to clean used, returnable, cleanable containers in a container filling plant. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. PRG 1.72(b). As stated in 37 C.F.R. PRG 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading "Abstract of the Disclosure." The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Priority: DE200710049724 Applic. Date: 2007-10-16; DE200710054149 Applic. Date: 2007-11-12; WO2008EP08707 Applic. Date: 2008-10-15

Inventor: JENDRICHOWSKI KLAUS [DE]; DITTRICH FALK [DE]; WIEDEMANN ULRICH [DE]; MOLITOR BERND [DE]; HEIN ELMAR [DE]


Application No.: US20100266443A1  Published: 21/Oct/2010

Title: Pd-Ag-Ga DENTAL ALLOYS WITH INTERNAL OXIDATION CHARACTERISTICS

Applicant/Assignee:

Application No.: 12/426490   Filing Date: 20/Apr/2009

Abstract:A Pd-Ag alloy system that utilizes internal oxidation by including a base metal addition of only Ga is provided. The Pd-Ag-Ga alloy is particularly well-suited for use in porcelain-fused-to-metal (PFM) applications because the alloy does not form a dark oxide upon heating. The high oxygen potential of the material ensures the development of a tenacious chemical bond with the porcelain when used in PFM applications. Moreover, the addition of gallium lowers the liquidus temperature of the alloy to improve castability and strengthens the alloy significantly.

Priority:

Inventor: CASCONE PAUL J [US]; PRASAD ARUN [US]


Application No.: US20100266509A1  Published: 21/Oct/2010

Title: HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS

Applicant/Assignee: H. LINDBECK A/S

Application No.: 12/595394   Filing Date: 09/Apr/2008

Abstract:Heteroaryl amide analogues are provided, of Formula (I), wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Priority: US20070910864P Applic. Date: 2007-04-10; WO2008US04563 Applic. Date: 2008-04-09

Inventor: IHLE DAVID C [US]; GUO QIN [US]; HODGETTS KEVIN [US]; YUAN JUN [US]


Application No.: US20100266512A1  Published: 21/Oct/2010

Title: CROSSLINKED HYALURONIC ACID IN EMULSION

Applicant/Assignee: EVONIK GOLDSCHMIDT GMBH

Application No.: 12/809809   Filing Date: 10/Dec/2008

Abstract:The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) providing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof

(b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (VWO) emulsion, wherein the amount of oil phase used is of from 20 to less than 50% by weight based on the sum of oil phase and water

(c) adding a solution comprising a crosslinking agent to the emulsion, whereby the reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads

and (d) optionally working up the dispersion of crosslinked hyaluronic acid microbeads obtained in step (c).

Priority: EP20070150176 Applic. Date: 2007-12-19; US20070015261P Applic. Date: 2007-12-20; WO2008EP67172 Applic. Date: 2008-12-10

Inventor: WENK HANS HENNING [DE]; FARWICK MIKE [DE]; NATTLAND SANDRA [DE]; MACZKIEWITZ URSULA [DE]; MOELHOLM MALLE BIRGITTE [DK]


Application No.: US20100266516A1  Published: 21/Oct/2010

Title: PERSONAL CARE COMPOSITION

Applicant/Assignee: INNOSPEC LIMITED

Application No.: 12/742834   Filing Date: 17/Nov/2008

Abstract:An aqueous shear-thinning personal care composition comprises: (a) at least 3 wt % of a sulfonate compound of general formula (I): where R1 represents a C8-22 alkyl group alkyl group

R2 represents a C1-4 alkyl group

each of R3, R4 and R5 independently represents a hydrogen atom or a C1-4 alkyl group

and M+ represents a sodium or potassium cation

(b) at least 3 wt % of an amphoteric or zwitterionic surfactant

(c) at least 10 wt % of water

and (d) at least 0.5 wt % of an additional component in the form of particles or droplets suspended in the composition. The composition is stable in an aqueous environment and can be formulated with a wide range of additional components.

Priority: GB20070022550 Applic. Date: 2007-11-16; WO2008GB51071 Applic. Date: 2008-11-17

Inventor: COTRELL PHILIP [US]


Application No.: US20100266618A1  Published: 21/Oct/2010

Title: COMPOSITIONS AND METHODS FOR AUGMENTING ACTIVITY OF ONCOLYTIC VIRUSES

Applicant/Assignee: CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE

Application No.: 12/726928   Filing Date: 18/Mar/2010

Abstract:Disclosed are compositions and methods for augmenting activity of oncolytic viruses. Virus activity is augmented by sensitizing cancer or tumour cells through modulation of the Endoplasmic Reticulum (ER) stress response pathway, for instance by introducing into a tumour cell an agent effective to modulate ER stress response and sensitize the tumour cell. The tumour cells are then contacted with an oncolytic virus in an amount effective to reduce viability of the sensitized tumour cell. The oncolytic virus is thereby rendered more effective at lysing or killing the sensitized tumour or cancer cells.

Priority: US20090161297P Applic. Date: 2009-03-18

Inventor: STOJDL DAVID [CA]; MAHONEY DOUGLAS [CA]


Application No.: US20100266668A1  Published: 21/Oct/2010

Title: Manufacturing Dissolvable Dosage Forms

Applicant/Assignee: BATTELLE MEMORIAL INSTITUTE

Application No.: 12/788602   Filing Date: 27/May/2010

Abstract:A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from the outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.

Priority: GB20010007225 Applic. Date: 2001-03-22; GB20010008340 Applic. Date: 2001-04-03; GB20010014674 Applic. Date: 2001-06-15; GB20010016363 Applic. Date: 2001-07-04; GB20010021677 Applic. Date: 2001-09-07; GB20010022399 Applic. Date: 2001-09-17; US2004-472588 Applic. Date: 2004-02-12; WO2002GB01404 Applic. Date: 2002-03-22

Inventor: COFFEE RONALD ALAN [GB]; DAVIES DAVID NEVILLE [GB]; ESSEX-LOPRESTI JOHNATHAN [GB]; SIN KA WAN MARGARET [GB]; BUSBY ANNA [GB]


Application No.: US20100266669A1  Published: 21/Oct/2010

Title: MULTI-ZONE FILMS

Applicant/Assignee: NOVARTIS AG

Application No.: 12/746614   Filing Date: 09/Dec/2008

Abstract:The invention relates to single-layer oral disintegrating films having at least two distinct zones, which comprise nicotine and allow for effective buccal (=oral mucosal) absorption thereof.

Priority: US20070007192P Applic. Date: 2007-12-11; WO2008EP67074 Applic. Date: 2008-12-09

Inventor: MEYER STEPHAN [CH]; SLOMINSKI GREG [US]; FANKHAUSER CHRISTOPHER EDWARD [US]; OUIS NICOLE [CH]


Application No.: US20100266674A1  Published: 21/Oct/2010

Title: L-ODDC PRODRUGS FOR CANCER

Applicant/Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC

Application No.: 12/310576   Filing Date: 30/Aug/2007

Abstract:The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, of which property requires a high and frequent dosage for an intravenous administration. Unlike other nucleoside anti-tumor agents, troxacitabine appears to predominantly enter tumor cells by passive diffusion rather then by using nucleoside transporters, although this may be model dependent. Accordingly, in the present work, a small library of twenty troxacitabine prodrugs has been synthesized using a parallel approach in order to evaluate the relationship between the lipophilicity of the prodrugs and their antitumor activity. Biological evaluation of the prodrugs on two non-small cell lung cancer cell lines (A549 and SW1573) and in pancreatic cell lines clearly showed better antitumor activity than that of troxacitabine, with IC50 values in the nanomolar range.

Priority: US20060842085P Applic. Date: 2006-09-01; WO2007US19016 Applic. Date: 2007-08-30

Inventor: CHU DAVID C K [US]


Application No.: US20100267693A1  Published: 21/Oct/2010

Title: Orodispersible pharmaceutical composition of ivabradine

Applicant/Assignee: LES LABORATOIRES SERVIER

Application No.: 12/803280   Filing Date: 23/Jun/2010

Abstract:The invention relates to a solid orodispersible pharmaceutical composition of ivabradine, characterised in that it comprises ivabradine or a pharmaceutically acceptable salt thereof and granules consisting of co-dried lactose and starch.

Priority: FR20020000791 Applic. Date: 2002-01-23; US2004-502594 Applic. Date: 2004-07-23; WO2003FR00198 Applic. Date: 2003-01-22

Inventor: WUTHRICH PATRICK [FR]; ROLLAND HERVE [FR]; JULIEN MARC [FR]


Application No.: US20100267746A1  Published: 21/Oct/2010

Title: ALIPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS WITH BETA AGONIST ACTIVITY

Applicant/Assignee: PARION SCIENCES, INC

Application No.: 12/304040   Filing Date: 11/Jun/2007

Abstract:The present invention provides sodium channel blockers possessing beta-adrenergic receptor agonist activity.

Priority: US20060812078P Applic. Date: 2006-06-09; WO2007US70857 Applic. Date: 2007-06-11

Inventor: JOHNSON MICHAEL ROSS [US]


Application No.: US20100267759A1  Published: 21/Oct/2010

Title: INHIBITORS OF Akt ACTIVITY

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION

Application No.: 12/526111   Filing Date: 07/Feb/2008

Abstract:Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Priority: US20070888586P Applic. Date: 2007-02-07; WO2008US53269 Applic. Date: 2008-02-07

Inventor: SEEFELD MARK A [US]; ROUSE MEAGAN B [US]; HEERDING DIRK A [US]; PEACE SIMON [GB]; YAMASHITA DENNIS S [US]; MCNULTY KENNETH C [US]


Application No.: US20100267764A1  Published: 21/Oct/2010

Title: 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors

Applicant/Assignee:

Application No.: 11/992836   Filing Date: 09/Nov/2006

Abstract:This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20050001565 Applic. Date: 2005-11-11; US20050736330P Applic. Date: 2005-11-15; WO2006EP68275 Applic. Date: 2006-11-09

Inventor: PETERS DAN [SE]; ERIKSEN BIRGITTE L [DK]; NIELSEN ELSEBET OSTERGAARD [DK]; REDROBE JOHN PAUL [DK]; OLSEN GUNNAR M [DK]


Application No.: US20100267769A1  Published: 21/Oct/2010

Title: Substituted Bicyclocarboxyamide Compounds

Applicant/Assignee: PFIZER, INC. AND RENOVIS INC

Application No.: 12/063159   Filing Date: 09/Nov/2007

Abstract:This invention provides a compound of the formula These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

Priority: US20060866285P Applic. Date: 2006-11-17; US20070943933P Applic. Date: 2007-06-14; US20070983343P Applic. Date: 2007-10-29; WO2007IB03559 Applic. Date: 2007-11-09

Inventor: ANDO KOJI [JP]; CALABRESE ANDREW ANTHONY [GB]; DUNCTON MATTHEW ALEXANDER JAMES [US]; FUTATSUGI KENTARO [JP]; HIRANO MISATO [JP]; NAGAYAMA SATOCHI [JP]


Application No.: US20100267799A1  Published: 21/Oct/2010

Title: Orodispersible pharmaceutical composition of perindopril

Applicant/Assignee: LES LABORATOIRES SERVIER

Application No.: 12/803207   Filing Date: 22/Jun/2010

Abstract:The invention relates to a solid orodispersible pharmaceutical composition of perindopril, characterised in that it comprises perindopril or a pharmaceutically acceptable salt thereof and granules consisting of co-dried lactose and starch.

Priority: FR20020000790 Applic. Date: 2002-01-23; US2004-502479 Applic. Date: 2004-07-23; WO2003FR00200 Applic. Date: 2003-01-22

Inventor: WUTHRICH PATRICK [FR]; ROLLAND HERVE [FR]; JULIEN MARC [FR]


Application No.: US20100267934A1  Published: 21/Oct/2010

Title: STABLE IGG4 ANTIBODIES

Applicant/Assignee: GENMAB A/S

Application No.: 12/602439   Filing Date: 30/May/2008

Abstract:The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

Priority: DK20070000792 Applic. Date: 2007-05-31; DK20070000793 Applic. Date: 2007-05-31; DK20070001002 Applic. Date: 2007-07-06; WO2008DK50129 Applic. Date: 2008-05-30

Inventor: VAN DE WINKEL JAN [NL]; VINK TOM [NL]; SCHUURMAN JANINE [NL]; PARREN PAUL [NL]; AALBERSE ROB [NL]; VAN DER NEUT KOLFSCHOTE MARIJN [NL]


Application No.: US20100268335A1  Published: 21/Oct/2010

Title: MEDICAL DEVICES WITH GALVANIC PARTICULATES

Applicant/Assignee:

Application No.: 12/761601   Filing Date: 16/Apr/2010

Abstract:Implantable medical devices having galvanic particulates are disclosed. The particulates may be coated onto at least part of a surface of the medical device. In addition, the galvanic particulates may be contained in the material used to manufacture the antimicrobial medical devices, or may be embedded into the surface of the medical devices. The present invention also provides novel coating methods and processing methods. The devices may have advantageous characteristics and effects including anti-microbial, anti-inflammatory, and tissue regeneration promoting.

Priority: US2010-731848 Applic. Date: 2010-03-25; US20090163928P Applic. Date: 2009-03-27

Inventor: YANG CHUNLIN [US]; SUN YING [US]; CICHOCKI JR FRANK R [US]; BAR SAUMEN N [US]; HAUSCHILD JAMES E [US]; HERZBERG URI [US]; LI YUFU [US]; MING XINTIAN [US]; KONG WEI [US]; CHANTALAT JEANNETTE [US]; SOUTHALL MICHAEL [US]


Application No.: US20100269367A1  Published: 28/Oct/2010

Title: DEVICE FOR BLOWING GAS ONTO A FACE OF A TRAVELING STRIP OF MATERIAL

Applicant/Assignee:

Application No.: 12/746872   Filing Date: 17/Dec/2008

Abstract:A gas blower device for blowing gas onto a face of a traveling strip of material. The device has at least one hollow box fitted with a plurality of tubular nozzles pointing towards the face in question of the strip of material. On the side facing towards the face in question of the strip of material, the hollow box presents a surface of profile (P) that varies in at least one given direction (D) symmetrically about a midplane (Q) perpendicular to the plane of the strip. The tubular nozzles are fastened via their roots to the varying-profile surface in such a manner that their respective axes are essentially orthogonal to said varying profile at the point in question, said tubular nozzles having respective lengths that are selected so that the outlet orifices lie in a common plane substantially parallel to the plane of the strip.

Priority: FR20070009166 Applic. Date: 2007-12-28; FR20080005843 Applic. Date: 2008-10-22; WO2008FR01761 Applic. Date: 2008-12-17

Inventor: LANGEVIN STEPHANE [FR]; DUBOIS PATRICK [FR]


Application No.: US20100269852A1  Published: 28/Oct/2010

Title: At-home integrated cleaning and disinfection system and method for dental hardware

Applicant/Assignee:

Application No.: 12/803547   Filing Date: 29/Jun/2010

Abstract:An at-home integrated cleaning and disinfection system for dental hardware, for consumer use includes a compact and portable base unit sized for at-home use by a consumer, the base unit including a holding frame and an ultraviolet lamp. The system also includes a cleaning chamber within which dental hardware and a cleaning solution that includes hydrogen peroxide are receivable. The cleaning chamber fits within the holding frame in a manner such that contents of the cleaning chamber are exposed to light emitted by the ultraviolet lamp. A vibration mechanism is positioned so as to cause the cleaning chamber to vibrate while the cleaning chamber is fitted within the holding frame. To clean and disinfect dental hardware, the consumer places dental hardware in the cleaning chamber, fills the cleaning chamber with the cleaning solution, and inserts the cleaning chamber into the holding frame. The vibration mechanism is activated, so as to cause the cleaning chamber to vibrate while the cleaning chamber is fitted within the holding frame, and the ultraviolet lamp is activated, so as to expose contents of the cleaning chamber to light emitted by the ultraviolet lamp.

Priority: US2002-322648 Applic. Date: 2002-12-19

Inventor: PALFY VALERIE [US]; SKOMSKY DON A [US]


Application No.: US20100269861A1  Published: 28/Oct/2010

Title: At-home integrated cleaning and disinfection system and method for dental hardware

Applicant/Assignee:

Application No.: 12/803401   Filing Date: 26/Jun/2010

Abstract:An at-home integrated cleaning and disinfection system for dental hardware, for consumer use includes a compact and portable base unit sized for at-home use by a consumer, the base unit including a holding frame and an ultraviolet lamp. The system also includes a cleaning chamber within which dental hardware and a cleaning solution that includes hydrogen peroxide are receivable. The cleaning chamber fits within the holding frame in a manner such that contents of the cleaning chamber are exposed to light emitted by the ultraviolet lamp. A vibration mechanism is positioned so as to cause the cleaning chamber to vibrate while the cleaning chamber is fitted within the holding frame. To clean and disinfect dental hardware, the consumer places dental hardware in the cleaning chamber, fills the cleaning chamber with the cleaning solution, and inserts the cleaning chamber into the holding frame. The vibration mechanism is activated, so as to cause the cleaning chamber to vibrate while the cleaning chamber is fitted within the holding frame, and the ultraviolet lamp is activated, so as to expose contents of the cleaning chamber to light emitted by the ultraviolet lamp.

Priority: US2002-322648 Applic. Date: 2002-12-19

Inventor: PALFY VALERIE [US]; SKOMSKY DON A [US]


Application No.: US20100270389A1  Published: 28/Oct/2010

Title: Method of dangerous phenomena (mainly, hurricane) and global warning weakening

Applicant/Assignee:

Application No.: 12/590322   Filing Date: 06/Nov/2009

Abstract:The method of gradual weakening of moving hurricane which prevents to gain in maximum energy and some means useful at protection against hurricanes and global warming weakening are offered.

Priority: US2009-386847 Applic. Date: 2009-04-24

Inventor: FELDMAN BORIS [CA]


Application No.: US20100272655A1  Published: 28/Oct/2010

Title: Menthylcarboxamides and Their Use as Cooling Agents

Applicant/Assignee:

Application No.: 12/430585   Filing Date: 27/Apr/2009

Abstract:Described is a new cooling agent represented by Structure I and compositions with known coolers having cooling properties and the application of Structure I in foodstuffs and chewing gum:

Priority:

Inventor: BARDSLEY KATHRYN ANNE [US]; DEWIS MARK L [US]; GRAINGER BRIAN TREVOR [US]; JANCZUK ADAM JAN [US]; KAZIMIERSKI ARKADIUSZ [US]; KRAUT KENNETH J [US]; SONDRUP JOHN L [US]; YANG YING [US]


Application No.: US20100272690A1  Published: 28/Oct/2010

Title: Antimicrobial Compositions and Related Methods of Use

Applicant/Assignee:

Application No.: 12/768529   Filing Date: 27/Apr/2010

Abstract:Antimicrobial compositions comprising one or more compound components generally recognized as safe for human consumption, and related methods of use, such compositions and methods as can be employed in a wide range of agricultural, industrial, building, pharmaceutical and/or personal care products and applications.

Priority: US20090214752P Applic. Date: 2009-04-27; US20090257319P Applic. Date: 2009-11-02; US20100315611P Applic. Date: 2010-03-19

Inventor: GANDHI NIRANJAN RAMANLAL [US]; PALMER SKEBBA VICTORIA [US]; STROBEL GARY A [US]


Application No.: US20100272764A1  Published: 28/Oct/2010

Title: MICROENCAPSULATED COMPOSITIONS AND METHODS FOR TISSUE MINERALIZATION

Applicant/Assignee:

Application No.: 12/768696   Filing Date: 27/Apr/2010

Abstract:The present invention is directed to compositions, products and methods useful for bone and tooth mineralization. The compositions comprise polymer microcapsules containing aqueous salt solutions. The shells of the microcapsules can be semi-permeable or impermeable. Solutions of calcium, fluoride and phosphate salts are particularly useful in the compositions of the invention. The microcapsules are preferably prepared by surfactant free inverse emulsion interfacial polymerization. Bone products include cements, scaffolds and bioactive glass. Dental products include pastes, gels, rinses and many other dental materials.

Priority: US20090172939P Applic. Date: 2009-04-27

Inventor: LATTA MARK A [US]; GROSS STEPHEN M [US]; MCHALE WILLIAM A [US]


Application No.: US20100273380A1  Published: 28/Oct/2010

Title: SELECTIVELY PERMEABLE PROTECTIVE STRUCTURE AND ARTICLES THEREFROM

Applicant/Assignee: E.I. DU PONT DE NEMOURS AND COMPANY

Application No.: 12/762706   Filing Date: 19/Apr/2010

Abstract:A selectively permeable protective structure and a method for limiting damage to the article due to corrosion or mold growth, comprising wrapping or covering the article in the selectively permeable protective structure. The selectively permeable structure comprises a membrane having a moisture vapor permeation value of at least 200 g-mil/m2/24 h and barrier to liquid water, and optionally a supporting substrate.

