Patents in Blood Anticlot Technology, Medications and Medical
Devices

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US GRANTED PATENTS IN BLOOD ANTICLOT DRUGS AND DEVICES PUBLISHED FROM 1980 TO 1996



Patent No.: US4190535A  Issued: 26/Feb/1980

Title: Means for separating lymphocytes and monocytes from anticoagulated blood

Applicant/Assignee: CORNING GLASS WORKS

Application No.: 922825   Filing Date: 10/Jul/1978

Abstract:

This invention relates to a method for isolating platelets, lymphocytes, and monocytes from anticoagulated blood. The method involves centrifuging at high force a sample of uncoagulated blood with a water-insoluble thixotropic gel-like material having a specific gravity between 1.065-1.077 g/cc for a length of time sufficient to cause the gel-like material to form a barrier between the platelets, lymphocytes, monocytes, and plasma fraction of the blood and the heavier blood cells. Thereafter, the plasma is withdrawn and the platelets, lymphocytes, and monocytes removed from above the barrier in a buffer solution. Where desired, the platelets can be separated from the lymphocytes and monocytes utilizing a similar process but wherein the water-insoluble thixotropic gel-like material has a specific gravity of less than about 1.055 g/cc.

Priority: US1978-881252 Applic. Date: 1978-02-27

Inventor: LUDERER ALBERT A [US]; ODSTRCHEL GERALD [US]; ZINE ANTHONY R JR [US]


Patent No.: US4193980A  Issued: 18/Mar/1980

Title: Dry preparation for reticulocyte staining

Applicant/Assignee: CORNING GLASS WORKS

Application No.: 867199   Filing Date: 05/Jan/1978

Abstract:

A dry stain for reticulocyte staining comprising a mixture of new methylene blue N dye, potassium acetate, and an anti-blood-clotting agent. The stain is prepared in a concentrated aqueous solution, filtered, dispensed volumetrically into tubes, and dried. The correct quantity of dye per tube is determined spectrophotometrically, and the proper ratio of dye to potassium acetate is determined by pH measurements. For staining reticulocytes, whole blood is added to the tube and mixed with the dry stain. Smears are then prepared on slides in a conventional manner for microscopic examination.

Priority:

Inventor: CLASON STANLEY E [US]; GILLILAND JOHN W [US]


Patent No.: US4199840A  Issued: 29/Apr/1980

Title: Scraper blade structure for meat cleaning machine

Applicant/Assignee: HOBART CORP

Application No.: 730135   Filing Date: 06/Oct/1976

Abstract:

The section modulus of elasticity of the body portions of the scraper blades in a meat scraping machine decrease substantially uniformly outwardly along each blade. The blades have flat, transversely flexible scraping edges on the ends opposite a common series of circular hubs. Each hub is slightly rotated with respect to the adjacent hub to provide a series of spiraling blade-like edges for engaging and scraping accumulated residues from the sawed surface of a piece of meat. An adjustable doctor blade removes the residue from the scraper blades. The uniformly decreasing section modulus of elasticity of each blade encourages uniform flexing along the length of each blade to distribute stresses and fatigue uniformly throughout the blade material. The blades are pre-flexed on the hubs to reduce the effective diameter of the blade structure and to reduce the flexing of the blades when encountering the meat and the doctor blade.

Priority: US1975-566366 Applic. Date: 1975-04-09

Inventor: CRANE HERBERT R [US]


Patent No.: US4203891A  Issued: 20/May/1980

Title: Method of collecting anti-hemophilic factor VIII from blood and blood plasma using heparin or sodium heparin

Applicant/Assignee:

Application No.: 865656   Filing Date: 29/Dec/1977

Abstract:

A method of greatly increasing the yield of anti-hemophilic Factor VIII (AHF) obtained from whole blood, blood plasma or plasma fractions based on the maintenance of physiological concentrations of calcium and/or other ions in the whole blood or plasma components.

Priority: CA19770293393 Applic. Date: 1977-12-19

Inventor: ROCK GAIL A [CA]


Patent No.: US4204537A  Issued: 27/May/1980

Title: Process for pheresis procedure and disposable plasma

Applicant/Assignee: HAEMONETICS CORP

Application No.: 810213   Filing Date: 27/Jun/1977

Abstract:

A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.

Priority: US1974-497558 Applic. Date: 1974-08-15

Inventor: LATHAM ALLEN JR [US]


Patent No.: US4212307A  Issued: 15/Jul/1980

Title: Blood sampling syringe

Applicant/Assignee: CONCORD LABS INC

Application No.: 868897   Filing Date: 12/Jan/1978

Abstract:

Improved disposable syringe for taking blood or other fluid samples, particularly arterial samples for blood gas testing or the like, which comprises a syringe body, a piston or plunger having a compressible end piece which forms a seal with the inner surface of the syringe body, and a means for preventing compression or deformation of the compressible end piece against the end wall of the syringe body.

Priority:

Inventor: RAITTO RUSSELL G [US]


Patent No.: US4212948A  Issued: 15/Jul/1980

Title: Apparatus for detecting microbial pathogens employing a cushioning agent

Applicant/Assignee: WADLEY, J K & SUSIE L RESEARCH INSTITUTE & BLOOD BANK

Application No.: 952339   Filing Date: 18/Oct/1978

Abstract:

A method and apparatus are disclosed which provide for improved rapid quantitative analysis of a blood sample for the presence of microbial pathogens. The blood sample is lysed and deposited on a high density, water immiscible, hydrophobic, nontoxic, liquid cushioning agent and subjected to centrifugation. Microbial pathogens contained in the lysed blood sample will collect in a layer adjacent the interface of the cushioning agent and the blood sample residue and, in this concentrated form, can easily be separated from the residual portion of the blood sample for culturing and quantitative counting.

Priority:

Inventor: DORN GORDON L [US]


Patent No.: US4214874A  Issued: 29/Jul/1980

Title: Combination and method for mixing the contents of a blood collection tube and thereafter removing the mixing element

Applicant/Assignee: AMERICAN HOSPITAL SUPPLY CORP

Application No.: 10234   Filing Date: 08/Feb/1979

Abstract:

Combination and method for mixing a blood sample and an anticoagulant within a collection tube and for then capturing, removing and discarding the mixing element without danger of direct contact between the blood sample and the technician. The full combination includes a blood collection tube, at least one resilient end cap for the tube having a cavity which extends well beyond that tube when the cap is in place, a magnetic element slidable within the tube and receivable in the cap, and a magnet for shifting the magnetic element. After being directed into the cap following a mixing operation, the blood-covered magnetic element may be held within the cavity by finger pressure on the cap and discarded along with the cap.

Priority:

Inventor: WHITE FRED K [US]


Patent No.: US4215701A  Issued: 05/Aug/1980

Title: Elastomeric plunger tip for a syringe

Applicant/Assignee: CONCORD LABORATORIES INC

Application No.: 935304   Filing Date: 21/Aug/1978

Abstract:

An elastomeric plunger tip for syringes comprises a compressible, elastomeric material having a durometer of about 35 to about 75 when measured on the Shore A scale and maintains its resilience at temperatures at least as low as 0 DEG C. The plunger tip is provided with a peripheral annular wiper lip extending axially forwardly and radially outwardly into sealing contact with the syringe barrel.

Priority:

Inventor: RAITTO RUSSELL G [US]


Patent No.: US4237883A  Issued: 09/Dec/1980

Title: Needle package and method of treating syringe

Applicant/Assignee: AMERICAN HOSPITAL SUPPLY CORP

Application No.: 26118   Filing Date: 02/Apr/1979

Abstract:

A needle package which can contain any one of various sizes of needles and can be sold independently of a hypodermic syringe. The needle package includes a conventional needle protector fitted with a hypodermic needle and a closure. Within the protector is a syringe treating liquid, such as an anticoagulant (heparin), for treating a syringe immediately prior to collecting a blood sample. The same needle used for treating the syringe is also used for collecting a blood sample after removal of the protector.

Priority:

Inventor: AKHAVI DAVID S [US]


Patent No.: US4245654A  Issued: 20/Jan/1981

Title: Blood sampling syringe

Applicant/Assignee: CONCORD LABORATORIES, INC

Application No.: 780123   Filing Date: 22/Mar/1977

Abstract:

Improved disposable syringe for taking blood or other fluid samples, particularly arterial samples for blood gas testing or the like, which comprises a syringe body, a piston or plunger having a compressible end piece which forms a seal with the inner surface of the syringe body, the syringe body having a non-tapered section through which the end piece moves during withdrawal of the piston and preferably means for resisting further movement of the end piece when the desired sample size has been obtained. Also preferably the syringe has means which prevent contact between the compressible end piece and the end wall of the syringe.

Priority:

Inventor: RAITTO RUSSELL G


Patent No.: US4250872A  Issued: 17/Feb/1981

Title: Blood pulsating and/or pumping device

Applicant/Assignee:

Application No.: 909567   Filing Date: 25/May/1978

Abstract:

A continuous length of flexible polymeric tubing having a smooth fissureless inner surface throughout is provided with a region intermediate its ends which region has an inside diameter greater than the inside diameter of the remainder of said tubing and a thinner wall than that of the remainder of said tubing with a gradual transition in wall thickness and diameter therebetween. A rigid walled enclosure surrounds said region of the tubing with a slight clearance therebetween except at the ends of the enclosure which encircle the tubing beyond said region with a snug fit. A duct is joined to the enclosure near one end for feeding fluid under pressure thereto. Various arrangements of over-pressure relief prevent pinching of the tubing while affording controlled indentation thereof. The transition section of the tubing wall can cooperate with a port in the enclosure to afford said overpressure relief. Portions of the tubing wall may be thickened (i.e., strengthened) or attached to the enclosure to limit indentation.

Priority:

Inventor: TAMARI YEHUDA


Patent No.: US4258723A  Issued: 31/Mar/1981

Title: Biological/pharmaceutical fluid collection and mixing system and method

Applicant/Assignee: SBR LAB, INC

Application No.: 928411   Filing Date: 01/Aug/1978

Abstract:

Blood collection apparatus, systems and methods for minimizing the lesion of collection caused by initial high volume ratios of anticoagulant fluid to blood at the beginning of known collection processes in which blood is passed into a collection bag containing the total amount of anticoagulant fluid for the entire amount of blood to be collected. A collection bag system has a bag containing the anticoagulant fluid which is passed to a blood collection bag at a rate determined by the flow rate of the blood into the collection bag to maintain the ratio of anticoagulant to blood at a level to minimize the lesion of collection throughout the collection process. The blood collection bag is suspended by a spring from a blood bag stand and the anticoagulant bag is supported by the stand in a fixed position. The bags are arranged on the stand and interconnected so that flow rate of anticoagulant is dependent upon the difference in levels of the blood and anticoagulant mixture in the collection bag and the anticoagulant in the anticoagulant bag. The collection bag is suspended from the stand by a spring to gradually lower the collection bag during the collection process and thereby maintain the difference between the levels at a desired value. In one embodiment, provision is made for mixing the blood and anticoagulant in a tube immediately prior to passing the mixture into the collection bag.

Priority:

Inventor: MCCUE JOHN P; BRAMSON MOGENS L


Patent No.: US4267837A  Issued: 19/May/1981

Title: Blood collection monitoring device and method

Applicant/Assignee: SBR LAB INC

Application No.: 79487   Filing Date: 27/Sep/1979

Abstract:

This invention is directed to apparatus and a method for monitoring the collection of blood from a donor so as to minimize trauma to the blood so collected. The system closely monitors the rate of collection of blood and regulates the rate of mixing of anticoagulant therewith so as to maintain a substantially constant ratio of anticoagulant to blood throughout the collection process. The system also includes built-in warning devices for indicating when the collection process is not proceeding according to a prescribed pattern.

Priority:

Inventor: PURDY ROBERT W; ARNESON DON A


Patent No.: US4271122A  Issued: 02/Jun/1981

Title: Control plasma

Applicant/Assignee: HOFFMANN-LA ROCHE INC

Application No.: 31657   Filing Date: 19/Apr/1979

Abstract:

Control plasma of non-human origin to be utilized in the monitoring of oral anticoagulant therapy in human beings, prepared from blood of stable anticoagulated mammals, is described.

Priority: CH19780004582 Applic. Date: 1978-04-27

Inventor: STRAESSLE RUDOLF; ZAUGG HANS


Patent No.: US4276140A  Issued: 30/Jun/1981

Title: Electrodialysis apparatus and process for fractionating protein mixtures

Applicant/Assignee: IONICS INC

Application No.: 111144   Filing Date: 10/Jan/1980

Abstract:

Apparatus and process for the fractionation of liquid solutions of protein mixtures which includes the steps of subjecting such solutions to electrodialysis (ED) while in the pH range of about between 5-8 until a partial or a substantially complete desalting takes place, the ED preferably being conducted between about 15 DEG C. to 40 DEG C., separating the fraction of protein which precipitates, passing the resulting supernatant salt depleted protein mixture into the concentrating compartments of the ED apparatus whereby the salts entering the salt concentrating chambers from the adjacent salt diluting chambers will substantially restore the original salt content of the desalted protein mixture.

Priority:

Inventor: JAIN SURENDAR M


Patent No.: US4276172A  Issued: 30/Jun/1981

Title: Cellulosic membrane for blood dialysis

Applicant/Assignee: AKZO N.V

Application No.: 875926   Filing Date: 07/Feb/1978

Abstract:

A multilayer cellulosic membrane for blood dialysis and a method for the production of said membrane by regeneration from separately extruded cuprammonium cellulose solutions brought together to form two or more permanently adhered layers, each layer forming a seal against blood penetration through the leakage points of an adjacent layer, the resulting multilayer membrane thus being substantially free of blood leakage over the total thickness of the membrane. Especially preferred membranes for blood dialysis are those in which the layer arranged on the blood side of the diaphragm contains a modified cellulose chemically bound with an antithrombogenic substance.

Priority: DE19772705733 Applic. Date: 1977-02-11; DE19772705735 Applic. Date: 1977-02-11

Inventor: HENNE WERNER; DUENWEG GUSTAV


Patent No.: US4280496A  Issued: 28/Jul/1981

Title: Phlebotomy needle assembly

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 12825   Filing Date: 16/Feb/1979

Abstract:

A phlebotomy needle assembly is provided which permits an anticoagulant to be mixed with whole blood immediately adjacent the cannula through which the whole blood is drawn, to prevent coagulation. A blood-anticoagulant mixing device has a blood inlet for coupling to the cannula, an anticoagulant solution inlet for coupling to a source of anticoagulant and a blood-anticoagulant mixture outlet for coupling to outlet tubing. The blood inlet and the anticoagulant inlet are generally coaxial and the mixture outlet is axially offset with respect to the inlets. The blood inlet defines a mixing chamber and a passage communicates with the mixing chamber and the mixing outlet for providing an outlet flow path through the mixing device for the blood-anticoagulant mixture.

Priority:

Inventor: VAN BAELEN ARMAND R


Patent No.: US4289691A  Issued: 15/Sep/1981

Title: Method of obtaining intermediate purity factor VIII

Applicant/Assignee: THE CANADIAN RED CROSS SOCIETY

Application No.: 210385   Filing Date: 26/Nov/1980

Abstract:

A method of obtaining Factor VIII which comprises (a) adding heparin to freshly obtained blood plasma collected into a calcium chelating anticoagulant or collecting blood plasma by plasma pheresis using heparin and a calcium chelating anticoagulant

(b) freezing the plasma

(c) resolubilizing the plasma

(d) isolating a cryoprecipitate from the plasma

(e) resolubilizing the cryoprecipiate

(f) adding a citrate saline heparin buffer to the resolubilized cryoprecipitate

(g) incubating the buffered, resolubilized cryoprecipitate at a temperature of from about 0 DEG to about 10 DEG C. for a time in excess of about one hour, whereby Factor VIII present in the cryoprecipitate is insolubilized using heparin precipitable cold insoluble globulin and the resulting Factor VIII rich precipitate also includes cold insoluble globulin

(h) separating the Factor VIII rich precipitate

and (i) isolating Factor VIII therefrom. The introduction of the cold insoluble globulin (CIg) step to Factor VIII production results in markedly increased yields of Factor VIII in the cryoprecipitate and, as well, in the cold-insoluble globulin obtained from the cryoprecipitate. Using this procedure, 81% of the Factor VIII is recovered in the cryoprecipitate. The cold-insoluble globulin contains 62% of the starting Factor VIII activity. A final recovery of 666 units per liter of starting plasma is therefore obtained and the amount of protein is reduced to less than 1%. In addition, the procedure can be carried out in blood donor centers, although it is also envisaged to be useful in larger scale recovery of Factor VIII procedures.

Priority: CA19800344000 Applic. Date: 1980-01-18

Inventor: ROCK GAIL A; PALMER DOUGLAS S


Patent No.: US4293576A  Issued: 06/Oct/1981

Title: Food product and process of manufacture

Applicant/Assignee: EFFEM FOODS PTY. LTD

Application No.: 932650   Filing Date: 10/Aug/1978

Abstract:

The invention relates to an improved food product for animals and a process for producing such a product. The product and process are based on whole animal blood, and/or coagulable phase(s) of such blood, which is (are) subjected to controlled stimulated coagulation.

Priority: AU1977PD01233 Applic. Date: 1977-08-15

Inventor: SENTANCE CHRISTOPHER B


Patent No.: US4294833A  Issued: 13/Oct/1981

Title: Substituted 4-hydroxy-isophthalic acid picolylamides having a pharmaceutical activity in thromboembolic disorders

Applicant/Assignee: MANETTI & ROBERTS ITALO BRIT

Application No.: 937732   Filing Date: 29/Aug/1978

Abstract:

There are prepared 4-hydroxy-isophthalic acid bis (3- or 4-picolyl-amides) of the formula (I) where R' is H or an aliphatic or alicyclic hydrocarbon group with 1 to 16 carbon atoms, R'''' is 3-pyridyl or 4-pyridyl, R''' is H, Cl, NO2, or -OCH3, R'' is an aliphatic or alicyclic hydrocarbon group with 1 to 8 carbon atoms with the exception that when R'''' is 3-pyridyl and R' and R''' are both H, then R'' is an aliphatic or alicyclic hydrocarbon radical with 3 to 8 carbon atoms. The compounds are useful in inhibition of blood platelet aggregation.

Priority: IT19770050896 Applic. Date: 1977-09-06

Inventor: INNOCENTI FRANCO; ORZALESI GIOVANNI; VOLPATO IVO


Patent No.: US4301153A  Issued: 17/Nov/1981

Title: Heparin preparation

Applicant/Assignee: RIKER LABORATORIES, INC

Application No.: 891706   Filing Date: 30/Mar/1978

Abstract:

A heparin preparation which exhibits elevated anticoagulant activity and a process for producing the preparation. Conventional heparin exhibiting characteristic anticoagulant activity and molecular heterogeneity is incubated with antithrombin-heparin cofactor extracted from plasma. A portion of the heparin forms a complex with the cofactor. The uncomplexed heparin fraction is then separated from the complexed fraction, and the complexed fraction is broken down to produce cofactor and an active form of heparin.

Priority: US1977-779691 Applic. Date: 1977-03-21

Inventor: ROSENBERG ROBERT D


Patent No.: US4304672A  Issued: 08/Dec/1981

Title: Stored blood and liquid system pH control method and apparatus

Applicant/Assignee: SBR LAB, INC

Application No.: 892371   Filing Date: 04/Apr/1978

Abstract:

Method and apparatus for continuous pH control of aqueous liquid systems, particularly biological and biochemical systems such as stored blood, by sorption of H+ andwith a passive ion acceptor material isolated from, but in contact with liquid of said system in a selectively permeable membrane packet. Liquid systems of interest are those with an initial pH in the range of from about 4.5 to 9.0, and the pH of the system is maintained by the invention at its initial value, or brought within, and maintained in, the range of from about 6.5 to 8.0. The ion acceptor material is selected from an inorganic, relatively water insoluble metal oxide, hydroxide, phosphate or silicate matrix, which matrix is capable of maintaining a quasi-equilibrium pH state with the aqueous liquid system. The matrixing metals are preferably selected from Ti, Al and B. The matrices may be doped with oxides or hydroxides of Mg, Ca, Zn, Fe, Cu, Co, Cr and V to permit predetermined selection of a desired quasi-equilibrium pH value, and to adjust effective base capacity. Cation (e.g., Na+ and K+) doping may be used to expand the matrix lattice structure and help maintain electric (ionic) neutrality. Typical matrix acceptor compounds are selected from Al2O3, anhydrous Al(OH)3, Al(OH)3 gel (preferred), MgHPO4, and Mg2Si3O8.

Priority:

Inventor: MCCUE JOHN P


Patent No.: US4311151A  Issued: 19/Jan/1982

Title: Oxygen measuring electrode assembly

Applicant/Assignee:

Application No.: 85397   Filing Date: 16/Oct/1979

Abstract:

A polarographic electrode assembly for transcutaneous measurement of partial oxygen pressure in arterial blood comprising an anode, a cathode which has a thin ring surface or a circularly-bounded field of dot-shaped surfaces and an insulating electrode holder, a disposable tubular member holder fixedly holding the periphery of an oxygen permeable hydrophobic electrode membrane, and a skin-heating part including heat-conducting block which is thermally connected to a heater and a temperature detector. The heat-conducting block has a thick peripheral portion and thin disk-shaped inner portion having a through-hole to expose the cathode surface to the subject's skin via the membrane. One side of the heat-conducting block has a smooth surface to be applied on skin, and the back side has a receiving space for the membrane holder. The heat-conducting block embraces the membrane holder which embraces the anode and cathode portion of the electrode part in such a manner that the membrane covers the working surfaces of the anode and cathode via an electrolyte layer. In a prefabrication step the membrane is strongly bonded in a uniformly stretched condition to the holder for stability of sensitivity of the electrode. By using such a cathode a good correlation coefficient of measured PO2 over actual arterial PO2 and a good S/N ratio are provided, and by using a skin heating block having a sufficient heating area a highly stable electrode sensitivity is assured.

Priority: JP19770101235 Applic. Date: 1977-08-24; JP19770126988 Applic. Date: 1977-10-22

Inventor: HAGIHARA BUNJI


Patent No.: US4311482A  Issued: 19/Jan/1982

Title: Method and apparatus for collecting blood samples

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 82840   Filing Date: 09/Oct/1979

Abstract:

This invention encompasses methods and apparatus for collecting blood samples. It has been discovered that p-aminobenzoyldiethylaminoethanol (procaine) is unexpectedly potent in stabilizing blood samples against platelet release reactions. Methods and apparatus of this invention are particularly useful for collecting blood samples for subsequent platelet factor 4 determination.

Priority:

Inventor: WORKMAN JR ERWIN F; CLARK DEBORAH M


Patent No.: US4311789A  Issued: 19/Jan/1982

Title: Method for sampling and measuring the content of a low-molecular weight compound in a complex fluid medium

Applicant/Assignee: GAMBRO AG

Application No.: 69698   Filing Date: 27/Aug/1979

Abstract:

A method is provided for sampling and measuring the content of a low-molecular weight compound, such as glucose, cholesterol, or urea, in a complex fluid medium to be sampled, such as blood. A dialyzer is placed in contact with the complex fluid medium so that it passes through the dialyzer. One or more semipermeable membranes are disposed within the complex fluid medium to form one or more passageways for the passage of dialysis fluid, with the passageways being substantially smaller in volume than the volume of the surrounding complex fluid medium. A fractional portion of the complex fluid medium is acted on by the dialysis fluid and dialyzed so that only a fractional portion of the low-molecular weight compound diffuses into the passageways containing the dialysis fluid to produce a dialysate in the passageways. The dialysate is then measured to determine the content of the low-molecular weight compound in the complex fluid medium.

Priority: SE19760000024 Applic. Date: 1975-12-31; US1976-755977 Applic. Date: 1976-12-30

Inventor: NYLEN ULF T G; QVARNSTROM LARS A G


Patent No.: US4314025A  Issued: 02/Feb/1982

Title: Blood preservation anticoagulant solution

Applicant/Assignee: SBR LAB, INC

Application No.: 51697   Filing Date: 25/Jun/1979

Abstract:

Method and apparatus for continuous pH control of aqueous liquid systems, particularly biological and biochemical systems, by sorption of H+ and/or OH- ions with a passive ion acceptor material isolated from, but in contact with liquid of said system in a selectively permeable membrane packet. Liquid systems of interest are those with an initial pH in the range of from about 4.5 to 9.0, and the pH of the system is maintained by the invention at its initial value, or brought within, and maintained in, the range of from about 6.5 to 8.0. The ion acceptor material is selected from an inorganic, relatively water insoluble metal oxide, hydroxide, phosphate or silicate matrix which matrix is capable of maintaining a quasi-equilibrium pH state with the aqueous liquid system of interest. The matrixing metals are preferably selected from Ti, Al and B. The matrices may be doped with oxides or hydroxides of Mg, Ca, Zn, Fe, Cu, Co, Cr and V to permit predetermined selection of a desired quasi-equilibrium pH value, and to adjust effective base capacity. Cation (e.g., Na+ and K+) doping may be used to expand the matrix lattice structure and help maintain electric (ionic) neutrality. Typical matrix acceptor compounds are selected from Al2O3, anhydrous Al(OH)3, Al(OH)3 gel (preferred), MgHPO4, and Mg2Si3O8. Depending on the materials and dopants used, the matrix acceptors can act either as a weak base or a weak acid. Most importantly the ability of the invention to maintain the pH of surrounding aqueous systems between 6.5 and 8.0 in a non-toxic, non-interfering fashion fills a gap in the present state of the art by achieving effective "buffering" in a range often unobtainable suitably by any other means. The matrix acceptor materials can maintain their initial state even after absorbing up to one-third their stoichiometric equivalent of H+ and/or OH- ion. The hydrogen acceptor, e.g., in packet form, is also useful for continuous H+ or OH- sorption and pH control for other liquid systems, such as organic and inorganic reactions, fermentation processes, enzymatic reactions, organ storage, and tissue and culture growth, MgCl2 added to the hydrogen acceptor packet unit further improves blood preservation during storage. New blood anticoagulant Mg+2 ion containing solutions are disclosed.

Priority: US1978-892371 Applic. Date: 1978-04-04

Inventor: MCCUE JOHN P


Patent No.: US4324236A  Issued: 13/Apr/1982

Title: Fitting for use in performing a vascular puncture

Applicant/Assignee: WHITMAN MEDICAL CORP

Application No.: 99926   Filing Date: 03/Dec/1979

Abstract:

A fitting for use in performing a vascular puncture includes a system for rapidly and securely stabilizing an intravascular catheter or needle to a patient's skin upon insertion of the needle or catheter into a blood vessel. The hub of the needle or catheter has upper and lower lateral wings extending from its opposite sides. The wings are folded up over the hub and gripped together while a vascular puncture is made and then the lower wings, which have adhesive under surfaces, are released and dabbed onto the skin to rapidly stabilize the fitting. The upper wings can be taped down over the lower wings to effect a more permanent attachment of the fitting.

Priority:

Inventor: GORDON MARVIN; LICHTENSTEIN JOSEPH


Patent No.: US4327722A  Issued: 04/May/1982

Title: Methods and apparatus for intravenous therapy and hyperalimentation

Applicant/Assignee:

Application No.: 67753   Filing Date: 20/Aug/1979

Abstract:

Methods and apparatus for short term and long term intravenous therapy including hyperalimentation are disclosed. The proximal end of a flexible catheter having a one way valve adjacent its proximal end is inserted through the skin of a patient and into a vein having a suitably large flow of blood therethrough. The distal end of the catheter has a threaded male coupler for connecting it to a flow reducing adaptor and then to a source of intravenous solution. The solution flows by gravity through the catheter and into the vein. A passer which can be connected to the male coupler is provided for subcutaneously threading the catheter during long term catheter placement.

Priority:

Inventor: GROSHONG LEROY E; BRAWN RONALD J


Patent No.: US4330622A  Issued: 18/May/1982

Title: Elimination of non-microbial turbidity in culture media

Applicant/Assignee: BECTON DICKINSON & CO

Application No.: 75158   Filing Date: 12/Sep/1979

Abstract:

In the culturing of micro-organisms, non-microbial turbidity in the supernate is prevented by including an adsorbant for components which cause such non-microbial turbidity

e.g., lipoproteins and/or chylomicrons, with such adsorbant being soluble in the culture media. The adsorbant sediments such components, and is particularly effective in culture media which include an anticoagulant. Carboxy Methyl Cellulose is a particularly effective adsorbant.

Priority:

Inventor: DESAI JAY S


Patent No.: US4340565A  Issued: 20/Jul/1982

Title: Hematocrit value determining element

Applicant/Assignee: FUJI PHOTO FILM CO., LTD

Application No.: 221183   Filing Date: 29/Dec/1980

Abstract:

A hematocrit value determining element comprising, in one embodiment, a water-impermeable planar support having integrally provided thereon a hydrophilic porous spreading layer, the porous spreading layer being such that blood spreads therethrough depending upon the viscosity of the blood and, in a second embodiment, a hematocrit value determining element as described above and a binder layer provided between the planar support and the porous spreading layer.

Priority: JP19790173624 Applic. Date: 1979-12-28

Inventor: KITAJIMA MASAO; ARAI FUMINORI; KONDO ASAJI


Patent No.: US4342740A  Issued: 03/Aug/1982

Title: Method and kit for labeling red blood cells with technetium-99m

Applicant/Assignee: E. R. SQUIBB & SONS, INC

Application No.: 179306   Filing Date: 18/Aug/1980

Abstract:

The labeling of red blood cells with technetium-99m using a stannous reducing agent is facilitated by the addition of an oxidizing agent along with the radioactive pertechnetate ion.

Priority:

Inventor: NARRA RAMA K; KUCZYNSKI BRUCE L


Patent No.: US4359463A  Issued: 16/Nov/1982

Title: Stabilization of Factor VIII activity in whole blood or blood plasma

Applicant/Assignee:

Application No.: 210383   Filing Date: 26/Nov/1980

Abstract:

A method whereby initial Factor VIII activity normally present in blood collected into an anticoagulant which functions by chelating calcium is maintained for twenty-four or more hours without the necessity of the usual immediate freezing in either the whole blood or blood plasma. The method comprises mixing freshly collected blood or blood plasma prepared from that blood or freshly obtained blood plasma obtained by plasmapheresis, which blood or blood plasma has been collected into a calcium chelating anticoagulant, with a calcium-heparin solution in sufficient quantities to restore calcium to substantially normal physiological levels.

Priority:

Inventor: ROCK GAIL A


Patent No.: US4363329A  Issued: 14/Dec/1982

Title: Syringe having a reverse-taper barrel

Applicant/Assignee: CONCORD LABORATORIES, INC

Application No.: 885496   Filing Date: 13/Mar/1978

Abstract:

An improved disposable syringe for taking arterial blood samples for blood gas testing, and the like, wherein the syringe barrel has a reverse-taper section at the forward end thereof so that, in such section, the inner diameter of the barrel is progressively larger the closer it is to the forward end of the barrel. Preferably, the syringe plunger has a compressible elastomeric tip member which has a peripheral annular wiper that extends axially toward the forward end of the syringe and radially outwardly at an acute angle to the longitudinal center line of the barrel and plunger to form an excellent seal with the inner surface of the syringe barrel while at the same time providing only a gentle pressure against such surface and hence an exceptionally low resistance to axial movement of the tip member and plunger. The syringe, preferably, also has means for preventing further forward movement of the plunger so that, when the plunger tip is moved forward to eject air and excess liquid anti-coagulant, a predetermined amount of the anti-coagulant remains in a space of predetermined volume between the plunger tip and the forward end of the syringe barrel.

Priority:

Inventor: RAITTO RUSSELL G


Patent No.: US4368124A  Issued: 11/Jan/1983

Title: Method of winding a mass transfer device and product

Applicant/Assignee:

Application No.: 221999   Filing Date: 02/Jan/1981

Abstract:

A mass transfer device of the type used, e.g., for blood dialysis is made by winding on a mandrel a series of fiber strands, each of which consists of a solid fiber and one or more hollow fibers, the solid fiber being at least as large, and preferably substantially larger, in diameter than the hollow fiber. As the strands are wound on the mandrel they are temporarily anchored at spaced locations along the mandrel by beads of a liquid pre-potting compound which eventually harden into said anchor plates. When the winding is complete, the mandrel is cut at each anchor plate to form individual temporary cartridges which can withstand the handling required in washing and drying. After each individual cartridge is final-potted, the anchor plates are discarded, and the final potting is cut in a conventional manner to form manifold surfaces at each end of the cartridge. A deburring treatment is then applied to the manifold surface at each end of the cartridge to smooth out any microscopic irregularities of the manifold surface which can cause thrombogenesis.

Priority: US1979-028238 Applic. Date: 1979-04-09

Inventor: BRUMFIELD ROBERT C [US]


Patent No.: US4375466A  Issued: 01/Mar/1983

Title: Method of determining and treating affective illness

Applicant/Assignee:

Application No.: 139706   Filing Date: 14/Apr/1980

Abstract:

A method of determining affective illness (i.e. mood disorders) involves serological testing. The serotonin uptake of the patient's blood platelets is determined and compared with a standard blood platelet serotonin uptake characteristic of a particular type of affective illness to determine the patient's type of affective illness. A method of treating a patient having a particular affective illness is provided which includes treating the patient with an effective amount of at least one drug which is effective in treating persons having the same blood platelet serotonin uptake as the patient.

