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US GRANTED PATENTS IN BLOOD ANTICLOT DRUGS AND DEVICES PUBLISHED IN 2010



Patent No.: US7645253B2  Issued: 12/Jan/2010

Title: Wearable ultrafiltration device

Applicant/Assignee: NATIONAL QUALITY CARE, INC

Application No.: 10/846618   Filing Date: 17/May/2004

Abstract:

An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.

Priority: US2001-085349 Applic. Date: 2001-11-16

Inventor: GURA VICTOR [US]; RAMBOD EDMOND [US]


Patent No.: US7645425B2  Issued: 12/Jan/2010

Title: Protease Inhibitor Sample Collection System

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 11/937954   Filing Date: 09/Nov/2007

Abstract:

A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent includes one or more protease inhibitors.

Priority: US2003-436263 Applic. Date: 2003-05-13; US20020379399P Applic. Date: 2002-05-13

Inventor: HAYWOOD BRUCE [US]; DASTANE AJIT [US]; LIN FU-CHUNG [US]


Patent No.: US7645591B2  Issued: 12/Jan/2010

Title: Method for determining the nature of an infection

Applicant/Assignee:

Application No.: 10/479656   Filing Date: 14/Jan/2004

Abstract:

The present invention relates to differential diagnostics, and provides a method for determining if an infection detected in a patient is of bacterial or of viral origin. In the method chemiluminescence of phagocytic cells induced by non-opsonized zymosan in a blood sample is measured and the expression of Complement Receptor 1 (cr1) is determined. The value when multiplying chemiluminescence with the CR1 expression is compared with method-specific average values for bacterial and viral infections. The invention also provides test kits for accomplishing the method of the invention.

Priority: FI20010001168 Applic. Date: 2001-06-04; WO2002FI00472 Applic. Date: 2002-06-03

Inventor: LILIUS ESA-MATTI [FI]; NUUTILA JARI [FI]


Patent No.: US7651481B2  Issued: 26/Jan/2010

Title: Self-sealing male connector device with collapsible body

Applicant/Assignee: CAREFUSION 303 INC

Application No.: 11/026002   Filing Date: 30/Dec/2004

Abstract:

A self-sealing male connector device for connection with a female Luer connector. The device has an elongated male body configured with lengthwise relatively rigid and flexible wall segments cooperating to allow the body to be radially compressed from an expanded configuration to a contracted configuration. A closure cap formed with a resealable aperture is disposed on the distal end of the male body so as to be responsive to the compression of the male body. The relatively flexible wall segments may be installed within notches in the male body or be formed integral with the relatively rigid wall segments.

Priority:

Inventor: RAYBUCK JOHN [US]


Patent No.: US7651696B2  Issued: 26/Jan/2010

Title: Implantable device for treating disease states and methods of using same

Applicant/Assignee: GLOBAL GENE THERAPIES, INC NEXEON MEDICAL SYSTEMS, INC

Application No.: 10/864936   Filing Date: 09/Jun/2004

Abstract:

Methods and apparatus are provided for delivering drugs, gene vectors, naturally-occurring or synthetic hormones or proteins or other bioactive agents within a patient's vasculature. In a preferred embodiment, the apparatus comprises a material that elutes or secretes a bioactive agent and is held in place within the patient's vessel by an anchor. The material may comprise a biocompatible, and optionally, absorbable matrix, or a culture medium that sustains and nourishes stem cells, spleen cells or pancreatic islets or other beneficial cells. The anchor and material are sized and/or collapsible from a delivery configuration, in which the anchor and material may be delivered into the patient's vasculature within a delivery sheath, to a deployed configuration, wherein the anchor engages an interior wall of the patient's vessel.

The apparatus of the invention may be temporarily or permanently implanted, and may in addition self reconfigure after a predetermined period of residency.

Priority: US2000-648257 Applic. Date: 2000-08-25

Inventor: BATES MARK C [US]


Patent No.: US7659052B2  Issued: 09/Feb/2010

Title: Medium comprising cryoprecipitate and method for preserving platelets, red blood cells and other cells without a nucleus

Applicant/Assignee:

Application No.: 12/232482   Filing Date: 18/Sep/2008

Abstract:

The present invention provides a platelet-containing composition prepared by contacting platelets with a medium for preserving. The medium comprises anticoagulant, cryoprecipitate and thrombin. The present invention also provides a method for long-term preservation of platelets, comprising the steps of: (a) adding an anticoagulant, cryoprecipitate, thrombin in normal saline

(b) adding a platelet-containing medium into the solution formed in step (a)

and (c) lyophilizing the platelet-containing solution formed in step (b). Moreover, the present invention yet provides a medium for preserving non-nucleus cells.

Priority: TW20040119184 Applic. Date: 2004-06-29; US2005-157838 Applic. Date: 2005-06-22

Inventor: SU CHENG YAO [TW]; LIN CHENG CHIH [TW]


Patent No.: US7661541B2  Issued: 16/Feb/2010

Title: Porous spun polymeric structures and method of making same

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 11/496187   Filing Date: 31/Jul/2006

Abstract:

A non-woven polymeric matrix for separating leukocytes from a blood sample includes a non-woven three dimensional matrix formed from polymeric fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 mum to about 250 mum, and a plurality of connections between the plurality of fibers. The matrix is configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells. Methods of making and using the matrix are also provided.