Priority: US20090172036P Applic. Date: 2009-04-23; US20090237789P Applic. Date: 2009-08-28

Inventor: CHEN JOHN CHU [US]; VISIOLI DONNA LYNN [US]


Application No.: US20100273910A1  Published: 28/Oct/2010

Title: POLYNITRONES AND USE THEREOF FOR CROSS-LINKING UNSATURATED POLYMERS

Applicant/Assignee: HEINRICH-HEINE-UNIVERSITAET

Application No.: 12/747582   Filing Date: 10/Dec/2008

Abstract:The present invention relates to polyfunctional nitrones (optionally in the form of nitrone-terminated polymers) and to their use as crosslinking agents and matting agents, preferably for producing stable molding compounds, knifing fillers, and use thereof in inks, coatings, and adhesives. Low crosslinking temperatures characterize the invention. Through the use of polyfunctional nitrones it is possible for all unsaturated polymers to be cured, solidified and/or structured at low temperatures, preferably without use of a catalyst. Depending on the amount of nitrone-terminated polymers and/or low molecular mass polyfunctional nitrone used it is possible to exert a strong influence over the optical and the mechanical properties of the coated surfaces. By optical properties are meant, among others, the gloss of the coating systems and the surface structuring, e.g., the matt effect.

Priority: DE200710059733 Applic. Date: 2007-12-12; WO2008EP10487 Applic. Date: 2008-12-10

Inventor: CINAR HAKAN [DE]; RITTER HELMUT [DE]


Application No.: US20100274073A1  Published: 28/Oct/2010

Title: Methods and Devices for Predicting Ovulation and Optimum Insemination Time of Animals

Applicant/Assignee:

Application No.: 12/376305   Filing Date: 06/Aug/2007

Abstract:Manual techniques for monitoring animal ovulation cycle have been used commercially to determine the best time to breed animals. Techniques using heat as an indicator for ovulation do not always correspond to ovulation. The present invention provides methods, apparatus, and kits for monitoring and predicting ovulation using an automated hand-held device, incorporating a computer and probe for detecting physical changes in the animal body fluid. Changes in electrolyte levels are detected as alterations in resistance which corresponds to specific intervals in the ovulation cycle. The present invention provides a rapid, low cost means for monitoring mammalian ovulation cycles and a tool for use in artificial insemination, especially in assessing large populations of animals.

Priority: US20060835799P Applic. Date: 2006-08-04; WO2007US17452 Applic. Date: 2007-08-06

Inventor: REGAS PHILIP GEORGE CHELF [US]


Application No.: US20100275394A1  Published: 04/Nov/2010

Title: Oral Care Implement With Cavitation System

Applicant/Assignee:

Application No.: 12/159279   Filing Date: 04/Jun/2008

Abstract:An oral care implement generates cavitation within the oral cavity. One or more cavitation cleaning elements may be located in the head area of the oral care implement. The cavitation cleaning element vibrates at a frequency that produces cavitation of fluids within the oral cavity. The oral care implement may include an elastomeric cavitation cleaning element. A cleaning element may be configured to vibratory release an oral care substance from a container

and a body for gripping the implement.

Priority: WO2008US65704 Applic. Date: 2008-06-04

Inventor: KEMP JAMES HERBERT [US]; WILLIAMS MALCOLM [US]


Application No.: US20100275757A1  Published: 04/Nov/2010

Title: CLAMP

Applicant/Assignee:

Application No.: 12/671511   Filing Date: 31/Jul/2008

Abstract:A clamp (1d) comprises a clamp bracket (3f) and an elastic cord (5) threaded through a pair of apertures (7b, 9b) in the clamp bracket (3f). The clamp bracket (3f) further comprises a pair of keyhole-shaped holes (19f) for receiving an end portion (31) of the cord (5). The shape of the keyhole-shaped holes (19f) is such that the cord (5) is insertable into part of the hole (19f) when the cord is tensioned and the cord (5) is gripped by inner walls of an adjoining part of the hole (19f) when the cord is untensioned.

Priority: GB20070014962 Applic. Date: 2007-08-01; GB20080002017 Applic. Date: 2008-02-04; GB20080002222 Applic. Date: 2008-02-06; WO2008GB02615 Applic. Date: 2008-07-31

Inventor: HALLET TREVOR [GB]; JAEGER MICHAEL [GB]


Application No.: US20100275938A1  Published: 04/Nov/2010

Title: Device, Method and Compositions For Reducing the Incidence of Tobacco Smoking

Applicant/Assignee:

Application No.: 12/838196   Filing Date: 16/Jul/2010

Abstract:A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Priority: US2005-240852 Applic. Date: 2005-09-30; US20040614883P Applic. Date: 2004-09-30

Inventor: ROTH BRETT J [US]; CLAYTON TERRILL S [US]


Application No.: US20100278692A1  Published: 04/Nov/2010

Title: NOVEL DRUG CHECKING CUP FOR IN FIELD DRUG TESTING

Applicant/Assignee:

Application No.: 12/432008   Filing Date: 29/Apr/2009

Abstract:A drug checking cup includes a special container constructed of a transparent plastic with an oval truncated top member and an oval truncated bottom member connected by a continuous wall to form a container for the cup, with the continuous wall having a flat portion, plus a circular mouth formed in the top member and a lid operable to close the mouth along with a flat cassette containing at least one drug testing strip placed in the cup through the mouth and retainer means in the cup securing the cassette in the cup at an angle to the inner surface of said flat portion of the continuous wall and in close proximity thereto whereby images on the testing strip in the cassette can be viewed, photocopied and scanned through said flat portion of the wall without distortion from the presence of the specimen in the cup in the space between the cassette and the flat portion of the continuous wall.

Priority:

Inventor: CHEN JAINFENG [US]


Application No.: US20100278756A1  Published: 04/Nov/2010

Title: Peptides having activities of insulin like growth factor-1 and their uses

Applicant/Assignee: CAREGEN CO., LTD

Application No.: 12/659546   Filing Date: 12/Mar/2010

Abstract:The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

Priority: KR20060021099 Applic. Date: 2006-03-06; US2008-224788 Applic. Date: 2008-09-05; WO2007KR01086 Applic. Date: 2007-03-06

Inventor: CHUNG YONG JI [KR]; KIM YOUNG DEUG [KR]; KIM EUN MI [KR]


Application No.: US20100278826A1  Published: 04/Nov/2010

Title: Designer Ubiquitin Ligases For Regulation Of Intracellular Pathogenic Proteins

Applicant/Assignee:

Application No.: 12/481889   Filing Date: 10/Jun/2009

Abstract:The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes an antibody fragment that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes

and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.

Priority: US20080060340P Applic. Date: 2008-06-10

Inventor: SHOEMAKER CHARLES B [US]; OYLER GEORGE A [US]; TZIPORI SAUL [US]


Application No.: US20100278901A1  Published: 04/Nov/2010

Title: COMPOSITIONS AND METHODS OF MAKING RAPIDLY DISSOLVING IONICALLY MASKED FORMULATIONS

Applicant/Assignee: NEOS THERAPEUTICS, LP

Application No.: 12/717251   Filing Date: 04/Mar/2010

Abstract:The present invention includes compositions and methods for reduce the taste of the drug in the drug resin complex. The composition may include one or more drug-resin complexes and a highly compressible, free-flowing pharmaceutical excipient. The resin is present in an amount effective to reduce the taste of the drug in the drug resin complex relative to an otherwise identical pharmaceutical composition without the resin

and wherein the highly compressible, free-flowing pharmaceutical excipient causes release of the drug-resin complex in the mouth.

Priority: US2005-255555 Applic. Date: 2005-10-21

Inventor: TENGLER MARK [US]; MCMAHEN RUSSELL LEE [US]


Application No.: US20100278916A1  Published: 04/Nov/2010

Title: TOPICAL APPLICATION AND FORMULATION OF ERYTHROPOIETIN FOR SKIN WOUND HEALING

Applicant/Assignee: HERAEUS KULZER GMBH

Application No.: 12/810711   Filing Date: 20/Dec/2008

Abstract:The invention relates to the use of erythropoietin (EPO), in particular EPO in a polymer-based pharmaceutical preparation which stabilises the active compound, for the treatment of traumatised skin, in particular for wound healing in the case of mechanical or pathological injuries or in the case of burns. In particular, the invention also relates to specific viscous or gelatinous formulations, in particular based on polysaccharides, preferably cellulose derivatives, which comprise EPO and are capable of stabilising the latter and releasing it slowly and uniformly to the wound.

Priority: EP20070025167 Applic. Date: 2007-12-28; WO2008EP10978 Applic. Date: 2008-12-20

Inventor: BADER AUGUSTINUS [DE]


Application No.: US20100278998A1  Published: 04/Nov/2010

Title: ONE-COMPONENT DENTAL ADHESIVE COMPOSITIONS AND METHOD OF USE

Applicant/Assignee: KERR CORPORATION

Application No.: 12/835422   Filing Date: 13/Jul/2010

Abstract:A one-component self-etching self-priming dental adhesive composition is disclosed. The composition comprises glycerol phosphate di(meth)acrylate monomer, at least one mono-functional polymerizable monomer having just one ethylenically unsaturated group, at least one multi-functional polymerizable monomer having at least two ethylenically unsaturated groups, at least one aprotic solvent, at least one protic solvent, and at least one polymerization initiator.

Priority: US2005-321489 Applic. Date: 2005-12-29

Inventor: CHEN XIANGXU [US]; QIAN XUEJUN [US]


Application No.: US20100279243A1  Published: 04/Nov/2010

Title: METHODS AND APPARATUS FOR APPLYING DENTAL SEALANT TO AN ORTHODONTIC PATIENT'S TEETH

Applicant/Assignee:

Application No.: 12/743634   Filing Date: 20/Nov/2008

Abstract:A set of orthodontic appliances is releasably connected to wall portions of a bonding tray that is used in an indirect bonding procedure. A quantity of dental sealant is applied to wall portions of the tray, and is subsequently transferred to enamel surfaces of the patient s teeth when the bonding tray is placed in position over one of the patient s dental arches. The dental sealant tends to reduce the formation of plaque in regions of the patient s tooth surfaces adjacent the orthodontic appliances.

Priority: US20070991041P Applic. Date: 2007-11-29; WO2008US84127 Applic. Date: 2008-11-20

Inventor: CINADER JR DAVID K [US]; MAH JAMES K [US]


Application No.: US20100280145A1  Published: 04/Nov/2010

Title: Ceramic Composite

Applicant/Assignee: TUNDRA COMPOSITES, LLC

Application No.: 12/769500   Filing Date: 28/Apr/2010

Abstract:The invention relates to a ceramic particulate and polymer composite having enhanced viscoelastic and rheological properties.

Priority: US20090173791P Applic. Date: 2009-04-29

Inventor: HEIKKILA KURT E [US]; WILLIAMS RODNEY K [US]; KROLL JOHN S [US]


Application No.: US20100280164A1  Published: 04/Nov/2010

Title: Inorganic Composite

Applicant/Assignee: TUNDRA COMPOSITES, LLC

Application No.: 12/769509   Filing Date: 28/Apr/2010

Abstract:The invention relates to a nonmetallic inorganic or mineral particulate polymer composite having enhanced viscoelastic and rheological properties.

Priority: US20090173791P Applic. Date: 2009-04-29

Inventor: HEIKKILA KURT E [US]; WILLIAMS RODNEY K [US]; KROLL JOHN S [US]


Application No.: US20100280493A1  Published: 04/Nov/2010

Title: Methods and Systems for Treating Injured Cardiac Tissue

Applicant/Assignee:

Application No.: 11/619575   Filing Date: 03/Jan/2007

Abstract:Methods and systems are disclosed for treating cardiac tissue by delivering a platelet composition which induces neovascularization in the cardiac tissue followed by a cell preparation which induces regeneration in the re-vascularized tissue. The platelet composition can additionally contain structural materials and/or bioactive agents.

Priority: US2006-426211 Applic. Date: 2006-06-23; US2006-426219 Applic. Date: 2006-06-23; US20050693749P Applic. Date: 2005-06-23; US20060743686P Applic. Date: 2006-03-23

Inventor: NAYAK ASHA [US]


Application No.: US20100280582A1  Published: 04/Nov/2010

Title: DEVICE, SYSTEM AND METHOD OF REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS

Applicant/Assignee: ZELTIQ AESTHETICS, INC

Application No.: 12/772040   Filing Date: 30/Apr/2010

Abstract:Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.

Priority: US20090174487P Applic. Date: 2009-04-30

Inventor: BAKER MARK [US]; COAKLEY JOSEPH [US]; MARTENS PAUL WILLIAM [US]; OLLERDESSEN ALBERT L [US]; PENNYBACKER WILLIAM P [US]; ROSEN JESSE N [US]; YEE PETER [US]; ALLISON JOHN W [US]; WEBER BRYAN [US]


Application No.: US20100280793A1  Published: 04/Nov/2010

Title: METHOD AND DEVICE FOR MEASURING THE EFFICACY OF PLAQUE REMOVAL

Applicant/Assignee:

Application No.: 12/832652   Filing Date: 08/Jul/2010

Abstract:A method for measuring the efficacy of a dental care product with respect to plaque removal on the teeth of a volunteer, comprising the steps: a) requesting selection of a plaque index system on a display device

b) requesting selection of a model tooth to be examined and display of the selected model tooth on the display device

c) requesting input of the plaque data on the model tooth displayed on the display device according to the selected plaque index. d) repeating steps b) and c) for a predetermined number of teeth

and e) determining the percentage amount of plaque for each tooth by calculating the ratio of the area covered with plaque to the tooth surface, wherein the area covered with plaque is calculated according to the selected plaque index.

Priority: EP20080021327 Applic. Date: 2008-12-09; WO2009IB55471 Applic. Date: 2009-12-02

Inventor: WILHELM JOACHIM [DE]; WALDMEIER MICHAEL [DE]; SCHAMBERG STEFAN [DE]; TIMM HANS [DE]; TREBITZ BERND [DE]


Application No.: US20100281770A1  Published: 11/Nov/2010

Title: METHOD AND APPARATUS FOR STRIPPING MATERIAL FROM A LINE

Applicant/Assignee: HONEY-POT HOLDINGS LIMITED

Application No.: 12/682245   Filing Date: 17/Oct/2008

Abstract:A method and apparatus (100) for stripping irregular material (2) from a line (1) during relative movement between the apparatus (100) and line (1). The apparatus (100) includes a line guide (200), material guide (210) and stripping mechanism (101). The line (1) passes through the line guide (200). The material guide (210) is configured to guide, constrict, compact and/or re-orientate the irregular material (2) into engagement with the stripping mechanism (101). The stripping mechanism (101) has stripping elements (102) movable with respect to the line guide (200) and line (1) to strip the material (2) from the line (1). The method includes stripping material (2) from a line (1) extending between two end supports (4) and being releasably attached to intermediate supports (3). The material (2) is stripped by causing relative movement between a guide (100) and the line (1) after the line (1) is detached and moved away from the intermediate supports (3).

Priority: NZ20070562703 Applic. Date: 2007-10-19; WO2008NZ00270 Applic. Date: 2008-10-17

Inventor: GEORGE NIGEL HAMISH [NZ]; WICKHAM MARCUS JAMES [NZ]; LOVE GARRY TREVOR [NZ]; LOVE ALBERT ARNOLD [NZ]


Application No.: US20100282246A1  Published: 11/Nov/2010

Title: NASAL DELIVERY

Applicant/Assignee: OPTINOSE AS

Application No.: 12/594361   Filing Date: 07/Apr/2008

Abstract:A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece (17) for fitting to a nostril of a subject, wherein the nosepiece (17) comprises a tip element (25) which includes a delivery aperture (26) from which substance is in use delivered into the nasal cavity, and the tip element (25) is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece (17), with the delivery aperture (28) extending both laterally across the tip element (25) and along a longitudinal extent of the tip element (25)

a nozzle (35) through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece (17), to the respective nasal cavity

and a delivery unit (37) for delivering substance through the nozzle (35) of the nosepiece (17).

Priority: GB20070006863 Applic. Date: 2007-04-05; WO2008GB01217 Applic. Date: 2008-04-07

Inventor: DJUPESLAND PER GISLE [NO]; SHELDRAKE COLIN DAVID [GB]


Application No.: US20100282263A1  Published: 11/Nov/2010

Title: PORTABLE INTAKE AIR STERILIZING APPARATUS

Applicant/Assignee: TAIKO PHARMACEUTICAL CO., LTD

Application No.: 12/738058   Filing Date: 02/Oct/2008

Abstract:There is provided a portable intake air sterilizing apparatus which allows prevention of a worker's infection with virus/bacteria and which allows, at the same time, the worker to work comfortably. The apparatus includes a cover member C for covering one or both of the nose and the mouth, an air intake portion K for the inner space of the cover member C, and a chlorine dioxide slow-release portion J capable of releasing chlorine dioxide gas into an intake air in association with introduction of this intake air from the air intake portion K.

Priority: JP20070267965 Applic. Date: 2007-10-15; WO2008JP67917 Applic. Date: 2008-10-02

Inventor: ASADA SHIGEO [JP]; SHIBATA TAKASHI [JP]


Application No.: US20100282315A1  Published: 11/Nov/2010

Title: LOW CONCENTRATING PHOTOVOLTAIC THERMAL SOLAR COLLECTOR

Applicant/Assignee:

Application No.: 12/437068   Filing Date: 07/May/2009

Abstract:A low concentrating solar collector comprising: at least one elongated cross-sectionally V-shape beam, a first and second sunray light reflecting surfaces integral to the respective interior faces of the V-shape beam side legs, at least one of a photovoltaic cell and of a thermal collector member carried by the beam web, the selected photovoltaic cell member and thermal collector member having exposed surfaces accessible to sunrays crossing the V-beam mouth and striking and deflected by the beam side walls light reflecting surfaces toward the beam web. The beam side walls are of such size and composition as to be able to constitute heat sink for optimizing thermal management of the solar collector.

Priority:

Inventor: GILBERT RAYMOND [CA]


Application No.: US20100282624A1  Published: 11/Nov/2010

Title: SECURITY CAPSULE WITH BREAKABLE RESERVOIR AND CUTTER

Applicant/Assignee: BORMIOLI ROCCO & FIGLIO S.P.A

Application No.: 12/811273   Filing Date: 10/Sep/2008

Abstract:A safety capsule (1) with a reservoir (2) is breakable by means of a cutter (3), and is usable for single-dose or multi-dose containers. The capsule comprises a cap (4) associated to a mouth (7) of the container, in which the reservoir (2) destined to contain the cutter (3) is afforded, and a closing cover (5), provided with a security strip (6)

first connecting means (4a, 6a, 4e, 5d) prevent, with the security strip (6) unbroken, an axially-directed translation between the cover (5) and the cap (4)

second connecting means (4b, 5b), when the capsule is unopened, render the cover (5) and the cap (4) solid in rotation in a screwing-on direction of the cap (4) on the mouth (2) and free in rotation in an unscrewing direction of the cap (4) on the mouth (2)

third connecting means (4c, 5c) render the cover (5) and the cap (4) solid in rotation when the cover is in the lower position (B) thereof.

Priority: WO2008IT00582 Applic. Date: 2008-09-10

Inventor: PAGANUZZI VALERIO [IT]


Application No.: US20100284191A1  Published: 11/Nov/2010

Title: LIGHTING BODY

Applicant/Assignee: IMC EST

Application No.: 12/678600   Filing Date: 17/Sep/2008

Abstract:The invention relates to a special headlight lens and a special lamp provided with said headlight lens having low energy consumption, low diffused light loss and a rectangular light field. The invention further relates to the range of possible applications for the professional lighting of large areas or as component of beamers, projectors, and medical luminaires.

Priority: EP20070018186 Applic. Date: 2007-09-17; US20070974622P Applic. Date: 2007-09-24; WO2008EP07770 Applic. Date: 2008-09-17

Inventor: DUCHOWICZ DANIEL [CH]


Application No.: US20100284616A1  Published: 11/Nov/2010

Title: TEETH LOCATING AND WHITENING IN A DIGITAL IMAGE

Applicant/Assignee:

Application No.: 12/810912   Filing Date: 01/Feb/2008

Abstract:A method for changing the color of teeth in a digital image is disclosed herein. An embodiment of the method comprises locating the position of a mouth region in the digital image

defining a correction zone associated with the mouth region

calculating the probability that at least one pixel in the correction zone represents a tooth

and changing the color of the at least one pixel by an amount that is proportional to the probability.

Priority: WO2008US52838 Applic. Date: 2008-02-01

Inventor: DALTON DAN [US]; OGG MICHELLE [US]


Application No.: US20100284913A1  Published: 11/Nov/2010

Title: Methods and compositions for studying, imaging, and treating pain

Applicant/Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO

Application No.: 12/800053   Filing Date: 07/May/2010

Abstract:Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analogue binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject. In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analogue compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.

Priority: US20090176172P Applic. Date: 2009-05-07

Inventor: BOIS JUSTIN DU [US]; MULCAHY JOHN [US]; ANDRESEN BRIAN [US]; YEOMANS DAVID C [US]; BISWAL SANDIP [US]


Application No.: US20100284931A1  Published: 11/Nov/2010

Title: FLUORESCENT PHOSPHOLIPID ETHER COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/463998   Filing Date: 11/May/2009

Abstract:The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and their use in a variety of diagnostic applications, including fluorescence imaging of tumors. A preferred compound of the present invention has the following structural formula:

Priority:

Inventor: PINCHUK ANATOLY [US]; WEICHERT JAMEY P [US]; LONGINO MARC [US]; KANDELA IRAWATI [US]; CLARKE WILLIAM R [US]


Application No.: US20100284943A1  Published: 11/Nov/2010

Title: Active Formulations Based on Plant Extracts

Applicant/Assignee:

Application No.: 12/810654   Filing Date: 25/Jun/2010

Abstract:The present invention provide formulations with antibacterial and biofilm removing actions comprising plant extracts, comprising at least one plant oil wherein the plant is selected from the group comprising the genus Protium, Guatteria, Cyperus in a suitable vehicle.