Priority:

Inventor: LEUSCHNER JANET [US]


Patent No.: US4381776A  Issued: 03/May/1983

Title: Anticoagulant dispensing apparatus and method of use

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 254078   Filing Date: 14/Apr/1981

Abstract:

An aseptically pure dispensing anticoagulant device adapted to be connected to a blood collection set and which may be aseptically treated by ethylene oxide or other high diffusivity sterilant without deleterious effects upon the anticoagulant. Various embodiments are shown

in one, a collapsible pouch is provided which includes a barrier against diffusion of water vapor and ethylene oxide. In another embodiment, a rigid anticoagulant container is employed which necessitates a secondary volume of air in a surrounding pouch to provide air to displace liquid in the rigid container as it passes into the set.

Priority: US1980-161285 Applic. Date: 1980-06-20

Inventor: LATHAM JR ALLEN


Patent No.: US4383989A  Issued: 17/May/1983

Title: Factor VIII concentrates prepared from heparinized plasma by the application of a cold precipitation technique

Applicant/Assignee:

Application No.: 317312   Filing Date: 02/Nov/1981

Abstract:

A method for recovering Antihemophilic Factor VIII from whole blood or blood plasma or blood plasma fractions freshly collected directly into an anticoagulant selected from the group of heparin, sodium heparin, or mixtures thereof, the heparin being used in the range of 6-8 units/ml of plasma or 3.5-4 units/ml of blood

and either first separating the red cells from the plasma and/or freezing the heparinized plasma, resolubilizing the plasma, isolating a cryoprecipitate from the plasma, resolubilizing the cryoprecipitate, adding a saline heparin solution to the resolubilized cryoprecipitate, incubating the resolubilized cryoprecipitate at a temperature of from about 0 DEG C. to about 4 DEG C. for a time of at least 2 hours, whereby Factor VIII present in the cryoprecipitate is insolubilized using heparin precipitable cold insoluble globulin and the resulting Factor VIII rich precipitate also includes cold insoluble globulin, separating the Factor VIII rich precipitate, and isolating Factor VIII therefrom. This new process permits recovery of a high purity Factor VIII preparation which can easily be made in the blood bank or alternatively, the cold precipitation step can be carried out in a fractionation plant.

Priority: CA19810387063 Applic. Date: 1981-10-01

Inventor: ROCK GAIL A [CA]


Patent No.: US4385630A  Issued: 31/May/1983

Title: Blood donation unit

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 182510   Filing Date: 29/Aug/1980

Abstract:

A blood donation unit in which a reduced outside diameter phlebotomy needle is employed to minimize donor discomfort. The blood flow if, however, maintained at a flow level similar to that obtained with standard gauge phlebotomy needles by a roller pump which provides a predetermined pressure differential between the ends of the phlebotomy needle. The blood is mixed with a predetermined ratio of anticoagulant immediately after passing through the phlebotomy needle. The ratio of whole blood to anticoagulant is independent of the volume of whole blood collected.

Priority:

Inventor: GILCHER RONALD O; LATHAM JR ALLEN; SCHIFF JONATHAN D; SCHOENDORFER DONALD W


Patent No.: US4386069A  Issued: 31/May/1983

Title: Additive solution and method for preserving normal red cell morphology in whole blood during storage

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 326771   Filing Date: 02/Dec/1981

Abstract:

An additive solution, which can be dispersed in whole blood to enhance preservation of normal red cell morphology during storage, comprises a fatty ester which includes at least two ester linkages comprising fatty hydrocarbon groups of about four to twelve carbon atoms each. The solution can be introduced into the whole blood either at the outset of the storage period or any time during the period in an amount to provide, after its introduction, a concentration of the fatty ester of between 150 and 3,000 micrograms per milliliter of whole blood. When introduced at the outset of storage, morphological changes in the red cells are significantly retarded during the storage period. When introduced at later stages of storage, the solution serves to rejuvenate a significant percentage of red cells which have undergone morphological changes prior to the introduction of the solution.

Priority:

Inventor: ESTEP TIMOTHY N


Patent No.: US4400397A  Issued: 23/Aug/1983

Title: Antithrombotic treatment with quaternary ammonium sulfites and bisulfites

Applicant/Assignee: T & R CHEMICALS, INC

Application No.: 337121   Filing Date: 05/Jan/1982

Abstract:

Certain quaternary ammonium sulfites and bisulfites display anticoagulant and antithrombotic activity.

Priority: US1981-271848 Applic. Date: 1981-06-16

Inventor: ARIAS ALVAREZ JOSE A [MX]; THOMPSON RALPH B [US]


Patent No.: US4401654A  Issued: 30/Aug/1983

Title: Anticoagulant methods with sulfur dioxide

Applicant/Assignee: T & R CHEMICALS, INC

Application No.: 281951   Filing Date: 09/Jul/1981

Abstract:

Solutions of sulfur dioxide are found to demonstrate anticoagulant and antithrombotic activity when used in pharmaceutically effective amounts.

Priority: US1980-164304 Applic. Date: 1980-06-30

Inventor: ALVAREZ JOSE A A [MX]


Patent No.: US4401655A  Issued: 30/Aug/1983

Title: Antithrombotic treatment with salts of sulfites and bisulfites

Applicant/Assignee: T & R CHEMICALS, INC

Application No.: 337176   Filing Date: 05/Jan/1982

Abstract:

Certain inorganic salts of sulfurous acid display anticoagulant and antithrombotic activity.

Priority: US1981-271850 Applic. Date: 1981-06-16

Inventor: ALVAREZ JOSE A A [MX]


Patent No.: US4401758A  Issued: 30/Aug/1983

Title: Process for making oligosaccharides having anti-Xa activity and the resulting oligosaccharides

Applicant/Assignee: CHOAY S.A

Application No.: 194544   Filing Date: 06/Oct/1980

Abstract:exchange-document system="ops.epo.org" family-id="27516394" country="US" doc-number="4401758" kind="A"> US 4401758 A 19830830 US4401758 19830830 US19800194544 19801006 194544 GB19790034673 19791005 GB19800000443 19800107 GB19800021749 19800702 GB19800021750 19800702 GB19800029697 19800915 91,164 7934673 8000443 8021749 8021750 8029697 CHOAY SA [FR] CHOAY S.A LORMEAU JEAN-CLAUDE [FR] CHOAY JEAN [FR] PETITOU MAURICE [FR] LORMEAU, JEAN-CLAUDE, CHOAY, JEAN, PETITOU, MAURICE Process for making oligosaccharides having anti-Xa activity and the resulting oligosaccharides

Priority: GB19790034673 Applic. Date: 1979-10-05; GB19800000443 Applic. Date: 1980-01-07; GB19800021749 Applic. Date: 1980-07-02; GB19800021750 Applic. Date: 1980-07-02; GB19800029697 Applic. Date: 1980-09-15

Inventor: LORMEAU JEAN-CLAUDE [FR]; CHOAY JEAN [FR]; PETITOU MAURICE [FR]


Patent No.: US4406886A  Issued: 27/Sep/1983

Title: Purification of antihemophilia factor VIII by precipitation with zinc ions

Applicant/Assignee: UNIVERSITY PATENTS, INC

Application No.: 458128   Filing Date: 14/Jan/1983

Abstract:

The present invention relates to the reduction of the fibrinogen concentration in cryoprecipitate fraction formed during the fractionation of blood. This zinc-mediated decrease of fibrinogen increases the ratio of Factor VIII to total protein content.

Priority:

Inventor: BIER MILAN [US]; FOSTER PETER R [GB]


Patent No.: US4407291A  Issued: 04/Oct/1983

Title: Transcutaneous blood oxygen measuring device

Applicant/Assignee: SUMITOMO ELECTRIC INDUSTRIES LTD

Application No.: 176033   Filing Date: 07/Aug/1980

Abstract:

A transcutaneous blood oxygen measuring device is disclosed for the noninvasive measurement of oxygen partial pressure in arterial blood which includes a cathode surrounded by an anode held together by an insulating plastic in an electrode part, a heating portion to heat the skin of a subject to which the device is applied and to receive the electrodes plus an electrolyte. The heating portion has an opening to indirectly expose the electrodes, via an electrolyte and associated membrane, to the subject's skin surface. Adjacent the working surfaces of each electrode an electrolyte is provided, retained by an oxygen permeable membrane which, in turn, is brought into contact with the subject's skin. The working face of one electrode, typically the cathode, is extended beyond the plane of the working face of the other electrode

the opening in the heater is smoothly rounded and the cathode plus tapered hole, both having approximately the same cross-sectional area, are placed in close proximity with each other.

Priority: JP19780063373U Applic. Date: 1978-05-12

Inventor: HAGIHARA BUNJI [JP]; FUKAI TAMOTSU [JP]; NOMURA KIKUO [JP]; YOSHIDA KENICHI [JP]; ISSHIKI ISAO [JP]


Patent No.: US4415559A  Issued: 15/Nov/1983

Title: Anticoagulant

Applicant/Assignee: EISAI CO., LTD

Application No.: 345834   Filing Date: 04/Feb/1982

Abstract:

An anticoagulant containing heparin having low antithrombin III affinity as an effective ingredient.

Priority: JP19810017994 Applic. Date: 1981-02-12

Inventor: SUZUKI SUGURU [JP]; SANO NORITOSHI [JP]; TAJIMA TETSUYA [JP]


Patent No.: US4416291A  Issued: 22/Nov/1983

Title: Multiple sample needle assembly with vein entry indicator

Applicant/Assignee: BECTON DICKINSON AND COMPANY

Application No.: 284894   Filing Date: 20/Jul/1981

Abstract:

A multiple sample needle assembly useful in collecting liquid samples from a source comprises a housing with a chamber therein. A first cannula is in fluid communication with the chamber and is adapted for insertion into a liquid source. A second cannula is also in fluid communication with the chamber and is adapted to deliver liquid passing through the chamber to a liquid collector. A gas-permeable, liquid-impermeable porous member is positioned in the lumen of the second cannula. The second cannula preferably includes at least one side hole and an operable valve for collecting liquid from the second cannula by diverting liquid flowing therethrough away from the liquid-impermeable member.

Priority:

Inventor: KAUFMAN JOSEPH [US]


Patent No.: US4425114A  Issued: 10/Jan/1984

Title: Blood donation unit

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 256694   Filing Date: 23/Apr/1981

Abstract:

A blood donation unit in which a phlebotomy needle is coupled on one conduit to a source of anticoagulant contained in a flexible bag and on another conduit to a flexible collection bag. The anticoagulant bag and collection bag are placed in a chamber within which a vacuum is created, preferably by a hand pump operated by the donor. A rigid plate is disposed between the two bags. The blood flow from the donor is maintained at an adaquate flow level by the donor's pumping which provides a pressure differential between the bags and the needle. The whole blood is mixed with anticoagulant immediately after passing through the phlebotomy needle. The ratio of whole blood to anticoagulant is independent of the volume of whole blood collected and is fixed by the ratio of the surface areas of opposing bag surfaces at the interface with the plate.

Priority:

Inventor: SCHOENDORFER DONALD W [US]; LUEPTOW RICHARD M [US]; SCHIFF JONATHAN D [US]


Patent No.: US4432750A  Issued: 21/Feb/1984

Title: Additive sterol solution and method for preserving normal red cell morphology in whole blood during storage

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 326772   Filing Date: 02/Dec/1981

Abstract:

An additive solution is used to preserve normal red blood cell morphology during storage. The solution comprises a concentration of a nontoxic, physiologically compatible sterol, such as cholesterol, epi-cholesterol, lanosterol, stigmasterol, ergosterol, desmosterol, fucosterol, cholestanol, epi-cholestanol, coprosterol, epi-coprosterol, lathosterol, or campesterol. The sterol is present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood.

Priority:

Inventor: ESTEP TIMOTHY N [US]


Patent No.: US4438209A  Issued: 20/Mar/1984

Title: Radioimmunoassay for fibrinopeptide A

Applicant/Assignee: MALLINCKRODT, INC

Application No.: 284152   Filing Date: 17/Jul/1981

Abstract:

Radioimunoassay methods for determining the concentration of fibrinopeptide A in plasma, anticoagulation reagents for use in such methods and package test kits containing the reagents for use in such methods are provided.

Priority:

Inventor: MOSIER LARRY D [US]


Patent No.: US4443220A  Issued: 17/Apr/1984

Title: Blood collection and transfer apparatus

Applicant/Assignee:

Application No.: 358622   Filing Date: 16/Mar/1982

Abstract:

Blood collection and transfer apparatus is adapted for autotransfusion in preoperative, operative and postoperative procedures. A collapsible bag is provided with a stent adapted to hold it in distended form when desired, whereby a negative gage pressure may be applied for blood collection. Fittings for controlled addition of anticoagulants may be included. The apparatus is useful in diverse settings, for example, chest trauma, postsurgical collection and reinfusion of mediastinal blood, collection and reinfusion of shed blood during surgery, cell washing procedures and cardiopulmonary procedure wherein it functions as a cardiotomy reservoir.

Priority:

Inventor: HAUER JEROME M [US]; THURER ROBERT L [US]


Patent No.: US4447415A  Issued: 08/May/1984

Title: Plasma-free medium for platelet storage

Applicant/Assignee:

Application No.: 449762   Filing Date: 14/Dec/1982

Abstract:

Blood platelet concentrate in a plasma-free medium. Method for storage of blood platelets in a plasma-free medium which comprises centrifuging plasma to obtain a platelet pellet, removing the supernatant plasma, and resuspending the platelet pellet in a balanced salt medium. The balanced salt medium is an isotonic solution and may be selected from well known physiologically tolerable salt mediums. Additives to enhance platelet storage can be added to the salt medium.

Priority: CA19820414583 Applic. Date: 1982-11-01

Inventor: ROCK GAIL A [CA]; ADAMS GEORGE A [CA]


Patent No.: US4448195A  Issued: 15/May/1984

Title: Reinforced balloon catheter

Applicant/Assignee:

Application No.: 261810   Filing Date: 08/May/1981

Abstract:

A balloon catheter is formed by blow molding an elongated polyurethane tube so that one section of the tube has a thinned cross sectional balloon area between the distal end of tube which is sealed and its open proximal end. The balloon portion which is positioned adjacent the distal end has a thinner cross sectional area which allows a balloon to be formed if a fluid is introduced into the catheter by a syringe apparatus which is adapted to be attached to the lumen by a connection adaptor. A wire guide member is adapted to be inserted through the lumen for stretching the catheter when it is inserted into a blood vessel to stiffen the catheter and position it in a proper position. The wire guide member may also be mitred at predetermined intervals to determine the position of the catheter within the blood vessel.

Priority:

Inventor: LEVEEN HARRY H [US]; LEVEEN ERIC G [US]; LEVEEN ROBERT F [US]


Patent No.: US4451454A  Issued: 29/May/1984

Title: Prophylaxis and treatment of thromboembolic disorders in man and in warm-blooded animals with bicarbonate salts of alkali metals

Applicant/Assignee:

Application No.: 274386   Filing Date: 16/Jun/1981

Abstract:

Sodium bicarbonate and potassium bicarbonate are systemic anticoagulants that when administered internally inhibit blood coagulation in man and in warm-blooded animals. As such, they are useful and effective in the treatment and/or prevention of thromboembolic diseases, myocardial infarction or other conditions associated with high risk of thromboembolism. Sodium bicarbonate is especially useful for preventing clotting of ptient's blood during kidney dialysis and for preserving citrated human or animal whole blood and plasma indefinitely under proper storage conditions.

Priority:

Inventor: WONG DENNIS W [US]


Patent No.: US4464167A  Issued: 07/Aug/1984

Title: Pheresis apparatus

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 518956   Filing Date: 01/Aug/1983

Abstract:

This invention relates to an improvement in two-port centrifuge bowls in which component yield is enhanced by utilizing the centrifuge bowl for eluttriation, as well as centrifugation. In a particular embodiment, platelet yield is improved by terminating flow of anticoagulated whole blood from the donor to the bowl and pumping low density fluid, preferably plasma, back into the bowl at a relatively high rate to elutriate centrifugally separated cells in the bowl.

Priority: US1981-299194 Applic. Date: 1981-09-03

Inventor: SCHOENDORFER DONALD W [US]; HANSEN LEE E [US]


Patent No.: US4468378A  Issued: 28/Aug/1984

Title: Oxysulfonic derivative of copolymer of acrolein and acrylic acid and direct action anticoagulant on its basis

Applicant/Assignee:

Application No.: 268202   Filing Date: 29/May/1981

Abstract:

According to the invention, the oxysulfonic derivative of the copolymer of acrolein and acrylic acid is of the following formula: where n=190 to 600, m=190 to 500, and p=830 to 850. This biologically active compound can be used as a direct and prolonged action blood antiacoagulant to be administered in the form of 1- or 2-percent solutions. The preparation according to the invention features a long shelf and has a longer action than the well-known heparin.

Priority: US1980-169242 Applic. Date: 1980-07-16

Inventor: VORONKOV MIKHAIL G [SU]; PLATONOVA ADA T [SU]; ANNENKOVA VLADISLAVA Z [SU]; ANNENKOVA VALENTINA M [SU]; KAZIMIROVSKAYA VALENTINA B [SU]; UGRJUMOVA GALINA S [SU]


Patent No.: US4473552A  Issued: 25/Sep/1984

Title: Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells

Applicant/Assignee:

Application No.: 403939   Filing Date: 02/Aug/1982

Abstract:

An anaerobic method for preserving mammalian blood, mammalian tissue or living-cell containing components of either in a state of suspended animation, and the products of that method, are described. The method involves adding the substance to be preserved to a receptacle containing anticoagulant and low molecular weight hydroxyethyl starch, hydroxypropyl starch or polystarch containing from about 450 to about 1000 glucose units per molecule, mixing well, while maintaining the temperature in the range of from about 35 DEG to about 40 DEG F., and storing the resulting mixture at the same temperature. In a preferred embodiment which preserves blood, tissue or a component indefinitely, the structure is lightly crosslinked (i.e., about 1 cross-link per 50 g glucose units) with the aid of a water-soluble cross-linking agent of the acrylamide type, to form a gel structure. When it is desired to use the preserved material, the swelled starch derivative may be liquefied, or the gel may be broken, by an isotonic wash or by microwaving. The bulk of the starch derivative and any acrylamide type crosslinker present are removed by filtration, whereupon the preserved material may be used in the same way as a freshly collected substance containing living cellular material might be used.

Priority: US1981-244137 Applic. Date: 1981-03-16

Inventor: JOST LEONORA I [US]


Patent No.: US4474568A  Issued: 02/Oct/1984

Title: Multipurpose component container and anticoagulant bag

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 341508   Filing Date: 21/Jan/1982

Abstract:

A multipurpose blood processing bag is described for a system in which anticoagulant and whole blood are mixed outside of the prior art anticoagulated whole blood bag in order to minimize collection lesion. In this system, whole blood and anticoagulant from a multipurpose container are mixed at the phlebotomy needle and the anticoagulated whole blood passed to the anticoagulated whole blood bag. The anticoagulated whole blood may then be separated in a pheresis procedure into components such as plasma or platelets and the separated components stored in the (now empty) multipurpose container.

Priority:

Inventor: SCHOENDORFER DONALD W [US]; KINGSLEY GORDON F [US]


Patent No.: US4478825A  Issued: 23/Oct/1984

Title: Warm ethanol method for preparation of low fibrinogen antihemophilic factor

Applicant/Assignee: ARMOUR PHARMACEUTICAL COMPANY

Application No.: 542243   Filing Date: 14/Oct/1983

Abstract:

Antihemophilic factor (AHF), a blood protein component necessary for clotting of normal whole blood, is extracted and concentrated from a cryoprecipitate suspension containing AHF and fibrinogen as its principal components by: selectively precipitating fibrinogen from a water-ethanol solution and removing the ethanol therefrom.

Priority:

Inventor: BLOOM JAMES W [US]


Patent No.: US4500309A  Issued: 19/Feb/1985

Title: Method for regional anticoagulation during extracorporeal dialysis

Applicant/Assignee: THE KANSAS UNIVERSITY ENDOWMENT ASSOCIATION

Application No.: 375890   Filing Date: 07/May/1982

Abstract:

An improved hemodialysis method (which may optionally include a hemoperfusion step) including regional extracorporeal citrate anticoagulation is disclosed which permits complete elimination of conventional heparin treatment and possible consequent medical complications from heparin use. The method preferably comprises removing blood from a patient at a level of at least about 80 milliliters per minute, infusing citrate anticoagulant into the blood at a level of up to about 10 millimoles of citrate anion per liter of blood, treating the blood (e.g., by dialysis and hemoperfusion if desired), thereafter infusing a calcium compound into the blood to restore proper calcium ion level and coagulative properties, and returning the blood to the patient. A calcium-free acetate or bicarbonate dialysate is advantageously employed. A charcoal perfusion filter can optionally be used in conjunction with the dialyzer apparatus.

Priority:

Inventor: DIEDERICH DENNIS A [US]; WIEGMANN THOMAS B [US]; PINNICK ROBERT V [US]


Patent No.: US4501731A  Issued: 26/Feb/1985

Title: Treatment of disparate bleeding disorders with factor X zymogen

Applicant/Assignee:

Application No.: 508167   Filing Date: 27/Jun/1983

Abstract:

The invention provides a method for the treatment of disparate bleeding disorders comprising the administration of factor X zymogen in amounts sufficient to control pathological bleeding, and a therapeutic product based on the coagulant activity of a factor X zymogen-phospholipid-factor Va clotting system. The product is generally substantially free of activators for the factor X zymogen.

Priority:

Inventor: TISHKOFF GARSON H [US]; ESTRY DOUGLAS W [US]


Patent No.: US4501816A  Issued: 26/Feb/1985

Title: Method of determining immunoglobulin levels in mammals

Applicant/Assignee:

Application No.: 429044   Filing Date: 30/Sep/1982

Abstract:

A method of determining the presence of abnormal immunoglobulin levels in animal body fluids involves (a) forming a reaction mixture of a body fluid and an effective amount of an appropriate aldehyde

(b) timing the rate of reaction of the aldehyde to gel formation

and (c) comparing the rate of reaction of the reaction mixture to a known rate of reaction of a known mixture of the same aldehyde and body fluid containing a known quantity of an immunoglobulin.

Priority:

Inventor: MOLLA ABERRA [US]


Patent No.: US4508821A  Issued: 02/Apr/1985

Title: Detection of white cell associated bacteria with a fluorescent dye

Applicant/Assignee: BECTON DICKINSON AND COMPANY

Application No.: 510537   Filing Date: 05/Jul/1983

Abstract:

A method for detection of intracellular bacteria in a blood sample by staining with ethidium bromide and observing microscopically using fluorescence is provided. The bacteria stain rapidly and selectively and are detectable in complex mixtures. The bacteria may be in whole blood or may optionally be partially isolated or purified before staining.

Priority:

Inventor: MANSOUR JAMES D [US]; SCHULTE THOMAS [US]


Patent No.: US4510135A  Issued: 09/Apr/1985

Title: Orally administered heparin

Applicant/Assignee: RESEARCH CORPORATION

Application No.: 370155   Filing Date: 21/Apr/1982

Abstract:

An orally administrable heparin comprising: a complex of heparin with (1) a protonated tertiary organic ammonium ion having the formula: wherein R1, R2 and R3 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R1 and R3 together with the N atom can form a pyrrolidine, imidazole or morpholine ring

or (2) an ester-containing quaternary ammonium ion having the formula: wherein R4, R5 and R6 each independently represent a branched or unbranched alkyl group of 1 to 12 carbon atoms, which may be unsubstituted or substituted with hydroxy or alkoxy groups, or R4 and R6 together with the N atom can form a pyrrolidine, imidazole or morpholine ring

R7 represents an alkyl group of 4 to 16 carbon atoms

and R8 represents a hydrogen atom or a methyl group.

Priority:

Inventor: TENG LIN-NAR L [US]


Patent No.: US4512348A  Issued: 23/Apr/1985

Title: Device for automatically and continuously measuring the constituent parts of blood

Applicant/Assignee: KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU

Application No.: 371482   Filing Date: 23/Apr/1982

Abstract:

At the time of drawing the blood continuously from the vein of the patient by means of a catheter and measuring the concentration of a specified constituent part contained in the blood automatically and continuously for long hours, the sample liquid and two sorts of correcting liquids (standard liquid I and base liquid) are sucked by a single sampling nozzle in prescribed order and are supplied to the measuring section through a common channel. Each of the liquids are diluted with a buffer solution at the identical rate with the manifold in the measuring section, are separated from one another through the interposition of air layers among them, and supplied to a sensor. The outputs of the measured sample liquid from the sensor are corrected by the outputs of each of the neighboring measured correcting liquids in succession and are displayed as measured values. In the blood-drawing section, there is used a double-current catheter having the first and second catheter arrangements which are constructed so as to be incorporated directly into the tube pump.

Priority: JP19810063160 Applic. Date: 1981-04-24; JP19810150924U Applic. Date: 1981-10-09

Inventor: UCHIGAKI TAKATOSHI [JP]; SAITO AKIO [JP]; YAMADA NAOKI [JP]


Patent No.: US4515890A  Issued: 07/May/1985

Title: Immunoassay of terminal deoxynucleotidyl transferase

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 440129   Filing Date: 08/Nov/1982

Abstract:

This disclosure relates to a method for the quantitative in vitro determination of terminal deoxynucleotidyl transferase in human blood extracts, bone marrow extracts and lymphocyte extracts and wherein the terminal deoxynucleotidyl transferase is extracted with an extractant containing a nonionic surfactant, an anticoagulant and a reducing agent.

Priority:

Inventor: MANDERINO GEORGE L [US]; SUAREZ ADORACION F [US]


Patent No.: US4516398A  Issued: 14/May/1985

Title: Method of use of an ultrasonic surgical pre-aspirator having a orifice by-pass

Applicant/Assignee: COOPER LASERSONICS, INC

Application No.: 617146   Filing Date: 05/Jun/1984

Abstract:

The method of aspirating body tissue and blood from a surgical site along a suction passage having a suction port at an ultrasonically vibrated end of a tool for fragmenting the tissue at the surgical site is improved by introducing an anti-coagulant fluid into the suction passage independently of the suction port.

Priority: US1980-195205 Applic. Date: 1980-10-08

Inventor: WUCHINICH DAVID G [US]


Patent No.: US4526714A  Issued: 02/Jul/1985

Title: Conjugates of anticoagulant and protein

Applicant/Assignee: CORDIS EUROPA N.V

Application No.: 449248   Filing Date: 13/Dec/1982

Abstract:

Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

Priority:

Inventor: FEIJEN JAN [NL]; HENNINK WILHELMUS E [NL]


Patent No.: US4529614A  Issued: 16/Jul/1985

Title: One step anticoagulant coating

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 326712   Filing Date: 02/Dec/1981

Abstract:

This invention relates to single-step coating methods for coating substrates such as plastics or glass to impart properties to the substrate which are anticoagulant and hydrophobic, and to substrates so coated. The method is particularly useful in coating the internal surfaces of blood test vessels, such as microcontainers or VACUTAINERS TM for receiving blood samples for subsequent testing. The method herein imparts the desired properties to the vessel in a single step by combining silicone containing material in a water vehicle to which has been added a quantity of an anticoagulant, such as heparin or ethylene diamine tetraacetic acid (EDTA), followed by air drying.

Priority:

Inventor: BURNS JAMES A [US]


Patent No.: US4540406A  Issued: 10/Sep/1985

Title: Anticoagulant delivery system for use with an auto-transfusion system

Applicant/Assignee: THORATEC LABORATORIES CORPORATION

Application No.: 490675   Filing Date: 02/May/1983

Abstract:

Anticoagulant is added to blood being aspirated through a hand-held wand having a venturi throat. The anticoagulant flows into the wand from a generally closed anticoagulant reservoir higher than the wand as replacement air flows into the anticoagulant air reservoir. This air inflow is controlled by a regulator fixed on the wand and in accordance with the amount of aspirated blood flowing in through the venturi throat.

Priority:

Inventor: MILES CLIVE [US]


Patent No.: US4543328A  Issued: 24/Sep/1985

Title: Process for detecting pathogens

Applicant/Assignee: BOEHRINGER MANNHEIM GMBH

Application No.: 190540   Filing Date: 24/Sep/1980

Abstract:

Process and device for the detection of pathogens, such as bacteria, fungi and viruses, in blood in the presence of an anticoagulant agent. The pathogen is separated in an extracorporeal circulation of the blood with a biocompatible adsorbent which selectively binds the pathogen and thereafter detects by bacteriological, mycological, virological or electron microscopic methods.

Priority: DE19782826416 Applic. Date: 1978-06-16

Inventor: KELLER FRANZ [DE]; HENNEMANN HANS [DE]


Patent No.: US4543339A  Issued: 24/Sep/1985

Title: Early pregnancy detection by detecting enhanced blood platelet activation

Applicant/Assignee:

Application No.: 475546   Filing Date: 15/Mar/1983

Abstract:

A method and reagent system for detecting pregnancy in a mammal at an early stage by detecting enhanced activation of blood platelets.

Priority: AU1982PF03148 Applic. Date: 1982-03-16

Inventor: O'NEILL CHRISTOPHER [AU]


Patent No.: US4547186A  Issued: 15/Oct/1985

Title: Autotransfusion system

Applicant/Assignee:

Application No.: 472763   Filing Date: 07/Mar/1983

Abstract:

A system for autotransfusion has an aspirating wand or tube coupled to a vacuum source through a reservoir for receiving aspirated blood. From that reservoir blood flows to a receiving bag in a relatively low position below the elevation of the patient. When there is sufficient blood supply in the bag, the bag is elevated from its lower position to a point higher than the patient. Blood then flows from the elevated bag by gravity through a conducting tube and a needle into the patient. When the bag is then substantially empty, it is again lowered to an elevation lower than the patient for repetition of the operation. If desired, an anticoagulant can be introduced into the aspirated blood.

Priority:

Inventor: BARTLETT ROBERT H [US]


Patent No.: US4547190A  Issued: 15/Oct/1985

Title: Inlet blood filter assembly

Applicant/Assignee: FILTERTEK, INC

Application No.: 444840   Filing Date: 26/Nov/1982

Abstract:

The present invention relates to an inlet blood filter assembly. The inlet blood filter assembly includes a drip chamber, filter chamber and pump chamber. The assembly is constructed so that blood flows through the drip chamber, into the filter chamber and into the pump chamber. The inlet blood filter assembly is blow molded so that the thickness of the walls of the chambers may be varied.

Priority:

Inventor: LEASON HAYDEN L [US]


Patent No.: US4551131A  Issued: 05/Nov/1985

Title: Autotransfusion system with anticoagulant delivery system

Applicant/Assignee: THORATEC LABORATORIES CORPORATION

Application No.: 490673   Filing Date: 02/May/1983

Abstract:

A movable blood aspiration wand, especially for use in autotransfusion, carries with it a tank for anticoagulant replenished from an anticoagulant source fixed at a high source and is connected to a blood reservoir at a low elevation. Differences in wand height relative to the source and to the blood reservoir are compensated for, so that differences in wand height and corresponding blood and anticoagulant head do not substantially vary the anticoagulant proportion added to the aspirated blood.

Priority:

Inventor: MILES CLIVE [US]; SCHNEIDERMAN GARY [US]


Patent No.: US4551138A  Issued: 05/Nov/1985

Title: Cannula device and medical bag having the same

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 714342   Filing Date: 20/Mar/1985

Abstract:

A cannula device has a hollow needle, and a hub which supports the hollow needle at the proximal end portion thereof and which is made of a hard plastic. A protector comprises a hollow body whose distal end is closed and whose proximal end is open and which is made of a hard plastic. The protector is detachably mounted on the hub such that the hollow body houses the hollow needle therein and the proximal end of the hollow body covers the distal end portion of the hub. A resilient layer is formed between the inner circumferential surface of the proximal end portion of the hollow body and the outer circumferential surface of the distal end portion of the hub.

Priority: JP19820039244 Applic. Date: 1982-03-12

Inventor: SHINOHARA SHUICHI [JP]


Patent No.: US4552552A  Issued: 12/Nov/1985

Title: Pump system for use with dialysis and like apparatus

Applicant/Assignee: FRESENIUS AG

Application No.: 466645   Filing Date: 15/Feb/1983

Abstract:

The present invention is with respect to a dialysis pumping system, and more specially to a single needle dialysis apparatus with a dialyser having blood and dialysate circuits and which has blood inlets and outlets that are joined by intake and outlet lines with at least one blood connection. The intake line has a driving pump and a blood pump powered by driving fluid from said driving pump and pump valves placed upstream and downstream from the said blood pump. Furthermore the outlet line has a further shut off valve. The blood pump unit has a generally stiff housing with a pipe-like liner in it walling off the space in the housing into a first chamber for blood and a second driving fluid chamber that is joined up with the driving pump, that may be a bellows pump and is joined up with the housing by an air circuit with sensors or valve driving parts for controlling motion of air into and out of the housing.

Priority: DE19823205449 Applic. Date: 1982-02-16

Inventor: POLASCHEGG HANS-DIETRICH [DE]; MATHIEU BERND [DE]


Patent No.: US4559034A  Issued: 17/Dec/1985

Title: Line for use in body fluid treatment

Applicant/Assignee: KAWASUMI LABORATORIES, INC KURARAY CO., LTD

Application No.: 559855   Filing Date: 12/Dec/1983

Abstract:

A method for treating blood uses a tubular body fluid passageway member at least part of which is made of a flexible material, an outer tubular member which is made of a nonflexible material and contains said tubular body fluid passageway member hermetically enclosed therein, a pressure detecting member for monitoring the pressure of the flowing body fluid by means of a fluid filled in the hermetically closed space between the outside surface of said tubular body fluid passageway member and said outer tubular member without substantial contact of the body fluid with air, and a body fluid filtering member comprising a filter. The method is especially useful for non-anticoagulant hemodialysis.