Priority: US2002-331213 Applic. Date: 2002-12-30

Inventor: DAO KINH-LUAN LENNY D [US]; CHIN YEM [US]; ZHONG SHENG-PING SAMUEL [US]; MOHAN KSHITIJ [US]; VU LIEM [US]


Patent No.: US7662558B2  Issued: 16/Feb/2010

Title: Method of profiling gene expression in a human subject

Applicant/Assignee: CHONDROGENE LIMITED GENENEWS CORPORATION

Application No.: 10/803858   Filing Date: 18/Mar/2004

Abstract:

The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-associated genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.

Priority: US2002-268730 Applic. Date: 2002-10-09; US2000-477148 Applic. Date: 2000-01-04; US19990115125P Applic. Date: 1999-01-06

Inventor: LIEW CHOONG-CHIN [CA]


Patent No.: US7666215B2  Issued: 23/Feb/2010

Title: System and method for determining and controlling core body temperature

Applicant/Assignee: RADIANT MEDICAL,INC RADIANT MEDICAL, INC

Application No.: 10/525625   Filing Date: 03/Oct/2005

Abstract:

Systems and methods for accurate temperature modification of a patient, or selected regions thereof, including inducing hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within a control unit. A temperature measurement scheme for obtaining body core temperature is provided, including methods of obtaining and analyzing temperature data to provide feedback to the control unit for use in controlling the heating and cooling of the heat exchange medium so as to heat or cool a patient to a desired target temperature.

Priority: US20020410096P Applic. Date: 2002-09-12; WO2003US28683 Applic. Date: 2003-09-12

Inventor: CALLISTER JEFFREY [US]; STULL PAUL M [US]; WU ANDREW E [US]; SCOTT DAVID J [US]


Patent No.: US7674769B2  Issued: 09/Mar/2010

Title: Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (TFPI)

Applicant/Assignee: NOVARTIS VACCINES AND DIAGNOSTICS, INC

Application No.: 10/270478   Filing Date: 15/Oct/2002

Abstract:

Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of developing this condition. The methods involve the use of continuous intravenous infusion of TFPI or a TFPI analog, preferably at low doses to avoid adverse side effects.

Priority: US20010328806P Applic. Date: 2001-10-15

Inventor: CREASEY ABLA [US]


Patent No.: US7682391B2  Issued: 23/Mar/2010

Title: Methods of implanting a prosthetic mitral heart valve having a contoured sewing ring

Applicant/Assignee: EDWARDS LIFESCIENCES CORPORATION

Application No.: 11/181065   Filing Date: 13/Jul/2005

Abstract:

A prosthetic mitral heart valve including a contoured sewing ring that better matches the mitral valve annulus. The sewing ring includes an inflow end and an outflow end, the outflow and having at least one raised portion. There may be two raised portions located approximately 120 DEG apart from each other and designed to register with two anterior trigones of the mitral valve annulus. The sewing ring may be formed by a suture-permeable annular member surrounded by a fabric covering, the annular member desirably being molded of silicone. The raised portion(s) may gently curve upward to a height of about 2 mm above the adjacent portions of the outflow end of the sewing ring. The sewing ring may also be constructed so as to be more flexible around a posterior aspect than around an anterior aspect to accommodate calcified tissue more commonly found around the posterior annulus.

The contoured sewing ring can be combined with various types of heart valve including bioprosthetic and mechanical valves. A bioprosthetic heart valve of the present invention may include a support stent having three outflow commissures alternating with three inflow cusps, with two of the commissures being located at the same place as two raised portions of the sewing ring. A method of implant includes tilting the prosthetic heart valve in the mitral annulus so that a posterior commissure angles away from the ventricular wall and reduces the chance of contact therebetween.

Priority: US2005-181190 Applic. Date: 2005-07-13

Inventor: JOHNSON DERRICK [US]


Patent No.: US7704235B2  Issued: 27/Apr/2010

Title: System and device for medically treating an individual

Applicant/Assignee:

Application No.: 12/288905   Filing Date: 24/Oct/2008

Abstract:

A system for medically treating/vaccinating an individual comprising a first syringe, containing an anticoagulant material therein, for drawing a sample of blood from the individual. A centrifuge is provided for centrifuging the sample of blood contained within the first syringe to obtain a buffy coat. A second syringe comprising a second plunger and at least one microtubule member containing one of a treatment agent and a vaccine antigen. At least one open end formed within the at least one microtubule member for drawing a portion of the buffy coat therein and exposing the buffy coat to one of the treatment agent and vaccine antigen. A second needle capable of being attached onto the second syringe for introducing the exposed sample into the individual to effect treatment/vaccination thereof.

This system is capable of allowing a plurality of treatment agents and/or vaccine antigens to be simultaneously applied to an individual.

