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PCT - WORLD PATENTS AND PUBLICATIONS IN SUNSCREEN FROM 1990 TO 2006


COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS

(WO2006138518) 28.12.2006 A61F 13/00 COMBINATORX, INCORPORATED
The invention features a method for treating a patient diagnosed with, or at risk of developing, an iminunoinflainpiatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
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STABLE SUNSCREEN COMPOSITIONS CONTAINING ZINC OXIDE

(WO2006135463) 21.12.2006 A61K 8/81 AMCOL INTERNATIONAL CORPORATION
A stable, oil-in-water (O-W) emulsion-based sunscreen composition having at least one water-insoluble, organic UV-absorber having a water-solubility of much less than 0.1% by weight, contained in the oil phase of the sunscreen emulsion, comprising i) zinc oxide (ZnO) particles having a surface free of any prior coating of any inorganic oxide and hydrophobic material, remaining dispersed in the water phase of the sunscreen emulsion; ii) at least one non- or low-foaming, non-cationic, hydrophilic polymer, capable of dispersing or deflocculating the ZnO particles but incapable of thickening an aqueous composition to a viscosity of greater than 100 cps at 25C, wherein the viscosity is measured using a Brookfield viscometer operated at 10 r...
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USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES

(WO2006133876) 21.12.2006 A61K 8/49 DSM IP ASSETS B.V.
The present invention is directed to the use of certain pyrimidine derivatives for cosmetic purposes, i.e. for the preparation of a composition for providing a cosmetic effect. It was found that said pyrimidine derivatives are particularly useful for treating wrinkles but also for thickening the epidermis, for improving hair growth and for treating grey hair. The present invention is also directed to a composition containing said pyrimidine derivatives. In particular, said composition is a cosmetic preparation.
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SURFACE TREATMENT COMPOSITIONS COMPRISING SACCHARIDE-SILOXANE COPOLYMERS

(WO2006127882) 30.11.2006 D06M 15/643 DOW CORNING CORPORATION
A surface treatment composition comprising at least one saccharide- siloxane copolymer having a saccharide component and an organosiloxane component and linked by a linking group, wherein the saccharide-siloxane copolymer has a specified formula and the surface treatment composition is adapted to provide at least one benefit to a surface to which it is applied, is provided. Dispersions and emulsions comprising the saccharide-siloxane copolymer, and treatment compositions comprising the emulsions and/or dispersions are also provided. The invention further provides methods and articles of manufacture comprising the inventive compositions.
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REGULATION OF MAMMALIAN KERATINOUS TISSUE USING PERSONAL CARE COMPOSITIONS COMPRISING CETYL PYRIDINIUM CHLORIDE

(WO2006124990) 23.11.2006 A61K 8/37 THE PROCTER &GAMBLE COMPANY
Personal care composition including a first skin and/or hair care active cetyl pyridinium chloride; and at least one additional skin and/or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creat...
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REGULATION OF MAMMALIAN KERATINOUS TISSUE USING SKIN AND/OR HAIR CARE ACTIVES

(WO2006124985) 23.11.2006 A61K 8/63 THE PROCTER &GAMBLE COMPANY
Compositions useful for regulating the condition of mammalian keratinous tissue needing such treatments are provided. An exemplary composition comprises a safe and effective amount of glycyrrhizic acid and/or glycyrrhetinic acid; a safe and effective amount of an active selected from the group consisting of N-acyl amino acid compounds, hexamidine, cetyl pyridinium chloride, ergothioneine, and combinations thereof; and a dermatologically acceptable carrier.
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SKIN CARE COMPOSITIONS CONTAINING IDEBENONE

(WO2006121717) 16.11.2006 A61Q 19/00 THE PROCTER &GAMBLE COMPANY
A stable skin care composition, comprising an effective amount of idebenone, at least one additional skin care active, and a dermatologically acceptable carrier. The composition is substantially colorless.
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TOPICAL COMPOSITION FLUORESCENCE DETECTION

(WO2006118848) 09.11.2006 A61Q 17/04 JOHNSON &JOHNSON CONSUMERS COMPANIES, INC.
Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin. The invention provides a composition comprising at least one topical agent and a fluorescent chromophore having a wavelength of excitation, the topical agent having a first absorbance when measured at said wavelength and the fluorescent chromophore having a second absorbance when measured at said wavelength, wherein the ratio of the second absorbance to the first absorbance is at least about 5. The invention further provides a kit comprising: a) a first composition comprising a topical agent and a first concentration of fluorescent chromophore; and b) a second composition comprising the topical agent and a se...
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TOPICAL COMPOSITION FLUORESCENCE DETECTION

(WO2006118835) 09.11.2006 A61Q 17/04 JOHNSON &JOHNSON CONSUMERS COMPANIES, INC.
Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin. Disclosed is in a first embodiment a composition comprising one or more oil or water soluble ultraviolet sunscreen agents and a fluorescent chromophore, wherein the fluorescent chromophore is oil soluble or water-soluble and has a wavelength of excitation greater than about 400nm (so-called daylight fluorescent compound). Also disclosed is a method of manufacturing a topical composition, comprising mixing a fluorescent chromophore and a sunscreen sufficiently to form a single phase composition. Further, a device for use with the fluorescent composition is described, for determining the presence of the composi...
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SKIN LIGHTENING COMPOSITIONS

(WO2006117430) 09.11.2006 A61Q 19/02 AROMTECH LTD
Invention relates to use of composition comprising at least one triglyceride of at least one unsaturated fatty acid for manufacture of a product for skin lightening. Invention relates also to a skin care composition comprising a dermatologically acceptable additive, and a pure seed oil derived from a plant selected from the group Rubus, Vaccinium, Oxycoccus, Fragaria, Hipphophae, Echium, Hordeum, Avena, or a mixture thereof, and comprising at least one triglyceride of at least one unsaturated fatty acid, excluding seed oil of Rubus chamaemorus. Further, the invention relates to a method for skin lightening for cosmetic purposes.
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SKIN LIGHTENING COMPOSITION COMPRISING A CONJUGATED LINOLEIC ACID AND NIACINAMIDE

(WO2006117055) 09.11.2006 A61K 8/36 UNILEVER PLC
A cosmetic skin lightening composition comprising: (i) 0.01 to 10% by weight of a conjugated linoleic acid and/or its derivatives; and (ii) 0.1 to 10% by- weight niacinamide .
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TUNABLE SUNBLOCK AGENTS

(WO2006116567) 02.11.2006 G02B 5/22 BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Compositions for protecting an object from electromagnetic radiation exposure is disclosed. In certain embodiments, the composition can include a plurality of differen crystalline colloidal arrays, the arrays comprising particles dispersed within a matrix. At leas one of the different crystalline colloidal arrays can randomly orientate within the composition
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PERSONAL CARE COMPOSITIONS COMPRISING SILICONE RESINS WITH ENHANCED PROPERTIES, METHOD OF MANUFACTURE, AND METHOD OF USE THEREOF

(WO2006112865) 26.10.2006 A61K 8/891 GENERAL ELECTRIC COMPANY
A personal care composition comprising a silicone resin of the generic formula: MQ, wherein the ratio of M to Q is about from 0.01/1 to about 3.96/1; MXDyTZ, wherein x is about 0.01 to about 3,900,000, y is about 0.035 to about 10,000,000, z is about 0.35 to about 8,000,000; TD, wherein the ratio of T to D is about 0.001/1 to about 73/1; or a combination comprising at least one of the foregoing resins, wherein the resin or resin combination is present in an amount effective to increase the SPF of the formulation at least about 10% over the same formulation without the resin or resin combination. The silicone resins are easily formulated, provide a unique non-tacky sensory experience and exhibit advantageous spreadability while permitting th...
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CLEANSING FOAMING SUNSCREEN LOTION

(WO2006110555) 19.10.2006 A61K 9/00 COTY S.A.S.
The invention described herein includes a sunscreen formulation comprising: a sunscreen, a structurant and an emulsion comprising a homogenized mixture of wax and alcohol components, at least one of which is a surfactant, wherein the formulation comprises a stable lamellar or spherulite phase.
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PHOTOABSORBING, HIGHLY CONJUGATED COMPOUNDS OF CYANOACRYLIC ESTERS, SUNSCREEN COMPOSITIONS AND METHODS OF USE

(WO2006110301) 19.10.2006 C07C 255/41 CPH INNOVATIONS CORP.
Novel derivatives of a-cyano--naphthyl acrylates, sunscreen compositions including one or more a-cyano--naphthyl acrylate derivatives are described herein. Also disclosed are methods for stabilizing a sunscreen composition and methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing a-cyano-- naphthyl acrylate derivatives.
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RAZOR HEAD WITH MILD CLEANSING COMPOSITION AS A SHAVING AID

(WO2006108522) 19.10.2006 A61Q 9/02 UNILEVER PLC
A razor head assembly is described that contains a mild cleansing composition (14, 54) including acyl isethionate surf astant (s) positioned adjacent to a blade (18, 58, 118,158) for shaving and treating the skin. The isethionate surfactants provide the user with nearly simultaneous moisturization, cleansing and shaving. An after shave phase (70) is provided in addition to the cleansing phase in a preferred embodiment .
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COMPOSITION COMPRISING METAL OXIDES

(WO2006108132) 12.10.2006 A61K 8/29 THE PROCTER &GAMBLE COMPANY
A composition is provided comprising: (a) first metal oxide particles having a first number weighted average primary particle size from 1nm to 50nm; and (b) second metal oxide particles having a second number weighted average primary particle size which is greater than 50nm and less than or equal to 200nm; wherein organo-functionalised silicone fibrils are bonded to and extend away from the surface of one or both of the first and second metal oxide particles.
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TRANSLUCENT, SUNSCREENING COSMETIC FOUNDATION COMPOSITION

(WO2006108003) 12.10.2006 A61K 8/29 THE PROCTER &GAMBLE COMPANY
A cosmetic foundation composition is provided having an SPF value of greater than or equal to 15, preferably greater than or equal to 18, more preferably greater than or equal to 20 and a ?LT value greater than or equal to 0.5, preferably greater than or equal to 1.0, more preferably greater than or equal to 2.5, where ?LT is measured according to the following equation: ?LT = ?L2- ?L1Where: AL1 = L1110-L115; ?L2 = L2110 - L215 L1 is a measurement of Ly taken on bare skin, to which no product has been applied; L2 is a measurement of Ly taken on skin, to which product has been applied; and Ly is the translucency value at a specific angle, y, from specular.
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SKIN ENRICHMENT USING COQ10 AS THE DELIVERY SYSTEM

(WO2006107825) 12.10.2006 A61K 31/7048 ZYMES, LLC
The present invention provides several skin enrichment formulations comprising ubiquinones. The present invention provides a composition for the treatment of acne, topical antimicrobial ointment, sunscreening agents, facial cleansing, reduction of skin inflammation, firming skin tone, cosmetic foundation, skin protection, lip skin protection and skin cream. In a preferred embodiment, the composition contains Coenzyme Q10.
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A NON-RINSE-OFF COSMETIC COMPOSITION AND A COSMETIC PRODUCT COMPRISING SAID COMPOSITION

(WO2006105628) 12.10.2006 A61Q 1/06 NATURA COSMTICOS S.A.
The present invention relates to a non-rinse-off cosmetic composition that provides to the skin, especially the lip skin, a hydrating and restoring action. More specifically, the invention relates to a non-rinse-off cosmetic composition particularly usable on the skin in the region of the lips, which comprises ricinoleyl monomaleate triglyceride and palmitic acid. Further, the present invention relates to cosmetic products comprising the cosmetic composition described above.
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PERSONAL CARE COMPOSITIONS WITH COLOR CHANGING INDICATOR

(WO2006105193) 05.10.2006 A61Q 19/10 C2C TECHNOLOGIES LLC
The invention describes a composition for use in disinfecting a surface for personal use, such as a public restroom facility or telephone. The composition and delivery of the composition provides for the placement of a thin layer of disinfectant which includes a acid-base indicator. The acid-base indicator disappears as the thin layer effects the germicidal activity of the disinfectant. The composition is also rapidly drying, so that the acid-base indicator disappears as well as the disinfecting composition leaving the surface dry. The invention also relates to use of the compositions in a lotion, such as a sunscreen. Use of the acid-base indicator provides a method to visualize where the lotion is applied by color, with the color then late...
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APPARATUS AND METHOD OF APPLYING SUNSCREEN OR SIMILAR LIQUID

(WO2006104705) 05.10.2006 B05B 15/12 LOTTERHOS, William, Christopher
A booth with a plurality of spray nozzles for the application of sunscreen, insect repellent, aloe lotion, skin care products, or similar lotions or liquids to substantial portions of the human body. One or more spray nozzles are oriented to avoid opposing air or spray flows that may cause inefficient or uneven application of the lotion or liquid. Spray nozzles may be fixed or adjustable. The invention may include means for rinsing the body prior to application of the lotion or liquid to promote even and unobstructed application to the body, as well as means for washing down the booth between or after use is provided. Power may be provided by electrical power sources, a battery, or solar panel(s).
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COMPOSITION COMPRISING N-PROPANOYL DERIVATIVES OF AMINO ACIDS, AMINOCARBOHYDRATES AND DERIVATIVES THEREOF

(WO2006101940) 28.09.2006 A61K 31/4172 YU, Ruey, J.
The embodiments relate to compositions comprising therapeutically effective amounts of at least one N-propanoyl derivative of amino acids, aminocarbohydrates, and derivatives thereof. The compositions are useful the prevention and treatment of symptoms or syndromes associated with nervous, vascular, musculoskeletal, or cutaneous systems. The compositions may be topically or systemically administered to a subject in need thereof.
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METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING AGING OR PHOTODAMAGED SKIN

(WO2006101855) 28.09.2006 A61Q 19/08 PROCYTE CORPORATION
Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.
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BENZOIC ACID ESTER COMPOUNDS, COMPOSITIONS, USES AND METHODS RELATED THERETO

(WO2006100225) 28.09.2006 C07C 219/34 FERRER INTERNACIONAL, S. A.
Benzoic acid ester compounds of formula (I) wherein R and R1-R5 have the meanings explained in the description, methods for producing them and use thereof in cosmetic, pharmaceutical, personal care and industrial preparations as sunscreens based on photochemical precursor properties of ultraviolet absorbers.
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SUNSCREEN AEROSOL SPRAY

(WO2006099687) 28.09.2006 A61P 17/16 ENSIGN LABORATORIES PTY LTD
A sunscreen formulation and a method of dispensing the sunscreen formulation is described in which the sunscreen formulation in the form of an emulsion includes one or more sunscreen agents and one or more propellants contained within an aerosol can such that the sunscreen composition is dispensed from the aerosol can by the propellant(s) in the form of a fine mist spray or fog allowing a uniform film of the sunscreen composition to be applied to the skin of a person to provide a uniform form of protection so as to overcome the harmful effects of the suns rays on the skin.
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NOVEL RESORCINOL DERIVATIVES FOR SKIN

(WO2006097224) 21.09.2006 A61Q 19/02 UNILEVER PLC
New 4-substituted resorcinol derivatives of general formula (I) and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: formula (I) and formula (B) wherein, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, or acyl groups. Preferably, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl or acyl groups. R1 represents hydrogen (H); linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R1 represents hydrogen (H) or a C1 alkyl group (i.e, methyl group). More preferably, R1 represents hydrogen. n rep...
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NOVEL RESORCINOL DERIVATIVES

(WO2006097223) 21.09.2006 A61K 8/34 UNILEVER PLC
New 4-substituted resorcinol derivatives of general formula (I) and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening and/or reducing the appearance of oily or greasy skin: wherein, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, or acyl groups; preferably X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl or acyl groups; R1 and/or R2 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group; n represents 0, 1; and when n = 0, the ring is a cyclopentyl with or without one heteroatom...
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LONG LASTING WATERPROOF SUNSCREEN COMPRISING METAL OXIDE AND PEPTIDE CONDITIONER

(WO2006094095) 08.09.2006 A61K 8/19 E.I. DUPONT DE NEMOURS AND COMPANY
The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen agent, such as titanium dioxide nanoparticles, and a fluid vehicle.
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NATURAL SUNLIGHT PHOTOSTABLE COMPOSITION

(WO2006086354) 17.08.2006 A61K 8/00 TANNING RESEARCH LABORATORIES, INC.
The present invention relates to photostable compositions that provide protection from ultraviolet radiation ('UVR'). The invention particularly relates to the sunscreens avobenzbne, octocrylene and oxybenzone, forming a triplet combination. Compositions of the present invention are free of diesters or polyesters of naphthalene dicarboxylic acid and also are substantially free of substantial amounts of other sunscreens and substantial amounts of optimizing agents. Sunscreens of the invention may be essentially free of, or free of, lower monohydric alcohol and/or acrylates/C12-22 alkylmethacrylate copolymer in an effective non-pilling amount used to gel a C1-C4 alcohol. The triplet combination surprisingly provides and substantially maintain...
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METHOD OF PROMOTING HAIR GROWTH

(WO2006084312) 17.08.2006 A61K 31/568 ACRUX DDS PTY LTD
This invention relates to method of promoting hair growth comprising topically applying to the area of skin in which loss is to be treated or prevented a composition comprising an androgen selected from the group consisting of testosterone and pharmaceutically acceptable esters thereof and a carrier comprising a volatile solvent. The invention also relates to a topical composition for promoting hair growth.
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IMPROVED BIOAVAILABILITY AND IMPROVED DELIVERY OF ALKALINE PHARMACEUTICAL DRUGS

(WO2006084174) 10.08.2006 A01N 43/90 YU, Ruey, J.
Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.
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PERSONAL CARE COMPOSITION CONTAINING HYDROPHOBICALLY MODIFIED POLYMERS

(WO2006081496) 03.08.2006 A61K 8/02 NALCO COMPANY
A cosmetically acceptable composition comprising one or more hydrophobically modified polyacrylamides prepared by incorporating hydrophobic moieties into a polymer composed acrylamide, one or more cationic monomers and optionally one or more anionic monomers. The composition may be incorporated into products for treating hair, skin and nails and also into household products such as household cleaners and laundry detergents.
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METHOD AND APPARATUS FOR HIGH RESOLUTION SPATIALLY MODULATED FLUORSCENCE IMAGING AND TOMOGRAPHY

(WO2006078973) 27.07.2006 G01N 21/55 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
An improvement in a method for quantitative modulated imaging to perform depth sectioned reflectance or transmission imaging in a turbid medium, such as human or animal tissue is directed to the steps of encoding periodic pattern of illumination preferably with a fluorescent excitation wavelength when exposing a turbid medium to the periodic pattern to provide depth-resolved discrimination of structures within the turbid medium; and reconstructing a non-contact three dimensional image of the structure within a turbid medium. As a result, wide field imaging, separation of the average background optical properties from the heterogeneity components from a single image, separation of superficial features from deep features based on selection of...
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COMPOSITION AND METHOD FOR TREATING HYPERPIGMENTED SKIN

(WO2006078399) 27.07.2006 A61K 8/36 LIPO CHEMICALS, INC.
The composition comprises a hydroxycinnamic acid or a methoxycinnamic acid dissolved in a compound having one or more hydroxy groups, like a mono Cl -4 alkyl ether of an ethylene glxcol or a mono Cl -4 alkyl ether of a propylene glycol oligomer, and/or a silicone fluid.
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PERSONAL CARE COMPOSITIONS

(WO2006076065) 20.07.2006 A61K 9/10 DOW GLOBAL TECHNOLOGIES INC.
The deposition of a benefit agent on a substrate after treatment of the substrate with a personal care composition which has a viscosity of at least 50 mPa.s at 25 C and comprises the benefit agent and a low molecular weight surfactant is improved when a water-soluble polymer is used as a substitute for at least a portion of the low molecular weight surfactant. The headspace concentration of a fragrance provided by such personal care composition is also increased.
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ALCOHOL-FREE MICROEMULSION COMPOSITION

(WO2006074177) 13.07.2006 A61K 8/00 MARY KAY INC.
The present invention concerns compositions that comprise alcohol-free microemulsions and methods for their use that include a surfactant, a lipophilic linker, and/or a hydrophilic linker. These compositions can be used, for example, in cosmetic or hair applications, hi certain aspects, compositions of the invention have the ability to rnicroemulsify sebum while providing enhanced cleansing of cosmetic products from the skin or hair, hi addition, the compositions have the ability to enhance the penetration of skin or hair active ingredients, such as emollients, humectants, anti-oxidants, lipids, vitamins, botanicals, dyes, tanning compounds, etc.
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COMPOSITIONS COMPRISING O-ACETYLSALICYL DERIVATIVES OF AMINOCARBOHYDRATES AND AMINO ACIDS

(WO2006074114) 13.07.2006 A01N 61/00 YU, Ruey, J.
The embodiments described herein include a composition and method of treatment using compositions that include at least one 0-acetylsalicyl derivative. The compositions and methods are useful in preventing and treating disorders and syndromes associated with anyone of the nervous, vascular, musculoskeletal, or cutaneous systems.
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SKIN CARE COMPOSITIONS

(WO2006072175) 13.07.2006 A61Q 17/04 HABER DERMACEUTICS INC.
A skin care composition is provided which preferably comprises a mixture of N-acetylcysteine and L-carnosine in combination with a cosmetic, dermatological or pharmaceutically acceptable carrier therefor. The composition may optionally be provided as a sunscreen formulation, and provides a method for the prevention, amelioration or treatment of pathological conditions of the skin, including, but not limited to, intrinsic or chronological aging, or aging due to sun damage (photoaging), and which conditions are caused by, or exacerbated by, oxidative stress, carbonyl stress, or a combination of both.
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METHOD FOR EXTENDING LIFESPAN AND DELAYING THE ONSET OF AGE-RELATED DISEASE

(WO2006066244) 22.06.2006 A61K 31/19 CASH, Alan, B.
A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is ...
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ANTI-AGING METHODS AND COMPOSITION

(WO2006065920) 22.06.2006 A61K 8/02 AQUAPHOTONICS, INC.
An anti-aging method and composition are disclosed. The composition is a micro-cluster water having anti-oxidant and free-radical quenching properties. The method involves contacting a cell or portion thereof in danger of free-radical or oxidant damage with the micro-water.
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PEST CONTROL COMPOSITIONS, AND METHODS AND PRODUCTS UTILIZING SAME

(WO2006065886) 22.06.2006 A01N 37/02 HOMS, LLC
Pest-combating compositions containing modified volatility pest-control actives are formulated for sustained test-combating efficacy, utilizing oleochemicals subjected to transesterification, methanolysis or conversion of fatty acids to alkyl esters as modified volatility components. In a specific formulation, the pest-combating composition includes soy methyl ester and 2-undecanone. The composition may be constituted as a spray composition, lotion, paste, or other compositional form. Pests that may be usefully combated with such composition include mosquitoes, ticks, cockroaches, thrips, flies, gnats, beetles and aphids.
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PERSONAL CARE AND HOUSEHOLD COMPOSITIONS OF HYDROPHOBICALLY-MODIFIED POLYSACCHARIDES

(WO2006065848) 22.06.2006 A61K 8/73 HERCULES INCORPORATED
A conditioning composition is used in functional systems (personal care and household care compositions) that has a nonionic hydrophobically modified cellulose ether (HMCE) having a weight average molecular weight (Mw) with a lower limit of 400,000 and an upper limit of 2,000,000 and a hydrophobic substitution lower limit of 0.6 wt % and an upper limit amount which renders said cellulose ether insoluble in a 5 wt % solution of surfactant and less than 0.05 % by weight soluble in water and wherein the cellulose ether provides conditioning benefit to the functional system substrate.. This composition has at least one active functional system ingredient.
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ANTIAGING COMPOSITION

(WO2006061627) 15.06.2006 A61K 8/27 OXONICA LTD
A composition suitable for cosmetic or topical pharmaceutical use which comprises: (1) an antiaging agent; and (2) an amount of a metal oxide that is capable of scavenging free radicals and /or a metal oxide which has been doped with one or more other elements and/or reduced zinc oxide; the antiaging agent comprising at least one component which is photosensitive and/or which is susceptible to free radical attack and/or in which degradation is induced by another ingredient of the composition, for example one or more cytokinins and/or one or more extracts from Boswellia Serrata.
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NOVEL SKIN CARE FORMULATION

(WO2006057756) 01.06.2006 None COLGATE-PALMOLIVE COMPANY
Skin moisturizing formulations which can be administered in the bath or shower, depositing a thin layer of moisturizing agents on application, which is not rinsed off but remains to protect the skin from drying, resulting in smoother, softer skin feel; the formulations comprising polyvalent metal cations and fatty acids, which react on application in the shower or bath to form a thin deposit of insoluble salts, thereby enhancing the retention of moisturizing oils and conditioning agents.
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COSMETIC COMPOSITIONS CONTAINING SOPHORA ALOPECUROIDES L.EXTRACTS

(WO2006056317) 01.06.2006 A61K 8/97 UNILEVER PLC
Disclosed are extracts of Sophora alopecuroides L. as cosmetic skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. Also disclosed are active ingredients in the extracts, including alopecurone A, alopecurone B, sophoraflavone-G, sophoraflavone-I, sophoraflavone-K, and mixtures thereof. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin and are available in nature.
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FOAMABLE ALCOHOL

(WO2006055017) 26.05.2006 C11D 1/02 NOVAK, John, T
The present invention is a foamed alcohol. Alcohol, such as ethyl alcohol is combined with a fluoro-surfactant and water. Optionally, additional ingredients such as fragrance, color, moisturizers, conditioners, sunscreen, etc. can be added. The fluoro-surfactant reduces the surface tension of the alcohol allowing it to be foamed without reducing the effectiveness of the alcohol in sterilizing and sanitizing. The invention mixture foams when dispensed as an aerosol or pumped through a foam pump. The foam is easy to apply, and liquefies as a user smears it on his or her hands or other surface. In an alternative embodiment the foamable alcohol has at least one active ingredient. The active ingredient can be a prescription or non-prescription d...
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PHARMACEUTICAL COMPOSITION COMPRISING A MACROLIDE T-CELL IMMUNOMODULATOR AND ANTI-PHOTOAGING AGENT