Priority: JP19810055667U Applic. Date: 1981-04-16; JP19810099643U Applic. Date: 1981-07-03

Inventor: KIRITA YASUZO [JP]; KAWAHASHI MASARU [JP]; KARIU KEIKI [JP]; SUNAHARA KIMIHISA [JP]; NAITO HIDEMUNE [JP]


Patent No.: US4569332A  Issued: 11/Feb/1986

Title: Method and apparatus for treating a heart patient through the coordinating efforts of balloon pumping and dispensing catheters

Applicant/Assignee:

Application No.: 484432   Filing Date: 13/Apr/1983

Abstract:

Method and apparatus for treating heart patients employing the coordinated efforts of dispensing and balloon pumping catheters. A balloon pumping catheter is inserted and properly positioned within the aortic arch. The balloon catheter has a lumen through which a dispensing catheter extends. The distal end of the dispensing catheter is guided to the operative position, preferably by means of a guide wire extending through the dispensing catheter. The guide wire is removed prior to a dispensing operation. Measured doses of a medicinal solution, such as, for example, a blood thinner, are periodically dispensed through the dispensing catheter and in coordination with the pumping operation. A single pumping source may be utilized for powering the balloon pumping and dispensing operations. An adjustable delay provided between the source and one of the catheter assemblies provides the proper coordination between the balloon pumping and dispensing operations. The dispensing catheter may include a small dilatation balloon having a first lumen for dispensing a medicinal solution and a second lumen for inflating the dilatation balloon.

Priority:

Inventor: SCHIFF PETER [US]; LAMBERT CARY L [US]


Patent No.: US4573961A  Issued: 04/Mar/1986

Title: Electronic control methods for puvapheresis apparatus

Applicant/Assignee: EXTRACORPOREAL MEDICAL SPECIALTIES, INC

Application No.: 665831   Filing Date: 29/Oct/1984

Abstract:

Methods are provided for ensuring the safety of a patient undergoing extracorporeal treatment by irradiation of a photoactivatable reagent in contact with the patient's blood including simultaneous digital and analog monitoring of temperature, voltage and current sensor signals. Also provided is a control system for controlling and regulating the various components of the photophoresis patient treatment system.

Priority:

Inventor: KING MARTIN J [US]


Patent No.: US4578056A  Issued: 25/Mar/1986

Title: Patient photopheresis treatment apparatus and method

Applicant/Assignee: EXTRACORPOREAL MEDICAL SPECIALTIES, INC

Application No.: 665833   Filing Date: 29/Oct/1984

Abstract:

Provided are apparatus and methods of use for extracorporeally treating a patient whereby blood is withdrawn from the patient, separated into a leukocyte enriched portion which, in contact with a photoactivatable reagent, is irradiated and all blood portions being returned to the patient. The preferred apparatus is suitably modified with appropriate tubing sets, valves, pumps, centrifuge and controlling means to perform the patient treatment in three operational phases.

Priority:

Inventor: KING MARTIN J [US]; TROUTNER VERNON H [US]


Patent No.: US4578077A  Issued: 25/Mar/1986

Title: Blood pump applicable to an artifical heart

Applicant/Assignee: NIPPON ZEON CO., LTD

Application No.: 319718   Filing Date: 09/Nov/1981

Abstract:

A blood pump to be utilized as an artificial heart, comprises a housing provided with a port for introducing and discharging fluid, a cover portion for closing the housing tightly, a sac portion defining a blood chamber with the relatively flat or oval shape arranged in the housing, an inlet and outlet conduit portions for the blood provided with a check valve respectively and integrally formed on the cover so as to communicate with the blood chamber, characterized in that, when the blood chamber is compressed, the initial contact point from the opposite inner surfaces of the sac is regulated to locate in the area defined by a circle, the center of which is on the central axis of the wider side of the sac and in the height range between 0.2L and 0.45L from the bottom of the sac and the radius of which is 0.15D, where L is the whole height of the sac, D is the maximum width of the sac and the wider side is defined by the side projected to the vertical plane including the maximum width D of the sac.

Priority: FR19820007439 Applic. Date: 1982-04-29; JP19800157942 Applic. Date: 1980-11-10

Inventor: JOH YASUSHI [JP]


Patent No.: US4585007A  Issued: 29/Apr/1986

Title: Method for continuously measuring a specified ingredient in a diluted liquid

Applicant/Assignee: KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU

Application No.: 493415   Filing Date: 10/May/1983

Abstract:

A method for accurately performing concentration measurements while compensating the dilution ratio as needed during continuous measurement of specified ingredient in the liquid to be tested. The liquid to be tested is diluted by a diluent, wherein the liquid to be tested and the diluent or the mixture of the two and the diluent is transferred by means of the respective tube pumps to a measuring section. Either or both of the quantities of liquid-feeding of those two liquids are changed at the beginning of measuring or in an optional stage during the time of the measurement, diluted and mixed at two or more dilution ratios. Then the real dilution ratio at the time of changing the quantities of the said liquids is found on the basis of the measured value of the substance to be measured at the respective dilution ratios, and the concentration of the substance contained in the liquid to be tested is determined by using the real dilution ratio.

Priority: JP19820082009 Applic. Date: 1982-05-15

Inventor: UCHIGAKI TAKATOSHI [JP]; HYODO HIROSHI [JP]; IWASE TEIJIRO [JP]


Patent No.: US4588587A  Issued: 13/May/1986

Title: Method of treatment to inhibit metastasis

Applicant/Assignee: PENNSYLVANIA HOSPITAL

Application No.: 471197   Filing Date: 01/Mar/1983

Abstract:

Method for treating a patient to inhibit metastasis of malignant cells by administering to the patient a therapeutically effective amount of a composition including a blood anticoagulant and a protease inhibitor. A composition apparently unique for this purpose is a leech salivary gland extract, the anticoagulant effect and protease inhibitory effect of which are believed to be significant. Other significant components may also be present in the leech salivary gland extract and these components may act synergistically in producing the observed antimetastatic effect.

Priority:

Inventor: GASIC GABRIEL J [US]


Patent No.: US4595021A  Issued: 17/Jun/1986

Title: Blood collector

Applicant/Assignee: TERUMO CORPORATION

Application No.: 741036   Filing Date: 04/Jun/1985

Abstract:

A blood collector includes a cylindrical body having a closed end and an open end, and a hollow body is arranged coaxially at the closed end of the cylindrical body and has a hole communicating with the interior of the cylindrical body. A columnar body is arranged within the cylindrical body to be in tight contact with an inner wall thereof, with a distal end defining a blood collection space with the closed end of the cylindrical body. Further, the columnar body has a hole which allows the blood collection space to communicate with the outside. A freeze-dried blood anticoagulant mass is placed inside the blood collection space to cover an inner surface of the closed end of the cylindrical body and to block the hole of the hollow body. A filter is arranged across the hole of the columnar body. The filter is permeable to gases and impermeable to blood at least before being brought into contact with blood in the collection space.

Priority: JP19820022431 Applic. Date: 1982-02-15

Inventor: SHIMIZU ATSUSHI [JP]; ICHIKAWA TOSHIJI [JP]


Patent No.: US4599081A  Issued: 08/Jul/1986

Title: Artificial heart valve

Applicant/Assignee:

Application No.: 430403   Filing Date: 30/Sep/1982

Abstract:

An artificial heart valve of turbine-like construction includes a rotor that translates and rotates to cause a plurality of rotor blades to either occlude or unocclude spaces between adjacent ones of a plurality of stator blades.

Priority:

Inventor: COHEN FRED M [US]


Patent No.: US4604350A  Issued: 05/Aug/1986

Title: Screening test for beta-thalassemia trait and a diagnostic kit for its individualization

Applicant/Assignee:

Application No.: 485327   Filing Date: 15/Apr/1983

Abstract:

A screening test for beta-thalassemia trait carriers is carried out by mixing 10 mu l of blood of the patient with 2 ml of an aqueous solution prepared from glycerol, sodium chloride, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium azide, Acid Green 5 to obtain a suspension. A well cluster, having several wells is used. The suspension is formed in one well and the turbidity is determined by placing a reading scale under the cluster.

Priority: IT19820041564 Applic. Date: 1982-04-29

Inventor: DE MATTEIS MARIA C [IT]


Patent No.: US4609372A  Issued: 02/Sep/1986

Title: Heat sterilizable storage solution for red blood cells

Applicant/Assignee: MILES LABORATORIES, INC

Application No.: 541813   Filing Date: 13/Oct/1983

Abstract:

Aqueous storage solution for red blood cells comprising a stabilized ascorbate derivative and having a pH sufficient to maintain substantially all of the initial concentration of ascorbate derivative and avoid formation of ascorbate degradation products during heat sterilization. A preferred solution includes at least about 90% of the pre-sterilization ascorbate and adenine but is free of dextrose.

Priority:

Inventor: CARMEN RALEIGH A [US]; CHONG CHIYONG [US]; LENG BARRY [US]


Patent No.: US4617700A  Issued: 21/Oct/1986

Title: Process and apparatus for the hygienic extraction and collection of animal blood fit and unfit for human consumption

Applicant/Assignee: ORSZAGOS HUSIPARI KUTATOINTEZET BACSKAI HUSIPARI KOEZOES VALLALAT

Application No.: 583506   Filing Date: 24/Feb/1984

Abstract:

A process for the hygienic extraction and separate collection of animal blood fit and unfit for consumption, comprises stunning the animals prior to stabbing and providing the animals with serial numbers suitable for identification of the carcass and the blood to be extracted. The spot of stabbing on the throat of the animals is disinfected and the animals are cyclically stepped into a stabbing position. The animal is stabbed in the stabbing position with a disinfected stabbing tool which is exchanged for each animal and is provided with a closed outlet a hose-fitted hollow knife. The hygenic blood is extracted through the stabbing tool into one of a plurality of rotating blood collecting tanks arranged on a turntable and moved into an extracting position. An anticoagulant is added to the blood by gravity feed and after filling, the tanks are advanced toward into a first draining position for blood fit for consumption. If all the numbered carcasses pertinent to the blood in the tank in the first drawing position are held impeccable from the point of view of animal healthy examination, a control body effects the draining the blood from the collecting tank into a system for blood fit for consumption. If not impeccable, the tank is advanced with the blood in it forward to a second draining position and drained into a system for blood unfit for consumption. The drained tanks are washed and disinfected and advanced into the extracting position.

Priority: HU19830000853 Applic. Date: 1983-03-14

Inventor: BATORFALVI GEZA [HU]; LENDVAI TIBOR [HU]; RADAI ANTAL [HU]; PONGRAC GABORNE [HU]; SZABO MIKLOS [HU]; SZILARDI JENOE [HU]


Patent No.: US4626431A  Issued: 02/Dec/1986

Title: Storage of red blood cells

Applicant/Assignee: BURROUGHS WELLCOME CO

Application No.: 662709   Filing Date: 19/Oct/1984

Abstract:

Use of compounds of formula (I) (I) to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient. In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia

in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life. Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.

Priority: GB19830028495 Applic. Date: 1983-10-25

Inventor: BATCHELOR JOHN F [GB]; HYDE RICHARD M [GB]; LIVINGSTONE DAVID J [GB]


Patent No.: US4626432A  Issued: 02/Dec/1986

Title: Storage of red blood cells

Applicant/Assignee: BURROUGHS WELLCOME CO

Application No.: 662784   Filing Date: 19/Oct/1984

Abstract:exchange-document system="ops.epo.org" family-id="10550706" country="US" doc-number="4626432" kind="A"> US 4626432 A 19861202 US4626432 19861202 US19840662784 19841019 662784 GB19830028495 19831025 8328495 BURROUGHS WELLCOME CO [US] BURROUGHS WELLCOME CO HYDE RICHARD M [GB] LIVINGSTONE DAVID J [GB] HYDE, RICHARD M, LIVINGSTONE, DAVID J Storage of red blood cells

Priority: GB19830028495 Applic. Date: 1983-10-25

Inventor: HYDE RICHARD M [GB]; LIVINGSTONE DAVID J [GB]


Patent No.: US4634762A  Issued: 06/Jan/1987

Title: Conjugates of anticoagulant and protein

Applicant/Assignee: SENTRON V.O.F

Application No.: 716197   Filing Date: 26/Mar/1985

Abstract:

Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

Priority: NL19810005656 Applic. Date: 1981-12-15

Inventor: FEIJEN JAN [NL]; HENNINK WILHELMUS E [NL]


Patent No.: US4637813A  Issued: 20/Jan/1987

Title: Blood processing assembly including a prepackaged fluid circuit module

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 424823   Filing Date: 27/Sep/1982

Abstract:

The monitor and fluid circuit assembly is used with a blood processing apparatus which is adapted for separating platelets from whole blood. The assembly is easily and simply attached to the apparatus and includes a holder, a plurality of flexible tubings held in and extending through the holder, monitor devices fixed within the holder and series coupled to various ones of the tubings and at least one tubing having a transparent wall section which is positioned adjacent an optical sensor of the apparatus. Several tubings extend in loops from the holder and are adapted for being received over and forming part of peristaltic pumps of the apparatus so that fluid can be pumped through the tubings. Other portions of some of the tubings extending from the holder are held in an umbilicus which is received through a rotatable holder in a centrifuge device of the apparatus. The plastic bag/receptacles are connected to the ends of these tubings and are adapted to be received in the centrifuge device for the centrifuging of fluids therein. Two tubings are adapted to be connected to hypodermic needles which are inserted in the arms of a donor of whole blood to be processed. The assembly of tubings and pressure monitors are made of inexpensive plastic so that the assembly can be discarded after it is used and a platelet separation bag has been detached from the assembly.

Priority: US1979-100975 Applic. Date: 1979-12-06

Inventor: DEVRIES JAMES H [US]


Patent No.: US4639243A  Issued: 27/Jan/1987

Title: Process and apparatus for obtaining blood plasma

Applicant/Assignee:

Application No.: 571399   Filing Date: 17/Jan/1984

Abstract:

A straight-forward, simplified process and apparatus for obtaining blood plasma are provided which employ no pumps or other external flow monitoring devices. Instead, a plasma filtering assembly is suspended a predetermined distance below the injection site to employ the forces of gravity to separate plasma from the other components of whole blood.

Priority: DE19833302383 Applic. Date: 1983-01-25

Inventor: SCHMIDT BAERBEL [DE]; SAMTLEBEN WALTER [DE]; LYSAGHT MICHAEL J [US]


Patent No.: US4648866A  Issued: 10/Mar/1987

Title: Process/apparatus for the withdrawal/return of body fluids

Applicant/Assignee: RHONE-POULENC S.A

Application No.: 628845   Filing Date: 09/Jul/1984

Abstract:

Process/apparatus for the processing of body fluids, advantageously comprising plasmapheresis technique for the fractionation of whole blood, features (i) means, e.g., a common blood transfusion needle, for withdrawing and returning body fluid from and to a living patient

(ii) a body fluid separating module which comprises an upstream first compartment and a downstram second compartment, and having a semi-permeable membrane body fluid separator disposed therebetween

(iii) first conduit means communicating said withdrawal and return means (i) with the upstream first compartment of said separating module (ii)

(iv) means provided along said first conduit (iii) for conveying body fluid in either direction therein

(v) means responsive to said conveying means (iv), adapted to monitor the pressure of body fluid circulating in said first conduit (iii), and provided between said withdrawal and return means (i) and said conveying means (iv)

(vi) means for collecting body fluid transported across said semi-permeable membrane and communicating with the downstream second compartment of said separating module (ii)

(vii) second conduit means communicating the upstream first compartment of said module (ii) to (viii) means for containing body fluid which has not been transported across said semi-permeable membrane thereof, (ix) third conduit means communicating said container means (viii) to said first conduit means (iii) at a point intermediate said conveying means (iv) and the upstream first compartment of said separating module (ii)

(x) means provided along said first conduit (iii) at a point intermediate the upstream first compartment of said separating module (ii) and the juncture of communication between said container means (viii) and the said first conduit means (iii), for conveying body fluid therein in the direction of the said upstream first compartment

and (xi) means for ensuring that the pressure across the said semi-permeable membrane of any body fluid in contact therewith does not exceed predetermined value.

Priority: FR19830011572 Applic. Date: 1983-07-07

Inventor: MALBRANCQ JEAN-MICHEL [FR]; VANTARD GEORGES [FR]


Patent No.: US4653511A  Issued: 31/Mar/1987

Title: Microsample blood collecting device

Applicant/Assignee:

Application No.: 658405   Filing Date: 05/Oct/1984

Abstract:

A microsample device for blood sample collection comprises a hypodermic needle to which is attached a mixing chamber having an enlarged bore relative to the bore of its inlet and outlet conduits, and a supply of a soluble solid anticoagulant contained within the chamber. The anticoagulant is automatically mixed with the blood sample in the mixing chamber, eliminating the need for mixing balls or other mechanical mixing elements. The exit conduit from the mixing chamber leads to a capillary tube of sufficient length to accommodate a desired blood sample. The free end of the capillary tube is provided with a hydrophobic filter which permits air to escape from the interior of the collecting device as the blood sample enters but which blocks the further flow of blood as soon as the device is filled.

Priority:

Inventor: GOCH THOMAS A [US]; MEEK JOHN R [US]


Patent No.: US4654327A  Issued: 31/Mar/1987

Title: Quaternary ammonium complexes of heparin

Applicant/Assignee: RESEARCH CORP

Application No.: 804214   Filing Date: 03/Dec/1985

Abstract:

A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of where R1 and R2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms

and R, R' and R'' are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, where R1, R2 and R'' are as defined above, where R3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms

and R1, R2, R3 and R and R' have the meanings given above

and where R1, R2 and R3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound. The compound thus formed has a structural formula selected from the group consisting of where R and R' are the same or different and are saturated or unsaturated aliphatic containing at least 10 carbon atoms

and

Priority: US1982-370155 Applic. Date: 1982-04-21; US1982-452493 Applic. Date: 1982-12-23

Inventor: TENG LIN-NAR L [US]


Patent No.: US4655742A  Issued: 07/Apr/1987

Title: Process/apparatus for the withdrawal/return of body fluids

Applicant/Assignee: RHONE-POULENC S.A

Application No.: 631219   Filing Date: 16/Jul/1984

Abstract:

Process/apparatus for the processing of body fluids, advantageously comprising plasmapheresis technique for the fractionation of whole blood, features (i) means, e.g., a common blood transfusion needle, for withdrawing and returning body fluid from and to a living patient, (ii) a body fluid separating module which comprises an upstream first compartment and a downstream second compartment, and having a semipermeable membrane body fluid separator disposed therebetween, (iii) first conduit means communicating said withdrawal and return means (i) with the upstream first compartment of said separating module (ii), (iv) means provided along said first conduit (iii) for conveying body fluid in either direction therein, (v) means adapted to monitor the pressure of body fluid circulating in said first conduit (iii), and provided between said conveying means (iv)

and the inlet end of the upstream first compartment of said separating module (ii), (vi) second conduit means communicating the upstream first compartment of said separating module (ii) to (vii) means for flexibly containing body fluid which has not been transported across the semipermeable membrane thereof, (viii) means for collecting body fluid transported across said semipermeable membrane and communicating with the downstream second compartment of said separating module (ii), (ix) means adapted to monitor the amount of body fluid withdrawn from the patient during any given withdrawal phase, and (x) means adapted to expel body fluid from said container means (vii) and to return same to the patient.

Priority: FR19830011932 Applic. Date: 1983-07-13

Inventor: VANTARD GEORGES [FR]


Patent No.: US4656254A  Issued: 07/Apr/1987

Title: Method of preparing alpha-1-proteinase inhibitor and antithrombin III

Applicant/Assignee: MILES LABORATORIES, INC

Application No.: 803184   Filing Date: 02/Dec/1985

Abstract:

There is disclosed an improved method for separating one of alpha-1-proteinase inhibitor (also known as alpha-1 antitrypsin) and antithrombin-III from an aqueous solution of plasma proteins containing the same, such as from Cohn Fraction IV-1, Cohn Fraction IV, reworks of Cohn Fraction IV and IV-1, Cohn Effluent II & III and Cohn Effluent I. The method includes the steps of first holding an aqueous solution of plasma proteins containing one of alpha-1-proteinase inhibitor and antithrombin-III in a relatively large volume of buffer solution as solvent and at a pH adjusted to be relatively basic when compared to conditions heretofore known, and at a temperature in the range of from 2 DEG -50 DEG C. for a period of about 0.2-24 hours. Following the above treatment, alpha-1-proteinase inhibitor and antithrombin-III are obtained by applying conventional techniques to the resulting solution. Accordingly, the solution is then mixed with a polyalkylene glycol, e.g. polyethylene glycol, in the range of from as low as 8% to as high as 23% (w/v) based on volume of solution to selectively precipitate unwanted proteins. The alpha-1-proteinase inhibitor is then separated from the supernatant solution by adsorption on an anion exchange resin or by precipitation by further addition of a polyalkylene glycol, e.g. polyethylene glycol. The method of the invention provides an improvement in the yield of alpha-1-proteinase inhibitor.

Priority:

Inventor: SHEARER MICHAEL A [US]; SASAGAWA PAMELA K [US]; HEIN RONALD H [US]


Patent No.: US4670013A  Issued: 02/Jun/1987

Title: Container for blood and blood components

Applicant/Assignee: MILES LABORATORIES, INC

Application No.: 786455   Filing Date: 11/Oct/1985

Abstract:

A blood container for storage of blood and blood components is disclosed. The invention comprises a blood container and a multiple blood bag system which includes a donor bag and one or more satellite bags connected by flexible tubing. The blood bag is made of polyvinyl chloride (PVC) plasticized with a blend of plasticizers comprising a plasticizer resistant to blood extraction such as a triester of trimellitic acid and a 7-10 carbon alcohol and a blood extractable plasticizer such as a dioctyl phthalate or dioctyl adipate and is suitable for long term storage of whole blood, red cells and platelets. The blood container is made of a thin material which contains a plasticizer composition extractable at much lower levels by blood or plasma than conventional phalate plasticized PVC. Blood and blood components processed or stored in the blood bags will exhibit relatively low levels of contamination by plasticizer.

Priority: US1982-453385 Applic. Date: 1982-12-27

Inventor: BARNES BRUCE E [US]; MAHAL MOHAN S [US]


Patent No.: US4673688A  Issued: 16/Jun/1987

Title: Partial amine salts of EDTA as blood anticoagulant

Applicant/Assignee: MITSUBISHI RAYON CO., LTD

Application No.: 914512   Filing Date: 02/Oct/1986

Abstract:

There is disclosed a blood anticoagulant consisting essentially of a salt formed by reacting ethylenediaminetetraacetic acid with an alkylenediamine having 2 to 8 carbon atoms in a molar ratio of ethylenediaminetetraacetic acid to alkylenediamine ranging from 1:0.5 to 1:2, or with an alkylamine having 1 to 8 carbon atoms in a molar ratio of ethylenediaminetetraacetic acid to alkylamine ranging from 1:1 to 1:3. This blood anticoagulant is suitable for preventing coagulation of blood collected for purpose of hematological examination.

Priority: JP19850064612 Applic. Date: 1985-03-28

Inventor: MURASHIGE YOSHIO [JP]; YANAGASE AKIRA [JP]; KAWACHI YASUNORI [JP]; SOGA JUNKO [JP]


Patent No.: US4675159A  Issued: 23/Jun/1987

Title: Method and device for disinfecting biological fluids and container for same

Applicant/Assignee:

Application No.: 780668   Filing Date: 29/Sep/1985

Abstract:

A technique and receptacle for disinfecting biological fluids such as whole blood is described in which the disinfectant is prepositioned in a receptacle for biological fluids utilized for clinical evaluation in an amount which is sufficient to disinfect the fluid without interfering with subsequent clinical evaluation. The invention is specifically directed to disinfecting viral contaminants in blood by providing a closed container for the blood specimen which contains an amount of an aldehyde based disinfectant such as glutaraldehyde sufficient to destroy without otherwise affecting the integrity of the specimen for future evaluation. The amount of aldehyde based disinfectant positioned in the container is adjusted to provide an ultimate concentration in the blood specimen of aldehyde of about 0.1 to 2.5 weight percent and is buffered to a pH of about 7.2 to 8.5 percent preferably about 7.4. To increase the stability and shelf life of the sample container and disinfectant, activation or buffering to the indicated pH range does not take place until or just prior to introduction of the specimen into the container. In a particularly preferred embodiment of the invention, the closed sample container is evacuated and provided with an elastomeric stopper adapted to receive the hollow needle of a syringe whereby the blood specimen is introduced into the container directly from the donor.

Priority:

Inventor: AL-SIOUFI HABIB [US]


Patent No.: US4678671A  Issued: 07/Jul/1987

Title: Conjugates of anticoagulant and protein

Applicant/Assignee: CORDIS EUROPA N.V

Application No.: 905573   Filing Date: 09/Sep/1986

Abstract:

Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.

Priority: NL19810005656 Applic. Date: 1981-12-15; US1982-449248 Applic. Date: 1982-12-13

Inventor: FEIJEN JAN [NL]; HENNINK WILHELMUS E [NL]


Patent No.: US4680025A  Issued: 14/Jul/1987

Title: Blood component collection systems and methods

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 833530   Filing Date: 27/Nov/1984

Abstract:

A blood component collection system and method each utilizes centrifugation to first separate whole blood into red blood cells and platelet-rich plasma. Noncentrifugal separation is then utilized to further separate the platelet-rich plasma into platelet concentrate and plasma which is virtually free of platelets. The system and method are applicable for use in association with both batch and continuous flow procedures.

Priority: US1982-411058 Applic. Date: 1982-08-24

Inventor: KRUGER ROBERT J [US]; BROWN RICHARD I [US]


Patent No.: US4680177A  Issued: 14/Jul/1987

Title: Processes for the production of blood products

Applicant/Assignee: GARFIELD WESTON TRUST RES HEART CO ROYAL COLLEGE OF SURGEONS BRITISH POSTGRADUATE MED

Application No.: 579905   Filing Date: 28/Dec/1983

Abstract:

PCT No. PCT/GB83/00127 Sec. 371 Date Jan. 3, 1984 Sec. 102(e) Date Jan. 3, 1984 PCT Filed Apr. 28, 1983 PCT Pub. No. WO83/03830 PCT Pub. Date Nov. 10, 1983.Blood products and derivatives, such as procoagulants-e.g. Factor VIII and prothrombin-plasma proteins, immunoglobulin and complement growth factors and various leucocytes, are obtained from shed blood or its tissue precursor, bone marrow, that has been anticoagulated by the use of a neutral salt that does not bind calcium ions. The preferred anticoagulants are salts containing the divalent ions calcium, magnesium, barium or strontium. Salts of calcium and magnesium are especially preferred because of their relatively lower toxicity, the salt of choice being a magnesium salt, for instance magnesium chloride, because magnesium salts exhibit the required anticoagulating action at levels compatible with retention of normal ionic strength and osmolarity. The toxicity of the neutral salt is eliminated by its removal.

Priority: GB19820012306 Applic. Date: 1982-04-28

Inventor: GRAY CHARLES R W [GB]; CRAWFORD NEVILLE [GB]


Patent No.: US4687000A  Issued: 18/Aug/1987

Title: Composition and sampling receptacle method for treating blood with anticoagulant

Applicant/Assignee: RADIOMETER A/S

Application No.: 713911   Filing Date: 15/Mar/1985

Abstract:

PCT No. PCT/DK84/00069 Sec. 371 Date Mar. 15, 1985 Sec. 102(e) Date Mar. 15, 1985 PCT Filed Jul. 13, 1984 PCT Pub. No. WO85/00662 PCT Pub. Date Feb. 14, 1985.In order to counteract coagulation of a blood sample which is collected from an animal or a human body (24) and introduced into a receptacle, such as a syringe chamber (14), an anticoagulant is added to the sample within the receptacle. The anticoagulant may be capable of binding cation species in the blood, which are subsequently to be measured. Such cation species comprise hydrogen ions, ammonium ions, alkaline metal ions such as potassium and sodium ions, and alkaline earth metal ions such as magnesium and calcium ions. In order to compensate for the proportions of selected cation species which are bound by the anticoagulant, an additive containing such cation species is added to the blood sample so as to obtain substantially the same concentration of the selected cation species in an unbound condition in the anticoagulant treated blood sample as in the untreated blood sample. The anticoagulant and the additive are preferably added to the blood sample as a composition which may be deposited on or carried by a carrier body (15) which may be arranged within the receptacle in which the blood sample is introduced. The bulk density of the nonwetted carrier body is preferably smaller than the specific weight of the blood sample so as to avoid trapping of air bubbles within the receptacle. In its wetted condition the bulk density of the carrier body is preferably also different from the specific weight of the blood sample so that the carrier body (15) may be used as an agitating member improving mixing of the anticoagulant composition with the blood sample. The carrier body (15) may, for example, be made of filtering paper.

Priority: DK19840002861 Applic. Date: 1984-06-12; DK19830003261 Applic. Date: 1983-07-15

Inventor: EISENHARDT ANNE R [DK]; HANSEN OLE M [DK]


Patent No.: US4687580A  Issued: 18/Aug/1987

Title: Membrane apparatus/process adapted for plasmapheresis

Applicant/Assignee: RHONE-POULENC S.A

Application No.: 456821   Filing Date: 10/Jan/1983

Abstract:

Apparatus/process for the withdrawal and return of liquid materials from a donor source, comprising means for withdrawing whole blood from a mammalian donor

a membranous blood filtration cell which includes a membrane separator/filter, a compartment downstream therefrom for receiving a blood plasma fraction and a compartment upstream thereof for receiving a blood cellular component fraction

conduit means for communicating the withdrawal means and an inlet end of the upstream compartment

a collection vessel

conduit means for communicating an outlet end of said upstream compartment and said collection vessel

means for determining the volume of liquid material withdrawn from the donor source during a withdrawal stage

means for back-filtering and returning liquid material from said collection vessel to the donor source

a second collection vessel

and conduit means for communicating an outlet end of the downstream compartment and the second collection vessel.

Priority: FR19820000485 Applic. Date: 1982-01-11

Inventor: MALBRANCQ JEAN-MICHEL [FR]; BOUVERET ELISABETH [FR]; ANGLERAUD RENE [FR]


Patent No.: US4693972A  Issued: 15/Sep/1987

Title: Composition and method for rapid detection of microorganisms in clinical samples

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 571001   Filing Date: 16/Jan/1984

Abstract:

A method for rapid detection of microorganisms in a body fluid sample includes detecting the microorganisms after treatment of the sample with a lysing agent in order to dissolve sample components other than microorganisms, and staining with a fluorescent dye. The lysing agent may be part of a composition which includes a culture medium thereby providing simultaneous lysis and growth before staining. Detection is preferably accomplished by reliance on the fluorescence emitted by the dye having been properly excited by light energy. A composition suitable for use in the above-described method includes a growth medium and a lysing agent.

Priority:

Inventor: MANSOUR JAMES D [US]; SCHULTE THOMAS H [US]; NEECE VERNON R [US]


Patent No.: US4703036A  Issued: 27/Oct/1987

Title: Peptide-aldehydes, process for the preparation thereof and pharmaceutical compositions containing the same

Applicant/Assignee: RICHTER GEDEON VEGYESZETI GYAR RT

Application No.: 811937   Filing Date: 20/Dec/1985

Abstract:

The invention relates to new peptide-aldehydes and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. According to a feature of the present invention there are provided new peptide-aldehyde derivatives corresponding to the general formula (I) (I) wherein R1 represents hydrogen or C1-6 alkyl group, R2 stands for C1-6 alkyl group, furthermore R1 and R2 are linked to the amino group of the Xxx alpha-amino acid, Xxx represents a D-phenylalanine residue or a D-alpha-amino acid group having in the side chain a C1-4 alkyl group, Pro stands for L-proline residue, Yyy stands for L-, D- or DL-arginine residue and A represents an acid residue. The new peptide-aldehyde derivatives of the invention possess valuable anticoagulant activity.

Priority: HU19840004763 Applic. Date: 1984-12-21

Inventor: BAJUSZ SANDOR [HU]; SZELL NEE HASENOEHRL ERZSBET [HU]; BAGDY DANIEL [HU]; BARABAS EVA [HU]; DIOSZEGI MARIANN [HU]; FITTLER ZSUZSA [HU]; JOZSA FERENCZ [HU]; HORVATH GYULA [HU]; TOMORI NEE JOZST EVA [HU]


Patent No.: US4703762A  Issued: 03/Nov/1987

Title: Blood sampling device for obtaining dual samples of venous blood

Applicant/Assignee:

Application No.: 893002   Filing Date: 04/Aug/1986

Abstract:

This device is adapted for taking venous blood samples without the aid of any auxiliary negative pressure. Venous blood pressure is the sole force which fills the device with the blood sample. The device includes a flexible plastic tube formed from polyethylene or the like and further includes a blood drawing needle mounted on one end of the tube. A valved closure is disposed at the other end of the tube, the valve being operable to allow passage of air from the tube when the sample is drawn. The valve does not, however, allow the passage of blood from the tube. The tubes may be connected in tandem so as to allow the drawing of two samples with one venipuncture. The first tube can be devoid of an anti-coagulant coating while the second tube can include an anticoagulant coating. In this way, one drawn sample will be anti-coagulated and the other will not.

Priority:

Inventor: RATHBONE R RODION [US]; WARDLAW STEPHEN C [US]


Patent No.: US4705503A  Issued: 10/Nov/1987

Title: Metabolite sensor including a chemical concentration sensitive flow controller for a drug delivery system

Applicant/Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA

Application No.: 825211   Filing Date: 03/Feb/1986

Abstract:

A system for the measurement of a metabolite in a physiological fluid is disclosed which comprises a catheter which includes an internal metabolite sensor downstream from a semipermeable region where dynamic equilibrium is attained between the external metabolite and a higher concentration of the same metabolite contained in an infusate which is flowed through the catheter. The changing metabolite concentration also can open and close a chemical valve to control the codelivery of a drug through the catheter.

