US PROVISIONAL PATENT APPLICATIONS IN EXCIPIENTS, DELIVERY AND RELEASE OF PHARMACEUTICAL COMPOSITIONS PUBLISHED IN 2012
This list includes Provisional Patent Applications published in the United States. The list was retrieved by searching the claims section of all patent applications. Salient search terms
included pharmaceutical formulations, excipients, strips, gums, cellulose, lozenge, tablets, capsules, suppositories; solid dosage, nasal inhalation; time, control or sustained drug release;
polysaccharides, polymeric excipients, hyaluronic acid, micro- and nano-spheres, carbomer, povidone, polyacrylates, polymerthacrylates; emulsions; enemas, vaginal, rectal, nasal, ocular
or buccal administration of medications, etc.
US Patent Applications in Excipients, Delivery and Release of
Pharmaceutical Compositions and Actives Published in 2012

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US PATENT APPLICATIONS IN PHARMACEUTICAL EXCIPIENTS AND FORMULATION PUBLISHED IN 2012



Application No.: US20120003176A1  Published: 05/Jan/2012

Title: HYDROGEL-FORMING COMPOSITION COMPRISING NATURAL AND SYNTHETIC SEGMENTS

Applicant/Assignee: ZIMMER ORTHOBIOLOGICS, INC

Application No.: 13/174121   Filing Date: 30/Jun/2011

Abstract:

A hydrogel composition is formed from a natural polymer derivative having a plurality of cross-linkable units depending therefrom, and a synthetic polymer derivative having a plurality of cross-linkable units depending therefrom, said natural and synthetic polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of natural and synthetic polymers provides for biodegradability of the hydrogel, along with mechanical properties such as strength and elasticity.

Priority: US2010-361182P Applic. Date: 2010-07-02

Inventor: HUANG XIAO [US]; YAO JIAN Q [CN]; GAO JIZONG [US]; ZAPOROJAN VICTOR [US]; GUO JOE ZHE [US]


Application No.: US20120003315A1  Published: 05/Jan/2012

Title: Flowable Carrier Matrix

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 13/233100   Filing Date: 15/Sep/2011

Abstract:

A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenetic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.

Priority: US2010-977310 Applic. Date: 2010-12-23; US2009-634323 Applic. Date: 2009-12-09; US2006-504363 Applic. Date: 2006-08-14

Inventor: BEALS NEIL [US]; SCIFERT JEFFREY L [US]; BODEN SCOTT D [US]


Application No.: US20120004305A1  Published: 05/Jan/2012

Title: EXTERNAL PREPARATION CONTAINING ANALGESIC/ANTI-INFLAMMATORY AGENT

Applicant/Assignee: KOWA CO., LTD

Application No.: 13/256024   Filing Date: 11/Mar/2010

Abstract:

An external preparation containing the following components (A), (B), (C), and (D): (A) a non-steroidal analgesic/anti-inflammatory agent, (B) a terpene and/or an essential oil containing a terpene, (C) a higher alcohol, and (D) a polyoxyalkylene alkyl ether and/or a polyoxyalkylene alkenyl ether. The external preparation of the present invention has improved skin permeation, and can thus be effective at a low concentration, and also has excellent appearance.

Priority: JP20090057972 Applic. Date: 2009-03-11; WO2010JP01760 Applic. Date: 2010-03-11

Inventor: MIURA SEIJI [JP]; KANEBAKO MAKOTO [JP]


Application No.: US20120004322A1  Published: 05/Jan/2012

Title: PICEATANNOL-CONTAINING COMPOSITION AND METHOD OF PRODUCING PICEATANNOL-CONTAINING COMPOSITION

Applicant/Assignee: MORINAGA & CO., LTD

Application No.: 13/256552   Filing Date: 03/Apr/2009

Abstract:

Provided are a piceatannol-containing composition which is a composition originating in a natural material and containing piceatannol at a high concentration, and a method of producing the piceatannol-containing composition. A piceatannol-containing composition which contains 0.0001 to 99.9% by mass of piceatannol is obtained by extracting passion fruit seeds. The extraction of piceatannol is carried out by grinding the passion fruit seeds, adding at least one solvent selected from an aqueous alcohol-based solvent and an aqueous ketone-based solvent and agitating to thereby extract piceatannol into the above-described solvent. In this case, it is preferable to conduct stepwise extraction by using both of the aqueous alcohol-based solvent and the aqueous ketone-based solvent.

Priority: WO2009JP56945 Applic. Date: 2009-04-03

Inventor: MATSUI YUKO [JP]; KAMEI MASANORI [JP]; SUGIYAMA KENKICHI [JP]


Application No.: US20120009260A1  Published: 12/Jan/2012

Title: NANOPARTICLE FILM DELIVERY SYSTEMS

Applicant/Assignee:

Application No.: 13/157836   Filing Date: 10/Jun/2011

Abstract:

A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.

Priority: US2010-353366P Applic. Date: 2010-06-10

Inventor: SCHOBEL ALEXANDER M [US]; MYERS GARRY L [US]; KENDALL KEITH JOSEPH [US]; RADEMACHER THOMAS [GB]; MOUS JAN [CH]; BARRY JUSTIN N W [ES]; WILLIAMS PHILLIP [GB]; BARRIENTOS AFRICA GARCIA [ES]


Application No.: US20120009261A1  Published: 12/Jan/2012

Title: NOVEL GASTRO-RETENTIVE DOSAGE FORMS

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 13/176798   Filing Date: 06/Jul/2011

Abstract:

A gastro-retentive pharmaceutical dosage form of a therapeutically effective amount of at least one GABA Analog, at least one opioid, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for formulating for once daily or twice daily administration. Further provided is a method of treating a disorder by administering to a patient in need thereof, a gastro-retentive pharmaceutical dosage form of a therapeutically effective amount of at least one GABA Analog, at least one opioid, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration. The opioid is either in slow release form or in immediate release form.

Priority: US2010-399045P Applic. Date: 2010-07-06

Inventor: SESHA RAMESH [US]


Application No.: US20120010301A1  Published: 12/Jan/2012

Title: ORGANOLEPTIC COMPOUNDS

Applicant/Assignee:

Application No.: 13/234274   Filing Date: 16/Sep/2011

Abstract:

The present invention is directed to novel fragrance compounds and their unexpected advantageous use in enhancing, improving or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: wherein the dotted line represents a single or double bond, and R is selected from the group consisting of propyl, butyl, and pentyl.

Priority: US2010-908038 Applic. Date: 2010-10-20; US2010-692682 Applic. Date: 2010-01-25; US2007-958038 Applic. Date: 2007-12-17

Inventor: CLOSSON ADAM P [US]; MONTELEONE MICHAEL G [US]


Application No.: US20120010557A1  Published: 12/Jan/2012

Title: Drug Delivery System for Use in the Treatment of Vascular and Vessel-Related Pathologies

Applicant/Assignee:

Application No.: 13/145780   Filing Date: 26/Jan/2010

Abstract:

The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a thrombus in the vessel to be treated. The platform is preferably formed by liposomes that are sterically stabilized by grafting of poly(ethylene glycol) onto the liposome surface. The liposomes may further comprise photosensitizers and targeting molecules. The liposomes may be thermosensitive. The compound is suitably tranexamic acid. The drug delivery system is preferably used for the treatment of port wine stains.

Priority: EP20090151332 Applic. Date: 2009-01-26; WO2010EP50833 Applic. Date: 2010-01-26

Inventor: HEGER MICHAL [NL]


Application No.: US20120010599A1  Published: 12/Jan/2012

Title: INORGANICALLY SURFACE-MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THEM

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 13/176907   Filing Date: 06/Jul/2011

Abstract:

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

Priority: US2010-361815P Applic. Date: 2010-07-06

Inventor: JIN SUNGHO [US]; SMITH GARRETT [US]; CHOI CHULMIN [US]


Application No.: US20120014900A1  Published: 19/Jan/2012

Title: Personal Care Composition Comprising a Near-Terminal Branched Compound

Applicant/Assignee:

Application No.: 13/182943   Filing Date: 14/Jul/2011

Abstract:

A personal care composition comprising: a near-terminal branched compound according to Formula I

a cosmetically acceptable aqueous carrier

wherein the near-terminal branched compound is not comprised in a gel network.

Priority: US2010-364519P Applic. Date: 2010-07-15

Inventor: CARTER JOHN DAVID [US]; BURT ELAINE MARIE [US]; SCHEIBEL JEFFREY JOHN [US]; KITKO DAVID JOHNATHAN [US]; XU JUN [US]; SAUNDERS CHARLES WINSTON [US]; PRICE KENNETH NATHAN [US]; URBIN STEPHANIE ANN [US]; GREEN PHILLIP RICHARD [US]


Application No.: US20120021052A1  Published: 26/Jan/2012

Title: CONTROLLED RELEASE AND TASTE MASKING ORAL PHARMACEUTICAL COMPOSITION

Applicant/Assignee: COSMO TECHNOLOGIES LIMITED

Application No.: 13/226758   Filing Date: 07/Sep/2011

Abstract:

Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.

Priority: IT1999MI01317 Applic. Date: 1999-06-14; IT2000MI00422 Applic. Date: 2000-03-03; US2008-210969 Applic. Date: 2008-09-15; US2001-009532 Applic. Date: 2001-12-12; WO2000EP05356 Applic. Date: 2000-06-09

Inventor: VILLA ROBERTO [IT]; PEDRANI MASSIMO [IT]; AJANI MAURO [IT]; FOSSATI LORENZO [IT]


Application No.: US20120021053A1  Published: 26/Jan/2012

Title: CONTROLLED RELEASE AND TASTE-MASKING ORAL PHARMACEUTICAL COMPOSITION

Applicant/Assignee: COSMO TECHNOLOGIES LIMITED

Application No.: 13/249839   Filing Date: 30/Sep/2011

Abstract:

Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.

Priority: IT1999MI01317 Applic. Date: 1999-06-14; IT2000MI00422 Applic. Date: 2000-03-03; US2008-210969 Applic. Date: 2008-09-15; US2001-009532 Applic. Date: 2001-12-12; WO2000EP05356 Applic. Date: 2000-06-09

Inventor: VILLA ROBERTO [IT]; PEDRANI MASSIMO [IT]; AJANI MAURO [IT]; FOSSATI LORENZO [IT]


Application No.: US20120022023A1  Published: 26/Jan/2012

Title: Hydraulic Cements, Methods and Products

Applicant/Assignee:

Application No.: 13/128034   Filing Date: 12/Nov/2009

Abstract:

Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of a powder composition and a non-aqueous water-miscible liquid. In one embodiment, powder composition is a Brushite or Monetite-forming calcium phosphate powder composition. In another embodiment, the powder composition comprises porous [beta]-tricalcium phosphate ([beta]-TCP) granules and at least one additional calcium phosphate powder. In another embodiment, the powder composition comprises calcium silicate powder. In a further embodiment, the powder composition comprises calcium aluminate powder. In another embodiment, the powder composition is a cement composition and comprises nanopowders having a grain size of less than 1 micron. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.

Priority: US2008-113843P Applic. Date: 2008-11-12; US2008-113852P Applic. Date: 2008-11-12; US2008-113840P Applic. Date: 2008-11-12; US2008-113857P Applic. Date: 2008-11-12; WO2009IB55042 Applic. Date: 2009-11-12; US2009-184413P Applic. Date: 2009-06-05

Inventor: ENGQVIST HAAKAN [SE]; ABERG JONAS [SE]


Application No.: US20120022037A1  Published: 26/Jan/2012

Title: AQUEOUS HAIR CLEANSING AGENT

Applicant/Assignee: KAO CORPORATION

Application No.: 13/258246   Filing Date: 26/Mar/2010

Abstract:

The present invention relates to an aqueous hair cleansing agent which includes the following components (A), (B): (A) sulfate-type anionic surfactant having a specific structure, (B) polyoxyethylene alkyl ether-type nonionic surfactant having a specific structure, and water, wherein ratio of weight represented by (B)/((A)+(B)) is 1% to 25%.

Priority: JP20090084332 Applic. Date: 2009-03-31; JP20090084335 Applic. Date: 2009-03-31; WO2010JP02179 Applic. Date: 2010-03-26

Inventor: TERADA EIJI [JP]


Application No.: US20120022170A1  Published: 26/Jan/2012

Title: MANUFACTURE OF TABLET IN A DIE UTILIZING POWDER BLEND CONTAINING WATER-CONTAINING MATERIAL

Applicant/Assignee:

Application No.: 13/246884   Filing Date: 28/Sep/2011

Abstract:

The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water-containing material within the tablet shape above its dehydration temperature to form the tablet.

Priority: US2009-245315P Applic. Date: 2009-09-24; US2010-887552 Applic. Date: 2010-09-22; US2009-255582P Applic. Date: 2009-10-28; US2010-314629P Applic. Date: 2010-03-17; US2010-358167P Applic. Date: 2010-06-24

Inventor: BUNICK FRANK J [US]; SOWDEN HARRY S [US]; LUBER JOSEPH R [US]; KRIKSUNOV LEO B [US]; SZYMCZAK CHRISTOPHER E [US]


Application No.: US20120027775A1  Published: 02/Feb/2012

Title: ABSORBABLE PEG-BASED HYDROGELS

Applicant/Assignee: ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC

Application No.: 13/193958   Filing Date: 29/Jul/2011

Abstract:

An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms

where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.

Priority: US2010-369818P Applic. Date: 2010-08-02

Inventor: WON CHEE-YOUB [US]; CUI HELEN [US]


Application No.: US20120027858A1  Published: 02/Feb/2012

Title: Methods and Compositions for Managing Cancer Cell Growth

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 13/147695   Filing Date: 04/Feb/2010

Abstract:

The invention relates to composition and a method of using the composition for modulating proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.

Priority: WO2010US23237 Applic. Date: 2010-02-04; US2009-252358P Applic. Date: 2009-10-16; US2009-149885P Applic. Date: 2009-02-04

Inventor: FRANSES JOSEPH W [US]; EDELMAN ELAZER R [US]; CARDOSO ANGELO MANUEL DE ALMEIDA [US]; NUGENT HELEN MARIE [US]


Application No.: US20120027879A1  Published: 02/Feb/2012

Title: BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING METABOLIC DISORDERS

Applicant/Assignee: VELCERA, INC

Application No.: 13/197207   Filing Date: 03/Aug/2011

Abstract:

Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent

formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant

formulation III: non-polar solvent, active compound, and optional flavoring agent

and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.

Priority: US2002-230084 Applic. Date: 2002-08-29; US2000-537118 Applic. Date: 2000-03-29; US2004-928989 Applic. Date: 2004-08-27; US2010-692213 Applic. Date: 2010-01-22; WO1997US17899 Applic. Date: 1997-10-01

Inventor: DUGGER III HARRY A [US]


Application No.: US20120034304A1  Published: 09/Feb/2012

Title: Prolonged Release Pharmaceutical Composition Containing 3-(3-Dimethylamino-1-Ethyl-2-Methyl-Propyl)Phenol

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 13/242800   Filing Date: 23/Sep/2011

Abstract:

A pharmaceutical formulation for prolonged release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt. % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.5 hours

5 to 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 1 hour

10 to 75% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 2 hours

15 to 82% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 3 hours

30 to 97% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 6 hours

more than 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 12 hours

more than 70% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 18 hours, and more than 80% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 24 hours.

Priority: DE20011052469 Applic. Date: 2001-10-24; DE20021048309 Applic. Date: 2002-10-16; US2004-831368 Applic. Date: 2004-04-26; WO2002EP11809 Applic. Date: 2002-10-22

Inventor: BARTHOLOMAEUS JOHANNES [DE]; ZIEGLER IRIS [DE]


Application No.: US20120035107A1  Published: 09/Feb/2012

Title: COMPOSITIONS FOR ACHIEVING A THERAPEUTIC EFFECT IN AN ANATOMICAL STRUCTURE

Applicant/Assignee:

Application No.: 13/244294   Filing Date: 24/Sep/2011

Abstract:

Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Priority: US2004-015943 Applic. Date: 2004-12-17; US2008-198749 Applic. Date: 2008-08-26; US2001-781599 Applic. Date: 2001-02-12

Inventor: ROORDA WOUTER E [US]; PACETTI STEPHEN D [US]


Application No.: US20120035275A1  Published: 09/Feb/2012

Title: Emulsion, Method For Producing The Same, And Cosmetic Raw Material Formed From The Same

Applicant/Assignee:

Application No.: 13/140305   Filing Date: 21/Dec/2009

Abstract:

The present invention has objectives to provide an emulsion suitable as a cosmetic raw material and to easily obtain the aforementioned emulsion of organopolysiloxane exhibiting superior storage stability. The present invention provides an emulsion comprising (A) an organopolysiloxane, (B) a methyl polyglycerol-modified silicone-based surfactant having a specified structure, and (C) an aqueous medium, and provides a method for producing an emulsion characterized by obtaining an emulsion by emulsifying a mixture of (A) a organopolysiloxane and (B) a silicone-based surfactant, which is obtained by synthesizing the silicone-based surfactant of component (B) in the component (A).

Priority: JP20080326578 Applic. Date: 2008-12-22; WO2009JP71831 Applic. Date: 2009-12-21

Inventor: KOJIMA KAZUHIKO [JP]; NAGANAWA TSUTOMU [JP]; HARASHIMA ASAO [JP]; OKAWA TADASHI [JP]


Application No.: US20120035276A1  Published: 09/Feb/2012

Title: TISSUE REGENERATIVE COMPOSITION, METHOD OF MAKING, AND METHOD OF USE THEREOF

Applicant/Assignee:

Application No.: 13/228795   Filing Date: 09/Sep/2011

Abstract:

A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.

Priority: US2003-337152 Applic. Date: 2003-01-07; US2000-691345 Applic. Date: 2000-10-18; US1999-171733P Applic. Date: 1999-12-22

Inventor: SPIEVACK ALAN R [US]


Application No.: US20120039796A1  Published: 16/Feb/2012

Title: Novel method for creating, suspending and stabilizing electronically modified oxygen derivatives, along with creating, suspending and stabilizing electronically modified reaction intermediates, in a bio compatible fluorocarbon suspension, for the purpose of inducing a cascading immune response in mammalian patients

Applicant/Assignee:

Application No.: 13/209369   Filing Date: 13/Aug/2011

Abstract:

A bio compatible free radical suspension, comprising of oxygen and electronically modified reaction intermediates, where a fluorocarbon is used as an inert medium for stabilization of reaction intermediates. A stabilized bio compatible electronically modified derivative suspension is produced by the subjecting a fluorocarbon to certain stressors, such as oxidizing agents, reactive intermediates, physiological gases, benzo-[gamma]-pyrone derivatives, ultrasonic-cavitation, electric fields, magnetic fields, UV radiation, active metal catalyst, surfactant reactants, buffers, electrolytes, glucose, glucose derivatives, for the purpose of inducing a cascading immune response.

Priority: US2010-373836P Applic. Date: 2010-08-15

Inventor: MARKOU DEMETRIOS [US]


Application No.: US20120039977A1  Published: 16/Feb/2012

Title: MICROBE MITIGATING ARCHITECTURAL BARRIERS, COMPOSITIONS FOR FORMING SUCH BARRIERS AND RELATED METHODS

Applicant/Assignee: HENRY COMPANY

Application No.: 13/028476   Filing Date: 16/Feb/2011

Abstract:

The invention includes a microbe-mitigating architectural barrier that includes a barrier forming material, and at least one biocide. The barrier forming material may be a bitumen product, an elastomeric polymer and combinations thereof. The microbe-mitigating architectural barrier may be formed by applying an emulsion composition directly to an architectural surface, or it may be preformed and adhered or otherwise secured to the architectural surface in the form of a sheet or film. The invention also includes architectural assemblies and/or building envelopes that include the microbe-mitigating barrier. Related methods are encompassed within the scope of the invention. Such methods include a method of preparing an architectural barrier that includes: (a) preparing an emulsion that comprises a barrier forming material chosen from a bitumen product, an elastomeric polymer and combinations thereof, and at least one biocide, (b) applying the emulsion to at least one architectural surface, and (c) drying and/and or curing the emulsion to form a barrier.

Priority: US2010-305402P Applic. Date: 2010-02-17

Inventor: DRACOPOULOS JOHN [CA]; BORENSTEIN LIONEL [CA]; MELANCON SHAWN [CA]


Application No.: US20120039980A1  Published: 16/Feb/2012

Title: COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE

Applicant/Assignee:

Application No.: 13/279982   Filing Date: 24/Oct/2011

Abstract:

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.

Priority: US2005-118088 Applic. Date: 2005-04-28; US2004-566569P Applic. Date: 2004-04-28

Inventor: DANILOFF GEORGE Y [US]; SEHL LOUIS C [US]; TROLLSAS OLOF MIKAEL [US]; SCHROEDER JACQUELINE [US]; GRAVETT DAVID M [US]; TOLEIKIS PHILIP M [CA]


Application No.: US20120040001A1  Published: 16/Feb/2012

Title: DISINTEGRATING PARTICLE COMPOSITION AND RAPIDLY DISINTEGRATING COMPRESSION-MOLDED MATERIAL USED THE SAME

Applicant/Assignee: FUJI CHEMICAL INDUSTRY CO., LTD

Application No.: 13/148999   Filing Date: 12/Feb/2010

Abstract:

[Subject Matter] A rapidly disintegrating compression-molded material has been demanded, which exhibits good taking feeling and taste in the oral cavity, has a sufficient hardness for prevent the material from causing problems such as cracking or dusting during the preparation or distribution process, also has a good disintegrating property in the oral cavity, and can be taken in a large amount. [Means to Solve] A disintegrating particle composition is prepared by wet-granulating a starch, a water-soluble binding agent, and if needed a molding agent/an effective ingredient. By incorporating this disintegrating particle composition, a rapidly disintegrating compression-molded material can be prepared which has an excellent taking feeling, taste, hardness and disintegrating property and can be taken without limitation in quantity.

Priority: JP20090029901 Applic. Date: 2009-02-12; WO2010JP00886 Applic. Date: 2010-02-12

Inventor: KOIZUMI HARUKA [JP]; FUKAMI TADASHI [JP]; MACHIMURA HITOSHI [JP]


Application No.: US20120040002A1  Published: 16/Feb/2012

Title: RESORBABLE AND BIOCOMPATIBLE FIBRE GLASS COMPOSITIONS AND THEIR USES

Applicant/Assignee:

Application No.: 13/265832   Filing Date: 20/Apr/2010

Abstract:

Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibres manufactured from these glass compositions, medical devices containing fibres of the invention, the use of these compositions for the manufacture of glass fibre and the use of the fibres for the manufacture of medical devices are also disclosed.

Priority: WO2010EP55192 Applic. Date: 2010-04-20; EP20090158608 Applic. Date: 2009-04-23

Inventor: LEHTONEN TIMO [FI]; TUOMINEN JUKKA [FI]; OLLILA FREDRIK [FI]


Application No.: US20120041020A1  Published: 16/Feb/2012

Title: Methods of Treatment Utilizing Semi-Solid Pharmaceutical Compositions

Applicant/Assignee: A.P. PHARMA, INC, A.P. PHARMA

Application No.: 13/279938   Filing Date: 24/Oct/2011

Abstract:

A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation

and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

Priority: US2000-325790P Applic. Date: 2000-05-11; US2001-854180 Applic. Date: 2001-05-11; US2003-409408 Applic. Date: 2003-04-07; US2004-765768 Applic. Date: 2004-01-26; US2004-953841 Applic. Date: 2004-09-28; US2009-564881 Applic. Date: 2009-09-22

Inventor: NG STEVEN Y [US]; SHEN HUI RONG [US]; HELLER JORGE [US]


Application No.: US20120041021A1  Published: 16/Feb/2012

Title: Process for Preparing a Semi-Solid Delivery Vehicle and Pharmaceutical Compositions

Applicant/Assignee: A.P. PHARMA, INC

Application No.: 13/279949   Filing Date: 24/Oct/2011

Abstract:

A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation

and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

Priority: US2000-325790P Applic. Date: 2000-05-11; US2001-854180 Applic. Date: 2001-05-11; US2003-409408 Applic. Date: 2003-04-07; US2004-765768 Applic. Date: 2004-01-26; US2004-953841 Applic. Date: 2004-09-28; US2009-564881 Applic. Date: 2009-09-22

Inventor: NG STEVEN Y [US]; SHEN HUI-RONG [US]; HELLER JORGE [US]


Application No.: US20120041075A1  Published: 16/Feb/2012

Title: ETHANOL COMPOSITIONS

Applicant/Assignee: CELANESE INTERNATIONAL CORPORATION

Application No.: 13/197743   Filing Date: 03/Aug/2011

Abstract:

In one embodiment, the present invention is to an ethanol composition comprising at least 85 wt. % ethanol and from 95 wppm to 850 wppm isopropanol.

Priority: US2010-332727P Applic. Date: 2010-05-07; US2010-346344P Applic. Date: 2010-05-19; US2010-332728P Applic. Date: 2010-05-07; US2010-332699P Applic. Date: 2010-05-07; US2010-332696P Applic. Date: 2010-05-07; US2010-300815P Applic. Date: 2010-02-02; US2010-889260 Applic. Date: 2010-09-23; US2010-852290 Applic. Date: 2010-08-06

Inventor: JOHNSTON VICTOR [US]; SARAGER LINCOLN [US]; WARNER R JAY [US]; WEINER HEIKO [US]; HORTON TRINITY [US]; JEVTIC RADMILA [US]


Application No.: US20120041076A1  Published: 16/Feb/2012

Title: GEL FORMING SOLUTION AND METHOD FOR PRODUCING GEL

Applicant/Assignee: SEIKO EPSON CORPORATION

Application No.: 13/207640   Filing Date: 11/Aug/2011

Abstract:

A method for producing a gel includes a liquid droplet ejection step in which a first liquid is ejected in the form of a droplet to a second liquid to allow the first liquid and the second liquid to react with each other, thereby producing a gel. The first liquid is a gel forming solution containing an alcohol-based solvent, wherein the alcohol-based solvent is contained therein in an amount of 4% or more by weight and less than 70% by weight of the total amount of the gel forming solution.

Priority: JP20100180107 Applic. Date: 2010-08-11

Inventor: HIRUMA KEI [JP]


Application No.: US20120041077A1  Published: 16/Feb/2012

Title: ORGANOLEPTIC COMPOUNDS AND THEIR USE IN PERFUME COMPOSITIONS

Applicant/Assignee:

Application No.: 13/282864   Filing Date: 27/Oct/2011

Abstract:

The present invention a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the following compound: wherein R1 and R2 independently represent a straight, branched or cyclic hydrocarbon moiety consisting of less than 10, preferably less than 4, most preferably 1 of 2 carbon atoms.

Priority: US2006-464403 Applic. Date: 2006-08-14

Inventor: SMITH CATHERINE MARIE [US]


Application No.: US20120045396A1  Published: 23/Feb/2012

Title: POROUS STRUCTURES WITH MODIFIED BIODEGRADATION KINETICS

Applicant/Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 13/144724   Filing Date: 15/Jan/2009

Abstract:

Biodegradation kinetics of biodegradable porous objects, such as porous silicon objects, can be controlled by a molecular weight of polymer chains, such as polyethylene glycol chains, disposed on an outer surface of the object. Provided are biodegradable porous objects, which have their biodegradation kinetics controlled by a molecular weight of the disposed polymer chains. Also provided are methods of making such biodegradable porous objects as well as methods of using such biodegradable porous objects for delivery of active agents, such as therapeutic agents and/or imaging agents.

Priority: WO2009US00239 Applic. Date: 2009-01-15

Inventor: GODIN-VILENTCHOUK BIANA [US]; FERRARI MAURO [US]


Application No.: US20120045484A1  Published: 23/Feb/2012

Title: CALCIUM PHOSPHATE/SULFATE-BASED BONE IMPLANT COMPOSITION

Applicant/Assignee: BIOCOMPOSITES LIMITED

Application No.: 13/241999   Filing Date: 23/Sep/2011

Abstract:

A bone graft composition includes beta-tricalcium phosphate and calcium sulphate and slowly soluble sources of calcium ions and hydroxyl ions.

Priority: GB20010010726 Applic. Date: 2001-05-02; US2009-356357 Applic. Date: 2009-01-20; US2004-476242 Applic. Date: 2004-03-25; WO2002GB01986 Applic. Date: 2002-05-01

Inventor: COOPER JOHN JOSEPH [GB]


Application No.: US20120045504A1  Published: 23/Feb/2012

Title: ORAL DRUG DEVICES AND DRUG FORMULATIONS

Applicant/Assignee:

Application No.: 13/264585   Filing Date: 14/Apr/2010

Abstract:

Compositions containing a drug to be delivered and at least one chemical permeation enhancer (CPE), and methods of making and using these compositions are described herein. In a preferred embodiment, the compositions contain two or more CPEs which behave in synergy to increase the permeability of the epithelium, while providing an acceptably low level of cytotoxicity to the cells. The concentration of the one or more CPEs is selected to provide the greatest amount of overall potential (OP). Additionally, the CPEs are selected based on the treatment. CPEs that behave primarily by transcellular transport are preferred for delivering drugs into epithelial cells. CPEs that behave primarily by paracellular transport are preferred for delivering drugs through epithelial cells. Also provided herein are mucoadhesive oral dosage forms. In a preferred embodiment, the oral dosage form is a multi-compartmental device, containing (i) a supporting compartment, (ii) drug compartment and (iii) mucoadhesive compartment.

Priority: US2009-169171P Applic. Date: 2009-04-14; WO2010US31047 Applic. Date: 2010-04-14

Inventor: WHITEHEAD KATHRYN [US]; KARR NATALIE [US]; ARORA ANUBHAV [US]; MITRAGOTRI SAMIR [US]


Application No.: US20120045511A1  Published: 23/Feb/2012

Title: THERMOSENSITIVE HEPATITIS B VACCINE

Applicant/Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Application No.: 12/858305   Filing Date: 17/Aug/2010

Abstract:

A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer

a surface antigen of hepatitis B virus (HBsAg)

and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.

Priority:

Inventor: TAO MI-HUA [TW]; CHOU HO-YUAN [TW]; SHEN HSIN-HSIN [TW]; LIN TSAI-YU [TW]


Application No.: US20120045512A1  Published: 23/Feb/2012

Title: METHODS AND SUBSTRATES FOR DIFFERENTIATION OF NEURAL STEM CELLS

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 13/214824   Filing Date: 22/Aug/2011

Abstract:

The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.

Priority: US2010-375627P Applic. Date: 2010-08-20; US2010-379405P Applic. Date: 2010-09-02

Inventor: LEE KI-BUM [US]; SOLANKI ANIRUDDH [US]; SHAH SHREYAS [US]


Application No.: US20120052038A1  Published: 01/Mar/2012

Title: Organosilicones

Applicant/Assignee:

Application No.: 13/249894   Filing Date: 30/Sep/2011

Abstract:

The present application relates to organosilicones and compositions such as consumer products comprising such organosilicones, as well as processes for making and using such organosilicones and such compositions. Such compositions comprising such organosilicones are easier to formulate, and provide more economical and superior care benefits when compared to current silicone containing compositions.