(WO2006053699) 26.05.2006 A61P 17/00 NOVARTIS AG
Compositions are provided comprising a macrolide T-cell immunomodulator or immunosuppressant agent, e.g. pimecrolimus, and at least one anti-photoaging agent such as a sunscreen, an anti-oxidant or a DNA-repair enzyme. They are useful in particular in the curative treatment or prevention of dermatological diseases and of conditions where it is desired to inhibit the skin aging effects of light radiation such as UV-A and UV-B light, e.g. development of skin cancer.
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ADDITIVE FOR UV-SUNSCREEN PREPARATIONS

(WO2006048159) 11.05.2006 C08F 2/22 DSM IP ASSETS B.V.
The invention relates to the use of polymeric particles for boosting the UV absorption of an UV filter in an UV-sunscreen composition, wherein the polymeric particles comprise at least one polymeric particle comprising at least one chromophore having an UV absorption maximum at ?max = 275 nm covalently bound thereto.
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PERSONAL CARE COMPOSITIONS WITH GLYCERIN AND HYDROXYPROPYL QUATERNARY AMMONIUM SALTS

(WO2006045584) 04.05.2006 A61Q 15/00 UNILEVER PLC
A personal care composition is provided formulated with glycerin and a moisturization enhancing agent which is a salt of structure AB, wherein A is a cationic charged component, B is an anionic charged component, and A has at least one quaternized nitrogen atom and at least two hydroxyl groups and a molecular weight no higher than 400.
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PERSONAL CARE COMPOSITIONS WITH SILICONES AND DIHYDROXYPROPYL TRIALKYL AMMONIUM SALTS

(WO2006045583) 04.05.2006 A61Q 19/00 UNILEVER PLC
A personal care composition is provided with a silicone compound and being aesthetically modified for improved skinfeel with a quaternary ammonium salt, the salt having a structure AB, wherein A is a cationic charged component, B is an anionic charged component, and A has one quaternized nitrogen atom, at least two hydroxyl groups and a molecular weight no higher than 250.
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QUATERNARY AMMONIUM SALTS AS ANTI-AGING ACTIVES IN PERSONAL CARE COMPOSITIONS

(WO2006045471) 04.05.2006 A61K 8/41 UNILEVER PLC
A personal care product is provided which includes a package filled with a personal care composition and instructions printed on or associated with the package indicating topical use of the composition on skin for purposes of controlling the signs of aging. The composition includes a quaternary ammonium compound selected from (a) salts of hydroxypropyltri(C1 -C3 alkyl)ammonium mono-substituted monosaccharide; (b) salts of hydroxypropyltri(C1- C3 alkyl)ammonium mono-substituted polyols, the salts having a cation of an average molecular weight no higher than 450 and the salt having a Tg no higher than 10C; (c) dihydroxypropyltri(C1-C3alkyl)ammonium salts; (d) chlorohydroxypropyltri(C1 -C3alkyl)ammonium salts; and (e) mixtures thereof.
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PERSONAL CARE COMPOSITIONS WITH SALTS OF HYDROXYPROPYL TRIALKYLAMMONIUM SUBSTITUTED MONO-SACCHARIDE

(WO2006045428) 04.05.2006 A61K 8/60 UNILEVER PLC
A personal care composition is provided which includes a quaternary ammonium compound which is a salt of hydroxypropyl tri(C1-C3 alkyl)ammonium mono-substituted monosaccharide. Particularly preferred are hydroxypropyl trimonium quaternized glucose or fructose. These quaternary ammonium salts provide moisturization properties to the personal care composition both in high and low relative humidity environments.
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PERSONAL CARE PRODUCTS WHICH INCLUDE DIHYDROXYPROPYLTRI (C1-C3 ALKYL) AMMONIUM SALTS

(WO2006045427) 04.05.2006 A61Q 5/02 UNILEVER PLC
A personal care product is provided which includes a composition containing dihydroxypropyltri(C1-C3 alkyl) ammonium salt in a carrier. The composition is packaged for delivery to a consumer and includes instructions printed on or associated with the packaging indicating topical use of the composition on skin, hair or the oral mucosae. Particularly useful is dihydroxypropyltrimonium chloride. The salt operates as a humectant to moisturize both at high and low relative humidity environments.
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PERSONAL CARE COMPOSITION CONTAINING OZONE-STRESSED YEAST LYSATES

(WO2006044482) 27.04.2006 G11B 7/00 ARCH PERSONAL CARE PRODUCTS, L.P.
The present invention relates to an ozone-stressed yeast lysate, and a personal care composition including an ozone-stressed yeast lysate and at least one preservative selected from the group consisting of alcohols, glycols, parabens, hydantoins, quaternary nitrogen-containing compounds, isothiazolinones, aldehyde-releasing agents, and halogenated compounds. The present invention also relates to a method for preparing and using the ozone-stressed yeast lysate and the personal care composition. (Drawing Figure 1)
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TOPICAL SKIN LIGHTENING CREAM

(WO2006043940) 27.04.2006 A61K 33/04 VU HUYNH, Anthony
The present invention is a novel topical composition for the treatment of non-congenital dermal blemishes comprising, hydroquinone wherein the concentration of hydroquinone is not less than 2 percent and not more than 12 percent, tretinoin wherein the concentration of tretinoin is not less than 0.01 percent and not more than 0.01 percent, a steroid wherein the steroid is selected from class 5, 6, or 7 steroids; and sunscreen having a sun protection factor of not less than 15 and not more than 50.
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SURFACTANT COMPOUNDS

(WO2006043048) 27.04.2006 C11D 3/37 CRODA INTERNATIONAL PLC
Fatty esters of oligoesters of a dicarboxylic acid and a polyol retaining at least one free hydroxyl group, particularly of the formula (I): R1-[OR2O-C (O)-R3-(O)C-]m-R4 (I), where R1 is H, a monocarboxylic acid group, or R6O-[C(O)-R3-(O)C]-; R2s are residues of polyols having at least one substituent free hydroxyl; R3s are hydrocarbylene; R4 is -OH, -OM where M is a salt forming metal, amine or ammonium, -OR6, or -OR2O-R7; R5 is C7 to C21 hydrocarbyl; R6 is C8 to C22 hydrocarbyl; R7 is H, or -C(O)R5; and m is 1 to 20; provided that at least one of R1 and R4 is or includes a C8 to C22 group, are surfactants. A range of surfactant properties can be obtained by varying the molecules within these ranges. Especially where R2 is derived from a h...
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DEPOSITABLE SOLIDS

(WO2006042176) 20.04.2006 A61K 8/03 THE PROCTER &GAMBLE COMPANY
The present invention is a stable, rinsable multi-phase personal care composition comprising: at least two visually distinct phases; wherein at least one visually distinct phase comprises from about 1 % to about 99 % of a depositable solid by weight of the composition; and wherein said stable multi-phase personal care composition provides at least about 0.2 % Depositable Solids.
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CONVERSION OF LIQUID COMPOSITIONS TO A POWDER

(WO2006041782) 20.04.2006 A61K 8/02 AMCOL INTERNATIONAL CORPORATION
A powdered composition comprising a liquid or semisolid formulation and a polymeric microparticle delivery system. The powdered composition is capable of converting to the liquid or semisolid composition upon application to a substrate, such as skin or a scalp.
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COMPOSITION OF SUNSCREEN AND COLOR-CHANGING MARKERS

(WO2006039515) 13.04.2006 A61K 8/49 SCHAFFER, Robin
A sunscreen/sunblock product that combines sun protection and color marking activities intended to encourage use of sunscreen, especially among young children. The sunscreen/sunblock product also enables a user to visualize when the product needs to be re-applied. The sunscreen composition incorporates a color-triggerin;, developer into commercially available sunscreens. This sunscreen product may b-used as a regular colorless or colored sunscreen. A marking composition containi g a color precursor is also prepared. A marking device may be utilized to store and/o apply the marking composition to the skin which is covered with a thin layer of th- sunscreen product. Color markings are formed through the reaction of the color-tri-g...
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A MULTI-COMPONENT CONTROLLED DELIVERY SYSTEM FOR SOAP BARS

(WO2006036617) 06.04.2006 A61K 8/36 SALVONA LLC
The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The high cationic charge density on the nanosphere surface is create...
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DELIVERY SYSTEM FOR TOPICALLY APPLIED COMPOUNDS

(WO2006036557) 06.04.2006 A61K 47/12 LIPO CHEMICALS, INC.
A delivery system for topically applied compounds is disclosed. The delivery system contains a fatty acid, a phospholipid, and an oil, and is activated by the addition of water. The delivery system is admixed with a topically applied compound and water to provide a composition suitable for application to the skin or hair. The relative amounts of delivery system ingredients provide round, flexible vesicles that allow penetration of the topically applied compound to the epidermis and dermis, vesicles having a partially ruptured membrane for a controlled delivery of the topically applied drug to the epidermis and dermis, completely ruptured vesicles in the form of lamellar sheets that allow the topically applied compound to be retained in the ...
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HIGH DS CATIONIC POLYGALACTOMANNAN FOR SKINCARE PRODUCTS

(WO2006036510) 06.04.2006 A61K 8/73 HERCULES INCORPORATED
A skin care composition is provided with a) from about 1 to about 90 wt % of a surfactant, b) at least about 0.05 wt % of a cationic polymer wherein the cationic polymer has a mean average molecular weight (Mw) from about 2,000 to about 10,000,000 Dalton, and the cationic polymer has a cationic degree of substitution (DS) greater than 0.25 to about 3.0, and c) at least one skin care active ingredient, wherein the skin care composition provides at least one of the functions of cleansing, protection, moisturizing, firming, conditioning, occlusive barrier, emolliency, depositing, and anti-wrinkling to the skin.
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PERSONAL CARE PRODUCTS INCORPORATING CELLULOSIC FATTY ACID ESTERS

(WO2006034071) 30.03.2006 A61K 8/73 EASTMAN CHEMICAL COMPANY
A personal care product composition containing a long chain fatty acid cellulose ester (LCCE) having a degree of substitution greater than about 1.0 of an ester substituent or residue from fatty acids having from 6 to 18 carbon atoms wherein the LCCE is soluble in at least one cosmetically acceptable solvent selected from the group consisting of hydrocarbons, alkyl esters, fats and oils, fatty acids, fatty alcohols, and silicone oils.
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AN ANTIOXIDANT COMPLEX AND A COSMETIC AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPLEX

(WO2006032122) 30.03.2006 A61K 8/67 NATURA COSMTICOS S.A.
The present invention relates to an antioxidant complex compri-sing from 0.000001 /a to 40.00000% by weight of at lest one cinnamiA acid, from 0.000001 % to 40.00000% by weight of at least one carotenoid, from 0.000001 % to 99.999998% by weight of vitamin E, and a cosmetically and pharmaceutically acceptable a carrier, all the amounts being based on the total weight of the antioxidant complex. The present invention further relates to cosmetic and pharma-ceutical compositions comprising said antioxidant complex. The antioxidant complex of the present invention, as well as the above-cited compositions, aid in protecting and preventing cellular and cuta-neous damages resulting from the action of free radicals.
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POSS CONTAINING COSMETIC COMPOSITIONS HAVING IMPROVED WEAR AND/OR PLIABILITY AND METHODS OF MAKING IMPROVED COSMETIC COMPOSITIONS

(WO2006031781) 23.03.2006 C08L 83/04 L'OREAL
Film-forming and cosmetic compositions containing a combination of certain polyhedral oligomeric silsesquioxanes (POSS) and non-POSS silicone resins are described, the combination providing improved wear and/or pliability properties over previous silicone resin containing compositions. Typically, the advantageous combinations will be formulated in a cosmetic composition that contains at least one solvent, and, preferably, a colorant, such as a pigment. Other cosmetic ingredients known to those of skill in the art can also be combined therewith, depending on the desired product, such as a foundation, mascara, lip coating (lip stick, lip gloss, lip pencil and the like), nail coating and the like. Methods of making cosmetic compositions includ...
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FUNCTIONAL SYSTEMS WITH REDUCED ODOR CATIONIC POLYGALACTOMANNAN

(WO2006026750) 09.03.2006 C08B 37/00 HERCULES INCORPORATED
A reduced odor composition is composed of a functional system such as household care, personal care or pet care products and at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a cationic degree of substitution (DS) lower limit of about 0.01 and an upper limit of about 3.0 and weight average molecular weight (Mw) having a lower limit of 200,000 and an upper limit of 2,000,000 a concentration with a lower limit of 0.005 wt % and an upper limit of 10 wt %, and a trimethylamine content of less than 25 ppm, wherein the composition, at an alkaline pH, has no discernible amine odor.
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IMPROVED TOPICAL SKIN CARE COMPOSITIONS

(WO2006026168) 09.03.2006 A61K 8/893 AVON PRODUCTS, INC.
A novel combination of silicon resin, amorphous silica and low oil absorbing spherical powder is described which when added to topical skin care compositions containing high concentrations of active agents, improves their aesthetic feel and ease of application.
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REDUCED ODOR IN LOW MOLECULAR WEIGHT CATIONIC POLYGALACTOMANNAN

(WO2006026113) 09.03.2006 C08B 37/00 HERCULES INCORPORATED
A reduced odor composition is composed of at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a weight average molecular weight (Mw) having a lower limit of 5,000 and an upper limit of 200,000, a light transmittance in a 10 % aqueous solution of greater than 80 % at a light wavelength of 600 nm, a protein content of less than 1.0 % by weight of polysaccharide, and a trimethylamine content of less than 25 ppm in a 10 % aqueous solution of the polymer. This composition is prepared by treating the polymer with reagents that reduce the molecular weight of the polymer, removing the water-insoluble solid material, and removing odorous components, including trimethylamine (TMA) and other amines and low mole...
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SILICONE EMULSIONS AND THEIR PREPARATION

(WO2006020233) 23.02.2006 C08J 3/03 DOW CORNING CORPORATION
Multiple emulsions of the water-in-oil-in-water (W/O/W) type and processes for their preparation are disclosed. The multiple emulsions contain an oil phase comprising a mixture of: (i) a polysiloxane (S) which is a chain extension reaction product of a polysiloxane (S1) having reactive end groups, and (ii) a hydrophobic material (H) which is miscible with polysiloxane (S1) and with polysiloxane (S). The multiple emulsions allows for the entrapment and controlled delivery and release of water-soluble active ingredients.
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NATURAL SUNLIGHT PHOTOSTABLE COMPOSITION

(WO2006016975) 16.02.2006 A61K 8/00 TANNING RESEARCH LABORATORIES, INC.
The present invention relates to photostable compositions that provide protection from ultraviolet radiation ('UVR'). The invention particularly relates to the sunscreens avobenzone, octocrylene and oxybenzone, forming a triplet sunscreen combination. Compositions of the present invention are generally substantially free of substantial amounts of other sunscreens. The triplet combination surprisingly provides and substantially maintains the initial SPF value of the sunscreen composition throughout the period of UVR exposure. Compositions of the invention are photostable such that each of sunscreen active in the triplet combination does not appreciably photodegrade. The present invention accurately communicates the amount of UVR photoprotect...
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AMINOBUTADIENE-BASED UV SCREENS

(WO2006016806) 16.02.2006 A61K 8/42 FUJIFILM MANUFACTURING EUROPE B.V.
The invention relates to the use of an UV-absorbing compound for the preparation of a cosmetic composition for protection against UV radiation said compound being represented by the general formula (I) wherein less than 10 % of the total absorption between 250 and 600 nm of said UV-absorbing compound according to formula (I) is above 400 nm. The invention also relates to sunscreen compositions comprising the UV-absorbing compound according to formula (I).
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PARTUCULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS

(WO2006014626) 09.02.2006 A61K 31/74 CELATOR PHARMACEUTICALS, INC.
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.
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HAIR AND SKIN CARE COMPOSITION

(WO2006014216) 09.02.2006 A61K 8/81 AVON PRODUCTS, INC.
The present invention provides cosmetic compositions that form a durable film or coating on surfaces such as hair or skin. The compositions of the invention comprise one or more anionic silicones and one or more high molecular weight esters, the combination of which provides a durable film. Methods for treatment of hair and skin employing the compositions of the invention are also provided.
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SKIN COATING COMPOSITION AND USES THEREOF

(WO2006010222) 02.02.2006 A61Q 1/02 BLONDE HOLDINGS PTY LTD.
The present invention relates to a composition for coating the skin wherein the composition forms a waterproof flexible film on the skin. Preferably, the flexible film is durable and is capable of remaining adhered to the skin for 1 to 3 days. The composition may include (i) one or more pigments and/or dyes, or (ii) one or more sunscreen agents or (iii) one or more therapeutic agents for preventing or treating disorders of the skin. The coating composition comprises resin and flexibilizer (platicizer). Any suitable type of natural or synthetic resin may be used, preferably the resin is shellac or other natural gum derivative. A suitable flexiblizer is an animal, vegetable, mineral or synthetic oil, preferably castor oil, pine oil, rosehip o...
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NATURAL SUNSCREEN COMPOSITION

(WO2006010214) 02.02.2006 A61Q 17/04 CREAM HOLDINGS PTY LTD
A natural sunscreen composition comprising synergistically effective amounts of zinc oxide and a plant-derived oil. The composition allows for the provision of a natural sunscreen which is water resistant and has a high SPF rating. A method and process are also described.
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DENDRIMER-AMINOBUTADIENE-BASED UV-SCREENS

(WO2006009451) 26.01.2006 C08L 101/00 FUJI PHOTO FILM B.V.
The invention relates to UV-absorbing polymers, said UV-absorbing polymer comprising a synthetic amine rich polymer to which is covalently linked to an aminobutadiene represented y the general formula (I) wherein the UV-absorbing polymer has a number average molecular weight Mn of 1000 g/mol to 100.000 g/mol; and said UV-absorbing polymer having a UV-absorption of at least 5.6 a.u./g.L at 375 nm.
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LIGHT PROTECTING-EFFECTIVE COSMETIC OR DERMATOLOGICAL PREPARATIONS

(WO2006008252) 26.01.2006 A61K 8/02 CIBA SPECIALTY CHEMICALS HOLDING INC.
Disclosed is the use of an insoluble or sparingly soluble micronized substance class which is not a cosmetic UV absorber and which is dispersed in the oil- or water-phase of a cosmetic or dermatological composition for the enhancement of light protecting action of this cosmetic or dermatological composition comprising at least one cosmetic UV filter which is soluble in the water- or oil-phase. The cosmetic preparation according to the invention shows a remarkable increase in SPF.
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METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING HYPERPIGMENTATION OF SKIN

(WO2006004787) 12.01.2006 A61K 8/19 PROCYTE CORPORATION
Disclosed are methods for treating hyperpigmentation of skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.
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TOPICAL COMPOSITIONS FOR ANTI-AGING

(WO2006004759) 12.01.2006 A61K 31/565 MCCLELLAN, Stephanie, N.
A pharmaceutical composition for treatment of skin aging including a pharmaceutically effective amount of estriol; a pharmaceutically effective amount of estradiol; a pharmaceutically effective amount of hyaluronic acid; a pharmaceutically effective amount of green tea extract; and a pharmaceutically acceptable carrier is provided. In some embodiments, the composition further includes ascorbic acid, date palm extract, or a combination thereof. Also disclosed is a method for treating symptoms of skin aging and photoaging by administering a pharmaceutical composition having estriol, estradiol, hyaluronic acid, green tea extract, a pharmaceutically acceptable carrier and optionally, ascorbic acid and date palm extract. A method of promoting ur...
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COSMETIC COMPOSITIONS AND METHODS COMPRISING RHODIOLA ROSEA

(WO2006004695) 12.01.2006 A61K 36/73 E-L MANAGEMENT CORP.
A cosmetic composition comprising a UV-protective amount of at least one rosavin, preferably present in an extract of Rhodiola rosea in a cosmetically acceptable vehicle, and methods of use thereof, including preventing or reducing the signs of photoaging.
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BLEACHING COMPOSITION

(WO2006002777) 12.01.2006 C11D 3/00 UNILEVER PLC
Bleaching composition is provided which comprises vitamin K3 and an antioxidant.
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CARE COMPOSITION

(WO2006002714) 12.01.2006 C09J 7/02 UNILEVER PLC
A method is provided for preserving the integrity of stretchy polymer fibres.
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COSMETIC COMPOSITIONS CONTAINING FULLERENE CLUSTERS

(WO2006001784) 05.01.2006 A61K 7/043 BURANGULOV, Nail
The present invention is directed to a cosmetic composition comprising effective amounts of fullerene clusters in association with cosmetically acceptable carrier to prevent or retard fee radical oxidation processes in the skin and to the methods of using said composition for reducing damage to healthy skin or mucous membranes by free radicals
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HYDROPHOBIC OPHTHALMIC COMPOSITIONS AND METHODS OF USE

(WO2005123035) 29.12.2005 A61K 9/00 OCULARIS PHARMA, INC.
The present invention is an eye preparation comprising a hydrophobic composition adapted for use in a patient's eye or on a contact lens inserted into a patient's eye and having a viscosity of 1 to 15,000 centistokes. The composition includes a silicone polymer, fluorinated silicone polymer, fluorocarbon polymer, fluorinated alcohol, or perfluorinated polyether composition, singly or blended, adapted to coat at least a portion of a contact lens inserted in a patient's eye. Silicone polymers for use in the invention include dimethicone, cyclomethicone, and silicone gums.
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PREVENTING SHIN DAMAGE

(WO2005123010) 29.12.2005 A61K 7/00 THE GENERAL HOSPITAL CORPORATION
Disclosed is, inter alia, a method of reducing UVB-induced wrinkles in a subject, the method that includes: administering to a subject having, or at risk for, UVB-induced wrinkle, a composition comprising an agent that inhibits ATR mediated signaling.
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FIBROUS ELASTIC GEL CLEANSING ARTICLE

(WO2005121300) 22.12.2005 C11D 17/04 UNILEVER PLC
An article that is especially suitable for cleansing skin is described which includes a foamable composition having the form of an elastic semi-solid gel and a fibrous layer made up of a continuous network of bonded fibers. The weight ratio of the foamable composition to the fibrous layer is in the range from about 30 to 1 to about 2000 to 1 and the foamable composition at least partially encompasses the fibrous layer.
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BAR SOAP WITH FIBROUS ASSEMBLY

(WO2005121299) 22.12.2005 C11D 17/04 UNILEVER PLC
A cleansing article composed of a solid or semi-solid foamable composition and a batting layer with bonded fibers is described that provides the user with a pleasant personal cleansing experience and which in one embodiment combines cleansing, aesthetic and/or skin benefit with active agents and exfoliation. The user also experiences substantial lather during use of the cleansing article. The batting layer is at least partially encompassed by the solid or semi-solid foamable composition.
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FABRIC CARE COMPOSITION

(WO2005121187) 22.12.2005 C08B 37/00 UNILEVER PLC
The present invention is directed to polysaccharide-grafted polymer particles wherein the polysaccharide is preferably a -1,4 linked polysaccharide and the particle comprises monomer units which may include hydrophobic water insoluble monomer units and/or hydrophilic monomer units, wherein the hydrophilic monomer units are derived from monomers having a solubility of greater than 30 g/litre in water (distilled or equivalent) at 25C.
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FABRIC CARE COMPOSITION

(WO2005121186) 22.12.2005 D06M 15/03 UNILEVER PLC
The present invention is directed to polysaccharide-grafted polymer particles wherein the polysaccharide is a -1,4 linked polysaccharide and the particle comprises monomer units and a preformed polymer, and/or an inorganic solid or organic material.
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BLEACHING COMPOSITION

(WO2005118764) 15.12.2005 C11D 3/42 UNILEVER PLC
A stabilised bleaching composition is provided. The bleaching composition provided comprises a transition metal catalyst together with a UV screen.
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BLEACHING COMPOSITION

(WO2005118763) 15.12.2005 C11D 3/16 UNILEVER PLC
A stabilised bleaching composition is provided. The bleaching composition provided comprises a transition metal catalyst together with a UV screen.
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COSMECEUTICAL FORMULATION CONTAINING PALM OILS

(WO2005118759) 15.12.2005 C11B 3/10 KOPAS, Patricia, McKane
A cosmeceutical formulation is provided that includes a mixture of refined, bleached, deodorized (RBD) palm oils and red palm olein. The resulting formulation is a homogeneous blend with a considerable shelf life. The formulation may be a cream, lotion, sunscreen, or a soap and may be formulated to include additional beneficial oils and EFAs. If a cream formulation is desired, RBD palm stearin is the preferred palm oil for producing a creamy texture. If a lotion is desired, RBD palm oil may be used and chemically modified to produce a tailored oil with a desired melting point and consistency. The formulation may be used to treat a variety of skin conditions including adverse and age-related skin conditions or as an effective moisturizer for...
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SHINY FOUNDATION

(WO2005115327) 08.12.2005 A61K 7/48 THE PROCTER &GAMBLE COMPANY
A cosmetic composition is provided comprising: (e) a cross-linked organopolysiloxane elastomer; (f) a shine agent having the formula R - X - R' wherein R and R' are C6-C10 alkyl groups and X is an oxygen atom or a carbonate group.
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HIGH COVERAGE COSMETIC FOUNDATION

(WO2005115313) 08.12.2005 A61K 7/021 THE PROCTER &GAMBLE COMPANY
A cosmetic foundation composition is provided comprising greater than or equal to 6% by weight of the cosmetic foundation composition of metal oxide particles and having a ?LT value greater than or equal to 0.5, preferably greater than or equal to 1.5, more preferably greater than or equal to 2.5, where ?LT is measured according to the following equation: : ?LT = ?L2 - ?L1 . Where: ?L1 = L1110 L115 ; ?L2 = L2110 - L215 . L1 is a measurement of Ly taken on bare skin, to which no product has been applied; L2 is a measurement of Ly taken on skin, to which product has been applied; and Ly is the luminosity value at a specific angle, y, from specular.
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TRANSLUCENT COSMETIC FOUNDATION

(WO2005115312) 08.12.2005 A61K 7/021 THE PROCTER &GAMBLE COMPANY
A cosmetic foundation composition is provided having a LT value greater than or equal to 3.5, preferably greater than or equal to 4.5, more preferably greater than or equal to 5.0, where ?LT is measured according to the following equation: ?LT = ?L2 - ?L1 . Where: ?L1 = L1110 L115 ; ?L2 = L2110 - L215; L1 is a measurement of Ly taken on bare skin, to which no product has been applied; L2 is a measurement of Ly taken on skin, to which product has been applied; and Ly is the luminosity value at a specific angle, y, from specular.
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COSMETIC FOUNDATION