Priority:

Inventor: DORMAN FRANK D [US]; WIGNESS BRUCE D [US]


Patent No.: US4705756A  Issued: 10/Nov/1987

Title: Method of determining the existence and/or the monitoring of a pathological condition in a mammal

Applicant/Assignee: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

Application No.: 734799   Filing Date: 16/May/1985

Abstract:

A method of testing a cellular hematologic fluid derived from a mammal to determine the existence in the mammal of a pathological state or condition wherein an immunomodulator is admixed with the cellular hematologic fluid of the mammal and a reaction parameter determined and compared with known reaction parameters of cellular hematologic fluids of mammals of known healthy states to like immunomodulator. In a preferred embodiment of the present invention, the reaction parameter is a clotting parameter as determined as fibrin levels.

Priority: US1983-440540 Applic. Date: 1983-01-26

Inventor: SPILLERT CHARLES R [US]; SUVAL WILLIAM D [US]; LAZARO ERIC J [US]


Patent No.: US4708850A  Issued: 24/Nov/1987

Title: Self-contained portable apparatus for blood typing

Applicant/Assignee:

Application No.: 735616   Filing Date: 20/May/1985

Abstract:

A plurality of ampules, individually formed, filled with reagents, sealed with a pane and marked with indicia for reagents to be mixed with blood in performing tests to determine blood type groups is disclosed. A receptacle for a blood sample which conveys the blood sample to the ampules and which accomodates a plurality of the ampules is also disclosed along with a means for rupturing each pane.

Priority:

Inventor: HUSAIN ABBAS [US]


Patent No.: US4713176A  Issued: 15/Dec/1987

Title: Plasmapheresis system and method

Applicant/Assignee: HEMASCIENCE LABORATORIES, INC

Application No.: 722800   Filing Date: 12/Apr/1985

Abstract:

A reliable flow rate plasmapheresis system includes a rotating enhanced vortex of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in response thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starting anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.

Priority:

Inventor: SCHOENDORFER DONALD W [US]; HANSEN LEE E [US]


Patent No.: US4717660A  Issued: 05/Jan/1988

Title: Detection of bacteria by fluorescent staining in an expanded buffy coat

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 573988   Filing Date: 26/Jan/1984

Abstract:

A method for the detection of microorganisms e.g. bacteria in a blood sample comprises staining the microorganisms with a fluorescent dye and observing the fluorescence emission of an expanded buffy coat. The expanded buffy coat is obtained by centrifuging the stained sample in a hematocrit tube containing a float which occupies most of the buffy coat volume. The expanded buffy coat further separates into sub-layers. Intracellular microorganisms congregate in and are detected in the granulocyte sub-layer. The method may be modified to assess phagocytic activity.

Priority:

Inventor: SCHULTE THOMAS H [US]


Patent No.: US4728430A  Issued: 01/Mar/1988

Title: Diafiltration method

Applicant/Assignee: MILLIPORE CORPORATION

Application No.: 828105   Filing Date: 10/Feb/1986

Abstract:

A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation: +TR called Equation 1.

Priority:

Inventor: DILEO ANTHONY J [US]; DE LOS REYES GASTON [US]; WARANCH LISA M [US]


Patent No.: US4732891A  Issued: 22/Mar/1988

Title: Placenta-derived anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component

Applicant/Assignee: KOWA CO., LTD

Application No.: 909296   Filing Date: 19/Sep/1986

Abstract:

Novel human placenta-derived anticoagulating substances having the following properties: (1) molecular weight of 34,000+/-2,000 determined by SDA-polyacrylamide gel electrphoresis under reduced state

(2) isoelectric point of 4.7+/-0.1 determined by isoelectric column electrophoresis using an ampholite

(3) stability inactivated by heat treatment at 50 DEG C. to 30 minutes, stable at a pH of 4-10, and stable in plasma at 37 DEG C. for 30 minutes

(4) activity capable of prolonging a recalcification time, a prothrombin time, and an activated partial thromboplastin time

and (5) the existence of several amino acids including aspartic acid, threonine, serine, and so on

are prepared by homogenizing human placenta, subjecting the resulting homogenate to centrifugal separation, extracting an anticoagulating substance from the residue or from a microsome fraction contained in the supernatant with a surface active agent and/or a chelating agent, and purifying and isolating the substance from the extract. The anticoagulating substances have a high anticoagulating activity and exhibit a higher activity in the state where the tissue thromboplastin activity is exacerbated or in the state of exacerbating the coagulation. Hence, the anticoagulant containing the substance as an effective component has reduced side effects and is thus harmless.

Priority: JP19850217512 Applic. Date: 1985-09-30

Inventor: MAKI MASAHIRO [JP]; TANI HIDEO [JP]


Patent No.: US4735832A  Issued: 05/Apr/1988

Title: Container made of synthetic resin and method for manufacture thereof

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 18051   Filing Date: 24/Feb/1987

Abstract:

A container made of synthetic resin and provided at one portion thereof with at least one tightly closable opening, which container has on a surface thereof a continuous coating having a gas barrier characteristic comprising low permeability to oxygen and carbon dioxide by the plasma treatment reaction of a mixture of a silicon compound having the general formula I with a silicon compound having the general formula II: wherein m=1-5, n=1-5, R1 and R2 are C1-C5 alkyl, C1-C5 alkoxy or phenyl or OH.

Priority: JP19840092933 Applic. Date: 1984-05-11; JP19840092934 Applic. Date: 1984-05-11; JP19840092935 Applic. Date: 1984-05-11; JP19840092936 Applic. Date: 1984-05-11

Inventor: ICHIKAWA TOSHIJI [JP]; ASADA YOSHIMITSU [JP]; TATEBE KEN [JP]; TAKAHASHI TOORU [JP]; AOYAGI JUURO [JP]; SHIMOMURA TAKESHI [JP]


Patent No.: US4745053A  Issued: 17/May/1988

Title: Process for producing human interferon and method for assaying the interferon productivity of blood

Applicant/Assignee: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYOJO

Application No.: 624752   Filing Date: 26/Jun/1984

Abstract:

A process for producing HuIFN using whole human blood and a method for assaying the blood interferon (HuIFN) productivity are disclosed. The whole blood is incubated in the presence of an anticoagulant (e.g. heparin, ACD, and CPD) and a viral inducer under the conditions appropriate to accumulate a substantial amount of HuIFN. The blood HuIFN productivity determined by titrating the accumulated HuIFN with a suitable procedure (bioassay, radioimmunoassay, or enzyme-linked immunosorbent assay) is useful in clinical test to detect cancer in its early stage. The HuIFN per se is recovered, and purified prior to its prophylactic and therapeutic uses.

Priority: JP19830125152 Applic. Date: 1983-07-08; JP19830125153 Applic. Date: 1983-07-08

Inventor: MITSUHASHI MASAKAZU [JP]


Patent No.: US4755379A  Issued: 05/Jul/1988

Title: Polymers substituted by groups conferring anti-coagulant properties on them, process for their preparation, articles and compositions made therefrom and uses thereof

Applicant/Assignee:

Application No.: 781203   Filing Date: 27/Sep/1985

Abstract:

Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X denotes the group -SO3R1 or -R3-SO3R1, R1 being a hydrogen atom or a physiologically compatible metal, R3 being a -CH2-CO-NH-R4 group in which R4 represensts an alkyl aryl or alkylaryl radical, which may or may not be substituted, or substituted or unsubstituted -CH2-

Y denotes the group -SO2 -R2 or -R3 -SO2-R2, R2 being the residue of an amino acid connected to the -SO2 bridge through its amine function and V denotes the group -CH2-CO-NH-CHR-COOH, R being the side chain of an amino acid it being understood that: (a) if X is -SO3 R1 it is necessarily accompanied by Y and/or by V, and (b) V is always accompanied by X and/by Y.

Priority: FR19790018780 Applic. Date: 1979-07-20

Inventor: JOZEFONVICZ MARCEL [FR]; JOZEFONVICZ JACQUELINE [FR]; FOUGNOT CHRISTINE [FR]; MAUZAC MONIQUE [FR]


Patent No.: US4757057A  Issued: 12/Jul/1988

Title: Oligo-heteropolysaccharides having a heparin-like activity method for their preparation and pharmaceutical compositions based thereon

Applicant/Assignee: HEPAR CHIMIE S.A

Application No.: 816838   Filing Date: 07/Jan/1986

Abstract:

A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.

Priority: IT19770026608 Applic. Date: 1977-08-09

Inventor: FUSSI FERNANDO [IT]; FEDELI GIANFRANCO [IT]


Patent No.: US4769001A  Issued: 06/Sep/1988

Title: Method and apparatus for calibrating plural pump fluid flow system

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 802330   Filing Date: 27/Nov/1985

Abstract:

A blood constituent processing system uses a disposable plastic fluid flow path into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path are then monitored and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path. The relative pump flow control required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar arrangement may be used to derive relative flow calibration constants for the blood pump and a packed cell pump also present in the blood constituent processing system.

Priority: WO1987US00354 Applic. Date: 1987-02-25

Inventor: PRINCE PAUL R [US]


Patent No.: US4784157A  Issued: 15/Nov/1988

Title: Method and apparatus for taking samples from or administering medication to a patient

Applicant/Assignee:

Application No.: 7678   Filing Date: 28/Jan/1987

Abstract:

A controlled apparatus for withdrawing fluids from a patient or for administering medication to a patient, or both, which controlled apparatus may be remotely and/or automatically controlled. The apparatus includes a manifold and cannula for connecting the manifold to a patient, one or more syringes connected to the manifold, a pump for pumping liquid into and out of the manifold and a controller for controlling the operation of the syringes and the pump. A method of using the apparatus is also provided. The controlled apparatus is especially useful for the programmed withdrawal of blood from a blood vessel of a patient.

Priority: GB19860002732 Applic. Date: 1986-02-04

Inventor: HALLS JUSTIN A T [GB]; HAWES DAVID W [GB]; WOLFF HEINZ S [GB]; VAHRMAN RICHARD D [GB]


Patent No.: US4784946A  Issued: 15/Nov/1988

Title: Method for assaying the gamma-interferon productivity of blood

Applicant/Assignee: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

Application No.: 809756   Filing Date: 17/Dec/1985

Abstract:

Production of HuIFN-gamma and assay of blood HuIFN-gamma productivity both using donated blood are disclosed. Human whole blood secrets a high titer of HuIFN-gamma when exposed to an IFN-gamma inducer (e.g. mitogen) in the presence of anticoagulant (e.g. heparin, ACD, and CPD). Blood HuIFN-gamma productivity is determined by titrating the secreted HuIFN-gamma with a suitable procedure (e.g. bioassay, radio-immunoassay, or enzyme-linked immunosorbent assay). The blood of cancer patient is lower in HuIFN-gamma productivity than that of healthy donor. The HuIFN-gamma per se is recovered and purified prior to its prophylactic and therapeutic uses.

Priority: JP19840280697 Applic. Date: 1984-12-30; JP19840280698 Applic. Date: 1984-12-30

Inventor: MITSUHASHI MASAKAZU [JP]


Patent No.: US4800879A  Issued: 31/Jan/1989

Title: Disposable vascular occluder

Applicant/Assignee:

Application No.: 71406   Filing Date: 09/Jul/1987

Abstract:

A disposable vascular occluding device for temporarily stopping or interrupting blood flow in veins or arteries of the body during vascular surgery and emergency trauma surgery is constructed with two plastic arms connected at one end by a hinge for pivoting the arms towards and away from each other and connected at an end opposite the hinged end by a toothed latch for releasably securing the plastic arms in a closed position with inner surfaces thereof confronting each other. The inner surfaces of the plastics arms have semi-circular cavities formed therein which are shaped to conform to the blood vessel to be occluded. The inner surfaces of the plastic arms are lined by a pair of partially-inflated soft plastic balloons, centered in the cavities, one of which is further inflatable by means of an ordinary syringe through a valve in one of the plastic arms. The device facilitates occlusion of a blood vessel with minimal or no traumatization of the wall of the blood vessel.

Priority:

Inventor: GOLYAKHOVSKY VLADIMIR [US]; LERNER ROBERT [US]


Patent No.: US4801428A  Issued: 31/Jan/1989

Title: Blood sample sedimentation test kit

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 923365   Filing Date: 27/Oct/1986

Abstract:

A test kit is provided for measuring the erythrocyte sedimentation rate automatically in the original blood collection tube which is of a size and is so modified to be used for the resulting testing that no further blood transfer is required. The blood collection tube is evacuated to the desired level to obtain the desired quantity of blood to be collected and contains the proper quantity of anticoagulant. The test kit of the invention includes one or more tube-like slots for maintaining the blood collection tubes stable and in a vertical orientation for the testing procedure. Each slot includes a tube sleeve vertically adjustable in each slot. Each sleeve includes an appropriate Westergren scale which is moved with the sleeve to accommodate the positioning of the initial top level of the red blood cells in the sample.

Priority:

Inventor: HOMOLKO JOHANNES [FR]; DADER PIERRE T [FR]; ASSIER BERNARD [FR]


Patent No.: US4801452A  Issued: 31/Jan/1989

Title: Fibrinolytic composition

Applicant/Assignee:

Application No.: 45459   Filing Date: 07/May/1987

Abstract:

In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.

Priority: US1986-863582 Applic. Date: 1986-05-15

Inventor: HUNTER ROBERT L [US]; DUNCAN ALEXANDER [US]


Patent No.: US4804363A  Issued: 14/Feb/1989

Title: Apparatus and method for storing and processing blood

Applicant/Assignee: AUTOLOGOUS BLOOD CORPORATION

Application No.: 886196   Filing Date: 16/Jul/1986

Abstract:

This disclosure relates to a blood processing and preservation system. Apparatus of the system comprises a primary collection bag, a blood collection tube connected to the bag and adapted to draw a unit of blood from a person and feed the blood into the bag, and a harness connected to the bag for conducting solutions and blood components into and out of the bag. The harness includes a first tube for removing at least one blood component from the bag while retaining another component, a second tube for moving a cryoprotective solution into and out of the bag, a third tube for conducting a wash solution into and out of the bag, and identification on the bag. The foregoing apparatus is usable in a blood system including the method steps of collecting a unit of blood from a person and delivering the blood to the collection bag, processing the blood to separate the components and removing the components except for the red blood cells from the bag, preparing the red blood cells for freezing by conducting a cryoprotective solution into the bag and mixing this solution with the red blood cells, preserving the red blood cells by freezing, subsequently washing the red blood cells by conducting a wash solution and the cells into and out of the bag, and delivering the cells in the same collection bag to a recipient. While the foregoing method may be used in a homologous blood system where the recipient is not the donor, it is especially suited for use in an autologous blood system where the blood is reinfused in the person who furnished the blood, and the identification on the bag assures the recipient that he/she is receiving his/her own blood. Other blood components, such as the plasma, may also be preserved by freezing.

Priority:

Inventor: VALERI CESARE R [US]


Patent No.: US4806247A  Issued: 21/Feb/1989

Title: Plasmapheresis system and method

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 79108   Filing Date: 29/Jul/1987

Abstract:

A reliable flow rate plasmapheresis system includes a rotating enhanced vortex type of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in responses thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starging anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.

Priority: US1985-722800 Applic. Date: 1985-04-12

Inventor: SCHOENDORFER DONALD W [US]; HANSEN LEE E [US]


Patent No.: US4808161A  Issued: 28/Feb/1989

Title: Pressure-measurement flow control system

Applicant/Assignee:

Application No.: 22167   Filing Date: 05/Mar/1987

Abstract:

A system is provided for controlling flow of a first fluid through a line. Dispensing means isolates a region of the first fluid in the line from effects of pressure in the line outside of the region and repetitively dispenses into and out of the region volume increments of first fluid. Measurement fluid housing means houses measurement fluid in communication with the region such that the dispensing of increments of first fluid into or out of the region causes a change in the measurement fluid pressure. Displacement means displaces a predetermined volume increment of measurement fluid into and out of the measurement fluid housing means, such that displacement of the predetermined volume increment causes a change in the measurement fluid pressure when the region is isolated by the dispensing means. Pressure measurement means measures changes in measurement fluid pressure. Control means, in communication with the pressure measurement means, the displacement means, and the dispensing means, causes the dispensing means to dispense first fluid in increments based on data from the pressure measurement means, such that at least one of the predetermined volume increments of measurement fluid displaced serves as a reference for the volume increments of first fluid outputted.

Priority: US1986-836023 Applic. Date: 1986-03-04

Inventor: KAMEN DEAN L [US]


Patent No.: US4808449A  Issued: 28/Feb/1989

Title: Method for applying a dried coating of biologicals to the interior of a container

Applicant/Assignee: SHERWOOD MEDICAL COMPANY

Application No.: 900193   Filing Date: 25/Aug/1986

Abstract:

Containers such as syringes can be coated on their interior surface with biologicals such as heparin by atomizing the biological inside the container and reducing the pressure within the container for a period of time sufficient to allow the atomized biological to "auto-freeze" dry.

Priority:

Inventor: MCALISTER GARY B [US]


Patent No.: US4812310A  Issued: 14/Mar/1989

Title: Preserving solution for blood or packed blood cells and method for preserving blood or packed blood cells by using the same

Applicant/Assignee:

Application No.: 88450   Filing Date: 24/Aug/1987

Abstract:

A preserving solution for blood or packed blood cells comprising an anticoagulant solution containing citric acid, sodium citrate and glucose

an effective amount of glycerin

and an effective amount of mannitol. The use of the blood preserving solution makes it possible to preserve blood at a low temperature of from the freezing temperature of plasma (about -1 DEG C.) to 3 DEG C. and to extend the period of preservation to 4 or 5 weeks without any further special additives.

Priority: JP19860204269 Applic. Date: 1986-08-29

Inventor: SATO TORU [JP]; OKAZAKI NAOTO [JP]; HIYOSHI KATSUMI [JP]


Patent No.: US4813423A  Issued: 21/Mar/1989

Title: Instrument for measuring living body components

Applicant/Assignee: MITSUBISHI RAYON COMPANY LTD

Application No.: 52903   Filing Date: 22/May/1987

Abstract:exchange-document system="ops.epo.org" family-id="17962236" country="US" doc-number="4813423" kind="A"> US 4813423 A 19890321 US4813423 19890321 US19870052903 19870522 052903 JP19860306870 19861223 61-306870 MITSUBISHI RAYON CO [JP] MITSUBISHI RAYON COMPANY LTD MIYASAKA KATSUYUKI [JP] KATAYAMA MASAO [JP] YAMAMORI HISAYOSHI [JP] UCHIDA TERUYOSHI [JP] TASHITA JUNICHI [JP] OOE AKIHIKO [JP] WATANABE YOUJIROU [JP] MIYASAKA, KATSUYUKI, KATAYAMA, MASAO, YAMAMORI, HISAYOSHI, UCHIDA, TERUYOSHI, TASHITA, JUNICHI, OOE, AKIHIKO, WATANABE, YOUJIROU Instrument for measuring living body components

Priority: JP19860306870 Applic. Date: 1986-12-23

Inventor: MIYASAKA KATSUYUKI [JP]; KATAYAMA MASAO [JP]; YAMAMORI HISAYOSHI [JP]; UCHIDA TERUYOSHI [JP]; TASHITA JUNICHI [JP]; OOE AKIHIKO [JP]; WATANABE YOUJIROU [JP]


Patent No.: US4814247A  Issued: 21/Mar/1989

Title: Method for determining the existance and/or the monitoring of a pathological condition in a mammal

Applicant/Assignee: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

Application No.: 34101   Filing Date: 16/Mar/1987

Abstract:

PCT No. PCT/US86/01075 Sec. 371 Date Mar. 16, 1987 Sec. 102(e) Date Mar. 16, 1987 PCT Filed May 16, 1986 PCT Pub. No. WO86/06840 PCT Pub. Date Nov. 20, 1986.There is disclosed a method of testing a cellular hematologic fluid derived from a mammal to determine the existence in the mammal of a pathological state or condition wherein an immunomodulator is admixed with the cellular hematologic fluid of the mammal and a reaction parameter determined and compared with known reaction parameters of cellular hematologic fluids of mammals of known healthy states to like immunomodulator. In a preferred embodiment of the present invention, the reaction parameter is a clotting parameter as determined as fibrin levels.

Priority: US1983-440540 Applic. Date: 1983-01-26; US1985-734799 Applic. Date: 1985-05-16

Inventor: SPILLERT CHARLES R [US]; SUVAL WILLIAM A [US]; LAZARO ERIC J [US]


Patent No.: US4824941A  Issued: 25/Apr/1989

Title: Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems

Applicant/Assignee:

Application No.: 149138   Filing Date: 25/Jan/1988

Abstract:

A new specific antibody to 5'-terminal mono-, di- or triphosphorylated (2'-5')adenyl-adenoisine oligonucleotides and a method of producing it have been found. The antibody can be used for the quantitative analysis of the oligonucleotides mentioned above in any one of the well known methods of immunological analysis.

Priority: GB19830006617 Applic. Date: 1983-03-10

Inventor: GORDON JULIAN [US]; MINKS MICHAEL A [ZA]


Patent No.: US4828543A  Issued: 09/May/1989

Title: Extracorporeal circulation apparatus

Applicant/Assignee:

Application No.: 847978   Filing Date: 03/Apr/1986

Abstract:

A method and apparatus for extracorporeal circulation and treatment of blood. The apparatus comprises means for circulating and for treating blood, with a control system for controlling the circulating means. The circulating means includes tubing that directs blood to and from a microporous membrane. An arterial pump controls the flow rate of blood entering the filter

a venous pump controls the flow rate of blood exiting the filter. The filter includes a sealed, ported chamber surrounding the membrane. The rate of filtration of components removed from the blood through the membrane is directly proportional to a transmembrane pressure. Display and input devices transmit information between the central processor and an operator who operates the apparatus. The display and input devices include a keypad and an alphanumeric display. Sensors measure pressures within the tubing, at the inlet and outlet of the filter. Fluid flow rate can be calculated from the speeds of the pumps. The control system includes a central processor that receives input data from the sensors and the pumps to regulate the apparatus. The central processor will regulate the venous pump to maintain a specified outflow rate. The central processor also will maintain a desired average transmembrane pressure while the venous pump rate remains constant. The central processor calculates the average transmembrane pressure based on the measured filter input and output pressures. The central processor regulates the arterial pump speed as necessary to achieve the desired transmembrane pressure, while the venous pump rate is held steady.

Priority:

Inventor: WEISS PAUL I [US]; GUEST WELDON S [US]


Patent No.: US4832684A  Issued: 23/May/1989

Title: Peritoneal membrane plasmapheresis

Applicant/Assignee:

Application No.: 60612   Filing Date: 11/Jun/1987

Abstract:

A process to remove large molecules from the body involves infusion of a plasmate solution containing a vasodialating drug into the peritoneal cavity and subseaquent drainage on a prescribed schedule combined with intravenous or subcutaneous administration of an anticoagulant (e.g., heparin).

Priority: US1986-874793 Applic. Date: 1986-06-13

Inventor: POPOVICH ROBERT P [US]; MONCRIEF JACK W [US]


Patent No.: US4836855A  Issued: 06/Jun/1989

Title: Additive of protein nature for hydraulic cements, mortars & concretes, and use thereof in the field construction

Applicant/Assignee: ABC BIO-INDUSTRIES

Application No.: 175673   Filing Date: 25/Mar/1988

Abstract:

The present invention relates to a novel additive for hydraulic cements, mortars and concretes, particularly for improving the mechanical strengths and the workability and for reducing sweating and segregation, which is characterized in that it is a protein hydrolysate having a pH less than or equal to 6, comprising substances selected from the group constituted by proteins, polypeptides, aminoacids and mixtures thereof, and obtained by treating 100 volumes of an aqueous composition containing at least one protein substance selected from the group constituted by proteins, polypeptides and mixtures thereof, with at least one bacterial strain producing lactic acid having a population greater than or equal to 102 germs/cm3, in the presence of 0.5 to 30 parts by weight of a source of carbon belonging to the family of carbohydrates, for at least 2 hours, at a temperature of between 0 DEG and 65 DEG C. and at a pH less than or equal to 6.

Priority: FR19830003365 Applic. Date: 1983-03-01

Inventor: CAILLAU PIERRE [FR]; MORGAN PAUL [FR]; DE VEAUCE CHARLES D C [FR]


Patent No.: US4846795A  Issued: 11/Jul/1989

Title: Blood bag system

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 283007   Filing Date: 08/Dec/1988

Abstract:

In a blood bag system for plasma transfusion and cell return including two or more blood bags containing anticoagulant and connected to a puncture needle through two or more branch tubes and a common main tube, a cell return port is connected to the branch and a breakable flow path closure is inserted in one branch tube adjacent the branch. When broken, the flow path closure allows fluid communication through the branch tube. Blood is first collected in the first blood bag, which bag is sealed when filled and separated from the system. Then, the flow path closure is manually broken to permit blood collection into the second blood bag.

Priority: JP19830098021U Applic. Date: 1983-06-27

Inventor: MINAGAWA YOSHINORI [JP]


Patent No.: US4850998A  Issued: 25/Jul/1989

Title: Method for wetting a plasmapheresis filter with anticoagulant

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 106089   Filing Date: 07/Oct/1987

Abstract:

A method of wetting a plasmapheresis filter with anticoagulant in a plasmapheresis system having a venepuncture needle, a plasma separation device connected in series by a fluid conduit, including operating the system such that an initial limited volume charge of anticoagulant is introduced into the conduit (for wetting the filter of the separation device) in advance of whole blood flowing from the donor towards to the separation device (and pushing the anticoagulant charge ahead of the whole blood into the separation device).

Priority:

Inventor: SCHOENDORFER DONALD W [US]


Patent No.: US4853227A  Issued: 01/Aug/1989

Title: Transdermal administration of a systemic active agent to a premature neonatal infant

Applicant/Assignee: CIBA-GEIGY CORPORATION

Application No.: 112917   Filing Date: 23/Oct/1987

Abstract:

A method of treating a premature neonatal infant of a gestational age between about 24 and about 35 weeks with a pharmaceutically acceptable, systemically active, substantially skin compatible, water-soluble neonatal therapeutic agent having a molecular weight below about 5000, and which agent is substantially non-transmissable through normal mature intact human skin, comprising: (a) applying to the intact neonatal skin of said infant a transdermal device comprising (i) a backing member, (ii) a substantially shape retaining hydrogel reservoir having a water content of between about 5 percent and about 95 percent preferably between 10 percent and 80 percent by weight of said reservoir and containing an effective amount of said agent, (iii) a skin contacting surface of predetermined area, and (iv) means for maintaining said reservoir in material transmitting relationship to said skin

(b) maintaining said skin contacting surface of said device in material transmitting relationship to said intact neonatal skin of the infant for an extended period of time

and (c) delivering said agent through the intact neonatal skin in a controlled continuous manner such that the blood plasma level of said agent is substantially within the therapeutic index of said agent for a majority of said extended period of time.

Priority:

Inventor: KURIHARA-BERGSTROM TAMIE [US]; GOOD WILLIAM R [US]; EBERT CHARLES D [US]


Patent No.: US4877741A  Issued: 31/Oct/1989

Title: Treatment of human plasma with brown recluse spider toxin to emulate a lupus anticoagulant

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE

Application No.: 261302   Filing Date: 24/Oct/1988

Abstract:

A new method for improving the accuracy of blood tests for the presence of lupus anticoagulants and for blood factor deficiencies is disclosed. Brown recluse spiders are collected, their venon glands removed by microdissection and the active toxin extracted. The toxin is mixed with normal donor plasma in concentrations of about 3.5 mu l/ml of toxin to plasma. The treated plasma successfully mimics human plasma having lupus anticoagulants. By using the treated plasma in blood tests and assays as a standardized control to which the results from tests on questioned blood plasma samples may be compared, the equipment and procedures for those tests may be calibrated and test results made more sensitive and reliable.

Priority:

Inventor: BABCOCK JAMES L [US]; MCGLASSON DAVID L [US]


Patent No.: US4880602A  Issued: 14/Nov/1989

Title: Method and device for disinfecting biological fluids and container for same

Applicant/Assignee:

Application No.: 58553   Filing Date: 05/Jun/1987

Abstract:exchange-document system="ops.epo.org" family-id="25120285" country="US" doc-number="4880602" kind="A"> US 4880602 A 19891114 US4880602 19891114 US19870058553 19870605 058553 US19850780668 19850929 780,668 AL SIOUFI HABIB [US] AL-SIOUFI, HABIB AL-SIOUFI HABIB [US] AL-SIOUFI, HABIB Method and device for disinfecting biological fluids and container for same

Priority: US1985-780668 Applic. Date: 1985-09-29

Inventor: AL-SIOUFI HABIB [US]


Patent No.: US4886487A  Issued: 12/Dec/1989

Title: Autotransfusion apparatus

Applicant/Assignee: GAMBRO AB

Application No.: 932173   Filing Date: 18/Nov/1986

Abstract:

Autotransfusion apparatus is disclosed for employing a patient's blood as a source for providing a transfusion, and which can also supply anticoagulant and diluting solution to the blood collected from a patient. The apparatus including a cardiotomy reservoir for collecting the patient's blood, a blood filter for separating a filtrate from the blood, a blood retention bag for retaining the treated blood and from which the blood can be returned to the patient by gravity.

Priority: SE19850005438 Applic. Date: 1985-11-18

Inventor: SOLEM JAN O [SE]; PILMAN OLEV [SE]


Patent No.: USRE32056E  Issued: 24/Dec/1985

Title: Method of forming a connection between two sealed conduits using radiant energy

Applicant/Assignee:

Application No.: US 1981-271907   Filing Date: 09/Jun/1981

Abstract:exchange-document system="ops.epo.org" family-id="26955184" country="US" doc-number="RE32056" kind="E"> US RE32056 E 19851224 USRE32056E 19851224 US19810271907 19810609 US19810271907 19810609 US19770843608 19771019 Method of forming a connection between two sealed conduits using radiant energy

Priority: US1977-843608 Applic. Date: 1977-10-19

Inventor:


Patent No.: USRE32874E  Issued: 21/Feb/1989

Title: Plasma-free medium for platelet storage

Applicant/Assignee:

Application No.: US 1986-860894   Filing Date: 08/May/1986

Abstract:exchange-document system="ops.epo.org" family-id="4123856" country="US" doc-number="RE32874" kind="E"> US RE32874 E 19890221 USRE32874E 19890221 US19860860894 19860508 CA19820414583 19821101 Plasma-free medium for platelet storage

Priority: CA19820414583 Applic. Date: 1982-11-01

Inventor:


Patent No.: US4898572A  Issued: 06/Feb/1990

Title: Autotransfuser

Applicant/Assignee: FUTUR-QUOTIDIEN S.A

Application No.: 127053   Filing Date: 01/Dec/1987

Abstract:

An autotransfuser device for removing blood from a patient and returning the blood to the patient includes a collection bag suspended in an air jacket. A valve is provided in the device to selectively apply a negative pressure to the air jacket and the interior of the collection bag to draw the blood from the patient. The valve is subsequently rotated to apply a positive pressure to the air jacket and the outside of the bag to compress the bag and cause the blood to be returned to the patient. A plurality of filter members are provided in a collection chamber to remove blood clots and undesirable solids. A source of an anticoagulant may be provided in the collection chamber and in the collection bag.

Priority: FR19860009117 Applic. Date: 1986-06-24

Inventor: SURUGUE NEE LASNIER EVELYNE [FR]; LASNIER HUBERT [FR]; PEROVITCH PHILLIPE [FR]


Patent No.: US4898573A  Issued: 06/Feb/1990

Title: Blood components collector unit

Applicant/Assignee: ASAHI MEDICAL CO., LTD

Application No.: 114020   Filing Date: 29/Oct/1987

Abstract:

There is disclosed a blood components collector unit comprising a cannula, a blood collection bag and a membrane type blood components separator which are connected in this order through tubes, and also comprising a plasma collection reservoir and a blood cell collection reservoir, both of which are connected to the blood components separator through tubes, wherein each connection through each tube is in a fixed fashion, thereby providing a unified connection, and wherein the blood collector unit is packed in a container in a sterile state. By the use of the unit of the present invention, whole blood can be collected and separated into blood components easily at a shortened period of time without any cumbersome preparatory operations. In addition, since the unit of the present invention is compact and light in weight and can be used without any other auxiliary apparatus, the unit can be conveyed to and used in any places, such as in automobiles and outdoors. Further, the time of restraining a whole blood donor can be decreased, leading a less burdening of the donor with a great advantage.

Priority: JP19870216517 Applic. Date: 1987-09-01; JP19860255922 Applic. Date: 1986-10-29

Inventor: TAKENAKA YOSHINORI [JP]; FUKUMI HIROKAZU [JP]; SEKIGUCHI SADAYOSHI [JP]


Patent No.: US4898675A  Issued: 06/Feb/1990

Title: System and method for continuously fractionating blood in situ

Applicant/Assignee:

Application No.: 809923   Filing Date: 15/Dec/1985

Abstract:

A system, method and device for continuously fractionating blood in situ. The fractionating device is connected in a closed loop to the donor and includes interleaved blood plates and blood fraction plates separated by a semipermeable membrane. Grooves in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates and intraplate is obtained by manifolds. The input and output pressures of the blood pump are sensed and inputed to an microprocessor, into which donor data including weight, sex, and hematocrit is also keyed by the user. The microprocessor operates under program control to calculate, based on the donor data, the amount of plasma to be collected and the amount of anticoagulant to be added. The program controls the operation of the extracorporeal devices, regulates the operating parameters, and stops the procedure when the predetermined amount of plasma has been obtained.