Priority: US201113078167 Applic. Date: 2011-04-01; US2010-320133P Applic. Date: 2010-04-01; US2010-320141P Applic. Date: 2010-04-01; US2010-366270P Applic. Date: 2010-07-21; US2010-383770P Applic. Date: 2010-09-17; US2010-413062P Applic. Date: 2010-11-12

Inventor: PANANDIKER RAJAN KESHAV [US]; ZANNONI LUKE ANDREW [US]; SMITH STEVEN DARYL [US]; MCCHAIN ROBERT JOSEPH [US]; KLUESNER BERNARD WILLIAM [US]; SEGER REBECCA ANN [US]; MENKHAUS JULIE ANN [US]; SNYDER MICHAEL ALBERT [US]; JANSEN JOSEPH HARRY [US]; PEFFLY MARJORIE MOSSMAN [US]


Application No.: US20120053057A1  Published: 01/Mar/2012

Title: Hyperbranched Polyethers for Solubilization of Sparingly Soluble Active Ingredients

Applicant/Assignee: BASF SE

Application No.: 13/222550   Filing Date: 31/Aug/2011

Abstract:

The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising the amphiphile and a sparingly water-soluble active ingredient. It further relates to a process for producing the composition by contacting the amphiphile and the active ingredient, and to the use of the amphiphile for solubilizing a sparingly water-soluble active ingredient in aqueous solutions. The invention also relates to the use of the amphiphile in an agrochemical formulation comprising the amphiphile and a pesticide for controlling phytopathogenic fungi and/or unwanted vegetation and/or unwanted insect or mite infestation and/or for regulating the growth of plants, and finally to plant propagation material comprising the amphiphile.

Priority: US2010-378951P Applic. Date: 2010-09-01

Inventor: CRISTADORO ANNA [DE]; TUERK HOLGER [DE]; ISHAQUE MICHAEL [DE]; AL-HELLANI RABIE [DE]


Application No.: US20120053619A1  Published: 01/Mar/2012

Title: HEMOSTATIC COMPOSITIONS AND METHODS OF MAKING AND USING SAME

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 12/872308   Filing Date: 31/Aug/2010

Abstract:

The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.

Priority:

Inventor: SCHEWE SCOTT [US]; WARNER ROBERT [US]; WEBER JAN [NL]; ARNEY MICHAEL [US]


Application No.: US20120058062A1  Published: 08/Mar/2012

Title: TWO COMPONENT INTERACTIVE EMULSION PRODUCT

Applicant/Assignee: CARSON PRODUCT DEVELOPMENT, INC

Application No.: 13/276445   Filing Date: 19/Oct/2011

Abstract:

The present invention describes, in one aspect, the use of two oppositely charged surfactants as the primary emulsifiers in two separated parts of a product. The emulsifiers are chosen such that when the two parts of the emulsion product are mixed, the emulsifiers react to form water insoluble compounds that are no longer able to function as emulsifiers, thus, the oil phase of the emulsion is precipitated onto the skin along with the emulsifier reaction product. Since none of the deposited materials are water soluble, or capable of functioning as emulsifiers, the deposited oil phase is extremely resistant to being washed off. This technology finds applications in hand and body creams and lotions, baby care products, sunscreens, skin protective products, makeup systems, and automotive and furniture polishes.

Priority: WO2010US31707 Applic. Date: 2010-04-20; US2009-214211P Applic. Date: 2009-04-21

Inventor: CARSON JOHN C [US]


Application No.: US20120058073A1  Published: 08/Mar/2012

Title: 2-OXASPIRO[5.5]UNDEC-8-ENE Derivatives Useful in Fragrance Compositions

Applicant/Assignee:

Application No.: 13/265937   Filing Date: 28/Apr/2010

Abstract:

Disclosed are substituted 2-oxaspiro[5.5]undec-8-ene derivatives of formula (I) and their use as odorants. This disclosure relates furthermore to a method of their production and flavour and fragrance compositions comprising them.

Priority: WO2010EP55711 Applic. Date: 2010-04-28; US2009-173630P Applic. Date: 2009-04-29

Inventor: GOEKE ANDREAS [CH]; ZOU YUE [CN]


Application No.: US20120058158A1  Published: 08/Mar/2012

Title: Sublingual Pharmaceutical Composition Comprising a Neutral Oil

Applicant/Assignee: LONDONPHARMA LTD

Application No.: 13/265825   Filing Date: 23/Apr/2010

Abstract:

The invention provides pharmaceutical compositions for the sublingual delivery of medicaments comprising a neutral oil and a medicament soluble in said oil, providing that said medicament is not nitroglycerine. The invention also provides delivery devices adapted for sublingual delivery of such compositions.

Priority: GB20090006977 Applic. Date: 2009-04-23; WO2009GB50416 Applic. Date: 2009-04-23; WO2010GB50671 Applic. Date: 2010-04-23

Inventor: BOOLES CLIVE [GB]


Application No.: US20120058165A1  Published: 08/Mar/2012

Title: Opacifying Lotion

Applicant/Assignee:

Application No.: 13/220982   Filing Date: 30/Aug/2011

Abstract:

A lotion for opacifying a wet wipe. A wet wipe may comprise a lotion, the lotion comprising an opacifying agent. The lotion or the substrate may further comprise a retention aid. The substrate may comprise an opacifying agent the same as or different than the opacifying agent of the lotion. A method for opacifying a wet wipe by loading onto a wipe substrate a lotion comprising an opacifying agent. A method for aesthetically modifying a wet wipe by selectively loading onto a wipe substrate a lotion comprising an opacifying agent.

Priority: US2010-378096P Applic. Date: 2010-08-30

Inventor: KLOFTA THOMAS JAMES [US]; MILLER KRISTIN HOFMANN [US]; BONAUER CHRISTOPH HANS PETER [DE]; AZIZ SAMIR M [US]; SHEEHAN ASTRID ANNETTE [US]


Application No.: US20120058187A1  Published: 08/Mar/2012

Title: WATER-IN-OIL TYPE EMULSION FOR TREATING A DISEASE OF THE EYE

Applicant/Assignee: NOVAGALI PHARMA SA

Application No.: 12/875805   Filing Date: 03/Sep/2010

Abstract:

A composition is described herein for administering with a sustained release kinetic a therapeutically effective amount of a therapeutic agent to a subject in need thereof for treating diseases or conditions of the eye, wherein the composition is an water-in-oil type emulsion comprising an oil phase, a lipophilic surfactant dissolved in the oil phase, an aqueous phase dispersed in the oil phase, a hydrophilic therapeutic agent dissolved in the aqueous dispersed phase, and wherein the composition is intraocularly injectable, wherein the composition has a density lower than 1. Some embodiments also relate to a pharmaceutical composition or to a medicament comprising a composition described herein, and to a method for treating a condition or disease of the eye comprising administering a therapeutic amount of a composition described herein.

Priority:

Inventor: LALLEMAND FREDERIC [FR]; GARRIGUE JEAN-SEBASTIEN [FR]


Application No.: US20120058962A1  Published: 08/Mar/2012

Title: BUCCAL AND/OR SUBLINGUAL THERAPEUTIC FORMULATION

Applicant/Assignee: LINGUAL CONSEQNA PTY LTD

Application No.: 13/256844   Filing Date: 20/May/2010

Abstract:

A buccal and/or sublingual formulation comprising one or more active compounds

and a buccal matrix which releases the active compounds at a predetermined rate for transport across the buccal and/or sublingual membranes, wherein the rate of release of the active compounds is either (A) the same or substantially the same rate at which the active compounds are transported across the buccal and/or sublingual membranes

or (B) a rate which releases the active compounds over an extended period as required by the therapeutic affect or treatment window for those active compounds.

Priority: AU20090902280 Applic. Date: 2009-05-20; WO2010AU00594 Applic. Date: 2010-05-20

Inventor: CUMMING ALISTAIR [AU]; SPARROW LANCE [AU]; KANNAR DAVID [AU]


Application No.: US20120064011A1  Published: 15/Mar/2012

Title: PREPARATION FOR EXTERNAL APPLICATION

Applicant/Assignee: BUBBLES AND BEYOND GMBH

Application No.: 13/257100   Filing Date: 19/Mar/2010

Abstract:

Preparations for external application to human and animal skin, comprising: a) a composition in the form of a fluid nanophase system, comprising the components of a1) at least one water-insoluble substance with a water solubility of less than 4 gram per liter, a2) at least one amphiphilic substance (NP-MCA), which has no surfactant structure, does not build structures alone, the solubility of which is between 4 g and 1000 g per liter in water or oil and which does not enrich preferably at the oil-water interface, a3) at least one anionic, cationic, amphoteric and/or non-ionic surfactant, a4) at least one polar protic solvent, in particular having hydroxy functionality, a5) if necessary one or more adjuvants, wherein the percentage relate to the total weight of the composition each

and b) a therapeutic, cosmetic or diagnostically effective agent in a therapeutic, cosmetic or diagnostically effective amount.

Priority: DE200910013469 Applic. Date: 2009-03-19; WO2010EP01742 Applic. Date: 2010-03-19

Inventor: SCHUMANN DIRK [DE]


Application No.: US20120064013A1  Published: 15/Mar/2012

Title: FOAMABLE TOPICAL COMPOSITION

Applicant/Assignee:

Application No.: 13/226761   Filing Date: 07/Sep/2011

Abstract:

A foamable composition for topical application, the composition comprising a water in oil emulsion which is devoid of gelling agents.

Priority: WO2010IL00096 Applic. Date: 2010-02-03; US2010-382648P Applic. Date: 2010-09-14; US2010-382888P Applic. Date: 2010-09-14

Inventor: MARCOS DAVID [IL]; HARAN MILANE [IL]


Application No.: US20120064022A1  Published: 15/Mar/2012

Title: CYCLOSILOXANE-SUBSTITUTED POLYSILOXANE COMPOUNDS, COMPOSITIONS CONTAINING THE COMPOUNDS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 13/198658   Filing Date: 04/Aug/2011

Abstract:

Provided herein are cyclosiloxane-substituted polysiloxane compounds, compositions that include the polysiloxane compounds, and methods for preparation and use of the polysiloxane compounds. Provided are mechanical lubricant compositions, hydraulic fluid compositions, anti-foam compositions, water repellant agent compositions, release agent compositions, personal care compositions, cosmetic compositions, household care compositions and drug delivery compositions that include one or more of the cyclosiloxane-substituted polysiloxane compounds provided herein.

Priority: US2010-371079P Applic. Date: 2010-08-05

Inventor: WRAY DANIEL X [US]; HALSDORFF MICHAEL B [US]; DE ARMOND ROBERT L [US]


Application No.: US20120064134A1  Published: 15/Mar/2012

Title: COLOR ENHANCEMENT UTILIZING UP CONVERTERS AND DOWN CONVERTERS

Applicant/Assignee: IMMUNOLIGHT, LLC

Application No.: 13/204355   Filing Date: 05/Aug/2011

Abstract:

A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.

Priority: US2010-371549P Applic. Date: 2010-08-06

Inventor: BOURKE JR FREDERIC J [US]; WALDER HAROLD [US]


Application No.: US20120064135A1  Published: 15/Mar/2012

Title: Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof

Applicant/Assignee: NORAC PHARMA

Application No.: 13/210855   Filing Date: 16/Aug/2011

Abstract:

The present invention relates to the preparation of compositions comprising benzoyl peroxide, with or without other additional active ingredients. The process involves introducing benzoyl peroxide, along with any other active ingredients present, into a fatty substance that contains and protects the ingredients that would otherwise be unstable when in contact with one another. The composition is designed to allow all ingredients to become available for skin contact or skin absorption when the fatty substance softens and/or melts as the composition is applied to the skin. The benzoyl peroxide may be pre-micronized to a particle distribution size of about d90 of 0.1 to 150 microns, preferably d90 of 10 to 15 microns. Further, pharmaceutical or cosmetic ingredients may be contained within the fatty substances, with or without, benzoyl peroxide therein or may be present outside of the fatty substance but elsewhere within formulated pharmaceutical or cosmetic products using the active ingredients protected by the fatty substance. These compositions are useful in aqueous-based formulations to treat diseases by topical, transdermal and/or subcutaneous administration.

Priority: US2010-389456P Applic. Date: 2010-10-04; US2010-383149P Applic. Date: 2010-09-15

Inventor: LEVIN DANIEL [US]; HARMS ARTHUR [US]


Application No.: US20120064142A1  Published: 15/Mar/2012

Title: POLYMERIC PHARMACEUTICAL DOSAGE FORM IN SUSTAINED RELEASE

Applicant/Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG

Application No.: 13/131820   Filing Date: 30/Nov/2009

Abstract:

This invention relates to a polymeric pharmaceutical dosage form for the delivery, in use, of at least one pharmaceutical composition in a rate-modulated and site-specific manner. The dosage form comprises a biodegradable, polymeric, scaffold incorporating loaded with at least one active pharmaceutical ingredient (API). The polymer or polymers making up the scaffold degrade in a human or animal body in response to or in the absence of specific biological stimuli and, on degradation, release the API or APIs in an area where said stimuli are encountered. Preferably the polymeric scaffold is formed from poly (D1L-lactide) (PLA) and polymethacrylate (Eudragit S100/ES100) polymers.

Priority: WO2009IB07598 Applic. Date: 2009-11-30; ZA20080005625 Applic. Date: 2008-11-30; ZA20080005626 Applic. Date: 2008-11-30

Inventor: PILLAY VINESS [ZA]; CHOONARA YAHYA ESSOP [ZA]; SIBEKO BONGANI [ZA]; HARILALL SHERI-LEE [ZA]; PILLAY SAMATHA [ZA]; MODI GIRISH [ZA]; IYUKE SUNNY ESAYEGBEMU [ZA]; NAIDOO DINESH [ZA]


Application No.: US20120064146A1  Published: 15/Mar/2012

Title: Wound care device

Applicant/Assignee: COLOPLAST A/S

Application No.: 13/230479   Filing Date: 12/Sep/2011

Abstract:

A wound care device for local treatment of pain in a wound, said device comprising an active pain relieving composition, the device being constructed in such a manner that the pain killing agent is released to the wound in such a way that substantially no effective systemic plasma concentration of the pain killing agent can be found and wherein a majority of said pain killing agent is in direct contact with the wound.

Priority: DK20030000920 Applic. Date: 2003-06-19; US2005-560181 Applic. Date: 2005-12-09; WO2004DK00427 Applic. Date: 2004-06-18

Inventor: FRIIS GITTE JUEL [DK]; LARSEN TRUELS STERM [DK]


Application No.: US20120064147A1  Published: 15/Mar/2012

Title: AGENT FOR IMPROVING TISSUE PENETRATION

Applicant/Assignee: GENZYME CORPORATION, MAX-PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSHAFTEN E.V

Application No.: 13/089562   Filing Date: 19/Apr/2011

Abstract:

The invention concerns a pharmaceutical preparation which improves penetration of active substances through the tissue membrane or barrier of the target organ.

Priority: DE20011022855 Applic. Date: 2001-05-11; WO2002EP05242 Applic. Date: 2002-05-13; US2009-357003 Applic. Date: 2009-01-21; US2007-716669 Applic. Date: 2007-03-12; US2003-477562 Applic. Date: 2003-11-12

Inventor: EIBL HANS-JORG [DE]; HOFFMANN PETER [US]


Application No.: US20120064163A1  Published: 15/Mar/2012

Title: ANTI-TUMOR/CANCER HETEROLOGOUS ACELLULAR COLLAGENOUS PREPARATIONS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/880936   Filing Date: 13/Sep/2010

Abstract:

Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer.

Priority:

Inventor: SUCKOW MARK A [US]; HILES MICHAEL C [US]


Application No.: US20120064164A1  Published: 15/Mar/2012

Title: EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS

Applicant/Assignee: INVENTIA HEALTHCARE PRIVATE LIMITED

Application No.: 13/321154   Filing Date: 20/May/2010

Abstract:

The present invention provides extended release pharmaceutical compositions structured for once a day administration comprising skeletal muscle relaxant such as cyclobenzaprine or its pharmaceutically acceptable salt thereof that extends the release of the drug under in-vitro conditions for at least 8 to 12 hours. The invention also provides process for the preparation of such structured compositions.

Priority: IN2009MU01287 Applic. Date: 2009-05-22; WO2010IB01229 Applic. Date: 2010-05-20

Inventor: JAISWAL SUNIL BEHARILAL [IN]; SHAH VAIBHAVI ANKUR [IN]; TIWARI SUNIL DEVIPRASAD [IN]


Application No.: US20120065060A1  Published: 15/Mar/2012

Title: SEED COATING COMPOSITION

Applicant/Assignee:

Application No.: 13/138636   Filing Date: 17/Mar/2010

Abstract:

The invention is directed to a seed coating composition, to a seed coating cocktail, to a method for preparing a coated seed, to a coated seed, and to the use of specific inorganic particles. The seed coating composition for a seed comprises water and at least 35 wt. % by weight of the coating composition of inorganic particles, wherein the mean particle size (D50) of said inorganic particles as measured by laser obscuration time technology is 250 [mu]m or less.

Priority: EP20090155415 Applic. Date: 2009-03-17; WO2010NL50140 Applic. Date: 2010-03-17

Inventor: REUS HENRICUS A M [NL]; GLAS JANTIEN [NL]


Application No.: US20120065274A1  Published: 15/Mar/2012

Title: AZEOTROPE-LIKE COMPOSITIONS COMPRISING 1-CHLORO-3,3,3-TRIFLUOROPROPENE

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 13/298452   Filing Date: 17/Nov/2011

Abstract:

An azeotrope-like mixture consisting essentially of chlorotrifluoropropene and at least one component selected from the group consisting of a C1-C3 alcohol, a C5-C6 hydrocarbon, a halogenated hydrocarbon, methylal, methyl acetone, water, nitromethane, and combinations thereof.

Priority: US2008-109007P Applic. Date: 2008-10-28; US2008-259694 Applic. Date: 2008-10-28; US2009-605609 Applic. Date: 2009-10-26

Inventor: BASU RAJAT [US]; BEMENT LESLIE [US]; COOK KANE [US]; HULSE RYAN [US]; KNOPECK GARY [US]; PHAM HANG T [US]; SINGH RAJIV R [US]; WILLIAMS DAVID J [US]


Application No.: US20120070380A1  Published: 22/Mar/2012

Title: Ingestible salt grabber

Applicant/Assignee: ELWHA LLC, A LIMITED LIABILITY COMPANY OF THE STATE OF DELAWARE

Application No.: 12/924212   Filing Date: 21/Sep/2010

Abstract:

Disclosed herein include embodiments related to compositions, devices, computer systems, computer-implemented methods, and computer program products associated with an ingestible salt grabber.

Priority:

Inventor: HYDE RODERICK A [US]; KINDSVOGEL WAYNE R [US]; MCKNIGHT GARY L [US]; WOOD JR LOWELL L [US]


Application No.: US20120070388A1  Published: 22/Mar/2012

Title: CLEANING COMPOSITIONS AND EMULSIONS OR MICROEMULSIONS EMPLOYING EXTENDED CHAIN NONIONIC SURFACTANTS

Applicant/Assignee: ECOLAB USA INC

Application No.: 12/884638   Filing Date: 17/Sep/2010

Abstract:

The invention discloses synergistic combinations extended chain surfactants and co-surfactants, emulsions or microemulsions and cleaning compositions incorporating the same. In certain embodiments a surfactant system is disclosed which includes extended nonionic surfactants, and a linker surfactant. This system forms stable emulsions or microemulsions with oils, including non-trans fats and fatty acids and these emulsions or microemulsions are stable, irreversible and can be created at low temperature. The cleaning compositions may include the surfactant system alone, a stable emulsion or microemulsion with oil and the surfactant system, a pre-spotter or other pre-treatment or soft surface and hard surface cleaning compositions comprising the surfactant combination.

Priority:

Inventor: MAN VICTOR FUK-PONG [US]; KILLEEN YVONNE MARIE [US]; LENTSCH STEVEN EUGENE [US]; DENOMA MICHAEL CHARLES [US]


Application No.: US20120070483A1  Published: 22/Mar/2012

Title: Multi-Functional Biocompatible Coatings for Intravascular Devices

Applicant/Assignee:

Application No.: 13/093090   Filing Date: 25/Apr/2011

Abstract:

A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.

Priority: US2004-924102 Applic. Date: 2004-08-23

Inventor: ZHOU ZHENGRONG [US]; MEYERHOFF MARK E [US]; REYNOLDS MELISSA M [US]


Application No.: US20120071510A1  Published: 22/Mar/2012

Title: Method and Composition for Treating Migraines

Applicant/Assignee: MANNKIND CORPORATION

Application No.: 13/293017   Filing Date: 09/Nov/2011

Abstract:

A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.

Priority: US2010-412339P Applic. Date: 2010-11-10; US2007-982368P Applic. Date: 2007-10-24; US2007-985620P Applic. Date: 2007-11-05; US2008-022274P Applic. Date: 2008-01-18; US2008-033740P Applic. Date: 2008-03-04; US2008-052127P Applic. Date: 2008-05-09; US2008-094823P Applic. Date: 2008-09-05; US2010-411775P Applic. Date: 2010-11-09; US2010-357039P Applic. Date: 2010-06-21; US2008-258341 Applic. Date: 2008-10-24; WO2011US41303 Applic. Date: 2011-06-21

Inventor: LEONE-BAY ANDREA [US]; STOWELL GRAYSON W [US]; GUARNERI JOSEPH J [US]; CARLSON DAWN M [US]; GRANT MARSHALL [US]; SMUTNEY CHAD C [US]


Application No.: US20120071568A1  Published: 22/Mar/2012

Title: Cosmetic Composition

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 13/321245   Filing Date: 19/May/2010

Abstract:

An object of the invention is to provide a cosmetic composition that is not drippy during makeup removal, has good skin spreadability during use, has a refreshing feeling in use, and provides a high cleansing effect, and in particular, to provide a cleansing composition. The cosmetic composition according to the invention is characterized by comprising (A) an alkyl ethylene oxide surfactant having an HLB of 8 to 13, (B) 10 to 40 mass % of an oil component, and (C) water, wherein the composition is a discontinuous-micellar cubic liquid-crystal phase. Also the cosmetic composition is characterized by comprising the above composition as the outer phase and (B2) an oil phase comprising an oil component, that is different from the oil component (B1) captured in said discontinuous-micellar cubic liquid-crystal phase, as the inner phase.

Priority: WO2010JP58479 Applic. Date: 2010-05-19; JP20090120828 Applic. Date: 2009-05-19; JP20090120829 Applic. Date: 2009-05-19

Inventor: SUGIYAMA YUKI [JP]; WATANABE KEI [JP]; NISHIJIMA YOSHIHITO [JP]


Application No.: US20120071865A1  Published: 22/Mar/2012

Title: FLOWABLE HYDROGELS FOR CONTROL OF CELL IN-MIGRATION

Applicant/Assignee:

Application No.: 12/884466   Filing Date: 17/Sep/2010

Abstract:

Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages.

Priority:

Inventor: JARRETT PETER [US]; HAYEK RAMI EL [US]; BASSETT MICHAEL [US]; BIGGINS JAMES [US]


Application No.: US20120076733A1  Published: 29/Mar/2012

Title: POST-BIOPSY CAVITY TREATMENT IMPLANTS AND METHODS

Applicant/Assignee:

Application No.: 13/309504   Filing Date: 01/Dec/2011

Abstract:

A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix defining a first controlled pore architecture. The shell portion is coupled to the core portion and includes a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture.

Priority: US2010-806890 Applic. Date: 2010-08-23; US2008-256619 Applic. Date: 2008-10-23; US2008-018170 Applic. Date: 2008-01-22; US2003-688289 Applic. Date: 2003-10-16; US2003-627960 Applic. Date: 2003-07-25

Inventor: CHERNOMORSKY ARY S [US]; VETTER JAMES W [US]; CHERNOMORSKY SIMON [US]


Application No.: US20120076742A1  Published: 29/Mar/2012

Title: Topical drug delivery system with dual carriers

Applicant/Assignee:

Application No.: 13/066711   Filing Date: 21/Apr/2011

Abstract:

A topical drug delivery system for use as a self-medication delivery system, formed as a multi-functional hygroscopic solution comprising a non-hygroscopic first chemical penetration enhancer, a hygroscopic second chemical penetration enhancer and an anti-oxidizing dispersant mixable in solution with the first and second chemical penetration enhancers and an active pharmaceutical ingredient, said dispersant being in a weight percent of the solution of between 3% and 10% and being suitable for providing multiple secondary therapeutic effects by interaction with the active pharmaceutical ingredient to ensure substantial homogenous distribution of the selected active pharmaceutical ingredient in the solution during delivery of the solution to all areas of the mammalian tissue location and by further reducing the water activity level of the solution.

Priority: US2010-455888P Applic. Date: 2010-10-28; US2010-403712P Applic. Date: 2010-09-20; US2010-342954P Applic. Date: 2010-04-21

Inventor: PHILLIPS D HOWARD [US]; KEOUGH STEVEN [US]


Application No.: US20120076845A1  Published: 29/Mar/2012

Title: SALINE NOSE WIPE AND METHODS OF MANUFACTURE AND USE

Applicant/Assignee: LITTLE BUSY BODIES, INC

Application No.: 13/308502   Filing Date: 30/Nov/2011

Abstract:

The present invention generally relates to a wet wipe or sheet that is suitable for contacting the skin and removing mucus from the skin. More specifically, the present invention relates to a wet wipe having an aqueous saline component suitable for dissolving and removing mucus in combination with the fabric matrix of the wet wipe. Typically, the fabric matrix of the wet wipe has a capacity of about 125 grams of solution per square meter, and it is impregnated with the aqueous saline solution to a level at or below approximately 80% of the absorbent capacity of the matrix.

Priority: US2010-950694 Applic. Date: 2010-11-19; US2008-228426 Applic. Date: 2008-08-11; US2007-964327P Applic. Date: 2007-08-10

Inventor: DONEY MINDEE K [US]; PICKENS JULIENNE M [US]


Application No.: US20120076852A1  Published: 29/Mar/2012

Title: DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 13/249072   Filing Date: 29/Sep/2011

Abstract:

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent

a drug delivery method with the use of the same

a drug containing the same

and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier.

Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

Priority: JP20040382791 Applic. Date: 2004-12-22; US2008-793736 Applic. Date: 2008-04-08; WO2005JP23619 Applic. Date: 2005-12-22

Inventor: NIITSU YOSHIRO [JP]; KATO JUNJI [JP]; SATO YASUSHI [JP]


Application No.: US20120076858A1  Published: 29/Mar/2012

Title: Orally Disintegrating Dosage Forms Containing Taste-Masked Active Ingredients

Applicant/Assignee: BASF SE

Application No.: 13/375611   Filing Date: 31/May/2010

Abstract:

Orally disintegrating dosage forms, for the purpose of masking the taste, comprise active ingredients coated with a cationic polymer are described. The coating of polymers comprises N,N-diethylaminoethyl methacrylate (DEAEMA) polymerized therein. The taste-masked active ingredients are embedded into an orally disintegrating matrix.

Priority: EP20090161910 Applic. Date: 2009-06-04; WO2010EP57515 Applic. Date: 2010-05-31

Inventor: KOLTER KARL [DE]; ANGEL MAXIMILIAN [DE]


Application No.: US20120077885A1  Published: 29/Mar/2012

Title: GELLING AGENT AND GEL

Applicant/Assignee:

Application No.: 13/376053   Filing Date: 31/May/2010

Abstract:

A compound represented by the following formula (1) is provided as a gelling agent for gelatinizing a liquid organic compound: wherein n and m are each independently an integer of 2 to 18, R1 and R3 are each independently a single bond or a branched or linear alkylene group having 1 to 6 carbon atoms, R2 is a branched or linear alkylene group having 3 to 18 carbon atoms, and Z1 and Z2 are each independently a phenylene group or a biphenylene group.

Priority: WO2010JP59578 Applic. Date: 2010-05-31; JP20090134774 Applic. Date: 2009-06-04

Inventor: OKAMOTO HIROAKI [JP]; MORITA YUKI [JP]


Application No.: US20120082632A1  Published: 05/Apr/2012

Title: Topical drug delivery system with dual carriers

Applicant/Assignee:

Application No.: 13/066704   Filing Date: 21/Apr/2011

Abstract:

A drug delivery system, formed as a tissue penetrating solution, comprising: a solvent suitable for solubilizing a non-liquid active ingredient into a solution

a diluent for diluting the solvent to optimize the solution for mammalian tissue compatibility

and a stabilizer for maintaining the solution chemically stable and substantially free from oxidation during storage for a pre-determined shelf life period.

Priority: US2010-455888P Applic. Date: 2010-10-28; US2010-403712P Applic. Date: 2010-09-20; US2010-342954P Applic. Date: 2010-04-21

Inventor: PHILLIPS D HOWARD [US]; KEOUGH STEVEN [US]


Application No.: US20120082709A1  Published: 05/Apr/2012

Title: COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS

Applicant/Assignee: LANDEC CORPORATION

Application No.: 13/377566   Filing Date: 11/Jun/2010

Abstract:

Compositions for delivering release materials, for example drugs, agricultural materials, other bioactive materials, cosmetic materials, organic or inorganic compounds which take part in or catalyse a chemical reaction, a fragrance-emitting material for a vaporizer, or a lubricating material. The release material is associated with a crystalline carrier. The carrier may be a crystalline polymer containing a plurality of crystalline groups or a crystalline monomer which contains a single crystalline group, the crystalline group preferably comprising a straight chain polymethylene radical containing at least 16 carbon atoms. Some of the carriers are obtained by modifying hyaluronic acid, collagen, gelatin, a polysaccharide, a carbohydrate or cyclodextran. The release material may contain a similar crystalline group, for example may be an active compound which has been modified to introduce a crystalline group.

Priority: US2009-268329P Applic. Date: 2009-06-11; WO2010US38239 Applic. Date: 2010-06-11

Inventor: TAFT DAVID D [US]; BITLER STEPHEN P [US]; ZHENG QIANG [US]; BALANCHANDER NATARAJAN [US]; OTTENSMAN SANDRA N [US]


Application No.: US20120082714A1  Published: 05/Apr/2012

Title: TRANSDERMAL THERAPEUTIC SYSTEM WITH CRYSTALLIZATION-INHIBITING PROTECTIVE FILM (RELEASE LINER)

Applicant/Assignee: BAYER PHARMA AKTIENGESELLSCHAFT

Application No.: 13/225660   Filing Date: 06/Sep/2011

Abstract:

The invention relates to pharmaceutical formulations, in particular to transdermal therapeutic systems, which are characterized in that little or no active ingredient crystallizes out at the interface between the removable protective film (release liner) and the active-ingredient-containing matrix.

Priority: DE201010040299 Applic. Date: 2010-09-06

Inventor: BRACHT STEFAN [DE]; TEREBESI ILDIKO [DE]; LANGGUTH THOMAS [DE]


Application No.: US20120082724A1  Published: 05/Apr/2012

Title: DRY MOULDABLE DRUG FORMULATION

Applicant/Assignee: NOVO NORDISK A/S

Application No.: 13/285470   Filing Date: 31/Oct/2011

Abstract:

Solid pharmaceutical compositions for parenteral injection comprising a binder and at least one therapeutic agent. The pharmaceutical composition has the strength to be injected directly with the need of using cannulas or the like.

Priority: US1999-139403P Applic. Date: 1999-06-14; US2000-550857 Applic. Date: 2000-04-17; US2005-052645 Applic. Date: 2005-02-07; US2009-462794 Applic. Date: 2009-08-07; DK19990000514 Applic. Date: 1999-04-16

Inventor: BUCH-RASMUSSEN THOMAS [DK]; AASMUL SOEREN [DK]; FLINK JAMES M [DK]; HANSEN PHILIP [DK]; POULSEN JENS ULRIK [DK]; JUUL-MORTENSEN CLAUS [DK]


Application No.: US20120083444A1  Published: 05/Apr/2012

Title: Emulsion Method For Preparing Low Residual Solvent Microparticles

Applicant/Assignee:

Application No.: 13/247577   Filing Date: 28/Sep/2011

Abstract:

The method disclosed herein comprises using a non-polar alkane in the continuous phase of an emulsion process to aid in the removal of dispersed phase solvent from the microparticles. The microparticles can further be subjected to a post-production treatment process, involving a non-polar alkane suspension and a rinse, to further reduce residual dispersed phase solvent levels.