(WO2005115311) 08.12.2005 A61K 7/021 THE PROCTER &GAMBLE COMPANY
A cosmetic composition is provided comprising: (c) metal oxide particles; and (d)cross-linked, non-emulsifying organopolysiloxane elastomer, wherein organo-functionalised silicone fibrils are bonded to and extend away from the surface of the metal oxide particles.
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FOUNDATION

(WO2005115310) 08.12.2005 A61K 7/021 THE PROCTER &GAMBLE COMPANY
A cosmetic composition is provided comprising (a) metal oxide particles; and (b) greater than 1.7% by weight of the cosmetic composition of cross-linked organopolysiloxane elastomer, wherein organo-functionalised silicone fibrils are bonded to and extend away from the surface of the metal oxide particles.
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PROCESS AND APPARATUS FOR PLASMA COATING, SUBSTRATES COATED BY THIS METOD OR APPARATUS

(WO2005110626) 24.11.2005 B05D 7/24 DOW CORNING IRELAND LIMITED
A method for forming an active material containing coating on a substrate, which method comprises the steps of: i) introducing one or more gaseous or atomised liquid and/or solid coating-forming materials which undergo chemical bond forming reactions within a plasma environment and one or more active materials which substantially do not undergo chemical bond forming reactions within a plasma environment, into an atmospheric or low pressure non-thermal equilibrium plasma discharge and/or an excited gas stream resulting therefrom, and ii) exposing the substrate to the resulting mixture of atomised coating-forming and at least one active material which are deposited onto the substrate surface to form a coating; wherein the substrate is not a w...
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PERSONAL CARE COMPOSITIONS AND METHODS FOR REGULATING MAMMALIAN HAIR GROWTH AND SKIN CONDITION

(WO2005110353) 24.11.2005 A61K 7/48 THE PROCTER &GAMBLE COMPANY
Personal care compositions comprising at least one chronic skin care active selected from the group consisting of butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), hexamidine, hexyl isobutyrate, menthyl anthranilate, methofuran, 3-butylidenepthalide, cetyl pyridinium chloride, green tea extract, catechins, phytosterols, ursolic acid, and plant extract compounds; at least one acute skin care active selected from the group consisting of particulate materials (including particles, pigments, and cross-linked silicone elastomers), panthenol, pantothenic acid derivatives, and tanning actives; and a dermatologically acceptable carrier. The composition can also comprise the cationic thickener, Polyquaternium 37. The present invention ...
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PERSONAL CARE COMPOSITIONS AND METHODS REGULATING MAMMALIAN GROWTH

(WO2005110352) 24.11.2005 A61K 7/48 THE PROCTER &GAMBLE COMPANY
Personal care compositions comprising at least one chronic skin care active selected from the group consisting of butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), hexyl isobutyrate, menthyl anthranilate, methofuran, 3-butylidenepthalide, cetyl pyridinium chloride, green tea extract, catechins, phytosterols, ursolic acid, and plant extract compounds; at least one acute skin care active selected from the group consisting of particulate materials (including particles, pigments, and cross-linked silicone elastomers), alkane polyols, panthenol and pantothenic acid derivatives, and tanning actives; and a dermatologically acceptable carrier. The composition can also comprise the cationic thickener, Polyquaternium 37. The present inv...
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SUBSTITUTED HYDROCARBYL FUNCTIONAL SILOXANES-SILICONE RESINE COMPOSITIONS

(WO2005105925) 10.11.2005 A61K 8/896 DOW CORNING CORPORATION
Cosmetic, household and healthcare compositions containing a hydrocarbyl functional organopolysiloxane are disclosed. The hydrocarbyl functional organopolysiloxane contains at least one siloxy unit of the formula-R2OCH2CH2OH, where R2 is a divalent hydrocarbon group containing 2 to 6 carbon atoms. The inclusion of the hydrocarbyl functional organopolysiloxane results in personal, medical, automotive and household care compositions with improved performance and/or stability.
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COSMETIC FORMULATIONS COMPRISING ZnO NANOPARTICLES

(WO2005104213) 03.11.2005 A61K 8/02 ANDRE, Valerie
The present invention relates to the formation of surface treated zinc oxide and titania particles, and in particular zinc oxide and titania nanoparticles, with a siloxane star-graft copolymer coating, comprising a looped and/or linear polymeric structure on a star-graft copolymer coating, on a particle surface to control the interfacial surface interactions between the particle and the oil phase of the cosmetic skin formulation.
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COSMETIC OR DERMOPHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE UDP GLUCURONOSYL TRANSFERASE (UGT) ENZYMES INDUCER

(WO2005102266) 03.11.2005 A61K 7/48 SEDERMA, SAS
The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect and/or enhance the state of the skin and prevent and/or treat imperfections of the skin.
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SILICONE VESICLES CONTAINING ACTIVES

(WO2005102248) 03.11.2005 A61K 8/14 DOW CORNING CORPORATION
A process is disclosed for preparing silicone visicle compositions containing a personal care or healthcare active, compositions prepared by the inventive process, and formulated products containing the silicone vesicles.
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SUNSCREEN COMPOSITIONS WITH SPF ENHANCER

(WO2005099675) 27.10.2005 A61K 9/42 PLAYTEX PRODUCTS, INC.
The present invention provides a photo-protective composition that has a synergistic combination of at least one sunscreen agent and at least one carotenoid, which results in a composition with an increased SPF compared to a composition without the synergistic combination. Preferably, the composition also has at least one of the following additional components: emulsifier, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof.
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A DISPOSABLE NONWOVEN MITT

(WO2005089611) 29.09.2005 A47K 7/03 THE PROCTER &GAMBLE COMPANY
A disposable nonwoven mitt is adapted to be retained on a user's finger(s) during use. The disposable nonwoven mitt can be associated with a personal care composition. The disposable, nonwoven mitts can be useful for cleansing and/or treating the skin, hair or other similar keratin-containing surfaces. These mitts can be used by the consumer by either wetting a substantially dry mitt with water and then rubbing the mitt against the skin, hair or other similar keratin-containing surfaces, or taking a wet, disposable, nonwoven mitt and rubbing against the skin, hair or other similar keratin-containing surfaces or taking a moist, disposable, nonwoven mitt and rubbing against the skin, hair or other similar keratin-containing surfaces.
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TREATMENT OF KERATINOUS TISSUE

(WO2005087043) 22.09.2005 A45D 44/00 THE PROCTER &GAMBLE COMPANY
A method of treating keratinous tissue is disclosed. The treatment utilizes at least one topical composition for application to keratinous tissue, a sachet containing the topical composition and a receptacle with heating system for releasably receiving at least one sachet.
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SKIN LIGHTENING AGENTS, COMPOSITIONS AND METHODS

(WO2005085169) 15.09.2005 A61K 8/37 UNILEVER PLC
The invention provides coumarin derived compounds of formula (I) as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle : formula (I). Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated, C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated, C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; R5 represents a hydrogen atom (H), or R4; and R4 represents linear or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom, C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heter...
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PERSONAL CARE COMPOSITION COMPRISING HIGHLY BRANCHED PRIMARY ALCOHOL COMPONENT

(WO2005084630) 15.09.2005 A61K 8/34 SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
A personal care composition for topical application to the skin or hair comprising (i) a branched primary alcohol component, having from 8 to 36 carbon atoms and an average number of branches per molecule of from 0.7 to 3.0, said branching comprising methyl and ethyl branches, and said branched primary alcohol component optionally comprising up to 3 moles of alkylene oxide per mole of alcohol; (ii) one or more sunscreens; and (iii) a cosmetically-acceptable vehicle. The personal care compositions of the invention provide excellent sunscreen protection, stability, viscosity and rheology characteristics, together with emolliency, application and skin feel benefits.
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COMPOUNDS DERIVED FROM POLYANHYDRIDE RESINS WITH FILM-FORMING, UV- ABSORBING, AND PHOTOSTABILIZING PROPERTIES, COMPOSITIONS CONTAINING SAME, AND METHODS OF USING THE SAME

(WO2005082961) 09.09.2005 C08F 8/14 CPH INNOVATIONS CORP.
Polymers containing one or more crylene moieties attached to the polymer backbone, sunscreen compositions including a mixture of a photoactive compound and a polymer containing one or more crylene moieties attached to the polymer backbone are described herein. Also disclosed are methods for stabilizing a sunscreen composition and methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing polymers, and methods of waterproofing and forming a film with one or more of the foregoing polymer are described herein.
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PHOTOSTABILIZATION OF A SUNSCREEN COMPOSITION WITH A COMBINATION OF AN a-CYANO-,-DIPHENYLACRYLATE COMPOUND AND A DIALKYL NAPHTHANATE

(WO2005082325) 09.09.2005 A61K 8/35 CPH INNOVATIONS CORP.
Sunscreen compositions including a dibenzoylmethane derivative, such as avobenzone, that are made more stable by the addition of (a) an a-cyano-,-diphenylacrylate compound, e.g., octocrylene and (b) a diester or polyester of naphthalene dicarboxylic acid (diethylhexyl 2,6-naphthalate), having a weight ratio of (a)/(b) of at least 0.95, preferably at least about 1.0. More particularly, the invention relates to sunscreen compositions which utilize a combination of octocrylene and diethylhexyl 2,6-naphthalate to stabilize other photoactive compounds present in a sunscreen composition and, in particular, to stabilize dibenzoylmethane derivatives, without, or with levels less than 0.5% by weight of, a methoxy-substituted benzopheno...
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HIGH SALT COMPOSITIONS, METHODS OF PRODUCING SAME AND METHODS OF USE THEREOF

(WO2005076731) 25.08.2005 A61K 31/74 LOTAN, Amit
The present invention provides high salt in water in oil emulsions, which effectively inhibit the discharge of nematocysts or polar capsules, and a process for preparation of the same. The compositions described herein are also effective at inhibiting nematocyst or polar capsule discharge when reformulated within compositions for topical application prior to exposure to nematocysts.
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COSMETIC AND PHARMACEUTICAL FOAM WITH SOLID MATTER

(WO2005076697) 25.08.2005 A61K 9/00 FOAMIX LTD.
A foamable composition includes about 2 to about 30% by weight solid particles; about 2 to about 75% by weight hydrophobic solvent; about 10 to about 85% by weight water; about 0.1 % to about 5% by weight surface-active agent; about 0.1 % to about 5 wt% by weight stabilizer/gelling agent; and a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical administration.
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IMPROVED DETERGENT COMPOSITION

(WO2005075617) 18.08.2005 C11D 3/12 UNILEVER PLC
The invention relates to a synergistic detergent composition capable of reducing oiliness or greasiness of the skin and also reduce post wash re-accumulation of sebum on the skin. It is particularly preferred to formulate the composition as a wash off product by incorporating a clay belonging to the hormite group of the 2:1 type of clay minerals, and having an inverted ribbon configuration.
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USE OF ACE INHIBITORS AND/OR ANGIOTENSIN II RECEPTOR ANTAGONISTS FOR THE IMPROVING AND/OR MAINTAINING THE SKIN TONE AND FOR THE TREATMENT OF SKIN AGEING

(WO2005072696) 11.08.2005 A61K 8/49 Ace ApS
The present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist of the preparation of a medicament for the treatment of skin ageing or wrinkling. Furthermore, the present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist for the preparation of a cosmetic composition.
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METAL OXIDE PARTICLES USEFUL AS FREE RADICAL SCAVNEGERS IN SUNSCREEN AND COSMETIC COMPOSITIONS

(WO2005072695) 11.08.2005 A61K 8/19 OXONICA, LTD
A composition is described which comprises a component which is susceptible to free radical attack, said composition comprising, as a free radical scavenger, at least one particle having a size not exceeding 100 nm of an oxide of a rare earth or transition metal possessing adjacent oxidation states. The composition is preferable a UV sunscreen composition suitable also for cosmetic use.
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PHENYLETHYL BENZOATE FOR USE IN COSMETICS, TOILETRIES AND PERSONAL CARE PRODUCTS

(WO2005069822) 04.08.2005 A61K 8/00 FINETEX, INC.
Phenylethyl benzoate as a cosmetic ingredient for toiletry and cosmetic formulations, particularly as a diluent, solvent and liquid carrier, as well as an emollient additive, is disclosed. Personal care compositions such as sunscreens and antiperspirants comprising phenylethyl benzoate in the amount of from about 0.5% to about 50% by weight of the composition are disclosed.
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IMPROVED DETERGENT COMPOSITION

(WO2005068594) 28.07.2005 C11D 1/62 UNILEVER PLC
A cleansing composition capable of enhancing deposition of benefit agent comprising: i. a functional oil-in-water emulsion comprising 0.1 % to 5 % by weight benefit agent solubilised/dispersed in an oil and emulsified in water using a cationic emulsifier having an HLB greater than 8 such that the ratio of oil:cationic emulsifier is in the range 20:1 to 1:1; ii. a detergent active composition comprising 5 % to 80 % detergent active; and iii. a cationic polymer.
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PRE-PACKAGED ABSORBENT ARTICLE AND SUN PROTECTION ACCESSORIES

(WO2005067856) 28.07.2005 A61F 13/15 KIMBERLY-CLARK WORLDWIDE, INC.
In a pre-packaged absorbent article and sun protection accessories arrangement, an absorbent article for personal wear, a sunscreen carrier containing a sunscreen composition, and at least one packaging element are arranged relative to each other for distribution together as a single unit. The arrangement may additionally include an ultraviolet (UV) radiation indicator as well as other sun protection accessories such as sunglasses and a hat.
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COSMETIC COMPOSITION CONTAINING A PROTEIN AND AN ENZYME INHIBITOR

(WO2005067691) 28.07.2005 A61K 8/64 GIACOMONI, Paolo U
The present invention is a cosmetic composition comprising a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure capable of undergoing a helix-coil transformation, a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum and a cosmetically acceptable vehicle so that the protease inhibitor prolongs the pulling effect of the film-forming agent.
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A STABILIZED SUNSCREEN COMPOSITION HAVING A PARTICULATE INORGANIC SUNSCREEN

(WO2005065158) 21.07.2005 A61Q 19/00 AVON PRODUCTS, INC.
There is provided a composition. The cosmetic composition has the following: one or more particulates; a neutralized, carboxylic acid polymer selected from the group consisting of a carbomer, acrylates/C10-30 alkyl acrylate crosspolymer, and any combination thereof; an amount of a polyoxyethylene/polyoxypropylene block copolymer effective to stabilize and maintain dispersion of the one or more particulates; and about 10 wt% to about 90 wt% water. There is also provided a method for making a sunscreen composition. There is also provided a method of stabilizing and maintaining dispersion of particulates in a cosmetic composition.
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OIL IN SILICONE EMULSIONS AND COMPOSITIONS CONTAINING SAME

(WO2005065136) 21.07.2005 A61K 8/00 AVON PRODUCTS, INC.
The present invention provides an oil in silicone emulsion and an oil in silicone/water in silicone dual emulsion. These emulsions employ a silicone resin as the emulsifying agent, include an effective amount of one or more active ingredients, such as, a sunscreen and/or insect repellent and provide enhanced aesthetics and SPF. Also provided are methods of preparation of the oil in silicone and the oil in silicone/water in silicone dual emulsions, compositions that employ these emulsions, and methods of using the compositions to repel insects from skin and protect skin from exposure to the sun.
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SUNSCREEN COMPOSITION COMPRISING A MIXTURE OF SILICAS

(WO2005063190) 14.07.2005 A61K 9/06 JOHNSON &JOHNSON INDUSTRIAL LTDA.
The present invention relates to novel compositions for protecting the skin against ultraviolet radiation emissions from the sun and/or from artificial tanning devices. Such compositions are impermeable, tanning and are in the form of a transparent oily gel. Another objective of the present invention is the use of a mixture of hydrophobic and hydrophilic silicas, which actuate as thickening agents in said compositions. Another objective of the present invention is a method of preventing diseases/disturbances of the skin by using said compositions.
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NEW SUNSCREEN COMPOUNDS AND COMPOSITIONS CONTAINING SAME AND METHODS FOR USE THEREOF

(WO2005062860) 14.07.2005 A61K 8/40 AVON PRODUCTS, INC.
There is provided a photostable and synergistically enhanced topical sunscreen composition that provides increased substantivity, waterproofness, sweat resistance and rub off resistance. There is further provided methods of enhancing the photostability of a sunscreen active in a topical sunscreen composition, synergistically enhancing the W absorbance of a topical sunscreen composition having a sunscreen active, and enhancing the substantivity, waterproofness, sweat resistance and rub off resistance in a topical sunscreen composition. The preferred compositions and methods have a sunscreen active, a cosmetically acceptable vehicle, and novel 2- substituted-3,3-diaryl-2-propenoic acid derivatives with [A] a C16 to C50 straight or branche...
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A BASE COMPOSITION FOR PREPARING MULTI-FUNCTIONAL FORMULATIONS FOR CARE AND PROTECTION OF THE SKIN AND HAIR

(WO2005060923) 07.07.2005 A61Q 19/04 NATURA COSMTICOS S.A.
The present invention relates to a cosmetic composition comprising a filmogenic system constituted by at least dimethicone, trimethylsiloxysilicate, stearyl dimethicone, cyclopentasiloxane and dimethiconol, and an emulsifying system constituted by at least PEG-8 dimethicone. This composition imparts to the skin a high resistance to water and to sweat, as well as provides prolonged hydration. In addition, it imparts to user's hair a long time of curl retention, as well as a significant increase in brightness and strengthening of the individual hairs.
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COMPOSITIONS FOR TREATING KERATINOUS SURFACES

(WO2005053634) 16.06.2005 A61K 8/64 REVLON CONSUMER PRODUCTS CORPORATION
A cosmetic composition comprising Acetyl Hexapeptide-3 in a cosmetically acceptable carrier, and use of such cosmetic compositions in improving skin conditions associated with aging such as wrinkles, fine lines, laxity, mottled pigmentation, and sallowness.
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METHOD AND SYSTEM FOR RAPID TRANSDERMAL ADMINISTRATION

(WO2005051476) 09.06.2005 A61M 37/00 ACRUX DDS PTY LTD
Invention relates to a method for transdermal delivery of a topically applied physiologically active agent comprising: providing a micro-projection apparatus comprising an array of microprojections (3) extending from a substrate; applying the array of micro-projections to an area of skin to form an array of microscopic holes therein; and contacting the area of skin with a transdermal composition comprising a physiologically active agent and at least one penetration enhancer wherein the formation of the microscopic holes and penetration enhancer facilitate transdermal delivery of the physiologically active agent.
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STABLE PERSONAL WASH SOAP COMPOSITION AND PROCESS TO PREPARE THE SAME

(WO2005051343) 09.06.2005 A61K 8/44 UNILEVER PLC
A storage stable personal wash soap composition comprising 15-85 % detergent active, 0.1-20 % of skin lightening agent selected from niacin, niacinamide, their precursors and derivatives, and 0.02 % to 2 % of diethylene triamine penta acetic acid (DTPA).
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IMPROVED LOW PH DETERGENT COMPOSITION

(WO2005049782) 02.06.2005 C11D 9/00 UNILEVER PLC
A synergistic low pH cleansing composition comprising: i) 2 % to 30 % of soaps selected from sodium and potassium soap; ii) 30 % to 80 % of soaps selected from magnesium, calcium, zinc and aluminium soaps; and iii) 4 % to 25 % water.
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METHOD AND COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF AMYLOIDOSIS DISORDERS

(WO2005049026) 02.06.2005 A61K 31/00 ACRUX DDS PTY LTD
A method of treatment or prophylaxis of amyloidosis disorders in a patient the method comprising topically applying to an area of skin of the patient a composition comprising: one or more zinc chelators; and one or more dermal penetration enhancers.
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METHOD AND COMPOSITION FOR TREATMENT OF CUTANEOUS LESIONS

(WO2005049025) 02.06.2005 A61K 9/12 ACRUX DDS PTY LTD
A method of treatment or prophylaxis of a cutaneous lesion in an animal the method comprising topically applying to an area of skin of the animal a composition comprising: one or more metal chelators; one or more transforming growth factor modulators; and one or more dermal penetration enhancers.
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COATING APPARATUS AND METHOD

(WO2005048768) 02.06.2005 A45D 44/00 HYDROCO (AUSTRALIA) PTY LTD
The present invention provides an apparatus for applying a composition to the skin, the apparatus including a chamber, the chamber including means for washing the skin (10), and means for applying the composition (4). Applicants have recognised that incorporating means for washing the skin into a chamber designed for applying a composition to the skin provides a number of advantages such as removal of foreign matter from the skin, and also removal of a proportion of the stratum corneum immediately prior to the removal of a composition such as an artificial tanning agent. Removal of dead skin cells and other contaminants from the skin immediately before the application of a composition improves the reproducibility of the absorption of the ac...
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WATER-SOLUBLE POLYAMINOAMIDES COMPRISING 1,3-DIIMINES AS SUNSCREEN AGENTS

(WO2005044948) 19.05.2005 C08K 5/34 NALCO COMPANY
A UV-protective composition comprising a water-soluble polyaminoamide containing 1,3-diimine groups, wherein the polyaminoamide containing 1,3-diimine groups absorbs ultraviolet light radiation having a wavelength of about 200nm to about 420nm, and methods of treating substrates with the UV-protective polyaminoamide containing 1,3-diimine groups.
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SKIN CARE COMPOSITION CONTAINING DEHYDROACETIC ACID AND SKIN CARE ACTIVES

(WO2005044219) 19.05.2005 A61K 8/49 THE PROCTER &GAMBLE COMPANY
Skin care compositions containing dehydroacetic acid, its isomers, salts, and derivatives thereof; at least two skin care actives selected from sugar amines, vitamin B3 compounds, phytosterols, salicylic acid compounds, hexamidines, dialkanoyl hydroxyproline compounds, flavonoids, n-acyl amino acid compounds, and their derivatives, and combinations thereof; and a dermatologically acceptable carrier for the dehydroacetic acid and the skin care actives. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the inv...
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METHOD OF PROVIDING A BLENDED COMPOSITION

(WO2005044218) 19.05.2005 A61K 8/19 THE PROCTER &GAMBLE COMPANY
A method to provide a skin composition comprising at least one salt-form active which is aesthetically pleasing and effective. The method has the steps of providing a first container for a first aqueous phase having at least one salt-sensitive thickener; a second container for a second aqueous phase having at least one salt-form active; and dispensing the first and second phases from their respective containers onto a common surface. The first and second phases are then blended together and applied to the area of the skin in need of treatment.
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IMPROVED COSMETIC COMPOSITION COMPRISING VITAMIN B3, VITAMIN B6 AND AN ORGANIC ACID

(WO2005044214) 19.05.2005 A61K 8/36 UNILEVER PLC
A cosmetic composition is provided comprising vitamin B6, vitamin B3 and an organic acid. The components of the composition interact synergistically to enhance skin lightening.
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IMPROVED MICROEMULSION COMPOSITION

(WO2005042689) 12.05.2005 C11D 3/18 UNILEVER N.V.
The present invention provides a novel cleaning composition in the form of a microemulsion, comprising (a) 5-95% by weight a surfactant with a HLB greater than 8, (b) 0.1-95% by weight of one or more hydrophobic liquids having a net log p value greater than 3.0 and a water solubility less than 0.1%, and (c) 0.05-95% by weight water. Superior cleaning of both oily and particulate soil could be obtained when using a microemulsion of the present invention.
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COMPOSITION FOR PROMOTING SYNTHESIS OF COLLAGEN, AND COMPOSITION FOR EXTERNAL PREPARATION FOR SKIN COMPRISING THE SAME

(WO2005037270) 28.04.2005 A61K 8/02 LG HOUSEHOLD &HEALTH CARE LTD.
The present invention relates to a composition for promoting collagen synthesis and a composition for external application to skin which includes the collagen synthesis promoting composition. The collagen synthesis promoting composition includes, as an effective component, at least one selected from the group consisting of compounds represented as: wherein R is hydrogen, a methoxy group, or a 3-methyl-2-butenyl group. The composition for external application to skin includes at least one collagen synthesis promoting component selected from the group consisting of compounds represented by above.
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METHOD FOR IMPARTING ARTIFICIAL TAN TO HUMAN SKIN

(WO2005034889) 21.04.2005 A61K 8/42 ALLERGAN, INC.
The present invention relates to novel pharmaceutical compositions of bimatoprost and other cyclopentane(ene) heptan(en)oic acid amides and their use in preventing sunburn and/or providing an artificial tan to human skin.
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EFFERVESCENT PERSONAL CLEANSING ARTICLES

(WO2005020952) 10.03.2005 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The invention is for cleansing articles that contain an effervescent foaming composition in a storage stabilized dry form, the composition alternatively being applied for facial and body cleansing article. A kit including a package for storage of the cleansing articles.
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SKIN CARE COMPOSITION INCLUDING HEXAPEPTIDE COMPLEXES AND METHODS OF THEIR MANUFACTURE

(WO2005016364) 24.02.2005 A61K 38/08 GUTHY-RENKER CORPORATION
Skin care compositions disclosed herein include, at a minimum, safe and effective amounts of at least one wrinkle reduction agent and a natural exfoliating complex. The skin care compositions provide natural skin exfoliation, reduce fine lines and wrinkles, and improve skin elasticity and firmness.
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EMULSION COMPOSITION

(WO2005016303) 24.02.2005 A61K 8/04 SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.
An emulsion composition for skin application comprises an aqueous component, one or more water-insoluble organic components totaling at least about 15 percent by weight of the composition, and about 2 to about 10 percent by weight of a solid component consisting of porous silica microspheres having an average particle size between about 5 m and about 20 m.
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REGULATION OF MAMMALIAN KERATINOUS TISSUE USING N-ACYL AMINO ACID COMPOSITONS