Priority: US2006-507876 Applic. Date: 2006-08-22

Inventor: NALIN DAVID R [US]


Patent No.: US7704454B1  Issued: 27/Apr/2010

Title: Methods and devices for processing blood

Applicant/Assignee: CARIDIANBCT, INC

Application No.: 10/680950   Filing Date: 08/Oct/2003

Abstract:

Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.

Priority:

Inventor: LANGLEY ROBERT W [US]; FELT THOMAS J [US]; VAN WAEG GEERT [BE]; BAINBRIDGE MARLENE ADELE [US]


Patent No.: US7708710B2  Issued: 04/May/2010

Title: Method and apparatus for collecting and processing blood

Applicant/Assignee: FENWAL, INC

Application No.: 10/826420   Filing Date: 16/Apr/2004

Abstract:

Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.

Priority: US20030532310P Applic. Date: 2003-12-23

Inventor: MIN KYUNGYOON [US]; BROWN RICHARD I [US]


Patent No.: US7713551B2  Issued: 11/May/2010

Title: Gel stabilized nanoparticulate active agent compositions

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LTD

Application No.: 10/659706   Filing Date: 11/Sep/2003

Abstract:

Disclosed is a solid or semi-solid gelatin nanoparticulate active agent dosage form comprising at least one nanoparticulate active agent and at least one gel forming substance which exhibits gelation sufficient to retain excess water in the solid or semi-solid gelatin form. The active agent particles have an effective average diameter prior to inclusion in the dosage form of less than about 2000 nm. The dosage form of the invention has the advantages of easy administration combined with rapid dissolution of the active agent following administration.

Priority: US20020409587P Applic. Date: 2002-09-11

Inventor: MCGURK SIMON L [US]; CZEKAI DAVID A [US]


Patent No.: US7718421B2  Issued: 18/May/2010

Title: Sample processing

Applicant/Assignee: IQUUM, INC

Application No.: 10/773775   Filing Date: 05/Feb/2004

Abstract:

A sample processing tubule may include a first segment, a second segment, and a third segment. Each segment may be defined by the tubule, may be fluidly isolated, at least in part by a breakable seal, may be so expandable as to receive a volume of fluid expelled from another segment, and may be so compressible as to contain substantially no fluid when so compressed. Each segment may contain at least one reagent.

Priority: US20030445304P Applic. Date: 2003-02-05

Inventor: CHEN SHUQI [US]; LEMIEUX BERTRAND [US]; WANG ZIHUA [US]; KOPCZYNSKI KEVIN R [US]; CHEN LINGJUN [US]


Patent No.: US7722855B2  Issued: 25/May/2010

Title: Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell

Applicant/Assignee: UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI

Application No.: 10/564284   Filing Date: 13/Jul/2004

Abstract:

The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of said vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.

Priority: EP20030291752 Applic. Date: 2003-07-15; WO2004IB02265 Applic. Date: 2004-07-13

Inventor: TATISCHEFF IRENE [FR]; ALFSEN ANNETTE [FR]; LAVIALLE FRANCOISE [FR]


Patent No.: US7723017B2  Issued: 25/May/2010

Title: Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation

Applicant/Assignee: HEMANEXT LLC THE TRUSTEES OF BOSTON UNIVERSITY

Application No.: 11/138135   Filing Date: 26/May/2005

Abstract:

There are provided methods and compositions for the storage of red blood cells. The compositions are metabolic supplements that are preferably added to refrigerated red blood cells suspended in an additive solution. Red blood cells are preferably stored under conditions of oxygen-depletion. Metabolic compositions comprises pyruvate, inosine, adenine, and optionally dibasic sodium phosphate and/or monobasic sodium phosphate.

Priority: US2002-295772 Applic. Date: 2002-11-15; US20010332409P Applic. Date: 2001-11-16

Inventor: BITENSKY MARK W [US]; YOSHIDA TATSURO [US]


Patent No.: US7727576B2  Issued: 01/Jun/2010

Title: System and a method for producing layered oral dosage forms

Applicant/Assignee: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P

Application No.: 10/825870   Filing Date: 16/Apr/2004

Abstract:

A method for producing an oral medication includes dispensing a structural material, the structural material including one of a polymer or a gelatin, curing the structural material, and dispensing a jettable pharmaceutical solution onto the cured structural material.

Priority:

Inventor: FIGUEROA IDDYS D [US]; RUIZ ORLANDO [US]


Patent No.: US7732210B2  Issued: 08/Jun/2010

Title: Multi-Analyte Reference Solutions

Applicant/Assignee: INSTRUMENTATION LABORATORY COMPANY

Application No.: 12/203486   Filing Date: 03/Sep/2008

Abstract:

The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution.

Priority: US2003-733871 Applic. Date: 2003-12-11; US20020432373P Applic. Date: 2002-12-11

Inventor: CONLON DENNIS ROBERT [US]; MANSOURI SOHRAB [US]; VAGO GIANNANTONIO [IT]


Patent No.: US7735652B2  Issued: 15/Jun/2010

Title: Apparatus and method for continuous particle separation

Applicant/Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY

Application No.: 11/809559   Filing Date: 31/May/2007

Abstract:

The invention is directed to an apparatus and a method of separating particles, such as cells, from a heterogeneous fluid, such as blood, where the particles have a large range of sizes.