Priority: US2010-388049P Applic. Date: 2010-09-30

Inventor: PERKINS BRENDA [US]; PATTANAIK ASIMA [US]


Application No.: US20120087857A1  Published: 12/Apr/2012

Title: GADOLINIUM EXPRESSED LIPID NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING

Applicant/Assignee: UNIVERSITY OF WASHINGTON

Application No.: 13/208100   Filing Date: 11/Aug/2011

Abstract:

Lipid nanoparticles expressing metal ions and methods for using the compositions for magnetic resonance imaging.

Priority: WO2010US24324 Applic. Date: 2010-02-16; US2009-152459P Applic. Date: 2009-02-13; US2009-162989P Applic. Date: 2009-03-24

Inventor: HO RODNEY J Y [US]; HOEKMAN JOHN D [US]; MARAVILLA KEN [US]


Application No.: US20120087884A1  Published: 12/Apr/2012

Title: NOVEL 3.2.1-BICYCLO-OCTENE AND -OCTANE COMPOUNDS

Applicant/Assignee:

Application No.: 12/901077   Filing Date: 08/Oct/2010

Abstract:

The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octene and -octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of hydrogen, acetate, carbonate monomethyl ester, and allyloxy

and wherein the broken line represents a single or double bond.

Priority:

Inventor: CLOSSON ADAM P [US]; AMORELLI BENJAMIN [US]; O'KEEFE NICOLE [US]


Application No.: US20120087885A1  Published: 12/Apr/2012

Title: NOVEL 3.2.1-BICYCLO-OCTANE COMPOUNDS

Applicant/Assignee:

Application No.: 12/901097   Filing Date: 08/Oct/2010

Abstract:

The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of carbonyl and [1,3]dioxolane

R' is selected from the group consisting of hydrogen and allyl

or R and R' taken together represent

Priority:

Inventor: CLOSSON ADAM P [US]; AMORELLI BENJAMIN [US]; O'KEEFE NICOLE [US]


Application No.: US20120087980A1  Published: 12/Apr/2012

Title: STIMULATION OF NEUROREGENERATION BY FLAVONOID GLYCOSIDES

Applicant/Assignee:

Application No.: 13/250844   Filing Date: 30/Sep/2011

Abstract:

Flavonoid glycosides, such as isoquercitrin, are shown to stimulate the formation of neuritis and neuronal synapses in neurons and neuronal progenitor (stem) cells.

Priority: US2010-391018P Applic. Date: 2010-10-07

Inventor: ZENOBI-WONG MARCY [CH]


Application No.: US20120088842A1  Published: 12/Apr/2012

Title: METHODS FOR OPTIMIZING ELECTROPORATION

Applicant/Assignee: MAXCYTE, INC

Application No.: 13/147165   Filing Date: 15/Jul/2009

Abstract:

Embodiments of the invention are directed to a technique for electroporation that allows for a delivery of long electrical pulses of high magnitude in highly conductive buffers and minimizes damage to cells undergoing electroporation.

Priority: WO2009US50726 Applic. Date: 2009-07-15; US2008-081924P Applic. Date: 2008-07-18

Inventor: DZEKUNOV SERGEY [US]


Application No.: US20120089110A1  Published: 12/Apr/2012

Title: Absorbent Article with Lotion

Applicant/Assignee:

Application No.: 13/111507   Filing Date: 19/May/2011

Abstract:

An absorbent article, such as a catamenial device, having a liquid pervious topsheet, a backsheet joined to the topsheet, and an absorbent core disposed between the topsheet and the backsheet is disclosed. The absorbent article has a lotion composition applied to at least a portion of the outer surface of the topsheet, the lotion composition including a rheology structurant selected from the group consisting of microcrystalline wax, alkyl dimethicone, ethylene glycol dibehenate, ethylene glycol distearate, glycerol tribehenate, glycerol tristearate, and ethylene bisoleamide.

Priority: US2010-391254P Applic. Date: 2010-10-08

Inventor: PAN ROBERT YA-LIN [US]; EBERT DEBORA CHRISTINE [US]; ELLINGSON PETER CHRISTOPHER [US]; WARREN RAPHAEL [US]


Application No.: US20120093771A1  Published: 19/Apr/2012

Title: METHOD FOR PREPARING A HARDENED CALCIUM SULFATE DIHYDRATE BLOCK AND USE THEREOF

Applicant/Assignee: NATIONAL CHENG KUNG UNIVERSITY

Application No.: 12/907104   Filing Date: 19/Oct/2010

Abstract:

The present invention provides a technique for prolonging the working time and setting time of a calcium sulfate hemihydrate paste by mixing calcium sulfate hemihydrate powder with an aqueous solution containing phosphate ions, so that the paste is suitable for operation and the resultant hardened calcium sulfate dihydrate block from the paste has an improved mechanical strength.

Priority:

Inventor: LIN JIIN-HUEY CHERN [US]; JU CHIEN-PING [US]


Application No.: US20120093803A1  Published: 19/Apr/2012

Title: MEANS AND METHODS OF STERILIZATION OF BIOFUNCTIONAL COMPOSITIONS

Applicant/Assignee: LEUKOCARE AG

Application No.: 13/262387   Filing Date: 31/Mar/2010

Abstract:

The present invention, inter alia, relates to a closed sterilized container comprising at least one carrier which is a stabilizer

and at least one biomolecule reversibly attached to the carrier, wherein said carrier partially or completely covers the attached biomolecules and wherein said at least one carrier is selected from the group consisting of (poly)peptides such as dipeptides or tripeptides, amino acids, polyalcohols, polyethyleneglycols, ionic liquids, compatible solutes, saponins and a mixture thereof. The invention also relates to methods for producing sterilized containers according to the invention and uses thereof.

Priority: EP20090004735 Applic. Date: 2009-03-31; WO2010EP54390 Applic. Date: 2010-03-31

Inventor: ALTRICHTER JENS [DE]; BREUER ANJA [DE]; SCHAATH NICOLE [DE]; QUATHAMER JULIA [DE]


Application No.: US20120093902A1  Published: 19/Apr/2012

Title: FLUID RESERVOIR

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 13/329548   Filing Date: 19/Dec/2011

Abstract:

Fluid reservoirs which are based on polymer substrates and are capable of storing large amounts of fluids. The storage is reliable and the reemergence from the liquid reservoir is readily controllable, for example, via the temperature or via mechanical actions, to achieve retardation of the fluid release. Also, processes for producing such fluid reservoirs and also their use, for example in washing or cleaning compositions.

Priority: DE200610005988 Applic. Date: 2006-02-08; DE200610021553 Applic. Date: 2006-05-08; US2008-188628 Applic. Date: 2008-08-08; WO2006EP12096 Applic. Date: 2006-12-15

Inventor: ARTIGA-GONZALEZ RENE-ANDRES [DE]; HARTH HUBERT [DE]; STURM MARIO [DE]; KORBER FRANK [DE]


Application No.: US20120093914A1  Published: 19/Apr/2012

Title: IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PARTICLES AS SCAFFOLDS FOR TISSUE REGENERATION

Applicant/Assignee: MOMA THERAPEUTICS

Application No.: 13/130969   Filing Date: 24/Nov/2009

Abstract:

In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

Priority: US2008-200214P Applic. Date: 2008-11-24; US2008-200213P Applic. Date: 2008-11-24; US2008-200208P Applic. Date: 2008-11-24; US2008-200207P Applic. Date: 2008-11-24; WO2009US65797 Applic. Date: 2009-11-24

Inventor: SCHUBERT SHAI YEHOSHUA [US]


Application No.: US20120093928A1  Published: 19/Apr/2012

Title: ORAL METAXALONE COMPOSITIONS

Applicant/Assignee: RANBAXY LABORATORIES LIMITED

Application No.: 12/672631   Filing Date: 06/Aug/2008

Abstract:

The present invention relates to a pharmaceutical composition comprising low-dose metaxalone and one or more pharmaceutically acceptable polymer, as well as methods of preparing them.

Priority: IN2007DE01699 Applic. Date: 2007-08-09; WO2008IB53168 Applic. Date: 2008-08-06

Inventor: SHEAR RAJESH S [IN]; RATHINASABAPATHY VENKATESHWARAN [IN]; MADAN SUMIT [IN]; ARORA VINOD KUMAR [IN]


Application No.: US20120093929A1  Published: 19/Apr/2012

Title: Opioid Composition for Treating Skin Lesions

Applicant/Assignee: EURO-CELTIQUE S.A

Application No.: 12/991338   Filing Date: 05/May/2009

Abstract:

The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix.

Priority: EP20080155648 Applic. Date: 2008-05-05; WO2009EP55422 Applic. Date: 2009-05-05

Inventor: OKSCHE ALEXANDER [DE]; SMITH KEVIN J [GB]; PRATER DEREK [GB]; WALDEN MALCOLM [GB]; HEATH WILL [GB]; KENNEDY BERNARD [IE]; ADDISON VANESSA [GB]; MOHAMMAD HASSAN [GB]


Application No.: US20120093930A1  Published: 19/Apr/2012

Title: ARTICLE AND METHOD FOR FOCUSED DELIVERY OF THERAPEUTIC AND/OR DIAGNOSTIC MATERIALS

Applicant/Assignee: ARMARK AUTHENTICATION TECHNOLOGIES, LLC

Application No.: 13/337570   Filing Date: 27/Dec/2011

Abstract:

A microfiber extrudate and delivery process includes a bio-compatible polymer matrix forming a body of the microfiber extrudate, an exogenously excitable material arranged within the body, and an active load arranged within the body.

Priority: US2007-017815P Applic. Date: 2007-12-31; US2006-578695 Applic. Date: 2006-10-17; US2008-342830 Applic. Date: 2008-12-23

Inventor: GABRIELE PETER D [US]; FLEMMENS MICHAEL S [US]; ROBERTSON JEFFREY H [US]; HOGAN ANDREW [US]


Application No.: US20120095518A1  Published: 19/Apr/2012

Title: BONE CEMENT FORMULA AND BIORESORBABLE HARDENED BONE CEMENT COMPOSITES PREPARED WITH THE SAME

Applicant/Assignee: NATIONAL CHENG KUNG UNIVERSITY

Application No.: 12/907091   Filing Date: 19/Oct/2010

Abstract:

The present invention provides a bone cement formula having a powder component and a setting liquid component, wherein the powder component includes a calcium sulfate source and a calcium phosphate source with a weight ratio of the calcium sulfate source less than 65%, based on the total weight of the calcium sulfate source and the calcium phosphate source, and the setting liquid component comprises ammonium ion (NH4+) in a concentration of about 0.5 M to 4 M, wherein the calcium phosphate source includes tetracalcium phosphate (TTCP) and dicalcium phosphate in a molar ratio of TTCP to dicalcium phosphate of about 0.5 to about 2.5, and the calcium sulfate source is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), or anhydrous calcium sulfate.

Priority:

Inventor: JU CHIEN-PING [US]; LIN JIIN-HUEY CHERN [US]


Application No.: US20120100077A1  Published: 26/Apr/2012

Title: MIXTURE OF AMPHIPATHIC MOLECULES AND METHOD FOR MODIFYING CELL MEMBRANES BY MEANS OF FUSION

Applicant/Assignee: FORSCHUNGSZENTRUM JUELICH GMBH

Application No.: 13/261122   Filing Date: 08/Jul/2010

Abstract:

Disclosed is a mixture of amphipathic molecules and a method for modifying cells in vivo by way of membrane fusion with these molecules.

Priority: DE200910032658 Applic. Date: 2009-07-09; WO2010DE00811 Applic. Date: 2010-07-08

Inventor: HOFFMANN BERND [DE]; CSISZAR AGNES [DE]; HERSCH NILS [DE]; MERKEL RUDOLF [DE]


Application No.: US20120100119A1  Published: 26/Apr/2012

Title: HYDROLYSIS RESISTANT ORGANOMODIFIED TRISILOXANE SURFACTANTS

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS INC

Application No.: 13/314836   Filing Date: 08/Dec/2011

Abstract:

Three types of trisiloxane surfactants having the basic formula: MDM' are described wherein the substituents on the differing M and M' groups, in conjunction with pendant polyalkylene oxide substituents on the D group render the surfactant resistant to hydrolysis under either basic or acidic conditions outside the pH range of 6.0 to 7.5. The compositions are useful in agricultural, household and cosmetic applications.

Priority: US2006-356607 Applic. Date: 2006-02-17

Inventor: POLICELLO GEORGE A [US]; LEATHERMAN MARK D [US]; PENG WENQING [CN]; RAJARAMAN SURESH K [US]; XIA SOPHIA [CN]


Application No.: US20120100149A1  Published: 26/Apr/2012

Title: Injectable, Non-Aqueous Suspension with High Concentration of Therapeutic Agent

Applicant/Assignee: DURECT CORPORATION

Application No.: 13/282416   Filing Date: 26/Oct/2011

Abstract:

An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

Priority: US2008-020372 Applic. Date: 2008-01-25; US2007-897643P Applic. Date: 2007-01-26

Inventor: HOUSTON PAUL R [US]; CHEN GUOHUA [US]; LUK ANDREW SHEUNG-KING [US]


Application No.: US20120100183A1  Published: 26/Apr/2012

Title: Topical base and active agent-containing compositions, and methods for improving and treating skin

Applicant/Assignee:

Application No.: 12/925464   Filing Date: 23/Oct/2010

Abstract:

The present invention provides unique, efficacious, inexpensive, safe, reliable, convenient, minimally bitter, skin protecting and penetrating, easy-to-administer base compositions and active agent-containing compositions, such as those including hydrocortisone, and related production and topical application methods, for treating the skin of mammals for a wide variety of different dermatologic conditions, disorders and diseases, such as inflammation, redness, cracking, insect bites, dryness, allergic reactions, trauma, irritant dermatitis, perleche, contact dermatitis, psoriasis, eczema, seborrheic dermatitis, acne excoriate, xerosis, eczema craquele, stasis dermatitis, disease related conditions and dryness from medications such as isotretinoin, acitretin and lipid lowering agents. This is effected by topically administering, or otherwise applying, effective amounts of the compositions thereto in forms that not only address the skin and mucosa of the mouth and lips, but also of the rest of the body and, in particular, areas where other topical balms containing hydrocortisone and other active ingredients have not been developed or marketed. Additionally, the flavoring addition to this product, and the base wherein the active ingredient(s) reside, affords a significantly better tasting, and less bitter, composition, thereby allowing a more pleasant experience and better compliance by patients. Larger sized stick formulation(s) allow for more applicability of the product, and more usefulness thereof, in various areas, and mucosal skin, of the body. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in the form of a solid roll-on stick present in a variety of sizes.

Priority:

Inventor: SCHLESSINGER JOEL [US]; SCHLESSINGER DANIEL ISAAC [US]


Application No.: US20120100209A1  Published: 26/Apr/2012

Title: CONTROLLED RELEASE COMPOSITIONS COMPRISING A COMBINATION OF ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LIMITED

Application No.: 13/278787   Filing Date: 21/Oct/2011

Abstract:

The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.

Priority: US2005-262672 Applic. Date: 2005-10-31

Inventor: REKHI GURVINDER SINGH [US]; SIDWELL RICHARD [US]; HAMM SHARON [US]


Application No.: US20120100215A1  Published: 26/Apr/2012

Title: MULLER STEM CELLS

Applicant/Assignee: THE INSTITUTE OF OPHTHALMOLOGY

Application No.: 13/341042   Filing Date: 30/Dec/2011

Abstract:

A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells

and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Müller cells into a progenitor phenotype.

Priority: GB20030028021 Applic. Date: 2003-12-03; US2007-580770 Applic. Date: 2007-05-24; WO2004GB05101 Applic. Date: 2004-12-03

Inventor: LIMB GLORIA ASTRID [GB]; KHAW PENG TEE [GB]


Application No.: US20120100216A1  Published: 26/Apr/2012

Title: MATRIX CARRIER COMPOSITIONS, METHODS AND USES

Applicant/Assignee: OSHADI DRUG ADMINISTRATION LTD

Application No.: 13/381225   Filing Date: 08/Jul/2010

Abstract:

Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.

Priority: US2009-224100P Applic. Date: 2009-07-09; WO2010IL00551 Applic. Date: 2010-07-08

Inventor: VOL ALEXANDER [IL]; GRIBOVA ORNA [IL]


Application No.: US20120100219A1  Published: 26/Apr/2012

Title: COMPOSITION FOR THE PRODUCTION OF TABLETS, AND METHOD FOR THE PRODUCTION OF SAID COMPOSITION

Applicant/Assignee:

Application No.: 13/382957   Filing Date: 07/Jul/2010

Abstract:

The present invention relates to a process for the preparation of a composition for the production of tablets and to a composition obtained thereby. This composition is a directly compressible composition which results both in improved tabletting properties and in improved tablet properties.

Priority: EP20090009065 Applic. Date: 2009-07-10; WO2010EP04135 Applic. Date: 2010-07-07

Inventor: EASSON JAMES [DE]; HAMM WALTER [DE]; MODDELMOG GUENTER [DE]


Application No.: US20120100234A1  Published: 26/Apr/2012

Title: NON-OCCLUDING NASAL MOISTURIZER AND METHODS OF USE

Applicant/Assignee:

Application No.: 13/277310   Filing Date: 20/Oct/2011

Abstract:

Compositions are provided that provide improved nasal moisture, clarity, and lubrication. Compositions are oil-in-glycerin emulsions that include a surfactant promoting emulsification of a hydrophobic or otherwise water insoluble bioactive agent. The compositions are used in methods of promoting improved nasal moisture and reduction in nasal congestion.

Priority: US2010-394998P Applic. Date: 2010-10-20

Inventor: KULESZA JOHN E [US]; KATZ JEFFREY [US]


Application No.: US20120107383A1  Published: 03/May/2012

Title: OSTEOCONDUCTIVE MATRICES COMPRISING CALCIUM PHOSPHATE PARTICLES AND STATINS AND METHODS OF USING THE SAME

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 12/913284   Filing Date: 27/Oct/2010

Abstract:

Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustained release of the statin and facilitate bone formation and repair of the fracture site.

Priority:

Inventor: MCKAY WILLIAM F [US]


Application No.: US20120107401A1  Published: 03/May/2012

Title: OSTEOCONDUCTIVE MATRICES COMPRISING STATINS AND METHODS OF USING THE SAME

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 12/913237   Filing Date: 27/Oct/2010

Abstract:

Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.

Priority:

Inventor: MCKAY WILLIAM F [US]


Application No.: US20120107402A1  Published: 03/May/2012

Title: PROCESS FOR ANALYZING AND ESTABLISHING DOSAGE SIZE IN AN INGESTIBLE FILM

Applicant/Assignee: MONOSOL RX, LLC

Application No.: 12/915849   Filing Date: 29/Oct/2010

Abstract:

The present invention is directed to a method of analyzing and establishing a proper dosage size in ingestible films for providing a more precise dosage delivery of an active ingredient.

Priority:

Inventor: MYERS GARRY [US]; BOGUE BEUFORD A [US]; HARIHARAN MADHU [US]


Application No.: US20120107403A1  Published: 03/May/2012

Title: BLADDER RECONSTRUCTION

Applicant/Assignee: CHILDREN'S MEDICAL CENTER CORPORATION

Application No.: 13/344644   Filing Date: 06/Jan/2012

Abstract:

The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.

Priority: US1997-063790P Applic. Date: 1997-10-31; WO1998US22962 Applic. Date: 1998-10-30; US2000-600455 Applic. Date: 2000-07-17; US2003-394640 Applic. Date: 2003-03-21; US2009-468983 Applic. Date: 2009-05-20

Inventor: ATALA ANTHONY [US]


Application No.: US20120107404A1  Published: 03/May/2012

Title: Crystalline Pharmaceutical and Methods of Preparation and Use Thereof

Applicant/Assignee: SARCODE BIOSCIENCE INC

Application No.: 13/289172   Filing Date: 04/Nov/2011

Abstract:

Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention.

Priority: US2009-386361 Applic. Date: 2009-04-15; US2008-045142P Applic. Date: 2008-04-15

Inventor: BURNIER JOHN [US]; GADEK THOMAS [US]; NAUD FREDERIC [CH]


Application No.: US20120108676A1  Published: 03/May/2012

Title: AEROSOL-MEDIATED PARTICLE SYNTHESIS

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 13/286625   Filing Date: 01/Nov/2011

Abstract:

Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.

Priority: US2010-408850P Applic. Date: 2010-11-01

Inventor: SMYTH HUGH D C [US]; EL-SHERBINY IBRAHIM M [EG]


Application No.: US20120114580A1  Published: 10/May/2012

Title: SPRAYABLE PERFUME WITH AN IMPROVED TENACITY

Applicant/Assignee: FIRMENICH SA

Application No.: 13/352948   Filing Date: 18/Jan/2012

Abstract:

An alcoholic perfume solution with an improved tenacity when applied onto a surface is described. The solution contains an effective amount of a single polymer capable of extending the diffusion of perfuming ingredients in the air.

Priority: WO2004IB01603 Applic. Date: 2004-05-03; EP20030010264 Applic. Date: 2003-05-07; US2005-266060 Applic. Date: 2005-11-02

Inventor: BEAUSSOUBRE PASCAL [FR]; STORA THIERRY [FR]


Application No.: US20120114705A1  Published: 10/May/2012

Title: WATER SOLUBLE FILM FOR ORAL ADMINISTRATION WITH INSTANT WETTABILITY

Applicant/Assignee:

Application No.: 13/292590   Filing Date: 09/Nov/2011

Abstract:

A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.

Priority: DE19961046392 Applic. Date: 1996-11-11; US2004-771388 Applic. Date: 2004-02-05; US2002-143962 Applic. Date: 2002-05-14; US2001-927327 Applic. Date: 2001-08-13; US2000-630562 Applic. Date: 2000-08-02; US1999-287181 Applic. Date: 1999-04-06; US1997-904607 Applic. Date: 1997-08-01

Inventor: ZERBE HORST GEORG [US]; GUO JIAN-HWA [US]; SERINO ANTHONY [US]


Application No.: US20120114716A1  Published: 10/May/2012

Title: Flowable Carrier Matrix

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 13/353632   Filing Date: 19/Jan/2012

Abstract:

A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenetic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.

Priority: US2009-635289 Applic. Date: 2009-12-10; US2006-504363 Applic. Date: 2006-08-14

Inventor: BEALS NEIL B [US]; SCIFERT JEFFREY L [US]; BODEN SCOTT D [US]


Application No.: US20120114717A1  Published: 10/May/2012

Title: TABLETING AGENT HAVING A LOW WATER CONTENT, AND METHOD FOR THE PRODUCTION THEREOF

Applicant/Assignee: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG

Application No.: 13/383061   Filing Date: 07/Jul/2010

Abstract:

The present invention relates to a Tabletting aid with a low water content and to a process for the preparation thereof. The Tabletting aid composition is a directly compressible composition, the use of which results in improved tablet properties.

Priority: EP20090009066 Applic. Date: 2009-07-10; WO2010EP04134 Applic. Date: 2010-07-07

Inventor: EASSON JAMES [DE]; HAMM WALTER [DE]; MODDELMOG GUENTER [DE]


Application No.: US20120114749A1  Published: 10/May/2012

Title: COMPOSITIONS AND METHODS FOR DELIVERY OF EMBOLICS

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 13/350123   Filing Date: 13/Jan/2012

Abstract:

Described herein are compositions comprising one or more embolics attached to an inert, dissolvable matrix as well as kits comprising these novel embolic formulations. Also described are methods of making and using these embolic formulations.

Priority: US2009-381264 Applic. Date: 2009-03-10; US2008-070683P Applic. Date: 2008-03-25

Inventor: O'GARA JOHN [US]; PURI SONALI [US]


Application No.: US20120114750A1  Published: 10/May/2012

Title: PHARMACEUTICAL COMPOSITION 271

Applicant/Assignee: ARRAY BIOPHARMA, INC, ASTRAZENECA AB

Application No.: 13/293368   Filing Date: 10/Nov/2011

Abstract:

The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide and solvates, crystalline forms and amorphous forms thereof, to the use of said compositions as a medicament

and to processes for the preparation of said compositions.

Priority: US2009-411865 Applic. Date: 2009-03-26; US2008-040372P Applic. Date: 2008-03-28

Inventor: BATEMAN NICOLA FRANCES [GB]; GELLERT PAUL RICHARD [GB]; HILL KATHRYN JANE [GB]


Application No.: US20120114754A1  Published: 10/May/2012

Title: RAPIDLY DISINTEGRATING SOLID ORAL DOSAGE FORM

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LTD

Application No.: 13/291873   Filing Date: 08/Nov/2011

Abstract:

Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water-soluble or water-dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, of less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.

Priority: US2003-667470 Applic. Date: 2003-09-23; US2003-276400 Applic. Date: 2003-01-15; WO2001US15983 Applic. Date: 2001-05-18

Inventor: JAIN RAJEEV A [US]; RUDDY STEPHEN B [US]; CUMMING KENNETH IAIN [GB]; CLANCY MAURICE JOSEPH ANTHONY [IE]; CODD JANET ELIZABETH [IE]


Application No.: US20120114755A1  Published: 10/May/2012

Title: METHODS AND MATERIALS FOR TISSUE REPAIR

Applicant/Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Application No.: 13/379299   Filing Date: 22/Jun/2010

Abstract:

This document relates to methods and materials for treating tendon injury. Specifically, methods and materials for preventing adhesion formation and promoting tissue healing following tendon injury and surgical repair are provided.

Priority: US2009-219621P Applic. Date: 2009-06-23; US2009-219144P Applic. Date: 2009-06-22; WO2010US39418 Applic. Date: 2010-06-22

Inventor: AMADIO PETER C [US]; ZHAO CHUNFENG [US]; MORAN STEVEN L [US]; SUN YU-LONG [US]; AN KAI-NAN [US]


Application No.: US20120114756A1  Published: 10/May/2012

Title: SUSTAINED-RELEASE DRUG CARRIER COMPOSITION

Applicant/Assignee: POLYPID LTD

Application No.: 13/383893   Filing Date: 14/Jul/2010

Abstract:

The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a block-co-polymers comprising a non-biodegradable polymer and a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.

Priority: US2009-225289P Applic. Date: 2009-07-14; WO2010IL00563 Applic. Date: 2010-07-14

Inventor: EMANUEL NOAM [IL]; NEUMAN MOSHE [IL]; BARAK SHLOMO [IL]


Application No.: US20120115730A1  Published: 10/May/2012

Title: Agricultural Compositions

Applicant/Assignee: COGNIS IP MANAGEMENT GMBH

Application No.: 13/382567   Filing Date: 29/Jun/2010

Abstract:

Described are agrochemical compositions comprising alkoxylation products according to general formula (I) R1(CO)m-O-[R2O]nR3 (I) wherein R1 is a linear or branched, saturated or unsaturated, optionally hydroxy-functionalised hydrocarbyl radical containing 8 to 30 carbon atoms, R2 is an ethylene, propylene or butylene group or mixtures thereof, R3 is hydrogen or an acyl group containing 1 to 8 carbon atoms, m is 0 or 1, n is an integer between 3 and 100. When R3 is an acyl group, R2 is ethylene, propylene or mixtures thereof, and when R3 is hydrogen, R2 is ethylene, propylene, butylene or mixtures thereof provided that the terminal group represents a butylene oxide unit.

Priority: WO2010EP03936 Applic. Date: 2010-06-29; EP20090008892 Applic. Date: 2009-07-08

Inventor: MAINX HANS-GEORG [DE]; FLEUTE-SCHLACHTER INGO [DE]; BUSCH STEFAN [DE]; HELDT SANDRA [DE]


Application No.: US20120115961A1  Published: 10/May/2012

Title: METAL ORGANIC FRAMEWORK COMPOUNDS

Applicant/Assignee: UNIVERSITETET I OSLO

Application No.: 12/989641   Filing Date: 29/Apr/2009

Abstract:

The invention provides novel Zr MOFs, in particular compounds having a surface area of at least 1020 m2/g or if functionalized, having a surface area of at least 500 m2/g.

Priority: GB20080007862 Applic. Date: 2008-04-29; WO2009GB01087 Applic. Date: 2009-04-29

Inventor: HAFIZOVIC JASMINA [NO]; OLSBYE UNNI [NO]; LILLERUD KARL PETTER [NO]; JACOBSEN SOREN [NO]; GUILLOU NATHALIE [NO]


Application No.: US20120121460A1  Published: 17/May/2012

Title: Detoxicant solution

Applicant/Assignee: OWR AG

Application No.: 11/717323   Filing Date: 13/Mar/2007

Abstract:

A detoxicant solution includes 0.1 to 50 parts by weight of at least one Friedel-Crafts reagent (Lewis acids) (I)

0.5 to 80 parts by weight of one or more of the following specific solvents (II): dimethyl sulfoxide, 1,3-dimethyl-2-imidazolidinone or octamethylcyclotetrasiloxane

and 1 to 80 parts by weight of an alcoholic solvent (III). The term "parts by weight" relates in each case to 100 parts by weight of the complete detoxicant solution.

Priority: DE200410044621 Applic. Date: 2004-09-13; WO2005EP09445 Applic. Date: 2005-09-02

Inventor: HOFFMANN KLAUS [DE]


Application No.: US20120121666A1  Published: 17/May/2012

Title: COMPOSITIONS OF PARTICLES

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 13/357083   Filing Date: 24/Jan/2012

Abstract:

Method of making particle compositions exhibiting improved floodability and/or flowability properties. The compositions generally contain particles and non-surface modified nanoparticles.

Priority: US2009-605849 Applic. Date: 2009-10-26; US2006-615516 Applic. Date: 2006-12-22

Inventor: BARAN JR JIMMIE R [US]; SHINBACH MADELINE P [US]


Application No.: US20120121706A1  Published: 17/May/2012

Title: PAR-1 Activation by Metalloproteinase-1 (MMP-1)

Applicant/Assignee: TUFTS MEDICAL CENTER, INC

Application No.: 13/263715   Filing Date: 12/Apr/2010

Abstract:

Matrix metalloproteases (MMPs) play many important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis and cancer. This invention relates to the activation of protease-activated receptor-1 (PAR-1) by endogenous platelet MMP-1 collagenase on the surface of platelets. Exposure of platelets to fibrillar collagen converts the surface-bound pro-MMP-1 zymogen to active MMP-1, which promotes aggregation through PAR-1, MMP-1 is shown to cleave the PAR-1 extracellular domain at a novel site, which then strongly activates Rho-GTP signaling pathways, cell shape change and motility, and MAPK signaling. Blockade of MMP-PAR 1 suppresses thrombogenesis under arterial flow conditions and inhibited thrombosis in animals. These studies provide a link between matrix-dependent activation of metalloproteases and platelet-G protein signaling and identify MMP-1/PAR-1 as a new target for the treatment and prevention of arterial thrombosis and other thrombotic diseases.