(WO2005011627) 10.02.2005 A61K 8/368 THE PROCTER &GAMBLE COMPANY
Skin care compositions containing N-acyl amino acid, particularly N-acyl derivatives of Phenylalanine or Tyrosine, their isomers, or their salts; at least one other skin care active selected from sugar amines, vitamin B3, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, and phytosterol; and a dermatologically acceptable carrier for the N-acyl amino acid and the skin care active. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.
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FOAM CARRIER CONTAINING AMPHIPHILIC COPOLYMERIC GELLING AGENT

(WO2005011567) 10.02.2005 A61K 9/107 FOAMIX LTD.
The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier including water, a hydrophobic solvent, a surface-active agent and a gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.
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COATING COMPOSITIONS COMPRISING EPOXY RESINS AND AMINOFUNCTIONAL SILICONE RESINS

(WO2005010115) 03.02.2005 C08K 5/17 DOW CORNING CORPORATION
This invention relates to a coating composition comprising (A) 100 weight parts of at least one epoxy resin; (B) 3-300 weight parts of at least one aminofunctional silicone resin; (C) up to 50 weight parts of at least one organic hardener; (D) up to 100 weight parts of at least one epoxyfunctional silicone resin; and (E) up to 10 weight parts of at least one cure accelerator. The coating compositions of this invention have acceptable moduli (>100MPa ), are tough, flexible, solvent and water resistant over a broad temperature range.
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MICROCAPSULES LOADED WITH ACTIVE INGREDIENTS AND A METHOD FOR THEIR PREPARATION

(WO2005009604) 03.02.2005 A61K 8/11 SOL-GEL TECHNOLOGIES LTD.
The invention relates to microcapsules having a core material encapsulated within a microcapsular shell, the core material comprises at least one active ingredient, wherein the microcapsular shell comprises at least one inorganic polymer comprising polymerized precursors obtained by in-situ polymerization of the precursors; wherein the concentration of the core material based total weight of the microcapsules is above 95% w/w. The invention further relates to a composition and to a suspension comprising the microcapsules. The invention additionally relates to a process for preparing the microcapsules.
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COMPOSITIONS CONTAINING PHENETHYL ARYL ESTERS AS SOLUBILIZING AGENTS FOR ACTIVE ORGANIC COMPOUNDS

(WO2005009341) 03.02.2005 A61K 8/37 ISP INVESTMENTS INC.
An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.
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SUSTAINED RELEASE COMPOSITIONS AND CONTROLLED DELIVERY METHOD

(WO2005004832) 20.01.2005 A61K 9/14 LIPO CHEMICALS INC.
A sustained release composition comprising cellulose fibers, an active agent, and an optional release retardant is disclosed. The composition has an improved ability to stabilize and release the active agent over an extended time period.
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CLEANSING ARTICLE HAVING AN EXTRUDED LOW DENSITY FOAM LAYER

(WO2005002539) 13.01.2005 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention is directed to a disposable article that contains a plurality of substrate layers where at least one of the layers is an extruded low density foam and the article has a cleansing composition associated with the substrate layers. The article provides effective cleansing benefits to the skin and hair in a convenient, inexpensive, and sanitary manner. The article of the present invention also has superior thickness. The article has increased rigidity while at the same time is flexible. The increase in rigidity and thickness provides for an article that does not crush or crumple during use. The low density provides for an article that has improved handleability and reduced scratchy feel against the skin. The article of the...
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METAL OXIDE FORMULATIONS

(WO2005002538) 13.01.2005 C09D 5/32 OXONICA LIMITED
A composition is described which comprises an ingredient which is adversely affected by the presence of TiO2 and/or ZnO, and TiO2 and/or ZnO which has been doped with another element and/or reduced ZnO.
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COMPOSITIONS AND METHODS FOR TREATMENT OF ROSACEA

(WO2005000337) 06.01.2005 A61K 38/06 PROCYTE CORPORATION
A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.
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FUNCTIONALIZED POLYALPHAOLEFINS

(WO2004113403) 29.12.2004 C08F 10/14 BAKER HUGHES INCORPORATED
Disclosed is a composition of a functionalized polyalphaolefin comprising the reaction product of admixing (a) an alpha-olefin monomer having at least 10 carbon atoms; (b) an unsaturated functionalizing compound; and (c) a polymerization initializer, under reaction conditions sufficient to polymerize the alpha-olefin monomer and unsaturated functionalizing compound. Free radical initiators, especially peroxides are disclosed to be useful in preparing the functionalized polyalphaolefin. The functionalized polyalphaolefins are disclosed to be useful in preparing inks, toners, coatings, candle waxes, lubricating oils, and personal care products.
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A CLEANSING ARTICLE WITH IMPROVED HANDLEABILITY

(WO2004112734) 29.12.2004 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention is directed to a disposable article that contains a plurality of substrate layers. The article is selected from the group consisting of pad sized articles, grip sized articles, sheet sized articles and combinations. These articles have a cleansing composition associated with the substrate layers. The articles provide effective cleansing benefits to the skin and hair in a convenient, inexpensive, and sanitary manner. The articles of the present invention also have superior thickness. Additionally, the article has increased rigidity while at the same time is flexible. The increase in rigidity and thickness provides for an article that does not crush or crumple during use. The article of the present invention can also pro...
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NOVELL PHOTOSTABILIZERS, UV ABSORBERS, AND METHODS OF PHOTOSTABILIZING A SUNSCREEN COMPOSITION

(WO2004110394) 23.12.2004 A61K 8/35 CPH Innovations Corp.
Derivatives of fluorene, including ester derivatives of cyano(9H-fluoren-9-ylidene) acetic acid, and sunscreen compositions including a mixture of a photoactive compound and an ester derivative of cyano(9H-fluoren-9-ylidene) acetic chain with an ester derivative of cyano(9H-fluoren-9-ylidene) acetic acid and methods of filtering out ultra-violet light from a substrate by the use of one or more such derivatives.
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SUNSCREEN COMPOSITION

(WO2004110366) 23.12.2004 A61K 7/00 SUN PHARMACEUTICALS CORPORATION
There is provided a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Rating, photostability, or any combinations thereof, of the composition. Subsequently, an efficient sunscreen composition is achieved.
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SKIN LIGHTENING COMPOSITION COMPRISING AN EXTRACT OF PLANTS FROM THE FAMILIES OF SYMPLOCOS OR RUBIA

(WO2004105718) 09.12.2004 A61K 8/97 UNILEVER PLC
A cosmetic skin lightening composition, comprising 0.1 - 50 % by weight of an extract of plants from the families of Symplocos, Rubia or a mixture thereof.
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PHOTOSTABLE ORGANIC SUNSCREEN COMPOSITION

(WO2004105712) 09.12.2004 A61K 7/42 MERCK PATENT GMBH
The present invention relates to a sunscreen capsule comprising i) at least one UV-A organic sunscreen and ii) at least one photostabilizer; furthermore it relates to a composition for topical application comprising these capsule and methods of production and use of these capsules and compositions.
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EMULSION BASE FOR SKIN CARE COMPOSITIONS

(WO2004105704) 09.12.2004 A61K 7/00 SUN PHARMACEUTICALS CORPORATION
The present invention is directed to an emulsion base for formulating cosmetic and dermatological compositions. The emulsion base has particular surfactant and/or emulsifier ratios such that a wide range of compositions with varying forms and additional components can be formulated without changing the ratio or amount of the primary and/or co surfactant/emulsifier in the emulsion base or the amount of the emulsion base in the final composition. The emulsion base can be used in a system of formulating cosmetic and dermatological compositions.
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SLIMMING COSMETIC COMPOSITION COMPRISING CAFESTOL OR KAHWEOL

(WO2004103334) 02.12.2004 A61K 8/49 SEDERMA
Cosmetic or demopharmaceutical compositions containing, in a dermatologically acceptable carrier, at least one diterpene among: cafestol, kahweol and chemical derivatives are useful for slimming treatments including prevent and/or treat cellulite or orange peel and/or to refine contours of the face, skin firming, to reduce the steatomery of the thighs, to decrease the volume/fatty overload of the spare tire at the hips, to reduce 'love handles', both on men and women.
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PERSONAL CARE PRODUCTS COMPRISING ACTIVE AGENTS IN A GEL NETWORK

(WO2004103323) 02.12.2004 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a personal care product containing a polymeric gel network produced by the process of crosslinking an organopolysiloxane polymer and swelling the organopolysiloxane polymer to form a gel network by introducing liquids including one or more active agents, where the active agents are entrapped in the gel network. The liquids of the product may optionally include one or more solvents.
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COMPOSITIONS COMPRISING AN AMIDINE AND AN ALKANE POLYOL

(WO2004103290) 02.12.2004 A61K 8/34 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions containing an amidine, an alkane polyol having a ClogP of from +0.2 to +1.55 and water. The present invention also relates to methods of using such cosmetic compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.
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SUNSCREEN OR MEDICINAL WIPES HAVING HIGH SUNSCREEN FORMULATION TRANSFER RATE

(WO2004100914) 25.11.2004 A61K 8/02 KIMBERLY-CLARK WORLDWIDE INC.
Sunscreen wipes comprising a thixotropic, quick-breaking sunscreen formulation are disclosed. The sunscreen formulation comprises water, at least one sunscreen active, Pemulen TR-2, a stabilizing emulsifier, and a neutralizing agent. By formulating the sunscreen formulation such that it has specific high shear and low shear viscosities at a pH range of from about 5 to about 6, the transfer rate of the sunscreen formulation to the skin during use is significantly increased as compared to conventional sunscreen wipes. The present invention is further directed to a medicinal wipe comprising a wipe substrate and a medical formulation. The medicinal formulation comprises water, Permulen TR-2, high spreadability emollient, medicinal active (such ...
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COMPOSITIONS AND METHODS FOR TREATMENT OF PSORIASIS

(WO2004096258) 11.11.2004 A61K 33/34 PROCYTE CORPORATION
A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.
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STABILIZED DERIVATIVES OF ASCORBIC ACID

(WO2004094369) 04.11.2004 A61K 31/34 TAGRA BIOTECHNOLOGIES LTD.
Ascorbic acid derivatives of the general formula I: wherein R1 is a C2-C22 acyl group, an amino acid group, or a C1-C17 alkyl group; R2 is ammonium or a metal cation; and each of R3 or R4, independently, is hydrogen, a C2-C22 acyl group, an amino acid residue, or a C1-C17 alkyl group, are more stable than ascorbic acid and can be used as a source of vitamin C in pharmaceutical, nutraceutical and cosmetic compositions.
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COMPOSITIONS AND METHODS FOR REGULATING MAMMALIAN KERATINOUS TISSUE

(WO2004093841) 04.11.2004 A61K 8/44 THE PROCTER &GAMBLE COMPANY
Skin care compositions and methods of regulating the condition of mammalian keratinous tissues containing an effective amount of dialkanoyl hydroxyproline compound and a second skin care compound selected from hexamidine compounds, sugar amine compounds and their compound. These compositions may be either an emulsion or a solution wherein the dialkanoyl hydroxyproline compound may be converted to its salt for incorporation into the aqueous phase of a compositions.
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SKIN-TIGHTENING PREPARATIONS CONTAINING GLIADIN

(WO2004093837) 04.11.2004 A61K 8/64 MGP INGREDIENTS INC.
The present invention is concerned with preparations for application to human skin including a cream or lotion base together with a quantity of a skin-tightening agent consisting essentially of gliadin. Products such as creams, lotions, facial masks and sunscreens can be prepared which exhibit desirable skin-tightening or anti-wrinkle effects.
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TOPICAL TREATMENT OF DERMATOLOGICAL DISORDERS ASSOCIATED WITH REACTIVE OR DILATED BLOOD VESSELS

(WO2004093722) 04.11.2004 A01N 37/00 YU, Ruey, J.
The invention provides a method of topically treating a dermatological disorder. The method includes topically applying a therapeutically effective amount of a cosmetic or dermatological composition to an affected area of the skin. The composition includes at least one compound that is (i) a polyhydroxy-aldonic acid, (ii) a polyhydroxy-aldonic lactone, (iii) a polyhydroxy-alduronic acid, (iv) a polyhydroxy-alduronic lactone, (v) a polyhydroxy-aldaric acid; (vi) a polyhydroxy-aldaric lactone, and (vii) an organic acid lactone having two or more hydroxyl or ketohydroxyl groups. The dermatological disorder treated is one associated with reactive or dilated blood vessels. Also included in the invention are methods of treating dermatological dis...
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CATIONIC, OXIDIZED POLYSACCHARIDES IN CONDITIONING APPLICATIONS

(WO2004091557) 28.10.2004 A61K 8/73 HERCULES INCORPORATED
A cationic, oxidized polysaccharide or derivative thereof that has a mean average molecular weight (Mw) having a lower limit of 50,000 and an upper limit of 1,000,000 and an aldehyde functionality content of at least 0.001meq/gram is used in personal care and household care compositions. This cationic, oxidized polysaccharide is prepared in continuous or batch processes using hydrolytic reagents, oxidizing reagents, or combination of hydrolytic reagents and oxidizing reagents. Personal care or household care compositions are prepared by adding the cationic, oxidized polysaccharide to a personal care or household composition containing at least one active ingredient other than the cationic, oxidized polysaccharide of this invention.
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TOPICAL COMPOSITIONS COMPRISING N-ACETYLAMINO ACIDS OR RELATED N-ACETYL COMPOUNDS

(WO2004089329) 21.10.2004 A61K 8/41 YU, Ruey, J.
Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.
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PRESERVED AND STABLE COMPOSITIONS CONTAINING PEPTIDE COPPER COMPLEXES AND METHODS RELATED THERETO

(WO2004087740) 14.10.2004 A61K 8/19 PROCYTE CORPORATION
Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to microbial growth, when the preservative is selected to be a non-formaldehyde-donating preservative. In other embodiments, the present invention is directed to such compositions that are formulated for use as pharmaceuticals and cosmetic products, and to medical devices comprising a disclosed composition. In another aspect, the present invention is also directed to a method for imparting to a composition comprising at least one peptide copper complex, chemical stability as well as resistance and/or toxicity to microbial growth, where the method comprises i...
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COSMETIC COMPOSITIONS COMPRISING PHYTOSTEROL ESTERS

(WO2004084646) 07.10.2004 A61K 8/63 ENZYMOTEC LTD.
The present invention generally relates to novel solid oil-based compositions for cosmetic applications and their production. In particular, the present invention provides novel non-aqueous lipid-based compositions for cosmetic applications containing a mixture of diglyceride(s), phytosterol ester(s) (PSE), and optionally monoglyceride(s), dissolved or dispersed in an oil, for example olive oil. The present invention also provides a process for preparing the novel composition compositions, and to various cosmetic uses of these novel compositions, for example ant-aging, anti-chapping, anti-irritancy, skin moisturizing/softening, line/wrinkle reduction and/or sunscreen protection.
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IMPROVED BIOAVAILABILITY AND IMPROVED DELIVERY OF ACIDIC PHARMACEUTICAL DRUGS

(WO2004082628) 30.09.2004 A61K 31/19 YU, Ruey, J.
Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an acidic pharmaceutical drug and at least one functional substance. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.
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IMPROVED BIOAVAILABILITY AND IMPROVED DELIVERY OF ALKALINE PHARMACEUTICAL DRUGS

(WO2004080468) 23.09.2004 A61K 8/365 YU, Ruey, J.
Embodiments of the invention relate to a composition, a process of making the composition, and to the use of the composition. The compositions include a molecular complex formed between an alkaline pharmaceutical drug and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compositions provide improved bioavailability and improved delivery of the drug into the cutaneous tissues.
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THERAPEUTIC, NUTRACEUTICAL AND COSMETIC APPLICATIONS FOR EGGSHELL MEMBRANE AND PROCESSED EGGSHELL MEMBRANE PREPARATIONS

(WO2004080428) 23.09.2004 A61K 8/98 NEW LIFE RESOURCES, LLC
The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.
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USE OF REPEAT SEQUENCE PROTEIN POLYMERS IN PERSONAL CARE COMPOSITIONS

(WO2004080426) 23.09.2004 A61K 8/64 DOW CORNING CORPORATION
A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.
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REGULATION OF MAMMALIAN KERATINOUS TISSUE USING HEXAMIDINE COMPOSITIONS

(WO2004078158) 16.09.2004 A61K 8/34 THE PROCTER &GAMBLE COMPANY
The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a hexamidine compound selected from the group consisting of hexamidine, its salts, and derivatives; b) a safe and effective amount of one or more skin care active selected from the group consisting of sugar amine, vitamin B3, retinoid, peptide, phytosterol, butylated hydroxytoluene and butylated hydroxyanisole, their derivatives, and combinations thereof; and c) a dermatologically acceptable carrier for the hexamidine ...
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REGULATION OF MAMMALIAN HAIR GROWTH

(WO2004078157) 16.09.2004 A61K 8/34 THE PROCTER &GAMBLE COMPANY
The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives; and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mamma...
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INVISIBLE PATCH FOR ACTIVE AGNET CONTROLLED DELIVERY

(WO2004078122) 16.09.2004 A61F 13/00 SALVONA LLC
The present invention relates to a patch for controlled topical or transdermal delivery of effective levels of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin, hair follicles, and sebaceous glands, with minimal discomfort and ease of use. The patch can be transparent or clear and comprises a rate-controlling matrix layer. The matrix layer comprises water-sensitive, bioadhesive, film forming polymers, a water soluble oligomer, and a surfactant. The cosmetic, dermatological, and pharmaceutical active ingredients are soluble or dispersed in the matrix. The patch becomes tacky when wetted and adheres onto the skin. The adhesive properties of the patch are sufficient to maintain the patch in place on the skin for th...
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COSMETIC UV-SCREEN COMPOSITIONS AND AMINOBUTADIENE-BASED UV-ABSORBING COMPLEXES THEREFOR

(WO2004075871) 10.09.2004 A61K 8/49 FUJI PHOTO FILM B.V.
This invention relates to a cosmetic composition for protection against UV radiation and its detrimental effects comprising a cosmetically and dermatologically acceptable carrier and a UV absorbing compound, not being flavonoid, which is covalently linked to a carrier molecule.
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SALICYLIC ACID DERIVATIVE AS EFFICACY ENHANCER AND METHOD

(WO2004073745) 02.09.2004 A61K 47/14 L'ORAL
The present invention relates to compositions containing at least one salicylic acid derivative and at least one cosmetic, dermatologic, pharmaceutical, etc. active agent, where the salicylic acid derivative increases, enhances, etc., the efficacy of the active agent, as well as to methods of making and using such compositions. The invention further relates to a method for enhancing the efficacy of active agents with these salicylic acid derivatives.
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FILM FOAMING HYDROALCOHOLIC FOAM

(WO2004071479) 26.08.2004 A61K 8/04 CONNETICS AUSTRALIA PTY LTD
The present invention prodides a foam composition comprising an active agent. In particular, the foam composition produces a water resistant, preferably very water resistant, film upon application
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IN VITRO PREDICTION OF SUNSCREEN PFA VALUES

(WO2004071455) 26.08.2004 A61B 5/05 SUN PHARMACEUTICALS CORPORATION
An in vitro method for the prediction of in vivo UVA protection by a composition with sunscreen properties. The method includes the steps of : Determining in vivo SPF : determining in vitro SPF based on the sunscreens absorbance spectrum in the UV region; normalizing the absorbence spectrum based on integration area of UVA1; and calculating the PFA-PPD in vitro.
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NOVEL STABILIZED CINNAMIC ESTER SUNSCREEN COMPOSITIONS

(WO2004069216) 19.08.2004 A61K 8/11 DSM IP ASSETS B.V.
The invention relates to a method of enhancing the photostability of an encapsulated cinnamate derivative in a topical sunscreen composition which comprises introducing into such sunscreen composition an effective amount of at least one additional non-encapsulated sunscreen.
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SKIN LIGHTENING COMPOSITION

(WO2004066973) 12.08.2004 A61K 8/36 UNILEVER PLC
A skin lightening composition comprising: a) 0.05 to 10 % by weight of one of more of vitamin B3 compounds or its derivatives thereof; b) 0.01 to 10 % by weight of allantoin; and c) a cosmetically acceptable vehicle or 15 % to 85 % by weight detergent active.
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NON-LETHAL TEMPORARY INCAPACITATION FORMULATION AND NOVEL SOLVENT SYSTEM

(WO2004062641) 29.07.2004 G08B 15/02 ZARC INTERNATIONAL, INC.
A non-lethal temporarily incapacitating formulation having a new solvent system that has reduced blow back longer hang time when used as an aerosol spray. The solvent and formulation are non-toxic, non-hazardous, non-flammable, highly stable, environmentally safe and able to withstand extreme operating temperatures. The solvent system is a mixture of propylene glycerol dicaprylate/caprate and glycerol tris (2-ethylhexanoate) and is suitable for use for a wide range of automotive, household and industrial applications.
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MULTIFUNCTIONAL COMPOSITIONS FOR SURFACE APPLICATIONS

(WO2004060330) 22.07.2004 C11D 17/00 KIMBERLY-CLARK WORLDWIDE, INC.
The present invention relates to the preparation of surface cleaning and protection compositions. A typical embodiment of this invention may be a lotion, a soap, a cream, an aerosol, a gel, a medicinal lotion, a fabric cleanser, a furniture polish, an automobile polish, and a cleanser for other solid surfaces. The use of polyhederal oligomeric silsequioxane (POSS) allows greater flexibility in delivering active agents to a surface as well as for surface protection from irritants. The current invention discloses compositions for a variety of applications ranging from skin care, home hygiene, health care, entertainment, and children training/education. The compositions may provide molecular-level benefits, form breathable protection layers on...
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SKIN CARE COMPOSITION CONTAINING AN ANIONIC POLYMER

(WO2004060273) 22.07.2004 A61K 8/81 NALCO COMPANY
A cosmetically acceptable composition for treating skin comprising about 0.1 to about 20 weight percent, based on polymer solids, of an anionic polymer composed of from about 10 to about 80 mole percent of 2-acrylamido-2-methyl-l-propanesulfonic acid or a base addition salt thereof and from about 90 to about 20 mole percent of one or more anionic or nonionic monomers.
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CLOTH-LIKE PERSONAL CARE ARTICLES

(WO2004058214) 15.07.2004 A47K 10/32 THE PROCTER &GAMBLE COMPANY
The article contains a fibrous, non-woven web and having a personal care composition associated with this web. The present invention relates to disposable, personal care articles useful for cleansing and/or treating the skin, hair or other similar keratin-containing surfaces. These articles are used by the consumer by either wetting the dry article with water and then rubbing the article against the skin, hair or other similar keratin-containing surfaces, or taking a wet, disposable, personal care article and rubbing against the skin, hair or other similar keratin-containing surfaces or taking a moist, disposable, personal care article and rubbing against the skin, hair or other similar keratin-containing surfaces.
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SUNSCREENS

(WO2004058209) 15.07.2004 A61K 8/27 OXONICA LIMITED
A UV sunscreening composition suitable for cosmetic or topical pharmaceutical use which comprises an amount of one or more organic components which are photosensitive and/or which are degraded and/or in which degradation is induced by another ingredient of the composition, and an amount of TiO2 and/or ZnO which has been doped with another element and/or reduced zinc oxide, this composition having a rate of loss of UV absorption at least 5% less than that of a composition having the same formulation except that it does not contain the said TiO2 and/or ZnO which has been doped with another element or the said reduced zinc oxide.
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POWDER MIXTURE CONSISTING OF TITANIUM DIOXIDE, ZINC OXIDE AND ZINC/TITANIUM MIXED OXIDE

(WO2004056706) 08.07.2004 C01G 23/00 DEGUSSA AG
A powder mixture consisting of zinc/titanium mixed oxide particles, titanium dioxide particles and zinc oxide particles, wherein the zinc/titanium mixed oxide particles have a composition according to the formula (ZnO)1-x(TiO2)x, where 0.01 < x < 0.99, and are obtained from a thermal process and the powder mixture exhibits remission which, in the UV range from 320 to 400 nm, is lower than that of titanium dioxide and, in the UV range below 320 nm, is lower than that of zinc oxide. The powder mixture may be produced by introducing into a flame, as is used for the production of pyrogenic metal oxides by means of flame hydrolysis, an aerosol of a zinc compound, homogeneously mixing said aerosol with the flame hydrolysis gas mixture, allowing t...
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AQUEOUS-ALCOHOLIC DEPIGMENTING GEL CONTAINING A PHENOLIC DERIVATIVE AND A RETINOID

(WO2004052353) 24.06.2004 A61K 9/06 GALDERMA RESEARCH &DEVELOPMENT, SNC
The invention relates to a depigmenting composition for cosmetic or pharmaceutical application, comprising a phenolic derivative, a retinoid, especially a dispersed retinoid, and optionally a sunscreen in the form of an aqueous-alcoholic gel, to the process for preparing it and to its use in cosmetics and dermatology.
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SKIN LIGHTENING DERIVATIVES OF DI-THIANE RESORCINOL, COMPOSITIONS AND METHODS

(WO2004052330) 24.06.2004 A61K 7/48 UNILEVER PLC
Cosmetic compositions and methods of skin lightening using compounds of formula ( I) as skin lightening agents, wherein X represents carbon, nitrogen, sulphur or oxygen;each A1 and/or A2 independently is = H or COR, CO2R ,CONHR having the following formula (A), where R= C1-C18 saturated or unsaturated, linear or branced, hydrocarbon; andeach Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z= H or COR1, CO2R1,CONHR1 of formula (B), and where R1 = C1-C18 saturated or unsaturated, linear or branched, hydrocarbon.
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DI-SUBSTITUTED RESORCINOLS AS SKIN LIGHTENING AGENTS

(WO2004052329) 24.06.2004 A61K 8/27 UNILEVER PLC
Cosmetic compositions and methods of skin lightening using compounds of formula (I), as skin lightening agents, wherein:each X1 and/or X2 ,independently, is = H or COR, CO2R ,CONHR groups represented by the formula (A), where R= C1-C18 saturated or unsaturated linear or branched hydrocarbon, and each R1 and/or R2, independently is a C1-C18 saturated or unsaturated, linear or branched, hydrocarbon group.
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NOVEL SKIN LIGHTENING AGENTS, COMPOSITIONS AND METHODS