Priority: WO2007BR00375 Applic. Date: 2007-12-28

Inventor: FROTA CORREA RENILTO [BR]; PAOLUCCI SALES JANAINA [BR]; DE ARAUJO BEZERRA JAQUELINE [BR]; DE MOURA RABELO DIEGO [BR]; DE OLIVEIRA LUIZ ANTONIO [BR]; BELEM PINHEIRO MARIA LUCIA [BR]; DA SILVA SILO SOARES [BR]; ASTOLFI FILHO SPARTACO [BR]


Application No.: US20100284947A1  Published: 11/Nov/2010

Title: Food Product to Prevent Tooth Decay

Applicant/Assignee:

Application No.: 12/775292   Filing Date: 06/May/2010

Abstract:An anti cavity bioconsumable liquid which may be provided in the liquid form or frozen form is disclosed herein. The liquid may include up to about 5 wt. % xylitol for the purposes of mitigating tooth decay when the bioconsumable liquid is ingested or consumed by a person. Moreover, the bioconsumable liquid may include up to about 5 wt. % of dextrose but never more than the wt. % of xylitol for the purposes of sweetening the bioconsumable liquid to retain an acceptable flavor profile. An infant, child or adult may consume the bioconsumable liquid during which the xylitol acts to mitigate tooth decay. The bioconsumable liquid may also be frozen in an ice pop configuration and consumed by a child or an adult. The ice pop retains an acceptable flavor profile and also mitigates tooth decay.

Priority: US20090176592P Applic. Date: 2009-05-08

Inventor: BRISLEY MARK WILLIAM [US]


Application No.: US20100285056A1  Published: 11/Nov/2010

Title: Baculovirus-Based Vaccines

Applicant/Assignee: KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP KR BIOTECH CO., LTD

Application No.: 12/812053   Filing Date: 09/Jan/2009

Abstract:The present invention relates to a recombinant baculovirus comprising: (a) a nucleotide sequence encoding a foreign virus envelope protein

(b) a first promoter operatively linked to the envelope-encoding nucleotide sequence

(c) a nucleotide sequence encoding an antigen protein

and (d) a second promoter operatively linked to the antigen-encoding nucleotide sequence

and a vaccine composition using the same. The recombinant baculovirus of the present invention has an excellent efficacy on both humoral and cellular immune responses against a specific antigen (e.g., HPV L1), enabling to function as a more efficient DNA vaccine.

Priority: KR20080002733 Applic. Date: 2008-01-09; WO2009KR00136 Applic. Date: 2009-01-09

Inventor: KIM YOUNG-BONG [KR]; LEE HEE JUNG [KR]; PARK NURI [KR]; OH YU-KYOUNG [KR]


Application No.: US20100285151A1  Published: 11/Nov/2010

Title: METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH INFECTION AND/OR INFLAMMATION

Applicant/Assignee: PURICORE, INC

Application No.: 12/523507   Filing Date: 16/Jan/2008

Abstract:The present invention provides methods and compositions for treating and preventing conditions characterized by infection and/or inflammation, especially of the eyes, ears, nose, and/or throat. The methods of the invention involve administering hypohalous acid to the patient, such as in the form of a composition described herein.

Priority: US20070885122P Applic. Date: 2007-01-16; WO2008US51208 Applic. Date: 2008-01-16

Inventor: GOLDAN KEITH [US]; SAMPSON CLAIRE [US]


Application No.: US20100285180A1  Published: 11/Nov/2010

Title: DONENESS INDICATOR FOR HEAT-IN PACKAGING AND METHOD OF MAKING SAME

Applicant/Assignee: GENERAL MILLS, INC

Application No.: 12/773210   Filing Date: 04/May/2010

Abstract:A heat-in package with doneness indicator for heating applications, such as microwave heating of foods or sterilization applications. The doneness indicator comprises indicia printed with thermochromatic ink on the heat-in packaging. The doneness indicator can be sealed from front to back on the heat-in packaging in such a way that the heat transfer to the sealed area is controlled so that the contents contained within the heat-in packaging has adequate time to heat before a color change or other visual transformation is observed in the doneness indicator. Furthermore, the sealed area containing the thermochromatic ink is not in direct contact with the contents within the packaging. The ink changes due to heat conduction through the film. A venting system can further be incorporated to prevent excessive pressure build-up within the packaging.

Priority: US20090176397P Applic. Date: 2009-05-07

Inventor: GAYLOR ANTHONY [US]; HOESE THOMAS C [US]; REPPE TIM [US]; STRAUS STEVE [US]


Application No.: US20100285424A1  Published: 11/Nov/2010

Title: DENTAL APPLICATOR DEVICE

Applicant/Assignee:

Application No.: 12/664207   Filing Date: 28/Jan/2009

Abstract:A dental applicator device is disclosed. Generally, the dental applicator device includes a trough comprising a first wall, a second wall, and a floor, wherein at least one of the first wall, second wall, and floor comprises a contact surface, wherein at least a portion of the contact surface comprises a reticulated foam material. Methods of applying a dental agent to a target surface of a subject's dentition are also disclosed. Generally, the methods include providing a dental applicator device that includes a trough having a first wall, a second wall, and a floor, wherein at least one of the first wall, second wall, and floor comprises a contact surface, wherein at least a portion of the contact surface comprises a reticulated foam material, and a dental agent disposed in at least a portion of the trough

applying the dental applicator device to at least a portion of the subject's dentition for a time effective to transfer an effective amount of the dental agent to at least a portion of the target surface

and removing the dental applicator device.

Priority: US20080024740P Applic. Date: 2008-01-30; WO2009US32211 Applic. Date: 2009-01-28

Inventor: BURGIO PAUL A [US]; DUNSHEE WAYNE K [US]; JOHNSTON RAYMOND P [US]


Application No.: US20100286134A1  Published: 11/Nov/2010

Title: NOVEL PHENOXAZIN-3-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/677053   Filing Date: 08/Sep/2008

Abstract:This invention relates to novel phenoxazin-3-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20070001304 Applic. Date: 2007-09-10; US20070971273P Applic. Date: 2007-09-11; WO2008EP61835 Applic. Date: 2008-09-08

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100286193A1  Published: 11/Nov/2010

Title: Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors

Applicant/Assignee:

Application No.: 11/990015   Filing Date: 30/Aug/2006

Abstract:This invention relates to novel azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20050001218 Applic. Date: 2005-09-01; US20050713367P Applic. Date: 2005-09-02; WO2006EP65804 Applic. Date: 2006-08-30

Inventor: PETERS DAN [DK]; DAHL BJARNE H [DK]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100286195A1  Published: 11/Nov/2010

Title: NOVEL BENZOOXAZOL-AND BENZOOXATHIOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/677077   Filing Date: 08/Sep/2008

Abstract:This invention relates to novel benzooxazol- and benzooxathiol-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20070001303 Applic. Date: 2007-09-10; US20070971274P Applic. Date: 2007-09-11; WO2008EP61834 Applic. Date: 2008-09-08

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100291004A1  Published: 18/Nov/2010

Title: COMPOSITIONS FOR DELIVERING HYPNOTIC AGENTS ACROSS THE ORAL MUCOSA AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 12/722398   Filing Date: 11/Mar/2010

Abstract:The present invention provides novel compositions for the delivery of a hypnotic agent across the oral mucosa. In particular, the buffer system in the compositions of the present invention raises the pH of saliva to a pH greater than about 7.8, thereby facilitating the substantially complete conversion of the hypnotic agent from its ionized to its un-ionized form. As a result, the dose of hypnotic agent is rapidly and efficiently absorbed by the oral mucosa with surprisingly low inter-subject variability. Furthermore, delivery of the hypnotic agent across the oral mucosa advantageously bypasses hepatic first pass metabolism of the drug and avoids enzymatic degradation of the drug within the gastrointestinal tract. Methods for using the compositions of the present invention for treating sleep disorders such as insomnia are also provided.

Priority: US2007-833323 Applic. Date: 2007-08-03; US2005-060641 Applic. Date: 2005-02-16; US20040598629P Applic. Date: 2004-08-03; US20040608957P Applic. Date: 2004-02-17

Inventor: SINGH NIKHILESH N [US]


Application No.: US20100291006A1  Published: 18/Nov/2010

Title: Natural Preservatives and Antimicrobial Agents

Applicant/Assignee: HORIZON SCIENCE PTY LTD

Application No.: 12/681240   Filing Date: 03/Oct/2008

Abstract:The invention relates to preservatives and antimicrobial agents including extracts derived from sugar cane.

Priority: AU20070905459 Applic. Date: 2007-10-05; WO2008AU01458 Applic. Date: 2008-10-03

Inventor: KANNAR DAVID [AU]; KITCHEN BARRY JAMES [AU]


Application No.: US20100291080A1  Published: 18/Nov/2010

Title: COMPOSITIONS AND METHODS FOR TISSUE REPAIR

Applicant/Assignee:

Application No.: 12/601522   Filing Date: 30/May/2008

Abstract:The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.

Priority: US20070941051P Applic. Date: 2007-05-31; WO2008US65303 Applic. Date: 2008-05-30

Inventor: LEE RANDALL J [US]; MIHARDJA SHIRLEY [US]; HUANG MANLEY [US]; LARRICK JAMES W [US]


Application No.: US20100291162A1  Published: 18/Nov/2010

Title: ORAL COMPOSITIONS PROVIDING ENHANCED TOOTH STAIN REMOVAL

Applicant/Assignee:

Application No.: 12/301946   Filing Date: 25/May/2007

Abstract:This invention generally relates to oral compositions (e.g., a confection or chewing gum product such as a compressed chewing gum) effective for removal of stains from a tooth surface. In particular, this invention relates to oral compositions including a coated or an encapsulated protease enzyme to provide an oral composition effective for tooth stain removal.

Priority: US20060803174P Applic. Date: 2006-05-25; WO2007US69718 Applic. Date: 2007-05-25

Inventor: HAAS MICHAEL S [US]


Application No.: US20100291163A1  Published: 18/Nov/2010

Title: ORAL CARE COMPOSITION COMPRISING NANOPARTICULATE TITANIUM DIOXIDE

Applicant/Assignee:

Application No.: 12/438070   Filing Date: 22/Aug/2007

Abstract:The present invention relates to an oral care composition comprising nanoparticulate titanium dioxide, optionally together with a source of fluoride ions, for combating dental erosion and/or tooth wear. In addition such compositions may also have benefit in tooth whitening. When a source of fluoride ions is present such compositions are also of benefit in combating dental caries.

Priority: GB20060016823 Applic. Date: 2006-08-24; GB20070006780 Applic. Date: 2007-04-05; WO2007EP58746 Applic. Date: 2007-08-22

Inventor: FOWLER CHRISTABEL [GB]


Application No.: US20100291164A1  Published: 18/Nov/2010

Title: FUNCTIONALIZED CALCIUM PHOSPHATE HYBRID SYSTEMS FOR THE REMINERALIZATION OF TEETH AND A METHOD FOR PRODUCING THE SAME

Applicant/Assignee:

Application No.: 12/465330   Filing Date: 13/May/2009

Abstract:A dental remineralizing system, including a functionalized calcium-containing complex having an organic surfactant component mechanochemically attached to a distressed calcium phosphate component and blended with the comestible material.

Priority:

Inventor: KARLINSEY ROBERT L [US]


Application No.: US20100291215A1  Published: 18/Nov/2010

Title: DRUG DELIVERY MATRICES TO ENHANCE WOUND HEALING

Applicant/Assignee: EIDGENOSSISCHE TECHNISCHE HOCHSCHULE UNIVERSITAT

Application No.: 12/845354   Filing Date: 28/Jul/2010

Abstract:Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGF[beta] superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.

Priority: US2007-739607 Applic. Date: 2007-04-24; US2002-132619 Applic. Date: 2002-04-25; US20010286307P Applic. Date: 2001-04-25

Inventor: SCHENSE JASON C [CH]; SCHMOEKEL HUGO [CH]; HUBBELL JEFFREY ALAN [CH]; WEBER FRANZ [CH]


Application No.: US20100291245A1  Published: 18/Nov/2010

Title: SOFT, CHEWABLE AND ORALLY DISSOLVABLE AND/OR DISINTEGRABLE PRODUCTS

Applicant/Assignee: PHILIP MORRIS USA INC

Application No.: 12/633247   Filing Date: 08/Dec/2009

Abstract:A soft, chewable and orally dissolvable and/or disintegrable product includes a biopolymer-sugar based matrix and botanical powder dispersed throughout the biopolymer-sugar based matrix. The biopolymer-sugar based matrix includes at least one biopolymer, at least one sugar and optional additives. Soft, chewable and orally dissolvable and/or disintegrable product can also include flavor beads.

Priority: US20080193574P Applic. Date: 2008-12-08

Inventor: GAO FENG [US]; GEDEVANISHVILI SHALVA [US]; LIU SHENGSHENG [US]; MISHRA MUNMAYA K [US]; SWEENEY WILLIAM R [US]; BAREN RANDALL [US]; LI QINGLIN [US]; COLASSACO DARIN [US]; CHOUCHANE SALEM [US]


Application No.: US20100291503A1  Published: 18/Nov/2010

Title: Tongue block

Applicant/Assignee:

Application No.: 12/653203   Filing Date: 10/Dec/2009

Abstract:The invention is a device for use as a prop to hold the mouth open which consists essentially of a bite block with an elongated portion that is deflected and to provide a physiologically shaped elongated portion extends along the buccal border of the tongue to form a tongue depressor and light reflector as the bite block is held in position. The retaining arm, tongue guiding hole and the flange retain the patient's tongue in the bottom cavity of the patient's mouth.

Priority: US2003-697932 Applic. Date: 2003-10-31

Inventor: SHIH J RICHARD [US]; SHIH STEPHANIE TZE-FAN [US]


Application No.: US20100291506A1  Published: 18/Nov/2010

Title: DEVICE FOR DEBRIDEMENT OF IMPLANTS, AND A METHOD FOR DEBRIDEMENT OF IMPLANTS USING THE DEVICE

Applicant/Assignee:

Application No.: 12/863630   Filing Date: 21/Jan/2009

Abstract:A device (10) for debridement of dental implants, which are arranged into bone tissue and are surrounded by gingiva of a jaw of a human being, has a debriding element (11) and an axle (12) with a fastener (13) for attachment to a rotational apparatus The debriding element (11) has at least one cleaning leg (20) with at least one cutting edge for engagement with the implant, the gingiva and/or the bone tissue According to a second embodiment the debriding element has several portions each having said cleaning leg (20) and the portions are connected to each other Said cleaning leg (20) has a free end (21) shaped as a hook (30) with a point (31), which is provided with said cutting edge The device (10) may have several cleaning legs (20), each provided with several cutting edges A method for cleaning and abrasion of dental implants and implant sites are provided, which uses the device (10)

for abrasion and cleaning.

Priority: SE20080000189 Applic. Date: 2008-01-25; WO2009EP50662 Applic. Date: 2009-01-21

Inventor: OLSSON LENNART [SE]; LINDBERG ANDERS [SE]; BANGE OLOF [SE]


Application No.: US20100292235A1  Published: 18/Nov/2010

Title: Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof

Applicant/Assignee:

Application No.: 12/225274   Filing Date: 16/Mar/2007

Abstract:Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20060782923P Applic. Date: 2006-03-16; US20060783121P Applic. Date: 2006-03-16; US20060783590P Applic. Date: 2006-03-16; US20060783748P Applic. Date: 2006-03-16; US20060831416P Applic. Date: 2006-07-17; US20060846993P Applic. Date: 2006-09-25; WO2007US06700 Applic. Date: 2007-03-16

Inventor: KELLY MICHAEL G [US]; KINCAID JOHN [US]; FANG YUNFENG [US]; HE JIANHUA [US]; CAO YEYU [US]; KAUB CARL [US]; GOWLUGARI SUMITHRA [US]; WANG ZHAN [US]


Application No.: US20100292236A1  Published: 18/Nov/2010

Title: 5-Membered Heterocyclic Amides And Related Compounds

Applicant/Assignee: H. LUNDBECK A/S

Application No.: 12/669308   Filing Date: 21/Jul/2008

Abstract:5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Priority: US20070950625P Applic. Date: 2007-07-19; WO2008US70613 Applic. Date: 2008-07-21

Inventor: LI HONGBIN [US]; YUAN JUN [US]; BAKTHAVATCHALAM RAJAGOPAL [US]; HODGETTS KEVIN J [US]; CAPITOSTI SCOTT M [US]; MAO JIANMIN [US]; WUSTROW DAVID J [US]; GUO QIN [US]


Application No.: US20100292254A1  Published: 18/Nov/2010

Title: Fused Pyrimidine Derivatives as Trpv3 Modulators

Applicant/Assignee: GLENMARK PHARMACEUTICALS, S.A

Application No.: 12/811975   Filing Date: 07/Jan/2009

Abstract:The present invention related to fused pyrimidine derivatives, which are useful as Transient Receptor Potential Vanilloid 3 (TRPV3) receptors, methods of treating deseases, disorders, conditions modulated by TRPV3. The present invention having the formula (I) and its pharmaceutically acceptable salts thereof, and its processes thereof, wherein all variables are as described herein.

Priority: IN2008MU00082 Applic. Date: 2008-01-11; IN2008MU00548 Applic. Date: 2008-03-18; IN2008MU00798 Applic. Date: 2008-04-04; US20080028770P Applic. Date: 2008-02-14; US20080048276P Applic. Date: 2008-04-28; WO2009IN00025 Applic. Date: 2009-01-07

Inventor: LINGAM V S PRASADARAO [IN]; THOMAS ABRAHAM [IN]; MORE DATTAGURU ANANDRAO [IN]; KHATIK JAVED YUSUF [IN]; KHAIRATKAR-JOSHI NEELIMA [IN]; KATTIGE VIDYA GANAPATI [IN]


Application No.: US20100292276A1  Published: 18/Nov/2010

Title: BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS

Applicant/Assignee:

Application No.: 12/773083   Filing Date: 04/May/2010

Abstract:The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

Priority: US20090178596P Applic. Date: 2009-05-15

Inventor: CALVO RAUL R [US]; MEEGALLA SANATH K [US]; PLAYER MARK R [US]


Application No.: US20100292294A1  Published: 18/Nov/2010

Title: Compositions Comprising a Physiological Coolant

Applicant/Assignee: GIVAUDAN NEDERLAND SERVICES B.V

Application No.: 12/529462   Filing Date: 03/Mar/2008

Abstract:The present invention concerns enhancements in the cooling effects of certain physiological coolant-containing compositions such as topically applied cosmetic, toiletry or pharmaceutical products, wherein the cooling effect of the physiological coolants is enhanced by the addition of a substance according to formula (I) or dermatologically acceptable salts thereof: R1-CR2(OR3)-CO-NR4-CR5R6-X-OR7 (I) It was found that substances represented by formula (I) are capable of bringing about greater cooling effects from reduced concentrations of physiological coolants without behaving as physiological coolants themselves, thereby enabling the preparation of compositions that do not necessarily have the characteristic minty odour of menthol-containing products and/or to allow greater freedom in creating perfumed products.

Priority: GB20070004163 Applic. Date: 2007-03-02; WO2008EP01644 Applic. Date: 2008-03-03

Inventor: WATSON MICHAEL STEVEN [GB]; WATKINS STEPHEN DAVID [GB]; TONDEUR SANDER [NL]


Application No.: US20100292359A1  Published: 18/Nov/2010

Title: Reaction-Curable Adhesive Composition and Dental Adhesive Kit

Applicant/Assignee: SUN MEDICAL CO., LTD

Application No.: 12/599821   Filing Date: 14/May/2008

Abstract:A reaction-curable adhesive composition exhibiting acidity is formed form a weakly acidic to alkaline composition (I) comprising (a) a polymerizable monomer and (b) a compound represented by the following formula (1) and a strongly acidic composition (II) comprising (a) a polymerizable monomer. R1-C6H4-NR2CH2COOR3 (1) wherein R1 and R2 are each independently a hydrogen atom or an alkyl group which may have a functional group, and R3 is a hydrogen atom or a metal atom. The composition containing the polymerizable monomer can be stably stored for a long period of time.

Priority: JP20070129346 Applic. Date: 2007-05-15; WO2008JP58868 Applic. Date: 2008-05-14

Inventor: YAMAMOTO TAKASHI [JP]; ONO TOSHIKI [JP]; ARATA MASAMI [JP]; ORI TATSUYA [JP]


Application No.: US20100292360A1  Published: 18/Nov/2010

Title: Pre-Treated Acid-Reactive Fillers and Their Use in Dental Applications

Applicant/Assignee: PENTRON CLINICAL TECHNOLOGIES, L.L.C

Application No.: 12/467448   Filing Date: 18/May/2009

Abstract:A dental filler and dental resin restorative composition containing the dental filler is provided. The dental filler is prepared by pre-treating an acid-reactive filler with a polymerizable monomer or oligomer pre-treatment chemical having at least one acid or acid-precursor functional group, at least one polymerizable unsaturated carbon-carbon bond, and a molecular weight of about 1,000 grams per mole or less.