Priority: US2009-168360P Applic. Date: 2009-04-10; US2009-168353P Applic. Date: 2009-04-10; WO2010US30783 Applic. Date: 2010-04-12

Inventor: KULIOPULOS ATHAN [US]; KOUKOS GEORGIOS [US]


Application No.: US20120122688A1  Published: 17/May/2012

Title: Agricultural pesticide compositions

Applicant/Assignee: RHODIA OPERATIONS

Application No.: 13/373330   Filing Date: 10/Nov/2011

Abstract:

A composition contains an agricultural pesticide and an incompletely hydrated water soluble polymer suspended in a liquid medium.

Priority: US2010-456776P Applic. Date: 2010-11-12

Inventor: WU DAN [US]; SHANMUGANANDAMURTHY KRISHNAMURTHY [US]; GOYAL RAJESH [US]; BRAMATI VALERIO [IT]


Application No.: US20120122996A1  Published: 17/May/2012

Title: AZEOTROPE-LIKE COMPOSITIONS COMPRISING 1-CHLORO-3,3,3-TRIFLUOROPROPENE

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 13/298483   Filing Date: 17/Nov/2011

Abstract:

An azeotrope-like mixture consisting essentially of chlorotrifluoropropene and at least one component selected from the group consisting of a C1-C3 alcohol, a C5-C6 hydrocarbon, a halogenated hydrocarbon, methylal, methyl acetone, water, nitromethane, and combinations thereof.

Priority: US2009-605609 Applic. Date: 2009-10-26; US2008-259694 Applic. Date: 2008-10-28; US2008-109007P Applic. Date: 2008-10-28

Inventor: BASU RAJAT [US]; BEMENT LESLIE [US]; COOK KANE [US]; HULSE RYAN [US]; KNOPECK GARY [US]; PHAM HANG T [US]; SINGH RAJIV R [US]; WILLIAMS DAVID J [US]


Application No.: US20120123182A1  Published: 17/May/2012

Title: DEVICES FOR THERMALLY INDUCED TRANSFORMATIONS CONTROLLED BY IRRADIATION OF FUNCTIONALIZED FULLERENES

Applicant/Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION. INC

Application No.: 13/106355   Filing Date: 12/May/2011

Abstract:

An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.

Priority: WO2009US63719 Applic. Date: 2009-11-09; US2008-113698P Applic. Date: 2008-11-12

Inventor: KRISHNA VIJAY [US]; ZAWOY KARL [US]; MOUDGIL BRIJ M [US]; KOOPMAN BENJAMIN L [US]; STEVENS NATHANAEL IAN [US]; POWERS KEVIN WILLIAM [US]


Application No.: US20120128731A1  Published: 24/May/2012

Title: BIOCOMPATIBLE CARRIER AND METHOD FOR FABRICATING THE SAME

Applicant/Assignee: NATIONAL SUN YAT-SEN UNIVERSITY

Application No.: 13/075103   Filing Date: 29/Mar/2011

Abstract:

The invention provides a biocompatible carrier and method for fabricating the same. The biocompatible carrier includes: a gel, and a plurality of metal nanoparticles, an organic compound or combinations thereof embedded in the gel, wherein the metal nanoparticles, the organic compound or combinations thereof are uniformly distributed in the gel.

Priority: TW20100139619 Applic. Date: 2010-11-18

Inventor: HSIEH SHU-CHEN [TW]


Application No.: US20120128760A1  Published: 24/May/2012

Title: LIPID COMPOSITIONS

Applicant/Assignee: ALNYLAM PHARMACEUTICALS, INC

Application No.: 13/318600   Filing Date: 05/May/2010

Abstract:

Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

Priority: US2010-299291P Applic. Date: 2010-01-28; WO2010US33777 Applic. Date: 2010-05-05; US2009-175770P Applic. Date: 2009-05-05

Inventor: MANOHARAN MUTHIAH [US]; RAJEEV KALLANTHOTTATHIL G [US]; JAYARAMAN MUTHUSAMY [US]; BUTLER DAVID [US]; JUNG MICHAEL E [US]


Application No.: US20120128767A1  Published: 24/May/2012

Title: THERAPEUTIC CALCIUM PHOSPHATE PARTICLES AND METHODS OF MAKING AND USING SAME

Applicant/Assignee:

Application No.: 12/434557   Filing Date: 01/May/2009

Abstract:

The present invention provides novel calcium phosphate nanoparticles suitable for efficient encapsulation of biologically active molecules. The invention further provides pharmaceutical compositions comprising these nanoparticles, as well as methods of making such nanoparticles and using them as carriers for therapeutic delivery of biologically active macromolecules.

Priority: US2008-049627P Applic. Date: 2008-05-01

Inventor: LEE WILLIAM W [US]; LU FENG [CN]


Application No.: US20120128774A1  Published: 24/May/2012

Title: MAXILLOFACIAL BONE AUGMENTATION USING RHPDGF-BB AND A BIOCOMPATIBLE MATRIX

Applicant/Assignee: BIOMIMETIC THERAPEUTICS, INC

Application No.: 13/344506   Filing Date: 05/Jan/2012

Abstract:

The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. In one embodiment, these materials include human recombinant platelet derived growth factor (rhPDGF-BB) and a biocompatible matrix. In another embodiment, these materials include rhPDGF-BB, a deproteinized bone block or calcium phosphate, and a bioresorbable membrane. The use of these materials in the present method is effective in regenerating maxillofacial bones and facilitating achievement of stable osseointegrated implants. The mandible and maxilla are preferred bones for augmentation, and enhancement of the alveolar ridge is a preferred embodiment of the present invention.

Priority: US2006-601376 Applic. Date: 2006-11-17; US2005-159533 Applic. Date: 2005-06-23; US2004-965319 Applic. Date: 2004-10-14; US2005-738076P Applic. Date: 2005-11-17

Inventor: LYNCH SAMUEL E [US]; NEVINS MYRON [US]; SIMION MASSIMO [IT]


Application No.: US20120128964A1  Published: 24/May/2012

Title: AZEOTROPE-LIKE COMPOSITIONS COMPRISING 1-CHLORO-3,3,3-TRIFLUOROPROPENE

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 13/296664   Filing Date: 15/Nov/2011

Abstract:

An azeotrope-like mixture consisting essentially of a binary azeotrope-like mixture consisting essentially of trans-1-chloro-3,3,3-trifluoropropene (trans-HFO-1233zd) and a second component selected from the group consisting of 2,3,3,3-tetrafluoropropene (HFO-1234yf) and trans-1,3,3,3-tetrafluoropropene (trans-HFO-1234ze), and combinations of these and various uses thereof.

Priority: US2010-415670P Applic. Date: 2010-11-19

Inventor: HULSE RYAN [US]; SINGH RAJIV R [US]; PHAM HANG T [US]


Application No.: US20120129951A1  Published: 24/May/2012

Title: Palatable Suspending Vehicle for Pharmaceutical Ingredients

Applicant/Assignee: GALLIPOT, INC

Application No.: 13/207849   Filing Date: 11/Aug/2011

Abstract:

The invention relates to a liquid vehicle that can be used to create suspensions and/or solutions of liquid or powdered medications. The vehicle is thixotropic and has improved stability and rheologic characteristics. Vehicles of the invention include an aqueous medium and a suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages. The polysaccharide can be a starch, modified starch, or glycogen. The aqueous medium and individual components of the vehicle provide a palatable and easily ingested drug preparation. The invention also provides a vehicle containing an aqueous medium, suspending agent comprising a polysaccharide having at least 50% glucose repeating saccharide units and at least 90% alpha linkages, buffer, and artificial sweetener, the combined suspending vehicle having a pH of about 3 to about 10 and an osmolality of 300 mOmsol or less.

Priority: US2004-601326P Applic. Date: 2004-08-13; US2005-203520 Applic. Date: 2005-08-12

Inventor: RADKE JOSHUA [US]; JONES MICHAEL [US]; ERICKSON MARTIN [US]


Application No.: US20120129952A1  Published: 24/May/2012

Title: NON-CAKING SALT COMPOSITION, PREPARATION PROCESS AND USE THEREOF

Applicant/Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V

Application No.: 13/322294   Filing Date: 27/May/2010

Abstract:

The present invention relates to a sodium chloride composition comprising an iron complex of tartaric acid wherein between 55 and 90% by weight of the tartaric acid is meso-tartaric acid. The present invention furthermore relates to a process to prepare such a sodium chloride composition and to the use of such a sodium chloride composition.

Priority: US2009-183254P Applic. Date: 2009-06-02; WO2010EP57286 Applic. Date: 2010-05-27; EP20090161722 Applic. Date: 2009-06-02

Inventor: BAKKENES HENDRIKUS WILHELMUS [NL]; BERGEVOET ROBERTO ALOYSIUS GERARDUS MARIA [NL]; MEIJER JOHANNES ALBERTUS MARIA [NL]; STEENSMA MARIA [NL]


Application No.: US20120129956A1  Published: 24/May/2012

Title: Moisturizing Compositions For Lip

Applicant/Assignee:

Application No.: 12/952624   Filing Date: 23/Nov/2010

Abstract:

A water in oil emulsion lip treatment composition comprising at least one non-polar silicone oil, at least one non-polar organic oil, at least one amphiphilic organic emollient oil, at least one water in oil surfactant

and at least one oil in water surfactant.

Priority:

Inventor: SUSAK MILANKA [US]; CASTRO JOHN R [US]; COHEN ISAAC DAVID [US]


Application No.: US20120130300A1  Published: 24/May/2012

Title: Therapeutic Methods Using Controlled Delivery Devices Having Zero Order Kinetics

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERITY OF TEXAS SYSTEM

Application No.: 13/383810   Filing Date: 14/Jul/2010

Abstract:

An injectable or implantable medical device having orifice(s) on the surface that release an active agent with zero-order release kinetics is described herein. The device is a hollow matrix of any size or shape, which can be made from both metal and non-metal surfaces. The device comprises of a reservoir capable of releasing at least one therapeutic, diagnostic, or prophylactic agent via the orifices to the desired anatomical site. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time. The composition provides zero-order kinetics, in part, because the diffusion rate of the drug from the device is slow which enables sink conditions. Hence, no back transfer or build up of drug occurs at anytime. Polymers are not required for controlled release.

Priority: US2009-225352P Applic. Date: 2009-07-14; US2009-225309P Applic. Date: 2009-07-14; WO2010US42029 Applic. Date: 2010-07-14

Inventor: STAVCHANSKY SALOMON S [US]; BOWMAN PHILLIP [US]; HO PAUL S [US]; RASTOGI ASHISH [US]; LUO ZHIQUAN [US]; WU ZHUOIJIE [US]


Application No.: US20120132204A1  Published: 31/May/2012

Title: UNIT DOSE DRY POWDER INHALER

Applicant/Assignee: INNOVATA BIOMED LIMITED

Application No.: 13/369458   Filing Date: 09/Feb/2012

Abstract:

An inhaler includes a first body member and a second body member fit closely together to form an inhaler body, and an outlet. The first body member has a medicament chamber containing a unit dose of powdered medicament. A seal such as a foil strip seals the medicament chamber and extends outwardly of the inhaler body. In use, one end of the seal can be grasped by a user and withdrawn, fully or partially, from the inhaler body, to release the powdered medicament from the medicament chamber. The second body member includes a medicament collection well in which the medicament is collected upon its release from the medicament chamber. The medicament collection well forms part of an airway connecting into the outlet. In use, air can be drawn by inhalation at the outlet to entrain the powder medicament in the collection well for inhalation by a user.

Priority: GB20050020794 Applic. Date: 2005-10-12; US2008-101721 Applic. Date: 2008-04-11; WO2006GB03803 Applic. Date: 2006-10-12

Inventor: LUCKING SAMUEL W [GB]; MARTYN GLEN P [GB]


Application No.: US20120134950A1  Published: 31/May/2012

Title: Adhesion-Promoting thin Film and Moisture Resistant Skin Barrier Compositions

Applicant/Assignee:

Application No.: 13/284053   Filing Date: 28/Oct/2011

Abstract:

Adhesion-promoting, thin film, moisture resistant skin barrier formulations are composed of a fugitive solvent mixture consisting of t-butanol and an alkane fraction composed of at least one alkane, where the t-butanol is in the range of 40-70% by weight of the solvent mixture, and a film-forming solute dissolved in the fugitive solvent mixture. The formulations may also include one or more optional ingredients such as antimicrobial and/or bioactive agents. When applied to the skin, the formulations improve the adhesion of various classes of medical adhesives used to attach a variety of medical devices to the skin and create a thin, flexible and elastic continuous barrier film on the skin to protect against body fluids and incontinence.

Priority: US2010-407533P Applic. Date: 2010-10-28

Inventor: BABB STEVEN J [US]; KAY DENNIS M [US]


Application No.: US20120134956A1  Published: 31/May/2012

Title: Colloidal metal compositions and methods

Applicant/Assignee: CYTIMMUNE SCIENCES, INC

Application No.: 13/282437   Filing Date: 26/Oct/2011

Abstract:

The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.

Priority: US2010-708326 Applic. Date: 2010-02-18; US2007-805383 Applic. Date: 2007-05-22; US2002-093578 Applic. Date: 2002-03-08; US2001-287363P Applic. Date: 2001-04-30

Inventor: TAMARKIN LAWRENCE [US]; PACIOTTI GIULIO F [US]


Application No.: US20120135052A1  Published: 31/May/2012

Title: METHOD FOR PREPARING AN ORGANIC-COMPATIBLE AND WATER-COMPATIBLE COMPOSITION OF METAL NANOCRYSTALS, AND RESULTING COMPOSITION

Applicant/Assignee:

Application No.: 13/376261   Filing Date: 04/Jun/2010

Abstract:

A method for preparing a composition of metal nanocrystals from at least one organometallic precursor in a solvent medium in the presence of a PEG ligand, including a carbon chain, at least one end of which is functionalized by a coordination grouping including at least one hetero atom, and having at least one [OCH2CH2]n grouping, n being an integer higher than 1, so as to be soluble both in the solvent medium and in water. The water-compatible and organic-compatible composition of metal nanocrystals thus obtained is also described.

Priority: FR20090002738 Applic. Date: 2009-06-05; WO2010FR51106 Applic. Date: 2010-06-04

Inventor: KAHN MYRTIL [FR]; GAUFFRE-GUIRARDEL FABIENNE [FR]; RUBIO-GARCIA JAVIER [ES]; MINGOTAUD CHRISTOPHE [FR]; CHAUDRET BRUNO [FR]; SALIBA SARMENIO [MT]


Application No.: US20120135075A1  Published: 31/May/2012

Title: DOSAGE FORM

Applicant/Assignee: EURO-CELTIQUE S.A

Application No.: 13/376113   Filing Date: 07/Jun/2010

Abstract:

The present invention provides a dosage form, particularly a tamper resistant dosage form, comprising: melt-extruded particulates comprising a drug

and a matrix

wherein said melt-extruded particulates are present as a discontinuous phase in said matrix.

Priority: GB20090009680 Applic. Date: 2009-06-05; WO2010GB50948 Applic. Date: 2010-06-07

Inventor: MOHAMMAD HASSAN [GB]


Application No.: US20120135079A1  Published: 31/May/2012

Title: Modified Release Tranexamic Acid Formulation

Applicant/Assignee: WATSON PHARMACEUTICALS, INC

Application No.: 12/956036   Filing Date: 30/Nov/2010

Abstract:

A modified release dosage form for the oral administration of tranexamic acid.

Priority:

Inventor: JOSHI MAYANK R [US]; FESHARAKI SHAHIN [US]


Application No.: US20120135086A1  Published: 31/May/2012

Title: METHOD OF TISSUE REPAIR USING A COMPOSITE MATERIAL

Applicant/Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, UT-BATTELLE, LLC

Application No.: 13/340114   Filing Date: 29/Dec/2011

Abstract:

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Priority: US2002-295461 Applic. Date: 2002-11-15

Inventor: HUTCHENS STACY A [US]; WOODWARD JONATHAN [GB]; EVANS BARBARA R [US]; O'NEILL HUGH M [US]


Application No.: US20120135969A1  Published: 31/May/2012

Title: NOVEL POWDERED CRYSTALLINE MEDICINES FOR INHALATION

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 13/131386   Filing Date: 23/Nov/2009

Abstract:

The invention relates to manufacturing processes for preparing inhalable powders, and to the stable crystalline inhalable powders prepared by this process. Similarly, the invention relates to the use of these inhalable powders for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Priority: EP20080170072 Applic. Date: 2008-11-27; WO2009EP65621 Applic. Date: 2009-11-23

Inventor: WEILER CLAUDIUS [DE]; EGEN MARC [DE]


Application No.: US20120135991A1  Published: 31/May/2012

Title: ORALLY RAPIDLY DISINTEGRATING TABLET THAT CONTAINS TWO OR MORE TYPES OF PARTICLES

Applicant/Assignee: DAINIPPON SUMITOMO PHARMA CO., LTD

Application No.: 13/389280   Filing Date: 11/Aug/2010

Abstract:

The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition)

a small size

no unpleasant taste

a pleasant feeling in a mouth after administration

and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.

Priority: JP20090186643 Applic. Date: 2009-08-11; WO2010JP63599 Applic. Date: 2010-08-11

Inventor: FUJIWARA KEIICHI [JP]


Application No.: US20120136021A1  Published: 31/May/2012

Title: OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM

Applicant/Assignee: GRUNENTHAL GMBH

Application No.: 13/343846   Filing Date: 05/Jan/2012

Abstract:

A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.

Priority: EP20090009480 Applic. Date: 2009-07-22; WO2010EP04461 Applic. Date: 2010-07-21

Inventor: BARNSCHEID LUTZ [DE]; GALIA ERIC [DE]; SCHWIER SEBASTIAN [DE]; BERTRAM ULRIKE [DE]; GEISSLER ANJA [DE]; GRIESSMANN KORNELIA [DE]; BARTHOLOMAEUS JOHANNES [DE]


Application No.: US20120136051A1  Published: 31/May/2012

Title: RHEOLOGY MODIFIED LOW FOAMING LIQUID ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee: ECOLAB USA INC

Application No.: 13/112624   Filing Date: 20/May/2011

Abstract:

The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.

Priority: US2010-346804P Applic. Date: 2010-05-20

Inventor: LI JUNZHONG [US]; LANGE STEVEN J [US]; STAUB RICHARD K [US]; MCSHERRY DAVID D [US]


Application No.: US20120141585A1  Published: 07/Jun/2012

Title: IMMUNOMODULATORY COMPOSITIONS COMPRISING A POLYMER MATRIX AND AN OIL PHASE

Applicant/Assignee:

Application No.: 13/390085   Filing Date: 12/Aug/2010

Abstract:

A pharmaceutical composition comprising a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising at least one immunomodulator selected from an adjuvant, an antigen or a combination thereof. A method of manufacturing shaped compositions comprises mixing an aqueous solution of a water-soluble polymer with an oil-based liquid to form a water-in-oil emulsion, at least one of the aqueous solution and the oil-based liquid comprising an antigen or an adjuvant or a combination thereof, and then causing or allowing the resultant suspension to solidify into one or more beads or other shaped elements

Priority: IE20090000618 Applic. Date: 2009-08-12; US2009-233170P Applic. Date: 2009-08-12; WO2010EP61791 Applic. Date: 2010-08-12

Inventor: COULTER IVAN [IE]; MCDONALD BERNARD FRANCIS [IE]; AVERSA VINCENZO [IE]


Application No.: US20120141587A1  Published: 07/Jun/2012

Title: COMPOSITIONS AND METHODS FOR TREATMENT OR PREVENTION OF POST-OPERATIVE ORGAN OR TISSUE INFLAMMATION

Applicant/Assignee:

Application No.: 13/382771   Filing Date: 25/Aug/2010

Abstract:

Compositions, methods and kits for treatment or prevention of post operative organ or tissue inflammation are provided. The compositions contain an effective amount for local delivery, of an anti-inflammatory agent, alone or in combination with other pharmacologic agents, embedded within a polymeric matrix or gel. The polymeric matrix or gel may be a formed from natural or synthetic precursor components. The compositions are applied locally to an organ or tissue for the treatment or prevention of post inflammation resulting from surgical intervention.

Priority: US2009-236726P Applic. Date: 2009-08-25; WO2010US46621 Applic. Date: 2010-08-25

Inventor: YOO DALE [US]; WHALEN SEAN PARICK [US]; LANGBERG JONATHAN [US]


Application No.: US20120142533A1  Published: 07/Jun/2012

Title: REDUCED VAPORIZATION COMPOSITIONS AND METHODS

Applicant/Assignee: ACCUFORM TECHNOLOGIES, LLC

Application No.: 13/378624   Filing Date: 15/Jun/2010

Abstract:

The present invention provides compositions, systems, and methods employing materials to reduce or eliminate vapor transfer of an active substance from a target surface to a non-target surface. In certain embodiments, a material is mixed with a liquid, gas, and/or solid comprising an active substance to form a mixture such that the mixture has a lower vapor pressure than the liquid, gas, and/or solid. In some embodiments, the active substance is a herbicide and the target surface is an agricultural field or crop.

Priority: US2009-187054P Applic. Date: 2009-06-15; WO2010US38646 Applic. Date: 2010-06-15

Inventor: RICHARD THOMAS J [US]; ROWLEY KEITH R [US]


Application No.: US20120142535A1  Published: 07/Jun/2012

Title: HYDROLYSIS RESISTANT ORGANOMODIFIED TRISILOXANE IONIC SURFACTANTS

Applicant/Assignee:

Application No.: 13/251667   Filing Date: 03/Oct/2011

Abstract:

The present invention provides for a composition comprising a siloxane having the formula: M1DM2 wherein M1=(R1)(R2)(R3)SiO1/2

M2=(R4)(R5)(R6)SiO1/2 and D=(R7)(Z)SiO2/2 where R1, R2, R3, R4, R5, R6 and R7 are each independently selected from the group consisting of 1 to 4 carbon monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 4 to 9 carbons containing an aryl group

Z is a pendant hydrophilic ionic group selected from the group consisting of R8-RA, R9-RC, and R10-RZ

RA being an anionic substituent, RC a cationic substituent or RZ a zwitterionic substituent on the D group wherein said siloxane has an enhanced resistance to hydrolysis at a pH below 6 or a pH above 7.5.

Priority: US2007-964186 Applic. Date: 2007-12-26

Inventor: LEATHERMAN MARK D [US]; POLICELLO GEORGE A [US]; PENG WENQING N [CN]; ZHENG LIPING [CN]; WAGNER ROLAND [DE]; RAJARAMAN SURESH K [US]; XIA ZIJUN [CN]


Application No.: US20120142737A1  Published: 07/Jun/2012

Title: PHARMACEUTICAL COMPOSITIONS OF A NON-ENTERIC COATED PROTON PUMP INHIBITOR WITH A CARBONATE SALT AND BICARBONATE SALT COMBINATION

Applicant/Assignee:

Application No.: 13/052834   Filing Date: 21/Mar/2011

Abstract:

A method for treating gastric acid disorders with a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal

and a pharmaceutical composition of a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal are disclosed. A presently preferred proton pump inhibitor is lansoprazole, a presently preferred bicarbonate salt is sodium bicarbonate, and a presently preferred carbonate salt is sodium carbonate. The composition is a fast-acting formulation which reduces the undesirable belching associated with proton pump inhibitor formulations that contain high doses of sodium bicarbonate.

Priority: US2009-464847 Applic. Date: 2009-05-12; US2001-036129 Applic. Date: 2001-12-26; US2000-258498P Applic. Date: 2000-12-28

Inventor: TANEJA RAJNEESH [US]; GUPTA PRAMOD [US]


Application No.: US20120145590A1  Published: 14/Jun/2012

Title: Solvent Composition For Conversion Of Makeup Cosmetic

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 13/257336   Filing Date: 18/Mar/2010

Abstract:

Problem: To provide a technique of simply and easily convert a powder makeup cosmetic such as powdery foundation or the like into a pickering-emulsificated liquid makeup cosmetic such as liquid foundation or the like. Means for Resolution: A solvent composition for use as a dispersion medium for converting a powder makeup cosmetic into a pickering-emulsificated liquid makeup cosmetic, which comprises (a) from 0.1 to 65% by mass of an aqueous component, and (b) from 35 to 99.9% by mass of one or more oily components selected from hydrocarbon oils and silicone oils.

Priority: JP20090069088 Applic. Date: 2009-03-19; WO2010JP54643 Applic. Date: 2010-03-18

Inventor: YAMAGUCHI KANAKO [JP]; YOKOO MIHOSHI [JP]


Application No.: US20120148508A1  Published: 14/Jun/2012

Title: Coloured fragrancing composition with no alkyl diphenylacrylate that contains a derivative of benzylidene camphor containing a sulphonic function or a benzotriazole silicone

Applicant/Assignee: L'OREAL

Application No.: 12/949406   Filing Date: 18/Nov/2010

Abstract:

The invention relates to a coloured fragrancing composition comprising, in a cosmetically acceptable medium: a) at least 2% by weight of a fragrancing substance relative to the total weight of the composition

b) at least one derivative of: benzylidene camphor containing a sulphonic function or a benzotriazole silicone of particular formula (1) that will be defined below in detail

c) at least one dye that is soluble in said medium

said composition not containing an alkyl [beta],[beta]'-diphenylacrylate compound or an alkyl [alpha]-cyano-[beta],[beta]'-diphenylacrylate compound. The invention also relates to a cosmetic method for fragrancing human keratin substances and in particular the skin, lips and integuments, comprising the application to the keratin substances of the composition defined previously.

Priority: FR20090058181 Applic. Date: 2009-11-19; FR20090058183 Applic. Date: 2009-11-19; US2009-265593P Applic. Date: 2009-12-01; US2009-265583P Applic. Date: 2009-12-01

Inventor: THFOIN WILLY [FR]; GRIMAL BORIS [FR]


Application No.: US20120148651A1  Published: 14/Jun/2012

Title: Articles Having Antimicrobial Properties And Methods of Manufacturing the Same

Applicant/Assignee: MEDLINE INDUSTRIES INC

Application No.: 12/965658   Filing Date: 10/Dec/2010

Abstract:

According to one embodiment, a coagulant comprising calcium nitrate and an antimicrobial agent is disclosed. The coagulant may be used in the molding process to releasably bond the substrate material to the mold and to bond to the antimicrobial to the substrate material.

Priority:

Inventor: AMDUR SAMUEL T [US]; YAO MIN [US]


Application No.: US20120148674A1  Published: 14/Jun/2012

Title: SELF-ASSEMBLING HYDROGELS BASED ON DICEPHALIC PEPTIDE AMPHIPHILES

Applicant/Assignee: ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC

Application No.: 12/962775   Filing Date: 08/Dec/2010

Abstract:

We have disclosed dicephalic amphiphiles having peptide sequences as the head groups. We have also disclosed self-assembly hydrogels prepared from the dicephalic peptide amphiphiles. These hydrogels are useful for the encapsulation and delivery of bioactives to a patient.

Priority:

Inventor: DONNERS JACKIE J [US]; NATHAN ARUNA [US]


Application No.: US20120152262A1  Published: 21/Jun/2012

Title: APPARATUS AND METHOD FOR MOVING AND ACTIVATING AN ACTIVE AGENT

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 13/392536   Filing Date: 06/Sep/2010

Abstract:

The present invention relates to an apparatus (100) for moving a target element (60, 70), which comprises a magnetic material (62, 72) and an active agent (61, 71), through an object, placing said target element (60, 70) at a predetermined position within the object and activating the active agent (61, 71), which apparatus (100) comprises:-selection means comprising a selection field signal generator unit (110) and selection field elements (116), in particular selection field magnets or coils, for generating a magnetic selection field (50) having a pattern in space of its magnetic field strength such that a first sub-zone (52) having a low magnetic field strength and a second sub-zone (54) having a higher magnetic field strength are formed in a field of view (28),-drive means comprising a drive field signal generator unit (130) and drive field coils (136a, 136b, 136c) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic material (62, 72) changes locally, and-control means (150) for controlling said signal generator units (110, 130)

to generate and provide control currents to the respective field coils to generate appropriate magnetic fields for moving the target element (60, 70) through the object in a direction instructed by movement commands, for placing the target element (60, 70) at the desired position within the object and for activating the active agent (61, 71) when the target element (60, 70) has reached said desired position.

Priority: EP20090170211 Applic. Date: 2009-09-14; WO2010IB53990 Applic. Date: 2010-09-06

Inventor: GLEICH BERNHARD [DE]


Application No.: US20120156261A1  Published: 21/Jun/2012

Title: DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET

Applicant/Assignee:

Application No.: 13/389880   Filing Date: 11/Aug/2010

Abstract:

There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.

Priority: WO2010JP63601 Applic. Date: 2010-08-11; JP20090186646 Applic. Date: 2009-08-11

Inventor: FUJIWARA KEIICHI [JP]; FUKAMI TADASHI [JP]; KOIZUMI HARUKA [JP]


Application No.: US20120156289A1  Published: 21/Jun/2012

Title: Biodegradable Osmotic Pump Implant For Drug Delivery

Applicant/Assignee: CONFLUENT SURGICAL, INC

Application No.: 12/974394   Filing Date: 21/Dec/2010

Abstract:

The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.

Priority:

Inventor: BLASKOVICH PHILLIP [US]; OHRI RACHIT [US]; BENNETT STEVEN [US]


Application No.: US20120156297A1  Published: 21/Jun/2012

Title: COMPOSITIONS COMPRISING LILIUM CANDIDUM EXTRACTS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/971342   Filing Date: 17/Dec/2010

Abstract:

Provided are compositions comprising certain extracts of Lilium Candidum and a carrier. Also provided are methods of lightening the skin comprising the step of applying to skin in need of skin lightening treatment one or more certain extracts of Lilium Candidum.

Priority:

Inventor: LOY CHONG JIN [SG]; MAHMOOD KHALID [US]; SALIOU CLAUDE [US]


Application No.: US20120156298A1  Published: 21/Jun/2012

Title: COMPOSITIONS COMPRISING LILIUM SIBERIA EXTRACTS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/971512   Filing Date: 17/Dec/2010

Abstract:

Provided are compositions comprising an extract of Lilium siberia and a carrier. Also provided are methods of lightening the skin comprising the step of applying to skin in need of skin lightening treatment an extract of Lilium siberia.

Priority:

Inventor: LOY CHONG JIN [SG]; MAHMOOD KHALID [US]; SALIOU CLAUDE [US]; YU LIJUN [SG]


Application No.: US20120156299A1  Published: 21/Jun/2012

Title: COMPOSITIONS COMPRISING LILIUM MARTAGON EXTRACTS AND USES THEREOF

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 12/971518   Filing Date: 17/Dec/2010

Abstract:

Provided are compositions comprising an extract of Lilium martagon and a carrier. Also provided are methods of lightening the skin comprising the step of applying to skin in need of skin lightening treatment an extract of Lilium martagon.

Priority:

Inventor: MAHMOOD KHALID [US]


Application No.: US20120157416A1  Published: 21/Jun/2012

Title: XYLITOL CONTAINING COMESTIBLE PRODUCT

Applicant/Assignee: HERSHEY FOODS CORPORATION

Application No.: 13/392689   Filing Date: 30/Aug/2010

Abstract:

The present invention relates to a process for preparing a comestible product comprising xylitol said method comprising: (a) subjecting a composition comprising xylitol in an amount ranging from about 60% to about 100% by weight to extrusion treatment inside an extrusion apparatus under conditions sufficient to form and maintain the xylitol in a slurry and (b) then shaping the extruded slurry and cooling the product to form a solid. The present invention additionally is directed to a product produced therefrom.