Priority: US1983-523007 Applic. Date: 1983-08-15

Inventor: LAVENDER ARDIS R [US]


Patent No.: US4900679A  Issued: 13/Feb/1990

Title: Method for determining the existence and/or the monitoring of a pathological condition in a mammal and a test kit therefor

Applicant/Assignee: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

Application No.: 236039   Filing Date: 23/Aug/1988

Abstract:

There is disclosed a method of testing, and a kit therefor, a cellular hematologic fluid derived from a mammal to determine the existence in the mammal of a pathological state or condition wherein an immunomodulator is admixed with the cellular hematologic fluid of the mammal and a reaction parameter determined and compared with known reaction parameters of cellular hematologic fluids of mammals of known healthy states to like immunomodulator. In a preferred embodiment of the present invention, the reaction parameter is a clotting parameter as determined as fibrin levels.

Priority: US1983-440540 Applic. Date: 1983-01-26; US1983-538783 Applic. Date: 1983-10-04; US1985-734799 Applic. Date: 1985-05-16

Inventor: SPILLERT CHARLES R [US]; SUVAL WILLIAM A [US]; LAZARO ERIC J [US]


Patent No.: US4911703A  Issued: 27/Mar/1990

Title: Mobile, self-contained blood collection system and method

Applicant/Assignee: BAXTER INTERNATIONAL INC AMERICAN NATIONAL RED CROSS

Application No.: 296850   Filing Date: 12/Jan/1989

Abstract:

Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood froma donor

forcing the collected blood unit through a plasma separator

accumulating the plasma in a container

and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.

Priority: US1986-919346 Applic. Date: 1986-10-15

Inventor: LYSAGHT MICHAEL J [US]; BOGGS DANIEL R [US]; RITGER PHILIP L [US]; STROMBERG ROBERT R [US]; FRIEDMAN LEONARD I [US]


Patent No.: US4912092A  Issued: 27/Mar/1990

Title: Methods for increasing extracellular adenosine and for stabilizing mast cells

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 79657   Filing Date: 29/Jul/1987

Abstract:

Methods for increasing extracellular concentrations of adenosine for the prophylactic or affirmative treatment of diseases of the immune, nervous, cardiac, and vascular systems involving admimistering to a patient purine nucleoside and purine nucleoside-related analogs which increase extracellular adenosine concentration, and methods for stabilizing mast cells by the suppression of mast cell activation using such compounds.

Priority: US1986-845627 Applic. Date: 1986-03-27

Inventor: GRUBER HARRY E [US]


Patent No.: US4917801A  Issued: 17/Apr/1990

Title: Lymphocyte collection tube

Applicant/Assignee: BECTON DICKINSON AND COMPANY

Application No.: 117396   Filing Date: 02/Nov/1987

Abstract:

This invention relates to an assembly for centrifugally separating lymphocytes and monocytes from the heavier phases in samples of human blood utilizing a liquid density gradient medium. The particular inventive subject matter concerns the use of novel partition means initially separating the liquid density gradient medium from the sample of blood and designs for such partition means.

Priority: US1984-678100 Applic. Date: 1984-12-04; US1986-864443 Applic. Date: 1986-05-16

Inventor: LUDERER ALBERT A [US]; SMITH WARD C [US]


Patent No.: US4919817A  Issued: 24/Apr/1990

Title: Blood cell washing systems and methods

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 159446   Filing Date: 18/Feb/1988

Abstract:

A system and method for cleaning contaminants from shed blood to enable reinfusion of a cell concentrate in the patient employs successive rotary membrane filtering stages in which Taylor vortices are generated. Shed blood led into the first rotary membrane stage is filtered to a hematocrit in the range of 50-60 with some of the waste matter being removed. The intermediate cell concentrate is passed to the second filter stage where further waste matter is initially extracted. At any intermediate region, however, a major amount of wash solution is fed into the concentrate and effectively mixed by the Taylor vortices. In the remaining length of the second filter stage waste matter is entrained in wash solution and both waste and wash solution are filtered out to provide a cell concentrate from which the great majority of contaminants have been removed.

Priority: US1986-895505 Applic. Date: 1986-08-11

Inventor: SCHOENDORFER DONALD W [US]; WILLIAMSON LEE H [US]


Patent No.: US4922910A  Issued: 08/May/1990

Title: Cannula having an electrode

Applicant/Assignee: AISIN SEIKI SHIN SANGYO KAIHATSU KK

Application No.: 241276   Filing Date: 07/Sep/1988

Abstract:

A cannula has an electrode therein for detecting electrocardiographic signals. The electrode is located in the inner wall of the cannula and has anti-thrombus characteristics. The electrode comprises a composition of an anti-thrombus polyurethane powder and a carbon powder. This composition has electrically conductive and anti-thrombus characteristics. The electrode is located in a recess of the inner wall of the cannula. The electrode is connected to the outside through a wire conductor.

Priority: JP19870223719 Applic. Date: 1987-09-07

Inventor: KANAI NARITOSHI [JP]; SUZUKI AKIRA [JP]


Patent No.: US4923449A  Issued: 08/May/1990

Title: Apparatus for collecting constant amounts of blood from individual donors

Applicant/Assignee: TIYODA SEISAKUSHO KK KAWASUMI LAB INC

Application No.: 122025   Filing Date: 18/Nov/1987

Abstract:

An apparatus for the collection of blood via a collapsible inflow pipe into an inflatable bag having an anticoagulant prefilled therein. The bag is placed on a weighing platform coupled to a load cell, which produces an electric voltage signal representative of the weight of the blood being collected in the bag. The load cell is mounted on a swing cradle capable of oscillation about a horizontal axis, so that the bag is shaken during blood collection for intimately intermingling the collected blood and the anticoagulant. When a predetermined amount of blood is collected, as ascertained from the voltage output of the load cell, a controller actuates a collection stop mechanism thereby causing the same to tightly grip and collapse the inflow pipe.

Priority: JP19870074240 Applic. Date: 1987-03-30; JP19860176584U Applic. Date: 1986-11-19

Inventor: TOYA MATSUMI [JP]; MIYAIRI YASUYUKI [JP]


Patent No.: US4925665A  Issued: 15/May/1990

Title: Glucose free primary anticoagulant for blood containing citrate ions

Applicant/Assignee: THOMAS JEFFERSON UNIVERSITY

Application No.: 369842   Filing Date: 22/Jun/1989

Abstract:

The present invention provides a novel primary citrate anticoagulant which is essentially free of glucose and its use to optimize the viability of stored platelets. The present invention allows platelets to be stored in plasma or synthetic media without the addition of buffer. Specifically the anticoagulant consists essentially of sodium citrate and citric acid.

Priority:

Inventor: MURPHY SCOTT [US]


Patent No.: US4931002A  Issued: 05/Jun/1990

Title: Pyridoxal-5'-phosphate as an in vitro anticoagulant for whole blood

Applicant/Assignee: THE UNIVERSITY OF VERMONT

Application No.: 55637   Filing Date: 29/May/1987

Abstract:

The use of pyridoxal-5'-phosphate as an in vitro anticoagulant agent which retains the platelet activity of stored whole blood or stored plasma for more than about six hours is disclosed.

Priority:

Inventor: KORNECKI ELIZABETH H [US]; EHRLICH YIGAL H [US]


Patent No.: US4936310A  Issued: 26/Jun/1990

Title: Catheter for intravascular pressure measurement

Applicant/Assignee: RADISENSOR AB

Application No.: 341112   Filing Date: 20/Apr/1989

Abstract:

The invention relates to a catheter for intravascular pressure measurement. The catheter includes a leader (3) with a transducer (4). The leader is surrounded by an inner sheath (2) with a reduced partial section portion (6) and by an outer sheath (1) arranged around the inner sheath. An end closure (5) joins the outer and inner sheath to each other at the distal end of the catheter to form an outer cavity (9), intended to be pressurized by an outside pressure source, whereby the attenuated partial section sealingly surrounds the leader or transducer (4). Pressure calibration in situ is enabled with the aid of the inventive catheter.

Priority: SE19880001517 Applic. Date: 1988-04-22

Inventor: ENGSTROEM THOMAS [SE]; HOEK BERTIL [SE]; TENERZ LARS [SE]


Patent No.: US4938224A  Issued: 03/Jul/1990

Title: Process for detecting accidental contact with body fluids

Applicant/Assignee:

Application No.: 271922   Filing Date: 16/Nov/1988

Abstract:

A process for detecting accidental contact body fluid samples includes the addition of a small amount of a fluorescent chemical to the body fluid sample, the fluorescent chemical serving as a marker detectable upon exposure to ultraviolet light, Accordingly, any spills of the body fluid sample on exposed surfaces can be readily visually detected upon illuminating those surfaces with an ultraviolet light. Likewise, a process for detecting accidental exposure to a body fluid by skin surface protected by gloves or another substantially fluid impervious covering comprises submerging the gloved or otherwise covered skin surface into a fluorescent fluid, removing the glove or other covering and then illuminating the skin surface with an ultraviolet light to visually detect any fluorescent spots caused by holes or other leaks through the glove or other covering.

Priority:

Inventor: RYSAVY JOSEPH A [US]


Patent No.: US4938758A  Issued: 03/Jul/1990

Title: Anti-pathogenic blood collection system and method

Applicant/Assignee:

Application No.: 121338   Filing Date: 16/Nov/1987

Abstract:

A blood collection system and method are disclosed in which a neutralizing agent for pathogens such as HTLV-III virus is added to the blood collected in a standard blood bag or group of connected bags. Conveniently, the neutralizing agent, which can be in liquid or powder form, is held in a small container attached to the blood bag and released into the collected blood or alternatively, prepositioned in the collecting or satellite bag.

Priority: US1986-848923 Applic. Date: 1986-04-07

Inventor: AL-SIOUFI HABIB [US]


Patent No.: US4944883A  Issued: 31/Jul/1990

Title: Continuous centrifugation system and method for directly deriving intermediate density material from a suspension

Applicant/Assignee:

Application No.: 256234   Filing Date: 11/Oct/1988

Abstract:

A system for continuously separating lighter and intermediate density matter, such as plasma rich in platelets from whole blood moves blood through a diverging centrifugation gap between inner and outer walls of a rotor rotating about a central axis within an outer housing. The centrifugation action creates layered flow along an intermediate section. However by crating trailing wakes in the gap between the rotor and housing, localized remixing patterns tending to move in the opposite direction are induced in the layered matter. Platelet rich plasm may then be extracted through adjacent platelet concentrate ports on the inner wall of the rotor. An interior passageway system passes the platelet rich plasma to a platelet concentrate reservoir. Recirculation of blood in the rotor-housing gap between the output and input, and pumping action provided by the diverging centrifugation gap, aid in enhancing throughput and concentration levels. Prior to the centrifugation gap an initial narrow gap section is employed to limit backward propagation of the induced circulatory patterns.

Priority: US1987-002804 Applic. Date: 1987-01-13

Inventor: SCHOENDORFER DONALD W [US]; BERTHE CLAUDE E [US]


Patent No.: US4944918A  Issued: 31/Jul/1990

Title: Sterilization of blood component separation devices

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 144214   Filing Date: 15/Jan/1988

Abstract:

A method of sterilization is provided and a sterilized product from the method for blood separation tubes utilizing a density gradient medium comprised of ficoll and sodium diatrizoate alone or in combination with other such mediums by exposing such mediums to radiation sterilization from such sources as Cobalt 60 without any precipitation out of the components of the medium. This is achieved by the addition of a buffer to the gradient medium at a rate which will provide a specific pH level for the medium after exposure.

Priority:

Inventor: DESAI JAY S [US]


Patent No.: US4950256A  Issued: 21/Aug/1990

Title: Non-thrombogenic intravascular time release catheter

Applicant/Assignee: LUTHER MEDICAL PRODUCTS, INC

Application No.: 462911   Filing Date: 11/Jan/1990

Abstract:

An intravascular catheter comprising a cannula for insertion into a vascular system of a patient coated with hydrophilic polymer containing, in the polymer, an effective amount of polymyxin to prevent the growth of microorganisms is disclosed.

Priority: US1988-178621 Applic. Date: 1988-04-07

Inventor: LUTHER RONALD B [US]; SHANBROM EDWARD [US]


Patent No.: US4956278A  Issued: 11/Sep/1990

Title: Anaplasma marginale antigen, antigen compositions, vaccine and process for the production of said antigen, antigen compositions and vaccine

Applicant/Assignee: LOUISIANA STATE UNIVERSITY

Application No.: 159394   Filing Date: 23/Feb/1988

Abstract:

Anaplasma marginale antigen, antigen compositions, vaccine and process for the production of said antigen, antigen composition and vaccine are disclosed. The Anaplasma marginale is free of the erythrocyte antigens that cause neonatal isoerythrolysis, and effective as a vaccinate which will not only protect the vaccinate against bovine anaplasmosis, but does not induce neonatal isoerythrolysis in offspring of vaccinates.

Priority:

Inventor: HART LEWIS T [US]; LUTHER DONALD G [US]; TODD WILLIAM J [US]


Patent No.: US4960694A  Issued: 02/Oct/1990

Title: Test combination and method of detecting fibrin monomers in blood

Applicant/Assignee: STEPANAUSKAS LEGAL REPRESENTATIVE BY LEONAS-VITAS STEPANAUSKAS LEGAL REPRESENTATIVE DAINA THRUM LEGAL REPRESENTATIVE BY MARGOT THRUM LEGAL REPRESENTATIVE BY MATTHIAS THRUM LEGAL REPRESENTATIVE BY MICHAEL

Application No.: 71799   Filing Date: 09/Jul/1987

Abstract:

A test reagent for detecting fibrin monomers in blood, comprises an antibiotic of a pyrrole amidine series as a precipitant, introduced in a buffer solution. A method of detecting fibrin monomers in blood, comprises the steps of mixing venous blood with an anticoagulant, centrifuging the mixture of the venous blood with the anticoagulant, removing a citrate plasma, using an antibiotic of a pyrrole amidine series as a precipitant, and evaluating a precipitation reaction which takes place thereby.

Priority: DD19860292298 Applic. Date: 1986-07-09

Inventor: ECKARDT KLAUS [DD]; TOEPFER GOTTFRIED [DD]; SEIFERT ANDREAS [DD]; SCHULZE MANFRED [DD]; FUNKE UDO [DD]; STEPANAUSKAS MARLENA [DD]; STEPANAUSKAS LEGAL REPRESENTAT [DD]; STEPANAUSKAS LEGAL REPRESENTAT [DD]; THRUM HEINZ [DD]; THRUM LEGAL REPRESENTATIVE BY [DD]; THRUM LEGAL REPRESENTATIVE BY [DD]; THRUM LEGAL REPRESENTATIVE BY [DD]


Patent No.: US4968295A  Issued: 06/Nov/1990

Title: Method of separating the constituents of the blood

Applicant/Assignee: FRESENIUS AG

Application No.: 99289   Filing Date: 21/Sep/1987

Abstract:

The invention relates to the control of a system in a blood centrifuge for separating the constituents (fractions) of the whole blood taken from a donor "in vivo" and provided with anticoagulants. A control is provided which as input quantity includes a signal on the flow rate of the full blood and on the output side is connected to the speed setting means for the blood centrifuge. The transfer function of the control is so defined that on a change of the full blood flow the speed of rotation is set so that the volume ratios of the blood fractions to the full blood remain constant. Preferably, the output signal of the control is proportional to the square root of the full blood flow. The control is preferably formed by a microprocessor.

Priority: DE19863632176 Applic. Date: 1986-09-22

Inventor: NEUMANN HANS-JUERGEN [DE]


Patent No.: US4971953A  Issued: 20/Nov/1990

Title: Anticoagulant peptide alcohols

Applicant/Assignee: MERRELL DOW PHARMACEUTICALS

Application No.: 504719   Filing Date: 03/Apr/1990

Abstract:

This invention relates to peptide derivatives which are useful anticoagulant agents.

Priority: US1988-192409 Applic. Date: 1988-05-10

Inventor: KRSTENANSKY JOHN L [US]


Patent No.: US4976682A  Issued: 11/Dec/1990

Title: Methods and apparatus for autologous blood recovery

Applicant/Assignee:

Application No.: 272241   Filing Date: 16/Nov/1988

Abstract:

Improved methods and apparatus for the collection, purification and reinfusion of blood from a wound site. The present invention provides a source of anticoagulated washing fluid in proportion to the bleeding rate which can be directed to the suction tip in such a way that the wound or surgical site is washed. The present invention minimizes blood damage and maximizes blood recovery by (i) automatically regulating the suction in proportion to the bleeding rate, (ii) minimizing the air suction or blood frothing, (iii) washing the wound site with the anticoagulated washing fluid, and (iv) reducing the number of blood pumps, preferably to one. The present invention also provides a system to operate automatically by including automatic venting of entrapped air, continuous determination of irrigation fluid added into the wound site and its removal, continuous monitoring of hematocrit, continuous neutralization of anticoagulant, and reinfusion of purified blood to patient on realtime basis irrespective of bleeding rate.

Priority: US1987-123809 Applic. Date: 1987-11-23

Inventor: LANE PERRY L [US]; SHETTIGAR UDIPI R [US]


Patent No.: US4978446A  Issued: 18/Dec/1990

Title: Sterile blood component collection

Applicant/Assignee: COBE LABORATORIES, INC

Application No.: 467034   Filing Date: 18/Jan/1990

Abstract:

Apparatus for collecting blood components including a supply line that is connected to a blood line and has a filter on it to permit passage of supply solution (e.g., anticoagulant or saline prime) and blocks passage of bacteria.

Priority: US1987-089493 Applic. Date: 1987-08-26; US1989-322097 Applic. Date: 1989-03-10

Inventor: LOBDELL DONN D [US]


Patent No.: US4980054A  Issued: 25/Dec/1990

Title: System and method for mass transfer between fluids

Applicant/Assignee:

Application No.: 139647   Filing Date: 30/Dec/1987

Abstract:

A system, method and device for continuous mass transfer in fluids, such as blond. A mass transfer device is connected in a closed path between a blood source and a reservoir. Pumps and valves are provided to move the blood through the mass transfer device sequentially in a first path from the blood source to the reservoir and in a second pass from the reservoir to the blood source. Material may be added to the blood flowing from the source. The mass transfer device may be a fractionating device, In that case the system and method may be used for plasma collection, or for displacement of water preparatory to freezing of the blood, or for the formation of washed blood cells from either whole blood or thawed blood. The system and method may be used for hemodialysis, in which case the mass transfer device is a dialyzer. The fractionating device includes interleaved blood plates and blood fraction collection plates separated by semipermeable membranes. The device is arranged with two separate passages therethrough, each comprising a pair of parallel blood flow channels

the passages being connected in series by external tubing.

Priority: US1983-523007 Applic. Date: 1983-08-15; US1985-809923 Applic. Date: 1985-12-15

Inventor: LAVENDER ARDIS R [US]


Patent No.: US4980068A  Issued: 25/Dec/1990

Title: System, apparatus and method for continuously fractionating blood in situ

Applicant/Assignee:

Application No.: 523007   Filing Date: 15/Aug/1983

Abstract:

Priority:

Inventor: LAVENDER ARDIS R [US]


Patent No.: US4981596A  Issued: 01/Jan/1991

Title: System for treating blood for autotransfusion

Applicant/Assignee: GREEN CROSS CORPORATION

Application No.: 270328   Filing Date: 14/Nov/1988

Abstract:

Priority: JP19870288205 Applic. Date: 1987-11-13

Inventor: SHIINO SATORU [JP]; SHIMOTAKAHARA MASAKI [JP]; ISOZAKI TAKESI [JP]; MIMURA MASANOBU [JP]; TAKABAYASHI KUNIAKI [JP]; HASHIMOTO NORIKAZU [JP]


Patent No.: US4983586A  Issued: 08/Jan/1991

Title: Pharmaceutical formulations for parenteral use

Applicant/Assignee: UNIVERSITY OF FLORIDA

Application No.: 174945   Filing Date: 29/Mar/1988

Abstract:

Aqueous parenteral solutions of drugs which are insoluble or only sparingly soluble in water and/or which are unstable in water, combined with hydroxypropyl- beta -cyclodextrin, provide a means for alleviating problems associated with drug precipitation at the injection site and/or in the lungs or other organs following parenteral administration.

Priority: US1987-139755 Applic. Date: 1987-12-30

Inventor: BODOR NICHOLAS S [US]


Patent No.: US4985026A  Issued: 15/Jan/1991

Title: Blood collecting tube

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 387026   Filing Date: 28/Jul/1989

Abstract:

Priority: JP19880193608 Applic. Date: 1988-08-03

Inventor: KASAI MASAAKI [JP]; YAMAZAKI SAKAE [JP]; MIYAKE SANAE [JP]


Patent No.: US4985153A  Issued: 15/Jan/1991

Title: Method for separating blood into blood components, and blood components separator unit

Applicant/Assignee: ASAHI MEDICAL CO., LTD

Application No.: 370750   Filing Date: 23/Jun/1989

Abstract:

Priority: JP19880153464 Applic. Date: 1988-06-23; JP19880153465 Applic. Date: 1988-06-23

Inventor: KURODA TORU [JP]; NISHIMURA TAKAO [JP]


Patent No.: US4995863A  Issued: 26/Feb/1991

Title: Catheter with slit valve

Applicant/Assignee: CATHETER TECHNOLOGY CORPORATION

Application No.: 160473   Filing Date: 25/Feb/1988

Abstract:

Catheter tubes of elastomeric material having novel lumen shapes which prevent occlusion and accommodate continued liquid flow even when kinked. Also, catheter tube slit valves are disclosed, the walls of which are not chemically weakened. Symmetrical and asymmetrical versions of said slit valves are disclosed. Combinations of highly reliable slit valves and catheter tubes are disclosed. Independently operable multi-lumen catheter assemblies of synthetic material, such as silicone rubber are disclosed, wherein the distal end of each lumen is normally closed by a three-position slit valve formed in a catheter tube covering. Multi-lumen catheters, and related methods, are also disclosed wherein the lumens are internal at the proximal and distal ends of the catheter tube but comprise separate tubes in between whereby, following placement of the distal end of the catheter tube in the body cavity of a patient, the unified proximal end of the tube is manipulated, sometimes subcutaneously, with the ultimately exposed tubes being thereafter severed and each equipped with a hub at a convenient exposed body site for selective independent passage of influent and effluent liquid along each lumen.

Priority: US1986-915474 Applic. Date: 1986-10-06

Inventor: NICHOLS COLIN J [US]; NORDGREN GREGORY N [US]; MOOREHEAD HARVEY R [US]


Patent No.: US5002965A  Issued: 26/Mar/1991

Title: Use of ginkgolides to prevent reperfusion injury in organ transplantation

Applicant/Assignee: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

Application No.: 349035   Filing Date: 09/May/1989

Abstract:

A living tissue or living cell preservation solution comprising an effective amount of a ginkgolide to reduce reperfusion injury in living tissue which has been stored therein and a substance or mixture or substances present in an amount sufficient to produce an osmotic pressure in said solution approximately equal to the osmotic pressure or mammalian cell and a method for preventing or reducing reperfusion injury in transplanted mammalian organs, which comprises contacting an organ prior to reperfusion with an effective amount of a ginkgolide to reduce reperfusion injury in said organ.

Priority:

Inventor: RAMWELL PETER W [US]; FOEGH MARIE L [US]


Patent No.: US5009847A  Issued: 23/Apr/1991

Title: Kit for determining blood platelet stress

Applicant/Assignee:

Application No.: 844890   Filing Date: 27/Mar/1986

Abstract:

A kit is provided for measuring chemical and physical stresses on the blood platelets of a human patient by measuring reduction in ATP (adenosine triphosphate) and ADP (adenosine diphosphate) concentrations while measuring increases in the ATP degradation products HYPX (hypoxanthine) and the AMP (adenosine monophosphate). The kit is useful for measuring a human patient's risk to internal stress such as reduction in the size of blood vessels, to response to various environmental changes as well as to a variety of treatments including drug treatment, risk of malignant hyperthermia in response to anesthetic administration or in response to vascular or organ transplant.

Priority: US1984-623579 Applic. Date: 1984-06-22

Inventor: SOLOMONS CLIVE C [US]


Patent No.: US5011468A  Issued: 30/Apr/1991

Title: Retroperfusion and retroinfusion control apparatus, system and method

Applicant/Assignee: RETROPERFUSION SYSTEMS, INC

Application No.: 511930   Filing Date: 16/Apr/1990

Abstract:

Disposable pump cassette for a liquid comprising a substantially rigid housing providing a chamber and having upper and lower portions. A flexible substantially cylindrical bladder is vertically disposed in the chamber and has an inlet adapted to receive the liquid and an outlet. The bladder has upper and lower wall portions. The lower wall portion is of a thinner cross section then the upper wall portion. An inlet valve is disposed in the inlet of the bladder and is mounted in the lower portion of the housing. An outlet valve is disposed in the outlet of the bladder and is mounted in the upper portion of the housing. The inlet and outlet valves are disposed in the liquid and provide unidirectional flow of the liquid through the bladder. A substantially incompressible driving liquid is disposed in the chamber and surrounds the bladder. A housing extension is mounted on said housing and is in communication with the driving liquid disposed in the chamber. A movable piston is slidably mounted in the housing extension. A drive is provided for reciprocating the piston for causing displacement of the driving liquid in the chamber to compress and decompress the bladder to cause the liquid to flow through the bladder progressively from the lower portion to the upper portion of the bladder.

Priority: US1987-056401 Applic. Date: 1987-05-29

Inventor: LUNDQUIST INGEMAR H [US]; TARCZY-HORNOCH ZOLTAN [US]; KARDOS THOMAS J [US]


Patent No.: US5014718A  Issued: 14/May/1991

Title: Blood collection and testing method

Applicant/Assignee: SAFETY DIAGNOSTICS, INC

Application No.: 411083   Filing Date: 22/Sep/1989

Abstract:

A relatively painless method of safely collecting and testing blood comprises piercing a patient's skin, bathing the pierced area with a vehicle liquid and collecting a sample of the vehicle liquid and any blood on a test disk in the apparatus. A novel disposable apparatus for practicing the method also is described.

Priority: US1988-147138 Applic. Date: 1988-01-22

Inventor: MITCHEN JOEL R [US]


Patent No.: US5019269A  Issued: 28/May/1991

Title: Polymers derived from crosslinked polystyrenes and dextrans, their methods of preparation and their applications for the analysis and purification of molecules of biological origin

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Application No.: 497560   Filing Date: 21/Mar/1990

Abstract:

Priority: FR19870011813 Applic. Date: 1987-08-21

Inventor: LETOURNEUR DIDIER [FR]; DOUZON COLETTE [FR]; MIGONNEY VERONIQUE [FR]; MULLER DANIEL A [FR]; JOZEFOWICZ MARCEL [FR]


Patent No.: US5024998A  Issued: 18/Jun/1991

Title: Pharmaceutical formulations for parenteral use

Applicant/Assignee: UNIVERSITY OF FLORIDA

Application No.: 448655   Filing Date: 11/Dec/1989

Abstract:

Aqueous parenteral solutions of drugs which are insoluble or only sparingly soluble in water and/or which are unstable in water, combined with cyclodextrin selected from the group consisting of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of beta - and gamma -cyclodextrin, provide a means for alleviating problems associated with drug precipitation at the injection site and/or in the lungs or other organs following parenteral administration.

Priority: US1987-139755 Applic. Date: 1987-12-30; US1988-174945 Applic. Date: 1988-03-29

Inventor: BODOR NICHOLAS S [US]


Patent No.: US5030215A  Issued: 09/Jul/1991

Title: Preparation of fibrinogen/factor XIII precipitate

Applicant/Assignee: CRYOLIFE, INC

Application No.: 460640   Filing Date: 03/Jan/1990

Abstract:

The present invention relates to a system for use in the preparation of autologous or single-donor fibrin sealant. The invention further relates to a method of preparing fibrin sealant.

Priority:

Inventor: MORSE BRENDA S [US]; TURNER A DENISE [US]; CARPENTER JOHN F [US]


Patent No.: US5037419A  Issued: 06/Aug/1991

Title: Blood bag system containing vitamin E

Applicant/Assignee: EASTMAN KODAK COMPANY

Application No.: 410205   Filing Date: 21/Sep/1989

Abstract:

Priority:

Inventor: VALENTINE DAVID L [US]; PAPAS ANDREAS M [US]; OSTERMEYER EDWARD T [US]; HUFFAKER JAMES E [US]; TAGGART EILEEN M [US]


Patent No.: US5053025A  Issued: 01/Oct/1991

Title: Method and apparatus for extracting fluid

Applicant/Assignee: CRYO-CELL INTERNATIONAL, INC

Application No.: 577269   Filing Date: 04/Sep/1990

Abstract:

An apparatus for extracting blood fluids from a placenta and umbilical cord comprises a frame assembly, a rotary carriage mounted to the frame assembly for rotation about a vertical axis, a drive operatively connected to the carriage for rotating the carriage about the axis, and a support for holding the placenta and the umbilical cord. A connector pivotably connects the support to the carriage to enable a pivoting of the support about a rotating horizontal axis during rotating of the carriage by the drive, while a collector is attached to the support for enabling a collection of fluid flowing from the placenta and the umbilical cord during operation of the drive. A fluid delivery system is provided for automatically supplying an anticoagulant to extracted blood fluid.

Priority:

Inventor: KNIPPSCHEER HERMANN [US]


Patent No.: US5055198A  Issued: 08/Oct/1991

Title: AUTOLOGOUS BLOOD RECOVERY MEMBRANE SYSTEM AND METHOD

Applicant/Assignee:

Application No.: 525536   Filing Date: 18/May/1990

Abstract:

An apparatus for recycling autologous blood from a patient for reinfusion back to the patient comprising suction means, admixing means for admixing aspirated blood with a washing fluid, filtering means for filtering the admixture through an emboli filter and a membrane filter, monitoring means for measuring the amount of cellular component volume in the filtered blood, filtration means for removing excess fluid and particulates from the blood, and reinfusion means is disclosed. Embodiments for use during surgery for on-line purification and reinfusion on a real time basis are disclosed along with embodiments for use post-surgically when the wound site is closed and drainage tubing has been implanted at the wound site to draw off blood post-surgically. Methods for performing the autotransfusion process are also disclosed.

Priority: US1990-491183 Applic. Date: 1990-03-07

Inventor: SHETTIGAR U RAMAKRISHNA [US]


Patent No.: US5091304A  Issued: 25/Feb/1992

Title: Whole blood activated partial thromboplastin time test and associated apparatus

Applicant/Assignee: INTERNATIONAL TECHNIDYNE CORPORATION

Application No.: 396043   Filing Date: 21/Aug/1989

Abstract:

An activated partial thromboplastin time (APTT) test is described which does not require blood which has been anticoagulated with citrate. The test enables the citrate anticoagulant step to be combined with the contact activation step and hence enables one to employ fresh non-anticoagulated blood specimens to directly perform the APTT Test.

Priority:

Inventor: LA DUCA FRANK M [US]; MARCELINO EDUARDO I [US]


Patent No.: US5103651A  Issued: 14/Apr/1992

Title: PLASMA STORAGE FREEZER AND THERMAL TRANSPORT DEVICE

Applicant/Assignee: INSTACOOL INC OF NORTH AMERICA

Application No.: 575836   Filing Date: 31/Aug/1990

Abstract:

Priority:

Inventor: COELHO PHILIP H [US]; WOLF TERRY [US]


Patent No.: US5114672A  Issued: 19/May/1992

Title: Method for preserving blood fluid

Applicant/Assignee: CRYO-CELL INTERNATIONAL, INC

Application No.: 573646   Filing Date: 27/Aug/1990

Abstract:

In a method for preserving umbilical cord blood, a severed umbilical cord is provided which has at least one tubular blood vessel closed at opposite ends to maintain fluid in the vessel. An anticoagulant is added to blood fluids in the vessel, and the blood fluid is moved in the vessel to distribute the anticoagulant throughout the blood. An associated apparatus comprises a container, a support within the container for supporting an umbilical cord, an injector or other fluid adding device engageable with the umbilical cord in the container for introducing an anticoagulant into at least one tubular vessel in the umbilical cord, and a fluid moving device at least partially inside the container for moving blood fluid contained in the tubular vessel.

Priority:

Inventor: KNIPPSCHEER HERMANN [US]; RICHARD DANIEL D [US]


Patent No.: US5116307A  Issued: 26/May/1992

Title: Method and system for treatment of AIDS

Applicant/Assignee:

Application No.: 549961   Filing Date: 09/Jul/1990

Abstract:

The method and system for the extracorporeal or extravascular treatment of blood employs diethyl ether for killing HIV cells in the blood. In practicing the method with the system, blood is withdrawn from one arm of a patient through a tubing to a container, e.g. a syringe barrel, where the blood is exposed to vaporized diethyl ether, which has been vaporized by heating, thereby to enable the diethyl ether to strip the viral envelope away from HIV cells attached to macrophages and dissolve the lipid layers thereof thereby to kill the HIV cells. The blood with ether is then passed through a manifold where a vacuum is drawn on the blood to remove most of the ether from the blood. The treated blood is then returned by a tubing and needle to the other arm of the patient. A blood thinner or anticoagulant preferably is given first to the patient orally or intravenously. Also preferably an electrical pulse is supplied to the arm of the patient upstream of the point where blood is removed for the purpose of inhibiting the clumping of the infected white blood cells to non-infected white blood cells thereby to force the HIV cells, or macrophages containing HIV cells, into the blood stream so that they are more vulnerable to being destroyed by the ether. Further, if desired, new blood can be introduced into the patient's other arm with the returned treated blood to provide "make up" blood cells for blood cells that may have been destroyed by the ether.