Priority:

Inventor: JIA WEITAO [US]; JIN SHUHUA [US]


Application No.: US20100292362A1  Published: 18/Nov/2010

Title: Dental Composition Containing a Surfactant and an F-Containing Compound, Process of Production and Use Thereof

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/747927   Filing Date: 17/Dec/2008

Abstract:The invention relates to a curable dental composition comprising a) a curable organopolysiloxane polymer, b) a crosslinker compound capable of crosslinking said organopolysiloxane polymer, c) a catalyst capable of catalyzing a crosslinking reaction of component (A) and component (B), d) a surfactant, e) a F-containing compound, wherein the F-containing compound has the following formula: (G1-L1-O)s-Rfa-O-L2-G2 wherein: G1 and G2 each independently represents a non-ionic endgroup that is free of polyoxyalkylene groups or contains polyoxyalkylene such that the total amount thereof in the F-containing compound is not more than 10% by weight based on the molecular weight of the F-containing compound

L1 and L2 each independently represents an aliphatic hydrocarbon group or a partially or fully fluorinated aliphatic hydrocarbon group

Rfa represents a mono-valent or divalent partially or fully fluorinated aliphatic group or a partially or fully fluorinated aliphatic group interrupted by one or more oxygen atoms

with the proviso that at least one of the following conditions is fulfilled: (i) at least one of the moieties L1-G1 and L2-G2 is partially or fully fluorinated or (ii) Rf is a partially or fully fluorinated aliphatic group interrupted by one or more oxygen atoms. The invention also relates to a kit of parts and a method of producing a dental composition as well as the use of the dental composition for the preparation of or as impression material or for the preparation of crowns and bridges.

Priority: EP20070123485 Applic. Date: 2007-12-18; EP20080160310 Applic. Date: 2008-07-14; WO2008US87087 Applic. Date: 2008-12-17

Inventor: ZECH JOACHIM W [DE]; OSSWALD PETER U [DE]; HOFFMANN HENNING [DE]; MAURER ANDREAS R [DE]; BISSINGER PETER [DE]; HINTZER KLAUS [DE]


Application No.: US20100293731A1  Published: 25/Nov/2010

Title: ORAL CARE DEVICE WITH A FUNCTION ELEMENT

Applicant/Assignee:

Application No.: 12/849498   Filing Date: 03/Aug/2010

Abstract:An oral care device having a handle and a head connectible thereto, on which oral care elements are provided along with a function element. The device also includes a ramp disposed adjacent the function element.

Priority: EP20080015419 Applic. Date: 2008-09-01; WO2009IB53812 Applic. Date: 2009-09-01

Inventor: STIEF CHRISTIAN [DE]; HAAS MARTIN [DE]; STOERKEL JENS [DE]


Application No.: US20100294289A1  Published: 25/Nov/2010

Title: Filtered Cigarette Possessing Tipping Material

Applicant/Assignee: RJ REYNOLDS TOBACCO COMPANY

Application No.: 12/849487   Filing Date: 03/Aug/2010

Abstract:A filtered cigarette possesses a smokable rod and a filter element. The smokable rod is secured to the filter element using tipping material. The cigarette possesses more than one layer of tipping material. An outer layer of tipping material can overlie at least a portion of an underlying inner layer of tipping material, and during use by the smoker, the outer layer can be removed from the cigarette. Thus, it is possible for a cigarette manufacturer to provide a cigarette that can be used as such by the smoker, or that can be adapted by the smoker to provide a different sensory experience (e.g., the visual, organoleptic, trigeminal, aromatic, and tactile characteristics of the cigarette can be altered by removal of the outer tipping material). Alternatively, the use of the outer layer of tipping material can be used to improve the physical integrity of the cigarette.

Priority: US2006-462505 Applic. Date: 2006-08-04

Inventor: DUBE MICHAEL FRANCIS [US]; CHAPMAN PAUL STUART [US]


Application No.: US20100294291A1  Published: 25/Nov/2010

Title: Smokeless Tobacco

Applicant/Assignee:

Application No.: 12/852645   Filing Date: 09/Aug/2010

Abstract:A smokeless tobacco formulation includes particles or pieces of tobacco, and may include other ingredients, such as salts, sweeteners, binders, colorants, pH adjusters, fillers, flavoring agents, disintegration aids, antioxidants, humectants, and preservatives. The moisture content of the particles of the tobacco may vary. Certain smokeless tobacco products have the form of tobacco compositions or formulations that result from casting or otherwise forming a slurry incorporating tobacco material and other components as a film or sheet. Certain smokeless tobacco products have the form of tobacco compositions or formulations that result from pressing, extruding or otherwise forming a mixture incorporating tobacco material and other components into a desired shape. The foregoing tobacco products, as well as snus-type products, can be packaged under conditions of controlled atmosphere. Smokeless tobacco products can be sealed in outer packaging materials that are virtually impervious to oxygen and/or moisture, and those packaging materials can be vacuum sealed or sealed such that the atmosphere therewithin is essentially inert.

Priority: US2006-461628 Applic. Date: 2006-08-01

Inventor: ROBINSON JOHN HOWARD [US]; PALMER LAYA KATINA [US]; PATEL PANKAJ [US]; MUA JOHN-PAUL [US]; MONSALUD JR LUIS ROSETE [US]


Application No.: US20100294294A1  Published: 25/Nov/2010

Title: Dental floss strip, dental floss pick and method for manufacturing the bactericidal dental floss pick

Applicant/Assignee:

Application No.: 12/453678   Filing Date: 19/May/2009

Abstract:A dental floss pick with a bactericidal function includes a support body and a plurality of dental silks. The support body has a support portion and at least two suspended portions separated from each other and parallelly extended outwards from the support portion. Each dental silk has two ends respectively fixed on the two suspended portions. Each dental silk is composed of a first dental material and a second dental material, and the second dental material is composed of a plurality of nano-sized silver particles that are mixed into the first dental material. Therefore, when the twisted dental silks are stirred by a predetermined force, one part of the nano-sized silver particles that have been mixed in the first dental material may be separated from the first dental material.

Priority:

Inventor: WU CHIEN-CHUNG [TW]


Application No.: US20100294686A1  Published: 25/Nov/2010

Title: Morpholino Compound Microemulsion

Applicant/Assignee: SINCLAIR PHARMACEUTICALS LIMITED

Application No.: 12/742407   Filing Date: 19/Jul/2010

Abstract:An L2/L1 microemulsion composition comprising water, a compound of formula (I) wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, and a salt of a compound of formula (I).

Priority: GB20060025841 Applic. Date: 2006-12-22; WO2007GB04878 Applic. Date: 2007-12-19

Inventor: ARNEBRANT THOMAS [SE]


Application No.: US20100294770A1  Published: 25/Nov/2010

Title: Beverage container with removable top

Applicant/Assignee:

Application No.: 11/659410   Filing Date: 06/Sep/2005

Abstract:A beverage container (20) containing a removable lid (30), the container comprising a rim (24), a side wall (23) depending from the rim, a shoulder portion extending inwardly from the side wall, the removable lid comprising an edge (33) extending over the rim, and along the side wall, and against the shoulder portion thereby attaching the lid to the container.

Priority: AU20040905218 Applic. Date: 2004-09-13; AU20040906885 Applic. Date: 2004-12-02; AU20040906886 Applic. Date: 2004-12-02; AU20050900448 Applic. Date: 2005-02-02; AU20050901560 Applic. Date: 2005-03-31; AU20050903600 Applic. Date: 2005-07-07; WO2005AU01350 Applic. Date: 2005-09-06

Inventor: WING DOMINIC JOHN [AU]; MALOUF CALILE DAMIEN [AU]; MALOUF MICHAEL CALILE [AU]; FARLEY SCOT [AU]


Application No.: US20100294812A1  Published: 25/Nov/2010

Title: INTERNAL CONTAINER BORE MOUNT FITMENT

Applicant/Assignee: PORTOLA PACKAGING, INC

Application No.: 12/848571   Filing Date: 02/Aug/2010

Abstract:In an embodiment of the invention there is provided a membrane fitment designed and sized to be inserted into the orifice defined by a container. Retention structure on the fitment cooperates with complimentary structure on the internal wall of the container orifice to secure the fitment within the orifice such that the combination forms an excellent primary seal. Tamper evidence is offered by the normal requirement for initial membrane removal. Novel designs for the membrane, its associated pull ring, and the frangible removal structure are taught in various embodiments. The novel designs may promote facile initial removal suitable for a child. In addition, the novel designs avoid the potential hazards presented by prior art membranes.

Priority: US2009-520459 Applic. Date: 2009-09-25; WO2007US88538 Applic. Date: 2007-12-21; US20060871723P Applic. Date: 2006-12-22

Inventor: LOHRMAN RICHARD [US]; HENNESSY THOMAS [US]; KIM SUNGSUK STEVE [US]


Application No.: US20100295211A1  Published: 25/Nov/2010

Title: Method for Producing a Vessel Closure

Applicant/Assignee: ACTEGA DS GMBH

Application No.: 12/741722   Filing Date: 07/Nov/2008

Abstract:The invention relates to a method for producing a vessel closure for vessels comprising an opening that is to be closed by the vessel closure, an inner diameter of more than two cm and surrounds a polymer-based sealing element that is arranged in the vessel closure in such a manner that is sealingly rests on the opening of the vessel in the closed state. A polymer material becomes sufficiently free-flowing by warming and is applied to the vessel closure in the region of the sealing element that is to be produced, and optionally, is mechanically formed into the desired shape which it maintains after cooling. The invention also relates to a metal or plastic vessel closures for vessels for receiving drinks or food, and comprises a sealing insert, the material thereof being selected so that the migration of material components into the drink or food, that are a health risk, is prevented. The invention also relates to corresponding materials for said type of sealing inserts and to the use of specific polymers for producing the above-mentioned sealing inserts.

Priority: EP20070021782 Applic. Date: 2007-11-09; EP20080002379 Applic. Date: 2008-02-08; WO2008EP09421 Applic. Date: 2008-11-07

Inventor: POEL-ASENDORF CHRISTIANE [DE]; WITTENBERG RUEDIGER [DE]; SCHLENK GEORG [DE]


Application No.: US20100296756A1  Published: 25/Nov/2010

Title: BAG INCLUDING CLOSURE PROFILES ACTUATED BY A SLIDER

Applicant/Assignee: S2F FLEXICO

Application No.: 12/745871   Filing Date: 21/Jan/2009

Abstract:The invention relates to a bag (1) that comprises two substantially parallel sheets (12, 13) defining the main walls thereof, complementary closing profiles (2, 3) respectively attached to said sheets (12, 13), and a slider (5) for actuating the profiles (2, 3) upon opening or closing. The bag is characterised in that at least one of said sheets (12, 13) includes, on the outer face thereof, in the vicinity of the gripping area of the slider (5) and parallel to the movement direction of the latter, a strip-shaped bead defining a build up having a thickness and a width sufficient for locally modifying the deformability thereof.

Priority: FR20080050394 Applic. Date: 2008-01-22; WO2009EP50654 Applic. Date: 2009-01-21

Inventor: BOIS HENRI [FR]


Application No.: US20100296859A1  Published: 25/Nov/2010

Title: Microbes Detecting and Treating Toothbrush

Applicant/Assignee:

Application No.: 12/811488   Filing Date: 08/Jan/2009

Abstract:A microbe detecting and/or treating toothbrush that includes a handle that comprises a head portion, a neck portion and a grasping portion, an upper surface and a lower surface

a plurality of bristles, positioned on and attached to the upper surface of the head portion of the handle and a dental hygiene device being parts of the handle, which comprises a dispensing aperture from which an effective amount of a disclosing and/or treating agent is dispensed and a dispensing mechanism comprising an actuator, which upon actuation, enables the dispensing aperture to provide an effective amount of a disclosing and/or treating agent, wherein the dispensing aperture and the dispensing mechanism of the dental hygiene devices are situated in the neck portion or the grasping portion of the handle.

Priority: US20080019621P Applic. Date: 2008-01-08; WO2009IL00027 Applic. Date: 2009-01-08

Inventor: LERNER SHARON [IL]; LERNER SAM [IL]; ARBISER URI [IL]


Application No.: US20100297037A1  Published: 25/Nov/2010

Title: MATERIAL COMPOSITION FOR ORAL HYGIENE PRODUCT

Applicant/Assignee:

Application No.: 12/680399   Filing Date: 02/Oct/2008

Abstract:The present invention relates to a material composition, particularly for an oral hygiene product suitable for combating caries and also for combating parodontitis and gingivitis. Said material composition or oral hygiene product is characterized in that it comprises an extract of Curcuma xanthorrhiza or xanthorrhizol and folic acid.

Priority: DE200710047237 Applic. Date: 2007-10-02; WO2008EP08386 Applic. Date: 2008-10-02

Inventor: BUSCH KLAUS-UWE [AT]


Application No.: US20100297197A1  Published: 25/Nov/2010

Title: Non-fluoride containing dietary supplement toothpaste and methods of using the same

Applicant/Assignee:

Application No.: 12/454674   Filing Date: 21/May/2009

Abstract:A non-fluoride containing toothpaste enriched with at least one dietary supplement. The non-fluoride containing toothpaste comprising a dentally acceptable oral vehicle containing a sufficient amount of thickening agent to impart a pasty consistency

and at least one dietary supplement wherein a serving size portion of the non-fluoride containing toothpaste contains more than about 2 percent of the reference daily intake (RDI) of the dietary supplement.

Priority:

Inventor: GOLDEN BRUCE ALAN [US]


Application No.: US20100297200A1  Published: 25/Nov/2010

Title: USE OF NITRIC OXIDE TO ENHANCE THE EFFICACY OF SILVER AND OTHER TOPICAL WOUND CARE AGENTS

Applicant/Assignee: THE UNIVERSITY OF NORTH CAROLINA ATCHAPEL HILL

Application No.: 12/682305   Filing Date: 10/Oct/2008

Abstract:The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpected synergistic effects, wherein both the antimicrobial efficacy of the nitric oxide and the antimicrobial or wound healing efficacy of the second therapeutically active agent are enhanced. As a result, a patient may benefit from reduced dosage requirements and a reduced likelihood of antimicrobial resistance. The composition may be formulated for local or systemic administration, for topical applications as well as for use in coatings for medical supplies and devices.

Priority: US20070998740P Applic. Date: 2007-10-12; WO2008US79582 Applic. Date: 2008-10-10

Inventor: SCHOENFISCH MARK A [US]; HETRICK EVAN M [US]; STASKO NATHAN A [US]; JOHNSON C BRYCE [US]


Application No.: US20100297203A1  Published: 25/Nov/2010

Title: IMPACT OF CALCIUM PHOSPHATE COMPLEX ON DENTAL CARIES

Applicant/Assignee: CADBURY ADAMS USA, LLC

Application No.: 12/851012   Filing Date: 05/Aug/2010

Abstract:The present invention relates to chewing gum and confectionery compositions and methods for reducing dental caries in mammals. In particular, the compositions may include a gum base or carrier, sweetening agents and casein phosphopeptide-calcium phosphate (CPP-ACP). The compositions may be employed to slow the progression and enhance the regression of carious lesions in mammals, particularly in humans.

Priority: US2007-732854 Applic. Date: 2007-04-05; US20060789525P Applic. Date: 2006-04-05

Inventor: TANCREDI DORIS [US]; MING DING [US]; VINCENT JACK W [US]


Application No.: US20100297229A1  Published: 25/Nov/2010

Title: TAPENTADOL COMPOSITIONS

Applicant/Assignee: NECTID INC

Application No.: 12/786382   Filing Date: 24/May/2010

Abstract:The present invention provides a method of treating pain and pain related conditions by administering to a patient in need thereof, a therapeutically effective amount of a slow release Tapentadol Hydrochloride and therapeutically effective amount of a second analgesic, wherein the second analgesic is tramadol, gamma-aminobutyric acid (GABA) analogue or an NSAID. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a slow release Tapentadol Hydrochloride and a therapeutically effective amount of a second analgesic, wherein the second analgesic is tramadol, gamma-aminobutyric acid (GABA) analogue or an NSAID.

Priority: WO2008US84423 Applic. Date: 2008-11-21; US20070004029P Applic. Date: 2007-11-23

Inventor: SESHA RAMESH [US]


Application No.: US20100297236A1  Published: 25/Nov/2010

Title: HYBRID INDUCIBLE RELEASE VEHICLE

Applicant/Assignee:

Application No.: 12/677928   Filing Date: 15/Sep/2008

Abstract:The invention is directed to a hybrid inducible release vehicle, to a method for preparing such a vehicle, and to the use thereof. The hybrid inducible release vehicle of the invention comprises a gel, which gel comprises a cross-linked carbohydrate and/or protein polymer and an inorganic carrier, and at least one active ingredient bound to said inorganic carrier, wherein the release of the active ingredient is triggered by contact of the vehicle with an external stimulus.

Priority: EP20070116508 Applic. Date: 2007-09-14; WO2008NL50603 Applic. Date: 2008-09-15

Inventor: SLAGHEK THEODOOR MAXIMILIAAN [NL]; TIMMERMANS JOHANNES WILHELMUS WILHELMUS [NL]; BATENBURG LAWRENCE FABIAN [NL]; VAN EE RENZ JEROEN [NL]


Application No.: US20100297319A1  Published: 25/Nov/2010

Title: Device and method for twisting elongated dough strips

Applicant/Assignee: RADEMAKER B.V

Application No.: 12/773297   Filing Date: 04/May/2010

Abstract:The present invention relates to a device for twisting elongated dough strips, comprising at least one pair of grippers, each arranged for gripping and respectively releasing one short side of a dough strip, and means for mutually rotating the grippers around an axis of rotation. In an embodiment, the device comprises a first conveyor for supplying dough strips oriented with their long sides perpendicular to the direction of conveyance wherein the width of the first conveyor is chosen smaller than the long sides of the dough strips so that the short sides of a dough strip protrude from the first conveyor, and a second conveyor for carrying off the twisted dough strips. The invention further provides a method for twisting an elongated dough strip.

Priority: EP20090160658 Applic. Date: 2009-05-19

Inventor: VAN BLOKLAND JOHANNES JOSEPHUS ANTONIUS [NL]


Application No.: US20100297540A1  Published: 25/Nov/2010

Title: SULPHONIUM SALT INITIATORS

Applicant/Assignee: BASF SE

Application No.: 12/681785   Filing Date: 22/Sep/2008

Abstract:Compounds of the Formula (I), wherein L1, L'1, L''1, L2, L'2, L''2, L3, L'3, L''3, L4, L'4 and L''4 for example are hydrogen or COT

R, R' and R'' for example are hydrogen, C6-C12aryl or C3-C20heteroaryl

X, X' and X'' for example are O, S, single bond, NRa or NCORa, T is for example hydrogen, C1-C20alkyl, C3-C12cycloalkyl, C2-C20alkenyl, C5-C12cycloalkenyl, C7-C18cycloalkylenaryl, C5-C18cycloalkylenheteroaryl, C6-C14aryl, providedthat at least one of R, R' or R'' is unsubstituted or substituted C3-C20heteroaryl

and Y is an inorganic or organic anion

are suitable as photolatent acid generators.

Priority: EP20070118194 Applic. Date: 2007-10-10; WO2008EP62587 Applic. Date: 2008-09-22

Inventor: HAYOZ PASCAL [CH]; YAMATO HITOSHI [JP]; ASAKURA TOSHIKAGE [JP]


Application No.: US20100297541A1  Published: 25/Nov/2010

Title: SULPHONIUM SALT INITIATORS

Applicant/Assignee: BASF SE

Application No.: 12/681786   Filing Date: 29/Sep/2008

Abstract:Compounds of the formula (I), wherein X is a single bond, CRaRbO, S, NRc or NCORc

Z is formula (II) or C3-C20heteroaryl

L, L1, L2, L3, L4, L5, L6, L7 and L8 for example independently of one another are hydrogen or an organic substituent

Ra, Rb and Rc independently of one another are hydrogen or an organic substituent

R is for example is C5-C20heteroaryl or C6-C14 aryl

and Y is an inorganic or organic anion

are suitable as photolatent acid generators.

Priority: EP20070118204 Applic. Date: 2007-10-10; WO2008EP62991 Applic. Date: 2008-09-29

Inventor: HAYOZ PASCAL [CH]; YAMATO HITOSHI [JP]; ASAKURA TOSHIKAGE [JP]


Application No.: US20100297542A1  Published: 25/Nov/2010

Title: SULPHONIUM SALT INITIATORS

Applicant/Assignee: BASF SE

Application No.: 12/681784   Filing Date: 29/Sep/2008

Abstract:Compounds of the formula (I), wherein X is a single bond, CRaRb O, S, NRC, NCORC, CO, SO or SO2

L, L1, L2, L3, L4, L5, L6, L7 and L8 are for example hydrogen, R1 or COT

T denotes T1 or O-T2

T1 and T2 for example are hydrogen, C1-C20alkyl, C3-C12cycloalkyl, C2-C20alkenyl, C5-C12cycloalkenyl, C6-C14aryl, C3-C12heteroaryl, C1-C20alkyl substituted by one or more D, C2-C20alkyl interrupted by one or more E, C2-C20alkyl substituted by one or more D and interrupted by one or more E or Q

R1, R2, R3, R4, Ra, Rb and Rc are T1

D is for example R5, OR5, SR5 or Q1

E is for example O, S, COO or Q2

R5 and R6 for example are hydrogen, C1-C12alkyl or phenyl

Q is for example C6-C12bicycloalkyl, C6-C12bicycloalkenyl or C6-C12tricycloalkyl

Q1 is for example, C6-C14aryl or C3-C12heteroaryl

Q2 is for example C6-C14arylene or C3-C12heteroarylene

Y is an anion

and M is a cation

provided that at least one of L, L1, L2, L3, L4, L5, L6, L7 and L8 is other than hydrogen

and provided that (i) at least one of T1 or T2 is a group Q

or (ii) at least one D is a group Q1

or (iii) at least one E is a group Q2

are suitable as photolatent catalysts.