Priority: US2009-238017P Applic. Date: 2009-08-28; WO2010US47071 Applic. Date: 2010-08-30

Inventor: KUMIEGA STEVEN M [US]; CARROLL THOMAS J [US]; BOLDT ASHLEY L [US]; GIBSON PAULA M [US]; HUZINEC ROBERT J [US]; BROWN BURTON DOUGLAS [US]; STUMPF DAVID M [US]


Application No.: US20120157939A1  Published: 21/Jun/2012

Title: COMPOSITIONS COMPRISING LILIUM SIBERIA EXTRACTS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/971351   Filing Date: 17/Dec/2010

Abstract:

Provided are compositions comprising an extract of Lilium siberia and a carrier. Also provided are methods of lightening the skin comprising the step of applying to skin in need of skin lightening treatment an extract of Lilium siberia.

Priority:

Inventor: LOY CHONG JIN [SG]; MAHMOOD KHALID [US]; SALIOU CLAUDE [US]; YU LIJUN [SG]


Application No.: US20120164069A1  Published: 28/Jun/2012

Title: Compositions and methods for surface abrasion with frozen particles

Applicant/Assignee: SEARETE LLC

Application No.: 12/290659   Filing Date: 31/Oct/2008

Abstract:

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Priority:

Inventor: BOYDEN EDWARD S [US]; COOK DANIEL B [US]; HYDE RODERICK A [US]; LEUTHARDT ERIC C [US]; MYHRVOLD NATHAN P [US]; SWEENEY ELIZABETH A [US]; WOOD JR LOWELL L [US]


Application No.: US20120164207A1  Published: 28/Jun/2012

Title: Degradable networks for sustained release and controlled release depot drug delivery applications

Applicant/Assignee:

Application No.: 12/930044   Filing Date: 23/Dec/2010

Abstract:

Provided herein is a controlled release and/or sustained release depot drug delivery system, comprising, a biodegradable polymer coating and an API coated with the biodegradable polymer coating, wherein a quantity of API coated with biodegradable polymer is effective to be released from the biodegradable polymer coating over a prolonged period of time.

Priority:

Inventor: GOOBERMAN LANCE L [US]


Application No.: US20120164224A1  Published: 28/Jun/2012

Title: Hemostatic Preparation Containing an Extract of Golden Moss

Applicant/Assignee:

Application No.: 12/975589   Filing Date: 22/Dec/2010

Abstract:

The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based "Traditional Chinese Medicinal" product and devices incorporating such agents for the delivery thereof to bleeding wounds.

Priority:

Inventor: WANG YI-LAN [US]; MING XINTIAN [US]


Application No.: US20120164225A1  Published: 28/Jun/2012

Title: BONE GRAFT MATERIALS AND METHODS

Applicant/Assignee:

Application No.: 12/977191   Filing Date: 23/Dec/2010

Abstract:

Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 [mu]m to about 425 [mu]m in size.

Priority:

Inventor: COOK RUSSELL L [US]; ANTONE DURAID S [US]


Application No.: US20120165413A1  Published: 28/Jun/2012

Title: DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET

Applicant/Assignee:

Application No.: 13/389874   Filing Date: 11/Aug/2010

Abstract:

Disclosed is an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity. The orally rapidly disintegrating tablet, which has a good texture and taste, an appropriate hardness, and good disintegrating properties, can be produced by using a composition, which is prepared by dispersing, by spray-drying, an inorganic excipient and starch(es) in complex particles composed of mannitol and xylitol, in an orally rapidly disintegrating tablet.

Priority: JP20090186648 Applic. Date: 2009-08-11; WO2010JP63602 Applic. Date: 2010-08-11

Inventor: FUJIWARA KEIICHI [JP]; FUKAMI TADASHI [JP]; KOIZUMI HARUKA [JP]


Application No.: US20120171137A1  Published: 05/Jul/2012

Title: COMFORTABLE, LONG-WEARING, TRANSFER-RESISTANT COLORED COSMETIC COMPOSITIONS HAVING A NON-TACKY FEEL

Applicant/Assignee: L'OREAL S.A

Application No.: 12/981839   Filing Date: 30/Dec/2010

Abstract:

The present invention is directed to an anhydrous composition which is long wearing and transfer resistant, while at the same time providing superior comfort, non-tacky feel and cushioning, the composition containing:(a) at least one silsesquioxane resin

(b) at least one polypropylsilsesquioxane wax substituted with alkyl units having at least 30 carbons

(c) at least one siloxysilicate resin

(d) at least one volatile solvent

(e) optionally, at least one non-volatile solvent

and (f) at least one colorant.

Priority:

Inventor: BRADSAW KIMBERLY [US]; BUI HY SI [US]


Application No.: US20120171138A1  Published: 05/Jul/2012

Title: COMFORTABLE, LONG-WEARING, TRANSFER-RESISTANT COLORED COSMETIC COMPOSITIONS HAVING HIGH GLOSS AND A NON-TACKY FEEL

Applicant/Assignee: L'OREAL S.A

Application No.: 12/981882   Filing Date: 30/Dec/2010

Abstract:

The present invention is directed to an anhydrous glossy composition which is long wearing and transfer resistant, while at the same time providing superior comfort, non-tacky feel and cushioning, the composition containing (a) at least one siloxysilicate resin

(b) at least one polyorganosiloxane-containing polymer

(c) at least one volatile solvent

(d) at least one non-volatile solvent having more than one phenyl group

and (e) optionally, at least one colorant

and wherein the ratio by weight of (b) to (a) is greater than or equal to 1.

Priority:

Inventor: BRADSHAW KIMBERLY [US]; BUI HY SI [US]


Application No.: US20120171139A1  Published: 05/Jul/2012

Title: COMFORTABLE, LONG-WEARING, TRANSFER-RESISTANT COLORED COSMETIC COMPOSITIONS

Applicant/Assignee: L'OREAL S.A

Application No.: 12/982061   Filing Date: 30/Dec/2010

Abstract:

The present invention is directed to an anhydrous composition which is long wearing and transfer resistant, while at the same time providing superior comfort, feel and cushioning, the composition containing: (a) at least one polypropylsilsesquioxane wax substituted with alkyl units having at least 30 carbons

(b) at least one siloxysilicate resin

(c) at least one polyorganosiloxane-containing polymer

(d) at least one volatile solvent

(e) optionally, at least one non-volatile solvent

and (f) at least one colorant.

Priority:

Inventor: BRADSHAW KIMBERLY [US]; BUI HY SI [US]


Application No.: US20120171141A1  Published: 05/Jul/2012

Title: EMULSIONS CONTAINING A MICRONIZED WAX

Applicant/Assignee: L'OREAL S.A

Application No.: 13/341514   Filing Date: 30/Dec/2011

Abstract:

The invention relates to a composition comprising at least one micronized wax which, if desired, can be processed at room temperature.

Priority: US201061428537P Applic. Date: 2010-12-30

Inventor: BUI HY SI [US]; TONG ANITA CHON [US]; HALPERN SUSAN [US]; KANJI MOHAMED [US]


Application No.: US20120171264A1  Published: 05/Jul/2012

Title: Granulated Dry Cleanser For The Care Of Keratinous Substrates

Applicant/Assignee:

Application No.: 13/390130   Filing Date: 03/Aug/2010

Abstract:

Described herein is a granulated dry composition comprising at least one non-elastomeric polyorganosiloxane, agglomerated onto solid carrier particles. The granulated dry compositions can be used as a dry cleanser for keratinous substrates with high speed of absorption of body fluids together with improved sensory feel and release of care agents.

Priority: US2009-233572P Applic. Date: 2009-08-13; WO2010US44182 Applic. Date: 2010-08-03

Inventor: BERNET CLAIRE-SOPHIE [BE]; CREUTZ SERGE [BE]; POSTIAUX STEPHANIE [BE]; VANDEMEULEBROUCKE FLORE MARTINE JEANNE [BE]


Application No.: US20120172451A1  Published: 05/Jul/2012

Title: CLEANING LIQUID

Applicant/Assignee:

Application No.: 13/329039   Filing Date: 16/Dec/2011

Abstract:

The present invention relates to a cleaning fluid, in particular a cleaning fluid for cleaning surfaces.

Priority: GB20100021452 Applic. Date: 2010-12-17

Inventor: MATHARU NAVJEET KAUR [GB]


Application No.: US20120172796A1  Published: 05/Jul/2012

Title: COMPOSITION FOR INTRAVASCULAR DELIVERY OF THERAPEUTIC COMPOSITION

Applicant/Assignee:

Application No.: 13/339908   Filing Date: 29/Dec/2011

Abstract:

The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.

Priority: US201061428397P Applic. Date: 2010-12-30

Inventor: CHAPPA RALPH A [US]


Application No.: US20120177702A1  Published: 12/Jul/2012

Title: Solid Forms for Tissue Repair

Applicant/Assignee: CARTIHEAL (2009) LTD

Application No.: 13/378474   Filing Date: 23/May/2010

Abstract:

This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.

Priority: US2009-187081P Applic. Date: 2009-06-15; US2009-252800P Applic. Date: 2009-10-19; WO2010IL00410 Applic. Date: 2010-05-23

Inventor: ALTSCHULER NIR [IL]; VAGO RAZI [IL]


Application No.: US20120177709A1  Published: 12/Jul/2012

Title: LOW PH STRUCTURED SURFACTANT COMPOSITION

Applicant/Assignee: RHODIA OPERATIONS

Application No.: 13/422667   Filing Date: 16/Mar/2012

Abstract:

An aqueous, low pH structured surfactant composition, contains, based on 100 parts by weight of the composition, from about 3 parts by weight to about 40 parts by weight of one or more anionic surfactants selected from anionic phosphate ester surfactants, anionic sulfonate surfactants, and anionic carboxylate surfactants, wherein the composition exhibits a pH of less than about 5, exhibits shear-thinning viscosity, and is capable of suspending water insoluble or partially water soluble components.

Priority: US2005-205877 Applic. Date: 2005-08-17; US2004-602156P Applic. Date: 2004-08-17

Inventor: FRANTZ SEREN [US]; WARBUTON STEWART ALEXANDER [US]


Application No.: US20120178684A1  Published: 12/Jul/2012

Title: Surgical Calcium Phosphate Citrate-Containing Cement and Method of Manufacturing the Same

Applicant/Assignee: MAXIGEN BIOTECH INC

Application No.: 13/004560   Filing Date: 11/Jan/2011

Abstract:

The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof

a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof

and water

wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.

Priority:

Inventor: LIU SUNG-TSUEN [TW]; CHEN SUNG-CHING [TW]; LAI HUI-CHUN [TW]; CHIEN KEHSIN [TW]


Application No.: US20120178823A1  Published: 12/Jul/2012

Title: GEL-LIKE COMPOSITION

Applicant/Assignee:

Application No.: 13/497444   Filing Date: 16/Sep/2010

Abstract:

Provided is a gel-like composition which has such satisfactory safety, storage stability, and versatility as to be widely used typically as cosmetics and pharmaceutical vehicles. The gel-like composition contains a polyglycerol monoalkyl ether represented by following Formula (1): RO-(C3H6O2)n-H (1) wherein RO represents an alkoxy group having 12 to 22 carbon atoms, and "n" denotes a degree of glycerol polymerization and is 4 to 100 in a content of from 0.1 to 20 percent by weight

an aqueous component in a content of 0.65 to 1.5 times by weight relative to the content of the polyglycerol alkyl ether

and an oily component in a content of from 50 to 99.835 percent by weight.

Priority: JP20090226037 Applic. Date: 2009-09-30; WO2010JP66063 Applic. Date: 2010-09-16

Inventor: SAKANISHI YUICHI [JP]


Application No.: US20120178828A1  Published: 12/Jul/2012

Title: PROCESS FOR THE PREPARATION OF A FLAVORING CONCENTRATE, AND A FLAVORING CONCENTRATE

Applicant/Assignee: SYMRISE AG

Application No.: 13/420821   Filing Date: 15/Mar/2012

Abstract:

The present invention relates to processes for the preparation of a flavoring concentrate, to a flavoring concentrate which can be prepared by a process according to the invention, to products comprising one or more flavoring concentrates according to the invention, and to processes for the concentration of flavoring and/or aromatic substances.

Priority: US2008-335859 Applic. Date: 2008-12-16; US2007-014146P Applic. Date: 2007-12-17

Inventor: REISS INGO [DE]; ERFURT HARRY [DE]; OTT FRANK [DE]; KINDEL GUENTER [DE]; GABRIEL BERND [DE]


Application No.: US20120181448A1  Published: 19/Jul/2012

Title: PRODUCT MARKING

Applicant/Assignee: RHINO RESEARCH EUROPE B.V

Application No.: 13/320534   Filing Date: 12/May/2010

Abstract:

The present invention relates to a method for the authentication of a product, comprising providing said product with at least one marker, wherein said marker is a phosphorescent marker selected from a set of m phosphorescent markers each having a different emission spectrum, wherein m is an integer equal or greater than 3, and wherein said marker is provided at an amount that results in a phosphor-specific emission below background radiation emitted from said product.

Priority: EP20090160309 Applic. Date: 2009-05-14; WO2010NL50274 Applic. Date: 2010-05-12

Inventor: VAN ASBROUCK JOHAN GASTON MARIE [TH]


Application No.: US20120183490A1  Published: 19/Jul/2012

Title: NOVEL 1,3-OXATHIANE COMPOUNDS AND THEIR USE IN FLAVOR AND FRAGRANCE COMPOSITIONS

Applicant/Assignee:

Application No.: 13/430772   Filing Date: 27/Mar/2012

Abstract:

The present invention relates to novel 1,3-oxathiane compounds represented by Formula I: wherein R is selected from the group consisting of ethyl, butyl, propyl, and (methylthio)ethyl, and their uses to enhance a flavor or fragrance composition.

Priority: US2008-261538 Applic. Date: 2008-10-30

Inventor: CHEN ZHEN [US]; DEWIS MARK L [US]; MERRITT DEBRA [US]


Application No.: US20120183584A1  Published: 19/Jul/2012

Title: METHOD FOR PREPARING A STABLE OIL-IN-WATER EMULSION

Applicant/Assignee: SAS GENIALIS

Application No.: 13/379652   Filing Date: 22/Jun/2010

Abstract:

The invention relates to a method for preparing a stable oil-in-water emulsion without adding an emulsifier. According to the method, a mixture of a lipid phase and an aqueous phase is subjected to vibrating energy, in a sealed container, by applying a transducer operating at a frequency of more than 900 kHz.

Priority: FR20090054323 Applic. Date: 2009-06-24; WO2010EP58848 Applic. Date: 2010-06-22

Inventor: DESJARDINS-LAVISSE ISABELLE [FR]; DESOBRY STEPHANE [FR]


Application No.: US20120183609A1  Published: 19/Jul/2012

Title: MODULAR SYSTEMS FOR THE CONTROLLED RELEASE OF A SUBSTANCE WITH SPACE AND TIME CONTROL

Applicant/Assignee: UNIVERSITA' DEGLI STUDI DI PARMA

Application No.: 13/410550   Filing Date: 02/Mar/2012

Abstract:

An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.

Priority: IT2001MI02481 Applic. Date: 2001-11-23; US2004-496327 Applic. Date: 2004-05-21; WO2002EP12988 Applic. Date: 2002-11-20

Inventor: COLOMBO PAOLO [IT]; BETTINI RUGGERO [IT]; SANTI PATRIZIA [IT]; CATELLANI PIER LUIGI [IT]


Application No.: US20120183616A1  Published: 19/Jul/2012

Title: LONG ACTING INSULIN COMPOSITION

Applicant/Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH

Application No.: 13/387959   Filing Date: 30/Jul/2010

Abstract:

The present invention relates to a pharmaceutical composition comprising an insulin compound in a concentration that is sufficient to maintain a therapeutically effective level of the insulin compound in blood plasma for at least 3 days characterized by having a pharmacokinetic profile in vivo with substantially no burst of the insulin compound. The present invention further relates to the use of an insulin compound for preparing said pharmaceutical composition as well as a kit of parts comprising said pharmaceutical composition.

Priority: EP20090167017 Applic. Date: 2009-07-31; EP20090179337 Applic. Date: 2009-12-15; EP20090179827 Applic. Date: 2009-12-18; WO2010EP61160 Applic. Date: 2010-07-30

Inventor: SPROGOE KENNETT [DK]; CLEEMANN FELIX [DE]; HERSEL ULRICH [DE]; KADEN-VAGT SILVIA [DE]; LESSMANN TORBEN [DE]; RAU HARALD [DE]; WEGGE THOMAS [DE]


Application No.: US20120183617A1  Published: 19/Jul/2012

Title: COMPOSITION AND METHOD FOR TREATMENT OF DIABETES

Applicant/Assignee: BIOKIER, INC

Application No.: 13/497114   Filing Date: 22/Sep/2010

Abstract:

The present invention relates to a method of treating an incretin related disease such as diabetes, obesity and the like by delivery of butyric acid, bile acid, long chain fatty acid or glutamine to the colon by bypassing the upper digestive tract. The composition is combined either by the same or different route of administration with a monoamine reuptake inhibitor such as buproprion.

Priority: US2009-245036P Applic. Date: 2009-09-23; WO2010US49843 Applic. Date: 2010-09-22

Inventor: SZEWCZYK JERZY RYSZARD [US]


Application No.: US20120183618A1  Published: 19/Jul/2012

Title: MODULAR SYSTEMS FOR THE CONTROLLED RELEASE OF A SUBSTANCE WITH SPACE AND TIME CONTROL

Applicant/Assignee: UNIVERSITA' DEGLI STUDI DI PARMA

Application No.: 13/410560   Filing Date: 02/Mar/2012

Abstract:

An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.

Priority: IT2001MI02481 Applic. Date: 2001-11-23; US2004-496327 Applic. Date: 2004-05-21; WO2002EP12988 Applic. Date: 2002-11-20

Inventor: COLOMBO PAOLO [IT]; BETTINI RUGGERO [IT]; SANTI PATRIZIA [IT]; CATELLANI PIER LUIGI [IT]


Application No.: US20120184443A1  Published: 19/Jul/2012

Title: Alkoxylated Glycerol Acetals And Their Derivatives

Applicant/Assignee: COGNIS IP MANAGEMENT GMBH

Application No.: 13/499324   Filing Date: 23/Sep/2010

Abstract:

Described are alkoxylated glycerol acetals according to Formulas (Ia) and (Ib) wherein R1 represents a linear or branched, saturated or unsaturated and optionally substituted hydrocarbyl residue comprising 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, a benzyl or furfuryl radical, R2 is selected from hydrogen, an alkyl, alkenyl or hydroxyalkyl group having 6 to 22 carbon atoms or an acyl group having 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, AO represents an ethylene oxide, a propylene oxide, a butylene oxide unit, or their mixtures, and n is an integer of about 1 to about 100.

Priority: EP20090012496 Applic. Date: 2009-10-02; WO2010EP05825 Applic. Date: 2010-09-23

Inventor: FLEUTE-SCHLACHTER INGO [DE]; HELDT SANDRA [DE]; KEMPERS PETER [DE]; SCHOERKEN ULRICH [DE]; PAETZOLD ECKHARD [DE]; KRAGL UDO [DE]


Application No.: US20120184627A1  Published: 19/Jul/2012

Title: PHARMACEUTICAL COMPOSITION

Applicant/Assignee:

Application No.: 13/498528   Filing Date: 24/Sep/2010

Abstract:

The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.

Priority: IES20090746 Applic. Date: 2009-09-28; WO2010EP64182 Applic. Date: 2010-09-24

Inventor: CROWLEY MICHAEL [US]; GAGE AMANDA [US]; MAEGLI JACK [US]; O'REILLY TIMOTHY [US]


Application No.: US20120189669A1  Published: 26/Jul/2012

Title: Solid Forms for Tissue Repair

Applicant/Assignee: CARTIHEAL (2009) LTD

Application No.: 13/378458   Filing Date: 23/May/2010

Abstract:

This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.

Priority: WO2010IL00409 Applic. Date: 2010-05-23; US2009-187081P Applic. Date: 2009-06-15; US2009-252800P Applic. Date: 2009-10-19

Inventor: ALTSCHULER NIR [IL]; VAGO RAZI [IL]


Application No.: US20120189691A1  Published: 26/Jul/2012

Title: DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 13/439330   Filing Date: 04/Apr/2012

Abstract:

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent

a drug delivery method with the use of the same

a drug containing the same

and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

Priority: JP20040382791 Applic. Date: 2004-12-22; US2008-793736 Applic. Date: 2008-04-08; WO2005JP23619 Applic. Date: 2005-12-22

Inventor: NIITSU YOSHIRO [JP]; KATO JUNJI [JP]; SATO YASUSHI [JP]


Application No.: US20120195968A1  Published: 02/Aug/2012

Title: CONTROLLED-RELEASE MELATONIN COMPOSITIONS AND RELATED METHODS

Applicant/Assignee:

Application No.: 13/359638   Filing Date: 27/Jan/2012

Abstract:

This disclosure relates to controlled-release melatonin compositions and related methods. In one embodiment, a controlled-release medicament composition comprises melatonin dispersed in a controlled melatonin release portion comprising a polymer matrix, the polymer matrix adapted to encapsulate the melatonin in a melatonin solubility enhancing pH environment and to maintain the melatonin solubility enhancing pH environment when the composition is located in a melatonin solubility diminishing pH environment for allowing an effective amount of melatonin to be released into the melatonin solubility diminishing pH environment.

Priority: US201161437217P Applic. Date: 2011-01-28

Inventor: SHAH SYED M [US]; HASSAN DANIEL [US]


Application No.: US20120196873A1  Published: 02/Aug/2012

Title: STABILIZATION OF AMORPHOUS DRUGS USING SPONGE-LIKE CARRIER MATRICES

Applicant/Assignee: CAPSULUTION NANOSCIENCE AG

Application No.: 13/000133   Filing Date: 19/Jun/2009

Abstract:

The present invention relates to drug formulations for the stabilization of amorphous forms of drugs. In particular the present invention relates to pharmaceutical compositions comprising sponge-like carrier matrices, particularly polyelectrolyte complexes or porous particles. The invention also relates to methods for the production of such pharmaceutical compositions.

Priority: EP20080158678 Applic. Date: 2008-06-20; WO2009EP57688 Applic. Date: 2009-06-19

Inventor: NOLTE MARC [DE]; MAYER JOERG [DE]; GONZALEZ FERREIRO MARIA [NL]; ASSOGBA-ZANDT ANNETTE [DE]; FEHRING VOLKER [DE]; KROEHNE LUTZ [DE]; VOIGT ANDREAS [DE]; DUNMANN CHRISTOPH [DE]


Application No.: US20120196942A1  Published: 02/Aug/2012

Title: NOVEL LIQUID CRYSTAL COMPOSITION

Applicant/Assignee:

Application No.: 13/499344   Filing Date: 29/Sep/2010

Abstract:

A liquid crystal composition contains liquid crystals containing one kind of or two or more kinds of silicone surfactants, a phenyl-modified silicone oil and water. The liquid crystal composition of the present invention contains 5 to 95% by weight in total of one kind of or two or more kinds of silicone surfactants, 0.1 to 90% by weight of a phenyl-modified silicone oil and 0.1 to 90% by weight of water. The liquid crystal composition of the present invention can solubilize hydrophobic compounds having poor solubility (for example, hydrocarbon oils such as squalane, fatty acids such as oleic acid and lipoic acid and ester oils such as cetyl isooctanoate) and is thus useful, for example, as toiletry materials and cosmetic materials.

Priority: JP20090226918 Applic. Date: 2009-09-30; WO2010JP05863 Applic. Date: 2010-09-29

Inventor: YAMAGUCHI YOKO [JP]; YAMASHITA YUJI [JP]; HAMASAKI TAKESHI [JP]


Application No.: US20120201849A1  Published: 09/Aug/2012

Title: VACCINE STABILIZER

Applicant/Assignee: XCELLEREX, INC

Application No.: 13/355158   Filing Date: 20/Jan/2012

Abstract:

Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms

an inorganic salt

glutamic acid or a salt thereof

a polyol

a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilisation.

Priority: WO2010US43019 Applic. Date: 2010-07-23; US2009-229153P Applic. Date: 2009-07-28

Inventor: SUN TIANXIAO [US]; LEVESQUE PHILIP M [US]; BROWN ALICJA T [US]; LEE CYNTHIA K [US]


Application No.: US20120201890A1  Published: 09/Aug/2012

Title: METHODS AND COMPOSITIONS TO SUPPORT TRANSPLANTED TISSUE INTEGRATION AND INNOSCULATION WITH ADIPOSE STROMAL CELLS

Applicant/Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC

Application No.: 13/502090   Filing Date: 13/Oct/2010

Abstract:

The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. In some embodiments, the SVF cells can be on the surface or embedded within a three-dimensional matrix. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.

Priority: US2009-251060P Applic. Date: 2009-10-13; WO2010US52496 Applic. Date: 2010-10-13

Inventor: WILLIAMS STUART K [US]; HOYING JAMES BEATLY [US]; KRISHNAN LAXMINARAYANAN [US]


Application No.: US20120201891A1  Published: 09/Aug/2012

Title: TRANSDERMAL DELIVERY PATCH

Applicant/Assignee:

Application No.: 13/501500   Filing Date: 30/Mar/2011

Abstract:

A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.

Priority: US2010-319002P Applic. Date: 2010-03-30; US2010-319007P Applic. Date: 2010-03-30; WO2011AU00358 Applic. Date: 2011-03-30

Inventor: COTTRELL JEREMY [AU]; GAETANO GIACINTO [AU]; EL-TAMIMY MAHMOUD [AU]; KENNEDY NICHOLAS [AU]; GAVIN PAUL DAVID [AU]


Application No.: US20120202780A1  Published: 09/Aug/2012

Title: CARRIER COMPOSITION

Applicant/Assignee:

Application No.: 13/501494   Filing Date: 22/Dec/2010

Abstract:

A carrier composition of the present invention comprises a phosphate compound of an electron transfer agent and a relatively high concentration of a polar protic solvent. A biologically active compound may be formulated with a carrier composition of the present invention to provide a formulation.

Priority: US2009-289507P Applic. Date: 2009-12-23; WO2010AU01719 Applic. Date: 2010-12-22

Inventor: GAVIN PAUL DAVID [AU]; EL-TAMIMY MAHMOUD [AU]; COTTRELL JEREMY JAMES [AU]; GAETANO GIACINTO [AU]; KENNEDY NICHOLAS JOHN [AU]


Application No.: US20120202893A1  Published: 09/Aug/2012

Title: Method Of Manufacturing A Purified Product Of Alkyl-Modified Polydimethylsiloxane, A Cosmetic Raw Material, And Cosmetics

Applicant/Assignee:

Application No.: 13/395390   Filing Date: 08/Sep/2010

Abstract:

To provide a method for manufacturing a purified product of an alkyl-modified polydimethylsiloxane that is practically odorless and compatible with other cosmetic raw materials. The manufacturing method comprises the steps of: [A] synthesizing an alkyl-modified polydimethylsiloxane by subjecting a hydrosilyl-containing polydimethylsiloxane and an C2-C30 [alpha]-olefin to a hydrosilation reaction, and [B] subjecting the crude alkyl-modified polydimethylsiloxane obtained in Step [A] to a treatment of rendering it odorless by a hydrogenation reaction in the presence of a hydrogenation catalyst in an organic solvent (c) that is essentially free of active hydrogen atoms and has a boiling point equal to or greater than 70 DEG C.

Priority: JP20090208768 Applic. Date: 2009-09-10; WO2010JP65892 Applic. Date: 2010-09-08

Inventor: NOMURA YASUO [JP]; NISHINO KEISUKE [JP]; KANZAKI YASUE [JP]


Application No.: US20120207697A1  Published: 16/Aug/2012

Title: Novel Quinazoline Compounds and Their Use in Perfume Compositions

Applicant/Assignee:

Application No.: 13/027314   Filing Date: 15/Feb/2011

Abstract:

The present invention relates to novel quinazoline compounds and their use in perfume compositions. The novel quinazoline compounds of the present invention are represented by the following formula: an isomer or a mixture of isomers thereof, wherein the broken line represents a single or double bond.

Priority:

Inventor: MONTELEONE MICHAEL G [US]; BELKO ROBERT P [US]; SCHIET FRANC T [NL]; JONES PAUL D [US]; LEVORSE JR ANTHONY T [US]


Application No.: US20120207698A1  Published: 16/Aug/2012

Title: NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN PERFUME COMPOSITIONS

Applicant/Assignee:

Application No.: 13/430908   Filing Date: 27/Mar/2012

Abstract:

The present invention relates to novel pyrimidine derivatives and their use in perfume compositions. The novel pyrimidine derivatives of the present invention are represented by the following formula: wherein when R1 represents H, R2 represents a substituted indanyl selected from the group consisting of or wherein R1 and R2 taken together represent a group of the formula:

Priority: US201113027314 Applic. Date: 2011-02-15

Inventor: BELKO ROBERT P [US]; LEVORSE JR ANTHONY T [US]; NARULA ANUBHAV P S [US]; MONTELEONE MICHAEL G [US]


Application No.: US20120207738A1  Published: 16/Aug/2012

Title: Pretreatment of Post Exposure Treatment for Exposure to a Toxic Substance by Pulmonary Delivery (Inhaler) of a Bioscavenger

Applicant/Assignee:

Application No.: 13/454029   Filing Date: 23/Apr/2012

Abstract:

The present invention relates to a treatment by pulmonary delivery of a bioscavenger to animals as an effective antidote to prevent toxicity produced by exposure of an animal to nerve agents and other toxic substances.

Priority: US2005-128997 Applic. Date: 2005-05-13; WO2003US36117 Applic. Date: 2003-11-13; US2002-425726P Applic. Date: 2002-11-13

Inventor: ROSENBERG YVONNE J [US]


Application No.: US20120207799A1  Published: 16/Aug/2012

Title: ORAL DELIVERY VEHICLE AND MATERIAL

Applicant/Assignee: FOODSOURCE LURES CORPORATION

Application No.: 13/457604   Filing Date: 27/Apr/2012

Abstract:

Natural, biodegradable compositions are described as well as methods for their manufacture. Fishing lures and other items made of the biodegradable materials disintegrate over time in fresh or salt water to reduce pollution. The materials are digestable by fish and other aquatic animals, reducing potential harm to the animal from ingesting a fishing lure or other item made from the natural biodegradable materials disclosed. Because the material is digestable, it can also be used as a food source or supplement for fish and aquatic animals.

Priority: US2008-909848 Applic. Date: 2008-05-13; WO2006US11428 Applic. Date: 2006-03-28; US2005-665703P Applic. Date: 2005-03-28

Inventor: ROGERS ED [US]; GILBERT ROY W [US]


Application No.: US20120207835A1  Published: 16/Aug/2012

Title: BROAD-SPECTRUM BIOCIDE COMPOSITIONS AND A METHOD FOR THEIR PREPARATION

Applicant/Assignee: BROMINE COMPOUNDS LTD

Application No.: 13/503524   Filing Date: 18/Oct/2010

Abstract:

The present invention provides biocide compositions, containing DBNPA encapsulated or absorbed in ceramic powders or xerogels, for preventing the formation of biofilms and for incorporating into paints, coatings, plasters, and plastics.