Priority: US20060809933P Applic. Date: 2006-06-01

Inventor: INGLIS DAVID WILLIAM [AU]; DAVIS JOHN [US]; AUSTIN ROBERT [US]; STURM JAMES [US]


Patent No.: US7736593B2  Issued: 15/Jun/2010

Title: Device and methods for collection of biological fluid sample and treatment of selected components

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 10/912263   Filing Date: 05/Aug/2004

Abstract:

A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.

Priority: US20030492313P Applic. Date: 2003-08-05

Inventor: DASTANE AJIT N [US]; MANOUSSAKIS DIMITRIOS [US]; BATTLES CHRISTOPHER A [US]; DICESARE PAUL [US]; RADZIUNAS JEFFREY [US]


Patent No.: US7745106B2  Issued: 29/Jun/2010

Title: Methods and devices for separating liquid components

Applicant/Assignee: CASCADE MEDICAL ENTERPRISES, LLC

Application No.: 10/607580   Filing Date: 26/Jun/2003

Abstract:

Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.

Priority: IT1997MI01490 Applic. Date: 1997-06-24; US2002-053247 Applic. Date: 2002-01-15; US2000-446729 Applic. Date: 2000-03-03; WO1998IT00173 Applic. Date: 1998-06-24; US20020392669P Applic. Date: 2002-06-27

Inventor: BERETTA ROBERTO C [IT]; GRIPPI NICHOLAS A [US]


Patent No.: US7745107B2  Issued: 29/Jun/2010

Title: Method for assaying flowing media for microbial toxins

Applicant/Assignee:

Application No.: 10/474694   Filing Date: 07/Apr/2004

Abstract:

Testing of flowing media for microbial toxins via whole blood incubation in a flow vessel containing a separation element and assaying for mediators.

Priority: DE20011018446 Applic. Date: 2001-04-12; WO2002DE01086 Applic. Date: 2002-03-25

Inventor: HARTUNG THOMAS [DE]


Patent No.: US7745180B2  Issued: 29/Jun/2010

Title: Device and method for high-throughput quantification of mRNA from whole blood

Applicant/Assignee: HITACHI CHEMICAL CO., LTD HITACHI CHEMICAL RESEARCH CENTER, INC

Application No.: 10/796298   Filing Date: 09/Mar/2004

Abstract:

Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.

Priority: US2003-698967 Applic. Date: 2003-10-30; WO2003US12895 Applic. Date: 2003-04-24; US20020375472P Applic. Date: 2002-04-24

Inventor: MITSUHASHI MASATO [US]


Patent No.: US7758547B2  Issued: 20/Jul/2010

Title: Process for controlling an infusion device

Applicant/Assignee: GAMBRO LUNDIA AB

Application No.: 11/104446   Filing Date: 13/Apr/2005

Abstract:

A process comprises the phases of: activating a pusher, which exerts a push force on a plunger of a syringe containing the infusion liquid

measuring the push force by means of a load cell

comparing the push force with a maximum threshold

halting the pusher when the maximum threshold is exceeded

after a predetermined pause, restarting the pusher and emitting a consent signal indicating correct loading of the syringe if, within a certain time from the restart, the push force again exceeds the maximum threshold. The infusion device serves to inject an anticoagulant into an extracorporeal blood circuit. The control process guarantees against loss of infusion due to an incorrect initial loading of the syringe.

Priority: IT2004MO00086 Applic. Date: 2004-04-20; US20040522439P Applic. Date: 2004-10-01

Inventor: TONELLI CLAUDIO [IT]; LIGABUE ANDREA [IT]; CESTARI SILVANO [IT]


Patent No.: US7758900B2  Issued: 20/Jul/2010

Title: MULTI-PART SUBSTITUTION INFUSION FLUIDS AND MATCHING ANTICOAGULANTS

Applicant/Assignee: BAXTER INTERNATIONAL INC BAXTER HEALTHCARE S.A

Application No.: 11/678525   Filing Date: 23/Feb/2007

Abstract:

A multi-part substitution infusion fluid for an extracorporeal blood treatment and methods for using same are provided. Generally, the multi-part substitution fluid comprises a first solution composed of electrolites but without divalent cations and a second solution comprising divalent cations. Another embodiment includes a third solution comprising a matching citrate/citric acid anticoagulant. The described methods of using the multi-part substitution infusion fluids significantly reduce risks associated with various extracorporeal blood treatments.

Priority: EP19990201302 Applic. Date: 1999-04-26; US2003-742137 Applic. Date: 2003-12-19; US2001-959543 Applic. Date: 2001-10-23; WO2000EP03583 Applic. Date: 2000-04-20

Inventor: CHANG PETER C [NL]; LANNOY JEAN-MICHEL [FR]


Patent No.: US7763597B2  Issued: 27/Jul/2010

Title: Salts

Applicant/Assignee: ASTRAZENECA AB

Application No.: 11/839842   Filing Date: 16/Aug/2007

Abstract:

There is provided pharmaceutically-acceptable acid addition salts of compounds of formula (I), wherein R1 represents C1-2 alkyl substituted by one or more fluoro substituents

R2 represents C1-2 alkyl

and n represents 0, 1 or 2, which salts are useful as prodrugs of competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required.