(WO2004052316) 24.06.2004 A61K 8/49 UNILEVER PLC
Compounds of formula (I), process for making the same, and cosmetic compositions and methods of skin lightening using compounds of formula (I) as skin lightening agents: (I) wherein each A1 and/or A2 independently is = H or COR, CO2R, CONHR, the latter three having the following formula (A): (A) where R = C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z = H or COR1, CO2R1, CONHR1 of formula (B): (B) and where R1 = C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is carbon, nitrogen, sulphur, or oxygen; and N is in integer between 0 and 2.
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MIXED ESTERS OF DICARBOXYLIC ACIDS FOR USE AS PIGMENT DISPERSANTS

(WO2004052076) 24.06.2004 A61K 7/00 SMITH, Ronald, J.
Novel mixed esters of dicarboxylic acids with monohydric fatty alcohols and propoxylated pigments used in foundations, make-ups, lipsticks and physical sunscreens. The compounds of the present invention show superior pigment wetting and dispersing properties, as demonstrated by their ability to form fluid, very high-solids dispersions, while exhibiting unusual emolliency and gloss formation. The novel compounds of this invention have the structural formula (I), wherein R1 is as the structural formula (II), wherein: R4 is a saturated or unsaturated, substituted or unsubstituted moiety containing from 4 to 24 carbon atoms; X is an integer from 3 to 30; R2 is a saturated or unsaturated, substituted or unsubstituted aliphatic moiety which conta...
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SUNSCREEN COMPOSITION FOR TOPICAL APPLICATION

(WO2004050050) 17.06.2004 A61K 8/35 UNILEVER PLC
A sunscreen composition for topical application containing an absorber for radiation at the wavelengths 475 to 515 nm and 595 to 610 nm, wherein the absorber is a dye or mixture of dyes
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ANTI-AGING SKIN CARE COMPOSITION AND USES THEREOF

(WO2004043469) 27.05.2004 A61K 8/44 KLYSZ, Beatrice, M.
The present invention is directed toward anti-aging skin care compositions comprising Vitamin Bl, Vitamin B5, Vitamin C, N-acetyl-cysteine and, optionally, lipoic acid. The present invention is further directed toward methods for therapeutically or prophylactically treating the consequences of aging on the condition or appearance of the skin. The present invention further provides one or more kits that are useful for delaying, treating or preventing the consequences of aging on the condition or appearance of the skin.
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IMPROVED COSMETIC COMPOSITION

(WO2004043422) 27.05.2004 A61K 7/48 UNILEVER PLC
A skin care cosmetic composition comprising: a. 0.05 % to 5 % by weight vitamin B12 or a derivative thereof; b. 0.1 % to 10 % by weight of a skin lightening vitamin chosen from niacinamide, pyridoxine or precursors thereof; c. up to 10 % by weight sunscreen; and d. 10 % to 99 % by weight of a cosmetically acceptable vehicle or 15 % to 85 % by weight detergent active.
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STIMULATION OF HAIR GROWTH BY COMPOSITIONS CONTAINING PEPTIDE COPPER COMPLEXES AND MINOXIDIL

(WO2004043415) 27.05.2004 A61K 7/06 PROCYTE CORPORATION
Disclosed are compositions, useful for stimulating hair growth in warm-blooded animals in need thereof, that combine at least one peptide copper complex and Minoxidil. The disclosed compositions may be formulated so as to be suitable for topical application or for intradermal injection to areas of skin in need thereof. Also disclosed are methods for stimulating hair growth to thereby treat various hair growth afflictions, such as androgenetic alopecia, alopecia areata, or secondary alopecia. Generally, the disclosed methods comprise applying, topically or via intradermal injection, a stimulatory effective amount of a disclosed composition to an area of a patient's skin in need thereof. In one embodiment, the disclosed method employs such ap...
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WATER SOLUBLE MONOMERS AND POLYMERS FOR PROTECTING SUBTRATES FROM ULTRAVIOLET LIGHT

(WO2004043412) 27.05.2004 A61K 31/74 NALCO COMPANY
A UV-protective composition for treating substrates comprising one or more water-soluble, cationic, UV-absorbing polymers, wherein the cationic, UV-absorbing polymers are prepared by polymerizing one or more vinyl, allyl or acrylic monomers with one or more vinyl or acrylic monomers that absorb ultraviolet light radiation having a wavelength of about 200 to about 420 nm and a method of treating substrates.
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A MULTI COMPONENT CONTROLLED DELIVERY SYSTEM FOR SOAP BARS

(WO2004041991) 21.05.2004 C11D 9/00 SALVONA LLC
The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The high cationic charge density on the nanosphere surface is create...
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TOPICAL ANHYDROUS DELIVERY SYSTEM FOR ANTIOXIDANTS

(WO2004041234) 21.05.2004 A61K 8/58 MERCK PATENT GmbH
This invention relates to an anhydrous composition comprising an antioxidant comprising over 40% by weight of hydrolysable tannins having molecular-weight of less than 1,000 and a substantially anhydrous or non-aqueous liquid vehicle functioning to disperse the antioxidant. The antioxidant composition is particulary an extract of Phyllanthus emblica, containing Emblicanin A, Emblicanin B, Pendunculagin and Punigluconin. The liquid vehicle is preferably a composition and/or therapeutic and/or prophylactic composition and/or anhydrous delivery system of cosmetic and/or pharmaceutical ingredients. The invention further relates to processes for producing such compositions.
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COMPOSITIONS AND METHODS FOR PREVENTION OF PHOTOAGING

(WO2004041168) 21.05.2004 A01N 43/54 BERNSTEIN, Eric, F.
Methods of preventing photoaging and sun burn by topically applying a composition containing caffeine or a compound structurally similar to caffeine are provided. Pharmaceutical compositions comprising caffeine or a compound structurally similar to caffeine for the prevention of photoaging and sun burn are also provided.
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METHOD AND APPARATUS FOR DETERMINING EFFECTIVENESS OF SUNSCREENS AND OTHER SKIN PREPARATIONS IN SHIELDING HUMAN SKIN FROM UVA RADIATION

(WO2004039414) 13.05.2004 A61K 49/00 RAFT TRUSTEES LTD.
The present invention provides a method and apparatus for measuring the effectiveness of a sunscreen composition or other skin preparation in reducing the exposure of human skin to UVA radiation, wherein differential electron spin resonance spectroscopy is used to quantify the extent of UVA--induced ascorbate or other measurable radical production in the shielded skin, in comparison with reference, preferably unshielded, skin.
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COSMETIC AND PHARMACEUTICAL FOAM

(WO2004037225) 06.05.2004 A61K 8/04 FOAMIX LTD.
The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.
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THE USE OF BIOMIMIC POLYMERS IN PERSONAL CARE COMPOSITIONS

(WO2004035012) 29.04.2004 A61K 8/72 CIBA SPECIALTY CHEMICALS HOLDING INC.
The present invention relates to the use of biomimic polymeric and/or oligomeric peptides (also known as facially amphiphilic polymers) as antimicrobially active substances in home and personal care applications, i.e. in products that are used to clean, condition and/or enhance keratinic substrates such as human skin, hair, nails, etc., and formulations of various such products containing the subject antimicrobially active substances.
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METHOD AND ARTICLE FOR APPLYING AND MONITORING A SURFACTANT

(WO2004026999) 01.04.2004 C11D 11/00 B-NEW LTD.
The present invention is directed to a method and an article for performing the method of monitoring a surfactant. A preferred embodiment of the invention, an article comprises a substrate having an image and a surfactant thereon. The substrate is formed from various known fabrics or materials capable of absorbing and retaining a substantial quantity of the surfactant. During use, as the surfactant is dissipated, the image changes in appearance thereby indicating the quantity of surfactant remaining on the substrate. In a preferred embodiment of the invention, the method and article of the present invention is effective for encouraging and making washing enjoyable for children and includes the use of an epidermal surfactant, such as soap, d...
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COSMETIC COMPOSITION CONTAINING MICROCRYSTALLINE CELLULOSE

(WO2004026263) 01.04.2004 A61K 8/04 FMC CORPORATION
A sprayable cosmetic composition is disclosed. In one aspect, the composition comprises a sunscreen agent or mixture of sunscreen agents; an emulsifier or mixture of emulsifiers; optionally an emollient or mixture of emollients; a rheology control agent; and water. The rheology control agent is microcrystalline cellulose. When sprayed on the skin or hair, the cosmetic compositions of the invention produce a fine mist that deposits evenly with no dripping and no aggregate or blobs.
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NOVEL PHOTOSTABILIZERS, UV ABSORBERS, AND METHODS OF PHOTOSTABILIZING A SUNSCREEN COMPOSITION

(WO2004026197) 01.04.2004 A61K 8/35 CPH INNOVATIONS CORPORATION
Polymers and compounds including a diphenylmethylene or a 9H-fluorene moiety; and sunscreen compositions including a mixture of a photoactive compound and any one of the foregoing derivatives are disclosed herein. Also disclosed are methods for stabilizing a sunscreen composition by the addition of one or more of the foregoing derivatives, methods of filtering out ultra-violet light from a substrate by the use of one or more such derivatives, and methods for terminating a polymerization reaction by the addition of derivatives of diphenylmethylene and/or 9H-fluorene. Synergistic combinations of the polymer with (1) diesters or polyesters of a naphthalene dicarboxylic acid, or (2) oxybenzone enhance the photostability of sunscreen composition...
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COMPOSITIONS FOR INDUSTRIAL APPLICATIONS

(WO2004022601) 18.03.2004 C08K 3/34 J. Rettenmaier &Soehne GmbH + Co. KG
A composition has a particulate agglomerate of microcrystalline cellulose co-processed with additive materials, such as silicon dioxide, that are in intimate association with each other, the additive materials being integrated with or at least partially coating the microcrystalline cellulose. The additive materials are present in an amount of about 1 % to about 99 % by weight, based on the weight of the microcrystalline cellulose. When the material is silicon dioxide, the silicon dioxide is present in an amount of about 21 % to about 99 % by weight. A method of preparing a composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and additive materials; and drying the slurry ...
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PHOTOSTABILIZATION OF A SUNSCREEN COMPOSITION WITH AN ALPHA-CYANO-????, ????-DIPHENYLACRYLATE

(WO2004022021) 18.03.2004 A61K 8/35 CPH INNOVATIONS CORPORATION
Sunscreen compositions, including a mixture of a dibenzoylmethane derivative, and low and very low levels of an a-cyano-,-diphenylacrylate compound and, optionally, together with one or more diesters and polyesters of naphthalene dicarboxylic acid and a methoxy-substituted benzophenone.
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PERSONAL CARE COMPOSITIONS CONTAINING HIGHLY BRANCHED PRIMARY ALCOHOL COMPONENT

(WO2004022013) 18.03.2004 A61K 8/34 SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
A personal care composition for topical application to the skin or hair comprising (i) a branched primary alcohol component, having from 8 to 36 carbon atoms per molecule and an average number of branches per molecule of at least 0.7, preferably from 0.7 to 3.0, said branching preferably comprising methyl and/or ethyl branches, and said branched primary alcohol component optionally comprising up to 3 moles of alkylene oxide per mole of alcohol, or said branched primary alcohol component optionally comprising a product made by reacting alkylene oxide with branched primary alcohol in a ratio of up to 3 moles of alkylene oxide per mole of alcohol; and (ii) a cosmetically-acceptable vehicle. The personal care compositions of the invention provi...
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DEPIGMENTING COMPOSITION FOR THE SKIN COMPRISING ADAPALENE AND AT LEAST ONE DEPIGMENTING AGENT

(WO2004021967) 18.03.2004 A61K 8/67 GALDERMA RESEARCH &DEVELOPMENT, S.N.C.
The invention relates to a depigmenting composition for the skin comprising, in a physiologically acceptable medium, adapalene and at least one depigmenting agent and its pharmaceutical or cosmetic use.
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PHOTOSTABLE CATIONIC ORGANIC SUNSCREEN COMPOUNDS AND COMPOSITIONS OBTAINED THEREFROM

(WO2004020398) 11.03.2004 A61K 8/42 MERCK PATENT GMBH
Compounds of Formula (I) wherein R1 R1 and R2 are each independently hydrogen or linear or branched C1 to C10 alkyl, or linear or branched C1 to C10 alkoxy; R3 is selected from the group consisting of COCH3, CO2R7, CONH2, CON(R8)2, CN, COX(CH2)n-N-(R4)(R5)(R6), and the quaternized salt form of the formula COX(CH2)n-N-(R4)(R5)(R6)+Y-; X is O or NH; n is an integer of 1 to 5; Y is an anion; R4, R5 and R6 are independently linear or branched C1 to C30 alkyl; and R7 and R8 are independently hydrogen or linear or branched C1-C30 alkyl. Sunscreen formulations containing compounds of Formula (I), and methods for protecting hair, skin and substrates such as polymers, textiles, fabrics, leathers and paints using the compounds herein.
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SKIN LIGHTENING AGENTS COMPRISING COUMARIN DERIVED FROM RESORCINOL DERIVATIVES

(WO2004017936) 04.03.2004 A61K 8/42 UNILEVER PLC
Cosmetic methods of skin lightening using coumarin derivatives of formula (I) as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: where each or both R1 and/or R2 represents hydrogen, linear or branched C1-C18 alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups; each or both R3 and/or R4, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen, linear or branched C1-C18 alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; andeach or both R5 and/or R6 represents a hydrogen atom, OH, C1-C4 acyl group, C1-C4 alkyl group, O-CO-R7, O-COO-R8 group, mesyl group or tosyl ...
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SUNSCREENS

(WO2004007592) 22.01.2004 A61K 8/896 DSM IP ASSETS B.V.
Novel compounds, useful as sunscreens on the basis of polymethylsiloxanes comprising per molecule in arbitrary order 2-200 UV light absorbing chromophores, 2-200 lipophilic groups, optionally 1-100 groups able to form ionogenic or hydrogen bonds and optionally 1-20 elements of formula -O-SiH(CH3)- and compositions containing them.
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FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS

(WO2004007475) 22.01.2004 C07D 311/30 ROWETT RESEARCH INSTITUTE
Novel flavonoid compounds having anti-oxidant activity are described. Formula (1). The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion and injury, is described.
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AN HYDROXYTYROSOL-RICH COMPOSITION FROM OLIVE VEGETATION WATER AND METHOD OF USE THEREOF

(WO2004005228) 15.01.2004 A01N 31/16 CREAGRI, INC.
The invention provides olive-derived hydroxytyrosol. According to one aspect of the invention, vegetation water is collected from olives. Acid is added to stabilize the vegetation water and prevent fermentation. The mixture is incubated to allow oleuropein to convert to hydroxytyrosol, and then fractionated to separate hydroxytyrosol from other components. The hydroxytyrosol is useful as a therapeutic and anti-oxidant for a variety of health purposes, including for the treatment of skin damage. In addition, the hydroxytyrosol is useful as a natural anti-bacterial, anti-viral and fungicidal product for agricultural and pest control applications.
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COMPOSITIONS HAVING ENHANCED DEPOSITION OF A TOPICALLY ACTIVE ON A SURFACE

(WO2004004677) 15.01.2004 A01N 25/24 THE DIAL CORPORATION
Topically active compositions having enhanced effectiveness are disclosed. The compositions contain a topically active compound, an an-ionic surfactant, a hydric solvent, a hydrotrope, an optional cosurfactant, and water, wherein a percent saturation of the topical active compound of the composition is at least 25 %. The compositions exhibit a rapid and effective topical effect, and effectively deposit the topically active compound for an effective residual effect.
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TRANSDERMAL AEROSOL COMPOSITIONS

(WO2003000275) 31.12.2003 A61K 9/70 ACRUX DDS PTY LTD
The present invention provides a pharmaceutical composition for transdermal delivery comprising: one or more physiologically active agents; one or more dermal penetration enhancers; a pharmaceutically acceptable carrier comprising a volatile solvent; and a hydrofluorocarbon propellent; wherein the carrier and penetration enhancers combine to provide a single-phase solution of the one or more physiologically active agents.
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TOPICAL COSMETIC COMPOSITIONS

(WO2003000242) 31.12.2003 A61K 8/02 COSMECEUTIC SOLUTIONS PTY LTD
A topical cosmetic composition including: at least one water-soluble cosmetic agent; at least one oil-soluble cosmetic agent; and a dermal penetration enhancer; wherein topical application of the composition results in the delivery of the water-soluble and oil-soluble cosmetic agents into the stratum corneum as well as delivery of the oil-soluble cosmetic agent into the epidermis and dermis.
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DISPERSIONS OF A SOLID IN AN AQUEOUS LIQUID INCLUDING A POLYALKYLENEGLYCOL ESTER OR AMIDE OF A FATTY ACID DIMER AND/OR TRIMER

(WO2003106010) 24.12.2003 A01N 25/04 IMPERIAL CHEMICAL INDUSTRIES PLC
Polyethylene glycol esters and amides of polymerised fatty acids are useful dispersing agents for solids, particularly particulate solids e.g. agrochemicals, oil drilling mud components, pigments, personal care formulants, ceramics, magnetic materials, extenders, fillers, optical brighteners, textile auxiliaries, or soil removed from clothes during cleaning, in aqueous media. Particular such agents are of the formula (I): [Pol]-(COX)m (I), where: Pol is the core residue of a polymerised fatty acid; m is 2 or 3; and each X is: OM; where M is H, a cationic salt forming species or a group -(AO)n?R?7; or a group -NR?8-(AO)n?R?9; where AO is an alkylene oxide residue; n is from 1 to 100; and R?7, R?8 and R?9 are as defined, from ...
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STABILIZED RETINOL FOR COSMETIC DERMATOLOGICAL, AND PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF

(WO2003105806) 24.12.2003 A61K 31/07 SALVONA L.L.C.
The present invention relates to a controlled release system useful to stabilize retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. More specifically, the present invention pertains to stabilized retinol in a solid hydrophobic particle that sustains the release of retinol during the product shelf life and enables a gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients into biological surfaces.The present invention also refers to a process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. The invention ...
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SEBUM AND PERSPIRATION ABSORPTION FOUNDATION KIT AND ASSOCIATED MULTI-STEP METHOD

(WO2003105790) 24.12.2003 A61K 8/19 THE PROCTER &GAMBLE COMPANY
The present invention relates to a cosmetic kit suitable for application as a multi-step facial foundation product, said kit comprising: 1. a first composition that comprises: a. a safe and effective amount of an absorbent; and b. a first dermatologically acceptable carrier; and 2. a second composition that comprises: a. a safe and effective amount of one or more colorants; and b. a second dermatologically acceptable carrier wherein said second composition is topically applied to facial skin after said first composition.
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COSMETIC COMPOSITIONS COMPRISING AT LEAST ONE POLYSILOXANE BASED POLYAMIDE

(WO2003105789) 24.12.2003 A61K 8/88 L'OREAL
The invention relates to a physiologically acceptable composition, especially a cosmetic composition, comprising at least one volatile solvent and a liquid fatty phase comprising at least one structuring polymer, said structuring polymer (homopolymer or copolymer) having an average molecular weight of from 500 to 500,000 and comprising at least one moiety which comprises: at least one polyorganosiloxane group consisting of 1 to 1000 organosiloxane units in the chain of the moiety or in the form of graft, and at least two groups capable of establishing hydrogen interactions, the polymer being solid at room temperature and soluble in the liquid fatty phase at a temperature of from 25 to 250C.
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MULTI-STEP COSMETIC BENEFIT FOUNDATION KIT AND ASSOCIATED METHODS

(WO2003105787) 24.12.2003 A61K 8/06 THE PROCTER &GAMBLE COMPANY
The present invention relates to a cosmetic kit that is suitable for application as a multi-step facial foundation product wherein the kit comprises: 1) a first composition that comprises: a)a safe and effective amount of a first cosmetic benefit agent; and b) a first cosmetically acceptable carrier; and 2) a second composition that comprises: a) a safe and effective amount of one or more colorants having a refractive index greater than about 2.0; and b) a second cosmetically acceptable carrier; wherein said second composition is topically applied to facial skin after said first composition.
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SUNSCREEN COMPOSITIONS

(WO2003103615) 18.12.2003 C08F 20/06 SUN PHARMACEUTICALS CORPORATION
The present invention is directed to a cosmetic composition that has an amount of at least two rheology-modifying agents such that the viscosity of the composition remains stable over a broad temperature range. The compositions of the present invention may also include at least one of the following additional components: sunscreen agent, SPF booster, secondary emulsifier, emollient, moisturizer, humectant, film former/waterproofing agent, bio-active (functional) ingredient, pH adjuster/chelating agent, preservative, fragrance, effect pigment, color additive, or any combinations thereof.
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SUNSCREEN COSMETIC COMPOSITIONS STORAGE STABILIZED WITH MALONATE SALTS

(WO2003099250) 04.12.2003 A61K 8/02 UNILEVER PLC
A cosmetic composition is provided which includes an organic sunscreen agent and at least one salt of a malonic acid. The malonate salt inhibits discoloration which may arise from the presence of the sunscreen agent. Of particular concern in forming color bodies is 4,4'-t-butyl-methoxydibenzoylmethane.
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SUNSCREEN COMPOSITIONS AND CONTAINING AZOLIUM COMPOUNDS

(WO2003099249) 04.12.2003 A61K 8/49 ALTEON, INC.
Disclosed herein are novel methods for reducing or preventing the harmful effects of solar radiation on skin. Also disclosed are novel sunscreen compositions comprising thaizolium, thiadiazolium or triazolium compounds or derivatives and analogs thereof for reducing or preventing the harmful effects of solar radiation on skin. Sunscreen active agents that provide UV-A and UV-B filters are also included. The invention further discloses additional sunscreen active agents, emollients, humectants, dry-feel modifiers, waterproofing agents, insect repellants, antimicrobial preservatives, antioxidants, chelating agents, fragrances and moisturizers, suitable carriers for topical application and emulsions.
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SUNSCREEN COMPOSITIONS AND METHODS OF USE THEREOF

(WO2003099241) 04.12.2003 A61K 8/49 MANISCALCO, Tony
Disclosed herein are novel methods for reducing or preventing the harmful effects of solar radiation on skin. Also disclosed are novel sunscreen compositions comprising 3-[2-(4diethylaminophenyl)-2-oxoethyl]thiazolium salt for reducing or preventing the harmful effects of solar radiation on skin. Agents that provide UV-A and UV-B filters are also included. The invention further discloses additional sunscreen active agents, emollients, humectants, dry-feel modifiers, waterproofing agents, insect repellants, antimicrobial preservatives, antioxidants, chelating agents, fragrances and moisturizers, suitable carriers for topical application and emulsions.
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A COMPOSITION AND METHOD FOR INHIBITING POLAR CAPSULE DISCHARGE AND PROTECTING A SUBJECT FROM NEMATOCYST STING

(WO2003096993) 27.11.2003 A61K 8/19 NIDARIA TECHNOLOGY LTD.
The present invention provides compositions comprising at least one cation selected from the group consisting of Ga+3 and La+3, that effectively inhibit the discharge of nematocysts or polar capsules. The compositions described herein are effective at inhibiting nematocyst or polar capsule discharge when applied topically prior to exposure to nematocysts. The present invention further provides methods for inhibiting the discharge of nematocysts or polar capsules, comprising applying to the skin of a subject prior to contact with the nematocyst or polar capsule a compositions comprising at least one cation selected from the group consisting of Ga+3 and La+3. Thus, the present invention provides protection for swimmers, divers and fishermen, ...
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HYDROCARBON-TERMINATED POLYETHER-POLYAMIDE BLOCK COPOLYMERS AND USES THEREOF

(WO2003095524) 20.11.2003 A61K 8/86 ARIZONA CHEMICAL COMPANY
A block copolymer of the formula hydrocarbon-polyether-polyamide-polyether-hydrocarbon is described. The copolymer may be prepared by reacting together reactants that include dimer acid, diamine, and a polyether having both hydrocarbon termination and termination selected from one of amine, hydroxyl and carboxyl. The copolymer may be combined with a polar liquid to form a gel, where the gel may be transparent and may be incorporated into household and consumer products including antiperspirants. The copolymer may be formulated as a personal care product.
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A CATIONIC POLYMER COMPOSITION AND ITS USE IN CONDITIONING APPLICATIONS

(WO2003095497) 20.11.2003 A61K 8/73 HERCULES INCORPORATED
A composition of a cationic polygalactomannan or a derivative of cationic polygalactomannans is provided that has a mean average molecular weight (Mw) having a lower limit of 5,000 and an upper limit of 200,000 and has a light transmittance in a 10% aqueous solution of greater than 80% at a light wavelength of 600 nm and a protein content of less than 1.0% by weight of polysaccharide, and aldehyde functionality content of at least of 0.01 meq/gram. This composition is prepared in continuous or batch processes using either oxidizing reagents or combination of hydrolytic reagents and oxidizing reagents. This composition is used in personal care and household care products.
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PERSONAL CARE COMPOSITIONS COMPRISING A DICARBOXY FUNCTIONALIZED POLYORGANOSILOXANE

(WO2003094871) 20.11.2003 A61K 8/896 THE PROCTER &GAMBLE COMPANY
Disclosed are personal care or cosmetic compositions comprising a dicarboxy functionalized polyorganosiloxane and methods for the cleaning or the treatment of hair or skin and for enhancing delivery of active agents to hair or skin with the compositions. Said personal care or cosmetic compositions can be formulated in a wide variety of types of products for the skin and/or hair (or, more generally, keratin) such as mousses, gels (in particular hair dressing gels), conditioners, hair dressing formulations or to aid comb-through of hair, rinsing formulae, hand and body lotions, skin moisturising products, skin cleansing or disinfecting compositions, shower gels, toilet milks, cream foundations, make-up removal compositions, sun and ultraviole...
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COMPOSITION FOR A CLEAR COSMETIC STICK

(WO2003092431) 13.11.2003 A61K 8/34 COTY INC.
The present invention includes a clear cosmetic stick that has a clarity that is stable over a temperature of 5 to 45 degrees Centigrade for a time period of at least about twelve months. The clear cosmetic stick includes one or more of a branched chain fatty acid surfactant and a straight-chain fatty alcohol surfactant.
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PERSONAL CARE ARTICLE WITH DISTINCT ACTIVE ZONE