Priority: WO2010IL00848 Applic. Date: 2010-10-18; US2009-255889P Applic. Date: 2009-10-29

Inventor: SHAPIRO EVGENY [IL]; ZOLKOV CHEN [IL]; KHODAKOVSKAYA RIMMA [IL]; EFFENBERGER REINHARD [IL]


Application No.: US20120207836A1  Published: 16/Aug/2012

Title: DRUG DELIVERY SYSTEMS (WAFER) FOR PEDIATRIC USE

Applicant/Assignee: BAYER PHARMA AKTIENGESELLSCHAFT

Application No.: 13/391377   Filing Date: 19/Aug/2010

Abstract:

The present invention describes drug delivery compositions in the form of thin water-soluble films (wafers), which contain particles that comprise at least one active ingredient-which is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate-and at least one protective agent. The protective agent provides effective taste-masking of the active ingredient due to limited release of the active ingredient in the mouth. The active ingredient is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route. The particles contained in the wafer provided by the present invention have a particle size of below 40 [mu]m thereby resulting in an acceptable sensation in the mouth while dissolving. Such wafers are especially suitable for pediatric use.

Priority: EP20090075378 Applic. Date: 2009-08-19; EP20090075381 Applic. Date: 2009-08-20; WO2010EP05083 Applic. Date: 2010-08-19

Inventor: GENERAL SASCHA [DE]; TEREBESI LLDIKO [DE]; FUNKE ADRIAN [DE]


Application No.: US20120210452A1  Published: 16/Aug/2012

Title: ALKOXYLATED NON-IONIC ALKANOL ADJUVANT FORMULATIONS AND METHODS FOR MAKING AND USING THE SAME

Applicant/Assignee: FASHION CHEMICALS, GMBH & CO KG

Application No.: 13/398698   Filing Date: 16/Feb/2012

Abstract:

Embodiments include adjuvant formulations containing an alkoxylated alkanol adjuvant having the following alkanol structure: where the total number of carbon atoms of R1 and R2 are from about 3 to about 36, R2 can be hydrogen or C1 to C18, and R2 may or may not be branched, and wherein the alkoxylate is one of ethylene oxide, propylene, or mixture thereof. Further embodiments included methods for making and using the alkoxylated alkanol adjuvant formulations.

Priority: US201161443619P Applic. Date: 2011-02-16

Inventor: LANGLEY JEFFREY TODD [US]; HUDSON GEORGE [US]


Application No.: US20120213697A1  Published: 23/Aug/2012

Title: VERSATILE NANOPARTICULATE BIOMATERIAL FOR CONTROLLED DELIVERY AND/OR CONTAINMENT OF THERAPEUTIC AND DIAGNOSTIC MATERIAL

Applicant/Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY

Application No.: 13/265347   Filing Date: 19/Apr/2010

Abstract:

The invention provides compositions for controlled delivery and/or containment of therapeutic and/or diagnostic agents comprising the agent or agents encapsulated by a matrix containing chitosan, polyethylene glycol (PEG) and/or polyvinyl alcohol (PVA), and tetra-methoxy-ortho-silicate (TMOS) or tetra-ethoxy-ortho-silicate (TEOS), as well as methods for preparing the compositions, and uses of the compositions for therapy and imaging.

Priority: US2009-214237P Applic. Date: 2009-04-21; WO2010US01165 Applic. Date: 2010-04-19

Inventor: FRIEDMAN JOEL M [US]; FRIEDMAN ADAM J [US]; HAN GEORGE [US]; NAVATI MAHANTESH S [US]; DAVIES KEVIN P [US]; TAR MOSES TARNDIE [US]; ALFIERI ALAN A [US]; CASADEVALL ARTURO [US]; DADACHOVA EKATERINA [US]; EISENMAN HELENE C [US]; N A JASMIN [US]; SPRAY DAVID [US]


Application No.: US20120213721A1  Published: 23/Aug/2012

Title: Amphiphilic High Refractive Index Organopolysiloxanes

Applicant/Assignee: WACKER CHEMICAL CORPORATION

Application No.: 13/032883   Filing Date: 23/Feb/2011

Abstract:

Amphiphilic silicons which are dispersible or self-dispersing in water, have a high refractive index, and are prepared by a hydrosilylation reaction, resulting in products which are free of cyclic organopolysiloxanes. The high refractive index and dispersibility make the amphiphilic silicones useful in personal care and cosmetics where high shine or gloss is desired.

Priority:

Inventor: ROY AROOP KUMAR [US]; COFFEY MICHAEL LEE [US]


Application No.: US20120213843A1  Published: 23/Aug/2012

Title: COMPOSITION FOR PROMOTING WOUND HEALING

Applicant/Assignee: LIPIDOR AB

Application No.: 13/505502   Filing Date: 03/Nov/2010

Abstract:

A lipid layer forming wound healing promoting composition comprising volatile silicone oil, polar lipid, C2-C4 aliphatic alcohol, and a wound healing agent, in particular a low to medium size natural or synthetic peptide. Also disclosed is a method of forming the lipid layer on a wound and a medical patch provided with the composition.

Priority: SE20090001408 Applic. Date: 2009-11-03; SE20100000022 Applic. Date: 2010-01-12; WO2010SE00269 Applic. Date: 2010-11-03

Inventor: CARLSSON ANDERS [SE]; HOLMBACK JAN [SE]


Application No.: US20120219512A1  Published: 30/Aug/2012

Title: VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 13/467770   Filing Date: 09/May/2012

Abstract:

The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.

Priority: JP20050197205 Applic. Date: 2005-07-06; US2008-988237 Applic. Date: 2008-01-03; WO2006JP313799 Applic. Date: 2006-07-05

Inventor: ISHIDA KENYA [JP]; AIDA TAKASHI [JP]


Application No.: US20120219541A1  Published: 30/Aug/2012

Title: Therapeutic Compositions Comprising Monoterpenes

Applicant/Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA

Application No.: 13/468970   Filing Date: 10/May/2012

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

Priority: US2010-700614 Applic. Date: 2010-02-04; US2009-150714P Applic. Date: 2009-02-06

Inventor: CHEN THOMAS C [US]; DA FONSECA CLOVIS O [BR]; DOS SANTOS THEREZA QUIRICO [BR]; SCHWARTSMANN GILBERTO [BR]


Application No.: US20120219627A1  Published: 30/Aug/2012

Title: COMPOSITIONS AND IMPROVED SOFT TISSUE REPLACEMENT METHODS

Applicant/Assignee: ALLERGAN, INC

Application No.: 13/398680   Filing Date: 16/Feb/2012

Abstract:

The specification discloses compositions and methods for treating a soft tissue defect of an individual.

Priority: US201113193744 Applic. Date: 2011-07-29; US201161445928P Applic. Date: 2011-02-23; US2010-375144P Applic. Date: 2010-08-19

Inventor: VAN EPPS DENNIS E [US]; JIANG GUANG-LIANG [US]; COLLETTE ADAM L [US]; HORAN REBECCA L [US]; CHEN JINGSONG [US]; ALTMAN GREGORY H [US]; IM WHA BIN [US]


Application No.: US20120219628A1  Published: 30/Aug/2012

Title: FAST DISSOLVING SOLID DOSAGE FORM

Applicant/Assignee: IX BIOPHARMA PTE LTD

Application No.: 13/504309   Filing Date: 26/Oct/2010

Abstract:

There is provided a fast dissolving solid dosage form adapted for the release of a biologically active material in the oral cavity wherein the dosage form comprises at least one biologically active material, and at least one matrix forming agent, wherein the dosage form substantially dissolves in the oral cavity. A method of producing the same and a kit comprising the same are also provided.

Priority: SG20090007221 Applic. Date: 2009-10-30; WO2010SG00409 Applic. Date: 2010-10-26

Inventor: LIM CHIN BENG STEPHEN [AU]; SUNDERLAND VIVIAN BRUCE [AU]; LEE YIP HANG EDDY [SG]


Application No.: US20120220628A1  Published: 30/Aug/2012

Title: TABLETS COMPRISING A TASTE MASKING AGENT

Applicant/Assignee: HEXAL AG

Application No.: 13/393779   Filing Date: 12/Apr/2010

Abstract:

The present invention is directed to a tablet comprising at least one bitter tasting and/or mucosa numbness causing pharmaceutically active compound

and at least one zinc salt. In addition, the present invention relates to the use of a zinc salt to reduce or mask the bitter taste of or the numbness of the mucosa caused by pharmaceutically active compounds.

Priority: EP20090158107 Applic. Date: 2009-04-17; WO2010EP54759 Applic. Date: 2010-04-12

Inventor: STORM KLAUS [DE]


Application No.: US20120225095A1  Published: 06/Sep/2012

Title: PRODUCTION OF CARBOXYLIC ACID AND SALT CO-PRODUCTS

Applicant/Assignee: MICHIGAN BIOTECHNOLOGY INSTITUTE

Application No.: 13/039913   Filing Date: 03/Mar/2011

Abstract:

This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C2-C12 carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.

Priority:

Inventor: HANCHAR ROBERT J [US]; KLEFF SUSANNE [US]; GUETTLER MICHAEL V [US]


Application No.: US20120225102A1  Published: 06/Sep/2012

Title: PERFLUOROCARBON GEL FORMULATIONS

Applicant/Assignee: OXYGEN BIOTHERAPEUTICS, INC

Application No.: 13/447874   Filing Date: 16/Apr/2012

Abstract:

A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.

Priority: US2009-205499P Applic. Date: 2009-01-21; US2009-204785P Applic. Date: 2009-01-09; US2008-200254P Applic. Date: 2008-11-25; US2009-589202 Applic. Date: 2009-10-19; WO2009US06159 Applic. Date: 2009-11-17

Inventor: KLEIN GERALD [US]; KIRAL RICHARD [US]; STERN CHRIS J [US]


Application No.: US20120225783A1  Published: 06/Sep/2012

Title: ADJUVANT FOR AGRICULTURAL CHEMICALS

Applicant/Assignee: CJB INDUSTRIES, INC

Application No.: 13/498341   Filing Date: 09/Sep/2010

Abstract:

The present invention provides adjuvant chemical compositions that increase the effectiveness of a wide array of agricultural chemicals. Specifically, the present adjuvant compositions may increase the effectiveness of the normal, accepted amounts of an agricultural chemical per acre. Alternatively, the present adjuvant compositions may obtain similar results upon application of a decreased amount an agricultural chemical per acre. Compositions are also provided that comprise, in addition to the adjuvant compositions, at least one agricultural chemical. The present invention further provides methods of preparation and use thereof.

Priority: US2009-287313P Applic. Date: 2009-12-17; WO2010US48218 Applic. Date: 2010-09-09; US2009-247089P Applic. Date: 2009-09-30

Inventor: HARRIS MICHAEL CLAUDE [US]


Application No.: US20120225952A1  Published: 06/Sep/2012

Title: NON-AQUEOUS SILICONE-BASED OPHTHALMIC FORMULATIONS

Applicant/Assignee:

Application No.: 13/411059   Filing Date: 02/Mar/2012

Abstract:

Non-aqueous compositions including a silicone based excipient and methods of their use are provided. The non-aqueous compositions, products and methods of the present invention are particularly useful for the treatment of ophthalmic diseases

Priority: US201161448899P Applic. Date: 2011-03-03; US201161529553P Applic. Date: 2011-08-31; US201161565447P Applic. Date: 2011-11-30; US201161448890P Applic. Date: 2011-03-03

Inventor: WARNER KEVIN S [US]; PARASHAR AJAY [US]


Application No.: US20120231047A1  Published: 13/Sep/2012

Title: THERAPEUTIC AGENT DELIVERY FOR THE TREATMENT OF ASTHMA VIA IMPLANTABLE AND INSERTABLE MEDICAL DEVICES

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 13/480227   Filing Date: 24/May/2012

Abstract:

Methods for the treatment of asthma are provided, which comprise: (a) providing an implantable or insertable medical device that comprises an asthma treatment agent

and (b) inserting or implanting the medical device within the lungs (e.g., the trachea or the bronchial tree) of a patient, whereupon the therapeutic agent is delivered to the patient in an amount effective to reduce or eliminate the symptoms of asthma. Also disclosed herein are medical devices and kits for carrying out such methods.

Priority: US2007-726608 Applic. Date: 2007-03-22; US2006-839752P Applic. Date: 2006-08-24

Inventor: HERRMANN ROBERT A [US]; DAMARATI JOHN J [US]; HASHEMI SEPIDEH [US]; NAIMARK WENDY [US]; GELLMAN BARRY N [US]; RIOUX ROBERT [US]; ROUSSEAU ALEXANDRA [US]; LAREAU RAYMOND [US]


Application No.: US20120231071A1  Published: 13/Sep/2012

Title: NATURAL PRODUCT INHIBITORS OF 3DG

Applicant/Assignee:

Application No.: 13/479419   Filing Date: 24/May/2012

Abstract:

Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Priority: US2009-474904 Applic. Date: 2009-05-29; US2008-057398P Applic. Date: 2008-05-30

Inventor: TOBIA ANNETTE [US]; ALICE MARCY [US]; SU BANGYING [US]; NIWA TAKASHI [JP]


Application No.: US20120231075A1  Published: 13/Sep/2012

Title: ABUSE-RESISTANT OPIOID DOSAGE FORM

Applicant/Assignee: ENDO PHARMACEUTICALS INC

Application No.: 13/473946   Filing Date: 17/May/2012

Abstract:

We provide a pharmaceutical dosage form including an opioid antagonist surrounded by a controlled release matrix and an opioid agonist in a surrounding matrix.

Priority: US2010-894614 Applic. Date: 2010-09-30; US2002-143140 Applic. Date: 2002-05-10; US2001-290438P Applic. Date: 2001-05-11

Inventor: KAO HUAI-HUNG [US]; ZENG YADI [US]; HOWARD-SPARKS MICHELLE [US]; JIM FAI [US]


Application No.: US20120231079A1  Published: 13/Sep/2012

Title: METHODS AND COMPOSITIONS FOR CONTROLLED DELIVERY OF PHYTOCHEMICAL AGENTS

Applicant/Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC

Application No.: 13/429601   Filing Date: 26/Mar/2012

Abstract:

Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical agent and one or more additional therapeutic agents. Methods of treating a cancer using the compositions are further provided.

Priority: US2009-401175 Applic. Date: 2009-03-10; US2008-035153P Applic. Date: 2008-03-10; US2008-096108P Applic. Date: 2008-09-11

Inventor: GUPTA RAMESH C [US]; VADHANAM MANICKA V [US]; AQIL FARRUKH [US]


Application No.: US20120232164A1  Published: 13/Sep/2012

Title: FIBROUS CALCIUM PYROPHOSPHATE PARTICLES AND METHODS OF MAKING AND USING SAME

Applicant/Assignee: NANUNANU LTD

Application No.: 13/307867   Filing Date: 30/Nov/2011

Abstract:

Fibrous calcium pyrophosphate particles with a unique fibrous nanostructure are disclosed. The invention includes a composition, comprising fibrous particles, wherein the fibrous particles include fibers and the fibers include calcium and pyrophosphate. Also included are methods for making calcium pyrophosphate particles wherein solutions of calcium salt and pyrophosphate salt are combined to form the particles. Pharmaceutical compositions and methods for treating a patent using the disclosed particles are also described.

Priority: US2009-373198 Applic. Date: 2009-04-16; WO2007CA01221 Applic. Date: 2007-07-11; US2006-830252P Applic. Date: 2006-07-12

Inventor: GROVER LIAM M [GB]; BARRALET JAKE E [CA]


Application No.: US20120232165A1  Published: 13/Sep/2012

Title: Cleaning composition having high self-adhesion and providing residual benefits

Applicant/Assignee: S.C. JOHNSON & SON, INC

Application No.: 13/374874   Filing Date: 20/Jan/2012

Abstract:

A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter

(b) at least one surfactant selected from the group consisting of: anionic, non-ionic, cationic, amphoteric, zwitterionic, and combinations thereof

(c) mineral oil

(d) a blend of linear primary alcohols, wherein each alcohol of said blend includes a carbon chain containing 9 to 17 carbons or an ethoxylated blend thereof

(e) water

(f) optionally, at least one solvent

and wherein the composition is self-adhering upon application to a surface to be treated, and wherein the composition provides a wet film to said surface when water passes over said composition and surface.

Priority: US2009-461102 Applic. Date: 2009-07-31; US2008-064182P Applic. Date: 2008-02-21; US2009-388576 Applic. Date: 2009-02-19

Inventor: KLINKHAMMER MICHAEL E [US]; WORTLEY RUSSELL B [US]; STRASH THOMAS A [US]


Application No.: US20120237557A1  Published: 20/Sep/2012

Title: BIOACTIVE CARBON-NANOTUBE AGAROSE COMPOSITES FOR NEURAL ENGINEERING

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 13/308510   Filing Date: 30/Nov/2011

Abstract:

Nanocomposite fibers containing one or more carbon nanotubes encapsulated in an polysaccharide gel matrix.

Priority: US2010-417913P Applic. Date: 2010-11-30

Inventor: LEWITUS DAN [IL]; KOHN JOACHIM B [US]; NEIMARK ALEXANDER [US]; LANDERS JOHN [US]


Application No.: US20120237577A1  Published: 20/Sep/2012

Title: Black Effect Pigment

Applicant/Assignee:

Application No.: 13/419772   Filing Date: 14/Mar/2012

Abstract:

This disclosure is directed to a black effect pigment and a method of forming said pigment. The pigment comprises a platy substrate coated with SnO2 and/or SnO2 hydrates and Fe3O4 with an optional coating of metal oxides such as SiO2, TiO2, ZrO2 and ZnO2. The deposition of the SnO2 and/or SnO2 hydrates onto the substrate improves the adhesion and prepares the substrate surface for deposition of the iron oxides onto the platy surface, especially mica surfaces. While the pigment may be used in such applications as coating, powder coating, printing ink, plastic, ceramic material, glass, cosmetic formulation, laser marking pigment, pigment composition or dry preparation, the pigment is especially suitable for cosmetic applications.

Priority: US201161452804P Applic. Date: 2011-03-15

Inventor: SIOSS JAMES [US]; CHIRAYIL THOMAS [US]; AUCAR BETTY [US]


Application No.: US20120237603A1  Published: 20/Sep/2012

Title: ABUSE-RESISTANT OPIOID DOSAGE FORM

Applicant/Assignee: ENDO PHARMACEUTICALS INC

Application No.: 13/480737   Filing Date: 25/May/2012

Abstract:

We provide a pharmaceutical dosage form including an opioid antagonist surrounded by a controlled release matrix and an opioid agonist in a surrounding matrix.

Priority: US201113033899 Applic. Date: 2011-02-24; US2010-894614 Applic. Date: 2010-09-30; US2002-143140 Applic. Date: 2002-05-10; US2001-290438P Applic. Date: 2001-05-11

Inventor: KAO HUAI-HUNG [US]; ZENG YADI [US]; HOWARD-SPARKS MICHELLE [US]; JIM FAI [US]


Application No.: US20120244088A1  Published: 27/Sep/2012

Title: ORGANOMODIFIED CARBOSILOXANE MONOMERS CONTAINING COMPOSITIONS AND USES THEREOF

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS INC

Application No.: 13/052288   Filing Date: 21/Mar/2011

Abstract:

There is provided novel mono-acrylate functionalized siloxane monomer containing carbosiloxane linkage for improved hydrolysis resistance. This invention also provides copolymers produced using these monomers and their use in various applications.

Priority:

Inventor: SAXENA ANUBHAV [IN]; SENTHILKUMAR UMPATHY [IN]; LEWIS KENRICK M [US]


Application No.: US20120244221A1  Published: 27/Sep/2012

Title: EXTENDED-RELEASE FORMULATION FOR REDUCING THE FREQUENCY OF URINATION AND METHOD OF USE THEREOF

Applicant/Assignee: WELLESLEY PHARMACEUTICALS, LLC

Application No.: 13/487348   Filing Date: 04/Jun/2012

Abstract:

Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent formulated for extended-release.

Priority: US201213424000 Applic. Date: 2012-03-19; US201213343332 Applic. Date: 2012-01-04; US2010-956634 Applic. Date: 2010-11-30; US2010-362374P Applic. Date: 2010-07-08

Inventor: DILL DAVID A [US]


Application No.: US20120245107A1  Published: 27/Sep/2012

Title: METHODS OF REDUCING THE PROLIFERATION AND VIABLILITY OF MICROBIAL AGENTS

Applicant/Assignee: TARGETED DELIVERY TECHNOLOGIES LIMITED

Application No.: 13/491474   Filing Date: 07/Jun/2012

Abstract:

The invention relates to formulations of an antimicrobial agent, a lipid, and optionally a surfactant, and uses thereof for reducing the proliferation and viability of microbial agents.

Priority: US2009-508494 Applic. Date: 2009-07-23; US2009-150288P Applic. Date: 2009-02-05

Inventor: HENRY WILLIAM [GB]; KROON HENK-ANDRE [US]; SUMMERTON LINDA [GB]


Application No.: US20120245156A1  Published: 27/Sep/2012

Title: ORAL LYOPHILIZED COMPOSITIONS

Applicant/Assignee: CEPHALON FRANCE

Application No.: 13/487438   Filing Date: 04/Jun/2012

Abstract:

The present invention relates to a method for preparing an oral lyophilizate composition comprising: a) forming a liquid phase by using at least one homogenising agent having tensioactive properties, said liquid phase comprising at least an active pharmaceutical ingredient, a filler and/or a binding agent and a solvent, b) lyophilizing said liquid phase to form the oral lyophilizate composition.

Priority: EP20100305053 Applic. Date: 2010-01-18

Inventor: NGUYEN THANH-TAM [FR]


Application No.: US20120247993A1  Published: 04/Oct/2012

Title: Probiotic Compositions, Methods and Apparatus for Their Administration

Applicant/Assignee: UNISTRAW PATENT HOLDINGS LIMITED

Application No.: 13/509127   Filing Date: 13/Nov/2009

Abstract:

A probiotic composition including a probiotic microorganism embedded within a matrix, the matrix substantially maintaining the viability of said microorganisms. The matrix releases said microorganisms into and upon contact with a liquid carrier. The invention includes methods for manufacturing the composition, particular forms of the composition (2) and as apparatus for administration.

Priority: AU20080906124 Applic. Date: 2008-11-26; AU20080905905 Applic. Date: 2008-11-14; WO2009AU01484 Applic. Date: 2009-11-13

Inventor: PALAZZI KEN [AU]; STYAN MARK [AU]; WALLIS KRISTEL [AU]; SOFJAN JENNI [AU]; LI YIN [AU]; CONWAY PATRICIA [AU]


Application No.: US20120251460A1  Published: 04/Oct/2012

Title: USE OF VANILLIN DERIVATIVES AS A PRESERVATIVE, PRESERVATION METHOD, COMPOUNDS, AND COMPOSITION

Applicant/Assignee: L'OREAL

Application No.: 13/499503   Filing Date: 16/Sep/2010

Abstract:

The present invention relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I): in which: R2 represents a hydrogen atom or a methyl or ethyl radical

R3 represents a linear C1-C12 alkyl radical, optionally substituted with a hydroxyl group

or a linear C2-C12 alkenyl radical, optionally substituted with a hydroxyl group

as a preserving agent. The invention also relates to certain novel compounds and to the cosmetic, dermatological or pharmaceutical compositions comprising them.

Priority: FR20090056843 Applic. Date: 2009-10-01; WO2010FR51926 Applic. Date: 2010-09-16

Inventor: DALKO MARIA [FR]


Application No.: US20120251521A1  Published: 04/Oct/2012

Title: Technical field and industrial applicability of the invention

Applicant/Assignee:

Application No.: 13/078930   Filing Date: 02/Apr/2011

Abstract:

The present invention is a solution or colloid of fullerene, SWNTs, or graphene in cyclic terpenes, lactones, terpene-alcohol, fatty-acid alcohols, and lactones following ultrasonication and ultracentrifugation processing, for oil-energy, biological, electrical-thermal applications. The compositions are useful as fuel/oil/grease/gels (synthetic included), oil/fuel/additives/propellants, identification dyes, and heat-transfer fluids. Other functions are phase-change fluids for solar energy power plants, antifreeze, electronic dyes, electrolytic fluid/solvent, electrically-thermally conductive material for electrochemical, dielectric, filler/adhesive for semiconductor, eletro-optical, and liquid crystal substrates/coatings for touch sensitive transmissive or reflective displays. When combined with gelatin the formulations can function as dichroic-optical coatings for thin-films/waveguides/holograms. Such formulations may also be used as photovoltaic paint, electrorheological, thermophoretic-thermodiffusion, electrohydrodynamics, electric propulsion, laser enhancement, plasma jets, and magnetohydrodynamics. Energy use includes high-temperature superconductivity, or hydrogen storage using carbon, alumina, or silica supported Pd, Pt, or Zn catalysts. Biological applications include anticancer, antiviral, antifungal, drug delivery, skin permeable agents, and lubricant use.

Priority:

Inventor: ROSTRO BERTHA [US]; KOHANLOO MEHDIE [US]


Application No.: US20120251594A1  Published: 04/Oct/2012

Title: Delivery of Submicrometer and Nanometer Aerosols to the Lungs Using Hygroscopic Excipients or Dual Stream Nasal Delivery

Applicant/Assignee:

Application No.: 13/503927   Filing Date: 09/Nov/2010

Abstract:

Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung.

Priority: US2009-259292P Applic. Date: 2009-11-09; US2010-306105P Applic. Date: 2010-02-19; WO2010US55940 Applic. Date: 2010-11-09

Inventor: LONGEST PHILIP WORTH [US]; HINDLE MICHAEL [US]


Application No.: US20120251607A1  Published: 04/Oct/2012

Title: ANTIMICROBIAL COMPOSITIONS, METHODS OF PREPARATION THEREOF, AND USES THEREOF

Applicant/Assignee:

Application No.: 13/077005   Filing Date: 31/Mar/2011

Abstract:

A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group

and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment

wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.

Priority:

Inventor: COADY DANIEL J [US]; FUKUSHIMA KAZUKI [US]; HEDRICK JAMES L [US]; YANG YI YAN [US]


Application No.: US20120258150A1  Published: 11/Oct/2012

Title: PARTICLES COMPRISING VOLATILE MATERIALS AND PARTICLE GAS SATURATED SOLUTION PROCESSES FOR MAKING SAME

Applicant/Assignee:

Application No.: 13/433341   Filing Date: 29/Mar/2012

Abstract:

Particles containing a polymer and a volatile material, such as a perfume, and particle gas saturated solution (PGSS) processes for making such particles are provided.

Priority: US201161474007P Applic. Date: 2011-04-11

Inventor: RAUCKHORST HOLLY BALASUBRAMANIAN [US]; D ACCHIOLI VICENZO [IT]; DREHER ANDREAS JOSEF [US]


Application No.: US20120258174A1  Published: 11/Oct/2012

Title: Methods for Treating Bacterial Infection

Applicant/Assignee: INNOCOLL TECHNOLOGIES LIMITED

Application No.: 13/085585   Filing Date: 13/Apr/2011

Abstract:

This invention relates to methods for treating bacterial infection, which methods find utility in the treatment of, for example, infected ulcers, optionally infected diabetic ulcers. In particular, this invention relates to treating bacterial infection, for example, infected diabetic ulcers by topical administration of at least one aminoglycoside antibiotic at the site of infection, in combination with at least one antibacterial agent, which antibacterial agent is administered remote from the site of infection, preferably administered systemically. In a particular embodiment, the present invention relates to a composition for use in treating bacterial infection, the composition comprising gentamicin sulphate (a water-soluble broad-spectrum aminoglycoside antibiotic) uniformly dispersed in a type-I collagen matrix

in combination with at least one systemically-administered antibacterial agent. The present invention provides bactericidal activity against most strains of aerobic gram-negative and gram-positive and facultative anaerobic gram-negative pathogens, including methicillin-resistant Staphylococcus aureus.

Priority: EP20110161898 Applic. Date: 2011-04-11

Inventor: PRIOR DAVID [IE]


Application No.: US20120259252A1  Published: 11/Oct/2012

Title: Coupling Emulsions for Use With Ultrasound Devices

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 13/514794   Filing Date: 15/Oct/2010

Abstract:

Methods and cosmetic coupling compositions are provided that can be effectively used in conjunction with an ultrasound or similar device. The compositions and methods allow extended manipulation on the skin and heating without breaking down, pilling or balling and while maintaining a pleasant cosmetic feel and leaving skin feeling soft.

Priority: WO2010US52803 Applic. Date: 2010-10-15; US2009-289194P Applic. Date: 2009-12-22

Inventor: THORN-LEESON DANIEL [US]; MEI BING C [US]; GARRISON MARK S [US]; LAMBERTY LISA [US]; MILOW CLIFFORD A [US]


Application No.: US20120263792A1  Published: 18/Oct/2012

Title: DUAL DRUG DOSAGE FORMS WITH IMPROVED SEPARATION OF DRUGS

Applicant/Assignee: DEPOMED, INC

Application No.: 13/530631   Filing Date: 22/Jun/2012

Abstract:

Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing lull access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.

Priority: US2003-623481 Applic. Date: 2003-07-18

Inventor: LIM JONG [US]; SHELL JOHN N [US]; LOUIE-HELM JENNY [US]


Application No.: US20120264681A1  Published: 18/Oct/2012

Title: BUFFERED OPHTHALMIC COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee: HEALOR LTD

Application No.: 13/291553   Filing Date: 08/Nov/2011

Abstract:

The present disclosure provides a buffered ophthalmic composition for formulation of topically administrable suspensions useful for treating eye disorders by promoting wound healing, delivery of pharmaceutically active agents, and lubricating the eye. In particular the ophthalmic composition includes a buffer solution compatible with application to a mammalian eye, wherein the buffer provides increased mechanism of action of pharmaceutically active agents as well as therapeutic qualities. The ophthalmic composition exhibits dual therapeutic action to alleviate various eye disorders as it concomitantly treats corneal ulcerations and excessive inflammation which results from various eye injuries.

Priority: US2010-411464P Applic. Date: 2010-11-08; US2010-411466P Applic. Date: 2010-11-08

Inventor: BRAIMAN-WIKSMAN LIORA [IL]; SAGIV YUVAL [IL]; LEVY-HACHAM OFRA [IL]; TENNENBAUM TAMAR [IL]


Application No.: US20120265001A1  Published: 18/Oct/2012

Title: COMPOSITE MAGNETIC NANOPARTICLE DRUG DELIVERY SYSTEM

Applicant/Assignee: WICHITA STATE UNIVERSITY

Application No.: 13/271172   Filing Date: 11/Oct/2011

Abstract:

A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.

Priority: US2010-392018P Applic. Date: 2010-10-11

Inventor: ASMATULU RAMAZAN [US]; MISAK HEATH [US]; YANG SHANG-YOU [US]; WOOLEY PAUL [US]


Application No.: US20120269722A1  Published: 25/Oct/2012

Title: CHEMOEMBOLISATION

Applicant/Assignee: BIOCOMPATIBLES UK LIMITED

Application No.: 13/452337   Filing Date: 20/Apr/2012

Abstract:

A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.