Priority: EP20070118195 Applic. Date: 2007-10-10; WO2008EP62988 Applic. Date: 2008-09-29

Inventor: HAYOZ PASCAL [CH]; YAMATO HITOSHI [JP]


Application No.: US20100297577A1  Published: 25/Nov/2010

Title: Strainer/filter unit for an aspirating filtration system and method thereof

Applicant/Assignee:

Application No.: 12/454771   Filing Date: 22/May/2009

Abstract:A strainer/filter unit for effectively collecting solid, liquid or gaseous substances at the source and the method of using the strainer/filter unit. The strainer/filter unit includes a housing, a one-way valve at one end of the housing, and a filter having a certain depth and thickness within the housing. The filter is formed from a plurality of layers of material with pores such that pores of one layer partially overlap pores of subsequent adjacent layers. Matters entering the strainer/filter unit are collected in the filter while travelling through filter via a tortuous path.

Priority:

Inventor: COHEN HOWARD [US]


Application No.: US20100297579A1  Published: 25/Nov/2010

Title: Brace for holding a patient's mouth open during dental procedures

Applicant/Assignee:

Application No.: 12/454623   Filing Date: 19/May/2009

Abstract:A dental device includes a generally C-shaped member with upper and lower arms and a central spring arm extending therebetween. Rubber cradle members on the upper and lower arms comfortably engage the top and bottom teeth, while the spring arm urges the arm members apart. In a preferred embodiment, the rubber cradle members are fitted onto distal end positions of the upper and lower arms and are locked in place by serrated members on the distal end portions, thereby preventing slipping or accidental removal of the rubber cradles. Alternatively, the rubber cradle members may be permanently applied to the distal end portions by a dipping and coating process. When inserted and properly positioned between the upper and lower teeth, the device holds the mouth open and permits full access and movement of dental tools within the mouth in the performance of basic dental procedures, while eliminating strain on the patient's jaw muscles.

Priority:

Inventor: BELOFF ARTHUR L [US]


Application No.: US20100297588A1  Published: 25/Nov/2010

Title: DENTAL COMPOSITIONS WITH NATURAL TOOTH FLUORESCENCE AND METHODS

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/740528   Filing Date: 29/Oct/2008

Abstract:Hardenable dental compositions which include a fluorescent diether terephthalate and a resin system, such that when hardened, the compositions have a natural tooth fluorescence, methods of making the compositions, and dental articles made from the compositions are disclosed.

Priority: US20070984785P Applic. Date: 2007-11-02; WO2008US81573 Applic. Date: 2008-10-29

Inventor: KALGUTKAR RAJDEEP S [US]; KOBUSSEN GREGORY A [US]


Application No.: US20100298225A1  Published: 25/Nov/2010

Title: PEPTIDE GAP JUNCTION MODULATORS

Applicant/Assignee:

Application No.: 12/669351   Filing Date: 14/Jul/2008

Abstract:Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).

Priority: DK20070001044 Applic. Date: 2007-07-15; US20070959650P Applic. Date: 2007-07-16; WO2008GB02405 Applic. Date: 2008-07-14

Inventor: LARSEN BJARNE DUE [DK]; DELMAR MARIO [US]; TAFFET STEVEN M [US]; COOMBS WANDA [US]


Application No.: US20100298285A1  Published: 25/Nov/2010

Title: Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof

Applicant/Assignee:

Application No.: 12/225275   Filing Date: 16/Mar/2007

Abstract:Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20060783304P Applic. Date: 2006-03-16; US20060782973P Applic. Date: 2006-03-16; US20060782782P Applic. Date: 2006-03-16; US20070918124P Applic. Date: 2007-03-15; WO2007US06721 Applic. Date: 2007-03-16

Inventor: KELLY MICHAEL G [US]; KINCAID JOHN [US]; FANG YUNFENG [US]; HE JIANHUA [US]; CAO YEYU [US]; KAUB CARL [US]; GOWLUGARI SUMITHRA [US]; WANG ZHAN [US]


Application No.: US20100298380A1  Published: 25/Nov/2010

Title: N-ARYL-N-PIPERIDIN-4-YLMETHYL-AMIDE DERIVATIVES AND THIER USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/671592   Filing Date: 31/Jul/2008

Abstract:This invention relates to novel N-aryl-N-piperidin-4-ylmethyl amide derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20070001114 Applic. Date: 2007-08-02; US20070953750P Applic. Date: 2007-08-03; WO2008EP60034 Applic. Date: 2008-07-31

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; MUNRO GORDON [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100298462A1  Published: 25/Nov/2010

Title: Self-cure activator

Applicant/Assignee:

Application No.: 12/283954   Filing Date: 17/Sep/2008

Abstract:A self curing activator for chemical polymerization of the interface of a dental bonding agent and a self curing or dual curing dental cement or restorative, includes an aryl borate compound, a polymerizable monomer, an optional acidic compound, an amine compound which exhibits a catalytic action, an organic peroxide containing material, and a metal compound wherein said metal compound promotes the decomposition of the organic peroxide.

Priority: US2006-501342 Applic. Date: 2006-08-09; US2006-351040 Applic. Date: 2006-02-08; US20050651030P Applic. Date: 2005-02-08

Inventor: LIU HUAIBING [US]; HAMMESFAHR PAUL D [US]; POMRINK GREGORY [US]


Application No.: US20100298529A1  Published: 25/Nov/2010

Title: MANUFACTURE AND USE OF MODIFIED POLYSACCHARIDE CHITOSAN BONDS AND A PROCESS TO IMPROVE THE PREPARATION OF HES-MEDICINAL SUBSTANCE COMPOUNDS

Applicant/Assignee:

Application No.: 12/293784   Filing Date: 26/Apr/2007

Abstract:The invention relates to a bonding product suitable as a carrier for medicinal substances and to the compound derived therefrom that carries medicinal substances. The invention further relates to a process and device for preparing such bonding products and compounds. Further, the invention relates to a pharmaceutical composition containing such bonding products and compounds, and to the use thereof for preparing an infusible medicament for treating a disease.

Priority: DE200610020035 Applic. Date: 2006-04-26; WO2007EP54124 Applic. Date: 2007-04-26

Inventor: MEIER BERND HORST [DE]; MEIER NELE [DE]


Application No.: US20100298547A1  Published: 25/Nov/2010

Title: METHODS FOR THE DIRECTED EXPANSION OF EPITOPES FOR USE AS ANTIBODY LIGANDS

Applicant/Assignee:

Application No.: 12/451323   Filing Date: 07/May/2008

Abstract:The instant invention comprises a process for selecting and manufacturing antibodies useful for therapeutic, prophylactic, diagnostic or research purposes using epitope peptide mixtures synthesized by the solid phase synthesis, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting antibodies are related to but distinct from antibodies that bind to the known epitope.

Priority: US20070928225P Applic. Date: 2007-05-07; US20070999283P Applic. Date: 2007-10-16; US20070999284P Applic. Date: 2007-10-16; US20080124689P Applic. Date: 2008-04-17; WO2008US05919 Applic. Date: 2008-05-07

Inventor: BONNIN DUSTAN [US]


Application No.: US20100298738A1  Published: 25/Nov/2010

Title: VESSEL, COATING, INSPECTION AND PROCESSING APPARATUS

Applicant/Assignee:

Application No.: 12/779007   Filing Date: 12/May/2010

Abstract:Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

Priority: US20090177984P Applic. Date: 2009-05-13; US20090222727P Applic. Date: 2009-07-02; US20090213904P Applic. Date: 2009-07-24; US20090234505P Applic. Date: 2009-08-17; US20090261321P Applic. Date: 2009-11-14; US20090263289P Applic. Date: 2009-11-20; US20090285813P Applic. Date: 2009-12-11; US20100298159P Applic. Date: 2010-01-25; US20100299888P Applic. Date: 2010-01-29; US20100318197P Applic. Date: 2010-03-26; US20100333625P Applic. Date: 2010-05-11

Inventor: FELTS JOHN T [US]; FISK THOMAS E [US]; ABRAMS ROBERT S [US]; FERGUSON JOHN [US]; FREEDMAN JONATHAN R [US]; PANGBORN ROBERT J [US]; SAGONA PETER J [US]


Application No.: US20100299858A1  Published: 02/Dec/2010

Title: DEVICE FOR CLEANING TEETH AND/OR MOUTH

Applicant/Assignee: BRAUN GMBH

Application No.: 12/598558   Filing Date: 28/Apr/2008

Abstract:The invention relates to a device for dental and/or oral care, especially a toothbrush, comprising a preferably rod-shaped tool support to which a cleaning tool, especially a bristle field, can be fastened. The tool support is configured as a composite body that comprises an enveloping body from a first material, preferably plastic material, and a functional body from a second material, preferably metal, which is embedded in the enveloping body. The dental and/or oral care device is characterized in that the functional body is configured in at least some sections thereof as a trelliswork girder frame that has longitudinal girders substantially extending in the longitudinal direction of the tool support and a plurality of cross-girders. The enveloping body is especially transparent so that the functional body is visible through the enveloping body.

Priority: DE200710019908 Applic. Date: 2007-04-27; WO2008EP03445 Applic. Date: 2008-04-28

Inventor: SCHAMBER STEFAN [DE]; STOERKEL JENS [DE]; WINKLER TILMANN [DE]; VITT MARTIN [DE]; PFEIFER ULRICH [DE]


Application No.: US20100299881A1  Published: 02/Dec/2010

Title: Multistep Occluding Zipper with Sealing Features

Applicant/Assignee:

Application No.: 12/476845   Filing Date: 02/Jun/2009

Abstract:A closure device for a thermoplastic bag which includes two opposing, longitudinally extending interlockable male and female fastening strips having respective male and female closure elements or profiles with outside wings that are deformed when the closure device is fully occluded.

Priority:

Inventor: BORCHARDT MICHAEL G [US]; NELTNER ANDREW E [US]


Application No.: US20100300230A1  Published: 02/Dec/2010

Title: Device for Movement Between an Input Member and an Output Member

Applicant/Assignee: FORCE DIMENSION

Application No.: 12/738015   Filing Date: 17/Aug/2010

Abstract:A device for the relative movement between an input member and an output member, the device comprising an input member (100)

an output member (108)

an intermediate member (104) coupling the input member (100) and the output member (108)

a first kinematics bond (102) coupling the intermediate member (104) and the input member (100)

the first kinematics bond (102) providing at least two rotational degrees of freedom

and a second kinematics bond (106) coupling the intermediate member (104) and the output member (108), the second kinematics bond (106) being adapted to transmit rotational motions between the intermediate member (104) and the output member (108) and to offset rotation axes of at least two rotational degrees of freedom of the output member (108).

Priority: EP20070020499 Applic. Date: 2007-10-19; WO2007EP09143 Applic. Date: 2007-10-22

Inventor: HELMER PATRICK [CH]


Application No.: US20100300615A1  Published: 02/Dec/2010

Title: PRODUCTION METHOD OF ORTHODONTIC BRACKET WITH POSITIONING GUIDE

Applicant/Assignee: GC CORPORATION

Application No.: 12/791497   Filing Date: 01/Jun/2010

Abstract:An orthodontic bracket with a positioning guide is produced by thinly coating a first dental photopolymerizable composition 1 on a bonding surface of each orthodontic bracket B, building a second dental photopolymerizable composition 2 adhesive to the first composition 1 on the bonding surface, adhering it to a tooth surface of a dentition gypsum model 3 reproducing a patient's dentition, a separating material being previously coated on the tooth surface of the gypsum model 3, polymerizing/curing the first and second compositions 1 and 2 by irradiating light, thinly coating a third dental photopolymerizable composition 4 on a tongue side and/or a cheek side entire surface around the orthodontic bracket B on the gypsum model 3, the third composition 4 being easily abraded when an occlusal pressure is acted, and polymerizing/curing the third composition 4 by irradiating light to be integrated with at least the second composition 2.

Priority: JP20090132466 Applic. Date: 2009-06-01

Inventor: KOMORI AKIRA [JP]


Application No.: US20100300921A1  Published: 02/Dec/2010

Title: PROVIDING TOOTHPASTE BEADS POSITIONED ON DISPENSING MEDIUM

Applicant/Assignee:

Application No.: 12/788295   Filing Date: 26/May/2010

Abstract:Systems and methods to dispense toothpaste include toothpaste beads positioned onto a dispensing medium. The toothpaste beads may be individually stored and accessed for use on a toothbrush.

Priority: US20090181267P Applic. Date: 2009-05-26

Inventor: SCHOLER JOELLE J [US]


Application No.: US20100303388A1  Published: 02/Dec/2010

Title: Draw Tape Bag

Applicant/Assignee:

Application No.: 12/471727   Filing Date: 26/May/2009

Abstract:The bag may include a draw tape that may be used to cinch closed the opening of the bag. The draw tape has at least one stretched elastomeric strip attached to the draw tape in an extended condition. The draw tape may be smaller in size than the bag sidewalls. The draw tape may include an elastic characteristic, such as patterned ribs. In one embodiment, the roll of bag is kept under tension to maintain the elastomeric strips in a stretched condition.

Priority:

Inventor: KENT GREGORY STUART [US]; BROERING SHAUN T [US]


Application No.: US20100303722A1  Published: 02/Dec/2010

Title: ARTICLES COMPRISING LARGE-SURFACE-AREA BIO-COMPATIBLE MATERIALS AND METHODS FOR MAKING AND USING THEM

Applicant/Assignee:

Application No.: 12/305887   Filing Date: 22/Jun/2007

Abstract:The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO2 or related metal and metal oxide films.

Priority: US20060816221P Applic. Date: 2006-06-23; WO2007US71947 Applic. Date: 2007-06-22

Inventor: JIN SUNGHO [US]; OH SEUNGHAN [US]


Application No.: US20100303737A1  Published: 02/Dec/2010

Title: Tooth-Cleaning Formulation

Applicant/Assignee:

Application No.: 12/792278   Filing Date: 02/Jun/2010

Abstract:A tooth-cleaning formulation which contains Himalaya salt in an unadulterated and also non-heat-treated form and/or Sango coral, with the Himalaya salt being used as a direct natural raw material and not being heated and sterilized itself.

Priority: DE200920007704U Applic. Date: 2009-06-02

Inventor: HURTIG SVEN [DE]


Application No.: US20100303739A1  Published: 02/Dec/2010

Title: Highly Concentrated Fatty Alcohol Sulfate Preparation

Applicant/Assignee: COGNIS IP MANAGEMENT GMBH

Application No.: 12/678041   Filing Date: 06/Sep/2008

Abstract:Concentrated fatty alcohol sulfate preparations which comprise at least 35% by weight of fatty alcohol sulfate (FAS) are described. The compositions are aqueous, but, besides the FAS, also comprise polyols, fatty acid alkylamides and/or oil-soluble betaines. They are suitable for the production of detergents and cleaners, but also for the production of cosmetic compositions, in particular dental care compositions.

Priority: EP20070018144 Applic. Date: 2007-09-14; WO2008EP07295 Applic. Date: 2008-09-06

Inventor: SPOERER ROLAND [MX]; JARIYACHAT SRARAT [TH]; WAWORUNTU TEDY [ID]; JAZULI ACHMAD [ID]; TAUFIK ACHMAD [ID]


Application No.: US20100303741A1  Published: 02/Dec/2010

Title: WOLFBERRIES AND INFLAMMATION

Applicant/Assignee: NESTEC S.A

Application No.: 12/677978   Filing Date: 12/Sep/2008

Abstract:The present invention relates in general to the field of inflammation. In particular the present invention relates to the use of natural compounds for the preparation of a product to treat or prevent inflammation. For example an extract of wolfberry was shown to have anti-inflammatory properties. One embodiment of the present invention relates to the use of a primary composition comprising wolfberries or a part thereof for the preparation of a product to treat or prevent inflammation.

Priority: EP20070116190 Applic. Date: 2007-09-12; WO2008EP62122 Applic. Date: 2008-09-12

Inventor: VIDAL KARINE [CH]; BLUM-SPERISEN STEPHANIE [CH]; PHILIPPE DAVID [CH]; BALLEVRE OLIVIER [CN]; BUCHELI PETER [CN]; WANG JUNKUAN [CH]


Application No.: US20100303925A1  Published: 02/Dec/2010

Title: REMINERALISATION OF CALCIFIED TISSUE

Applicant/Assignee: THE UNIVERSITY OF DUNDEE THE UNIVERSITY OF ABERTAY UNIVERSITY COURT OF THE UNIVERSITY OF SAINT ANDREWS

Application No.: 12/668684   Filing Date: 21/Apr/2009

Abstract:The disclosure concerns cosmetic and therapeutic treatment of tissue, such as tooth, to effect, for instance, whitening and tissue re-building through mineralisation and including kits for use in the methods.

Priority: GB20080007224 Applic. Date: 2008-04-21; WO2009GB01009 Applic. Date: 2009-04-21

Inventor: PITTS NIGEL [GB]; LONGBOTTOM CHRISTOPHER [GB]; CRAYSTON JOSEPH [GB]; GRINEV DMITRI [GB]; YOUNG IAN MCEWING [GB]


Application No.: US20100304284A1  Published: 02/Dec/2010

Title: THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS

Applicant/Assignee:

Application No.: 12/445756   Filing Date: 15/Oct/2007

Abstract:The invention relates to a cationic photocurable composition comprising at least one cationically polymerizable compound, at least one onium salt photoinitiator, at least a moisture scavenger, and at least a stabilizer selected from the group consisting of sterically hindered nitroxyl stabilizers, sterically hindered phenolic antioxidants, organic phosphorous stabilizers and mixtures thereof.

Priority: EP20060122783 Applic. Date: 2006-10-24; WO2007EP60924 Applic. Date: 2007-10-15

Inventor: RINKER KARSTEN [DE]


Application No.: US20100304323A1  Published: 02/Dec/2010

Title: Dental Color Key

Applicant/Assignee:

Application No.: 12/771873   Filing Date: 30/Apr/2010

Abstract:The invention relates to a dental color key comprising at least two different color patterns or samples with different tooth colors. The entire surface area of the color key (10) is smaller than the buccal and/or labial surface area, that is to say the vestibular surface area of two teeth, and the color patterns or samples (12) are attached adjacent to one another and particularly mounted to one single tooth.

Priority: EP20090161608 Applic. Date: 2009-05-29

Inventor: ROHNER GOTTFRIED [CH]; BERTSCH DIETHARD [AT]; BROTZGE MICHAEL [AT]


Application No.: US20100304325A1  Published: 02/Dec/2010

Title: Elastically Deformable Bite Fork Stabilizer and Associated Methods

Applicant/Assignee:

Application No.: 12/693575   Filing Date: 26/Jan/2010

Abstract:Methods and apparatus for stabilizing a bite fork in a patient's mouth. The apparatus may comprise an elastically deformable bite fork stabilizer. The elastically deformable bite fork stabilizer may comprise an elastically deformable layer, an adhesive layer on one side of the elastically deformable layer, and a removable layer adhered to the adhesive layer.

Priority:

Inventor: FLETCHER GAYLE J [US]


Application No.: US20100304334A1  Published: 02/Dec/2010

Title: Dental Implant System and Method of Use

Applicant/Assignee:

Application No.: 12/616756   Filing Date: 11/Nov/2009

Abstract:A dental implant system includes an implant having a well and an abutment having a post shaped to be received in the tapered well. Both the implant and the abutment are made from a millable ceramic, and the abutment post and/or the implant well have grooves carved therein. In one embodiment, the implant and the abutment are joined one to the other with a retentive elastomeric product containing micro-bubbles and micro-spacers. The dental implant system may be produced using a computer-readable medium containing instructions for analyzing surface data and X-ray data, for developing contour data of the implant and of the abutment according to the anatomy of the patient, and for generating machine instruction for milling the implant and the abutment from blocks of the millable ceramic. The invention provides the dentist with total flexibility in determining the most appropriate contours of the implant system and in reducing inventory.

Priority: US20090182967P Applic. Date: 2009-06-01

Inventor: LAYTON GRANT H [US]


Application No.: US20100304338A1  Published: 02/Dec/2010

Title: POLYMER IMPRESSION MATERIALS

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO

Application No.: 12/678801   Filing Date: 17/Sep/2008

Abstract:This invention relates to methods and compositions for single component photoinitiated dental impression materials. The impression material is workable in its pre-cured state, cures rapidly upon exposure to light, and exhibits desirable processing conditions such as short setting time, long working time, no void formation, good wettability, mechanical properties, and detail reproduction.

Priority: US20070973666P Applic. Date: 2007-09-19; WO2008US76639 Applic. Date: 2008-09-17

Inventor: CRAMER NEIL [US]; NEWMAN SHELDON [US]; LEE TAI YEON [US]; SCHRECK KATHLEEN [US]; BOWMAN CHRISTOPHER N [US]; BRACHO-TROCONIS CORA B [US]


Application No.: US20100304961A1  Published: 02/Dec/2010

Title: DENTAL CHEMICAL POLYMERIZATION CATALYST AND DENTAL CURABLE COMPOSITION CONTAINING THE SAME CATALYST

Applicant/Assignee: TOKUYAMA DENTAL CORPORATION

Application No.: 12/744791   Filing Date: 26/Nov/2008

Abstract:[Problems to be Solved] To provide a dental chemical polymerization catalyst comprising, particularly, a combination of an aryl borate compound and an acid compound, and exhibiting not only excellent polymerizing activity but also storage stability. [Means for Solution] A dental chemical polymerization catalyst comprising (A) an aryl borate compound

(B)an acid compound

(C) a vanadium compound having a valency of +IV or +V

and (D) a phenol type compound represented by the following general formula (1), wherein X1, X2 and X3 are each a hydrogen atom or a substitutent selected from the group consisting of a hydroxyl group, an alkoxy group and an alkyl group.