Priority: SE20020001661 Applic. Date: 2002-05-31; US2005-516422 Applic. Date: 2005-05-20; WO2003SE00859 Applic. Date: 2003-05-27

Inventor: AHLQVIST MATTI [SE]; BOHLIN MARTIN [SE]; INGHARDT TORD [SE]; LUNDBLAD ANITA [SE]; SIGFRIDSSON CARL-GUSTAF [SE]


Patent No.: US7767459B2  Issued: 03/Aug/2010

Title: METHOD FOR DETERMINING PROTHROMBIN TIME

Applicant/Assignee:

Application No.: 11/909208   Filing Date: 20/Mar/2006

Abstract:

A method for determining prothrombin time of a plasma or whole blood sample includes measuring prothrombin time for at least two different dilutions for a test sample to determine tmin or INRmin. The prothrombin time for at least two different dilutions for normal plasma is measured to determine tmin or INRmin values for normal plasma. Next, tPivka or INRPivka values are calculated by subtracting the value for normal plasma from the value for the test sample. The Pivka corrected prothrombin time for the test sample is calculated by subtracting tPivka or INRPivka from the prothrombin time measured for the test sample.

Priority: FI20050000298 Applic. Date: 2005-03-21; WO2006FI50104 Applic. Date: 2006-03-20

Inventor: HORSTI JUHA [FI]


Patent No.: US7767860B2  Issued: 03/Aug/2010

Title: SUBSTITUTED AMINO ALCOHOLS

Applicant/Assignee: AUSPEX PHARMACEUTICALS, INC

Application No.: 12/203581   Filing Date: 03/Sep/2008

Abstract:

Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Priority: US20070970376P Applic. Date: 2007-09-06

Inventor: GANT THOMAS G [US]; SARSHAR SEPEHR [US]


Patent No.: US7772371B2  Issued: 10/Aug/2010

Title: Stimulators of Factor X activated (FXa) as new topical antihemorrhagic agents

Applicant/Assignee: THROMBOTARGETS CORPORATION

Application No.: 11/498590   Filing Date: 03/Aug/2006

Abstract:

The activated coagulation Factor X (FXa) stimulating agents may be used in the treatment of hemorrhages in a subject. Compounds and combinations are described which are particularly useful for the topical treatment of hemorrhaging in healthy subjects or in patients with hemorrhagic diathesis.

Priority: EP20050380179 Applic. Date: 2005-08-03; US20050719643P Applic. Date: 2005-09-21

Inventor: EGEA JAVIER PEDRENO [ES]; CATASUS LUIS CAVEDA [US]


Patent No.: US7776580B2  Issued: 17/Aug/2010

Title: Magnetism based rapid cell separation

Applicant/Assignee: CAPITALBIO CORPORATION TSINGHUA UNIVERSITY

Application No.: 10/538498   Filing Date: 31/Dec/2002

Abstract:

This invention relates generally to the field of cell seperation. In particular, the invention provides processes for isolating a target cell, cellular organelle or virus from a sample, using inter alia, nonspecific binding between a target cell, cellular organelle or virus with a magnetic microbead modified to comprise hydroxyl, carboxyl or epoxy groups.

Priority: CN20021053992 Applic. Date: 2002-12-09; WO2002CN00942 Applic. Date: 2002-12-31

Inventor: ZHANG XU [CN]; XIE XIN [CN]; CHEN DEPU [CN]; FEI WEIYANG [CN]; CHENG JING [CN]


Patent No.: US7776583B2  Issued: 17/Aug/2010

Title: Methods and apparatuses for conducting assays

Applicant/Assignee: MESO SCALE DIAGNOSTICS, LLC MESO SCALE TECHNOLOGIES, LLC

Application No.: 11/145528   Filing Date: 03/Jun/2005

Abstract:

Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.

Priority: US20040576710P Applic. Date: 2004-06-03

Inventor: BILLADEAU MARK A [US]; DEBAD JEFF D [US]; GLEZER ELI N [US]; LELAND JONATHAN K [US]; WIJAYAWARDHANA CHARLES A [DE]


Patent No.: US7780622B2  Issued: 24/Aug/2010

Title: Artificial Blood Vessel

Applicant/Assignee: VASCUTEK LIMITED TERUMO CORPORATION

Application No.: 11/792498   Filing Date: 14/Feb/2005

Abstract:

There is described an artificial blood vessel for use in a region of a living body which needs to be repeatedly pierced with a needle. The artificial blood vessel includes a main section having a vessel wall which includes a laminated assembly comprising an inner layer, an outer layer, and an intermediate layer positioned therebetween, and a pair of anastomotic sections disposed on the respective opposite ends of the main section. Each of the anastomotic sections has an intermediate layer thinner than the intermediate layer of the main section or is free of an intermediate layer, so that the anastomotic section as a vessel wall thinner than the main section.