Priority:

Inventor: COLLINS HARVEY T [US]


Patent No.: US5120537A  Issued: 09/Jun/1992

Title: FACTOR XA BASED ANTICOAGULANT COMPOSITIONS

Applicant/Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATION

Application No.: 367544   Filing Date: 14/Jun/1989

Abstract:

An anticoagulant composition containing an effective amount of factor Xa having the active serine site inactivated that functions rapidly and effectively in vivo to suppress coagulation. In a preferred embodiment, Factor Xa, a serine esterase that forms a complex with Factor Va, Ca++, and phospholipid to catalyze prothrombin activation, is first inactivated with an active site inhibitor, such as dansyl-glu- gly-arg-chloromethyl ketone, to form inactivated factor Xa. In another embodiment, Factor Xa is expressed from a gene sequence wherein the portion encoding the active serine region is modified. The inactivated protein retains the ability to bind to endogenous factor Va in vivo, and has a half-life of approximately ten hours. Administration of inactive factor Xa to the blood of a patient results in the formation of inactive factor Xa-Va complexes in vivo, thereby inhibiting coagulation.

Priority:

Inventor: ESMON CHARLES T [US]; TAYLOR JR FLETCHER B [US]


Patent No.: US5128270A  Issued: 07/Jul/1992

Title: ASSAY OF MONOKINES

Applicant/Assignee: IRE-MEDGENIX S.A

Application No.: 299803   Filing Date: 06/Jan/1989

Abstract:

PCT No. PCT/EP88/00430 Sec. 371 Date Jan. 6, 1989 Sec. 102(e) Date Jan. 6, 1989 PCT Filed May 18, 1988 PCT Pub. No. WO88/09508 PCT Pub. Date Dec. 1, 1988.The invention relates to assays of a monokine in a biological fluid, in particular in a blood sample, in particular of TNF or of IL-1. According to the present invention, the monokine in the serum or plasma obtained from whole blood stimulated with a mitogenic agent is assayed prior to any separation between the plasma (or serum) and the blood cells. According to another subject of the invention, the monokine is assayed in the case of an immunometric assay employing an oligoclonal system, consisting of several different monoclonal antibodies adsorbed on a solid phase and a non-adsorbed labeled antibody. The invention also relates to immunoassay kits.

Priority: FR19870006988 Applic. Date: 1987-05-19

Inventor: DELACROIX DOMINIQUE [BE]; DE GROOTE DONAT [BE]; FRANCHIMONT PAUL [BE]; GYSEN PHILIPPE [BE]; REUTER AIMEE [BE]; DEHART ISABELLE [BE]


Patent No.: US5135667A  Issued: 04/Aug/1992

Title: METHOD AND APPARATUS FOR ADMINISTRATION OF ANTICOAGULANT TO RED CELL SUSPENSION OUTPUT OF A BLOOD SEPARATOR

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 538306   Filing Date: 14/Jun/1990

Abstract:

Method and apparatus for machine separation of blood and blood components that utilizes improved administeration of anticoagulant to the red cell suspension output. Anticoagulant is added to incoming whole blood in an amount sufficient to prevent clotting of the whole blood in the flow path upstream of the blood component separator, but in an amount insufficient to prevent clotting of the red cell suspension created by the separator. Anticoagulant is added to the red cell suspension downstream of the separator in order to prevent clotting. By adding an additional aliquot of anticoagulant to the red cell suspension, the amount of anticoagulant added to whole blood before separation can be reduced or eliminated, resulting in an increase in platelet yield during the blood component separation step.

Priority:

Inventor: SCHOENDORFER DONALD W [US]


Patent No.: US5135955A  Issued: 04/Aug/1992

Title: Propanamine derivatives

Applicant/Assignee: ELI LILLY AND COMPANY

Application No.: 313571   Filing Date: 22/Feb/1989

Abstract:

Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions containing them.

Priority: US1988-185675 Applic. Date: 1988-04-25

Inventor: CAMPBELL JACK B [US]; SMITH GERALD F [US]; TURNER WILLIAM W [US]


Patent No.: US5141490A  Issued: 25/Aug/1992

Title: SINGLE-NEEDLE TYPE PLASMA SEPARATION APPARATUS AND PLASMA COLLECTION APPARATUS

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 515730   Filing Date: 26/Apr/1990

Abstract:

Priority: JP19890163339 Applic. Date: 1989-06-25

Inventor: FUJII TATSUYA [JP]; KEINO HIROYUKI [JP]


Patent No.: US5141501A  Issued: 25/Aug/1992

Title: Suction metering and mixing device

Applicant/Assignee: VERNAY LABORATORIES, INC

Application No.: 526086   Filing Date: 21/May/1990

Abstract:

A suction metering and mixing device is disclosed for collecting body fluids such as blood and simultaneously mixing an anticoagulant therewith. The device includes a suction passage having an inlet end and an opposite end for connection to a vacuum supply. A chamber is provided for controlling the flow of anticoagulant and includes an inlet port defining a passage for entry of anticoagulant into the chamber and a diaphragm dividing the chamber into first and second portions wherein the diaphragm is in contact with the inlet port to prevent flow of anticoagulant into the first chamber portion. A fluid connection is provided between the suction passage and the second chamber portion whereby a vacuum may be supplied to the second chamber portion from the suction passage and the diaphragm is drawn away from the inlet port to allow anticoagulant to flow into the first chamber portion. The anticoagulant then flows through a supply tube to a position adjacent to the inlet to the suction passage where it is mixed with blood entering the suction passage.

Priority:

Inventor: ATKINSON GORDON E [US]; BAILEY JAMES C [US]


Patent No.: US5156611A  Issued: 20/Oct/1992

Title: BLOOD MICROSAMPLING SITE PREPARATION METHOD

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 474877   Filing Date: 05/Feb/1990

Abstract:

Priority:

Inventor: HAYNES JOHN L [US]; TITUS GEORGE R [US]


Patent No.: US5160333A  Issued: 03/Nov/1992

Title: METHOD FOR MIXING BLOOD WITH ANTICOAGULANT

Applicant/Assignee: SOLCO HOSPITAL PRODUCTS GROUP, INC

Application No.: 649831   Filing Date: 01/Feb/1991

Abstract:

Priority:

Inventor: WELLS JOHN R [US]


Patent No.: US5171456A  Issued: 15/Dec/1992

Title: AUTOMATED BLOOD COMPONENT SEPARATION PROCEDURE AND APPARATUS PROMOTING DIFFERENT FUNCTIONAL CHARACTERISTICS IN MULTIPLE BLOOD COMPONENTS

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 538301   Filing Date: 14/Jun/1990

Abstract:

Method and apparatus are provided for machine separation of blood into blood components, wherein a preselected fluid such as anticoagulant is added to at least two different locations through the fluid flow path of the set, in order to promote the different functional characteristics in different blood components. The method results in reduced incidence of citrate reaction in the blood donor and increased platelet yield in platelet rich plasma collected during the procedure.

Priority:

Inventor: HWANG YEAN YOW [US]; RITCHEY BRIAN [US]; SCHOENDORFER DONALD W [US]


Patent No.: US5174872A  Issued: 29/Dec/1992

Title: METAL-FREE BUFFER FOR ION SELECTIVE ELECTRODE-BASED ASSAYS

Applicant/Assignee: TECHNICON INSTRUMENTS CORPORATION

Application No.: 535631   Filing Date: 08/Jun/1990

Abstract:

Priority:

Inventor: SCOTT WILLIAM J [US]


Patent No.: US5179081A  Issued: 12/Jan/1993

Title: Method of treatment using an anticoagulant polypeptide

Applicant/Assignee: KOWA CO., LTD

Application No.: 693063   Filing Date: 01/May/1991

Abstract:

A polypeptide having an amino acid sequence as shown in FIG. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines and preventin in vivo blood coagulation.

Priority: JP19880182633 Applic. Date: 1988-07-21; US1989-379266 Applic. Date: 1989-07-13

Inventor: IWASAKI AKIO [JP]; SUDA MAKOTO [JP]; SAINO YUSHI [JP]


Patent No.: US5185001A  Issued: 09/Feb/1993

Title: Method of preparing autologous plasma fibrin and application apparatus therefor

Applicant/Assignee: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

Application No.: 467143   Filing Date: 18/Jan/1990

Abstract:

A method of preparing autologous plasma fibrin perioperatively to induce local hemostasis is disclosed. The autologous plasma fibrin is thereafter simultaneously expelled onto a treatment site along with a physiologically acceptable thrombin solution to effect hemostasis at the site. An apparatus for simultaneously expelling the contents of vessels which separately contain the autologous plasma fibrin and thrombin solutions, respectively, is also disclosed. A kit for obtaining a sample of blood, extracting plasma fibrin therefrom, as well as all necessary syringes, needles, reagents, and the inventive apparatus is also disclosed.

Priority:

Inventor: GALANAKIS DENNIS K [US]


Patent No.: US5188588A  Issued: 23/Feb/1993

Title: Single needle continuous hemapheresis apparatus and methods

Applicant/Assignee: BAXTER INTERNATONAL INC

Application No.: 455794   Filing Date: 20/Dec/1989

Abstract:

Blood separation is accomplished by alternately extracting blood from and reinfusing blood into a donor by way of a single needle while simultaneously and continuously separating the extracted blood into constituents. A harness set applicable to a hemapheresis instrument includes a dual-compartment reservoir. A first compartment stores blood during extraction for supply to the separator during reinfusion. The second compartment stores packed cells during collection for return to the donor during reinfusion. The collection and reinfusion cycles are alternated rapidly to preclude clotting in the un-anticoagulated portion of the harness tubing between the venepuncture needle and the Y-connection with the anticoagulant line.

Priority: US1987-125102 Applic. Date: 1987-11-25; US1989-348166 Applic. Date: 1989-05-02

Inventor: SCHOENDORFER DONALD W [US]; PRINCE PAUL R [US]


Patent No.: US5192745A  Issued: 09/Mar/1993

Title: Cyclic anticoagulant peptides

Applicant/Assignee: MERRELL DOW PHARMACEUTICALS INC

Application No.: 764989   Filing Date: 23/Sep/1991

Abstract:

This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.

Priority: US1987-053204 Applic. Date: 1987-05-21; US1989-405106 Applic. Date: 1989-09-08

Inventor: KRSTENANSKY JOHN L [US]; MAO SIMON J T [US]


Patent No.: US5192747A  Issued: 09/Mar/1993

Title: Anticoagulant peptides

Applicant/Assignee: MERRELL DOW PHARMACEUTICALS INC

Application No.: 803666   Filing Date: 03/Dec/1991

Abstract:

The invention relates to peptide derivatives which are useful anticoagulant agents.

Priority: US1989-416336 Applic. Date: 1989-10-03

Inventor: KRSTENANSKY JOHN L [US]


Patent No.: US5194589A  Issued: 16/Mar/1993

Title: Leech protein having anticoagulant and antimetastatic properties

Applicant/Assignee: PENNSYLVANIA HOSPITAL

Application No.: 657356   Filing Date: 15/Feb/1991

Abstract:

The present invention comprises a biochemically pure protein, termed antistasin, which exhibits both antimetastatic and anticoagulant properties. Methods of producing the protein and methods of using the protein to inhibit or reduce metastasis and/or coagulation of blood are disclosed. The complete amino acid sequences of antistasin and some variants have been determined from purified protein and cloned cDNAs.

Priority: US1987-088432 Applic. Date: 1987-08-26; US1988-144453 Applic. Date: 1988-01-15; US1986-908581 Applic. Date: 1986-09-18

Inventor: BOTT JOHN A [US]


Patent No.: US5200090A  Issued: 06/Apr/1993

Title: Multiple fluid source isolation, metering and alarm system and method

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 769335   Filing Date: 01/Oct/1991

Abstract:

A system is provided for weighing and monitoring flow from multiple fluid sources into a flow system wherein incoming fluid is received in a weighing bag attached to a control system for monitoring the amount of fluid passed through the weighing bag and for preventing admission of air into the flow system. An alarm attached to the weighing bag warns when fluid in the weighing bag is approaching empty, so that the fluid in the weighing bag can be replenished from the fluid source before the weighing bag runs dry. If fluid in the weighing bag is not replenished, the system automatically shuts down. The fluid pump can be absolutely calibrated using the controlled admission of known amounts of fluid into the weighing bag so that the amount of fluid introduced into the flow system through the weighing bag can be calculated automatically.

Priority: US1990-502395 Applic. Date: 1990-03-30

Inventor: FORD MICHAEL G [US]; PRINCE PAUL R [US]


Patent No.: US5204323A  Issued: 20/Apr/1993

Title: Heparin and hirudin antidotal compositions and methods

Applicant/Assignee: CIBA-GEIGY CORPORATION

Application No.: 763477   Filing Date: 20/Sep/1991

Abstract:

The invention provides an antidote to blood anticoagulants comprising Factor VIII or fragments of Factor VIII which retain its activity or a substance which increases its concentration in blood.

Priority: GB19880023480 Applic. Date: 1988-10-06; US1989-416882 Applic. Date: 1989-10-04

Inventor: FINDLAY VALERIE S [US]; KERRY ROGER [US]; PAY GRAHAM F [US]; WALLIS ROBERT B [US]; BUTLER KEITH D [GB]


Patent No.: US5213765A  Issued: 25/May/1993

Title: BLOOD COLLECTION TUBE

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 691855   Filing Date: 26/Apr/1991

Abstract:

Priority: JP19900110401 Applic. Date: 1990-04-27

Inventor: KASAI MASAAKI [JP]; YAMAZAKI SAKAE [JP]


Patent No.: US5213813A  Issued: 25/May/1993

Title: Pyridoxal-5'-phosphate as an in vitro blood platelet stabilizer

Applicant/Assignee: THE UNIVERSITY OF VERMONT

Application No.: 532909   Filing Date: 04/Jun/1990

Abstract:

The use of pyridoxal-5'-phosphate as an in vitro anticoagulant agent which retains the platelet activity of stored whole blood or stored plasma for more than about six hours is disclosed.

Priority: US1987-055637 Applic. Date: 1987-05-29

Inventor: KORNECKI ELIZABETH H [US]; EHRLICH VIGAL H [US]


Patent No.: US5221616A  Issued: 22/Jun/1993

Title: Prevention of spontaneous complement activation in mammalian biological fluids

Applicant/Assignee: QUIDEL CORPORATION

Application No.: 219922   Filing Date: 15/Jul/1988

Abstract:

Selected polyhydroxyl compounds, comprising monosaccharides, disaccharides and oligosaccharides, as well as certain of their derivatives, are effective in preventing the spontaneous activation of complement in vitro. The effect is enhanced in the presence of an anticoagulant together with a divalent cation chelator. Addition of these compounds makes it possible to store clinical samples at conventional temperatures from -20 DEG to +22 DEG C. for extended periods prior to performing complement protein assays. Effective compounds are selected through a screening protocol which comprises the use of immunoassays for complement fragments together with an algorithm for computing effectiveness. Polyhydroxyl compounds extend similar protection from activation to coagulation proteins.

Priority:

Inventor: KOLB WILLIAM P [US]; KOLB LINDA M [US]; TAMERIUS JOHN D [US]


Patent No.: US5227138A  Issued: 13/Jul/1993

Title: Blood transport apparatus

Applicant/Assignee: VIRGINIA MASON CLINIC

Application No.: 942520   Filing Date: 09/Sep/1992

Abstract:

An apparatus for transporting blood samples within a capillary tube using a rigid plate member to protect the capillary tube during transport. A magnet is magnetically coupled with and thereby moves a ferrous metal flea within the capillary tube to promote mixing of the blood sample and an anticoagulant chemical coating on the inside of the capillary tube. The magnet is slid along the length of a recessed guide track or guide members to assure that the magnet does not come in contact with the capillary tube with sufficient force to break the capillary tube. The magnet has a central archway through which the capillary tube extends to increase the magnetic coupling between the magnet and the flea and yet prevent contact with the capillary tube. The capillary tube is held within an alignment groove in the rigid plate member. In one embodiment, a holder holds the capillary tube against the rigid plate. A recess is provided to receive one end of the capillary tube and a slot is provided to receive the other end of the capillary tube to help retain the tube. An opening through the rigid plate member near the slot allows the easy extraction of the capillary tube from the apparatus.

Priority:

Inventor: BOYD KAREN A [US]; FAYETTE DANA [US]


Patent No.: US5232437A  Issued: 03/Aug/1993

Title: Mobile, self-contained blood collection system and method

Applicant/Assignee: BAXTER INTERNATIONAL INC

Application No.: 496739   Filing Date: 21/Mar/1990

Abstract:

Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood from a donor

forcing the collected blood unit through a plasma separator

accumulating the plasma in a container

and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.

Priority: US1989-296850 Applic. Date: 1989-01-12; US1986-919346 Applic. Date: 1986-10-15

Inventor: LYSAGHT MICHAEL J [US]; BOGGS DANIEL R [US]; RITGER PHILIP L [US]; STROMBERG ROBERT R [US]; FRIEDMAN LEONARD I [US]


Patent No.: US5232912A  Issued: 03/Aug/1993

Title: Anticoagulant peptides

Applicant/Assignee: MERRELL DOW PHARMACEUTICALS INC

Application No.: 970596   Filing Date: 30/Oct/1992

Abstract:

This invention relates to peptide derivatives which are useful anticoagulant agents.

Priority: US1988-281121 Applic. Date: 1988-12-07; US1991-645539 Applic. Date: 1991-01-24

Inventor: KRSTENANSKY JOHN L [US]


Patent No.: US5234403A  Issued: 10/Aug/1993

Title: Blood collecting apparatus

Applicant/Assignee: SUMITOMO BAKELITE CO., LTD KURARAY CO., LTD

Application No.: 705211   Filing Date: 24/May/1991

Abstract:

A blood collecting apparatus for collecting and reserving blood lost from the patient during or after operation, wherein thrombus contained in the collected blood is removed, and it is possible to prevent the new generation of the thrombus. The apparatus may readily be used safely. The apparatus includes a blood collecting container, a suction pipe having a branched pipe provided with a sterilizing filter, a collecting pipe provided with a port for supplying a blood anti-coagulant and a blood filter, and a discharge pipe having a blood filter. These pipes are connected to an upper part of the container. A suction unit is connected to an end portion of the suction pipe. A catheter or the like is connected to the end of the collecting pipe. The section unit is operated to suck and collect the blood from the incision during or after the operation.

Priority: JP19900080094U Applic. Date: 1990-07-26; JP19900134076 Applic. Date: 1990-05-25

Inventor: YODA TAKUMI [JP]; FUJI TAKESHI [JP]; TANAKA SOICHI [JP]; NISHIJIMA MAMORU [JP]; IZUMI YASUNOBU [JP]; IDA MITSUHIRO [JP]


Patent No.: US5236898A  Issued: 17/Aug/1993

Title: Cyclic anticoagulant peptides

Applicant/Assignee: MERRELL DOW PHARMACEUTICALS INC

Application No.: 763885   Filing Date: 20/Sep/1991

Abstract:

This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.

Priority: US1987-053169 Applic. Date: 1987-05-21; US1989-405108 Applic. Date: 1989-09-08

Inventor: KRSTENANSKY JOHN L [US]; MAO SIMON J T [US]


Patent No.: US5247434A  Issued: 21/Sep/1993

Title: Method and apparatus for kidney dialysis

Applicant/Assignee: ALTHIN MEDICAL, INC

Application No.: 688174   Filing Date: 19/Apr/1991

Abstract:

A number of improvements relating to methods and apparatuses for kidney dialysis are disclosed. These include checking of dialysate bypass status using flow measurement

using a flow sensor to confirm the absence of ultrafiltration during bypass

automatic testing of ultrafiltration function by removal of a discrete volume from a portion of the dialysate flow path coupled with a pressure test of that part of the flow path

using a touch screen user interface

bar graph profile programming of ultrafiltration, sodium, and bicarbonate parameters

using a RAM card to upload treatment instructions to, and to download treatment data from, the machine

automatic setting of proportioning mode (acetate or bicarbonate) based on connections of concentrate lines

predicting dialysate conductivity values based on brand and formulation of concentrates

minimizing no-flow dead time between dialysate pulses

initiating operation in a timed mode from a machine power-off condition

preserving machine mode during machine power-fail condition

calibration scheduling and reminding

automatic level adjusting

and blood leak flow rate detecting.

Priority: EP19930850098 Applic. Date: 1993-05-05

Inventor: PETERSON BRUCE A [US]; HOGARD MICHAEL E [US]; JOHNSON HARLEY D [US]; KELLY THOMAS D [US]; LONG JEAN M [US]; PRESTON JR WILLIAM G [US]


Patent No.: US5250004A  Issued: 05/Oct/1993

Title: Device for withdrawing blood from slaughter animals

Applicant/Assignee: ANITEC-JOHN SJOBERG AB

Application No.: 776406   Filing Date: 22/Nov/1991

Abstract:

PCT No. PCT/SE89/00284 Sec. 371 Date Nov. 22, 1991 Sec. 102(e) Date Nov. 22, 1991 PCT Filed May 22, 1989 PCT Pub. No. WO90/14013 PCT Pub. Date Nov. 29, 1990.A device for withdrawing blood from slaughter animals transported on a conveyor serially past a sticking station has a debleeding carousel (1) disposed at the sticking station and consisting of a body (2), a lower frame member (3) and an upper member frame (4), which frame members are synchronously rotatable on a vertical shaft (5) of the body, a number of collecting vessels (6) mounted on the lower frame member around the vertical shaft, a number of hollow knives (7) corresponding to the number of collecting vessels and suspendible around the vertical shaft each in a holder (9) on the upper frame member, and a hose (8)

extending between each hollow knife and the associated collecting vessel for conducting blood from the hollow knife to the collecting vessel. The debleeding carousel is rotatable in such steps that the holders are displaced between a number of stopping positions around the vertical shaft, the distance between the stopping positions being equal to the distance between the holders. A sensor is fixedly mounted on the body opposite one of the stopping positions and adapted to sense the displacement of a hollow knife in a holder located in this stopping position, in order upon such displacement to initiate rotation of the carousel one step.

Priority: WO1989SE00284 Applic. Date: 1989-05-22

Inventor: SJOEBERG JOHN A [SE]


Patent No.: US5250303A  Issued: 05/Oct/1993

Title: Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG

Applicant/Assignee: THE AMERICAN NATIONAL RED CROSS

Application No.: 594152   Filing Date: 09/Oct/1990

Abstract:

This invention provides an improved method for prolonging the shelf life of transfusible red blood cells by decreasing the effective osmolality of the suspending solution and increasing the intracellular pH of the cells prior to storage thereof. This invention also provides methods whereby the intracellular pH may be increased. These methods include collecting the cells in an anticoagulant at pH 7.0 or higher and/or washing, diluting or resuspending the cells prior to storage thereof in a biologically compatible buffered solution that contains at least one non-penetrating or substantially non-penetrating anion or non-electrolyte and is substantially free of chloride ions.

Priority: US1989-417761 Applic. Date: 1989-10-06

Inventor: MERYMAN HAROLD T [US]; HORNBLOWER MARNE [US]; SYRING RALPH [US]


Patent No.: US5257984A  Issued: 02/Nov/1993

Title: Blood collector

Applicant/Assignee: NORFOLK SCIENTIFIC, INC

Application No.: 771054   Filing Date: 02/Oct/1991

Abstract:

Apparatus for transferring a blood specimen from a droplet source to a collection tube via a capillary tube. A glass anticoagulant-coated or an untreated capillary tube and a collection tube with a stopper having an X-slit membrane for admission of the capillary tube into the collection tube with the stopper on. A separating gel may be located in the collection tube to provide plasma and serum separation when the collection tube is centrifuged.

Priority:

Inventor: KELLEY THOMAS F [US]


Patent No.: US5258023A  Issued: 02/Nov/1993

Title: Prosthetic heart valve

Applicant/Assignee: REGER MEDICAL DEVELOPMENT, INC

Application No.: 834416   Filing Date: 12/Feb/1992

Abstract:

A novel long lasting prosthetic heart valve compatible with implantation in a human natural heart valve annulus. The prosthetic heart valve comprises a trileaflet heart valve apparatus which in form, dimension, and function resembles a human trileaflet heart valve, but which is formed of synthetic resinous material. A seamless supporting frame capable of annular deformation and limited perimetric expansion during each heartbeat is totally enveloped in an essentially biologically inert cylindrical cover to form a cusp supporting stent for the valve leaflet apparatus. The free top and bottom edges of the cylindrical cover are disposed on the exterior of the stent and everted outward to provide at least one sewing ring. Valve embodiments comprise aortic and mitral implantable valves. For the aortic implant, the outwardly everting free sewing ring forming edges are separated by circumferentially disposed compressible and expandable material which provides a pliable, compliant interface between the valve and the natural valve annulus at the implanting site. Valve sewing ring covers can be selectively impregnated with antibiotic medicants to substantially eliminate early post implant infection. Use of non-thrombogenic biochemically inert materials in a valve apparatus which mimics operation of a natural heart valve essentially eliminates the need for long term administration of anticoagulants.

Priority:

Inventor: REGER VINCENT A [US]


Patent No.: US5261876A  Issued: 16/Nov/1993

Title: Enhanced peritoneal membrane plasmapheresis

Applicant/Assignee: MONCRIEF-POPOVICH RESEARCH INSTITUTE, INC

Application No.: 899676   Filing Date: 12/Jun/1992

Abstract:

The method of treatment called peritoneal membrane plasmapheresis for removal of plasma proteins is enhanced by specification of a sequence of two or three solutions for instilling into and draining from the peritoneal cavity. Solution 1 contains a vosodilator, solution 3 contains no vasoactive drug, and solution 2 contains a vasoconstrictor. Choice of the sequence of solutions to be instilled and drained according to the claimed methods results in sustained opening of peritoneal membrane pores and substantially elevated rates of plasma protein removal, avoiding the problem of declining rates due to local tissue compensatory mechanisms which are observed when only solution 1 is used. Resulting protein removal rates in an anticoagulated patient compare favorably with those attainable with extracorporeal phasmapheresis. An analogous process may be carried out to increase the pore size of any biological membrane accessible to the solutions.

Priority:

Inventor: POPOVICH ROBERT P [US]; MONCRIEF JACK W [US]; HE ZHENGZHI [US]


Patent No.: US5262325A  Issued: 16/Nov/1993

Title: Method for the enzymatic neutralization of heparin

Applicant/Assignee: IBEX TECHNOLOGIES, INC

Application No.: 680330   Filing Date: 04/Apr/1991

Abstract:

A heparinase formulation derived from Flavobacterium heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from Flavobacterium heparinum, is free of a component that inhibits coagulation. It is stable under normal manufacturing, shipping and clinical storage conditions for at least one year. The heparinase in useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this preparation are that it achieves neutralization faster and more completely than previously available compositions and is stable for long periods of time.

Priority:

Inventor: ZIMMERMANN JOSEPH J [US]; LEWIS N TRACEY [CA]; HEFT ROBERT A [CA]


Patent No.: US5268366A  Issued: 07/Dec/1993

Title: Polysaccharide composition or polysaccharide having heparinoid activity, process for producing the same, and anticoagulant containing the same as active ingredient

Applicant/Assignee: NISSHINBO INDUSTRIES, INC

Application No.: 757786   Filing Date: 11/Sep/1991

Abstract:

Priority: JP19900241004 Applic. Date: 1990-09-11

Inventor: MAEDA MASAAKIRA [JP]; UEHARA TSUTOMU [JP]; TAKESHITA MASAO [JP]


Patent No.: US5289255A  Issued: 22/Feb/1994

Title: Cuvette for use in making a measurement of a blood parameter and assembly utilizing the same

Applicant/Assignee: MINNESOTA MINING AND MANUFACTURING CO

Application No.: 676956   Filing Date: 28/Mar/1991

Abstract:

A cuvette comprising a housing having a passage therethrough and being adapted to receive blood. The housing has a wall with an outer face. An optical window leads from the outer face to the passage and the optical window is transmissive to an optical signal so that a parameter of blood in the passage can be measured. A magnet is carried by the wall and spaced from the optical window for use in providing information about the cuvette. The cuvette is releasably attachable to an optical head. The optical head includes a plurality of Hall effect transducers which respond to the position of the magnet on the housing so that the position of the magnet can be used to provide information about the cuvette.

Priority:

Inventor: MULLIN PAUL J [US]; HEINEMANN STAN O [US]; GORDON MARK G [US]


Patent No.: US5294401A  Issued: 15/Mar/1994

Title: Membrane type of oxygenator and method for production thereof

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 966573   Filing Date: 26/Oct/1992

Abstract:

PCT No. PCT/JP88/00276 Sec. 371 Date Sep. 15, 1989 Sec. 102(e) Date Sep. 15, 1989 PCT Filed Mar. 17, 1988 PCT Pub. No. WO88/06898 PCT Pub. Date Sep. 22, 1988.A membrane type oxygenator for effecting exchange of gases with a porous gas-exchange membrane possessing minute through pores forming a path for gas, which membrane type oxygenator is characterized by the fact that minute particles are retained in the minute pores of the porous gas-exchange membrane to permit a decrease in the cross-sectional area of the path for gas and as blood anticoagulant is retained in the minute particles or between the minute particles, and it is manufactured assembling a membrane type oxygenator containing a porous gas-exchange membrane possessing minute through pores forming a path for gas, then causing a dispersion of minute particles to flow through the interior of the membrane type oxygenator thereby allowing the minute pores to retain the minute particles and permitting a decrease in the cross-sectional area of the path for gas, removing the dispersion remaining within the membrane type oxygenator, and further causing a liquid containing a blood anticoagulant to flow through the interior of the oxygenator and allowing the liquid to pass through the minute pores of the gas-exchange membrane thereby inducing deposition of the blood anticoagulant on the minute particles.

Priority: JP19870063621 Applic. Date: 1987-03-18; WO1988JP00276 Applic. Date: 1988-03-17; US1989-415321 Applic. Date: 1989-09-15

Inventor: HAGIWARA KAZUHIKO [JP]


Patent No.: US5295953A  Issued: 22/Mar/1994

Title: Method and apparatus for extracorporeal separation of fluorochemicals from whole blood of a patient

Applicant/Assignee: HEMAGEN/PFC BAXTER HEALTH CARE CORPORATION

Application No.: 888987   Filing Date: 26/May/1992

Abstract:

Methods and apparatus for practical extracorporeal separation of fluorochemicals from clinically fluorochemical-containing whole blood of a patient. The methods incorporate centrifugal apheresis devices, preferably with low extracorporeal volumes, that provide a means for continuously removing separated fluorochemical-enriched fractions from the centrifuge during processing and return of whole blood-enriched fractions to the patient.

Priority:

Inventor: RICHARD THOMAS J [US]; SCHOENDORFER DONALD W [US]; KAUFMAN ROBERT J [US]; GOODIN THOMAS H [US]


Patent No.: US5296467A  Issued: 22/Mar/1994

Title: Composition comprising an anticoagulant

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 873601   Filing Date: 21/Apr/1992

Abstract:

Pharmaceutical compositions which consist essentially of a vascular anticoagulant annexine, Ca2+, Zn2+, and a pharmaceutically acceptable carrier are disclosed. Also disclosed are processes for preparing such pharmaceutical compositions. Also disclosed are methods of preventing the coagulation of blood by mixing the blood with a vascular anticoagulant annexine, Ca2+ and Zn2+.

Priority: DE19893923500 Applic. Date: 1989-07-15; US1990-552198 Applic. Date: 1990-07-13

Inventor: REUTELINGSPERGER CHRISTIAAN [NL]


Patent No.: US5313969A  Issued: 24/May/1994

Title: Instant pressure-reducing process and device for a blood-gathering tube

Applicant/Assignee:

Application No.: 987175   Filing Date: 08/Dec/1992

Abstract:

The present invention relates to an instant pressure-reducing process and device for a blood-gathering tube which comprises a blood-gathering tube in a state of normal pressure and a pressure reducing device, wherein the blood-gathering tube in a state of normal pressure comprises a tube body made of plastic or other cheap material and an elastic cork. One end of the tube body is an opening and another end is closed. The central part of elastic cork is thinner in favor of being pierced through by the injection needle head, the elastic cork is tightly nested into the opening of tube body under normal pressure so as to separate inside of the tube body from outside. The pressure-reducing device comprises an injection needle head and a pressure-reducing transformer at least. The needle head is nested into the pressure-reducing transformer.

Priority:

Inventor: HSIEH CH ING-LUNG [TW]


Patent No.: US5318512A  Issued: 07/Jun/1994

Title: Blood separation device

Applicant/Assignee: FRESENIUS AG

Application No.: 939672   Filing Date: 03/Sep/1992

Abstract:

Device for the separation of blood with a cannula with the aid of separation in a centrifuge with a blood pump in an inlet line and a collection storage bag, which can be emptied with the aid of a pressure device into a return line. The flow resistance Ro of the return line is designed so that it has preferably about half of the flow resistance of the remainder of the return system. In a return/recirculation phase, the blood pump is operated at a predetermined recirculation flow rate FR, whereby a predetermined cannula infusion flow rate FN is established as a function thereof.