Priority: JP20070305858 Applic. Date: 2007-11-27; WO2008JP71447 Applic. Date: 2008-11-26

Inventor: KIMURA MIKIO [JP]; KAKIUCHI NAOKI [JP]


Application No.: US20100305062A1  Published: 02/Dec/2010

Title: USE OF ALGINATE OLIGOMERS IN COMBATING BIOFILMS

Applicant/Assignee: ALGIPHARMA IPR AS

Application No.: 12/745058   Filing Date: 24/Oct/2008

Abstract:The invention provides a method for combating biofilm, said method comprising contacting a biofilm with an alginate oligomer. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use in the treatment or prevention of a biofilm infection in a subject. In another aspect the method can be used to combat biofilms, on abiotic surfaces, e.g., for disinfection and cleaning purposes.

Priority: US20070996611P Applic. Date: 2007-11-27; WO2008GB03607 Applic. Date: 2008-10-24

Inventor: ONSOYEN EDVAR [NO]; MYRVOLD ROLF [NO]


Application No.: US20100305071A1  Published: 02/Dec/2010

Title: METHODS FOR IMPROVING HEALING OF AN ORAL LESION USING A GLYCEROPHOSPHATE SALT

Applicant/Assignee: PRELIEF INC

Application No.: 12/674773   Filing Date: 28/Aug/2008

Abstract:Glycerophosphate salts have been found to hasten the healing and rapid scaling of lesions of the mouth. Methods are provided for improving healing of an oral lesion or preventing diseases or conditions related to an oral lesion using a glycerophosphate salt. In particular, methods are provided for preventing diseases or conditions related to an oral lesion using calcium glycerophosphate (CGP).

Priority: US20070968928P Applic. Date: 2007-08-30; WO2008US74551 Applic. Date: 2008-08-28

Inventor: KLIGERMAN ALAN E [US]


Application No.: US20100305149A1  Published: 02/Dec/2010

Title: Polyal Drug Conjugates Comprising Variable Rate-Releasing Linkers

Applicant/Assignee: MERSANA THERAPEUTICS, INC

Application No.: 12/789047   Filing Date: 27/May/2010

Abstract:Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.

Priority: US20090181926P Applic. Date: 2009-05-28

Inventor: YURKOVETSKIY ALEKSANDR [US]; YIN MAO [US]; LIU GUI [US]; AKULLIAN LAURA C [US]; KANE JOHN J [US]; STEVENSON CHERI A [US]; HAMMOND CHARLES E [US]; PETTER RUSSELL C [US]; VAN DUZER JOHN H [US]; LOWINGER TIMOTHY B [US]


Application No.: US20100305233A1  Published: 02/Dec/2010

Title: Low stress flowable compositions

Applicant/Assignee:

Application No.: 12/587199   Filing Date: 02/Oct/2009

Abstract:A photopolymerizable and photocleavable (P&P) resin monomer is derived from a reactive photoresponsible moiety via various linkages to form photopolymerizable monomers and/or oligomers.

Priority: US2007-811264 Applic. Date: 2007-06-08; US20060812541P Applic. Date: 2006-06-09

Inventor: JIN XIAOMING [US]; HAMMESFAHR PAUL D [US]


Application No.: US20100305626A1  Published: 02/Dec/2010

Title: ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF

Applicant/Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Application No.: 12/864045   Filing Date: 13/Nov/2008

Abstract:Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more poly anions, and one of more multivalent cations. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

Priority: US20080023173P Applic. Date: 2008-01-24; WO2008US83311 Applic. Date: 2008-11-13

Inventor: STEWART RUSSELL JOHN [US]; SHAO HUI [US]


Application No.: US20100306893A1  Published: 09/Dec/2010

Title: PROTECTIVE FACE MASK

Applicant/Assignee: KREAPS APS

Application No.: 12/857052   Filing Date: 16/Aug/2010

Abstract:A protective face mask includes an eye-protecting shield made essentially from a plastics material. The eye-protecting shield is dimensioned to cover at least the eye portions of a human wearer. The eye-protecting shield has a perimeter defining a first surface facing the wearer's face, and a second surface facing away from the wearer's face. An adhesive forms an adhesive strip attached to the first surface of the eye-protecting shield for providing a substantially watertight and releasable sealing engagement between at least a portion of the perimeter forming an upper edge of the face mask and at least a portion of the skin of the wearer's face.

Priority: EP20060017965 Applic. Date: 2006-08-29; US2007-896127 Applic. Date: 2007-08-29; US20060840691P Applic. Date: 2006-08-29

Inventor: KAYEROED HELLE [DK]


Application No.: US20100307378A1  Published: 09/Dec/2010

Title: CARBAMATE-METHACRYLATE MONOMERS AND THEIR USE IN DENTAL APPLICATIONS

Applicant/Assignee: SEPTODONT CONFI-DENTAL DIVISION

Application No.: 12/756820   Filing Date: 08/Apr/2010

Abstract:The present invention relates, generally, to monomers containing carbamate-methacrylates or derivatives of carbamate-methacrylates, processes for making the monomers, and compositions comprising the monomers. The present invention also relates to methods of using the monomers, such as in dental applications, and in particular, dental restorative resins.

Priority: WO2009US60168 Applic. Date: 2009-10-09; US20080104139P Applic. Date: 2008-10-09

Inventor: TRUJILLO-LEMON MARIANELA [US]; WALL KRISTIN LINDSAY [US]; ESQUIBEL KRISTINA [US]; BOULDEN JORDAN [US]; DOCKTOR AMY J [US]; SHELTON ZACHARY R [US]; BRACHO-TROCONIS CORA [US]


Application No.: US20100308133A1  Published: 09/Dec/2010

Title: Rinsing Liquid Supplying Device

Applicant/Assignee:

Application No.: 12/477466   Filing Date: 03/Jun/2009

Abstract:A rinsing liquid supplying device includes a bottle for storing rinsing liquid, a liquid outlet unit, and a locking collar formed with a collar opening. The bottle includes a mouth section. The liquid outlet unit includes a hollow fixing section, a spraying section formed with a spray hole unit, and an intermediate duct section disposed between and in fluid communication with the fixing section and the spraying section. The fixing section has an annular lip disposed to abut against the mouth section of the bottle, and a liquid guide interconnecting the annular lip and the intermediate duct section. The locking collar is adapted for engaging the mouth section. The liquid guide extends through the locking collar, and the annular lip is clamped between the locking collar and the mouth section to retain the liquid outlet unit on the bottle when the locking collar engages the mouth section.

Priority:

Inventor: YEH CHIN-CHUN [TW]


Application No.: US20100309302A1  Published: 09/Dec/2010

Title: Apparatus and a System for Visualizing Teeth Cleaning

Applicant/Assignee:

Application No.: 12/794710   Filing Date: 04/Jun/2010

Abstract:A system includes an apparatus having a head having a removable cap having a tool configured for cleaning activities within a mouth. A handle is joined to the head for enabling the head to be manipulated within the mouth. An image sensor having a lens is at least partially disposed on the head for capturing images within the mouth. An illumination source is disposed on the head for illuminating objects to assist the image sensor in capturing the images. A transmitter conveys the images. A receiver receives the conveyed images. A display is connected to the receiver for displaying the conveyed images thereby assisting a user in the cleaning activities.

Priority: US20090185202P Applic. Date: 2009-06-09

Inventor: YANG JIANDONG [US]


Application No.: US20100310463A1  Published: 09/Dec/2010

Title: Anti-EpCAM Antibodies

Applicant/Assignee: AFFITECH RESEARCH AS

Application No.: 12/797052   Filing Date: 09/Jun/2010

Abstract:Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided.

Priority: GB20090009904 Applic. Date: 2009-06-09; US20090185387P Applic. Date: 2009-06-09

Inventor: CICORTAS GUNNARSSON LAVINIA DIANA [NO]; PAUS DIDRIK [NO]; KARLSSON JENNY MARGARETA [NO]; GRIEP REMKO ALBERT [NO]; KIPRIJANOV SERGEJ MICHAILOVIC [NO]


Application No.: US20100310476A1  Published: 09/Dec/2010

Title: CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF

Applicant/Assignee: FOAMIX LTD

Application No.: 12/795164   Filing Date: 07/Jun/2010

Abstract:The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.

Priority: WO2008IB03932 Applic. Date: 2008-12-08; US20070012414P Applic. Date: 2007-12-07; US20080103500P Applic. Date: 2008-10-07

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]; SHIFRIN HELENA [IL]


Application No.: US20100310478A1  Published: 09/Dec/2010

Title: SUBSTITUTED BENZOQUINONES AND HYDROQUINONES IN THE TREATMENT OF PERIODONTAL DISEASES

Applicant/Assignee:

Application No.: 12/747480   Filing Date: 11/Dec/2008

Abstract:An alkyl- or halo-substituted benzoquinone, hydroquinone or mixture thereof, for use in the treatment of a periodontal disease, and/or for use in the treatment of a condition which is caused by, transmitted by or exacerbated by P. gingivalis or by biofilm formation by P. gingivalis.

Priority: GB20070024278 Applic. Date: 2007-12-13; WO2008GB04071 Applic. Date: 2008-12-11

Inventor: FITZGERALD DANIEL JAMES [GB]; READ NICHOLAS EDWARD [GB]; GOTTARDELLO PRISCILA [GB]; JONES STEPHEN PHILIP [GB]


Application No.: US20100310614A1  Published: 09/Dec/2010

Title: Stannous Chloride Compositions

Applicant/Assignee:

Application No.: 12/480236   Filing Date: 08/Jun/2009

Abstract:The invention relates to a particulate composition comprising: c) a particulate source of stannous chloride

d) and silicon dioxide (also referred to as hydrated silica or silica). The invention further relates to a method for improving the flowability of particulate stannous chloride by admixing silica with it. The composition of the invention has been found to give improved flow properties to stannous chloride when compared to the absence of an anti-caking agent, as assessed via methods of powder characterisation detailed in the European Pharmacopoeia.

Priority:

Inventor: STRAND ROSS [GB]; THURLBY OWEN [GB]


Application No.: US20100310677A1  Published: 09/Dec/2010

Title: STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING PHOSPHORYLATED AMINO ACIDS

Applicant/Assignee: AMORPHICAL LTD

Application No.: 12/739071   Filing Date: 22/Oct/2008

Abstract:Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.

Priority: IL20070186850 Applic. Date: 2007-10-22; IL20080193461 Applic. Date: 2008-08-14; WO2008IL01362 Applic. Date: 2008-10-22

Inventor: BENTOV SHMUEL [IL]; SAGI AMIR [IL]; BERMAN AMIR [IL]; SHECHTER ASSAF [IL]


Application No.: US20100310679A1  Published: 09/Dec/2010

Title: NOVEL COMPOSITIONS FOR CONTROL OF MALICIOUS MARINE ANEMONES

Applicant/Assignee:

Application No.: 12/812743   Filing Date: 31/Dec/2008

Abstract:The present invention relates to improved compositions for controlling marine pest anemones, to methods of application of same, and to kits for the convenient dispensing of such compositions.

Priority: IL20080188817 Applic. Date: 2008-01-16; WO2008IL01702 Applic. Date: 2008-12-31

Inventor: RAM SHARON [IL]


Application No.: US20100310684A1  Published: 09/Dec/2010

Title: METHODS FOR TREATING AND PREVENTING MUCOSITIS

Applicant/Assignee: INDENA S.P.A

Application No.: 12/856786   Filing Date: 16/Aug/2010

Abstract:Methods for treating and preventing mucositis, in particular mucositis following the administration of chemotherapy drugs or a combination of said drugs with radiotherapy, are disclosed herein. More specifically, disclosed herein is the administration of a therapeutically effective amount of at least one of an anthocyanoside, a proanthocyanidin, or an extract containing at least one of an anthocyanoside or a proanthocyanidin for the treatment or prevention of mucositis. The therapeutically effective amount of the anthocyanoside, proanthocyanidin or extract can be administered alone or in combination with a therapeutically effective amount of at least one of an anti-inflammatory agent, immunomodulating agent, analgesic, antimicrobial agent or antifungal agent. Also disclosed herein are pharmaceutical compositions for treating and preventing mucositis.

Priority: EP20060015732 Applic. Date: 2006-07-28; US2007-829138 Applic. Date: 2007-07-27

Inventor: BOMBARDELLI EZIO [IT]; MORAZZONI PAOLO [IT]


Application No.: US20100310729A1  Published: 09/Dec/2010

Title: Packaged Beverage Having Enhanced Carbon Dioxide Retention, Method For Packaging A Beverage, Container For Packaging A Beverage, And Polyester Composition

Applicant/Assignee: THE COCA-COLA COMPANY

Application No.: 12/857958   Filing Date: 17/Aug/2010

Abstract:A packaged aqueous carbonated beverage comprising a container which replaces at least a portion of CO2 that permeates through the container or closure. The container comprises a polyester composition including a polyester suitable for packaging aqueous carbonated beverages and a carbonating agent. The aqueous carbonated beverage is disposed in the container such that the aqueous carbonated beverage has direct contact with the container and a closure seals the beverage in the container. The carbonating agent reacts with water in the carbonated beverage forming CO2 for replacing at least a portion of CO2 that permeates through the container or closure. A corresponding method of packaging an aqueous carbonated beverage is disclosed.

Priority: US2005-068483 Applic. Date: 2005-02-28; US20040549318P Applic. Date: 2004-03-02

Inventor: SHI YU [US]


Application No.: US20100311007A1  Published: 09/Dec/2010

Title: Gingival massaging device

Applicant/Assignee:

Application No.: 12/803421   Filing Date: 28/Jun/2010

Abstract:A gingival massaging device comprising a dental arch shaped body for positioning within the oral cavity between the gingiva and the tissue linings of the lips, and the teeth, wherein the body comprises an internal track along which a plurality of massaging elements for massaging the gingiva are movable, wherein adjacent massaging elements are connected to each other by a mechanical linkage, wherein the device further comprises a shifting mechanism for moving the massaging elements along the track.

Priority: IL20070187291 Applic. Date: 2007-11-11; WO2008IL01471 Applic. Date: 2008-11-09

Inventor: ELIYAHOV AVRAHAM [IL]


Application No.: US20100311699A1  Published: 09/Dec/2010

Title: NOVEL CARBOXYLIC ACID 4-PHENYLAZO-PHENYL ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/745530   Filing Date: 27/Nov/2008

Abstract:This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20070001715 Applic. Date: 2007-11-30; WO2008EP66296 Applic. Date: 2008-11-27

Inventor: PETERS DAN [SE]; REDROBE JOHN PAUL [DK]; NIELSEN ELSEBET OESTERGAARD [DK]


Application No.: US20100311746A1  Published: 09/Dec/2010

Title: MODULATORS OF MUSCARINIC RECEPTORS

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/794202   Filing Date: 04/Jun/2010

Abstract:The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Priority: US2006-359960 Applic. Date: 2006-02-22; US2005-208386 Applic. Date: 2005-08-19; US20040602731P Applic. Date: 2004-08-19

Inventor: MAKINGS LEWIS R [US]; BLANCO MIGUEL GARCIA-GUZMAN [US]; HURLEY DENNIS J [US]; DRUTU IOANA [US]; RAFFAI GABRIEL [US]; BERGERON DANIELE M [US]; NAKATANI AKIKO [US]; TERMIN ANDREAS P [US]; SILINA ALINA [US]


Application No.: US20100311778A1  Published: 09/Dec/2010

Title: CHROMANE DERIVATIVES AS TRPV3 MODULATORS

Applicant/Assignee:

Application No.: 12/808937   Filing Date: 16/Dec/2008

Abstract:The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

Priority: IN2007MU02481 Applic. Date: 2007-12-18; IN2008MU00647 Applic. Date: 2008-03-26; US20080019995P Applic. Date: 2008-01-09; US20080043931P Applic. Date: 2008-04-10; WO2008IN00838 Applic. Date: 2008-12-16

Inventor: LINGAM V S PRASADARAO [IN]; THOMAS ABRAHAM [IN]; GHARAT LAXMIKANT ATMARAM [IN]; UKIRDE DEEPAK VITTHAL [IN]; PHATANGARE SHANTARAM KASHINATH [IN]; MINDHE AJIT SHANKAR [IN]; KHAIRATKAR-JOSHI NEELIMA [IN]; KATTIGE VIDYA GANAPATI [IN]


Application No.: US20100311809A1  Published: 09/Dec/2010

Title: VIRAL VECTOR SYSTEM, A COMPOSITION COMPRISING THE VIRAL VECTOR SYSTEM AND ITS USE

Applicant/Assignee: CHARITE UNIVERSITAETSMEDIZIN BERLIN

Application No.: 12/680425   Filing Date: 27/Oct/2008

Abstract:The present invention relates to a viral vector system comprising at least one viral vector and at least one regulable expression cassette inserted in said viral vector applicable for the treatment of virally infected cells. Preferably, the at least one regulable expression cassette comprises at least one transactivator, at least one promoter and at least one nucleotide sequence coding for a transgene, preferably a fusion protein. The present invention also relates to a composition comprising said viral vector and antiviral siRNAs for treatment of virally infected cells.

Priority: DE200710052005 Applic. Date: 2007-10-26; WO2008EP09058 Applic. Date: 2008-10-27

Inventor: FECHNER HENRY [DE]; PINKERT SANDRA [DE]; KURRECK JENS [DE]; WERK DENISE [DE]


Application No.: US20100311830A1  Published: 09/Dec/2010

Title: Menthol Replacement

Applicant/Assignee: GIVAUDAN S.A

Application No.: 12/783607   Filing Date: 20/May/2010

Abstract:A method of producing in a composition adapted to be applied to the mucous membranes, the physiological effects of menthol at a reduced menthol concentration, by the partial replacement of menthol by a cooling and flavour blend, including (a) at least one compound selected from the group consisting of lactoyl ethanolamide, nonanoic acid vanillyl amide and menthyl lactate

and (b) at least one compound of the Formula I in which the dotted line represents an optional single bond, the moieties R1, R2, R3, R4 and R5 being independently selected from H, CH3 and OH, three moieties being H, one CH3 and one OH, such that (i) when the optional single bond is absent, one of R1 and R5 is OH only when R3 is H

and (ii) when the optional single bond is present, R3 is CH3 and one of R1 and R5 is OH.

Priority: US20090179919P Applic. Date: 2009-05-20

Inventor: DE JONGE MARCO [NL]; WINKEL CORNELIS [NL]; MACHOVER SARAH BARRIE [US]; FURRER STEFAN MICHAEL [US]; TONDEUR ALEXANDER P [NL]


Application No.: US20100311833A1  Published: 09/Dec/2010

Title: Physiological coolants based on lactoyl esters of menthyl lactate

Applicant/Assignee:

Application No.: 12/806337   Filing Date: 10/Aug/2010

Abstract:A method of imparting a physiological cooling effect to a consumer product is disclosed. The method comprises formulating into the consumer product a composition comprising at least one lactoyl ester of menthyl lactate. Also disclosed is a method of providing physiological cooling by contacting skin or mucous membranes with the lactoyl ester compositions. Coolants comprising the lactoyl esters and additional coolants are also disclosed. The lactoyl esters are conveniently prepared from menthol and lactic acid.

Priority: US2007-974575 Applic. Date: 2007-10-15

Inventor: ERMAN MARK B [US]; WHELAN PATRICK J [US]; SNOW JOE W [US]


Application No.: US20100311858A1  Published: 09/Dec/2010

Title: DENTAL COMPOSITIONS AND INITIATOR SYSTEMS WITH COLOR-STABLE AMINE ELECTRON DONORS

Applicant/Assignee:

Application No.: 12/740466   Filing Date: 29/Oct/2008

Abstract:The invention features a hardenable dental composition, e.g., polymerizable dental restoratives, adhesives, etc., that contain a color-stable amine electron donor in an initiation system for initiating polymerization of the composition.

Priority: US20070984470P Applic. Date: 2007-11-01; WO2008US81559 Applic. Date: 2008-10-29

Inventor: HOLMES BRIAN N [US]; KOBUSSEN GREGORY A [US]


Application No.: US20100312198A1  Published: 09/Dec/2010

Title: INSERT FOR TREATING HUMAN OR ANIMAL BODY CAVITIES, IN PARTICULAR EAR CAVITIES

Applicant/Assignee:

Application No.: 12/445965   Filing Date: 19/Oct/2007

Abstract:An insert (1) for treating human or animal body cavities, in particular ear cavities, comprises an operating element (2) which is located at one end of the insert intended to be introduced into the cavity and to come into contact with the internal walls of the latter, and is expandable from a radially compressed configuration, in which it may be introduced into the cavity without substantial interference with the internal walls, to a radially expanded configuration having a substantially larger cross-section relative to the compressed configuration, in which radially expanded configuration the operating element (2) is pressed against the internal walls of the cavity.