(WO2003090709) 06.11.2003 A61K 8/02 UNILEVER PLC
A disposable, single-use, personal care article is disclosed having an active zone, an adjacent non-active zone, and interface therebetween; a benefit agent releasably associated with the active zone; a carrier solvent and optionally a visual indicator associated with the active zone. In one embodiment, the benefit agent, the carrier solvent, and a dye indicator are combined and applied as stripes on the article. The stripes will not substantially bleed into the adjacent non-active zone and will disappear during use of the article indicating that the benefit agent has been transferred to the skin or hair of the user.
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EMOLLIENT PARTICLES, SUNSCREEN COMPOSITIONS AND METHODS OF MANUFACTURE THEREOF

(WO2003090698) 06.11.2003 A61K 8/04 INTERNATIONAL FLORA TECHNOLOGIES LTD.
Compositions consisting of emollient particles that carry at least one of active sunscreen material, self-tanning material and visual effects material, and transparent and translucent topical sunscreen preparations having disposed therein such emollient particles.
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UREA COMPOSITIONS

(WO2003086291) 23.10.2003 A61K 8/365 YU, Ruey, J.
The invention is directed to compositions, methods of making the compositions, and methods of treating cosmetic and dermatological disorders with a composition that includes a molecular complex between urea and a functional substance that has at least one hydroxyl group and one carboxyl group either as a free acid, a salt, an amide or a lactone. The compositions are stable when compared to conventional urea-containing compositions, and provide controlled-release of the urea.
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PHOTOSTABLE CATIONIC ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPISITIONS OBTAINED THEREFROM

(WO2003084920) 16.10.2003 A61K 8/42 MERCK PATENT GMBH
Compounds of Formula (I) F Each R is independtly linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy; R1 is selected from the group consisting of COCH3,CO2R3, CONH2, COHR(R4)2, CN, COX(CH2)n-N-(R2)(R4)(R3), and the quaternized salt form of the formula COX(CH2)-N-n-(R2)(R4)(R3)+-Y; X is O or NH; n is an integer of 1 to 5; Y is an anion; and R2, R3 and R4 are independently lilnear or branched C1 to C20. Hair care formulations and other compounds containing compounds of Formula (I), and methods for protecting hair and substrates such as polymers, textiles, fabrics, leathers and paints the compounds herein.
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LIGHT-PROTECTIVE PREPARATIONS CONTAINING A PHOTOSTABLE UV-A FILTER

(WO2003084496) 16.10.2003 A61K 8/35 SYMRISE GMBH &CO. KG
The invention relates to photostable cosmetic or dermatological light-protective preparations containing at least one lipid phase and at least one aqueous phase, characterized by the fact that said preparations contain a) at least one UV-A sun screen based on dibenzoylmethane derivatives, b) at least one monosulfonated or polysulfonated UV-A sun screen that is water-soluble as salt, and c) at least one naphthalene dicarboxylic acid derivative. Also disclosed is a method for stabilizing dibenzoylmethane derivatives and the use of the light-protective preparations for protecting the skin and hair from UV rays.
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TOPICAL USE OF VITAMIN B6 COMPOSITIONS

(WO2003082230) 09.10.2003 A61K 8/64 THE PROCTER &GAMBLE COMPANY
The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a vitamin B6 compound selected from the group consisting of pyridoxine, esters of pyridoxine, amines of pyridoxine, salts of pyridoxine and derivatives thereof, including pyridoxamine, pyridoxal, pyridoxal phosphate, and pyridoxic acid; b) a safe and effective amount of a skin care active selected from the group consisting of peptides, phytosterol, sugar amines, their derivatives, and combinations thereof; and c) a der...
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STABILIZATION OF SUNSCREENS IN COSMETIC COMPOSITIONS

(WO2003080009) 02.10.2003 A61K 8/34 UNILEVER PLC
Cosmetic compositions containing organic sunscreens along with a 4-substituted resorcinol derivatives of general formula I exhibit improved storage stability and oxidative stability, where each R1 and R2, independently, represents a hydrogen atom, -CO-R (acyl group), -COO-R, CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C1 - C18 hydrocarbon groups; and R3 represents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., R3 constitutes linear or branched chain alkyls, or (2) a group of the general formula (II), where X is preferably H, n is 0 to 3 a...
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PERSONAL CARE COMPOSITIONS COMPRISING SOLID PARTICLES ENTRAPPED IN A GEL NETWORK

(WO2003080005) 02.10.2003 A61K 8/04 THE PROCTER &GAMBLE COMPANY
The present invention relates to a personal care composition comprising a three dimensional gel polymeric network comprising: a. a polymer; b. one or more solid particles that are entrapped within said polymer during polymerization of said polymer; and c. a solvent in which said polymer is dispersed. Another embodiment further includes at least one second colorant that is substantially similar to an at least one first colorant which is a solid particle and wherein said second colorant is dispersed within said composition but is not entrapped in said polymer and is separate and distinct from said network. In contrast, a third embodiment allows for the at least one second colorant to be substantially different from the at least one first colo...
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STABILIZATION OF RESORCINOL DERIVATIVES IN COSMETIC COMPOSITIONS

(WO2003080002) 02.10.2003 A61K 8/19 UNILEVER PLC
Cosmetic compositions containing a micronized metal oxide along with a 4-substituted resorcinol derivatives of the general formula I exhibit improved storage stability: (I) where each R1? and R2?, independently, represents a hydrogen atom, -CO-R (acyl group), -COO-R, CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C1? - C18? hydrocarbon groups; and R3? represents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., R3? constitutes linear or branched chain alkyls, or (2) a group of the general formula (II) wherein X is preferably H, n is...
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MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

(WO2003076424) 18.09.2003 A61K 31/335 EISAI CO. LTD.
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.
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COSMETIC COMPOSITIONS COMPRISING CITRIC ACID TRIESTERS

(WO2003075880) 18.09.2003 A61K 8/37 UNILEVER PLC
A skin care cosmetic composition comprising: (a) an amount from 0.01 to 20% by weight of one or more esters of citric acid having the structure (1): where R1 is chosen from one of tri-secondarybutyl citrate, tri-isopropyl citrate, tri lauroyl citrate or their mixtures thereof; and (b) from 10 to 99.9% by weight of an acceptable vehicle for the citric acid.
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A PROCESS FOR PREPARING A COSMETIC FORMULATION AND A COMPOSITION THEREFOR

(WO2003075879) 18.09.2003 A61K 8/02 DOW GLOBAL TECHNOLOGIES INC.
The present invention includes a process of preparing an advanced cosmetic product by combining a high internal phase ratio (HIPR) emollient-in-water emulsion with a partial cosmetic formulation that typically contains water, a coloring agent, a fragrance, a rheology modifier, or a pH adjuster, or a combination thereof. The present invention also includes compositions directed to two particular subclasses of HIPR emollient-in-water emulsions, namely an HIPR silicone elastomer-in-water emulsion and an HIPR sunscreen-in-water emulsion and water-diluted dispersions thereof. The use of an HIPR emulsion of a cosmetic emollient provides a simple and flexible method of formulating the cosmetic product, due in part to the long shelf-stability of th...
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METHODS OF MAKING AND SELLING A SUNSCREEN COMPOSITION

(WO2003075878) 18.09.2003 A61K 8/35 THE C.P. HALL COMPANY

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NEW COMPOSITION INCLUDING A PIGMENT ASSEMBLY COMPRISING A MICA CORE

(WO2003075876) 18.09.2003 A61K 8/26 OVE KARLSSON KONSULT
The present invention relates to a composition including a pigment assembly comprising a mica core, wherein said composition is intended to be applied on the skin on a mammal in need thereof for the prevention of skin damages caused by exposure to ultraviolet radiation.
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CONTROLLED DELIVERY PATCH OF ACTIVE INGREDIENT

(WO2003075812) 18.09.2003 A61K 8/02 SALVONA L.L.C.
The present invention relates to a patch for controlled topical or transdermal delivery of effective levels of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin, hair follicles, and sebaceous glands, with minimal discomfort and ease of use. The patch can be transparent or clear and comprises a rate-controlling polymeric matrix layer. The polymeric matrix layer comprises water-soluble, bioadhesive, film forming polymers. The cosmetic, dermatological, and pharmaceutical active ingredients are soluble or dispersed in the polymeric matrix. The patch becomes tacky when wetted and adheres onto the skin. The adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended tr...
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A SUBSTANTIALLY VISIBLY TRANSPARENT TOPICAL PHYSICAL SUNSCREEN FORMULATION

(WO2003072077) 04.09.2003 A61K 8/06 ADVANCED POWDER TECHNOLOGY PTY LTD
A topically applied sunscreen composition is provided, which by use of nano-sized particles of a physical UV screening agent in a dermatologically acceptable carrier, provides a dermatologically acceptable level of SPF and broad-spectrum protection from UVA and UVB radiation without the need to include chemical UV screening agents in the composition.
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TOPICAL DAPSONE FOR THE TREATMENT OF ACNE

(WO2003072071) 04.09.2003 A61K 8/46 ATRIX LABORATORIES, INC.
The present invention relates to a method of treating acne by topically applying a dermatological composition comprising dapsone. In addition to inflammatory lesions, the compositions also treats non-inflammatory acne. The composition is formulated to include dapsone in a both a dissolved and microparticulate state.
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ENCAPSULATION PROCESS AND ENCAPSULATED COMPOSITIONS

(WO2003066209) 14.08.2003 A61K 8/35 DOW CORNING CORPORATION
A lipophilic cosmetic, chemical, biological or pharmaceutical active material composition encapsulated within a shell of the emulsion polymerisation product of a tetraalkoxysilane. A water reactive silicon compound comprising tetraalkoxysilane is added to an aqueous emulsion of the active material composition having a positive zeta-potential, whereby the tetraalkoxysilane condenses and polymerises at the interface of the emulsified droplets of the lipophilic active material composition to form microcapsules having a core of the active material composition surrounded by a shell of silicon-based network polymer.
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DRUG NANOPARTICLES WITH LYSOZYME SURFACE STABILISER

(WO2003066021) 14.08.2003 A61K 9/14 ELAN PHARMA INTERNATIONAL, LTD.
The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.
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MIXTURES OF QUATERNARY COMPOUNDS

(WO2003060046) 24.07.2003 A61K 8/41 CRODA, INC.
Compositions that include mixtures of (a) at least one dialkyl quat in the amount of from about 10% to about 90% by weight of the composition; and (b) at least one monoalkyl quat in the amount of from about 10% to about 90% by weight of the composition are provided. Various embodiments are provided. In one embodiment, the mixtures include dialkyl immidazoline quats and monoalkyl ammonium quats. Various methods of making immidazoline quats and quat mixtures, personal care and cosmetic products and formulations that contain the immidazoline quats and quat mixtures, methods of making such personal care and cosmetic products and formulations, and methods of using the such immidazoline quats, quat mixtures, and personal care and cosmetic pr...
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SKIN-LIGHTENING COMPOSITION

(WO2003059313) 24.07.2003 A61K 8/97 MERCK PATENT GMBH
A light colored standardized extract of Emblica officinalis consisting essentially of over 40% by weight of Emblicanin A. Emblicanin B, Pedunculagin and Punigluconin, and not more than about 1% by weight of flavonoids, and methods of producing same. Also disclosed are cosmetic or pharmaceutical compositions comprising the standardized extract and methods of using same to lighten or whiten skin.
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METHOD FOR THE APPLICATION OF A VISCOUS COMPOSITION TO THE SURFACE OF A PAPER WEB AND THEIR PRODUCTS

(WO2003057988) 17.07.2003 D21H 23/50 KIMBERLY-CLARK WORLDWIDE, INC.
A method is disclosed for topical application of compositions containing a chemical additive onto a paper web. The present invention is also directed to paper products formed from the method. In general, the method includes the steps of extruding a composition containing a chemical additive through a meltblown die and then applying the composition to a moving paper web. In one embodiment, the chemical composition is extruded into fibers and applied to the paper web. The chemical composition can contain, for instance, various additives, such as a polysiloxane softener.
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STABLE SURFACTANT COMPOSITIONS FOR SUSPENDING COMPONENTS

(WO2003055456) 10.07.2003 A61K 8/04 RHODIA INC.
A free-flowing surfactant composition comprising at least one anionic surface-active agent, an alkanolamide, an electrolyte, and water is described. In particular, the composition is a surfactant composition that has free-flowing non-Newtonian shear thinning properties and the ability to suspend components and is stable under at least one freeze/thaw cycle.
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RESVERATROL ANALOGUES

(WO2003055444) 10.07.2003 A61K 8/33 AVON PRODUCTS, INC.
A method for treating the skin of a human is disclosed. Also disclosed is a composition for carrying out such method, in which the composition has at least one resveratrol analogue represented by the formula (I), wherein each X1 and X2 are not both hydrogen but each X1 and X2 are otherwise independently selected from the group consisting of hydrogen, hydroxy, alkoxy, acyl and carboxyl; wherein each X3 is selected from the group consisting of hydrogen, hydroxy, alkoxy and acyl; wherein each Y1 is selected from the group consisting of carbohydrate, hydrogen and hydroxyl; wherein R1 and R2 are double-bonded in cis or trans configuration and each R1 and R2 are independently selected from the group consisting of hydrogen, alkoxy, carboxyl, metho...
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TREATMENT OF FABRIC ARTICLES WITH SPECIFIC FABRIC CARE ACTIVES

(WO2003054281) 03.07.2003 C11D 3/20 THE PROCTER &GAMBLE COMPANY
Methods and compositions to treat fabrics with lipophilic fluid and a specific fabric care active are provided by the present invention.
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SUNSCREEN COMPOSITION COMPRISING CHLORPHENESIN

(WO2003053392) 03.07.2003 A61K 8/34 SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.
Described is a method for preparing sunscreening compositions that contain chlorphenesin as a biocidal preservative, wherein the chlorphenesin is dissolved in water-insoluble components.
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PHOTOSTABLE SUNSCREEN COMPOSITIONS AND METHODS OF STBAILIZING

(WO2003051318) 26.06.2003 A61K 8/35 AVON PRODUCTS, INC.
There is provided a photostable and synergistically enhanced topical sunscreen composition. There is further provided a method of enhancing the photostability of a sunscreen active in a topical sunscreen composition. There is further still provided a method of synergistically enhancing the UV absorbance of a sunscreen active in a topical sunscreen composition. The preferred compositions and methods of the present invention use a dibenzoylmethane sunscreen active, a Kaempferia galanga extract, and a cosmetically acceptable vehicle.
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TOPICAL COMPOSITIONS AND METHODS OF APPLICATION

(WO2003051279) 26.06.2003 A61K 8/37 AVON PRODUCTS, INC.
There are topical emulsion compositions having a cosmetic drug or medicinal active, a novel compound of the present invention, and a vehicle. The novel compound is represented by a formula selected from the group consisting of L-A-H and A-L-H, wherein L is a lipophilic moiety, A is an aromatic moiety, and H is a hydrophilic moiety. Also provided are methods of emulsifying a composition; improving the photostability of a composition; and enhancing the effectiveness of a sunscreen composition.
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CLEANING ARTICLE CONTAINING HYDROPHILIC POLYMERS

(WO2003049939) 19.06.2003 A61K 8/02 REGENESIS, LLC
The invention relates to a cloth that can function as a moisturising cleanser. When the cloth is moistened with water, it works up into a warm, sudsy cleansing lotion that feels great and works well as a facial cleansing cloth. The cloth contains water, at least one surfactant and at least one hydrophilic polymer.
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METHODS FOR THE TREATMENT OF HYPERPIGMENTATION OF SKIN

(WO2003047543) 12.06.2003 A61K 8/19 PROCYTE CORPORATION
Methods for treating hyperpigmentation of skin employ topical application of compositions to skin in need thereof, where the compositions comprise at least one peptide copper complex, or at least one peptide copper complex in combination with retinol, at least one retinol derivative, or a mixture thereof. Also disclosed are methods that use such compositions further comprising active agents selected from active drug substances, emollients, sunscreen agents, skin-lightening agents, skin protectants, skin conditioning agents, and humectants.
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COMPOSITIONS COMPRISING PHENYL-GLYCINE DERIVATIVES

(WO2003045338) 05.06.2003 A61K 8/44 YU, Ruey, J.
The invention relates to compositions and methods useful for treating a variety of cosmetic conditions and dermatological disorders, where the composition includes a phenyl glycine derivative represented by the following formula&colon (I); wherein, R1 and R2 are independently H, I, F, Cl, Br, OH, SH, NH2, NHNH2 alkyl, aralkyl, alkoxy, acetoxy, acyloxy group having 1 to 9 carbon atoms, and being attached at the 2, 3 or 4 position of the phenyl group, whereby when R1 and/or R2 are OH, SH, NH2, they may be acetylated or acylated with 1 to 9 carbon atoms; R3 is H, formyl, acetyl, propanoyl, acyl, alkyl, aralkyl or an aryl group having 1 to 9 carbon atoms; R4 is OH, NH2 NHOH, NHNH2, or OR; where R is an alkyl, aralkyl or aryl ...
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METAL OXIDE COMPOSITION

(WO2003041677) 22.05.2003 A61K 8/04 IMPERIAL CHEMICAL INDUSTRIES PLC
A composition comprises a non-ionic surfactant and hydrophobic particles of metal oxide having the mean length of the primary particles in the range from 50 to 90 nm, the mean width of the primary particles in the range from 5 to 20 nm, and the median volume particle diameter of the secondary particles is less than 45 nm. The composition is particularly suitable for use in aqueous media, and can be used in a sunscreen product that exhibits both effective UV protection and improved transparency.
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METHOD AND DEVICE FOR HUMAN SKIN TANNING WITH REDUCED SKIN DAMAGE

(WO2003039671) 15.05.2003 A61N 5/06 REGENTS OF THE UNIVERSITY OF MICHIGAN
Tanning can be effected much more safely if radiation limited to the range between 330 nm and 360 nm is used for tanning human skin. Other wavelenghts, which may tend to induce MMPs, promote erythema, and/or cause DNA damage.
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COMPOSITIONS CONTAINING OILS HAVING A SPECIFIC GRAVITY HIGHER THAN THE SPECIFIC GRAVITY OF WATER

(WO2003039510) 15.05.2003 A61K 8/11 SOL-GEL TECHNOLOGIES LTD.
The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.
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SILICONE ELASTOMER EMULSION COSMETIC COMPOSITION COMPRISING COLORANT INCLUSIVE INTERNAL PHASE

(WO2003035016) 01.05.2003 A61K 8/89 THE PROCTER &GAMBLE COMPANY
The present invention relates to silicone elastomer emulsion cosmetic compositions that comprise an internal phase that further includes a colorant. These compositions are intended to deliver such colorant ingredients to the skin of the user in such a manner as to provide a smooth and even colored appearance. In particular, the present invention relates to a cosmetic composition comprising an emulsion that further comprises: a) a continuous aqueous phase comprising:1) from about 0.1% to about 10%, by weight of the composition, of a non-emulsifying crosslinked siloxane elastomer;b) a dispersed oil phase comprising: 1) from about 1% to about 25%, by weight of the composition, of an oil compatible colorant; an...
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NANOPARTICULATE COMPOSITIONS COMPRISING INORGANIC CORES

(WO2003032959) 24.04.2003 A61K 9/14 BOSCH, William, H.
The invention is directed to nanoparticulate compositions comprising inorganic cores and methods of making and using such compositions. The nonoparticulate compositions comprise at least one type of organic core having adsorbed or bound to the surface thereof at least one type of active molecule. The compositions exhibit superior properties as compared to conventional micronized and nanoparticulate active agent formulations.
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ESTERS OF AROMATIC ALKOXYLATED ALCOHOLS AND FATTY CARBOXYLIC ACIDS

(WO2003032919) 24.04.2003 A61K 8/39 CRODA, INC.
Esters of alkoxylated aromatic alcohol and fatty carboxylic acid are provided. The esters are especially suitable as additives for personal care and cosmetic products. Certain of the esters of alkoxylated aromatic alcohol and fatty carboxylic acid having certain skin spread factor or viscosity are also provided. A personal care or cosmetic product composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional ingredients in the composition 15 may include active ingredients and additional ingredients. Especially suitable active ingredients are sunscreen active ingredients and an...
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SKIN CARE COMPOSITIONS CONTAINING PEPTIDE COPPER COMPLEXES AND RETINOL, RETINOL DERIVATIVES, OR A MIXTURE THEREOF

(WO2003030860) 17.04.2003 A61K 8/19 PROCYTE CORPORATION
Compositions, generally useful for preserving the skin and/or improving its health and appearance, comprise a peptide copper complex and retinol, a retinol derivative, or a mixture thereof. In another embodiment, the disclosed compositions further comprise additives, including emollients, sunscreen agents, skin protectants, skin conditioning agents, and/or humectants. Also disclosed is a method for treating skin to accomplish such preservation and/or improvement thereof, where the method comprises the step of topically applying a disclosed composition to an area of skin in need of such treatment.
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FABRIC ARTICLE TREATING SYSTEM

(WO2003029551) 10.04.2003 D06F 73/02 THE PROCTER &GAMBLE COMPANY
A fabric article treating system, and more particularly to a fabric article treating system comprising at least a fabric article active delivery stage and a fabric article transporter capable of passing a fabric article in need of treatment through the fabric article active delivery stage such that a fabric article active is delivered to the fabric article is provided. Methods of treating fabric articles, especially with the fabric article treating system is also provided.
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METHOD AND TOPICAL FORMULATION FOR TREATING SKIN CONDITIONS ASSOCIATED WITH AGING

(WO2003026680) 03.04.2003 A61K 8/19 DERMATRENDS, INC.
A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation provides a pH in the range of about 8.0 to 13.0 at the skin surface, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either an inorganic base, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid,...
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SUNSCREEN COMPOSITIONS

(WO2003026595) 03.04.2003 A61K 8/27 PLAYTEX PRODUCTS, INC.
The present invention is a sunscreen composition that has at least one sunscreen agent and at least one glucoside emulsifier, The composition also has water. Preferably, the sunscreen composition also has at least one of the following additional components: emulsifier other than glucoside, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof. The composition is a stable oil-in-water emulsion.
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FABRIC TREATMENT COMPOSITION AND METHOD

(WO2003025108) 27.03.2003 C11D 3/16 THE PROCTER &GAMBLE COMPANY
Compositions and methods for wrinkle reduction in fabrics, including washable clothes, dry cleanable clothes, linens, bed clothes, draperies, window curtains, shower curtains, table linens, and the like requiring little, if any, pressing, ironing, and/or steaming are disclosed. The compositions contain an effective amount of a polymer for controlling wrinkles in a fabric, a co-solvent and a carrier.
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MONOCARBOXYLIC ACID ESTERS OF PROPOXYLATED FATTY ALCOHOLS AS PIGMENT DISPERSANTS

(WO2003024416) 27.03.2003 A61K 8/27 INNOVACHEM, INC.
A novel fatty polypropoxylate ester which is an ester of an aliphatic or an aromatic monoacid formed by reacting the acid with a stoichiometric excess of a polypropoxylated fatty alcohol. The compounds have the following structural formula (I), wherein R1? is a polypropoxylated fatty alcohol having the structural formula (II), wherein R5? is a saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic moiety containing from 4 to 24 carbon atoms, and x is an integer from 3 to 30; and wherein R has the structural formula (III) a) wherein R2?, R3?, and R4? are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl; or b) Formula (IV), wherein R6? is H or OH or NH2? or methyl or et...
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COSMETIC COMPOSITION WITH ORGANIC SUNSCREEN AND POROUS POWDER PARTICLES

(WO2003022234) 20.03.2003 A61K 8/04 UNILEVER PLC
A cosmetic composition is provided which includes an organic sunscreen agent, a water-insoluble polymeric powder of porous particles, and an aqueous system wherein pH is less than 7. The porous particles remove the tackiness normally associated with organic sunscreen agents and low pH systems thereby providing a resultant composition of excellent skinfeel and preferably is made of methacrylate crosspolymer.
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FLUORESCENT NATURAL DYE FROM A MARINE ORGANISM

(WO2003020832) 13.03.2003 C09B 61/00 COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
The present invention provides a novel compound multiple fluorescent natural dye from a marine organism Holothuria Scabra having a chemical structure of Si-O-R type wherein silica matrix is an integral part of the compound, taking part in the metabolism of the animal, wherein R being an organic moiety and also provides a composition containing the compound having various applications; also a process of extraction, purification and characterization of the novel multiple fluorescent natural dye compound from a marine organism (Holothuria Scabra).
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SUNSCREEN COMPOSITION

(WO2003015727) 27.02.2003 A61K 7/02 THE PROCTER &GAMBLE COMPANY
Disclosed is a water-in-oil emulsified sunscreen composition comprising by weight: (a) an effective amount of a UV protection agent; (b) from about 0.1 % to about 70 % of a non-thickening oil absorbing powder having a mineral oil absorbing ability of at least about 40ml/100g; (c) at least about 10 % of the entire composition of water; and (d) an oil phase comprising: (i) at least about 50 % by weight of the oil phase of a volatile silicone oil; and (ii) from about 0.1 % to less than the oil absorbing ability of the non-thickening oil absorbing powder of a non-volatile oil; wherein when the UV protection agent is a non-volatile liquid of hydrophobic nature, it is considered the non-volatile oil.
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SUNSCREEN COMPOSITION

(WO2003015726) 27.02.2003 A61K 7/02 THE PROCTER &GAMBLE COMPANY
Disclosed is a water-in-oil emulsified sunscreen composition comprising by weight:(a) an effective amount of a UV protection agent; (b) from about 0.1% to about 70% of a non-thickening oil absorbing powder having a mineral oil absorbing ability of at least about 40ml /100g;(c) at least about 10% of the entire composition of water; and(d) an oil phase comprising:(i) at least about 50% by weight of the oil phase of a volatile silicone oil; and(ii) from about 0.1% to less than the oil absorbing ability of the non-thickening oil absorbing powder of a non-volatile oil; wherein when the UV protection agent is a non-volatile liquid of hydrophobic nature, it is considered the non-volatile oil.
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AQUEOUS COMPOSITIONS FOR USE IN SURFACE PROTECTION COMPRISING POLYMER WITH HYDROPHOBIC AND HYDROPHILIC CONSTITUENTS