Priority: DE19914129639 Applic. Date: 1991-09-06

Inventor: NEUMANN HANS-JUERGEN [DE]


Patent No.: US5318782A  Issued: 07/Jun/1994

Title: Method for preparing tissue repair promoting substances

Applicant/Assignee:

Application No.: 23814   Filing Date: 25/Feb/1993

Abstract:

A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first container of a container system comprising at least first and second interconnected containers

centrifuging the container system containing said blood so as to separate the blood in various fractions including a plasma fraction

transferring at least part of the plasma fraction to said second container of the container system

subjecting the plasma fraction in said second container to a low temperature so as to obtain a precipitate comprising tissue repair promoting substances

concentrating said precipitate in said second container so as to obtain a first fraction comprising a major part of the non-precipitated material, and a second fraction comprising at least the major part of the precipitate and a minor part of the non-precipitated material

and separating said second fraction comprising the tissue repair promoting substances from said first fraction within the second container

and optionally heating said second fraction within one of the containers of the container system so as to dissolve the isolated precipitated tissue repair promoting substances. Furthermore, fractions comprising tissue repair promoting substances derived from blood cells may be isolated within the container system, said fractions optionally being combined with the second fraction comprising tissue repair promoting substances derived from blood plasma. At least part of the fractions obtained may be kept for application to a tissue of the human or animal individual from whom the blood was collected.

Priority: DK19860004753 Applic. Date: 1986-10-03; US1988-216712 Applic. Date: 1988-07-05; US1990-465430 Applic. Date: 1990-01-16; US1991-704911 Applic. Date: 1991-05-21

Inventor: WEIS-FOGH ULLA S [DK]


Patent No.: US5320537A  Issued: 14/Jun/1994

Title: Microsurgical training apparatus

Applicant/Assignee: TRIANGLE RESEARCH AND DEVELOPMENT CORPORATION

Application No.: 33562   Filing Date: 16/Mar/1993

Abstract:

The invention relates to a disposable, life-like module for use in training physicians and surgeons in the techniques of both human and veterinary microsurgical anastomosis. The module comprises a housing defining a cavity. A pair of spaced apart connectors are connected to the housing and extend therethrough. Each of the connectors includes a bore defining an internal channel for allowing the movement of a fluid through the housing. Each of the channels includes a first end external of the cavity adapted to be in fluid communication with a reservoir and a second end internal of the cavity. A first layer simulates muscle tissue and spans the cavity. An elongate simulated vascular or neurovascular bundle having proximal ends and distal ends spans the chamber and is connected to the respective second connector ends. A pump pumps a fluid simulated blood through a fluid circuit and an optional controller provides pulsatile flow.

Priority:

Inventor: WATSON NEIL A [US]


Patent No.: US5328453A  Issued: 12/Jul/1994

Title: Method for enhancing transdermal drug delivery of electrical drug applicators

Applicant/Assignee: DRUG DELIVERY SYSTEMS INC

Application No.: 834686   Filing Date: 12/Feb/1992

Abstract:

An electrical transdermal drug applicator provides enhanced drug flow to the bloodstream of the subject by delivering a primary drug into a subject's circulatory system for therapeutic purposes, and delivering from the same or other reservoir a non-therapeutic counteracting agent to the skin of the patient which induces flow enhancement and allows delivery of the primary drug systemically over a longer period of time and in greater quantity than heretofore appeared possible using electric current.

Priority: US1988-287348 Applic. Date: 1988-12-21

Inventor: SIBALIS DAN [US]


Patent No.: US5338677A  Issued: 16/Aug/1994

Title: Heparinase free of an anticoagulant component from flavobacterium Heparinum

Applicant/Assignee: IBEX TECHNOLOGIES, INC

Application No.: 153134   Filing Date: 15/Nov/1993

Abstract:

A heparinase derived from Flavobacterium heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from Flavobacterium heparinum, is free of a component that inhibits coagulation wherein the anticoagulant component does not bind, and the heparinase does bind, to a polysulfated resin having a pH of 7.0 and a conductivity between 3 and 12 mmhos. It is stable under normal manufacturing, shipping and clinical storage conditions for at least one year. The heparinase in useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this enzyme are that it achieves neutralization faster and more completely than previously available enzymes and is stable for long periods of time.

Priority: US1991-680330 Applic. Date: 1991-04-04

Inventor: ZIMMERMANN JOSEPH J [US]; LEWIS N TRACEY [CA]; HEFT ROBERT A [CA]


Patent No.: US5344455A  Issued: 06/Sep/1994

Title: Graft polymer articles having bioactive surfaces

Applicant/Assignee: MEDTRONIC, INC

Application No.: 969692   Filing Date: 30/Oct/1992

Abstract:

Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm)m and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.

Priority:

Inventor: KEOGH JAMES R [US]; HOBOT CHRISTOPHER M [US]; EATON JOHN W [US]; JEVNE ALLAN H [US]; BERGAN MATTHEW A [US]


Patent No.: US5344752A  Issued: 06/Sep/1994

Title: Plasma-based platelet concentrate preparations

Applicant/Assignee: THOMAS JEFFERSON UNIVERSITY

Application No.: 43574   Filing Date: 07/Apr/1993

Abstract:

The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding storage extension additives to a platelet concentrate.

Priority: US1991-784695 Applic. Date: 1991-10-30

Inventor: MURPHY SCOTT [US]


Patent No.: US5348533A  Issued: 20/Sep/1994

Title: Pheresis apparatus

Applicant/Assignee: HAEMOENTICS CORPORATION

Application No.: 936569   Filing Date: 27/Aug/1992

Abstract:

The length of time required to draw, centrifugally separate, harvest blood components and return blood components is reduced by providing a two-arm pheresis system in which blood is drawn from one arm, anticoagulated and pumped into an input reservoir then transferred into a centrifuge bowl for separation, while separated blood components are harvested and returned to the donor from an output reservoir via another arm.

Priority:

Inventor: PAPILLON JEAN [US]; YORK FREDERICK J [US]


Patent No.: US5354324A  Issued: 11/Oct/1994

Title: Laser induced platelet inhibition

Applicant/Assignee: THE GENERAL HOSPITAL CORPORATION

Application No.: 600014   Filing Date: 18/Oct/1990

Abstract:

A method for preventing platelet adhesion to a vascular surface in a mammal, which includes irradiating the vascular surface with a pulse of laser energy having a pulse duration less than the thermal relaxation time of the irradiated vascular surface, wherein lasar energy is delivered to said vascular surface via radiographic contrast material.

Priority:

Inventor: GREGORY KENTON W [US]


Patent No.: US5356373A  Issued: 18/Oct/1994

Title: Method and apparatus for autologous transfusions in premature infants

Applicant/Assignee: MILES INC

Application No.: 792824   Filing Date: 15/Nov/1991

Abstract:

Method and apparatus for collecting and storing umbilical blood in a system that allows for the closed aliquoting of small blood volumes for autologous transfusion in neonates. The method involves locating a venous access site on an umbilical cord of the placenta of a neonate. A vacuum pressure is applied to a blood collection bag to facilitate removal of an amount of blood from the umbilical cord. The blood may then be stored in the collection bag and used for subsequent autologous neonate blood transfusion.

Priority:

Inventor: DRACKER ROBERT A [US]


Patent No.: US5356637A  Issued: 18/Oct/1994

Title: Method for preparing an enzymatic hydrolysate

Applicant/Assignee: TESSENDERLO CHEMIE N.V

Application No.: 927639   Filing Date: 04/Sep/1992

Abstract:

PCT No. PCT/BE91/00001 Sec. 371 Date Sep. 4, 1992 Sec. 102(e) Date Sep. 4, 1992 PCT Filed Sep. 11, 1991 PCT Pub. No. WO91/10369 PCT Pub. Date Jul. 25, 1991.An enzymatic hydrolysate having a high di- and tripeptide content is prepared by subjecting to enzymatic proteolysis a protein mixture preliminarily prepared by means of a thermal treatment. The hydrolysate having a high di- and tripeptide content is extracted by liquid-solid separation, followed by ultrafiltration. The hydrolysate is then subjected to a sterilization and drying operation.

Priority: BE19900000044 Applic. Date: 1990-01-12; WO1991BE00001 Applic. Date: 1991-01-11

Inventor: LOOSEN PIERRE C [BE]; BRESSOLLIER PHILIPPE R [FR]; JULIEN RAYMOND A [FR]; PEJOAN CLAUDE H [FR]; VERNEUIL BERNARD G [FR]


Patent No.: US5358482A  Issued: 25/Oct/1994

Title: Single-needle extracorporeal plasmapheresis circuit

Applicant/Assignee: ROERIG FARMACEUTICI ITALIANA S.R.L

Application No.: 133769   Filing Date: 07/Oct/1993

Abstract:

Single-needle extracorporeal plasmapheresis circuit, has a filter in which plasma is separated from the blood with a membrane subject to transmembrane pressure. Two connections to the filter in the blood circuit include one connection of a line to a single needle. An interposed pump is in that line. The other connection has another line to a blood reservoir. A further line connects the plasma side of the filter membrane to a plasma collection bag. Another pump in the further line is controlled by an automatic control means suitable for maintaining the transmembrane pressure in the filter at a value within an optimum range for the entire duration of the plasmapheresis process.

Priority: IT19900022146 Applic. Date: 1990-11-22; US1991-793767 Applic. Date: 1991-11-18

Inventor: PANZANI IVO [IT]


Patent No.: US5370989A  Issued: 06/Dec/1994

Title: Solution for prolonged organ preservation

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 206197   Filing Date: 03/Mar/1994

Abstract:

The present invention provides an aqueous solution for organ preservation or maintenance, including: a vasodilator in an amount sufficient to maintain vascular homeostasis

D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics

magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics

macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability

potassium ions in a concentration greater than about 110 mM

and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about the physiologic pH value. The invention also provides a method of preserving or maintaining an organ, including contacting the organ with the solution.

Priority: US1992-863197 Applic. Date: 1992-04-03

Inventor: STERN DAVID M [US]; OZ MEHMET C [US]; NOWYGROD ROMAN [US]; KOGA SHIN [US]; PINSKY DAVID J [US]


Patent No.: US5372581A  Issued: 13/Dec/1994

Title: Method and apparatus for placental blood collection

Applicant/Assignee: MINNEAPOLIS CHILDREN'S SERVICES CORPORATION

Application No.: 95269   Filing Date: 21/Jul/1993

Abstract:

The present invention relates to an apparatus and a method for the withdrawal of placental blood from an umbilical cord vein. More specifically, the apparatus has a valve housing and a valve member. A needle is attached to a first port in the valve housing and a blood collection bag is attached to a second port in the valve housing. Additionally, a first syringe is attached to a third port, and a second syringe is attached to a fourth port. When the plunger on the first syringe is withdrawn it causes blood to flow from the umbilical vein through the needle and into the syringe. The valve member is then rotated, thereby sealing the needle from the blood collection bag and the syringes. Subsequently, the plunger in the second syringe, which contains an anticoagulant, is pressed. This causes the anticoagulant to mix with the blood. The blood is then stored in the attached storage bag.

Priority:

Inventor: ANDERSON SANFORD J [US]


Patent No.: US5372709A  Issued: 13/Dec/1994

Title: Fluid flow control apparatus

Applicant/Assignee: BIO-FLO LIMITED

Application No.: 70635   Filing Date: 01/Jun/1993

Abstract:

A fluid control apparatus for use in separation and filtration having a removable sterilizable and disposable element which is engagable with a fixed element in the apparatus. When the two elements are engaged, the flow of fluid around a fluid circuit is controlled to optimize separation. The elements contain various conduits and inlet and outlet ports that function to deliver fluid to and from separation and filtration systems such as life support systems.

Priority: GB19880029311 Applic. Date: 1988-12-13; US1991-689246 Applic. Date: 1991-08-14

Inventor: HOOD ROBERT G [GB]


Patent No.: US5375612A  Issued: 27/Dec/1994

Title: Possibly absorbable blood filter

Applicant/Assignee: B. BRAUN CELSA

Application No.: 40259   Filing Date: 30/Mar/1993

Abstract:

The invention relates to an implantable blood filter comprising a self-expanding external structure made from a zigzagged thread wound on itself in order to exhibit a closed configuration. A central strainer section is connected to the said thread at various points for the retention of possible blood clots. This strainer section may be made from a biologically absorbable material. Applications include the production of medical blood filters, which are self-centering and absorbable.

Priority: FR19920004226 Applic. Date: 1992-04-07

Inventor: COTTENCEAU JEAN-PHILIPPE [FR]; CHEVILLON GERARD [FR]; ROUSSIGNE MAURICE [FR]; NADAL GUY [FR]


Patent No.: US5376376A  Issued: 27/Dec/1994

Title: Resorbable vascular wound dressings

Applicant/Assignee:

Application No.: 46895   Filing Date: 15/Apr/1993

Abstract:

The present invention is related to prostheses, their methods of manufacture and methods for repairing vascular lesions using such prostheses. Natural polymers such as collagen are processed and fabricated to form tubular resorbable vascular wound dressings with unique physico-chemical and mechanical properties for repairing selected vascular segments, and for delivering therapeutic agents at selected sites within vessels and at the anastomoses.

Priority: CA19942199951 Applic. Date: 1994-09-14; US1992-821384 Applic. Date: 1992-01-13; WO1994US10423 Applic. Date: 1994-09-14

Inventor: LI SHU-TUNG [US]


Patent No.: US5378227A  Issued: 03/Jan/1995

Title: Biological/pharmaceutical method and apparatus for collecting and mixing fluids

Applicant/Assignee: COBE LABORATORIES, INC

Application No.: 928040   Filing Date: 11/Aug/1992

Abstract:

A blood circulation apparatus includes a suction wand for receiving blood from a patient, a reservoir for collecting received blood, a conduit connecting the suction wand and the reservoir, an anticoagulant pump and line for introducing anticoagulant into the blood upstream of the reservoir, sensors for detecting liquid volume in the reservoir and for transmitting a corresponding volume signal, and a controller for regulating anticoagulant introduction in accordance with a predetermined program and as a function of the volume signal.

Priority:

Inventor: O'RIORDAN JOHN F [US]; ANTWILER GLEN D [US]


Patent No.: US5385885A  Issued: 31/Jan/1995

Title: Inhibition of smooth muscle cell proliferation by antistasin and tick anticoagulant peptide

Applicant/Assignee:

Application No.: 730487   Filing Date: 16/Jul/1991

Abstract:

The present invention provides methods for inhibiting smooth muscle cell proliferation, particularly smooth muscle cells present in blood vessel walls. A compound capable of inhibiting blood factor Xa is administered to the smooth muscle cells in an amount effective to inhibit proliferation of the cells. The compound capable of inhibiting blood factor Xa is preferably antistasin or tick anticoagulant peptide (TAP). In other aspects the present invention provides methods for treating atherosclerotic lesions and atherosclerosis, and methods of treating narrowing of the lumen of a blood vessel wherein the narrowing is caused at least in part by hyperplasia of smooth muscle cells in the wall of the blood vessel.

Priority: US1990-515859 Applic. Date: 1990-04-27; US1988-144453 Applic. Date: 1988-01-15

Inventor: GASIC GREGORY P [US]; GASIC GABRIEL J [US]; GASIC TATIANA B [US]


Patent No.: US5387187A  Issued: 07/Feb/1995

Title: Red cell apheresis method

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 203884   Filing Date: 01/Mar/1994

Abstract:

The present invention provides an apheresis apparatus and method for separating blood. A phlebotomy needle draws anticoagulated whole blood from a donor into a separation chamber. The separation chamber separates plasma from higher density blood components. The plasma is displaced to a plasma collection bag. The separation process is terminated and the higher density blood components remaining in the separation chamber are diluted with saline solution and are returned to the donor via the phlebotomy needle. Anticoagulated whole blood is drawn again from the donor into the separation chamber. The separation chamber again separates plasma from higher density blood components in the separation chamber. The separation process is then terminated and the donor is disconnected. The higher density blood components remaining in the separation chamber are displaced to a bag for collecting higher density blood components and is rejuvenated with additive solution.

Priority: US1992-984029 Applic. Date: 1992-12-01

Inventor: FELL CLAUDE [CH]; PAPILLON JEAN [FR]


Patent No.: US5399318A  Issued: 21/Mar/1995

Title: Blood sampling apparatus containing an anticoagulant composition

Applicant/Assignee: AMERICAN HOME PRODUCTS CORPORATION

Application No.: 236283   Filing Date: 02/May/1994

Abstract:

Disclosed is a blood sampling apparatus containing an anticoagulant composition which allows for the accurate analysis of blood electrolyte concentrations. The claimed apparatus comprises a receptacle, a blood inlet and the disclosed anticoagulant composition which does not unduly bind sodium, potassium or calcium ions from the sampled blood.

Priority: US1993-096123 Applic. Date: 1993-07-22; US1993-009627 Applic. Date: 1993-01-27

Inventor: MANCILLA EDWARD [US]; LAGWINSKA ELIZABETH M [US]


Patent No.: US5399352A  Issued: 21/Mar/1995

Title: Device for local drug delivery and methods for using the same

Applicant/Assignee: EMORY UNIVERSITY

Application No.: 46622   Filing Date: 14/Apr/1993

Abstract:

A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

Priority:

Inventor: HANSON STEPHEN R [US]


Patent No.: US5403304A  Issued: 04/Apr/1995

Title: Blood collection device

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 161205   Filing Date: 02/Dec/1993

Abstract:

A blood collection device having a blood-collecting tube, a needle, a blood container connected to the needle by the blood-collecting tube. The blood container has a blood-storing space containing anticoagulant solution. Two blood-component containers and an erythrocyte-preserving solution container are connected to the blood container by a blood-component supplying tube and a tube. The containers are made of soft material. A branching member is coupled to the blood-collecting tube and located between the blood container and the needle. A tube branching from the blood-collecting tube is connected to a filter. The filter allows passage of gas but substantially prevents passage of blood, bacteria, microorganism and the like. A flow stopper connects the blood-collecting tube to the filter. The flow stopper comprises a breakable member closing the branch tube. When the breakable member is broken, the branch tube communicates with the filter.

Priority: JP19900116183 Applic. Date: 1990-05-02; US1991-693342 Applic. Date: 1991-04-30

Inventor: ISHIDA NOBORU [JP]


Patent No.: US5405607A  Issued: 11/Apr/1995

Title: Method for preparing fibrinogen adhesive from whole blood

Applicant/Assignee:

Application No.: 90587   Filing Date: 12/Jul/1993

Abstract:

A process and apparatus for one-step preparation of the fibrinogen component of an adhesive is described. The fibrinogen is precipitated directly from plasma using polyethylene glycol. This permits preparation of autologous fibrinogen from the patient during surgery which can be combined with calcium, ion and thrombin and used as an adhesive.

Priority: US1989-372443 Applic. Date: 1989-06-23

Inventor: EPSTEIN GORDON H [US]


Patent No.: US5407425A  Issued: 18/Apr/1995

Title: System for the collecting and retransfusion of autologous blood

Applicant/Assignee:

Application No.: 297922   Filing Date: 31/Aug/1994

Abstract:

In a closed system for collecting and retransfusing autologous blood having a collecting vessel (4) to receive the blood and an anticoagulant fluid, as well as a retransfusion line (14, 14') containing a microfilter, through which at least a portion of the blood collected in the collecting vessel (4) is retransfused, the inlet for the anticoagulant fluid is provided, preferably between the collecting vessel (4) in which a negative pressure can be maintained and a drain (2) or the open end of a drain tube. The collecting vessel (4) is connected with a collecting and separating container (13, 13') by means of a tube line (10, 10'), to which a tube pump (11) can be applied. The retransfusion line (14, 14') for the erythrocyte concentrate deposited in the collecting and separating container (13, 13') is connected to the outlet thereof.

Priority: DE19893943300 Applic. Date: 1989-12-29; US1990-629579 Applic. Date: 1990-12-18

Inventor: WERNER MARGRIT [DE]; SCHUETT KLAUS-HERMANN [DE]


Patent No.: US5407803A  Issued: 18/Apr/1995

Title: Method for measuring the activity of angiotensin converting enzyme in biological samples

Applicant/Assignee: B.M.R.A. CORPORATION B.V

Application No.: 830341   Filing Date: 31/Jan/1992

Abstract:

The activity of angiotensin converting enzyme (ACE) is measured in biological samples as body fluids. ACE-activity is estimated in minimally diluted specimens, using the natural substrate angiotensin I at close to physiological concentration. Femtomoles of generated angiotensin II are trapped by specific high affinity monoclonal antibodies and thus protected from degradation by angiotensinases during the incubation step. The same antibodies are subsequently used for quantitation by radioimmunoassay.

Priority: EP19910810074 Applic. Date: 1991-02-01

Inventor: BRUNNER HANS R [CH]; NUSSBERGER JUERG [CH]


Patent No.: US5411472A  Issued: 02/May/1995

Title: Low trauma blood recovery system

Applicant/Assignee: GALEN MEDICAL, INC

Application No.: 922566   Filing Date: 30/Jul/1992

Abstract:

Recovery of blood from a wound site (12) during a surgical procedure is accomplished with low blood trauma that enables collection of increased amounts of blood having relatively little structural damage for return to the surgical patient. Blood trauma is decreased by accelerating liquid blood from the wound site to flow at a relatively low velocity with a relatively high negative gauge pressure and accelerating a mixture of blood and foam from the wound site to flow at a relatively high velocity and a relatively low negative gauge pressure. A suction wand is provided in which liquid blood (32) is separated from a mixture of blood and foam (16) at the wound site through the transport of the two separated fluids at the different velocities and negative gauge pressures. The wand includes an outer blood foam tube within which are three resiliently compressed, side-by-side tubes for handling liquid blood, rinse solution and anticoagulant. Low fluidic capacitance filter defoamer modules, having built-in diaphragm operated pumps, receive and filter recovered liquid blood and foam blood for transfer to separate storage bags.

Priority:

Inventor: STEG JR ROBERT F [US]; PETERSON DEAN M [US]; CUSI DANTE S [MX]


Patent No.: US5417681A  Issued: 23/May/1995

Title: Medical container device and method for manufacturing same

Applicant/Assignee: TERUMO KABUSHIKI KAISHA

Application No.: 974163   Filing Date: 10/Nov/1992

Abstract:

A container device comprises a blood-collecting bag, a platelet conserving bag, and a plasma bag. These bags are connected each other by tubes. Anticoagulant agent is contained in the blood-collecting bag, and the other bags are empty. The blood-collecting bag is formed of flexible polyvinylchloride. The blood-collecting bag is autoclaved after containing anticoagulant. The other bags are formed of polyolefin such as EVA, and radiation- or gas-sterilized in an empty state.

Priority: JP19910322507 Applic. Date: 1991-11-11

Inventor: MIYAKE MAKOTO [JP]; ISHIDA NOBORU [JP]


Patent No.: US5419759A  Issued: 30/May/1995

Title: Apparatus and methods for treatment of HIV infections and AIDS

Applicant/Assignee:

Application No.: 68510   Filing Date: 27/May/1993

Abstract:

An extracorporeal apparatus and methods for treatment of HIV (Human Immuno-deficiency Virus) infections and AIDS. Infected blood is drawn from a patient and separated into infected components (comprising plasma, cell-free virus, and infected white cells containing replicating virus) and uninfected components (comprising red cells and platelets). The uninfected components are returned to the patient and the infected components are treated with organic agents. The preferred organic agent is diethyl ether which is used in an amount and over a period of time sufficient to kill the infected cells and the cell-free virus. The preferred apparatus functions at temperatures below 56 DEG C., and includes centrifugal separators for separating the infected components from healthy components

mixers and agitators inside an air-tight chamber void of oxygen where the infected components are mixed and treated with ether

centrifuges and distillators working under vacuum which remove the ether after the completion of treatment

a gas chromatograph with automatic sampling for determining the residues of ether and the safety of the treated components

and mechanisms for returning the treated and safe components, in conjunction with intravenous fluids, separately or together with the healthy components, to the patient. The treatment cycle is repeated until the patient's blood is made free of virus.

Priority: US1988-272535 Applic. Date: 1988-11-17

Inventor: NAFICY SADEQUE S [US]


Patent No.: US5421812A  Issued: 06/Jun/1995

Title: Method and apparatus for controlling concentrations in tubing system

Applicant/Assignee: COBE LABORATORIES, INC

Application No.: 845677   Filing Date: 04/Mar/1992

Abstract:

A method and apparatus for determining, controlling or establishing the level of a constituent such as anticoagulant in a body fluid such as blood in a procedure for processing the fluid. The anticoagulant flow rate from an anticoagulant reservoir, the blood flow rate, the flow rate of collected fluid and the flow rate of replacement fluid are monitored, and an anticoagulant flow balance is established whereby the flow of anticoagulant into the donor or patient will be equal to the flow rate of anticoagulant out of the anticoagulant reservoir, plus the flow rate of anticoagulant from the donor or patient, plus the flow rate of anticoagulant in the replacement fluid, minus the flow rate of anticoagulant in the collect fluid. The flow rate of anticoagulant from the donor or patient can be determined based on the anticoagulant metabolic half-life, the volume of the donor's or patient's blood, and the amount and time of infusion of anticoagulant into the donor or patient.

Priority:

Inventor: LANGLEY ROBERT W [US]; SCHWAB MICHAEL E [US]


Patent No.: US5421815A  Issued: 06/Jun/1995

Title: Method for blood dialysis using anticoagulent composition

Applicant/Assignee: NOF CORPORATION

Application No.: 167221   Filing Date: 14/Dec/1993

Abstract:

An anticoagulant composition for a blood dialysis circuit contains a fatty acid derivative in liquid form at ambient temperature, and an antioxidant. The antioxidant is contained in an amount of 0.0001 to 5.0 parts by weight relative to 100 parts by weight of the fatty acid derivative. An air trap chamber device for a blood dialysis circuit contains a vessel for storing blood dialysed by a dialysis unit, an inlet tube for introducing the blood treated with dialysis into a liquid in the vessel selected from the group consisting of a layer of the aforementioned anticoagulant composition, and the blood, a measurement unit for measuring the pressure of air in the vessel lying above the layer of the anticoagulant composition, an adjustment unit for adjusting the pressure of the air and an outlet tube for conducting the blood treated with dialysis out of the vessel. A method for blood dialysis involves passing blood taken out of a mammal through the aforementioned vessel in which the blood and air are not in contact with each other, and returning the blood into the mammal.

Priority: EP19930403056 Applic. Date: 1993-12-16

Inventor: NOGUCHI YASUHISA [JP]; KASAMA TOSHIO [JP]


Patent No.: US5426031A  Issued: 20/Jun/1995

Title: Extraction methods for preparing thromboplastin reagents

Applicant/Assignee: BAXTER DIAGNOSTICS INC

Application No.: 70875   Filing Date: 25/May/1993

Abstract:

The Prothrombin Time (PT) is used as a screening test for blood coagulation factor deficiencies and for monitoring oral anti-coagulant therapy using coumadin. Thromboplastin reagents activate the extrinsic pathway of coagulation and are the basis for the Prothrombin Time (PT) test. This invention describes the use of barium sulfate and chaotropic agents, and nonionic detergents, for the extraction of sensitive thromboplastin reagents from tissue. Extraction with sodium thiocyanate alone also greatly enhances thromboplastin sensitivity. This invention should be useful for all thromboplastins and will improve their sensitivity for all PT-based tests and specific assays.

Priority: US1990-632894 Applic. Date: 1990-12-24; US1988-276083 Applic. Date: 1988-11-23

Inventor: HAWKINS PAMELA L H [US]; MAYNARD JAMES R [US]


Patent No.: US5439460A  Issued: 08/Aug/1995

Title: Cross-spike prevention system

Applicant/Assignee:

Application No.: 117729   Filing Date: 07/Sep/1993

Abstract:

An improved device and process of assuring separation of an anticoagulant type fluid from a saline type fluid each of which is utilized in the process and operation of a plasmapheresis apparatus or the process of collecting donor blood, is disclosed. The improvement includes a cross-spike prevention receptacle which is dimensioned, and installed positionally in reference to a plasmapheresis or blood donor apparatus, to receive an anticoagulant fluid container to which a proper respective supply communication line will connect, and to exclude and not receive a saline fluid container or container holding a similiar type of fluid, whose fluid line will not reach and connect to the installed cross-spike prevention receptacle. As a part of the process and concepts of the invention the supply containers or bags of fluids which are supplied for use with the invention are provided so that the respective anticoagulant bags are smaller in volume capacity and size than the respective saline solution container bags used in the plasmapheresis or blood collection process, and the bags are dimensioned so that the saline container or bag will not fit into the cross-spike prevention receptacle even upon substantial forcing or where such force would cause rupture of the container or would otherwise result in a container in a condition which could not be reasonably used with respect to the plasmapheresis or blood collection process.

Priority:

Inventor: HOOVER BRYAN J [US]


Patent No.: US5441482A  Issued: 15/Aug/1995

Title: Jet driven surgical suction device and method of using

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF MINNESOTA

Application No.: 241284   Filing Date: 11/May/1994

Abstract:

A probe for use in collecting liquids entrained with a gaseous component, particularly collecting a patient's blood with entrained gas bubbles from a surgical site for autologous reinfusion. The probe separates the gaseous component from the collected liquid, particularly separating air bubbles from blood cells to inhibit hemolysis, platelet degradation and protein denaturation. An elongated probe body has a distal end to be inserted into the liquid to be collected through an inlet by jet pump action into a centrally disposed mixing chamber. A diffuser is formed within the probe body proximal to and in axial alignment with the inlet and mixing chamber leading to a liquid exit. A jet pump nozzle is formed in the probe distal tip surrounding the inlet in the form of an annular chamber into which pressurized drive fluid is introduced through a distribution channel system extending along the probe body from the proximal end. The drive fluid is ejected in a swirling vortex from the jet pump nozzle around the periphery of the mixing chamber effecting a sub-atmospheric pressure for suctioning the liquid to be collected and the gaseous component thereof into the inlet and mixing chamber. The drive fluid mixes therewith in the swirling vortex and propels the mixture into the diffuser while concentrating the gaseous component in the center of the swirling vortex as a stream. A gas evacuation tube is oriented in the centrally disposed concentrated gaseous stream for evacuating the gaseous component from the mixture before it is propelled into the diffuser. In the autologous reinfusion context, the entrained air bubbles are concentrated and removed in the probe from the blood as they are suctioned into the swirling vortex to reduce hemolysis. When mixed in the vortex, the blood and drive fluid mixture is pressurized to inhibit further air bubble formation.

Priority:

Inventor: CLAGUE CYNTHIA T [US]; BLACKSHEAR JR PERRY L [US]


Patent No.: US5441892A  Issued: 15/Aug/1995

Title: Blood clot mass measuring technique

Applicant/Assignee: MEDTRONIC HEMPTEC, INC

Application No.: 962486   Filing Date: 15/Oct/1992

Abstract:

A clot mass condition of blood is evaluated by initially forming the clot in the sample of the blood and thereafter allowing the clot to condense. The initial formation of the clot is determined by measuring the drop time of a reciprocated indicator device upon which the clot is formed. The condensation of the clot is determined by measuring the stabilized and increased drop time of the indicator device after the initial clot formation has occurred. The clot mass is related to the quantity of fibrinogen in the blood sample which polymerizes in the clot. Clot condensation results in the clot being substantially only fibrinogen, so the stabilized condensation time is related to the fibrinogen concentration in the blood sample.

Priority:

Inventor: BAUGH ROBERT F [US]


Patent No.: US5451578A  Issued: 19/Sep/1995

Title: Fibrinogen receptor antagonists

Applicant/Assignee: MERCK & CO., INC

Application No.: 289974   Filing Date: 12/Aug/1994

Abstract:

Compounds of the invention have the formula: which have fibrinogen receptor antagonist activity, including, for example,

Compounds of the invention have the formula: which have fibrinogen receptor antagonist activity, including, for example,

Priority:

Inventor: CLAREMON DAVID A [US]; LIVERTON NIGEL [US]; BALDWIN JOHN J [US]


Patent No.: US5455039A  Issued: 03/Oct/1995

Title: Extraluminal regulation of the growth and repair of tubular structures in vivo

Applicant/Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Application No.: 225429   Filing Date: 08/Apr/1994

Abstract:

A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.

Priority: US1991-769162 Applic. Date: 1991-09-27; US1989-436337 Applic. Date: 1989-11-13

Inventor: EDELMAN ELAZER R [US]; ADAMS DAVID H [US]; KARNOVSKY MORRIS J [US]


Patent No.: US5456885A  Issued: 10/Oct/1995

Title: Fluid collection, separation and dispensing tube

Applicant/Assignee:

Application No.: 90329   Filing Date: 12/Jul/1993

Abstract:

A tube for collection, separation and dispensation of a two-phase fluid is provided with a elongated rigid tubular container having a fluid entry end a closable end and a float. The float retained within the tubular container is positioned between the light phase and the heavy phase of the fluid on centrifugation thereby separating the two phases. In dispensing the light phase, the float moves to and engages the fluid entry end thereby preventing the heavy phase from escaping out of the tube.

Priority:

Inventor: COLEMAN CHARLES M [US]; KENDRICK WILLIAM [US]


Patent No.: US5460607A  Issued: 24/Oct/1995

Title: Balloon catheter

Applicant/Assignee: NIPPON ZEON CO., LTD

Application No.: 125843   Filing Date: 24/Sep/1993

Abstract:

A balloon catheter used for intra-aortic balloon pumping (IABP). In the balloon catheter, an outer diameter of a catheter tube is not made constant in the axial direction. Rather, the outer diameter of the catheter tube from a hemostatic valve to a bifurcation, the portion which is positioned outside the patient's blood vessel, is made 3 to 30 percent larger than the outer diameter of the catheter tube from the balloon portion to the hemostatic valve, which is positioned inside the patient's blood vessel. The bifurcation has a first passage and a second passage. The first passage is communicating with a shuttle gas port and is disposed straight along the direction of the axial center of the catheter tube. In the balloon catheter, improvements in a channel resistance of a shuttle gas and in the response can be expected compared with the conventional balloon catheter, where the blood pressure measurement port (the second passage) was disposed straight along the direction of the axial center of the catheter tube and the outer diameter of the catheter tube was made constant in the axial direction.