Priority: EP20030250868 Applic. Date: 2003-02-12; US2008-210573 Applic. Date: 2008-09-15; US2006-434274 Applic. Date: 2006-05-16; US2003-366603 Applic. Date: 2003-02-14

Inventor: LEWIS ANDREW LENNARD [GB]; STRATFORD PETER WILLIAM [GB]; LEPPARD SIMON [GB]; GARCIA PEDRO [GB]; HALL BRENDA [GB]; GONZALEZ MARIA VICTORIA FAJARDO [GB]


Application No.: US20120269739A1  Published: 25/Oct/2012

Title: COMPOSITION, USE, AND PRESERVATION METHOD

Applicant/Assignee: L'OREAL

Application No.: 13/499521   Filing Date: 16/Sep/2010

Abstract:

The invention relates to a cosmetic, pharmaceutical, dermatological, nutraceutical or oral cosmetic composition having, as main preserving system, a mild preserving system formed from compounds with a broad antimicrobial spectrum, which have only one pKa, the said pKa being greater than or equal to 10, the said mild preserving system being present in a content strictly greater than or equal to 1% by weight relative to the weight of the said composition. The invention also relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I), as a preserving agent:

Priority: FR20090056833 Applic. Date: 2009-10-01; FR20090058172 Applic. Date: 2009-11-19; US2009-248994P Applic. Date: 2009-10-06; WO2010FR51921 Applic. Date: 2010-09-16

Inventor: DALKO MARIA [FR]; LEREBOUR GERALDINE [FR]; CUPFERMAN SYLVIE [FR]


Application No.: US20120269747A1  Published: 25/Oct/2012

Title: Novel Organopolysiloxane Copolymer

Applicant/Assignee:

Application No.: 13/503447   Filing Date: 10/Oct/2010

Abstract:

A novel organopolysiloxane copolymer is disclosed. The copolymer has excellent surface active power and exhibits excellent blending stability in cosmetic preparations and excellent feeling improvement characteristics in comparison to conventionally known polyether-modified silicones and silicone-containing alternating copolymers. The organopolysiloxane copolymer can be used in combination with various cosmetic formulation ingredients. The copolymer is an AB-type organopolysiloxane copolymer which has a silylalkyl group having a carbosiloxane dendrimer structure at one end of the molecular chain, and a hydrophilic segment at the other end. A method for producing the AB-type organopolysiloxane copolymer

a surfactant and a powder processing agent which are respectively composed of the organopolysiloxane copolymer

and a composition for external application and a cosmetic formulation which respectively contain the organopolysiloxane copolymer are also disclosed.

Priority: JP20090244976 Applic. Date: 2009-10-23; WO2010JP69237 Applic. Date: 2010-10-22

Inventor: IIMURA TOMOHIRO [JP]; HAYASHI AKITO [JP]; TAMURA SEIKI [JP]; FURUKAWA HARUHIKO [JP]


Application No.: US20120269748A1  Published: 25/Oct/2012

Title: Thickening Or Gelling Agent For Oily Raw Materials

Applicant/Assignee:

Application No.: 13/503623   Filing Date: 25/Oct/2010

Abstract:

An excellent oil-thickening or -gelling agent is provided. The agent is compatible with various oils and can freely control the form or viscosity of oily raw materials or cosmetics by changing the quantity thereof added. The agent contains a novel co-modified organopolysiloxane that contains both a group having a siloxane dendron structure and a hydrophilic group and that preferably has a degree of polymerization of 200 or more. A gel composition containing the co-modified organopolysiloxane is also provided. The gel composition is useful as a base that permits stable and easy preparation of cosmetics having various viscoelasticities and forms. An oil is kept in the form of a gel that has a viscoelasticity falling within the intermediate range between the viscoelasticity of liquid and that of solid. Cosmetics containing the thickening or gelling agent are also provided.

Priority: JP20090244977 Applic. Date: 2009-10-23; WO2010JP69248 Applic. Date: 2010-10-25

Inventor: TAMURA SEIKI [JP]; IIMURA TOMOHIRO [JP]; SOUDA TATSUO [JP]; HAYASHI AKITO [JP]; FURUKAWA HARUHIKO [JP]


Application No.: US20120269862A1  Published: 25/Oct/2012

Title: OPHTHALMIC COMPOSITION WITH A VISCOSITY ENHANCEMENT SYSTEM HAVING TWO DIFFERENT VISCOSITY ENHANCING AGENTS

Applicant/Assignee:

Application No.: 13/450613   Filing Date: 19/Apr/2012

Abstract:

An ophthalmic composition is disclosed having a viscosity enhancement system comprised of two different viscosity enhancing agents. The aqueous composition contains a first viscosity enhancing agent that provides enhanced viscosity upon dispensing of the composition to the eye and a second viscosity agent that increases viscosity (e.g., gels or partially gels) after dispensing of the composition to the eye to provide extended viscosity enhancement of the composition.

Priority: US201161478081P Applic. Date: 2011-04-22

Inventor: CHOWHAN MASOOD A [US]; GHOSH MALAY [US]


Application No.: US20120269875A1  Published: 25/Oct/2012

Title: Novel Co-Modified Organopolysiloxane

Applicant/Assignee:

Application No.: 13/503455   Filing Date: 25/Oct/2010

Abstract:

A novel organopolysiloxane having a hydrophilic group, which can be produced easily and is not susceptible to two-phase separation, sedimentation of unreacted materials or the like after production, while being chemically stable and excellently practical, is disclosed. A method for producing the organopolysiloxane

and uses of the organopolysiloxane are also disclosed. The organopolysiloxane is a co-modified organopolysiloxane which has a group having a siloxane dendron structure and a hydrophilic group.

Priority: JP20090244975 Applic. Date: 2009-10-23; WO2010JP69249 Applic. Date: 2010-10-25

Inventor: TAMURA SEIKI [JP]; IIMURA TOMOHIRO [JP]; HAYASHI AKITO [JP]; SOUDA TATSUO [JP]; FURUKAWA HARUHIKO [JP]


Application No.: US20120269886A1  Published: 25/Oct/2012

Title: THERAPEUTIC AGENT FOR PULMONARY FIBROSIS

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 13/491976   Filing Date: 08/Jun/2012

Abstract:

Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid

a therapeutic agent for pulmonary fibrosis, which utilized the carrier

and a preparation kit of the therapeutic agent.

Priority: JP20040382791 Applic. Date: 2004-12-22; JP20080068227 Applic. Date: 2008-03-17; US2010-933075 Applic. Date: 2010-12-10; WO2009JP01148 Applic. Date: 2009-03-16; US201213439330 Applic. Date: 2012-04-04; US2008-793736 Applic. Date: 2008-04-08; WO2005JP23619 Applic. Date: 2005-12-22

Inventor: NIITSU YOSHIRO [JP]; TAKIMOTO RISHU [JP]; MINOMI KENJIRO [JP]; MIYAZAKI MIYONO [JP]; KAJIWARA KEIKO [JP]; TANAKA YASUNOBU [JP]


Application No.: US20120269888A1  Published: 25/Oct/2012

Title: BARRIER COMPOSITION

Applicant/Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Application No.: 13/503068   Filing Date: 20/Oct/2010

Abstract:

The invention is directed to a barrier composition, to a vehicle comprising said barrier composition, to a layer comprising said barrier composition, to a foodstuff comprising said vehicle or layer, to a pharmaceutical or nutraceutical composition comprising said vehicle or layer, to a method for protecting one or more active ingredients, and to the use of said barrier composition. The barrier composition of the invention comprises: a hydrophobic organic phase

and 0.1-75 vol. %, based on the total volume of the barrier composition, of biodegradable solid plate-like particles.

Priority: EP20090173511 Applic. Date: 2009-10-20; WO2010NL50698 Applic. Date: 2010-10-20

Inventor: JETTEN JAN MATTHIJS [NL]; EVERSDIJK JACOBUS [NL]; VAN BOMMEL KJELD JACOBUS CORNELIS [NL]; TIMMERMANS JOHANNES WILHELMUS [NL]; TEN CATE AAFKE TESSA [NL]; SLAGHEK THEODOOR MAXIMILIAAN [NL]


Application No.: US20120269892A1  Published: 25/Oct/2012

Title: IMPLANTABLE COMPOSITIONS AND METHODS FOR PREPARING THE SAME

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 13/090745   Filing Date: 20/Apr/2011

Abstract:

Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture

and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.

Priority:

Inventor: MOSSAAD CHRISTINA [US]; SHIMP LAWRENCE A [US]; WEI GUOBAO [US]; WINTERBOTTOM JOHN [US]


Application No.: US20120269908A1  Published: 25/Oct/2012

Title: CARRIER IN OIL-IN-WATER EMULSION FORM, PARTICULARLY FOR COSMETIC OR DERMATOLOGICAL USE

Applicant/Assignee: OCTALIA TECHNOLOGIES

Application No.: 13/259398   Filing Date: 27/Nov/2009

Abstract:

The present invention relates to a carrier in oil-in-water emulsion form, containing a very small amount of a surface-active agent so that the emulsion is stable, well-tolerated, and nonirritating. The present invention also relates to a method for preparing a carrier according to the invention and to the use of such a carrier as a base for compositions to be applied onto sensitive human or animal body tissue, particularly in dermatological or dermocosmetic compositions.

Priority: FR20080058067 Applic. Date: 2008-11-27; WO2009FR52323 Applic. Date: 2009-11-27

Inventor: SARRAZIN CHRISTIAN [FR]; DO MARINA [FR]; BOIX MICHELE [FR]


Application No.: US20120270933A1  Published: 25/Oct/2012

Title: LIQUID STATIN FORMULATION

Applicant/Assignee: MADEIRA THERAPEUTICS

Application No.: 13/538904   Filing Date: 29/Jun/2012

Abstract:

The present invention relates to compositions and methods for liquid statin products suitable for use in a person or animal. The invention provides stable liquid formulations containing a statin and at least one solubilizer. Methods for the oral administration of statin formulations are also provided by the invention.

Priority: WO2010US21344 Applic. Date: 2010-01-19; US2009-155018P Applic. Date: 2009-02-24

Inventor: PHELPS KEN [US]; QASEM JABAR [US]; GOLD LYNN [US]


Application No.: US20120271361A1  Published: 25/Oct/2012

Title: Functionalized Nanodiamond Reinforced Biopolymers

Applicant/Assignee: DREXEL UNIVERSITY

Application No.: 13/498436   Filing Date: 01/Oct/2010

Abstract:

The present invention includes a composition for implantation in a patient, comprising surface-functionalized nanodiamonds and at least one biodegradable biocompatible polymer. The present invention also includes a surgical fixation device for use in a patient.

Priority: WO2010US51176 Applic. Date: 2010-10-01; US2009-248202P Applic. Date: 2009-10-02

Inventor: ZHOU GONGYAO [US]; LELKES PETER I [US]; GOGOTSI YURY [US]; MOCHALIN VADYM [US]


Application No.: US20120272983A1  Published: 01/Nov/2012

Title: HAIR REMOVAL DEVICE COMPRISING A MODIFYING SURFACTANT

Applicant/Assignee:

Application No.: 13/453016   Filing Date: 23/Apr/2012

Abstract:

A hair removal device is provided comprising an erodable solid moisturizer, the erodable solid moisturizer comprising: a. A modifying surfactant comprising: i. A carbon chain with 12 to 32 carbon atoms

ii. From 1 to 19 ethylene oxide groups

b. At least 50% hydrophobic phase by weight of the erodable solid moisturizer.

Priority: EP20110163702 Applic. Date: 2011-04-26

Inventor: STEPHENS ALISON FIONA [GB]; BAXTER ELAINE ALICE MARIE [GB]; BROOKS ALAN [GB]


Application No.: US20120276026A1  Published: 01/Nov/2012

Title: Volatile Cyclic Siloxanes

Applicant/Assignee:

Application No.: 13/511038   Filing Date: 24/Nov/2010

Abstract:

This application relates to cyclic siloxane compounds comprising the structural formula where a>=2 and b>=2, R is an alkyl group containing 1 to 4 carbon atoms, R1 is independently hydrogen or methyl, compositions comprising any of the above cyclic siloxanes and an additional silicone, emulsion compositions comprising any of the above cyclic siloxanes or the above composition, and a process for preparing the above cyclic siloxane compounds comprising reacting a chloro end-blocked polydimethylsiloxane with a diol functional compound containing at least 3 carbon atoms.

Priority: US2009-264283P Applic. Date: 2009-11-25; WO2010US57962 Applic. Date: 2010-11-24

Inventor: FISHER MARK DAVID [US]; LEE MICHAEL KANG-JEN [US]; ZENG BI-SHUN [US]


Application No.: US20120276164A1  Published: 01/Nov/2012

Title: IMPLANTABLE PASTE AND ITS USE

Applicant/Assignee:

Application No.: 13/509302   Filing Date: 12/Nov/2010

Abstract:

The present invention relates to an implantable paste comprising bioactive glass spheres having a size distribution of 50-425 [mu]m, low molecular weight polyethylene glycol having a molecular weight range of 200-700 g/mol, medium molecular weight polyethylene glycol having a molecular weight range of 700-2500 g/mol and high molecular weight polyethylene glycol having a molecular weight range of 2500-8000 g/mol, with the proviso that the molecular weight of the low molecular weight polyethylene glycol and of the medium molecular weight polyethylene glycol differ from each other by at least 80 g/mol and that the molecular weight of the medium molecular weight polyethylene glycol and of the high molecular weight polyethylene glycol differ from each other by at least 300 g/mol.

Priority: EP20090175775 Applic. Date: 2009-11-12; WO2010EP67376 Applic. Date: 2010-11-12

Inventor: TUOMINEN JUKKA [FI]; LEHTONEN TIMO [FI]; OLLILA FREDRIK [FI]


Application No.: US20120276170A1  Published: 01/Nov/2012

Title: INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE

Applicant/Assignee: NANOHYBRID CO., LTD

Application No.: 13/541413   Filing Date: 03/Jul/2012

Abstract:

Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

Priority: KR20050047235 Applic. Date: 2005-06-02; US2007-915922 Applic. Date: 2007-11-29; WO2005KR01667 Applic. Date: 2005-06-03

Inventor: PARK TAEUN [KR]; CHOY JIN-HO [KR]; OH JAE-MIN [KR]; JUNG JI-SUN [KR]


Application No.: US20120276185A1  Published: 01/Nov/2012

Title: SOLUBLE COATING COMPRISING POLYELECTROLYTE WITH HYDROPHOBIC COUNTERIONS

Applicant/Assignee:

Application No.: 13/544749   Filing Date: 09/Jul/2012

Abstract:

The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.

Priority: US2008-130942 Applic. Date: 2008-05-30

Inventor: HOSSAINY SYED F A [US]; TROLLSAS MIKAEL O [US]; KLEINER LOTHAR W [US]


Application No.: US20120276202A1  Published: 01/Nov/2012

Title: COLLAGEN MATRIX FOR TISSUE ENGINEERING

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 13/096630   Filing Date: 28/Apr/2011

Abstract:

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

Priority:

Inventor: SELIM ABDULHAFEZ A [US]; SHIMP LAWRENCE A [US]; WANG HSIU YING SHERRY [US]


Application No.: US20120276203A1  Published: 01/Nov/2012

Title: COLLAGEN MATRIX FOR CELL THERAPY

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 13/096656   Filing Date: 28/Apr/2011

Abstract:

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

Priority:

Inventor: SELIM ABDULHAFEZ A [US]; SHIMP LAWRENCE A [US]; WANG HSIU YING SHERRY [US]


Application No.: US20120276204A1  Published: 01/Nov/2012

Title: Bone Growth Compositions and Methods

Applicant/Assignee: NEUROPRO TECHNOLOGIES, INC

Application No.: 13/306830   Filing Date: 29/Nov/2011

Abstract:

The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. The invention is suitable for promoting non-anatomic or heterotopic bone growth between any bony surfaces where bone growth is desired but does not naturally occur.

Priority: US2006-422029 Applic. Date: 2006-06-02; US2003-460645 Applic. Date: 2003-06-11; US2002-282338 Applic. Date: 2002-10-28; US2002-388222P Applic. Date: 2002-06-13; US2002-394791P Applic. Date: 2002-07-10

Inventor: REMINGTON BENJAMIN J [US]; BEARSS DAVID J [US]; SHAHI KAVIAN [US]


Application No.: US20120277101A1  Published: 01/Nov/2012

Title: Composition Comprising a Pesticide and an Acetal Solvent

Applicant/Assignee: BASF SE

Application No.: 13/457789   Filing Date: 27/Apr/2012

Abstract:

The present invention relates to an agrochemical composition comprising a pesticide and a solvent of the formula (B) as described hereinbelow. The invention furthermore relates to a process for the preparation of the composition by bringing the pesticide and the solvent into contact

a use of the solvent of the formula (B) as a solvent for pesticides

methods for controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or on the plants to be protected from the respective pest, on the soil and/or on undesired plants and/or on the crop plants and/or on their environment

and on seed comprising the composition.

Priority: EP20110166304 Applic. Date: 2011-05-17; US201161480394P Applic. Date: 2011-04-29

Inventor: KLINGELHOEFER PAUL [DE]; SCHNABEL GERHARD [DE]; PELZER RALF [DE]; SPIEGLER WOLFGANG [DE]


Application No.: US20120277152A1  Published: 01/Nov/2012

Title: COMPRESSED HIGH DENSITY FIBROUS POLYMERS SUITABLE FOR IMPLANT

Applicant/Assignee:

Application No.: 13/418733   Filing Date: 13/Mar/2012

Abstract:

An embodiment of the present invention may be made by the following steps: providing a mixture comprising a plurality of fibers, a lubricant, and a suspension fluid, with the suspension fluid filling a void space between said fibers and subjecting said mixture to at least one compressive force. The compressive force causes the migration and alignment of said fibers

and may remove substantially all of the suspension fluid from said mixture. The mixture may further comprise a biologically active agent, or a reinforcing agent.

Priority: US2003-729146 Applic. Date: 2003-12-04

Inventor: RINGEISEN TIMOTHY A [US]; WATTENGEL W CHRISTIAN [US]


Application No.: US20120277321A1  Published: 01/Nov/2012

Title: METHOD FOR PREPARING A COMPOSITION COMPRISING A COMPOUND BASED ON VANILLIN AND ETHYL VANILLIN, RESULTING COMPOSITION AND USES THEREOF

Applicant/Assignee:

Application No.: 13/500747   Filing Date: 01/Oct/2010

Abstract:

A method for preparing a composition including a compound based on vanillin and ethyl vanillin is described. A resulting composition and uses thereof in many fields of application, in particular in human and animal food is also described. A method for preparing a composition including a compound based on vanillin and ethylvanillin in a vanillin/ethyl vanillin molar ratio of 2 is also described wherein the method includes: a step of melting a mixture of vanillin and ethyl vanillin, which are used in a molar ratio other than 2, with an excess of vanillin representing from 2% to 20% of the weight of the mixture

a step of solidifying same, by cooling to a temperature of less than or equal to 50 DEG C.+-1 DEG C.

and a step of recovering the resulting composition including the new compound.

Priority: FR20090004810 Applic. Date: 2009-10-08; WO2010EP64641 Applic. Date: 2010-10-01

Inventor: LE-THIESSE JEAN-CLAUDE [FR]; LAMIRI KILANI [FR]


Application No.: US20120282270A1  Published: 08/Nov/2012

Title: FORMULATION OF HUMAN ANTIBODIES FOR TREATING TNF-ALPHA ASSOCIATED DISORDERS

Applicant/Assignee: ABBOTT BIOTECHNOLOGY, LTD

Application No.: 13/471820   Filing Date: 15/May/2012

Abstract:

A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.

Priority: US2005-525292 Applic. Date: 2005-10-27; WO2003IB04502 Applic. Date: 2003-08-15; US2002-222140 Applic. Date: 2002-08-16

Inventor: KRAUSE HANS-JEURGEN [DE]; BAUST LISA [DE]; DICKES MICHAEL [DE]


Application No.: US20120282312A1  Published: 08/Nov/2012

Title: ACTIVE INGREDIENT DELIVERY SYSTEM

Applicant/Assignee: FIRMENICH SA

Application No.: 13/509901   Filing Date: 20/Dec/2010

Abstract:

A spray-chilled particulate delivery system that has a crystalline matrix structure and includes a volatile hydrophobic active ingredient and a carrier material of erythritol, mannitol and mixtures thereof 75% or more of the carrier material, relative to the total weight of the carrier material, is in crystalline form. The system is prepared by a process that includes the steps of forming a melt of the carrier material, incorporating a volatile hydrophobic active ingredient into the melt, forming a melt-mixture comprising an emulsion, dispersion or suspension of the volatile hydrophobic active ingredient in the melt, forming discrete particles of the melt mixture, and cooling the discrete particles.

Priority: EP20090180719 Applic. Date: 2009-12-24; US2009-288921P Applic. Date: 2009-12-22; WO2010IB55938 Applic. Date: 2010-12-20

Inventor: GREGSON CHRISTOPHER [US]; SILLICK MATTHEW [US]


Application No.: US20120282340A1  Published: 08/Nov/2012

Title: DRUG DELIVERY SYSTEM

Applicant/Assignee: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

Application No.: 13/130326   Filing Date: 13/Nov/2009

Abstract:

The present invention relates to drug delivery systems in the form of thin water-soluble films (wafers), which contain an Estrogen Receptor beta (ER-[beta]) selective agonist. The wafers of the present invention are suitable for treating, alleviating or preventing a physical condition in a female mammal caused by insufficient endogenous levels of estrogen.

Priority: EP20080105842 Applic. Date: 2008-11-21; EP20090075321 Applic. Date: 2009-07-17; WO2009EP08080 Applic. Date: 2009-11-13

Inventor: TEREBESI ILDIKO [DE]; FUNKE ADRIAN [DE]; DIEFENBACH KONSTANZE [CN]; SCHAEFERS MATTHIAS [DE]; GENERAL SASCHA [DE]


Application No.: US20120283233A1  Published: 08/Nov/2012

Title: CARRIER COMPOSITION

Applicant/Assignee:

Application No.: 13/501498   Filing Date: 04/Feb/2011

Abstract:

The present invention relates to a carrier composition comprising a phosphate compound of an electron transfer agent and a polar aprotic solvent. Biologically active compounds formulated with the carrier composition have been shown to have improved properties.

Priority: AU20100900463 Applic. Date: 2010-02-05; AU20100902463 Applic. Date: 2010-06-04; US2010-306115P Applic. Date: 2010-02-19; WO2011AU00122 Applic. Date: 2011-02-04

Inventor: GAVIN PAUL DAVID [AU]; EL-TAMIMY MAHMOUD [AU]; LIBINAKI ROKSAN [AU]; MOZAFARI MOHAMMAD REZA [AU]


Application No.: US20120283336A1  Published: 08/Nov/2012

Title: PREPARATION OF SHAPED METAL PARTICLES AND THEIR USES

Applicant/Assignee: BASF SE

Application No.: 13/259186   Filing Date: 17/Mar/2010

Abstract:

The instant invention relates to shaped transition metal particles, in particular in the form of a dispersion in an aqueous and/or organic medium, the manufacture thereof and their use as an infrared (IR) absorbing agent, an IR curing agent for coatings, an additive in conductive formulations, an antimicrobial agent or for sensoring organic and/or inorganic compounds. Further, the invention relates to dispersions comprising said shaped particles and an aqueous and/or organic medium, such as a thermoplastic or crosslinkable polymer, as well as to antimicrobial compositions and products.

Priority: EP20090156050 Applic. Date: 2009-03-24; WO2010EP53473 Applic. Date: 2010-03-17

Inventor: GRIGORENKO NIKOLAY A [CH]; MUEHLEBACH ANDREAS [CH]; MUEHLEBACH MICHAEL [CH]; MUEHLEBACH FLORIAN [CH]


Application No.: US20120288446A1  Published: 15/Nov/2012

Title: ORGANOPHOSPHOROUS & MULTIVALENT METAL COMPOUND COMPOSITIONS & METHODS

Applicant/Assignee:

Application No.: 13/469806   Filing Date: 11/May/2012

Abstract:

Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least multivalent metal compound, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments which exhibit bond strength upon curing with the possible usage as bone cement for bone filler applications.

Priority: US201161486064P Applic. Date: 2011-05-13

Inventor: GARIGAPATI VENKAT R [US]; TENHUISEN KEVOR S [US]


Application No.: US20120288462A1  Published: 15/Nov/2012

Title: COSMETIC PREPARATION AND USE THEREOF

Applicant/Assignee: SCHWAN-STABILO COSMETICS GMBH & CO. KG

Application No.: 13/318499   Filing Date: 02/Feb/2011

Abstract:

A cosmetic preparation characterized by excellent adhesion at the place of application, comprises at least one silsesquioxane wax.

Priority: DE201020001688U Applic. Date: 2010-02-02; WO2011EP00474 Applic. Date: 2011-02-02

Inventor: LEBOK SIMONA [DE]; HELL SIGRID [DE]; SKULTETY MARIKA [DE]


Application No.: US20120288540A1  Published: 15/Nov/2012

Title: NIOSOMES, FREEZE-DRIED POWDER THEREOF AND THEIR USE IN TREATMENT

Applicant/Assignee: UNIVERSITA DEGLI STUDI "MAGNA GRAECIA" CATANZARO, UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA"

Application No.: 13/519200   Filing Date: 05/Jan/2011

Abstract:

The present invention relates to a vesicular structure formed of a mixture of a non-ionic surfactant and cholesterol, characterised in that it is freeze-dried in the presence of a cryoprotectant, to a method for the preparation and to the use thereof.

Priority: IT2010RM00002 Applic. Date: 2010-01-07; WO2011IB50041 Applic. Date: 2011-01-05

Inventor: CARAFA MARIA [IT]; ALHAIQUE FRANCO [IT]; MARIANECCI CARLOTTA [IT]; PAOLINO DONATELLA [IT]; FRESTA MASSIMO [IT]


Application No.: US20120288561A1  Published: 15/Nov/2012

Title: DELAYED-RELEASE FORMULATION FOR REDUCING THE FREQUENCY OF URINATION AND METHOD OF USE THEREOF

Applicant/Assignee: WELLESLEY PHARMACEUTICALS, LLC

Application No.: 13/560665   Filing Date: 27/Jul/2012

Abstract:

Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent.

Priority: US201213487343 Applic. Date: 2012-06-04; US201213423949 Applic. Date: 2012-03-19; US201213343349 Applic. Date: 2012-01-04; US2010-956634 Applic. Date: 2010-11-30; US2010-362374P Applic. Date: 2010-07-08

Inventor: DILL DAVID A [US]


Application No.: US20120288564A1  Published: 15/Nov/2012

Title: Interpenetrating polymer network comprising fibrin

Applicant/Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Application No.: 13/068481   Filing Date: 11/May/2011

Abstract:

There is provided a method of forming a hydrogel, the method comprising: providing a mixture of a polymer comprising a cross-linkable pendant phenolic group, peroxidase, H2O2, fibrinogen, and thrombin, at concentration sufficient to enzymatically cross-link the polymer and to cleave the fibrinogen to yield fibrin

and allowing the mixture to form a hydrogel. There is also provided a hydrogel comprising a cross-linked network of a polymer interpenetrated by fibrin fibers, the polymer cross-linked by oxidative coupling between phenolic groups pendant on the polymer.

Priority:

Inventor: KURISAWA MOTOICHI [SG]; LEE FAN [SG]


Application No.: US20120288565A1  Published: 15/Nov/2012

Title: TAMPER-RESISTANT ORAL OPIOID AGONIST FORMULATIONS

Applicant/Assignee: PURDUE PHARMA L.P

Application No.: 13/544333   Filing Date: 09/Jul/2012

Abstract:

Disclosed is an oral dosage form comprising: (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is not released when the dosage form is administered orally intact.

Priority: US2010-909614 Applic. Date: 2010-10-21; US2003-689866 Applic. Date: 2003-10-21; US2001-781081 Applic. Date: 2001-02-08; US2000-181369P Applic. Date: 2000-02-08

Inventor: OSHLACK BENJAMIN [US]; WRIGHT CURTIS [US]; HADDOX J DAVID [US]


Application No.: US20120289402A1  Published: 15/Nov/2012

Title: ADJUVANT COMPOSITION AND AGROCHEMICAL FORMULATION CONTAINING SAME

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS INC

Application No.: 13/103630   Filing Date: 09/May/2011

Abstract:

An adjuvant composition is provided which comprises: (a) at least one water-soluble electrolyte

(b) at least one electrolyte-tolerant surfactant

(c) antifoam component which is at least one mixture selected from the group consisting of (1) at least one branched silicone resin (i), at least one silicone fluid (ii), at least one particulate metal oxide (iii) and, optionally, at least one catalyst (iv) for catalyzing the condensation of siloxy groups, (2) the equilibration reaction product of mixture (1), and (3) mixture (1) in which at least a portion of particulate metal oxide (iii) is pre-hydrophobized

(d) optionally, at least one additional bioinert material

and, (e) water.

Priority:

Inventor: BROWN WILLIAM L [US]; KOCZO KALMAN [US]; POLICELLO GEORGE A [US]


Application No.: US20120289470A1  Published: 15/Nov/2012

Title: TRANSMUCOSAL ADMINISTRATION OF DRUG COMPOSITIONS FOR TREATING AND PREVENTING DISORDERS IN ANIMALS

Applicant/Assignee: NOVADEL PHARMA, INC, VELCERA PHARMACEUTICALS, INC

Application No.: 13/327028   Filing Date: 15/Dec/2011

Abstract:

The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, clemastine, diphenhydramine, digoxin, levothyroxine, cyclosporine, ondansetron, lysine, zolpidem, propofol, nitenpyram, ivermectin, milbemycin, and pharmaceutically acceptable salts, solvates and esters thereof. In another embodiment, the invention includes methods of treating or preventing a condition in an animal comprising transmucosally administering a composition comprising a therapeutically or prophylactically effective amount of an active agent and a pharmaceutically acceptable carrier.

Priority: US2006-356451 Applic. Date: 2006-02-17; US2005-664183P Applic. Date: 2005-03-23; US2005-653964P Applic. Date: 2005-02-17; US2005-661920P Applic. Date: 2005-03-16; US2005-664939P Applic. Date: 2005-03-25; US2005-665525P Applic. Date: 2005-03-28; US2005-664181P Applic. Date: 2005-03-23; US2005-664938P Applic. Date: 2005-03-25; US2005-669888P Applic. Date: 2005-04-11; US2005-670651P Applic. Date: 2005-04-13; US2005-693942P Applic. Date: 2005-06-27

Inventor: HEIT MARK C [US]; BENITZ ANTONIO M [US]; STEADMAN DENNIS F [US]; PETRICK DAVID M [US]


Application No.: US20120289609A1  Published: 15/Nov/2012

Title: METHODS FOR THE FORMATION OF HYDROGELS USING THIOSULFONATE COMPOSITIONS AND USES THEREOF

Applicant/Assignee: NEKTAR THERAPEUTICS

Application No.: 13/554292   Filing Date: 20/Jul/2012

Abstract:

The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.

Priority: US201113325936 Applic. Date: 2011-12-14; US2009-547369 Applic. Date: 2009-08-25; US2007-904985 Applic. Date: 2007-09-27; US2003-751010 Applic. Date: 2003-12-31; US2002-437252P Applic. Date: 2002-12-31

Inventor: FANG ZHIHAO [US]; BENTLEY MICHAEL D [US]


Application No.: US20120294903A1  Published: 22/Nov/2012

Title: METHODS AND SYSTEMS OF MAKING NANOSTRUCTURES

Applicant/Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Application No.: 13/457609   Filing Date: 27/Apr/2012

Abstract:

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.