Priority: WO2005GB00521 Applic. Date: 2005-02-14

Inventor: FITZPATRICK CHARLES [GB]; OKUBO TADANORI [GB]


Patent No.: US7780988B2  Issued: 24/Aug/2010

Title: Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

Applicant/Assignee: BEND RESEARCH, INC

Application No.: 10/351568   Filing Date: 24/Jan/2003

Abstract:

Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.

Priority: US20020353986P Applic. Date: 2002-02-01

Inventor: BEYERINCK RONALD A [US]; RAY RODERICK J [US]; DOBRY DAN E [US]; SETTELL DANA M [US]


Patent No.: US7788038B2  Issued: 31/Aug/2010

Title: Biological information and blood treating device information control system, biological information and blood treating device information control device, and biological information and blood treating device information control method

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 10/450648   Filing Date: 16/Jun/2003

Abstract:

The invention comprises a patient information server device which automatically accumulates together with time information: biological information detected by a bedside monitoring device of a patient or a biological-measuring device

biological information and device information detected by a blood purification device which treats a blood sample taken from the patient

and blood information detected by a circulating blood volume measuring device that detects blood information about a circulating blood sample taken from the patient. A client device simultaneously and chronologically displays or records the patient information stored in the patient information server device. Through this arrangement, it is possible to obtain on a real time basis the biological information of a human body such as a patient's body, and the device information, for example, of a blood treating device.

Priority: JP20000397609 Applic. Date: 2000-12-27; WO2001JP11509 Applic. Date: 2001-12-27

Inventor: OSHITA SHUZO [JP]; KURODA YASUHIRO [JP]; OKAHISA TOSHIYA [JP]; OHNISHI YOSHIAKI [JP]; OKUMURA NORIKO [JP]


Patent No.: US7794750B2  Issued: 14/Sep/2010

Title: CONTROLLED-RELEASE FORMULATIONS, METHOD OF MANUFACTURE, AND USE THEREOF

Applicant/Assignee: MUTUAL PHARMACEUTICAL COMPANY, INC

Application No.: 12/330280   Filing Date: 08/Dec/2008

Abstract:

The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions.

Priority: US2008-143460 Applic. Date: 2008-06-20

Inventor: NARINGREKAR GANDHA V [US]; ARNOLD KRISTIN A [US]; ERKOBONI DAVID [US]


Patent No.: US7797825B2  Issued: 21/Sep/2010

Title: METHOD OF MAKING AN ELECTROCHEMICAL SENSOR

Applicant/Assignee: THERASENSE, INC ABBOTT DIABETES CARE INC

Application No.: 11/929994   Filing Date: 30/Oct/2007

Abstract:

A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.

Priority: US2005-204551 Applic. Date: 2005-08-16; US2003-405765 Applic. Date: 2003-03-31; US2000-598776 Applic. Date: 2000-06-16; US1998-034422 Applic. Date: 1998-03-04

Inventor: SAY JAMES [US]; TOMASCO MICHAEL F [US]; HELLER ADAM [US]; GAL YORAM [IL]; ARIA BEHRAD [US]; HELLER EPHRAIM [US]; PLANTE PHILLIP JOHN [US]; VREEKE MARK S [US]


Patent No.: US7798977B2  Issued: 21/Sep/2010

Title: Disposable Blood Sampling Device

Applicant/Assignee: KUN SHAN MEDSAFE MEDICAL TECH CO., LTD

Application No.: 11/781237   Filing Date: 21/Jul/2007

Abstract:

A disposable blood sampling device is disclosed herein, which includes a plunger, a rubber stopper, a barrel, a sealing member, a needle holder, a protection sleeve, an anticoagulant storing tube and a needle sheath. In use, the disposable blood sampling device is deconstructed by removing each component therefrom and is unable to be assembled again for recycling. Furthermore, the needle can be hidden in the protection sleeve before it is detached from the blood sampling device, which effectively prevents a medical operator from being hurt or even infected by the needle.

Priority: TW20060218599U Applic. Date: 2006-10-20

Inventor: CAI JIAN [CN]


Patent No.: US7803143B2  Issued: 28/Sep/2010

Title: Implantable hemodialysis access device

Applicant/Assignee: STD MED, INC

Application No.: 11/269098   Filing Date: 08/Nov/2005

Abstract:

An implantable hemodialysis port includes a housing and a septum, the housing being formed from a flexible material and including a plurality of chambers. The chambers are fluidly interconnected with one another by integrated outlet passageways. Each of the chambers includes a sidewall portion and a funnel portion tapering from the sidewall portion. The septum encloses each of the chambers.

Priority: US2001-842458 Applic. Date: 2001-04-26; US20000199714P Applic. Date: 2000-04-26

Inventor: TALLARIDA STEVEN J [US]; ETTLINGER MARK [US]


Patent No.: US7811782B2  Issued: 12/Oct/2010

Title: Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease

Applicant/Assignee: HEMOSHEAR, LLC

Application No.: 12/007483   Filing Date: 10/Jan/2008

Abstract:

Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the cells. Rotation of the cone creates time-varying shear stresses. This model closely mimics the physiological hemodynamic forces imparted on endothelial cells in vivo. A TRANSWELL coculture dish (i.e., a coculture dish comprising an artificial porous membrane) may be incorporated, permitting two, three, or more different cell types to be physically separated within the culture dish environment. In-flow and out-flow tubing may be used to supply media, drugs, etc. separately and independently to both the inner and outer chambers.