Priority: IT2006PD00389 Applic. Date: 2006-10-20; WO2007IT00732 Applic. Date: 2007-10-19

Inventor: GUIDI GIANMARIA [IT]


Application No.: US20100312722A1  Published: 09/Dec/2010

Title: Privately Provisioned Sub-Unit-Based Survival Supplies Provisioning Method

Applicant/Assignee:

Application No.: 11/532461   Filing Date: 15/Sep/2006

Abstract:A private civil security subscription mechanism serves to facilitate the provision of survival supplies for corresponding authorized beneficiaries. These supplies are segregated into sub-units dedicated to like supplies such that one sub-unit includes supplies of a particular category of supply. The sub-units may be differentiated such that within each category of supply are available different kinds of supplies. The sub-units of supplies can be fully or partially formed into a unit of supplies or can remain separate sub-units. If desired, an additional amount of supplies can be added to the unit if requested by the authorized beneficiary.

Priority: US2006-384037 Applic. Date: 2006-03-17; US2006-394350 Applic. Date: 2006-03-30; US2006-279333 Applic. Date: 2006-04-11; US2006-379929 Applic. Date: 2006-04-24; US2006-381247 Applic. Date: 2006-05-02; US2006-381257 Applic. Date: 2006-05-02; US2006-381265 Applic. Date: 2006-05-02; US2006-381277 Applic. Date: 2006-05-02; US2006-383022 Applic. Date: 2006-05-12; US2006-420594 Applic. Date: 2006-05-26; US2006-421694 Applic. Date: 2006-06-01; US2006-423594 Applic. Date: 2006-06-12; US2006-425043 Applic. Date: 2006-06-19; US2006-426231 Applic. Date: 2006-06-23; US2006-456472 Applic. Date: 2006-07-10; US2006-461605 Applic. Date: 2006-08-01; US2006-461624 Applic. Date: 2006-08-01; US2006-462795 Applic. Date: 2006-08-07; US2006-462845 Applic. Date: 2006-08-07; US2006-464751 Applic. Date: 2006-08-15; US2006-464764 Applic. Date: 2006-08-15; US2006-464775 Applic. Date: 2006-08-15; US2006-464788 Applic. Date: 2006-08-15; US2006-464799 Applic. Date: 2006-08-15; US2006-465063 Applic. Date: 2006-08-16; US2006-466727 Applic. Date: 2006-08-23; US2006-466953 Applic. Date: 2006-08-24; US2006-470156 Applic. Date: 2006-09-05; US2006-531651 Applic. Date: 2006-09-13

Inventor: MOORE BARRETT H [US]


Application No.: US20100315303A1  Published: 16/Dec/2010

Title: Folded slotted monopole antenna

Applicant/Assignee: TDK CORPORATION

Application No.: 12/457434   Filing Date: 10/Jun/2009

Abstract:A slotted monopole wideband antenna, comprising an insulating rectangular chip mounted on a carrier substrate, said carrier substrate including a feeding structure, and said chip comprising a first side adjacent to said feeding structure, a feed point of the antenna is located near said first side. An electrically conducting lamina is folded over four faces of said insulating chip, said lamina being connected to the feed point at one end, and to ground at another end. At least two slots are formed in an upper section of said folded lamina, said slots having the effect of lowering the principal resonance of said antenna, thereby providing a miniaturized antenna suitable for integration in a mobile wireless communications handset.

Priority:

Inventor: KEARNEY DAVID [IE]; MODRO JOSEPH [IE]


Application No.: US20100316434A1  Published: 16/Dec/2010

Title: OVER CAP BRUSH FOR DISPENSING BOTTLE

Applicant/Assignee: TABLECRAFT PRODUCTS COMPANY

Application No.: 12/484277   Filing Date: 15/Jun/2009

Abstract:An over cap brush for a squeeze dispensing bottle comprising a body injection molded as a single piece, the body being formed of a relatively soft elastomeric material, the body including a circular end wall, a generally cylindrical skirt at an outer periphery of the end wall defining a central axis and extending in one direction along the axis, the end wall having a central through hole and an outer face with a multitude of bristles distributed about the hole and extending axially from said face in a direction opposite the one direction, the skirt being of sufficient length so as to extend along the threads of a screw-on cap to retain the over cap brush on the cap by frictionally engaging the exterior of the skirt of the cap while the cap is disposed on a squeeze dispensing bottle.

Priority:

Inventor: MAXWELL CHARLES P [US]


Application No.: US20100316579A1  Published: 16/Dec/2010

Title: NOVEL USE OF ALKYL PHOSPHATE ESTERS

Applicant/Assignee: GLAXO GROUP LIMITED

Application No.: 12/446086   Filing Date: 25/Oct/2007

Abstract:The use of an oral care composition comprising certain alkyl phosphates is described for combating dental erosion and tooth wear.

Priority: GB20060021329 Applic. Date: 2006-10-26; WO2007EP61461 Applic. Date: 2007-10-25

Inventor: FOWLER CHRISTABEL [GB]; REES GARETH DAVID [GB]


Application No.: US20100316580A1  Published: 16/Dec/2010

Title: ORAL CARE PRODUCT AND METHODS OF USE THEREOF

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866655   Filing Date: 06/Feb/2009

Abstract:This invention relates to oral care compositions comprising an effective amount of a basic amino acid in free or salt form and a low dosage of fluoride and to methods of using such compositions.

Priority: US20080027431P Applic. Date: 2008-02-08; US20080027420P Applic. Date: 2008-02-08; US20080027432P Applic. Date: 2008-02-08; US20080027435P Applic. Date: 2008-02-08; US20080027441P Applic. Date: 2008-02-09; US20080027442P Applic. Date: 2008-02-09; WO2009US33290 Applic. Date: 2009-02-06

Inventor: KOHLI RAJNISH [US]; ROBINSON RICHARD SCOTT [US]; SULLIVAN RICHARD J [US]; COMMINS DIANE [US]


Application No.: US20100316685A1  Published: 16/Dec/2010

Title: Dental Uses of Silver Hydrosol

Applicant/Assignee: AMERICAN BIOTECH LABS, LLC

Application No.: 12/482359   Filing Date: 10/Jun/2009

Abstract:Microbiologically effective silver hydrosol is used to reduce the local level of microorganisms at the site of a dental procedure and to prevent or inhibit their growth during the healing that follows the procedure. Any gingival lesions created by a dental procedure are treated with silver hydrosol in an aqueous gel. Following the procedure the patient's mouth is periodically rinsed several times a day with a solution of silver hydrosol or, more preferably, with a combination of silver hydrosol and hydrogen peroxide. These steps result in a significant reduction in post operative pain and swelling. Overall healing is accelerated by this treatment.

Priority:

Inventor: WILLOUGHBY ANDREW J M [CA]


Application No.: US20100316726A1  Published: 16/Dec/2010

Title: TOOTH SEALANT

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866766   Filing Date: 06/Feb/2009

Abstract:The invention provides a method of treating sensitive teeth comprising attaching a sealant composition comprising a basic amino acid to a person's tooth and allowing the basic amino acid to be slowly released over time in order to reduce chrome and/or acute tooth sensitivity together with compositions and methods of use.

Priority: US20080027425P Applic. Date: 2008-02-08; WO2009US33312 Applic. Date: 2009-02-06

Inventor: PRENCIPE MICHAEL [US]; ROBINSON BELLE MEAD SCOTT [US]; KOHLI RAJNISH [US]; SULLIVAN RICHARD J [US]


Application No.: US20100317676A1  Published: 16/Dec/2010

Title: Fused heterocyclic compounds, and compositions and uses thereof

Applicant/Assignee: RENOVIS, INC

Application No.: 12/660588   Filing Date: 01/Mar/2010

Abstract:Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4', Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Priority: US2006-429026 Applic. Date: 2006-05-04; US20050677760P Applic. Date: 2005-05-04

Inventor: KELLY MICHAEL G [US]; KINCAID JOHN [US]; KAUB CARL J [US]


Application No.: US20100317723A1  Published: 16/Dec/2010

Title: Nucleolin Specific Aptamer and Use thereof

Applicant/Assignee: POSTECH ACADEMY-INDUSTRY FOUDATION POSCO

Application No.: 12/759813   Filing Date: 14/Apr/2010

Abstract:Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.

Priority: US20090169348P Applic. Date: 2009-04-15

Inventor: LEE JUNG-HWAN [KR]; KIM SOON-HAG [KR]; KWON MI-JIN [KR]; KANG HYUN-GU [KR]; RYU SUNG-HO [KR]; KIM JONG-IN [KR]; KIM YOUN-DONG [KR]; CHAE YOUNG-CHAN [KR]; JANG SUNG-KEY [KR]; IM JONG-HUN [KR]; LEE SUN-HAK [KR]; LEE HYE-JUNG [KR]; JANG EUN-JUNG [KR]; KIM KI-SEOK [KR]


Application No.: US20100317730A1  Published: 16/Dec/2010

Title: Treatment for menopausal and perimenopausal vasomotor symptons

Applicant/Assignee:

Application No.: 12/802651   Filing Date: 11/Jun/2010

Abstract:Disclosed is a medicinal composition and method of use comprising topiramate for treating hot flashes and excessive sweating known as vasomotor symptoms related to perimenopausal or menopausal symptoms and in a still further embodiment of the invention topiramate and the medicine for treating menopause and perimenopause are provided in a kit or in unit dosage form, e.g., tablet or capsule. As a further embodiment of this invention, topiramate may be administered along with a medicament use to treat hot flashes and excessive sweating related to perimenopausal or menopausal symptoms.

Priority: US20090186535P Applic. Date: 2009-06-12

Inventor: SHAYA ELIAS K [US]


Application No.: US20100317734A1  Published: 16/Dec/2010

Title: FREE FATTY ACID BLENDS AND USE THEREOF

Applicant/Assignee:

Application No.: 12/734929   Filing Date: 04/Dec/2008

Abstract:An antimicrobial composition comprising a blend of two or more natural free fatty acids derivable from milk serum lipid, the free fatty acids being selected from: butyric (C4)

caproic (C6)

caprylic (C8)

capric (C10)

lauric (C12)

myristic (C14)

palmitic (C 16): palmitoleic 5 (C16:1)

stearic (C1 8)

oleic (C18:1)

linoleic (Cl 8:2)

linolenic (C18:3)

and esterified derivatives thereof, and a milk, protein as an emulsifying agent for the free fatty acids wherein at least 35% of the total lipid content comprises free fatty acids selected from one or more of: butyric, caproic, caprylic, capric and lauric.

Priority: IE20080000819 Applic. Date: 2008-10-09; US20070996754P Applic. Date: 2007-12-04; WO2008IE00118 Applic. Date: 2008-12-04

Inventor: FOLAN MICHAEL ANTHONY [IE]; O'BRIEN COLM [IE]; DUNNE COLUM [IE]


Application No.: US20100317762A1  Published: 16/Dec/2010

Title: ADHESIVE COMPOSITION FOR DENTAL USE

Applicant/Assignee: TOKUYAMA DENTAL CORPORATION

Application No.: 12/526070   Filing Date: 08/Nov/2007

Abstract:An adhesive composition for dental use exhibiting acidic property, including a mixture of a polymerizable monomer component (A) containing a phosphoric acid-type polymerizable monomer having an acidic group derived from phosphoric acid, and a multivalent metal ion-releasing component (B), wherein the multivalent metal ion-releasing component (B) is capable of releasing at least earth metal ions, and in the composition, earth metal ions stemming from the component (B) are present together with the phosphoric acid-type polymerizable monomer in such an amount that a total valency ratio (RE) defined by the following formula (1) is in a range of 0.2 to 3.0. The adhesive composition is capable of strongly adhering and fixing a composite resin or a prosthetic material to a tooth for extended periods of time maintaining stability. RE=TVE/TVA (1) wherein TVE is a total valency of the earth metal ions contained in said composition, and TVA is a total valency of the acidic groups of the phosphoric acid-type polymerizable monomer contained in said composition.

Priority: JP20070038059 Applic. Date: 2007-02-19; JP20070040031 Applic. Date: 2007-02-20; WO2007JP72145 Applic. Date: 2007-11-08

Inventor: MATSUSHIGE KOJI [JP]; SUZUKI TAKESHI [JP]; SHIMIZU SHIZUKA [JP]; DODOMI AYUMI [JP]


Application No.: US20100318232A1  Published: 16/Dec/2010

Title: METHOD FOR EVALUATING A PARTICLE SIGNAL AND SUCTION NOZZLE FOR A VACUUM CLEANER

Applicant/Assignee: MIELE & CIE. KG

Application No.: 12/808775   Filing Date: 11/Dec/2008

Abstract:A method for evaluating a particle signal with an evaluation unit associated with a control device includes generating a particle signal by a sensor within a flow element, the particular sensor being dependent on a number of particles in a two-phase flow generated when cleaning a surface by a suction device connected to the flow control element. The method further includes determining in the evaluation unit from the particle signal a control signal for further controlling an actuator controlled by the control device. A speed of movement of the flow element over the surface is taken into account in the determination of the control signal.

Priority: DE200710061146 Applic. Date: 2007-12-17; WO2008EP10515 Applic. Date: 2008-12-11

Inventor: TIEKOETTER STEFAN [DE]; WOLF CORNELIUS [DE]


Application No.: US20100319711A1  Published: 23/Dec/2010

Title: AIRWAY IMPLANT AND METHODS OF MAKING AND USING

Applicant/Assignee: PAVAD MEDICAL, INC

Application No.: 12/821912   Filing Date: 23/Jun/2010

Abstract:A system and device for maintaining and/or creating patency in airways is disclosed. The methods of using the system and device are also disclosed. The system includes a power source that energizes a electro-active polymer implant. The energized polymer implant provides stiffness and shape to the airway, thereby minimizing collapse or deformation of the airway. A method of making the device is also disclosed.

Priority: US2004-946435 Applic. Date: 2004-09-21

Inventor: HEGDE ANANT V [US]; CHOI GEORGE S [US]; BUCH WALLY S [US]


Application No.: US20100322872A1  Published: 23/Dec/2010

Title: NOVEL METHODS AND MEDICAMENT FOR TREATING INFECTIOUS DISEASES INVOLVING MICROBIAL BIOFILMS

Applicant/Assignee:

Application No.: 12/849288   Filing Date: 03/Aug/2010

Abstract:The present invention provides a method for prophylaxis and therapy of infectious diseases caused by microorganisms present in biofilms adherent to cell surfaces comprising the step of administering to an individual in need thereof a composition comprising a combination of at least one compound chosen from the group of peroxidase, lactoferrin, lactoferrin peptides, lysozyme and immunoglobulins and at least one growth factor.

Priority: EP19990870145 Applic. Date: 1999-07-07; US2006-480676 Applic. Date: 2006-07-03; US2002-048708 Applic. Date: 2002-04-05; WO2000EP06312 Applic. Date: 2000-07-05

Inventor: PERRAUDIN JEAN-PAUL [BE]


Application No.: US20100322873A1  Published: 23/Dec/2010

Title: BEVERAGE COMPRISING ARGININE

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866760   Filing Date: 06/Feb/2009

Abstract:The invention provides a beverage comprising a basic amino acid and a calcium salt.

Priority: US20080027434P Applic. Date: 2008-02-08; WO2009US33307 Applic. Date: 2009-02-06

Inventor: KOHLI RAJNISH [US]; ROBINSON RICHARD SCOTT [US]; CUMMINS DIANE [US]; JAYARAMAN NAGARAJA [US]


Application No.: US20100322985A1  Published: 23/Dec/2010

Title: EFFERVESCENT COMPOSITIONS

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866609   Filing Date: 06/Feb/2009

Abstract:The present invention is directed to effervescent compositions comprising a basic amino acid.

Priority: US20080027430P Applic. Date: 2008-02-08; WO2009US33299 Applic. Date: 2009-02-06

Inventor: KOHLI RAJNISH [US]; ROBINSON RICHARD SCOTT [US]; SANTARPIA RALPH PETER [US]; BROWN JAMES R [US]; SULLIVAN RICHARD J [US]; PRENCIPE MICHAEL [US]


Application No.: US20100322986A1  Published: 23/Dec/2010

Title: COMPOSITIONS AND DEVICES

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866624   Filing Date: 06/Feb/2009

Abstract:The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments.

Priority: US20080027428P Applic. Date: 2008-02-08; WO2009US33303 Applic. Date: 2009-02-06

Inventor: PRENCIPE MICHAEL [US]; ROBINSON RICHARD SCOTT [US]; KOHLI RAJNISH [US]; SULLIVAN RICHARD J [US]; CUMMINS DIANE [US]


Application No.: US20100322987A1  Published: 23/Dec/2010

Title: DENTAL WIPE

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866764   Filing Date: 06/Feb/2009

Abstract:The present invention is directed to a dental wipe comprising a basic amino acid or salt thereof.

Priority: US20080027426P Applic. Date: 2008-02-08; WO2009US33297 Applic. Date: 2009-02-06

Inventor: ROBINSON RICHARD SCOTT [US]; SULLIVAN RICHARD J [US]; CUMMINS DIANE [US]


Application No.: US20100322988A1  Published: 23/Dec/2010

Title: COMPOSITIONS AND DEVICES

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866780   Filing Date: 06/Feb/2009

Abstract:The present invention provides tooth-whitening compositions comprising a bleaching agent and a baste amino acid, together with devices for application thereof, and methods of use therefor.

Priority: US20080027429P Applic. Date: 2008-02-08; WO2009US33306 Applic. Date: 2009-02-06

Inventor: PRENCIPE MICHAEL [US]; ROBINSON RICHARD SCOTT [US]; KOHLI RAJNISH [US]; SULLIVAN RICHARD J [US]


Application No.: US20100323013A1  Published: 23/Dec/2010

Title: HYDROLYSATES MADE OF PLANT EXTRACTS AND ANTIBACTERIAL AGENT CONTAINING THE SAME

Applicant/Assignee: BIONORICA SE

Application No.: 12/740396   Filing Date: 30/Oct/2008

Abstract:The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.

and a mixture thereof

or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba

and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.

Priority: DE200710052223 Applic. Date: 2007-10-31; WO2008EP09171 Applic. Date: 2008-10-30

Inventor: BONN GUENTHER [AT]; STECHER GUENTHER [AT]; POPP MICHAEL A [DE]; MAYER ROBERT [AT]


Application No.: US20100323022A1  Published: 23/Dec/2010

Title: CALCIUM PHOSPHATE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/866689   Filing Date: 05/Feb/2009

Abstract:A calcium phosphate composition comprising calcium phosphate particles (A) and a sulfonic acid salt (B), wherein the calcium phosphate composition contains 0.5 to 20 parts by weight of the sulfonic acid salt (B) based on 100 parts by weight of the calcium phosphate particles (A). This provides a calcium phosphate composition that has a time between the addition of a liquid agent to the calcium phosphate composition and the completion of setting in the use at a clinical site and the like, i.e., a setting time which is within an appropriate range and that is high in mechanical strength and good in marginal sealing ability.

Priority: JP20080027827 Applic. Date: 2008-02-07; WO2009JP51949 Applic. Date: 2009-02-05

Inventor: HASHIMOTO TADASHI [JP]; OKADA KOICHI [JP]


Application No.: US20100323322A1  Published: 23/Dec/2010

Title: Syringe-in-Syringe Hollow Inner Barrel/Plunger With Integral Seal and Rupturable Membrane and Related Kits, Systems and Methods

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/525961   Filing Date: 26/Apr/2007

Abstract:A hollow inner plunger (100) for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall (102) defining an internal chamber (108) for containing a first component (HOa). The body (100) includes a proximal end (104) and a distal end (106). A sealing plug and rupturable membrane (116) are disposed at the distal end of the body, and the sealing plug and rupturable membrane (116) are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system (124) includes a first plunger (126), the hollow inner plunger (100), and a syringe barrel (128) configured to contain a second component (HOb). When assembled, the first plunger (126) is slidably disposed within the hollow inner plunger (100), and the hollow inner plunger (100) is slidably disposed within the syringe barrel (128). The two components (110a, 110b) are initially separated by the rupturable membrane (116).

Priority: US2007-673334 Applic. Date: 2007-02-09; WO2007US67556 Applic. Date: 2007-04-26

Inventor: JESSOP NEIL [US]; MCLEAN BRUCE S [US]; SHEETZ JARED [US]


Application No.: US20100323323A1  Published: 23/Dec/2010

Title: Pliable gingival isolation material

Applicant/Assignee: CAO GROUP, INC

Application No.: 11/473384   Filing Date: 22/Jun/2006

Abstract:A gingival isolation material that is pliable once cured or set. The isolation material can include components such as water, a thickening agent, a plasticizer, a dye and a preservative.

Priority: US20050693971P Applic. Date: 2005-06-24

Inventor: LARSEN ROBERT K [US]


Application No.: US20100323330A1  Published: 23/Dec/2010

Title: Tooth Colorant and Whitener, Method of Manufacture, and Method of Use Thereof

Applicant/Assignee: PENTRON CLINICAL TECHNOLOGIES LLC

Application No.: 12/869087   Filing Date: 26/Aug/2010

Abstract:A polymerizable tooth colorant composition, comprising: a polymerizable resin composition

an additive composition comprising a colorant, a whitener, or both

and a curing system. The composition allows easy coloring and/or whitening of teeth.

Priority: US2005-289764 Applic. Date: 2005-11-29

Inventor: JIA WEITAO [US]


Application No.: US20100324027A1  Published: 23/Dec/2010

Title: DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/818764   Filing Date: 18/Jun/2010

Abstract:The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.