Priority: US201161480500P Applic. Date: 2011-04-29

Inventor: GUO PENG [US]; MARTIN CHARLES R [US]; ZHAO YAPING [CN]; ZARE RICHARD N [US]


Application No.: US20120294912A1  Published: 22/Nov/2012

Title: O/W EMULSION COSMETIC

Applicant/Assignee: KAO CORPORATION

Application No.: 13/480581   Filing Date: 25/May/2012

Abstract:

A cosmetic composition in the form of an O/W emulsion includes: (A) 1 to 20% by weight of a plate-like powder that has been surface-treated with an alkylalkoxysilane, (B) 0.1 to 10% by weight of an oil that is solid at a temperature of 25 DEG C., (C) 0.3 to 50% by weight of an oil selected from the group consisting of a hydrocarbon oil, an ester oil, and an ether oil, each having a viscosity of 500,000 mPas or less at a temperature of 25 DEG C., (D) 0.1 to 20% by weight of a nonionic surfactant having an HLB value of 8 or less, (E) 0.05 to 10% by weight of a water-soluble polymer having a hydrocarbon group with a carbon number of 8 to 30 and an anionic group in a molecule thereof, and (F) water.

Priority: JP20090267497 Applic. Date: 2009-11-25; WO2010JP71047 Applic. Date: 2010-11-25

Inventor: FUKUI TAKASHI [JP]; KAWATA TAKASHI [JP]


Application No.: US20120294923A1  Published: 22/Nov/2012

Title: ANTIVIRAL AGENT AND ANTIVIRAL AGENT FUNCTIONAL PRODUCT USING THE SAME

Applicant/Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED

Application No.: 13/512779   Filing Date: 30/Nov/2010

Abstract:

An object of the present invention is to provide an antiviral agent which exhibits high antiviral activity even under irradiation with visible light and is capable of detoxifying a virus. The antiviral agent according to the present application is composed of a dispersion containing noble metals and photocatalyst particles as supported by the noble metals, the dispersion containing 0.01 part by mass to 1 part by mass of noble metal atoms based on 100 parts by mass of photocatalyst particles.

Priority: JP20090273227 Applic. Date: 2009-12-01; WO2010JP71348 Applic. Date: 2010-11-30

Inventor: SUYASU YUKO [JP]; SAKATANI YOSHIAKI [JP]; TAKEHARA KAZUAKI [JP]


Application No.: US20120294924A1  Published: 22/Nov/2012

Title: Peptide-Lipid Conjugates And Uses Thereof

Applicant/Assignee:

Application No.: 13/454211   Filing Date: 24/Apr/2012

Abstract:

Disclosed are peptide-lipid conjugates that bind lipopolysaccharide. Also disclosed are methods of making and using the peptide-lipid conjugates.

Priority: US201161480596P Applic. Date: 2011-04-29

Inventor: TICE THOMAS [US]; WOEHR TORSTEN [US]


Application No.: US20120294926A1  Published: 22/Nov/2012

Title: TWO OR MORE VOLATILE SOLVENT-CONTAINING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS

Applicant/Assignee:

Application No.: 13/566273   Filing Date: 03/Aug/2012

Abstract:

The present invention is drawn to adhesive formulations and methods of drug delivery. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least two volatile solvents, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

Priority: US2006-640117 Applic. Date: 2006-12-14; US2005-146917 Applic. Date: 2005-06-06; US2005-750637P Applic. Date: 2005-12-14; US2004-577536P Applic. Date: 2004-06-07

Inventor: ZHANG JIE [US]; WARNER KEVIN S [US]; SHARMA SANJAY [US]


Application No.: US20120294928A1  Published: 22/Nov/2012

Title: METHOD OF TREATING SCARS AND B-CATENIN-MEDIATED DISORDERS USING NEFOPAM COMPOUNDS

Applicant/Assignee:

Application No.: 13/516016   Filing Date: 15/Dec/2010

Abstract:

Methods of treating disorders mediated by [beta]-catenin comprising administration of Nefopam compounds are provided In particular, the treatment of disorders arising from excessive or undesired expression of [beta]-catenin is contemplated Said compounds include Nefopam, analogues thereof, prodaigs thereof, and salts and solvates of Nefopam The [beta]-catenin mediated disorders are preferably selected from the group consisting of fibroproliferative disorders (such as scars, aggressive fibramtoses, and fibroses) and cancer (such as colon cancer, melanoma, liver cancer, ovarian cancer, endometrial cancer, medullobalstoma pilomatricomas, and prostate cancer)

Priority: US2009-286633P Applic. Date: 2009-12-15; WO2010CA02014 Applic. Date: 2010-12-15

Inventor: ALMAN BENJAMIN A [CA]; POON RAYMOND [CA]; HONG HELEN [CA]


Application No.: US20120294934A1  Published: 22/Nov/2012

Title: TRANSDERMAL COMPOSITIONS FOR ANTICHOLINERGIC AGENTS

Applicant/Assignee: ANTARES PHARMA IPL AG

Application No.: 13/566900   Filing Date: 03/Aug/2012

Abstract:

The present invention relates generally to compositions or formulations for transdermal or transmucosal administration of anti-cholinergic agents such as oxybutynin. The invention utilizes a novel delivery vehicle and is a substantially malodorous-free and irritation free transdermal formulation which is substantially free of long chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters. A method is disclosed for administering such formulations to a person in need thereof while reducing the incidences of peak concentrations of drug and undesirable side effects associated with oral anti-cholinergics.

Priority: WO2000EP07533 Applic. Date: 2000-08-03; US2009-614216 Applic. Date: 2009-11-06; US2004-798111 Applic. Date: 2004-03-10; US2007-755923 Applic. Date: 2007-05-31; US2006-371042 Applic. Date: 2006-03-07; WO2004EP11175 Applic. Date: 2004-10-06; US2006-634005 Applic. Date: 2006-12-04; US2003-343570 Applic. Date: 2003-05-19; WO2001EP09007 Applic. Date: 2001-08-03; US2003-510613P Applic. Date: 2003-10-10; US2003-453604P Applic. Date: 2003-03-11

Inventor: CARRARA DARIO NORBERTO R [CH]; GRENIER ARNAUD [FR]


Application No.: US20120294938A1  Published: 22/Nov/2012

Title: PHARMACEUTICAL PREPARATION FOR ORAL ADMINISTRATION WITH CONTROLLED ACTIVE INGREDIENT RELEASE IN THE SMALL INTESTINE AND METHOD FOR ITS PRODUCTION

Applicant/Assignee: DR. R. PFLEFGER CHEMISCHE FABRIK GMBH

Application No.: 13/525029   Filing Date: 15/Jun/2012

Abstract:

Any pharmaceutical preparation for oral administration with controlled release of active ingredient in the small bowel, on the basis of active ingredient carriers provided with at least one active ingredient which are provided with an inner layer to control the release of active ingredient and with a gastro-resistant coating layer disposed thereon, which is characterized in that the inner layer is formed from at least two diffusion layers whose permeability for the diffusing active ingredient decreases from the inside to the outside, and a method for the production thereof, are described.

Priority: EP20060014244 Applic. Date: 2006-07-10; US2009-309198 Applic. Date: 2009-01-23; WO2007EP05970 Applic. Date: 2007-07-05

Inventor: JUNG GERD [DE]; SCHAUPP ALBERT [DE]


Application No.: US20120294943A1  Published: 22/Nov/2012

Title: EXTENDED-RELEASE FORMULATION FOR REDUCING THE FREQUENCY OF URINATION AND METHOD OF USE THEREOF

Applicant/Assignee: WELLESLEY PHARMACEUTICALS, LLC

Application No.: 13/560607   Filing Date: 27/Jul/2012

Abstract:

Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent formulated for extended-release.

Priority: US201213487348 Applic. Date: 2012-06-04; US201213424000 Applic. Date: 2012-03-19; US201213343332 Applic. Date: 2012-01-04; US2010-956634 Applic. Date: 2010-11-30; US2010-362374P Applic. Date: 2010-07-08

Inventor: DILL DAVID A [US]


Application No.: US20120295986A1  Published: 22/Nov/2012

Title: CALCIUM SEQUESTERING COMPOSITION

Applicant/Assignee:

Application No.: 13/452578   Filing Date: 20/Apr/2012

Abstract:

This invention relates to compositions which are capable of sequestering calcium ions and are derived in part from renewable carbohydrate feedstocks. The calcium sequestering compositions are mixtures containing one or more hydroxycarboxylic acid salts and one or more aluminum salts.

Priority: US201161477786P Applic. Date: 2011-04-21

Inventor: SMITH TYLER N [US]; SHIRLEY RICHARD [US]


Application No.: US20120301526A1  Published: 29/Nov/2012

Title: Nanostructured titanium oxide material and its synthesis procedure

Applicant/Assignee: INSTITUTO MEXICANO DEL PETROLEO

Application No.: 13/527245   Filing Date: 19/Jun/2012

Abstract:

Nanomaterials of the JT phase of the titanium oxide TiO2-x, where 0!<=x!<=1 having as a building block a crystalline structure with an orthorhombic symmetry and described by at least one of the space groups 59 Pmmn, 63 Amma, 71 Immm or 63 Bmmb. The nanomaterials are in the form of nanofibers, nanowires, nanorods, nanoscrolls and/or nanotubes and are obtained from a hydrogen titanate and/or a mixed sodium and hydrogen titanate precursor compound that is isostructural to the JT crystalline structure. The titanates are the hydrogenated, the protonated, the hydrated and/or the alkalinized phases of the JT crystalline phase that are obtained from titanium compounds such as titanium oxide with an anatase crystalline structure, amorphous titanium oxide, and titanium oxide with a rutile crystalline structure, and/or directly from the rutile mineral and/or from ilmenite.

Priority: MX2004PA04265 Applic. Date: 2004-05-04; US2010-848392 Applic. Date: 2010-08-02; US2009-623993 Applic. Date: 2009-11-23; US2005-121178 Applic. Date: 2005-05-04; WO2004MX00035 Applic. Date: 2004-05-26; WO2003MX00081 Applic. Date: 2003-10-10; US2005-646973P Applic. Date: 2005-01-27

Inventor: TOLEDO ANTONIO JOSE ANTONIO [MX]; ANGELES CHAVEZ CARLOS [MX]; CORTES JACOME MARIA ANTONIA [MX]; ALVAREZ RAMIREZ FERNANDO [MX]; RUIZ MORALES YOSADARA [MX]; FERRAT TORRES GERARDO [MX]; FLORES ORTIZ LUIS FRANCISCO [MX]; LOPEZ SALINAS ESTEBAN [MX]; LOZADA Y CASSOU MARCELO [MX]


Application No.: US20120302445A1  Published: 29/Nov/2012

Title: PROCESS FOR RECYCLING POLYMER FINES

Applicant/Assignee:

Application No.: 13/574945   Filing Date: 18/Jan/2011

Abstract:

The present invention relates to a process for producing a water-absorbing polymer structure based on acid group-containing monomers, comprising the process steps of: i) providing a monomer solution comprising the optionally partly neutralized, acid group-containing monomer

ii) mixing the monomer solution with fines which consist at least to an extent of 90% by weight, based on the total weight of the fines, of particles having a particle size of less than 850 [mu]m, to obtain a monomer solution mixed with fines

wherein the mixing in process step ii) is effected in a mixer in which a first stream of the fines and at least one further stream of the monomer solution are passed from different directions simultaneously to a rotating mixing tool.

Priority: DE201010008163 Applic. Date: 2010-02-16; WO2011EP50570 Applic. Date: 2011-01-18

Inventor: RUDOLPH HENRY [DE]; HOEFGES THOMAS [DE]; VAN STIPHOUDT MANFRED [DE]; HARREN JOERG [DE]; WATTEBLED LAURENT [DE]; FURNO FRANCK [DE]; SOPPE FRANK [DE]


Application No.: US20120302634A1  Published: 29/Nov/2012

Title: SKIN PROTECTION COMPOSITIONS, IN PARTICULAR CREAM TO PROTECT AGAINST COLD

Applicant/Assignee: EVONIK STOCKHAUSEN GMBH

Application No.: 13/494351   Filing Date: 12/Jun/2012

Abstract:

The invention relates to a silicone-free skin protection composition, in particular a composition to protect against cold, containing the components a.) at least one oil with a pour point in accordance with DIN ISO 30 16 of !<=-10 DEG C., b.) at least one polyol c.) at least one emulsifier d.) optionally at least one wax, where the viscosity difference in the temperature interval from +4 DEG C. to +50 DEG C. of highest and lowest viscosity of the skin protection composition has a value in the range from 0 to !<=20 000 mPas.

Priority: DE200610053360 Applic. Date: 2006-11-10; US2009-514326 Applic. Date: 2009-05-11; WO2007EP09726 Applic. Date: 2007-11-09

Inventor: VEEGER MARCEL [DE]; ALLEF PETRA [DE]


Application No.: US20120302816A1  Published: 29/Nov/2012

Title: THERAPEUTIC COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF ACTIVE AGENTS

Applicant/Assignee: WILLIAM MARSH RICE UNIVERSITY

Application No.: 13/504716   Filing Date: 27/Oct/2010

Abstract:

The present invention pertains to therapeutic compositions that comprise: (1) a nanovector, (2) an active agent

and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention.

Priority: US2009-255309P Applic. Date: 2009-10-27; WO2010US54321 Applic. Date: 2010-10-27

Inventor: TOUR JAMES M [US]; BERLIN JACOB [US]; PHAM TAM [US]; MYERS JEFFREY N [US]; SANO DAISUKE [JP]


Application No.: US20120308486A1  Published: 06/Dec/2012

Title: Fragrance and/or flavoring compositions containing dioxolanes

Applicant/Assignee: SYMRISE AG

Application No.: 13/473053   Filing Date: 16/May/2012

Abstract:

The present invention primarily relates to the use of dioxolanes of the following Formula (I) as fragrance and/or flavoring substances, certain perfume and/or flavoring compositions comprising these dioxolanes and corresponding perfumed and/or flavored items. The present invention also relates to a method for producing the dioxolanes of Formula (I) and certain new dioxolanes according to Formula (I).

Priority: EP20110166440 Applic. Date: 2011-05-17; US201161486998P Applic. Date: 2011-05-17

Inventor: SINGER EMILIE [DE]; HOELSCHER BERND [DE]


Application No.: US20120308487A1  Published: 06/Dec/2012

Title: Carnallite Preparation and Uses Thereof in Edible Applications

Applicant/Assignee: ICL PERFORMANCE PRODUCTS LP

Application No.: 13/484914   Filing Date: 31/May/2012

Abstract:

The present invention relates to a Carnallite salt preparation useful in edible products, such as a food, beverage, dietary supplement, oral care, nutraceutical pet food, animal feed, pharmaceutical and other edible products. The Carnallite salt preparation of the invention is without high levels of sodium chloride and notably low in bromide. The Carnallite salt preparation may be a food grade product with dietary acceptable bromide levels. The present invention further relates to edible products comprising the Carnallite salt preparation, such as reduced sodium food products.

Priority: US201161493328P Applic. Date: 2011-06-03

Inventor: STACHIW NANCY [US]; HEIDOLPH BARBARA BUFE [US]; EFFENBERGER REINHARD [IL]; STOVER FREDERICK S [US]; ZHOU LIRONG [US]


Application No.: US20120308492A1  Published: 06/Dec/2012

Title: FOAMABLE OIL-WATER EMULSION

Applicant/Assignee: EVONIK STOCKHAUSEN GMBH

Application No.: 13/380064   Filing Date: 30/Jun/2010

Abstract:

The present invention relates to foamable oil-in-water emulsions containing: A) one or more emulsifiers, at least one of which is a non-ionic emulsifier, B) one or more cotensides, C) one or more oils, D) optionally, one or more polar solubilizers, E) optionally, auxiliary and additive substances, F) one or more surfactants, G) water, H) optionally, water-soluble substances, provided that the water content of the emulsion is >=70% by weight and the concentration of surfactant(s) F) is from 0.01 to less than 10% by weight, each based on the entire emulsion. The invention further relates to a method for producing the oil-water emulsions according to the invention, to foams obtained from these oil-water emulsions, to a method for producing the foams, and to the application of the oil-water emulsions according to the invention and to the foams produced therefrom.

Priority: DE200910028156 Applic. Date: 2009-07-31; WO2010EP59246 Applic. Date: 2010-06-30

Inventor: ALLEF PETRA [DE]; VEEGER MARCEL [DE]; KLOTZBACH VOLKER [DE]


Application No.: US20120308502A1  Published: 06/Dec/2012

Title: Personal Care Composition Comprising a Surfactant-Rich Gel Network

Applicant/Assignee:

Application No.: 13/152848   Filing Date: 03/Jun/2011

Abstract:

The present application relates to a process for preparing a personal care composition by combining a fatty amphiphile above its melt temperature and a surfactant in a weight ratio from 0.1:1 to 0.99:1 to form a gel network premix contacting the gel network premix with a shearing device, cooling the gel network premix to a temperature below the melt temperature of the fatty amphiphile and adding the cooled premix to personal care components to form the personal care composition.

Priority:

Inventor: WISE GEOFFREY MARC [US]; WOOD RANDALL LEE [US]; CHU LONG VAN [US]


Application No.: US20120309720A1  Published: 06/Dec/2012

Title: COMPOSITIONS AND METHODS FOR TREATMENT OF GLAUCOMA

Applicant/Assignee: ALPHA SYNERGY DEVELOPMENT INC

Application No.: 13/585602   Filing Date: 14/Aug/2012

Abstract:

The invention provides [alpha]-2 adrenergic receptor agonist compositions and methods for treating glaucoma and other intraocular conditions. The preferred [alpha]-2 agonist used in the inventive compositions and methods is dexmedetomidine.

Priority: US201213365138 Applic. Date: 2012-02-02; US2011-931632 Applic. Date: 2011-02-03

Inventor: HORN GERALD [US]


Application No.: US20120309763A1  Published: 06/Dec/2012

Title: ANTIFUNGAL COMPOSITION INTENDED TO BE APPLIED TO A PERFORATED NAIL

Applicant/Assignee: GALDERMA PHARMA S.A

Application No.: 13/516962   Filing Date: 17/Dec/2010

Abstract:

A pharmaceutical composition intended to be applied to a perforated nail is described. In particular, a composition is descirbed that includes an antifungal agent that is in the form of an acid salt, advantageously a hydrochloride

and a solvent system

and advantageously a cationic or positively charged amphoteric surfactant. The described composition can have a viscosity of less than 500 cPs.

Priority: FR20090059186 Applic. Date: 2009-12-18; WO2010EP70086 Applic. Date: 2010-12-17

Inventor: MALLARD CLAIRE [FR]; WILLCOX NATHALIE [FR]


Application No.: US20120309836A1  Published: 06/Dec/2012

Title: METHODS AND COMPOSITIONS FOR ADMINISTRATION OF TRPV1 AGONISTS

Applicant/Assignee: NEUROGESX, INC

Application No.: 13/585692   Filing Date: 14/Aug/2012

Abstract:

Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

Priority: US201113083306 Applic. Date: 2011-04-08; US2004-823426 Applic. Date: 2004-04-12; US2003-499062P Applic. Date: 2003-08-29; US2003-462040P Applic. Date: 2003-04-10; US2003-462457P Applic. Date: 2003-04-10

Inventor: MUHAMMAD NAWEED [US]; JAMIESON GENE C [US]; BLEY KEITH R [US]; CHANDA SANJAY [US]


Application No.: US20120309849A1  Published: 06/Dec/2012

Title: USE OF GLYCERIN SHORT-CHAIN ALIPHATIC ETHER COMPOUNDS

Applicant/Assignee: ECOLAB USA INC

Application No.: 13/484694   Filing Date: 31/May/2012

Abstract:

A solvent or composition that includes a glycerin short-chain aliphatic ether may be used in a method for coupling, coalescing or adjusting viscosity of a composition.

Priority: US201161492684P Applic. Date: 2011-06-02

Inventor: GRIESE GREGORY G [US]; LEVITT MARK D [US]; SILVERNAIL CARTER M [US]


Application No.: US20120315301A1  Published: 13/Dec/2012

Title: Preparation of vesicle-type carbon nanotubes

Applicant/Assignee: LORESTAN UNIVERSITY

Application No.: 13/067546   Filing Date: 08/Jun/2011

Abstract:

A method to prepare new morphologies, especially vesicle-type, of carbon nanotubes (CNT) by supramolecular interactions between them and dendritic or linear-dendritic polymers and copolymers. Due to their water solubility, high functionality and unique properties, the prepared hybrid nanomaterials have excellent applicability in different fields especially in nanomedicine in comparison with usual CNTs.

Priority:

Inventor: ADELI MOHSEN [IR]; BAVADI MASOUMEH [IR]; ASHIRI MASOUMEH [IR]; HAMID MASOUMEH [IR]; BEYRANVAND SIAMAK [IR]


Application No.: US20120315315A1  Published: 13/Dec/2012

Title: Foam Formulations Containing at Least One Triterpenoid

Applicant/Assignee: NEUBOURG SKIN CARE GMBH & CO., KG

Application No.: 13/580294   Filing Date: 02/Mar/2011

Abstract:

The invention relates to a foam formulation comprising an emulsion, comprising an oil phase and an aqueous phase, wherein the emulsion comprises at least one triterpenoid. Further the invention relates to anemulsion comprising an oil phase and an aqueous phase, wherein the emulsion comprises at least one triterpenoid selected from the group consisting of betulin, betulinic acid, lupeol, erythrodiol, oleanolic acid, (C1-C6) alkyl esters of the aforementioned acids, or mixtures thereof, and wherein the oil phase comprises at least one membrane-forming substance forming a lamellar arranged membrane in the emulsion.

Priority: EP20100155214 Applic. Date: 2010-03-02; WO2011EP53131 Applic. Date: 2011-03-02

Inventor: NEUBOURG THOMAS [DE]


Application No.: US20120315333A1  Published: 13/Dec/2012

Title: DIRECT INKJET FABRICATION OF DRUG DELIVERY DEVICES

Applicant/Assignee: XEROX CORPORATION

Application No.: 13/156503   Filing Date: 09/Jun/2011

Abstract:

In some aspects of the present application, a method of forming one or more layers of at least a portion of a drug delivery device (DDD) is described. The method can include providing a substrate

providing one or more DDD components that are dissolved or dispersed in one or more pharmaceutically compatible phase change inks

ejecting, by one or more nozzles, a first portion of the one or more pharmaceutically compatible phase change inks to form a first layer on the substrate

and ejecting, by the one or more nozzles, a second portion of the pharmaceutically compatible phase change inks to form a second layer over the first layer.

Priority:

Inventor: ZHOU JING [US]; CHANG SHU [US]


Application No.: US20120317880A1  Published: 20/Dec/2012

Title: SEED-BORNE, SOIL AMENDMENT METHOD AND COMPOSITION

Applicant/Assignee:

Application No.: 13/598135   Filing Date: 29/Aug/2012

Abstract:

A material for assisting in at least one of germination, protection, hydration, and thriving of seeds and the plants originating therefrom treats a seed with a tackifier or binder, such as corn syrup or the like, which secures a layer of hydrating polymer particles thereto. Nutrients, protectants, and the like may be absorbed in the polymer before or after coating of a seed thereby. Weighting materials, extenders, flowing agents, and the like may assist in the functioning or handling of the coated seeds.

Priority: US2010-913662 Applic. Date: 2010-10-27; US201213484482 Applic. Date: 2012-05-31; US2009-565452 Applic. Date: 2009-09-23; US2010-789177 Applic. Date: 2010-05-27; US2008-324608 Applic. Date: 2008-11-26; US201161531042P Applic. Date: 2011-09-05; US2008-099852P Applic. Date: 2008-09-24; US2007-012912P Applic. Date: 2007-12-11

Inventor: HENDRICKSON CALDER [US]; NAFF TODD [US]


Application No.: US20120321572A1  Published: 20/Dec/2012

Title: NOVEL SYNERGISTIC PRESERVATIVE SYSTEM

Applicant/Assignee:

Application No.: 13/397380   Filing Date: 15/Feb/2012

Abstract:

A novel three-component synergistic preservative system has zinc oxide, a phenoxyethanol component, and caprylyl glycol. The preservative system provides sufficient preservative activity without the use of other preservatives such as parabens. It provides broad spectrum activity against yeast and molds, and remains effective long term.

Priority: US201161443040P Applic. Date: 2011-02-15

Inventor: SPAULDING LAURA A [US]; FONTAURIA ALISSA R [US]; LA IACONNA VINCENT R [US]


Application No.: US20120321578A1  Published: 20/Dec/2012

Title: SOLID WATER-IN-OIL EMULSION COMPRISING A VOLATILE HYDROCARBON SOLVENT, A POLYGLYCEROLATED SURFACTANT AND A POLAR WAX

Applicant/Assignee: L'OREAL

Application No.: 13/515536   Filing Date: 14/Dec/2010

Abstract:

The invention relates to a solid water-in-oil emulsion comprising an aqueous phase emulsified in a fatty phase, comprising: one or more volatile linear alkane(s), especially C7-C14 alkane(s), a non-silicone polyglycerolated surfactant and a polar wax, especially a natural or natural-origin polar wax.

Priority: FR20090059180 Applic. Date: 2009-12-18; US2009-290942P Applic. Date: 2009-12-30; WO2010EP69618 Applic. Date: 2010-12-14

Inventor: LEURIDAN MAITENA [FR]; THEMENS AGNES [FR]; DUMOUSSEAUX CHRISTOPHE [FR]; DIQUE-MOUTON VALERIE [FR]


Application No.: US20120321596A1  Published: 20/Dec/2012

Title: KIT FOR ADHERING BIOLOGICAL HARD TISSUES

Applicant/Assignee: JUNSEI EDUCATIONAL INSTITUTION, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

Application No.: 13/580573   Filing Date: 22/Feb/2011

Abstract:

A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region.

Priority: JP20100036350 Applic. Date: 2010-02-22; WO2011JP53838 Applic. Date: 2011-02-22

Inventor: YOSHIDA YASUHIRO [JP]; TANAKA MASATO [JP]; SUZUKI KAZUOMI [JP]; OZAKI TOSHIFUMI [JP]; TAKAHATA TOMOHIRO [JP]; IRIE MASAO [JP]; NAKAMURA MARIKO [JP]; KAWASHIMA MITSUNOBU [JP]; NOJIRI YAMATO [JP]; OKADA KOICHI [JP]; NAGAO MASAHIRO [JP]


Application No.: US20120321604A1  Published: 20/Dec/2012

Title: CARRIER COMPRISING NON-NEUTRALISED TOCOPHERYL PHOSPHATE

Applicant/Assignee:

Application No.: 13/577124   Filing Date: 04/Feb/2011

Abstract:

The present invention relates to a carrier for the delivery of a nutraceutical or cosmeceutical active comprising non-neutralised tocopheryl phosphate and a hydrophobic vehicle. The present invention also relates to a formulation comprising the carrier and a nutraceutical or cosmeceutical active.

Priority: AU20100900463 Applic. Date: 2010-02-05; WO2011AU00112 Applic. Date: 2011-02-04

Inventor: LIBINAKI ROKSAN [AU]


Application No.: US20120321713A1  Published: 20/Dec/2012

Title: GASTRIC RETENTIVE EXTENDED-RELEASE DOSAGE FORMS COMPRISING COMBINATIONS OF A NON-OPIOID ANALGESIC AND AN OPIOID ANALGESIC

Applicant/Assignee: DEPOMED, INC

Application No.: 13/529960   Filing Date: 21/Jun/2012

Abstract:

Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (GI) of a mammal for an extended period of time.

Priority: US2009-644444 Applic. Date: 2009-12-22; US2009-402477 Applic. Date: 2009-03-11; US2008-035696P Applic. Date: 2008-03-11

Inventor: HAN CHIEN-HSUAN [US]; HOU SUI YUEN EDDIE [US]; REID MONICA L [US]


Application No.: US20120328538A1  Published: 27/Dec/2012

Title: Glycerine Based Jelly Compositions

Applicant/Assignee:

Application No.: 13/515205   Filing Date: 09/Dec/2010

Abstract:

The present disclosure describes a replacement for petroleum jelly as a base for products which is suitable for most any application for which petroleum jelly can be used. The jelly is a glycerine based jelly composition comprising

vegetable derived glycerine and an emulsifier, wherein the emulsifier can be any known and/or commercially available glucoside containing emulsifier. Other suitable emulsifiers together with glycerine and essential or vegetable based oils with or without inorganic fillers may also be added to the jelly to impart fragrance, color, UVA and UVB sun protection factor(s), immuno-enhancing aromatherapeutics, as well as free radical scavenging constituents. In addition, temperature stabilizers and stiffening agents such as waxes and other inorganic fillers including silica and clays may also be added during manufacture as required. The glycerine is preferably present in the range of 50-95%. Other ingredients which may be added include vitamins and provitamins, carotenoids, as well as aloe vera gel or juice.

Priority: US2009-285298P Applic. Date: 2009-12-10; US2010-345383P Applic. Date: 2010-05-17; WO2010US59634 Applic. Date: 2010-12-09

Inventor: GRUNE GUERRY L [US]; WINGFIELD WILLIAM [US]


Application No.: US20120328664A1  Published: 27/Dec/2012

Title: LIQUID FORMULATIONS

Applicant/Assignee:

Application No.: 13/606118   Filing Date: 07/Sep/2012

Abstract:

Disclosed is a concentrate for dilution comprising a S1P receptor agonist or a pharmaceutically acceptable salt thereof, propylene glycol and optionally glycerin. This formulation is adapted for patients in a difficult condition to swallow.

Priority: US2008-997909 Applic. Date: 2008-02-05; WO2006US30836 Applic. Date: 2006-08-08; US2005-706820P Applic. Date: 2005-08-09

Inventor: GEORGOUSIS VIVIAN [US]; TONG WEI-QIN [US]


Application No.: US20120328694A1  Published: 27/Dec/2012

Title: THERAPEUTIC AGENT FOR FIBROID LUNG

Applicant/Assignee: NITTI DENKO CORPORATION

Application No.: 13/585736   Filing Date: 14/Aug/2012

Abstract:

Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid

a therapeutic agent for fibroid lung, which utilized the carrier

and a preparation kit of the therapeutic agent.

Priority: JP20080068227 Applic. Date: 2008-03-17; US2010-933075 Applic. Date: 2010-12-10; WO2009JP01148 Applic. Date: 2009-03-16

Inventor: NIITSU YOSHIRO [JP]; TAKIMOTO RISHU [JP]


Application No.: US20120328699A1  Published: 27/Dec/2012

Title: METHOD AND COMPOSITION FOR TREATMENT OF SKELETAL DYSPLASIAS

Applicant/Assignee: HEPACORE LTD

Application No.: 13/006129   Filing Date: 13/Jan/2011

Abstract:

The present invention relates to a method for the treatment of skeletal dysplasia by administering to a patient a composition comprising a therapeutically effective amount of at least one C-type natriuretic peptide (CNP).

Priority: IL20010142118 Applic. Date: 2001-03-20; US2009-612645 Applic. Date: 2009-11-04; US2007-840631 Applic. Date: 2007-08-17; US2003-664605 Applic. Date: 2003-09-15; WO2002IL00229 Applic. Date: 2002-03-20; US2001-276939P Applic. Date: 2001-03-20

Inventor: GOLEMBO MYRIAM [IL]; YAYON AVNER [IL]


Application No.: US20120329817A1  Published: 27/Dec/2012

Title: MUCOSAL BIOADHESIVE SLOW RELEASE CARRIER FOR DELIVERING ACTIVE PRINCIPLES

Applicant/Assignee: BIOALLIANCE PHARMA

Application No.: 13/565653   Filing Date: 02/Aug/2012

Abstract:

A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.

Priority: EP20060290480 Applic. Date: 2006-03-24; US2008-225470 Applic. Date: 2008-10-09; WO2007IB01662 Applic. Date: 2007-03-23

Inventor: COSTANTINI DOMINIQUE [FR]; LEMARCHAND CAROLINE [FR]

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