Priority: JP19920285093 Applic. Date: 1992-09-30; JP19920285094 Applic. Date: 1992-09-30; JP19920343355 Applic. Date: 1992-11-30; JP19920343356 Applic. Date: 1992-11-30

Inventor: MIYATA SHINICHI [JP]; KAWABATA TAKASHI [JP]; TOYOKAWA TETSUO [JP]; SAKAI KOUICHI [JP]


Patent No.: US5466234A  Issued: 14/Nov/1995

Title: Expandable laser catheter

Applicant/Assignee: TRIMEDYNE, INC

Application No.: 189375   Filing Date: 31/Jan/1994

Abstract:

A catheter suitable for the delivery of laser energy to an obstruction in a body lumen is provided, which has an expandable, elastic distal end portion containing optical fibers whose exposed distal end faces are arranged in two or more substantially concentric arrays that merge into a narrower band array of a larger diameter upon radial expansion of the elastic distal end portion. The distal end portion of the catheter is more elastomeric than the catheter body.

Priority:

Inventor: LOEB MARVIN P [US]; SHAOLIAN SAMUEL M [US]; SAADATMANESH VAHID [US]; GIBA JEFFREY J [US]; PHAM TO V [US]


Patent No.: US5472852A  Issued: 05/Dec/1995

Title: Assay for detection of selective Protein C inhibition by patients

Applicant/Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATION

Application No.: 121944   Filing Date: 15/Sep/1993

Abstract:

An assay useful for detecting the propensity of patients for thrombotic disease, especially patients having the lupus anticoagulant or antiphospholipid antibodies, is described. The assay is conducted on patient and control plasma in the presence and absence of exogenous Protein C with a membrane source comprising phosphatidylethanolamine and phosphatidylserine. Patients at risk exhibit test results indicating activated Protein C function is inhibited.

Priority:

Inventor: SMIRNOV MIKHAIL D [US]; ESMON CHARLES T [US]


Patent No.: US5474891A  Issued: 12/Dec/1995

Title: Plasma-based platelet concentrate preparations with additive

Applicant/Assignee: THOMAS JEFFERSON UNIVERSITY

Application No.: 262045   Filing Date: 16/Jun/1994

Abstract:

The present invention provides a composition and method for improving the storage of platelets and optimizing the viability of stored platelets. The present invention allows platelets to be stored in plasma for extended periods, without the addition of buffer, by adding storage extension additives, which include acetate, pyruvate, acetoacetate, beta -hydroxybutyrate, acetone, alpha -ketoglutarate, succinate, fumarate, malate, oxaloacetate, C3-8 fatty acid anions, triose phosphates and mixtures thereof, to a platelet concentrate.

Priority: US1993-043574 Applic. Date: 1993-04-07; US1991-784695 Applic. Date: 1991-10-30

Inventor: MURPHY SCOTT [US]


Patent No.: US5476509A  Issued: 19/Dec/1995

Title: Articles having graft polymer bioactive surfaces

Applicant/Assignee: MEDTRONIC, INC

Application No.: 255632   Filing Date: 09/Jun/1994

Abstract:

Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm), and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.

Priority: US1992-969692 Applic. Date: 1992-10-30

Inventor: KEOGH JAMES R [US]; HOBOT CHRISTOPHER M [US]; EATON JOHN W [US]; JEVNE ALLAN H [US]; BERGAN MATTHEW A [US]


Patent No.: US5476764A  Issued: 19/Dec/1995

Title: Method using CO for extending the useful shelf-life of refrigerated red blood cells

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 308028   Filing Date: 16/Sep/1994

Abstract:

Method using CO for extending the useful shelf-life of refrigerated red blood cells. Carbon monoxide is utilized for stabilizing hemoglobin in red blood cells to be stored at low temperature. Changes observed in the stored cells are similar to those found in normal red cell aging in the body, the extent thereof being directly related to the duration of refrigerated storage. Changes in cell buoyant density, vesiculation, and the tendency of stored cells to bind autologous IgG antibody directed against polymerized band 3 IgG, all of which are related to red blood cell senescence and increase with refrigerated storage time, have been substantially slowed when red blood cells are treated with CO. Removal of the carbon monoxide from the red blood cells is readily and efficiently accomplished by photolysis in the presence of oxygen so that the stored red blood cells may be safely transfused into a recipient.

Priority:

Inventor: BITENSKY MARK W [US]


Patent No.: US5478479A  Issued: 26/Dec/1995

Title: Two-stage cell wash process controlled by optical sensor

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 246787   Filing Date: 20/May/1994

Abstract:

A method of washing salvaged blood includes separating higher density blood components from lower density blood components within a rotating centrifuge bowl. The separated blood components are washed with wash solution to remove free hemoglobin (Hgb), anticoagulant, cellular debris and other undesirable elements from the blood components. The previously separated blood components are re-suspended by braking the rotation of the centrifuge bowl to release the free Hgb, and other undesirable elements trapped in the red blood cell layer. The higher density blood components are then re-separated from the lower density blood components within the centrifuge bowl. The re-separated blood components are again washed with wash solution to further remove free Hgb and other undesirable elements from the blood components.

Priority:

Inventor: HERRIG RUSSELL [US]


Patent No.: US5484396A  Issued: 16/Jan/1996

Title: Method and device for treatment of HIV infections and AIDS

Applicant/Assignee:

Application No.: 272535   Filing Date: 17/Nov/1988

Abstract:

A method and device are disclosed for treatment of HIV (Human Immuno-deficiency virus) infections and AIDS. The method consists of separating the blood, in an extracorporeal device, into an infected component and a healthy component. The healthy component including red cells and platelets is returned to the patient. The infected component, consisting of infected plasma with cell-free virus and infected white cells containing replicating virus, is treated with organic solvents. In the preferred embodiment the organic solvent used is diethyl ether. The ether will dissolve the lipid-containing envelope of the cell-free virus and will subsequently kill the virus. The ether will also kill the infected cells containing replicating virus, thus it will stop the maturation and budding of the virus which would otherwise occur at the cell-membrane. Diethyl ether which is highly volatile and has a boiling point of only 34.43 DEG C. is then removed from the treated blood or plasma by distillation under vacuum at temperatures below 56 DEG C. without destroying or damaging the blood factors, complement, antibodies, enzymes, etc. Alternatively the ether or the residual ether is removed by centrifuge and vacuum. The plasma thus made free of viable virus and viable infected cells is then returned to the patient. The treatment cycle is repeated until the entire patient's blood is made substantially free of virus.

Priority:

Inventor: NAFICY SADEQUE S [US]


Patent No.: US5494590A  Issued: 27/Feb/1996

Title: Method of using anticoagulant solution in blood separation

Applicant/Assignee: BECTON DICKINSON

Application No.: 897305   Filing Date: 11/Jun/1992

Abstract:

An anticoagulant solution of sodium citrate for use in blood chemistry-related techniques and apparatus is disclosed. The anticoagulant solution should include an effective concentration of sodium citrate sufficient for preventing the coagulation of a sample of blood employed in the technique or added to the apparatus. The sodium citrate-based anticoagulant solution should have a pH ranging from above 6.0 to about 8.5 and a sodium citrate concentration preferably ranging from about 0.05M to about 0.2M.

Priority:

Inventor: SMITH WARD C [US]; CARROLL RICHARD J [US]


Patent No.: US5494592A  Issued: 27/Feb/1996

Title: Apheresis apparatus and method

Applicant/Assignee: HAEMONETICS CORPORATION

Application No.: 372890   Filing Date: 13/Jan/1995

Abstract:

An apheresis apparatus and method is disclosed for increasing the purity and yield of platelets separated from donated whole blood in a centrifuge. The whole blood in the centrifuge is diluted by recirculating fluid, such as plasma or saline, at a first flow rate, to mix with further withdrawn whole blood prior to entering the centrifuge. As plasma is collected, it is recirculated through the centrifuge at a second flow rate to further improve the separation between the intermediate density components, i.e., platelets and white blood cells in the "buffy coat." The plasma is then recirculated through the centrifuge at a third flow rate and platelets are displaced out of the centrifuge while the plasma is recirculating through the centrifuge at the third flow rate.

Priority: US1993-053734 Applic. Date: 1993-04-27

Inventor: LATHAM JR ALLEN [US]; JORGENSEN GLEN E [US]; SIBINGA THEODOOR H S [US]; PLANTE JOSEPH R [US]; KNAPP TRACEY E [US]


Patent No.: US5496265A  Issued: 05/Mar/1996

Title: Blood component collection system with optimizer

Applicant/Assignee: COBE LABORATORIES, INC

Application No.: 140254   Filing Date: 21/Oct/1993

Abstract:

A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Priority: US1993-110432 Applic. Date: 1993-08-23; US1992-845677 Applic. Date: 1992-03-04; US1992-912973 Applic. Date: 1992-07-10

Inventor: LANGLEY ROBERT W [US]; KELLER JOHN J [US]; URDAHL STEVEN G [US]


Patent No.: US5496821A  Issued: 05/Mar/1996

Title: Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them

Applicant/Assignee: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A

Application No.: 253275   Filing Date: 02/Jun/1994

Abstract:

Solutions which contain L-carnitine and alkanoyl L-carnitine are useful for stabilizing blood for transfusions.

Priority: IT1993RM00364 Applic. Date: 1993-06-02

Inventor: ARDUINO ARDUINI [IT]


Patent No.: US5498422A  Issued: 12/Mar/1996

Title: Sustained release capsule

Applicant/Assignee: NIPPON SHINYAKU COMPANY LIMITED

Application No.: 129187   Filing Date: 07/Oct/1993

Abstract:

PCT No. PCT/JP92/00423 Sec. 371 Date Oct. 7, 1993 Sec. 102(e) Date Oct. 7, 1993 PCT Filed Apr. 6, 1992 PCT Pub. No. WO92/17166 PCT Pub. Date Oct. 15, 1993.A sustained release capsule excellent in adhesion characteristics in the gastrointestinal tract, stability and so on is provided. The capsule is characterized in that a polymer excellent in initial adhesion and a polymer excellent in shape-retaining ability are dispersed in a liquid substance in the capsule, that a physiologically active substance is dispersed or dissolved in the liquid substance and that the moisture content in the whole preparation is not more than 2%.

Priority: JP19910103846 Applic. Date: 1991-04-08; WO1992JP00423 Applic. Date: 1992-04-06

Inventor: NAKAMICHI KOUICHI [JP]; IZUMI SHOGO [JP]; FUKUI HIROSHI [JP]


Patent No.: US5501963A  Issued: 26/Mar/1996

Title: Amplification and detection of nucleic acids in blood samples

Applicant/Assignee: HOFFMANN-LA ROCHE INC

Application No.: 118534   Filing Date: 08/Sep/1993

Abstract:

This invention relates to a process for the amplification of nucleic acids in the form of DNA or RNA from blood samples by means of an enzymatic amplification method, characterized in that no preparation of the blood sample otherwise necessary to prepurify the nucleic acid to be amplified is performed and the proportion of the sample in the reaction mixture for the amplification process is greater than 5 volume % if a specific amount of salt is present in the reaction mixture. Depending on the proportion of blood sample and its salt contribution of monovalent and/or bivalent ions, the salt concentration in the reaction mixture in which the amplification is performed is, where applicable, adapted to the enzyme requirements by the use of an appropriately concentrated salt solution.

Priority: CH19920002875 Applic. Date: 1992-09-11

Inventor: BURCKHARDT JEAN [CH]


Patent No.: US5504011A  Issued: 02/Apr/1996

Title: Portable test apparatus and associated method of performing a blood coagulation test

Applicant/Assignee: INTERNATIONAL TECHNIDYNE CORPORATION

Application No.: 327320   Filing Date: 21/Oct/1994

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

Priority:

Inventor: GAVIN MICHAEL [US]; CIMINI CATHERINE M [US]; HUANG MING [US]; KUKLO JR ANTHONY [US]; MAWHIRT JAMES A [US]; MARCELINO EDUARDO [US]; SIMONE ALBERT [US]


Patent No.: US5508201A  Issued: 16/Apr/1996

Title: Method for diagnosing the presence or absence of oncological disease

Applicant/Assignee: HANADER MEDICAL CORPORATION

Application No.: 38347   Filing Date: 19/Mar/1993

Abstract:

The invention pertains to a method for diagnosing oncological diseases wherein an effective small amount of blood is obtained, such as from a finger, and a solution containing blood plasma or serum is exposed to laser radiation and the values of one or more parameters are determined upon measurements at molecular level. Said parameters are then compared with analogous measured or established parameters of a reference solution to determine whether there are significant variations or similarities which indicate the absence or presence of oncological diseases or a predisposition to same. In a preferred embodiment of the invention, blood plasma or serum is diluted in water up to 25% of the volume and the solution is then exposed to laser radiation in the standard mode. Measurements and determinations are then made of the coefficient of Rayleigh light scattering "R" in the solution and other indicative parameters such as the effective mass "M" and a parameter of molecular interaction "B" of scattered particles in the solution. The values of R, M and B are then compared with respective reference indicative parameters Rref, Mref and Bref of a calculated or established reference standard or a reference solution, such as one obtained from the blood serum of healthy individuals. If R/Rref>2, M>Mref and B

Priority:

Inventor: BRANDT NICOLAI B [RU]; PETROUSEVICH YURI M [RU]; PETROVA GALINA P [RU]; PAPPYSH ELANA A [RU]; FAROUQE HAFEZ T [US]; KASPARIAN KASPAR A [US]


Patent No.: US5509895A  Issued: 23/Apr/1996

Title: Air trap chamber device for blood dialysis circuit containing an anticoagulant composition

Applicant/Assignee: NOF CORPORATION

Application No.: 460990   Filing Date: 05/Jun/1995

Abstract:

An anticoagulant composition for a blood dialysis circuit contains a fatty acid derivative in liquid form at ambient temperature, and an antioxidant. The antioxidant is contained in an amount of 0.0001 to 5.0 parts by weight relative to 100 parts by weight of the fatty acid derivative. An air trap chamber device for a blood dialysis circuit contains a vessel for storing blood dialysed by a dialysis unit, an inlet tube for introducing the blood treated with dialysis into a liquid in the vessel selected from the group consisting of a layer of the aforementioned anticoagulant composition, and the blood, a measurement unit for measuring the pressure of air in the vessel lying above the layer of the anticoagulant composition, an adjustment unit for adjusting the pressure of the air and an outlet tube for conducting the blood treated with dialysis out of the vessel. A method for blood dialysis involves passing blood taken out of a mammal through the aforementioned vessel in which the blood and air are not in contact with each other, and returning the blood into the mammal.

Priority: US1993-167221 Applic. Date: 1993-12-14

Inventor: NOGUCHI YASUHISA [JP]; KASAMA TOSHIO [JP]


Patent No.: US5510115A  Issued: 23/Apr/1996

Title: Method and composition for administration of beneficial agent by controlled dissolution

Applicant/Assignee: BAXTER TRAVENOL LABORATORIES, INC

Application No.: 351971   Filing Date: 08/Dec/1994

Abstract:

An anhydrous solid water-soluble composition and method for direct controlled administration of beneficial agents to a flowing medical fluid. The beneficial agents are geometrically dispersed in a solid matrix and isolated from one and other to allow administration of mutually reactive agents.

Priority: US1993-080399 Applic. Date: 1993-06-21; US1989-345334 Applic. Date: 1989-05-01; US1987-120892 Applic. Date: 1987-11-16; US1987-121316 Applic. Date: 1987-11-16

Inventor: BREILLATT JR JULIAN P [US]; WOO LECON [US]; NELSON DEANNA J [US]; APPL RICHARD [US]; WEINLESS NAOMI L [US]; POKROPINSKI SHARON [US]; SOLTYS PAUL [US]; BARENBERG SUMNER A [US]


Patent No.: US5512291A  Issued: 30/Apr/1996

Title: Method of making resorbable vascular wound dressing

Applicant/Assignee:

Application No.: 297926   Filing Date: 31/Aug/1994

Abstract:

The present invention is related to prostheses, their methods of manufacture and methods for repairing vascular lesions using such prostheses. Natural polymers such as collagen are processed and fabricated to form tubular resorbable vascular wound dressings with unique physico-chemical and mechanical properties for repairing selected vascular segments, and for delivering therapeutic agents at selected sites within vessels and at the anastomoses.

Priority: CA19942199951 Applic. Date: 1994-09-14; US1993-046895 Applic. Date: 1993-04-15; US1992-821384 Applic. Date: 1992-01-13; WO1994US10423 Applic. Date: 1994-09-14

Inventor: LI SHU-TUNG [US]


Patent No.: US5523092A  Issued: 04/Jun/1996

Title: Device for local drug delivery and methods for using the same

Applicant/Assignee: EMORY UNIVERSITY

Application No.: 188248   Filing Date: 28/Jan/1994

Abstract:

A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

Priority: US1993-046622 Applic. Date: 1993-04-14

Inventor: HANSON STEPHEN R [US]; SCOTT NEAL A [US]; KING III SPENCER B [US]; HARKER LAURENCE A [US]


Patent No.: US5527532A  Issued: 18/Jun/1996

Title: Extraluminal regulation of the growth and repair of tubular structures in vivo

Applicant/Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Application No.: 105903   Filing Date: 02/Sep/1993

Abstract:

A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue. Administration of substances such as heparin over sustained, prolonged periods controls intimal hyperplasia and smooth muscle cell proliferation, even at doses that are insufficient to have such a beneficial effect if administered systemically. Bolus administration of such compounds at higher doses typically used to achieve systemic effects may have no effect or may even produce adverse effects.

Priority: US1991-656182 Applic. Date: 1991-02-27; US1989-436337 Applic. Date: 1989-11-13

Inventor: EDELMAN ELAZER R [US]; ADAMS DAVID H [US]; KARNOVSKY MORRIS J [US]


Patent No.: US5533518A  Issued: 09/Jul/1996

Title: Blood collection assembly including mechanical phase separating insert

Applicant/Assignee: BECTON, DICKINSON AND COMPANY

Application No.: 231548   Filing Date: 22/Apr/1994

Abstract:

A blood collection assembly includes a tube, which may be evacuated, and an insert therein. The insert is descendably affixed to the tube wall and, after separating a blood sample taken in the tube into solid and liquid phases, descends during centrifugation and comes to rest at the solid-liquid interface on a projection from the tube bottom. An interior surface of the assembly may be modified to render it clot activating. The invention includes a method for preparing a blood sample for analysis using the assembly.

Priority:

Inventor: VOGLER ERWIN A [US]


Patent No.: US5534226A  Issued: 09/Jul/1996

Title: Portable test apparatus and associated method of performing a blood coagulation test

Applicant/Assignee: INTERNATIONAL TECHNIDYNE CORPORATION

Application No.: 424063   Filing Date: 19/Apr/1995

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined device of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing consol agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

Priority: US1994-327320 Applic. Date: 1994-10-21

Inventor: GAVIN MICHAEL [US]; CIMINI CATHERINE M [US]; HUANG MING [US]; KUKLO JR ANTHONY [US]; MAWHIRT JAMES A [US]; MARCELINO EDUARDO [US]


Patent No.: US5534270A  Issued: 09/Jul/1996

Title: Method of preparing stable drug nanoparticles

Applicant/Assignee: NANOSYSTEMS LLC

Application No.: 386028   Filing Date: 09/Feb/1995

Abstract:

Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclaving and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

Priority:

Inventor: DE CASTRO LAN [US]


Patent No.: US5541161A  Issued: 30/Jul/1996

Title: Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin

Applicant/Assignee: MERRELL PHARMACEUTICALS INC

Application No.: 123576   Filing Date: 17/Sep/1993

Abstract:

This invention relates to peptide derivatives which are useful anticoagulant agents.

Priority: US1992-963243 Applic. Date: 1992-10-19; US1992-859234 Applic. Date: 1992-03-26; US1991-769567 Applic. Date: 1991-10-02; US1990-479317 Applic. Date: 1990-02-13

Inventor: KRSTENANSKY JOHN L [US]; MAO SIMON J T [US]


Patent No.: US5543062A  Issued: 06/Aug/1996

Title: Leukocyte-removing filter device and system and method of using thereof

Applicant/Assignee: ASAHI MEDICAL CO., LTD

Application No.: 559726   Filing Date: 15/Nov/1995

Abstract:

Disclosed is a leukocyte-removing filter device comprising (a) a casing having an inlet for blood and an outlet for leukocyte-removed blood, which are both located in a top portion of the casing, and (b) a filter medium disposed in the casing so as to divide the internal space of the casing into an inlet-side chamber communicated with the inlet and an outlet-side chamber communicated the outlet. By virtue of the locations of the inlet and outlet on the top portion of the filter device, the leukocyte-removing filter device of the present invention is advantageous not only in that the filter device can be fittedly and stably accommodated into a centrifuge cup together with a plurality of blood bags and circuit tubes connecting the filter device and blood bags, so that a centrifugation can be efficiently conducted without the danger of damaging the filter device and the blood bags, but also in that the operation of expelling the air from the filter by filling the filter with blood can be very readily conducted simply by allowing blood to flow into the filter without any additional burdensome operations. The leukocyte-removing system comprising the above-mentioned leukocyte-removing filter device is also disclosed.

Priority: JP19920291950 Applic. Date: 1992-10-07; US1993-132894 Applic. Date: 1993-10-07

Inventor: NISHIMURA TAKAO [JP]


Patent No.: US5549674A  Issued: 27/Aug/1996

Title: Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Application No.: 133436   Filing Date: 08/Oct/1993

Abstract:

A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Renal cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.

Priority: US1992-844758 Applic. Date: 1992-03-02

Inventor: HUMES H DAVID [US]; CIESLINSKI DEBORAH A [US]


Patent No.: US5552267A  Issued: 03/Sep/1996

Title: Solution for prolonged organ preservation

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 350319   Filing Date: 05/Dec/1994

Abstract:

An aqueous solution for organ preservation or maintenance, which contains: a vasodilator in an amount sufficient to maintain vascular homeostasis

D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics

magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics

macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability

potassium ions in a concentration greater than about 110 mM

and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about physiologic pH or above.

Priority: US1994-206197 Applic. Date: 1994-03-03; US1992-863197 Applic. Date: 1992-04-03

Inventor: STERN DAVID M [US]; OZ MEHMET C [US]; NOWYGROD ROMAN [US]; KOGA SHIN [US]; PINSKY DAVID J [US]


Patent No.: US5552323A  Issued: 03/Sep/1996

Title: Method of blending an anticoagulant

Applicant/Assignee:

Application No.: 285054   Filing Date: 03/Aug/1994

Abstract:

A blended heparin salt for use as an anticoagulant in a blood sample, which substantially eliminates a skew in a determined amount of ionized calcium imparted by the heparin in the blood sample. The blended heparin salt comprises a proportional blend of a zinc salt of heparin and a lithium salt of heparin the salts in a ratio of 1-to-a-fractional-value-less-than-one of the zinc salt of heparin to the lithium salt of heparin by weight based on the USP potency of the salts, the fractional value determined by the ratio of the zinc available per unit of USP potency in the zinc salt of heparin to a predetermined amount of zinc per USP potency to be provided by the blended heparin salt. Methods of blending the proportional amounts of the zinc salt and the lithium salt of heparin are disclosed.

Priority:

Inventor: MERCEREAU STEVEN F [US]


Patent No.: US5556643A  Issued: 17/Sep/1996

Title: Anticoagulant compositions

Applicant/Assignee: HYDRITE CHEMICAL CO

Application No.: 171993   Filing Date: 22/Dec/1993

Abstract:

An anticoagulant for blood contains sodium hydroxide, citric acid and sodium hexametaphosphate. A method of preventing the clotting of blood using the anticoagulant also is disclosed.

Priority:

Inventor: BOHANON LEO F [US]; ADAMS ROBERT A [US]; KRUSZKA DANIEL R [US]


Patent No.: US5563158A  Issued: 08/Oct/1996

Title: Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

Applicant/Assignee: THE DUPONT MERCK PHARMACEUTICAL COMPANY

Application No.: 343159   Filing Date: 22/Nov/1994

Abstract:

This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

Priority: US1993-174552 Applic. Date: 1993-12-28

Inventor: DEGRADO WILLIAM F [US]; XUE CHU-BIAO [US]


Patent No.: US5571081A  Issued: 05/Nov/1996

Title: Per-operational autotransfusion suction device

Applicant/Assignee:

Application No.: 182098   Filing Date: 05/Jul/1994

Abstract:

PCT No. PCT/FR92/00420 Sec. 371 Date Jul. 5, 1994 Sec. 102(e) Date Jul. 5, 1994 PCT Filed May 12, 1992 PCT Pub. No. WO92/20380 PCT Pub. Date Nov. 26, 1992A per-operational autotransfusion suction device has a suction cannular 1 with a tabular section nozzle 5, communicating with an inner passage 6, 9 in the cannula, the cannula passage being connected to a blood collecting recipient 41 in which a partial vacuum can be created by a vacuum source, the cannula passage communicating with an anticoagulant supply circuit having an anticoagulant feed control valve 15. The device has an independent vacuum circuit for sucking in only air and is connected to the vacuum source 40, to the blood collection recipient and to the valve. The valve has a vacuum chamber connected to a vacuum circuit 13, the vacuum chamber 49 having a deformable wall connected to a stopper which can close the anticoagulant feed circuit, the stopper being biased towards a closed position by a spring and capable of being biased towards an open position by deformation of the deformable wall when the pressure in the vacuum chamber is sufficiently low. The vacuum circuit communicates with an air vent 14 which can be shut off manually.

Priority: FR19910005760 Applic. Date: 1991-05-13; WO1992FR00420 Applic. Date: 1992-05-12

Inventor: ADHOUTE GERARD [FR]


Patent No.: US5571151A  Issued: 05/Nov/1996

Title: Method for contemporaneous application of laser energy and localized pharmacologic therapy

Applicant/Assignee:

Application No.: 328857   Filing Date: 25/Oct/1994

Abstract:

A method for contemporaneously applying laser energy and locally delivering pharmacologic therapy to a selected site in a body lumen using a liquid core laser angioscope catheter. The method comprises preparing a solution of a pharmacologic agent, inserting the catheter into the lumen, directing the catheter to the site, transmitting visible light to the site, flowing the light transmissive liquid through the catheter, viewing the site, transmitting laser energy through the liquid filled catheter to treat the site, and introducing a flow of the pharmacologic agent in solution into the catheter for contemporaneous discharge at the distal end into the lumen adjacent the site.

Priority:

Inventor: GREGORY KENTON W [US]


Patent No.: US5571506A  Issued: 05/Nov/1996

Title: Aromatic oligomeric compounds useful as mimics of bioactive macromolecules

Applicant/Assignee: RHONE-POULENC RORER PHARMACEUTICALS INC

Application No.: 119456   Filing Date: 10/Sep/1993

Abstract:

This invention relates to aromatic oligomeric compounds useful in the treatment of cardiovascular, bone metabolic, hypolipidaemic, neuronal, gastrointestinal and elastase-mediated connective tissue degradation disorders and disorders which may be treated by agents effective in binding DNA, to processes for preparation of such oligomeric compounds, to pharmaceutical compositions including such oligomeric compounds, and to their use in the treatment of such disorders.

Priority: US1991-703061 Applic. Date: 1991-05-20; US1989-440584 Applic. Date: 1989-11-22; US1989-440586 Applic. Date: 1989-11-22; US1989-393873 Applic. Date: 1989-08-14

Inventor: REGAN JOHN R [US]; MCGARRY DANIEL G [US]; CHANG MICHAEL N [US]; BARTON JEFFREY N [US]; NEWMAN JACK [US]; BEN-SASSON SCHMUEL [IL]


Patent No.: US5573527A  Issued: 12/Nov/1996

Title: Dockable bag system and method

Applicant/Assignee: PALL CORPORATION

Application No.: 456652   Filing Date: 02/Jun/1995

Abstract:

Apparatus and method for sterile docking two or more plastic bag units 110. The invention generally includes a sterilizable pouch 102 manufactured from an essentially vapor transmission resistant material. Contained within the pouch 102 is at least one plastic bag unit 110 and a predetermined amount of sterile tubing 108 connected thereto. The pouch 102 includes an aperture 104 in one wall or at one seam through which a tube fitting 106 protrudes. The tube fitting 106 has an internal diameter sufficient to permit passage therethrough of the tubing 108 contained within the pouch 102 and connected to the bag unit 110 contained therein. The protruding tubing 108 then may be used for docking with other bag units 110.

Priority: US1993-157686 Applic. Date: 1993-11-24

Inventor: MACABASCO AGILIO E [US]; SALUMBIDES RENATO R [US]


Patent No.: US5574012A  Issued: 12/Nov/1996

Title: Analogs of hirudin having anti-platelet activity

Applicant/Assignee: MERRELL PHARMACEUTICALS INC

Application No.: 444618   Filing Date: 19/May/1995

Abstract:

This invention relates to peptide derivatives which are useful anticoagulant agents.

Priority: US1994-255846 Applic. Date: 1994-06-08; US1991-714547 Applic. Date: 1991-06-11; US1990-557289 Applic. Date: 1990-07-24

Inventor: KRSTENANSKY JOHN L [US]; BROERSMA JR ROBERT J [US]


Patent No.: US5578326A  Issued: 26/Nov/1996

Title: Method and an apparatus for preparing tissue repair promoting substances

Applicant/Assignee: E. R. SQUIBB & SONS, INC

Application No.: 440538   Filing Date: 12/May/1995

Abstract:

A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first container of a container system comprising at least first and second interconnected containers

centrifuging the container system containing the blood so as to separate the blood in various fractions including a plasma fraction

transferring at least part of the plasma fraction to the second container of the container system

subjecting the plasma fraction in the second container to a low temperature so as to obtain a precipitate comprising tissue repair promoting substances

concentrating the precipitate in the second container so as to obtain a first fraction comprising a major part of the non-precipitated material, and a second fraction comprising at least the major part of the precipitate and a minor part of the non-precipitated material

and separating the second fraction comprising the tissue repair promoting substances from the first fraction within the second container

and optionally heating the second fraction within one of the containers of the container system so as to dissolve the isolated precipitated tissue repair promoting substances. Fractions comprising tissue repair promoting substances derived from blood cells may also be isolated within the container system, and optionally combined with the second fraction comprising tissue repair promoting substances derived from blood plasma.

Priority: DK19860004753 Applic. Date: 1986-10-03; WO1987DK00117 Applic. Date: 1987-10-02; US1992-998128 Applic. Date: 1992-12-29; US1991-704911 Applic. Date: 1991-05-21; US1990-465530 Applic. Date: 1990-01-17; US1988-216712 Applic. Date: 1988-07-05

Inventor: WEIS-FOGH ULLA S [DK]


Patent No.: US5580789A  Issued: 03/Dec/1996

Title: Method for collecting blood

Applicant/Assignee: AMERICAN HOME PRODUCTS CORPORATION

Application No.: 482995   Filing Date: 07/Jun/1995

Abstract:

A process is disclosed for the production of an anticoagulant composition which allows for the accurate analysis of blood electrolyte concentrations. Also disclosed is the anticoagulant composition produced in accordance with the disclosed method and an apparatus containing the composition useful in the selection and sampling of blood.

Priority: US1994-235622 Applic. Date: 1994-06-29; US1993-096123 Applic. Date: 1993-07-22; US1993-009627 Applic. Date: 1993-01-27

Inventor: MANCILLA EDWARD [US]; LAGWINSKA ELIZABETH M [US]


Patent No.: US5583121A  Issued: 10/Dec/1996

Title: Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes

Applicant/Assignee: MICHIGAN STATE UNIVERSITY GLYCOMED INCORPORATED

Application No.: 251817   Filing Date: 31/May/1994

Abstract:

A method of treating hypovolemic shock and related shock syndromes by the administration of substantially non-anticoagulant heparinoids without the hemorrhaging problems generally associated with heparin

such syndromes include degradation of the microvascular structure, immune and gastrointestinal tract dysfunction, and multiple organ failure.

Priority: US1994-180585 Applic. Date: 1994-01-12

Inventor: CHAUDRY IRSHAD H [US]; HOLME KEVIN R [US]


Patent No.: US5588958A  Issued: 31/Dec/1996

Title: Closed wound orthopaedic drainage and autotransfusion system

Applicant/Assignee: C. R. BARD, INC

Application No.: 310268   Filing Date: 21/Sep/1994

Abstract:

A drainage and autotransfusion system is coupled with a closed wound drain. A detachable suction reservoir provides suction to the system to facilitate drainage of blood from the wound into a substantially rigid collection container. This blood is adapted to be transferred into an attached blood bag which in turn may be coupled with an administration set for reinfusion. While blood is reinfusing, blood collection into the container continues. Following autotransfusion, the suction reservoir can be converted to a suction device for blood collection directly from the closed wound drain.

Priority:

Inventor: CUNNINGHAM ROBERT W [US]; KOCH DURMUS [US]; MURA JANINE R [US]; FELIX AUGUSTUS [US]; HALICK GARY V [US]

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US PATENTS IN BLOOD ANTICLOT TECHNOLOGY GRANTED FROM 1980 TO 1996
This list includes patents granted in the United States. The list was retrieved by searching the claims section of all patent applications. Salient search terms included drugs, medications,
formulation and devices related to blood anticlotting; blood thinners, anticoagulants, protease enzymes, coumadin and thrombin drugs, thrombin inhibitors, heparin, warfarin and related
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