Priority: US20090218479P Applic. Date: 2009-06-19

Inventor: SCHRIMPF MICHAEL R [US]; SIPPY KEVIN B [US]


Application No.: US20100324056A1  Published: 23/Dec/2010

Title: BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Applicant/Assignee:

Application No.: 12/820577   Filing Date: 22/Jun/2010

Abstract:Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Priority: US20090219016P Applic. Date: 2009-06-22

Inventor: BROKA CHRIS ALLEN [US]; HAWLEY RONALD CHARLES [US]


Application No.: US20100324069A1  Published: 23/Dec/2010

Title: OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Applicant/Assignee:

Application No.: 12/820660   Filing Date: 22/Jun/2010

Abstract:Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Priority: US20090219022P Applic. Date: 2009-06-22

Inventor: CHEN LI [CN]; DILLON MICHAEL PATRICK [US]; FENG LICHUN [CN]; YANG MINMIN [CN]


Application No.: US20100324070A1  Published: 23/Dec/2010

Title: INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Applicant/Assignee:

Application No.: 12/820748   Filing Date: 22/Jun/2010

Abstract:Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Priority: US20090219177P Applic. Date: 2009-06-22

Inventor: DILLON MICHAEL PATRICK [US]; KRAUSS NANCY ELISABETH [US]


Application No.: US20100324110A1  Published: 23/Dec/2010

Title: Self Solidifying Bioerodible Barrier Implant

Applicant/Assignee: TRILOGIC PHARMA LLC

Application No.: 12/740548   Filing Date: 02/Dec/2008

Abstract:Provided are bioerodible compositions that can be implanted into cavities of mammalian tissue as a liquid or semi-liquid and which solidify upon exposure to body temperature of the mammal. The implants erode over a prescribed period of time and elute a drug. The implants also form a seal with the skin or mucosa surrounding the cavity to prevent the entry of bacterial pathogens.

Priority: US20070991903P Applic. Date: 2007-12-03; WO2008US85259 Applic. Date: 2008-12-02

Inventor: ALUR HEMANT H [US]; HARWICK JAMES A H [US]; MONDAL PRAVAKAR [US]; JOHNSTON THOMAS P [US]


Application No.: US20100324460A1  Published: 23/Dec/2010

Title: INTRAORAL APPLIANCE FOR CLEANING TEETH

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 12/599738   Filing Date: 08/May/2008

Abstract:The self-contained intraoral appliance includes first and second substantially rigid bands (12, 14) configured to fit along the outer and the inner surfaces of a row of teeth in the mouth. A motor (20) driven by a battery is connected to the bands through a connecting assembly (2, 24, 28, 34, 40 and 44) in such a manner that one end of the first band moves through a displacement to brush the teeth while the other end remains substantially stationary, and such that an opposing end of the second band moves through a displacement while the other end remains substantially stationary. Brush elements (16, 18) are mounted on the surfaces of the bands to provide cleansing of the teeth.

Priority: US20070939413P Applic. Date: 2007-05-22; WO2008IB51834 Applic. Date: 2008-05-08

Inventor: VAN DER RIJT JOOST ADRIANUS JOHANNES [NL]; SCHALLIG MICHIEL ALLAN AURELIUS [NL]; STAPELBROEK MARTINUS BERNARDUS [NL]; JANSSEN JOZEF JOHANNES MARIA [NL]; VRIJBURG FOLKERT [NL]


Application No.: US20100325822A1  Published: 30/Dec/2010

Title: Method and Device for Cleaning Teeth

Applicant/Assignee:

Application No.: 12/831299   Filing Date: 07/Jul/2010

Abstract:The invention is directed to a method and a device for cleaning teeth wherein a variety of cleaning tools are coupled to a common handle section for the individual cleaning of teeth. It relates in particular to a handle section of an electric dental cleaning device, with a coupling section for coupling various cleaning tools thereto, as well as said cleaning tools. According to the invention the handle section detects a coding provided on the respective cleaning tool attached. In dependence upon the respective coding detected, various functions of the dental cleaning device are controlled.

Priority: US2004-872016 Applic. Date: 2004-06-18; US2003-662237 Applic. Date: 2003-09-15; WO2001EP02844 Applic. Date: 2001-03-14

Inventor: HILSCHER ALEXANDER [DE]; MANNEBACH HORST [DE]; REICK HANSJOERG [DE]; SCHWARZ-HARTMANN ARMIN [DE]; TRAWINSKI PETER [DE]; STRATMANN MARTIN [DE]; VORBECK WOLFGANG [DE]


Application No.: US20100326444A1  Published: 30/Dec/2010

Title: SANITARY MASK FOR THE PROTECTION OF OTHERS

Applicant/Assignee:

Application No.: 12/739923   Filing Date: 03/Jan/2009

Abstract:Disclosed is a sanitary mask for hygienically protecting others that can be conveniently re-used and has a simple structure firmly maintained while the sanitary mask is used, so as to surely achieve the purpose of the sanitary mask, by molding the overall frame of plastics and improving the structure from a structure of preceding Korean Patent Application No. 10-2007-111003, which was filed by the inventor(s) of the present invention before the filing of the present patent application. The sanitary mask for hygienically protecting other people by blocking unsanitary substances provided by respiratory organs including a mouth and a nose of a user from spreading to and contaminating a clean object while exposing the respiratory organs comprising: a lower body molded in a curved shape, i.e., a 'U' shape, and including supporters to be hung on the ears of the user or to be wound around a back head of the user at the ends of both sides of the lower body

and a respiratory organ front cover configured to be inclined upward from an upper portion of a front portion of the lower body and cover a front portion of an area around the respiratory organs of the user to thereby expose the respiratory organs of the user.

Priority: KR20080002195 Applic. Date: 2008-01-08; WO2009KR00018 Applic. Date: 2009-01-03

Inventor: SHIM KYU-SUNG [KR]


Application No.: US20100326454A1  Published: 30/Dec/2010

Title: Smokeless Tobacco Product

Applicant/Assignee:

Application No.: 12/494960   Filing Date: 30/Jun/2009

Abstract:A melt spun tobacco composition, e.g., in flake or particle form, for oral use in a mammal made by melt spinning comprising tobacco and/or a tobacco extract and at least one material which is solid at room temperature, which melts at or below 500 DEG F., and carries from 1% to 70% of tobacco when processed through melt spinning, and solidifies again in less than 5 seconds after melt spinning.

Priority:

Inventor: FUISZ RICHARD C [US]


Application No.: US20100329996A1  Published: 30/Dec/2010

Title: Novel Combination of Therapeutic Agents

Applicant/Assignee: GLAXO GROUP LIMITED

Application No.: 12/677160   Filing Date: 12/Sep/2008

Abstract:Novel combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist and/or a corticosteroid for inhaled administration via the nose or mouth, and methods of using them are provided herein.

Priority: US20070971646P Applic. Date: 2007-09-12; US20080092917P Applic. Date: 2008-08-29; WO2008US76122 Applic. Date: 2008-09-12

Inventor: LAINE DRAMANE IBRAHIM [US]


Application No.: US20100330000A1  Published: 30/Dec/2010

Title: ENZYMES FOR TREATMENT OF GINGIVITIS

Applicant/Assignee:

Application No.: 12/741781   Filing Date: 05/Nov/2008

Abstract:The invention relates to a method for treating, controlling and/or preventing diseases of the oral cavity, particularly diseases and disorders induced accumulation of plaque, by administering a chewing gum composition comprising at least one krill enzyme. Specifically, the invention is directed to a method for preventing, treating and controlling the development of gingivitis, gum disease and symptoms thereof using a composition having a krill enzyme concentration of about 0.005 U/g to about 0.05 U/g of the chewing gum composition.

Priority: US20070985860P Applic. Date: 2007-11-06; WO2008EP65029 Applic. Date: 2008-11-05

Inventor: HELLGREN KRISTIAN [SE]; RUTMAN MAX [CL]; VINCENT JAN [SE]


Application No.: US20100330001A1  Published: 30/Dec/2010

Title: ANTIBACTERIAL COMPOSITIONS

Applicant/Assignee:

Application No.: 12/762234   Filing Date: 16/Apr/2010

Abstract:The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Priority: US20090169845P Applic. Date: 2009-04-16

Inventor: KAWAI TOSHIHISA [US]; STASHONKO PHLLIP P [US]; HOSOKAWA YOSHIAKA [JP]; OHARA KAZUHISA [JP]


Application No.: US20100330002A1  Published: 30/Dec/2010

Title: COMPOSITIONS AND METHODS COMPRISING BASIC AMINO ACID PEPTIDES AND PROTEASES

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866663   Filing Date: 06/Feb/2009

Abstract:The present invention is directed to compositions comprising peptides comprising a basic amino acid. e.g., arginine, and a protease.

Priority: US20080027431P Applic. Date: 2008-02-08; US20080027432P Applic. Date: 2008-02-08; US20080027420P Applic. Date: 2008-02-08; US20080027435P Applic. Date: 2008-02-08; US20080027442P Applic. Date: 2008-02-09; US20080027584P Applic. Date: 2008-02-11; WO2009US33285 Applic. Date: 2009-02-06

Inventor: ROBINSON RICHARD SCOTT [US]; SULLIVAN RICHARD J [US]


Application No.: US20100330003A1  Published: 30/Dec/2010

Title: ORAL CARE PRODUCT AND METHODS OF USE AND MANUFACTURE THEREOF

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/866786   Filing Date: 06/Feb/2009

Abstract:This invention relates to methods of treating early enamel lesions comprising applying an effective amount of a basic amino acid in free or salt form, together with fluoride to a patient in need thereof.

Priority: US20080027427P Applic. Date: 2008-02-08; WO2009US33296 Applic. Date: 2009-02-06

Inventor: ROBINSON RICHARD SCOTT [US]; CUMMINS DIANE [US]; SULLIVAN RICHARD J [US]; ELLWOOD ROGER [GB]


Application No.: US20100330004A1  Published: 30/Dec/2010

Title: Non-Petrochemically Derived Cationic Emulsifiers That are Neutralized Amino Acid Esters and Related Compositions and Methods

Applicant/Assignee: INOLEX INVESTMENT CORPORATION

Application No.: 12/825555   Filing Date: 29/Jun/2010

Abstract:The invention includes a method of increasing the substantivity of a personal care composition to hair, skin or nails by preparing a composition of an aqueous phase, a non-aqueous phase and a neutralized amino acid ester that is a reaction product of a neutral amino acid having a non-polar side chain with a long chain fatty alcohol and is represented by formula (I): wherein R1 is an alkyl group

R2 is a linear or branched carbon chain

and the amine group of the amino acid is neutralized with an acid. The composition is substantially free of petrochemicals and/or derivatives of petrochemical materials. The aqueous phase and the non-aqueous phase are emulsified by the neutralized amino acid ester. Other methods and an emulsifiers that is the neutralized amino acid ester are included. Because the neutralized amino acid ester and the compositions do not contain petrochemical-derived ingredient, the products are natural.

Priority: US20090221154P Applic. Date: 2009-06-29

Inventor: BURGO ROCCO [US]


Application No.: US20100330005A1  Published: 30/Dec/2010

Title: DENTAL ORAL COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

Application No.: 12/863330   Filing Date: 15/Jan/2009

Abstract:A dental composition for oral use, containing a phosphorylated saccharide (a), a polyphosphoric acid and/or a salt thereof (b), and a cationic bactericidal agent (c), wherein a ratio of a total amount of the phosphorylated saccharide (a) and the polyphosphoric acid and/or a salt thereof (b) contained to an amount of the cationic bactericidal agent (c) contained, i.e. {(a)+(b)}/(c), is from 0.05 to 20 in a weight ratio. The dental composition for oral use of the present invention can be suitably used for an oral cavity cleaning agent, including dentifrice agents such as a paste dentifrice agent, a powder dentifrice agent, and a liquid dentifrice agent, a mouse-wash agent, a troche, a tablet, a cream, an ointment, a bonding agent, a mouth spray, a coating agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, wet tissue for oral cavity care, an oral refreshing agent, chewing gum, or a gargling agent, or the like.

Priority: JP20080008428 Applic. Date: 2008-01-17; WO2009JP50476 Applic. Date: 2009-01-15

Inventor: YOSHIDA YASUHIRO [JP]; NAMBA NAOKO [JP]; NAGAOKA NORIYUKI [JP]; TAKASHIBA SHOGO [JP]; SUZUKI KAZUOMI [JP]; NOJIRI YAMATO [JP]; ISHINO HIROSHIGE [DE]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]


Application No.: US20100330063A1  Published: 30/Dec/2010

Title: STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS

Applicant/Assignee: GLIAMED, INC

Application No.: 12/519499   Filing Date: 17/Dec/2008

Abstract:A new use is provided for small molecule inhibitors of Oct4 and Sox 2 as a cellular reprogramming agent and a method of reprogramming adult mammalian somatic cells into stem-like cells is provided, using small molecule inhibitors of Oct4 and Sox 2 without the need of any material derived from embryos or fetuses, and without the need of potentially harmful transfecting vectors. Stem-like cells created by the present invention can be induced to differentiate into terminally differentiated adult somatic cells, such as, for example, neuronal cells.

Priority: US20070014087P Applic. Date: 2007-12-17; WO2008US13843 Applic. Date: 2008-12-17

Inventor: WEINSTEIN DAVID E [US]


Application No.: US20100330086A1  Published: 30/Dec/2010

Title: CATIONIC STEROID ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/876993   Filing Date: 07/Sep/2010

Abstract:The invention provides methods for decreasing or inhibiting herpesviridae (HV) infection or pathogenesis of a cell in vitro, ex vivo or in vivo, a symptom or pathology associated with a herpesviridae (HV) infection or pathogenesis in vitro, ex vivo or in vivo, or an adverse side effect of herpesviridae (HV) infection or pathogenesis in vitro, ex vivo or in vivo. In one embodiment, a method of the invention includes treating a subject with an invention compound (e.g., cationic steroid antimicrobial or CSA).

Priority: US2007-669803 Applic. Date: 2007-01-31; US20060764129P Applic. Date: 2006-02-01

Inventor: SAVAGE PAUL B [US]; LEUNG DONALD [US]


Application No.: US20100330136A1  Published: 30/Dec/2010

Title: USE OF CATIONIC SURFACTANTS FOR THE PROTECTION AGANST TOOTH EROSION

Applicant/Assignee:

Application No.: 12/812813   Filing Date: 11/Feb/2009

Abstract:This invention relates to a use of a composition for protecting oral cavity and teeth containing ethyl-N[alpha]-lauroyl-L-arginate HCl (LAE), a corresponding composition and a corresponding method for protecting teeth. Because of nearly epidemic incidence of dental erosion, there is a continuing need for improved products that provide protection against dental erosion. Hence, it is an object of the present invention to protect teeth against dental erosion. Surprisingly, it has been found that ethyl-N[alpha]-lauroyl-L-arginate HCl (LAE) and its salts attach to teeth and provide protection of teeth from erosion especially caused by the action of acid in food products and drinks such as chewing gum and lozenges compositions. Special advantages of this invention are: (a) sustained coating of the teeth by LAE and its homologues

(b) the coating agent provides a source of neutralizing plaque acids by providing sustained base formation. This is because arginines in LAE is degraded by bacteria on tooth in the mouth to produce ammonia. Thus, this chemistry not only provides the coating protection but also generates base to maintain pH balance on a sustained basis

and (c) avoid the use of brushing with abrasive cleansers.

Priority: EP20080382007 Applic. Date: 2008-02-13; US20080045393P Applic. Date: 2008-04-16; WO2009EP51587 Applic. Date: 2009-02-11

Inventor: ROCABAYERA BONVILA XAVIER [ES]


Application No.: US20100330157A1  Published: 30/Dec/2010

Title: BIOMATERIAL FOR THE CONTROLLED DELIVERY OF INGREDIENTS

Applicant/Assignee: MA.I.A WOUNDCARE

Application No.: 12/742588   Filing Date: 13/Nov/2008

Abstract:The disclosure relates to a biomaterial that comprises an aqueous phase, polymer network, a second polymer included in said disclosure invention more particularly relates to a biomaterial including an aqueous phase and a first polymer network made of a first proteic or saccharidic polymer or a mixture of first proteic and saccharidic polymers, wherein the first polymer network and the aqueous phase define a first gel (A), the biomaterial including: a second proteic or saccharidic polymer or a mixture of the second proteic and saccharidic polymers, either in solution in the aqueous phase of the gel (A) or in the form of a gel (B), and a first enzyme for degrading said second polymer or second polymer network. The disclosure also relates to a method for making biomaterials, and to the uses of the biomaterial particularly for releasing active substances, and to a device for the controlled release of active substances that include the biomaterial. The disclosure can particularly be used in the field of cosmetics and pharmaceuticals.

Priority: US20070987785P Applic. Date: 2007-11-14; WO2008FR01596 Applic. Date: 2008-11-13

Inventor: LARETTA-GARDE VERONIQUE [FR]; PICARD JULIEN [FR]; KLAK MARIE CECILE [FR]; PERRIN SEBASTIEN [FR]; GIRAUDIER SEBASTIEN [FR]


Application No.: US20100330684A1  Published: 30/Dec/2010

Title: DIAGNOSTIC DEVICE AND METHOD

Applicant/Assignee: HYDRADX, INC

Application No.: 12/881166   Filing Date: 13/Sep/2010

Abstract:Diagnostic devices and methods involve comparison of relative levels of first and second components and/or characteristics of a fluid sample (e.g., saliva), preferably using antibodies arranged to interact with selected components, and colorimetric indicators that are bound or released in proportion to relative concentration or amount of the components or characteristics, as indicative of a health condition such as dehydration state, shock state, stress state, disease state, drug consumption, and drug metabolization. Amylase and IgA may be selected as specific salivary components of interest.

Priority: WO2010US21295 Applic. Date: 2010-01-17; US20090241868P Applic. Date: 2009-09-12; US20090150135P Applic. Date: 2009-02-05

Inventor: O'CONNOR STEPHEN D [US]


Application No.: US20100331168A1  Published: 30/Dec/2010

Title: MAGNESIUM-SUBSTITUTED HYDROXYAPATITES

Applicant/Assignee:

Application No.: 12/768715   Filing Date: 27/Apr/2010

Abstract:A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.

Priority: US2005-089745 Applic. Date: 2005-03-25; US2001-800127 Applic. Date: 2001-03-06

Inventor: RIMAN RICHARD E [US]; SUCHANEK WOJCIECH [US]; SHUK PAVEL [US]; TENHUISEN KEVOR S [US]; CHEN CHUN-WEI [US]


Application No.: US20100331305A1  Published: 30/Dec/2010

Title: OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee: GENENTECH, INC

Application No.: 12/821998   Filing Date: 23/Jun/2010

Abstract:Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).

Priority: US20090252284P Applic. Date: 2009-10-16; US20090220011P Applic. Date: 2009-06-24

Inventor: BERGERON PHILIPPE [US]; COHEN FREDERICK [US]; ESTRADA ANTHONY [US]; KOEHLER MICHAEL F T [US]; LY CUONG [US]; LYSSIKATOS JOSEPH P [US]; PEI ZHONGHUA [US]; LEE WENDY [US]; ZHAO XIANRUI [US]


Application No.: US20100331386A1  Published: 30/Dec/2010

Title: ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/825168   Filing Date: 28/Jun/2010

Abstract:This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.

Priority: US20090221424P Applic. Date: 2009-06-29

Inventor: CHAFEEV MIKHAIL [CA]; FU JIANMIN [CA]; CADIEUX JEAN-JACQUES [CA]


Application No.: US20100331444A1  Published: 30/Dec/2010

Title: COMPOSITION CONTAINING UNSATURATED SILICONE COMPOUNDS, DENTAL MATERIALS CONTAINING THEM AND USE THEREOF

Applicant/Assignee: 3M ESPE AG (A WHOLLY-OWNED SUBSIDUARY OF 3M COMPANY)

Application No.: 12/875426   Filing Date: 03/Sep/2010

Abstract:The invention relates to a curable composition comprising addition curable silicone component (A) having a linear siloxane backbone at least one unsaturated, non-activated side group pendant from the Si atom or atoms in the backbone, component (A) having an equivalent weight in the range of about 68 to about 1000, crosslinker component (B) comprising at least 2SiH groups, catalyst component (C) being able to catalyse the reaction between component (A) and component (B), filler component (D), wherein the equivalent weight is defined as (molecular weight of the molecule)/(number of unsaturations in the molecule).

Priority: EP20040024243 Applic. Date: 2004-10-12; US2005-247040 Applic. Date: 2005-10-11

Inventor: BISSINGER PETER [DE]; ZECH JOACHIM W [DE]


Application No.: US20100331765A1  Published: 30/Dec/2010

Title: Unit Dose Drug Delivery Platform

Applicant/Assignee: MYSTIC PHARMACEUTICALS, INC

Application No.: 12/851524   Filing Date: 05/Aug/2010

Abstract:The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.

Priority: US2008-971471 Applic. Date: 2008-01-09; US20070982643P Applic. Date: 2007-10-25; US20070978619P Applic. Date: 2007-10-09; US20070944700P Applic. Date: 2007-06-18; US20070938379P Applic. Date: 2007-05-16; US20090231587P Applic. Date: 2009-08-05

Inventor: SULLIVAN TIMOTHY R [US]; NELSON JEFFREY [US]

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LIST OF US PATENT APPLICATIONS IN ORAL CARE FORMULATIONS PUBLISHED IN 2010
This list includes Provisional Patent Applications published in the United States. The list was retrieved by using a refined search strategy on the claims section of all patent applications.
Salient search terms included oral care formulations and compositions for tooth cleaning and whitening; denture and dental prosthesis care; caries, calculus, stains and plaque prevention,
reduction and removal of plaque; dental adhesives, dental polymers, cement curing; polymer UV curing, cavity fillers, disinfectants, bleaching; oral hygiene and devices, etc.
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