(WO2003011969) 13.02.2003 A61K 8/86 NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION
The present invention is directed to an aqueous polymer composition comprising a copolymer and water, the copolymer containing at least one hydrophilic base or acid-neutralizable monomer and at least one hydrophobic ethylenically unsaturated monomer. A film formed from the contains essentially no crosslinking. The polymer composition is formed by polymerizing the hydrophilic monomer and hydrophobic monomer in a non-aqueous solvent; forming an aqueous polymer dispersion from the non-aqueous polymer solution, and adding a base or acid to form an aqueous polymer composition.
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SILYLATED POLYURETHANE-UREA COMPOSITIONS FOR USE IN COSMETIC APPLICATIONS

(WO2003011937) 13.02.2003 C08G 18/08 3M INNOVATIVE PROPERTIES COMPANY
A composition in the form of an aqueous dispersion used in cosmetic applications is provided. The composition comprises at least one polyurethane-urea polymer that is functionalized with at least one hydrolyzed or hydrolyzable silyl group. When the composition is used in hair care, it does not have a reshapable effect.
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SUNSCREEN COMPOSITION

(WO2003011239) 13.02.2003 A61K 8/11 MERCK PATENT GMBH
The present invention relates to a composition having UV protection properties, charaterized in that the formulation comprises at least one encapsulated organic sunscreen and does not penetrate the skin essentially.
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SUNSCREEN COMPOSITION

(WO2003011238) 13.02.2003 A61K 8/04 MERCK PATENT GMBH
The present invention relates to a foamable aqueous composition having UV protection properties comprising at least one hydrophobic organic sunscreen agent and at least one foam builder / stabiliser.
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PHOTOSTABLE ORGANIC SUNSCREEN COMPOUNDS WITH ANTIOXIDANT PROPERTIES AND COMPOSITIONS OBTAINED THEREFROM

(WO2003007906) 30.01.2003 A61K 8/37 MERCK PATENT GMBH
A compound of formula (I) wherein A is a moiety which provides UV absorbing activity to the compound of formula (I) that comprises 2 monovalent groups having carbonyl (C=O) functionality. R?6 is linear or branched C1?-C8? alkyl and R?5 is a linear or branched C1?-C8?alkyl or hydrogen or linear or branched O-C1-8?alkyl. Sunscreen formulations which contain these compounds and methods for using these compounds to prepare formulations are also provided.
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COMPOSITIONS FOR REDUCING OR PREVENTING CELLULITE IN MAMMALIAN SKIN

(WO2003006009) 23.01.2003 A61K 31/20 ZEN-BIO, INC.
Compositions and methods for preventing and/or treating cellulite in mammalian skin characterized by a subcutaneous accumulation of adipose tissue are provided. The skin care composition comprises conjugate linoleic acid (CLA), an AZOLE antifungal agent and a pharmaceutically acceptable carrier. In a particular embodiment, the composition comprises effective amounts of 10-trans, 12-cis conjugated linoleic acid, ketoconazole and a dermatologically acceptable carrier. Prevention and/or treatment is accomplished by topically applying a composition comprising safe and effective amounts of conjugated linoleic acid in combination with an imidazole antifungal agent. The compositions of the invention improve dermal appearance by promoting lipolysis...
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COMPOSITION COMPRISING SULFACETAMIDE AND A SUNSCREEN FOR THE TREATMENT OF ROSACEA

(WO2003006005) 23.01.2003 A61K 31/16 STIEFEL LABORATORIES, INC.
The present invention provides improved sulfacetamide and sulfur formulations including sunscreens for the treatment of rosacea.
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CANCER TREATMENT METHOD AND COMPOSITIONS COMPRISING COMPOUNDS OF THE GINGER FAMILY

(WO2002098399) 12.12.2002 A61K 31/121 REGENTS OF THE UNIVERSITY OF MINNESOTA
The present invention provides pharmaceutical compositions including: a combination of a compound of the formula (I) wherein R?1 is C1?-C6? alkyl and R?2 is independently -H or -OH, or a pharmaceutically acceptable salt thereof; and a phorbol compound. The present invention also provides for these and other compositions and their use for the treatment of established cancers or tumors.
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SKIN-PERMEABLE COMPOSITION COMPRISING A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR A MONOHYDRIC ALCOHOL

(WO2002096435) 05.12.2002 A61K 31/122 PHARMACIA CORPORATION
A dermally deliverable pharmaceutical composition comprises at least one selective cyclooxygenase-2 (COX-2) inhibitory drug or prodrug thereof solubilized in a pharmaceutically acceptable carrier that comprises a low molecular weight monohydric alcohol, and exhibits a skin permeation rate of the therapeutic agent at least equal to that exhibited by a reference solution of the therapeutic agent in 70% aqueous ethanol. A method of effecting targeted delivery of a selective COX-2 inhibitory drug to a site of pain and/or inflammation in a subject comprises topically administering such a composition to skin of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation. A method of effecting systemic treatmen...
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TOPICAL COSMETIC COMPOSITION COMPRISING AN ALPHA-BETA-UNSATURATED ESTER AS BONDING AGENT

(WO2002096373) 05.12.2002 A61K 8/31 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise a safe and effective amount of a aldehyde or ketonea Schiffs base bonding agent comprising the structure wherein X represents a cosmetic benefit agent; L represents an optional chemical linker; andeither tethered to a chemical linker or no R represents a hydrocarbon chain that optionally contains heteroatoms; and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to a mammalian proteinaceous substrate and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent is covalently attached to the substrate. The invention further relates to methods of using the compositions descri...
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TOPICAL COMPOSITION COMPRISING AN ACTIVATED, TRANS-STRUCTURED COSMETIC BONDING AGENT

(WO2002096372) 05.12.2002 A61K 8/31 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising trans structure wherein X represents a cosmetic benefit agent, L represents an optional chemical linker between X and a remainder of the bonding agent; and either tethered to a chemical linker or not R represents an activating electron withdrawing group; and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to m...
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DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS

(WO2002095393) 28.11.2002 C07B 61/00 NATIONAL RESEARCH COUNCIL OF CANADA
A new method of designing and generating compounds having an increased probability of being drugs, drug candidates, or biologically active compounds, in particular having a therapeutic utility, is disclosed. The method consists of identifying a group of bioactive compounds, preferably of diverse therapeutic uses or biological activities and built on a common building block. In this group of compounds, side chains modifying the building block are identified and used to generate a second set of compounds according to the proposed methods of 'hybridization', 'single substitution' or 'incorporation of frequently used side chains'. If the compounds in the second set built on the same building block contain an unusually large number of drugs, pre...
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SYSTEM FOR DELIVERING COSMETICS AND PHARMACEUTICALS

(WO2002092049) 21.11.2002 A61K 8/02 3M INNOVATIVE PROPERTIES COMPANY
A novel device for the delivery of one or more active agents to a subject is disclosed. The device includes a water-soluble or water-dispersible polymeric carrier, an adhesive, one or more active agents and a support layer. Methods of manufacturing and use of said device also are disclosed.
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COSMETIC COMPOSITIONS USING POLYETHER SILOXANE COPOLYMER NETWORK COMPOSITIONS

(WO2002092048) 21.11.2002 A61K 8/02 GENERAL ELECTRIC COMPANY
A composition comprising the reaction products of MaMHbMEcDdDHeDEfTgTHhTEiQj where M=R1R2R3SiO1/2; MH=R4R5H SiO1/2; ME=R6R7RESiO1/2; D=R8R9SiO2/2; DH=R10HsiO2/2; DE=R11RESiO2/2; T=R12SiO3/2; TH=HsiO3/2; TE=RESiO3/2; and Q=SiO4/2; where the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound.
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TOPICAL PRODUCT WITH VISUAL INDICATOR

(WO2002092040) 21.11.2002 A45D 40/16 THE GILLETTE COMPANY
A product for application to the skin includes a container and a composition within the container including a cosmetic or therapeutic active ingredient. Some time after first use, the aplication surface of the composition changes from a first visual appearance to a second visual appearance due to a change in the composition.
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FLOATING SUSTAINED RELEASE PESTICIDE GRANULES

(WO2002087342) 07.11.2002 A01N 25/12 ALICOM - BIOLOGICAL CONTROL LTD.
A floating sustained release pesticide granule adapted for broadcast application for controlling a population of insects in an aquatic environment, comprising an effective amount of an active ingredient suspended in a water soluble sunscreen agent, and a floatation agent, said active ingredient, sunscreen agent and floatation agent embedded in an insoluble fibrous matrix such that when said granule is in contact with water, said water soluble sunscreen agent dissolves over time thereby releasing the active ingredient into the water in a sustained release manner. The invention additionally relates to a method for the production of said granule and to a method for controlling an insect population at the using said granule.
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COSMETIC COMPOSITIONS CONTAINING DISPERSION POLYMERS

(WO2002083085) 24.10.2002 A61K 8/81 ONDEO NALCO COMPANY
A cosmetically acceptable composition for treating hair, skin and nails comprising from about 0.001 to about 25 weight percent, based on polymer solids, of a stable dispersion in an aqueous salt solution of a cationic, anionic or nonionic polymer having a weight average molecular weight of from about 10,000 to about 50,000,000 and a method of treating hair, skin or nails are disclosed.
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COSMETIC COMPOSITIONS CONTAINING WATER-SOLUBLE POLYMER COMPLEXES

(WO2002083073) 24.10.2002 A61K 8/64 WSP CHEMICAL &TECHNOLOGY LLC
A composition for treating a keratin based substrate that includes a cosmetically acceptable medium containing a water-soluble interjacent complex. The water-soluble interjacent complex includes a first water-soluble polymer and a second water-soluble polymer formed by polymerizing one or more water-soluble monomers in the presence of the first water-soluble polymer. The water-soluble interjacent complex is characterized in that it forms a solution in water that is free of insoluble polymer particles. The water-soluble interjacent complex is used in a method of treating a keratin based substrate, whereby a cosmetically acceptable medium is applied to the substrate and contains from 0.1-20 % by weight of the water-soluble interjacent complex...
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ENCAPSULATED DYES IN COSMETIC COMPOSITIONS

(WO2002078665) 10.10.2002 A61P 17/00 COLOR ACCESS, INC.
The invention relates to a topical composition for application to skin comprising a cosmetically or pharmaceutically acceptable encapsulated liquid UV-absorbing naphthopyran or naphthoxazine dye, or a combination thereof, in combination with a cosmetically or pharmaceutically acceptable carrier.
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COSMETIC COMPOSITION WITH IMPROVED SKIN MOISTURIZING PROPERTIES

(WO2002078651) 10.10.2002 A61K 8/35 ALBERTO-CULVER COMPANY
The invention provides a cosmetic composition with improved moisturizing properties, improved skin feel and/or improved visual appeal, comprising a synergistic combination of coenzyme Q10? and urea. The coenzyme Q10? and urea act synergistically to confer improved, cosmetically desirable properties with respect to the composition of the invention.
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COSMETIC TOPICAL COMPOSITION COMPRISING A FUNCTIONAL AROMATIC DERIVATIVE BONDING AGENT

(WO2002076414) 03.10.2002 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functional aromatic derivative bonding agent having a structure selected from the group consisting of Formula (II), wherein X is one or more cosmetic benefit agents that may or may not be attached to a chemical linker; Y, Z, and W are selected from the group consisting of H, NO2?, CN, CF3?, SO2?R, COR, and X; V is selected from the group consisting of F, I, Br, Cl, NO2?, SOPh, N3?, Oar, OSO2?R, OR, SR, and NH2?; V' and Y' are selected from the group consisting of C, N, and combinations thereof; Z' and W' are selected from the group consisting of F, I, Br, Cl, H, SR, X, or combinations thereof; wherein R is an alkyl or phen...
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TOPICAL COMPOSITION COMPRISING AN ALDEHYDE OR KETONE-BASED COSMETIC BONDING AGENT

(WO2002072061) 19.09.2002 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise; a) a safe and effective amount of a bonding agent selected from the group consisting of aldehydes and ketones having the structure (I) wherein X represents a cosmetic benefit agent that may or may not be attached via a chemical linker and R represents hydrogen, straight or branched alkyls, substituted or unsubstituted aryls, and combinations thereof; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attache...
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TOPICAL COMPOSITION COMPRISING A THREE MEMBERED CYCLIC COMPOUND-BASED COSMETIC BONDING AGENT

(WO2002072060) 19.09.2002 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a three membered functional cyclic bonding agent having the structure (I) wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and Y represents O, NH, S, or Se; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various ...
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TOPICAL COMPOSITION COMPRISING A FUNCTIONALLY ALKYLATING COSMETIC BONDING AGENT

(WO2002072059) 19.09.2002 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functionally alkylating bonding agent having the structure (I); wherein X represents a cosmetic benefit agent that may or may not be attached via chemical linker; R is selected from the group consisting of COCH2?Cl, C OCH2?Br, COCH2?I, Cl, Br, I, N3?, CH2?OM', CH2?OT', CH2?OT', sulfonic esters; and wherein M' is (II); T' is (III); and T' is (IV); and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic ...
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TOPICAL COMPOSITION COMPRISING A FUNCTIONALIZED ACID ANHYDRIDE-BASED COSMETIC BONDING AGENT

(WO2002072058) 19.09.2002 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functionalized acid anhydride-based bonding agent having the structure (I) wherein X represents a cosmetic benefit agent that may or may not be attached via a chemical linker; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the cla...
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TOPICAL COMPOSITION COMPRISING A FUNCTIONALLY ACYLATING COSMETIC BONDING AGENT

(WO2002072057) 19.09.2002 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of an acylating bonding agent having the structure (I) wherein X represents a cosmetic benefit agent that may or may not be attached via a chemical linker and R represents N3?, Cl, Br or OM wherein M is an activated ester; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as w...
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TOPICAL COMPOSITION COMPRISING A DIAZONIUM SALT-BASED COSMETIC BONDING AGENT

(WO2002072056) 19.09.2002 A61K 8/40 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a diazonium salt bonding agent having the structure (formula I) wherein X represents a cosmetic benefit agent that may or may not be attached via a chemical linker; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed composit...
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TOPICAL COMPOSITION COMPRISING A CYCLIC IMIDOCARBONATE-BASED COSMETIC BONDING AGENT

(WO2002072055) 19.09.2002 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a cyclic imidocarbonate bonding agent having the structure (I) wherein X represents a cosmetic benefit agent that may or may not be attached via a chemical linker and R represents NH or O; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that incl...
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TOPICAL COMPOSITION COMPRISING A 1, 2-HETEROATOM CONSTITUTED DIENE COSMETIC BONDING AGENT

(WO2002072043) 19.09.2002 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a 1,2-heteroatom constituted diene bonding agent having the structure (F) wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker, Y represents N, CH, or CW wherein W is an alkyl and R represents O, S, or Se; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the com...
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SKIN COMPOSITION FOR REDUCING SKIN OILS AND GREASE

(WO2002067889) 06.09.2002 A61K 7/48 UNILEVER PLC
Improved skin compositions which are capable of reducing oil and grease secretion from the skin comprising a combination of niacinamide and a C11 - C30 alkyl or alkenyl ester of salicylic acid formulated in a specific carrier such as a vanishing cream base are disclosed.
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SELF-TANNING COMPOSITION IN SHEETED SUBSTRATE

(WO2002067887) 06.09.2002 A61K 8/35 DICIANNA, Valrie, Dumont
A plurality of sheet-like substrates infused by an aqueous self-tanning position is enclosed in a dispensing enclosure, from which they may be removed one at a time. The self-tanning composition adheres to each substrate while in the container, and transfers from the substrate when applied to the skin of a user. The aqueous self-tanning composition comprises 45 % to 65 % by weight of aqueous extract of Japanese green tea, 5 % to 15 % dihydroxyacetone, 5 % to 25 % ethylethoxydyglycol, 3 % to 10 % PPG-12-Buteth-16, 1 % to 13 % of a humectant, 0.05 % to 0.5 % of minerals, and other trace constituents such as an exfoliator, moisturizer, colorant, anti-oxidant, tanning accelerator, preservative, and sunscreen. The substrates are infused by being...
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PHOTOPROTECTING FORMULATIONS

(WO2002067885) 06.09.2002 A61K 8/81 SOCIETE L'OREAL S.A.
Topically applicable cosmetic/dermatological compositions well suited for both effective and SPF-enhanced UV-photoprotection of human skin, hair and/or scalp, most preferably packaged as spray delivery systems, contain (a) an effective UV-photoprotecting amount of at least one UV-A and/or UV-B sunscreen, most notably the sunscreen avobenzone, and (b) an amount of the copolymer tricontanyl PVP effective to statistically significantly enhance the SPF value of said at least one UV-A and/or UV-B or avobenzone sunscreen, formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor; the subject compositions optionally contain a thus-effective amount of an artificial/sunless tanning agen...
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SUNSCREEN FORMULATIONS COMPRISING INTERPOLYMERS

(WO2002067884) 06.09.2002 A61K 8/35 SOCIETE L'OREAL S.A.
Topically applicable cosmetic/dermatological compositions well suited for both effective and SPF-enhanced UV-photoprotection of human skin, hair and/or scalp, most preferably packaged as spray delivery systems, contain (a) an effective UV-photoprotecting amount of at least one UV-A and/or UV-B sunscreen, most notably the sunscreen avobenzone, and (b) an amount of the interpolymer PVP/dimethiconylacrylate/polycarbamyl/polyglycol ester effective to statistically significantly enhance the SPF value of said at least one UV-A and/or UV-B or avobenzone sunscreen, formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor; the subject compositions optionally contain a thus-effective am...
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WHITENING COMPOSITIONS CONTAINING ASCOMYCETE DERIVED ENZYME

(WO2002064150) 22.08.2002 A61K 8/66 COLOR ACCESS, INC.
The present invention relates to topical whitening compositions comprising a whitening effective amount of an Ascomycete-derived melanin-degrading enzyme extract and methods of preparing the composition. The composition provide a whitening effect which occurs by degrading melanin in the skin, yet the compositions themselves do not turn dark in color. The enzyme extract can be derived from Aspergillus fumigatus or Saccharomyces cerevisiae, and is added to the compositions of the present invention. The compositions containing the enzyme extract are twice as effective as kojic acid in producing a whitening effect on the skin.
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SUN PROTECTION PRODUCT

(WO2002064107) 22.08.2002 A61K 8/02 JOHNSON &JOHNSON GMBH
This invention relates to sun protection products comprising a carrier material to which a suitable sun protective composition has been applied. In particular the invention relates to a wipe with a sunscreen composition. The invention further concerns the manufacture and use of such products.
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COMPOSITIONS CONTAINING HETEROPOLYMERS AND OIL-SOLUBLE ESTERS AND METHODS OF USING SAME

(WO2002058642) 01.08.2002 A61K 8/02 L'OREAL SA
Structured compositions comprising at least one structuring polymer and at least one oil-soluble ester comprising at least one free hydroxy group. The compositions may also comprise at least one structuring polymer and at least one UV blocker. The at least one structuring polymer may be a polyamide polymer. This invention may be in the form of stable compositions such as, for example, make-up sticks, lipsticks, sunscreen sticks, anhydrous lip compositions, and anhydrous foundations.
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SUBSTANTIVE HYDROPHOBIC CATIONIC UV-ABSORBING COMPOUNDS

(WO2002058621) 01.08.2002 A61K 8/42 GALAXY SURFACTANTS LIMITED
Subsantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula (I) wherein R1? is a subsituent, selected from H, halo, -OH, -NH2?, -NO2?, -OCH3?, -N(CH3?)2?, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2? is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3? and R4? are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms, n is an integer from 1 to 6; R5? is selected from an alkyl group containing from 8 to 22 carbon atoms; al...
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COMPOSITIONS AND METHODS FOR DECREASING COLOR LOSS FROM DYED HAIR

(WO2002051370) 04.07.2002 A61K 8/69 AVON PRODUCTS, INC.
The present invention provides a novel hair composition, method and system for preventing color loss form dyed hair. The method of decreasing color loss from dyed hair includes a composition having a halogenated compound in an amount effective to decrease such color loss.
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THE ENCAPSULATION OF ACTIVES IN CORE-SHELL AND GEL PARTICLES

(WO2002050166) 27.06.2002 A61K 8/04 DOW CORNING CORPORATION
This invention pertains to silicone core-shell or gel particles that contain active ingredients. The silicone particles are produced by emulsifying and reacting a composition comprising a siloxane have a first reactive group, a crosslinker having a second reactive group, at least one emulsion liquid, a surfactant and an active ingredient. The active ingredient is encapsulated in the silicone particle and are useful in personal care products, textiles, auto care products, and laundry products for the delivery of active ingredients.
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BENZOPHENONE UV-ABSORBERS WITH HETEROCYCLIC SUBSTITUENTS

(WO2002048118) 20.06.2002 C07D 249/08 CIBA SPECIALTY CHEMICALS HOLDING INC.
Compounds having the formula: wherein R1? represents hydrogen, C1?-C20? alkyl which is unsubstituted or substituted by one or more ammonium, mono-, di-, tri or tetra-C1?-C12? alkylammonium groups or by one or more sulphonium groups or represents an aralkyl residue having a total of from 7 to 10 carbon atoms and, in which, the aryl group is unsubstituted or substituted by C1?-C4?alkyl, C1?-C4? alkoxy or halogen and Z is a group selected from R2?, R3? and R4?, independently, representing hydrogen, C1?-C4?alkyl, C1?-C4? alkoxy, halogen, NHCOC1?-C4? alkyl or phenyl which is unsubstituted or substituted by. C1?-C4? alkyl, C1?-C4? alkoxy or halogen, a process for their preparation and use of the compoun...
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WATER-IN-OIL INSECT REPELLENT COMPOSITION AND METHOD OF APPLICATION TO THE SKIN

(WO2002043656) 06.06.2002 A01N 25/24 AVON PRODUCTS, INC.
The present invention is an insect repellent water-in-oil emulsion having an internal aqueous phase and an external oil phase. It also has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin. The insect repellent active is substantially present in the oil phase. Also disclosed is a method of repelling insects from the skin by applying to the skin the above composition.
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EXTENDED DURATION INSECT REPELLENT COMPOSITION AND METHOD OF APPLICATION TO THE SKIN

(WO2002043491) 06.06.2002 A01N 25/24 AVON PRODUCTS, INC.
Disclosed is an insect repellent composition. The composition has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin, and an amount of a urethane polymer sufficient to form a film on the surface of the skin. The composition also has a cosmetically-acceptable vehicle. Also disclosed is a method of repelling insects from the skin by applying the composition to the skin.
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FOAMING INSECT REPELLENT COMPOSITIONS

(WO2002043490) 06.06.2002 A01N 25/16 AVON PRODUCTS, INC.
There is provided a foaming composition having one or more insect repellents in an amount effective to repel insects. The foaming composition is aesthetically acceptable and allows for controlled, targeted, even application of the insect repellent to the skin. The present invention also provides a method of applying such a composition to the skin.
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AEROSOL INSECT REPELLENT COMPOSITION HAVING LOW VOC CONTENT AND METHOD OF APPLYING SAME TO THE SKIN

(WO2002043483) 06.06.2002 A01N 25/06 AVON PRODUCTS, INC.
Disclosed is an aerosol insect repellent composition. The composition has (a) an amount of an insect repellent effective to repel insects when applied to the skin and (b) a cosmetically-acceptable vehicle in which to disperse and deliver the insect repellent active. The vehicle has (i) a VOC component capable of volatilizing upon exposure to a reduction in pressure for delivering the composition in an aerosol form, and (ii) a non-VOC component. The aerosol composition has a VOC content of not greater than about 55 wt. % based upon the weight of the aerosol composition. Further disclosed is a method of repelling insects from skin wherein the aerosol composition is applied to or sprayed on the skin.
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A TRANSFER RESISTANT ANHYDROUS COSMETIC COMPOSITION

(WO2002041854) 30.05.2002 A61K 8/891 L'OREAL S.A.
A composition with transfer resistance and/or waterproof properties comprising at least one linear dimethicone; and at least one block copolymer film former chosen from tri-block copolymer film formers, multi-block copolymer film formers and radial block copolymer film formers. The invention also provides for a cosmetic powder delivery system and a method of delivering a powder composition to a keratinous substance.
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TOWELETTE PRODUCT WITH SUNSCREEN AGENT

(WO2002034224) 02.05.2002 A61K 8/02 UNILEVER PLC
A cosmetic towelette is provided which includes a water-insoluble substrate and a fluid cosmetic composition impregnated into the substrate. The composition has a viscosity ranging from about 1 cps to 10,000 cps. The composition includes a water phase, a sunscreen phase and a surfactant system. The sunscreen phase is immiscible with the water phase and contains at least 25 % organic sunscreen agent. Towelettes impregnated with the composition impart an effective SPF to the skin when applied thereto.
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ACRYLIC-BASED COPOLYMER COMPOSITIONS FOR COSMETIC AND PERSONAL CARE

(WO2002034218) 02.05.2002 A61K 8/81 3M INNOVATIVE PROPERTIES COMPANY
A composition for nails, skin and hair in the form of an aqueous emulsion or dispersion is provided. The composition comprises: (a) at least one copolymer comprising (i) about 10 to 85 weight percent of (meth)acrylate ester of C4? to C18? straight and/or branched chain alkyl alcohol, (ii) about 10 to 70 weight percent of (meth)acrylate ester of a saturated or unsaturated cyclic alcohol containing 6 to 20 carbon atoms; and (b) an aqueous carrier, solvent, or vehicle component. When used in hair applications, the inventive composition is not a reshapable composition.
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ACYLATED CELLOBIOSE COMPOUNDS

(WO2002032914) 25.04.2002 C07H 13/06 UNILEVER PLC
Acylated cellobiose compounds (CHME) which satisfy the formula:- wherein X represents an acyl group (R-CO-) or H, Z represents an acyl group (R'-CO-) or H and not more than a minority of X + Z residues represent H, R represents a saturated or unsaturated, linear or branched chain hydrocarbon residue of 5 to 31 carbon atoms and R' represents a residue, different from R, which is:- (i) a saturated or unsaturated, linear or branched chain hydrocarbon residue of 1 to 31 carbon atoms, or (ii) an aromatic hydrocarbon residue, or (iii) a cycloaliphatic hydrocarbon, each optionally substituted. CHME esters are particularly suited to thickening or structuring a water-immiscible liquid, for example, a phase in a cosmetic formulation, such as antipers...
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HETEROARYL SUBSTITUTED HYDROXYPHENYLTRIAZINE UV-ABSORBERS