The physical separation of the cell types permits each cell type to be separately isolated for analysis.

Priority: US20070879710P Applic. Date: 2007-01-10

Inventor: BLACKMAN BRETT R [US]; WAMHOFF BRIAN R [US]


Patent No.: US7815590B2  Issued: 19/Oct/2010

Title: Devices for maintaining patency of surgically created channels in tissue

Applicant/Assignee: BRONCUS TECHNOLOGIES, INC

Application No.: 10/894876   Filing Date: 19/Jul/2004

Abstract:

Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and/or decompresses hyper-inflated lungs.

Priority: US2001-908177 Applic. Date: 2001-07-18; US2000-633651 Applic. Date: 2000-08-07; US20030488332P Applic. Date: 2003-07-18; US19990147528P Applic. Date: 1999-08-05; US20000176141P Applic. Date: 2000-01-14

Inventor: COOPER JOEL D [US]


Patent No.: US7816124B2  Issued: 19/Oct/2010

Title: Diagnostic whole blood and plasma apparatus

Applicant/Assignee: CHROMEDX INC

Application No.: 11/432616   Filing Date: 12/May/2006

Abstract:

An apparatus suitable for measuring at least one plasma analyte in plasma extracted from a whole blood sample within the apparatus is provided. The apparatus can be adapted for insertion into a slot in a meter, which can preferably perform at least spectroscopic or biosensor measurement. The apparatus comprises a whole blood flow path, which begins at the inlet opening of the apparatus, and terminates at a vent or a suction chamber. Included in the blood flow path is a flow-through filtration chamber. The filtration chamber comprises at least one membrane separating a blood compartment from a plasma compartment. The apparatus further comprises a plasma flow path, which begins at the plasma compartment and terminates at a vent or a suction chamber. The plasma flow path includes a plasma analyte signal providing means.

The signal is transmitted to a processor in the meter for preparing analyte measurements.

Priority: CA20052507323 Applic. Date: 2005-05-13

Inventor: SAMSOONDAR JAMES [CA]


Patent No.: US7820371B2  Issued: 26/Oct/2010

Title: Method for removing viruses and leukocytes from blood using a surface comprising hydroxyl and polyethylene glycol groups

Applicant/Assignee: ASAHI MEDICAL CO., LTD ASAHI KASEI KURARAY MEDICAL CO., LTD

Application No.: 11/772448   Filing Date: 02/Jul/2007

Abstract:

It is intended to provide a method whereby a virus and leukocytes can be simultaneously eliminated from virus-containing blood and platelets can be recovered at a high yield, and a material and an apparatus therefor. A water-soluble carrier having surface which is capable of capturing a virus and leukocytes in blood but allows the permeation of platelets therethrough is brought into contact with virus-containing blood. Thus the virus and leukocytes can be simultaneously removed from the blood while platelets can be recovered at a high yield.

Priority: JP20010318512 Applic. Date: 2001-10-16; US2004-492652 Applic. Date: 2004-09-03; WO2002JP10766 Applic. Date: 2002-10-16

Inventor: ONODERA HIROKAZU [JP]; YOSHIDA MAKOTO [JP]


Patent No.: US7820715B2  Issued: 26/Oct/2010

Title: Crystal Comprising (2R)-2-Propyloctanoic Acid and Amine

Applicant/Assignee: ONO PHARMACEUTICAL CO., LTD

Application No.: 11/579071   Filing Date: 27/Apr/2005

Abstract:

Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5% e.e., which has not been obtained hitherto.

Priority: JP20040134655 Applic. Date: 2004-04-28; WO2005JP08462 Applic. Date: 2005-04-27

Inventor: HASEGAWA TOMOYUKI [JP]; KAWANAKA YASUFUMI [JP]; KASAMATSU EIJI [JP]


Patent No.: US7828761B2  Issued: 09/Nov/2010

Title: WEARABLE ULTRAFILTRATION DEVICE

Applicant/Assignee: NATIONAL QUALITY CARE, INC FRESENIUS MEDICAL CARE HOLDINGS, INC

Application No.: 11/830695   Filing Date: 30/Jul/2007

Abstract:

An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.

Priority: US2002-251937 Applic. Date: 2002-09-19; US2001-085349 Applic. Date: 2001-11-16

Inventor: GURA VICTOR [US]; RAMBOD EDMOND [US]


Patent No.: US7829549B2  Issued: 09/Nov/2010

Title: Methods for treating bleeding disorders using sulfated polysaccharides

Applicant/Assignee: BAXTER INTERNATIONAL INC BAXTER HEALTHCARE S.A BAXTER HEALTHCARE S. A

Application No.: 12/386026   Filing Date: 13/Apr/2009

Abstract:

Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with one another, or with other medications (such as factors VII, VIII and IX) to promote hemostasis. In particular, the use of NASPs in treatment of bleeding disorders, including congenital coagulation disorders, acquired coagulation disorders, and trauma induced hemorrhagic conditions is described.

Priority: US2005-140504 Applic. Date: 2005-05-27; US20040574845P Applic. Date: 2004-05-27

Inventor: JOHNSON KIRK W [US]


Patent No.: US7837708B2  Issued: 23/Nov/2010

Title: Accelerated healing with intraoperative combination of suture and autogenous blood components

Applicant/Assignee: ARTHREX, INC

Application No.: 11/112003   Filing Date: 22/Apr/2005

Abstract:

A suture combined intraoperatively with autogenous blood components. At least one strand of suture is placed into a sterile container. Blood obtained from a patient is separated, using a centrifuge, for example, to retrieve certain healing components such as autogenous growth factors, to obtain an autogenous blood suspension. The autogenous blood suspension is added to the sterile container containing the strand of suture. The suture wicks up biologic components of the autogenous blood suspension to produce an enhanced suture. Surgical repairs using the enhanced suture are conducted by suturing a tear to itself or to bone, for example. Post-operatively, the biologic components leach from the suture to accelerate healing of the repair.

Priority: US20040564241P Applic. Date: 2004-04-22

Inventor: SCHMIEDING REINHOLD [US]; GRAFTON R DONALD [US]


Patent No.: US7842232B2  Issued: 30/Nov/2010

Title: STERILIZATION OF DISPERSIONS OF NANOPARTICULATE ACTIVE AGENTS WITH GAMMA RADIATION

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LIMITED ELAN PHARMA INTERNATIONAL, LTD

Application No.: 10/851661   Filing Date: 24/May/2004

Abstract:

The present invention relates to methods for sterilization of dispersions of one or more nanoparticulate active agents via gamma irradiation.

Priority: US20030472434P Applic. Date: 2003-05-22

Inventor: BOSCH H WILLIAM [US]; KELLER JANINE [US]


Patent No.: US7846193B2  Issued: 07/Dec/2010

Title: Inhibition of platelet activation, aggregation and/or adhesion by hypothermia

Applicant/Assignee: RADIANT MEDICAL, INC ZOLL CIRCULATION, INC

Application No.: 11/501442   Filing Date: 08/Aug/2006

Abstract:

A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 DEG C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C).

If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

Priority: US2003-408617 Applic. Date: 2003-04-07; US2001-790249 Applic. Date: 2001-02-21

Inventor: DAE MICHAEL W [US]; MACHOLD TIMOTHY R [US]; KELLER WADE A [US]


Patent No.: US7850634B2  Issued: 14/Dec/2010

Title: METHOD FOR COLLECTING A DESIRED BLOOD COMPONENT AND PERFORMING A PHOTOPHERESIS TREATMENT

Applicant/Assignee: THERAKOS, INC

Application No.: 11/613021   Filing Date: 19/Dec/2006

Abstract:

An improved method for separating whole blood into components and collecting a desired blood component. The method allows a desired blood component to be subjected to centrifugal forces within a separator for prolonged periods of time, yielding a cleaner cut and higher yield of the desired blood component. Whole blood is drawn from a source and pumped into a separator, the undesired blood components are removed from the separator at rates so as to build up the desired blood component in the separator. The desired blood component is only removed after a predetermined amount of the desired blood component has built up in the separator. It is preferred that the desired blood component be buffy coat and that the method be used to perform photopheresis treatments.

In another aspect, the invention is a method of performing a full photopheresis treatment to treat diseases in a reduced time, preferably less than about 70 minutes, and more preferably less than about 45 minutes.

Priority: US2003-654803 Applic. Date: 2003-09-03; US2003-375629 Applic. Date: 2003-02-27; US20020361287P Applic. Date: 2002-03-04

Inventor: BRIGGS DENNIS [US]


Patent No.: US7850995B2  Issued: 14/Dec/2010

Title: Bioadhesive nanoparticulate compositions having cationic surface stabilizers

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LTD ELAN PHARMA INTERNATIONAL, LTD

Application No.: 11/898274   Filing Date: 11/Sep/2007

Abstract:

Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

Priority: US2001-004808 Applic. Date: 2001-12-07; US1999-414159 Applic. Date: 1999-10-08

Inventor: BOSCH H WILLIAM [US]; COOPER EUGENE R [US]; MCGURK SIMON L [US]


Patent No.: US7858119B1  Issued: 28/Dec/2010

Title: Extended release pharmaceuticals

Applicant/Assignee:

Application No.: 09/845497   Filing Date: 01/May/2001

Abstract:

An extended release pharmaceutical formulation is disclosed. A selected pharmaceutical agent is encased within polymeric film layers providing for gradual release of the pharmaceutical active for over 12 and even 24 hours in the gastrointestinal tract and the blood plasma.

Priority: US20000203049P Applic. Date: 2000-05-09

Inventor: ODIDI AMINA [CA]; ODIDI ISA [CA]

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