(WO2002028854) 11.04.2002 A61K 8/49 CIBA SPECIALTY CHEMICALS HOLDING INC.
The present invention provides compounds having the formula (1) in which each of the radicals R1?, R2?, R3? and R4?, independently, represent hydrogen, hydroxy, halogen, C1?-C20?-alkyl, C1?-C20?-alkoxy, CN or COOR5?, in which R5? is C1?-C20?-alkyl and Z represents a heterocyclic residue selected from the 2H-benzo[1,2-d]triazol-2-yl, 2H-naphtho[1,2-d]triazol-2-yl, benzimidazol-2-yl, benzoxazol-2-yl and benzofuran-2-yl moieties, optionally substituted by C1?-C4?-alkyl, C1?-C4?-alkoxy, halogen or NHCOC1?-C4?-alkyl, a process for their preparation, new intermediate benzoxazinones useful for their preparation and use of the compounds of formula (1) as UV-absorbers which have improved absorption spectrum charac...
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CONCORDANTLY UV-PHOTOPROTECTING AND ARTIFICIAL TANNING COMPOSITIONS

(WO2002028359) 11.04.2002 A61K 8/04 SOCIETE L'OREAL S.A.
Topically applicable cosmetic/dermatological compositions well suited for both effective and typically SPF-enhanced photoprotection and artificial tanning of human skin and/or scalp, advantageously packaged as spray delivery systems, contain: (i) a UV-photoprotecting effective amount of a UV-photoprotecting agent, (ii) an artificial tanning effective amount of an artificial tanning agent, and (iii) a compatibilizing and typically SPF-enhancing amount of a silicone/acrylate graft copolymer which comprises an acrylic backbone having pendant organosiloxane branches depending therefrom, in particular poly(isobutyl methacrylate-co-methyl FOSEA)-g-poly(dimethylsiloxane) or a terpolymer of isobutyl methacrylate, acrylic acid and a methacryloxyprop...
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TOPICAL POLYMERIC ANTIMICROBIAL EMULSION

(WO2002026211) 04.04.2002 A01N 25/04 CHEMEQ LTD
An emulsion composition for the topical application comprising: (a) A polymeric oily phase; (b) A polymeric emulsifier; (c) An aqueous phase; (d) A polymeric antimicrobial andoptionally one or more components selected from polymeric film formers, inorganic and polymeric stabilizers, other inorganic or polymeric excipients and mixtures thereof.
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PAIN RELIEVER AND METHOD OF USE

(WO2002022120) 21.03.2002 A61K 31/165 MEDICAL MERCHANDISING, INC.
A composition containing capsicum extract together with other ingredients to neutralize the discomfort resulting from the application of capsicum extract to the skin enabling treatment of many types of discomforts, including arthritis pain, neuropathy, post surgical scarring, hemorrhoid pain and itching, and pruritis without the discomfort normally associated with the topical application of capsicum extract.
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COSMETICS TO SUPPORT SKIN METABOLISM

(WO2002011717) 14.02.2002 A61K 8/35 JUVENON, INC.
Disclosed herein are cosmetic compositions to support skin metabolism and ameliorate the appearance of aging. Cosmetics such as masks, sunscreens, and lotions are particularly preferred. The compositions contain 0.01-30 % of an antioxidant (preferably R-a-lipoic acid), 0.01-30 % of a carnitine (preferably ALC), and optionally 0.01-15 % of a coenzyme Q (preferably Q10), and/or 0.01-30 % of a creatine. Also disclosed are methods of treatment of aged, photoaged, dry, lined or wrinkled skin. A method of protecting skin from the deleterious effects of sun exposure includes applying a sunscreen composition containing 0.001-10 % antioxidant, 0.001-10 % carnitine, and optionally 0.001-10 % coenzyme Q and/or 0.1-40 % creatine. The antioxidant, a car...
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PLASTICIZED WATERBORNE POLYURETHANE DISPERSIONS AND MANUFACTURING PROCESS

(WO2002008327) 31.01.2002 A61K 8/87 NOVEON IP HOLDINGS CORP.
Waterborne polyurethane dispersions are prepared by reacting (1) at least one polyisocyanate; (2) at least one active hydrogen containing compound, such as a polyol or a polyamide; and (3) optionally, at least one water-dispersability enhancing compound having water-dispersion enhancing groups, in order to form an isocyanate terminated prepolymer. The prepolymer subsequently is (1) optionally neutralized by reaction with at least one neutralizing agent, (2) dispersed in water, and then (3) chain extended by reaction with at least one of water, inorganic or organic polyamine having an average of about 2 or more primary and/or secondary amine groups, or combinations thereof. At least one plasticizer is introduced into the reaction mixture at ...
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COMPOSITIONS USEFUL FOR REGULATING HAIR GROWTH CONTAINING METAL COMPLEXES OF OXIDIZED CARBOHYDRATES

(WO2002007700) 31.01.2002 A61K 8/19 THE PROCTER &GAMBLE COMPANY
A stable cosmetic, dermatological, or pharmaceutical composition comprising: (a) from about 0.001 % to about 99.9 %, by weight, of at least one metal complex of an oxidized carbohydrate; wherein the metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate; and (b) from about 0.1 % to about 99.999 %, by weight, of a vehicle, wherein the vehicle comprises at least about 5 %, by weight of the composition, of propylene glycol.
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METHOD OF REGULATING HAIR GROWTH USING METAL COMPLEXES OF OXIDIZED CARBOHYDRATES

(WO2002007685) 31.01.2002 A61K 8/19 THE PROCTER &GAMBLE COMPANY
A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition comprising: (a) from about 0.001 % to about 99.9 %, by weight, of at least one metal complex of an oxidized carbohydrate, wherein the metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate; and (b) from about 0.1 % to about 99.999 %, by weight, of a vehicle.
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A METHOD FOR ENZYMATIC TREATMENT OF TEXTILES SUCH AS WOOL

(WO2002004739) 17.01.2002 D06M 16/00 THE NOTTINGHAM TRENT UNIVERSITY
The application provides a method of treating fibrous textile goods comprising treating the fibrous textile goods with an enzyme. This enzyme can be used to covalently link one or more acitve functional compounds to the fibres and/or to trap one or more active functional compound within an inter-fibre matrix and/or within an intra-fibre matrix formed by the action of the enzyme. Preferably, the enzyme is a traglutaminase, especially a calcium-dependent transglutaminasc. The enzyme may be used to add primary-amine containing active agents to the textile goods and also for the addition of proteins or peptides that have functional groups linked to them.
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B COMPLEX VITAMIN COMPOSITIONS THAT PROTECT AGAINST CELLULAR DAMAGE CAUSED BY ULTRAVIOLET LIGHT

(WO2002003942) 17.01.2002 A61K 8/67 PLANET BIOTECH INC.
The present invention relates generally to the use of vitamin B12 (cobolamin or cyanocobalamin) alone or in combination with other photoprotective agents, including specifically other vitamins such as vitamin B9 (folic acid or folate) and vitamin B3 (niacin or niacinamide), or any chemical derivative of these vitamins and their salts, as a filter to protect cells against the damaging effects of ultraviolet (UV) light. The invention is, in one aspect, a method of reducing the rate of UV damage to cells exposed to a UV light source, by treating the cells with the vitamin composition, either alone or in combination with other photoprotective agents. Other aspects of the invention are compositions comprising effective amounts of vitamin B12 alo...
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ANHYDROUS COSMETIC COMPOSITIONS

(WO2002003935) 17.01.2002 A61K 8/31 THE PROCTER &GAMBLE COMPANY
An anhydrous skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin conditioning agent and a volatile siloxane. Inclusions of the select elastomers provide improved uniform distribution of the pigments.
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ANHYDROUS COSMETIC COMPOSITIONS

(WO2002003933) 17.01.2002 A61K 7/02 THE PROCTER &GAMBLE COMPANY
An anhydrous skin treatment composition is provided which includes a crosslinked emulsifying siloxane elastomer, at least 20 % humectant and a volatile siloxane. Inclusion of the elastomer provides a non-traditional smooth/silky feel to the skin upon application with a non-draggy rub in.
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COSMETIC COMPOSITIONS

(WO2002003932) 17.01.2002 A61K 8/31 THE PROCTER &GAMBLE COMPANY
A skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin-conditioning agent, a volatile siloxane and water. Inclusions of the select elastomers provide improved uniform distribution of the pigments.
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METHODS OF ENHANCING DELIVERY OF OIL-SOLUBLE SKIN CARE ACTIVES

(WO2002003930) 17.01.2002 A61K 8/06 THE PROCTER &GAMBLE COMPANY
Water-in-silicone emulsion compositions containing a silicone oil, a silicone elastomer, and an oil-soluble skin care active such as terpene alcohols, phytosterol, anti-acne actives, beta-hydroxy acids, vitamin B3? compounds, retinoids, anti-oxidants/radical scavengers, chelators, flavonoids, anti-inflammatory agents, anti-cellulite, topical anesthetics, and mixtures thereof. Methods of enhancing the delivery of oil-soluble skin care actives using silicone elastomers.
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SUNSCREEN COMPOSITION WITH ENHANCED SPF AND WATER RESISTANT PROPERTIES

(WO2002003929) 17.01.2002 A61K 8/35 COLLABORATIVE TECHNOLOGIES, INC.
The present invention relates to a sunscreen formulation which exhibits superior ultraviolet protection and water resistance than prior art sunscreen compositions. The sunscreen formulation comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition comprising a rheological modifying agent and water. The sunscreen formulation is bustantially free of surfactants. According to a preferred embodiment, the sunscreen active agent is ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological modifying agent. Another embodiment of the present invention is a method of protecting skin or hair from ...
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COSMETIC COMPOSITION FOR STRESSED SKIN UNDER EXTREME CONDITIONS

(WO2001095728) 20.12.2001 A61K 8/19 FD MANAGEMENT, INC.
A cosmetic composition is provided effective against stresses of climate extremes. The composition includes hot, cold and dry climate treatment portions. The hot climate treatment portion has a first botanical ingredient to impart a cool sensation, and a sunscreen agent. The cold climate treatment portion has a second botanical ingredient to combat skin inflammation, and a silicone fluid or hydrocarbon for retaining moisturize. The dry climate treatment portion has a third botanical ingredient to impart moisturization and an ester.
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MULTI-COMPOSITION STICK PRODUCT AND A PROCESS AND SYSTEM FOR MANUFACTURING THE SAME

(WO2001091605) 06.12.2001 A45D 40/04 WYETH
A multi-composition stick product (10), such as a lip balm, sun screen, deodorant, or glue stick. The multi-composition stick product (10) including a stick composition (14) molded in the container (12) so as to contact the walls thereof and be advanceable or ejected therefrom. The stick composition (14) includes a first composition and a second composition. The first and second compositions differ in at least one component, such as a medicament, colorant, fragrance, flavorant, sunscreen, preservative, conditioner, moisturizer, emollient, or surfactant. Furthermore the first and second compositions are arranged in a predetermined non-random pattern that is reproducible. Also described is the method and apparatus for manufacturing the multi-...
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SKIN CARE MOISTURIZING AND SUNSCREEN COMPOSITIONS COMPRISING ORGANIC PARTICULATE MATERIAL

(WO2001089466) 29.11.2001 A61K 8/04 THE PROCTER &GAMBLE COMPANY
The present invention relates to a topical cosmetic composition with an aqueous continuous phase, in the form of a lotion, cream or gel, comprising: i) from 0.01% to 25%, by weight, of an organic particulate material having a median particle size of from 0.5 to 30 mm; ii) greater than 8%, by weight, of a humectant selected from glycerine, polyalkylene glycol, urea, D or DL panthenol, hexane-1, 2, 6- triol, guanidine or its derivatives, alkylene glycols such as butylene glycol and propylene glycol, and mixtures thereof; iii) from 2% to 20%, by weight, organic sunscreen.for providing highly efficacious levels of moisturisation and UV protection while maintaining optimum skin feel. Preferred embodiments are oil in water emulsions wherein the p...
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DEVICE AND METHOD FOR ULTRAVIOLET RADIATION MONITORING

(WO2001084095) 08.11.2001 G01J 1/42 APA OPTICS, INC.
An ultraviolet radiation monitor is disclosed. The monitor includes an aluminum gallium nitride-based detector, such as a Schottky junction fabricated with aluminum gallium nitride and a Schottky layer containing palladium, and a processor. The composition of the detector is tailored so that the detector is responsive substantially only to radiation of certain wavelengths, such as UV-B. The processor is adapted to receive user input of the user's skin type and ultraviolet-blocking power of any sunscreen the user is wearing. The processor is also adapted to read the signal generated by the detector and calculate the intensity of the ultraviolet radiation received by the detector. The processor is further adapted to calculate the maximum leng...
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AMPHOLYTIC POLYMER DISPERSION COMPOSITION AND METHOD OF USE

(WO2001074915) 11.10.2001 B01F 17/00 CALGON CORPORATION
Disclosed are novel aqueous dispersions of ampholytic polymers. The dispersion pH of 2 to 6 allows the dispersion to contain high levels of the ampholytic polymer and remain pourable where similarly active solutions would be in a non-pourable gel form. The use of the novel aqueous dispersions of ampholytic polymer, in a cosmetically acceptable medium for the treatment of a keratin-containing substrate is also disclosed. The use of the novel aqueous dispersions of ampholytic polymers to thicken aqueous solutions as an additive in the manufacture of paper, as a component in drilling fluid compositions, as a component of cementing compositions and as an agent for waste water treatment is further disclosed.
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COMPOSITION FOR IMPROVING SKIN LIPID BARRIER FUNCTION

(WO2001074327) 11.10.2001 A61K 8/36 COLOR ACCESS, INC.
The invention relates to a composition for topical application to the skin comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/photo-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.
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NOVEL DELIVERY SYSTEM FOR INORGANIC SUNSCREENS

(WO2001072276) 04.10.2001 A61K 8/04 FINETEX, INC.
A novel delivery system for physical, inorganic sunscreens for use in sunscreen preparations is disclosed. One or more inorganic suscreen agents, such as micronized zinc oxide and micronized titanium dioxide, is dispersed in a solid dispension vehicle preferably selected from the group consisting of stearyl benzoate, behenyl benzoate and arachidyl benzoate, to thereby produce a solid dispersion of inorganic sunscreen agents for use in sunscreen preparations. The micronized sunscreens are embedded in a solid product which does not require mixing or regrinding before use. A solid formulation avoids the problems inherent in a fluid emulsion or dispersion, i.e., migration or settling out of the contents, which requires mixing and/or regrinding ...
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COSMETIC COMPOSITIONS

(WO2001070190) 27.09.2001 A61K 8/29 UNILEVER PLC
Cosmetic compositions are described which comprise a skin lightening agent (such as niacinamide) or a precursor thereof and titanium dioxide particles having a particle size of less than 100 nm. The compositions are useful in lightening the colour of skin and in inhibiting or preventing the tanning of skin.
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METHOD AND COMPOSITION FOR SKIN LIGHTENING APPLYING CARBOXYLIC ACIDS

(WO2001070189) 27.09.2001 A61K 8/34 UNILEVER PLC
A method and composition is provided for treating skin to achieve lightening by applying a composition that includes an anti-microbial agent, an alpha- and/or beta-hydroxy carboxylic acid and a sunscreen.
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PERSONAL WASH SUNSCREEN COMPOSITIONS WHICH DEPOSIT AND LATHER WELL

(WO2001068036) 20.09.2001 A61K 8/35 UNILEVER PLC
The invention provides personal wash compositions which deposit high levels of sunscreen while maintaining good lather. Enhanced deposition, from bar or liquid, is based on specific sunscreens used, particularly on their solubility.
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STABILIZED MICROFIBRILLAR CELLULOSE

(WO2001066600) 13.09.2001 C08B 11/145 HERCULES INCORPORATED
A derivatized microfibrillar cellulose, derivatized to contain a substituent that provides cationic charge. A method for producing a derivatized microfibrillar cellulose to include a substituent that provides cationic charge, which may include derivatizing a microfibrillar cellulose to obtain a derivatized microfibrillar cellulose, microfibrillizing a derivatized non-microfibrillar cellulose to produce a derivatized microfibrillar cellulose, or microfibrillizing and derivatizing a non-microfibrillar cellulose substantially simultaneously. A method of modifying the rheological properties of a composition of matter using derivatized microfibrillar cellulose. Methods of improving coatings, paper manufacture, and the stability of emulsions, dis...
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METHODS USING PHYTOL TO IMPROVE THE APPEARANCE OF SKIN AND COMPOSITIONS FOR SUCH METHODS

(WO2001066080) 13.09.2001 A61K 8/34 AVON PRODUCTS, INC.
There are provided methods of enhancing the appearance of human skin comprising applying a composition having (i) phytol in an amount about 0.0001 wt% to about 50 wt% based on the total weight of the composition, and (ii) at least one retinoid in an amount about 0.001 wt% to about 1.5 wt% based on the total weight of the composition. Alternatively, the composition used in the method for enhancing the appearance of human skin may have phytol and perilla oil.
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MICRONIZED ZINC OXIDE SKIN PROTECTOR FORMULATION

(WO2001066075) 13.09.2001 A61K 8/19 AUSTRALIAN IMPORTERS, LTD.
Micronized zinc oxide skin protector formulations comprising between about 8 % and 40 % zinc oxide. These compositions preferably comprise micronized zinc oxide, preferably obtained via a 'wet' micronization process in oil, and also preferably include agents that block or screen light in the visible and/or infrared ranges, and also preferably include hydrotropes and humectants to aid in the dissipation of heat caused by the irradiation of light in the visible and/or infrared ranges, and alleviate the photo-damage and/or heat damage associated with such irradiation. These compositions are preferably readily absorbable, transparent, non-irritating, non-comedogenic and are hypo-allergenic. The compositions may comprise additional ingredients s...
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COMPOSITIONS FOR PREVENTING CELLULITE IN MAMMALIAN SKIN

(WO2001060331) 23.08.2001 A61K 8/36 ZEN-BIO, INC.
The present invention relates to a method for combating cellulite or reducing localized fatty excesses which comprises administering to a person having cellulite or localized fatty excesses a body slimming amount of a composition containing 10-trans, 12-cis conjugated linoleic acid.
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PHOTOSTABLE SUNSCREEN COMPOSITIONS CONTAINING POLYESTERS OF NAPHTHALENE DICARBOXYLIC ACID

(WO2001052807) 26.07.2001 A61K 8/35 HAARMANN &REIMER
A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL$m(3) 1789), and a stabilizer for the dibenzoylmethane derivative having structure (I) wherein each R', same or different, is an alkyl group, straight or branched chain, having 1 to 22 carbon atoms. These diesters of structure (I) are quite effective in stabilizing the dibenzoylmethane derivative UV-A filter compounds making them more effective, and effective for longer periods of time.
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DERMATOLOGICAL SUSPENSIONS (MICRO-MATRIX)

(WO2001051010) 19.07.2001 A61K 8/14 CLINICAL RESULTS, INC.
A dermatologically or cosmetically useful composition comprising a lipid phase and an anchoring agent, wherein the lipid phase and the anchoring agent are combined to form a micellular micro-matrix, and further wherein a dermatologically or cosmetically active payload may be optionally encapsulated within the micro-matrix.
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A SKIN CARE COMPOSITION THAT MEDIATES CELL TO CELL COMMUNICATION

(WO2001043704) 21.06.2001 A61K 8/34 AVON PRODUCTS, INC.
There are disclosed skin treatment compositions containing cell signaling compounds, which induce and promote the biosynthesis and/or bioactivity of endogenous chemicals that mediate cell to cell communication in the skin between keratinocytes, fibroblasts and other cell types present in the skin. The cell signaling compound is selected from the group consisting of: andrographolide and its derivatives; adenosine cyclic phosphate and its derivatives; hydrolyzed milk proteins; sunflower seed extract; plankton extract; phytol and its derivatives; and mixtures thereof.
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DOSIMETER FOR SUN RADIATION FOR USE WITH SUNSCREEN LOTION

(WO2001042747) 14.06.2001 G01J 1/50 SKYRAD LTD.
Disposable dosimeter for sun radiation comprising polymeric matrix with distributed therein at least one active chemical compound capable to change its original color to a new color due to a reversible photo-chemical reaction induced upon exposing the dosimeter to UV radiation. The transparency of the matrix is sufficient to enable easy visual detection of the change of the original color to the new color. The matrix is provided with porous structure suitable for absorbing thereinto of a sunscreen lotion when it is applied to the dosimeter.
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ULTRAVIOLET RADIATION ABSORBING WAXES USEFUL IN COSMETIC COMPOSITIONS

(WO2001041715) 14.06.2001 A61K 8/37 THE C.P. HALL COMPANY
The compounds of formula (I), suitable solvents for the compounds, and use of the compounds as waxes, UV absorbers, and skin conditioners is disclosed. A compound of formula (I) is a wax at room temperature, absorbs UVA and UVB radiation, and boosts the sun protection factor of sunscreen compositions. The compounds of formula (I) have utility in a variety of cosmetics and other compositions including waxes for coating, polishing, and sealing, textile and leather manufacture, adhesives, and crafts. The compounds of formula (I) also have utility in the treatment of skin conditions including acne, psoriasis, seborrheic dermatitis, dandruff, warts, corns, calluses, ringworm infection, wrinkling, yellowing, leatheriness, mottling, and hyperpigme...
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A PARTICLE COMPRISING A HOST LATTICE AND A GUEST, ITS PREPARATION AND USE IN ULTRAVIOLET LIGHT SCREENING COMPOSITIONS

(WO2001040114) 07.06.2001 A61K 8/19 ISIS INNOVATION LIMITED
A UV screening composition comprising novel particles which are capable of absorbing UV light so that electrons and positively charged holes are formed within the particles is disclosed. These particles comprise a host lattice incorporating a second component to provide luminescence trap sites and/or killer sites, said second component being niobium, vanadium, antimony, tantalum, strontium, calcium, magnesium, barium, molybdenum or silicon.
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METHOD OF TREATING FABRIC

(WO2001038470) 31.05.2001 C11D 3/22 UNILEVER PLC
A method of treating fabric comprising dyed cellulosic fibres to increase its photostability comprises applying to the fabric a substance which is absorbed into and/or coated on to the fibres such that the diffusion of atmospheric oxygen into and/or within the fibres is inhibited. The method may be carried out as part of a laundering process or an industrial textile treatment. The method is particurlarly effective when the compound is used in conjuction with a sunscreen such as a benzotriazole.
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COMPOSITION AND METHOD FOR PROTECTING FROM NEMATOCYST STING

(WO2001037778) 31.05.2001 A61K 8/19 NIDARIA TECHNOLOGY LTD.
This invention provides a composition comprising formalin and chloride. In another aspect of the invention, the composition may also comprise magnesium chloride, calcium chloride, or lanthanum chloride. This invention provides a composition comprising formalin and lanthanum chloride. This invention provides an ointment which comprises a composition comprising formalin and chloride. This invention provides a method of inhibiting nematocyst or polar capsule discharge and a method of protecting a subject from a sting from an organism discharging nematocyst or polar capsule discharge comprising applying an effective amount of the composition of comprising formalin and chloride, to the skin of a subject prior to contact with nematocysts or polar...
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PERSONAL CARE ARTICLES COMPRISING ANIONIC POLYMER COACERVATE COMPOSITIONS

(WO2001035924) 25.05.2001 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a substantially dry, disposable personal care article comprising: a) a water insoluble substrate comprising a nonwoven layer; and b) a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10 % to about 1000 %, by weight of the water insoluble substrate, of a therapeutic benefit composition comprising: 1) a safe and effective amount of anionic polymer; 2) a safe and effective amount of a cationic surfactant; wherein said composition forms a coacervate when said article is exposed to water. These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invent...
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PERSONAL CARE ARTICLES COMPRISING CATIONIC POLYMER COACERVATE COMPOSITIONS

(WO2001035923) 25.05.2001 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a substantially dry, disposable personal care article comprising: a) a water insoluble substrate comprising a nonwoven layer; and b) a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit composition comprising: c) a safe and effective amount of a cationic polymer exhibiting a Relative Hydrophobic Contribution of from about 0.2 to about 1.0; d) a safe and effective amount of an anionic surfactant; wherein said composition forms a coacervate when said article is exposed to water. These articles have been found to be particularly useful for personal...
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PERSONAL CARE ARTICLES COMPRISING A HYDROPHILIC CONDITIONING AGENT EXHIBITING A DEFINED LEACHING VALUE

(WO2001035906) 25.05.2001 A61K 8/02 THE PROCTER AND GAMBLE COMPANY
The present invention relates to a substantially dry, disposable personal care article comprising: a) a water insoluble substrate comprising a nonwoven layer; and b) a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10 % to about 1000 %, by weight of the water insoluble substrate, of a therapeutic benefit composition comprising a hydrophilic conditioning agent wherein the agent exhibits a Leaching Value of less than about 25 % at 1 minute and less than about 50 % at 5 minutes when the article is exposed to water. These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invention...
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PERSONAL CARE ARTICLES COMPRISING CATIONIC POLYMER COACERVATE COMPOSITIONS

(WO2001035905) 25.05.2001 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a substantially dry, disposable personal care article comprising: (a) a water insoluble substrate comprising a nonwoven layer; and (b) a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 100%, by weight of the water insoluble substrate, of a therapeutic benefit composition comprising: (c) a safe and effective amount of a cationic; (d) a safe and effective amount of an anionic surfactant; wherein said composition forms a coacervate when said article is exposed to water. These articles have been found to be particularly useful for personal cleansing application, namely for the skin and hair. Thus, the present invention f...
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BIOADHESIVE NANOPARTICULATE COMPOSITIONS HAVING CATIONIC SURFACE STABILIZERS

(WO2001026635) 19.04.2001 A61K 9/113 ELAN PHARMA INTERNATIONAL LTD.
Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the...
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DRUG DELIVERY OF PHASE CHANGING FORMULATION

(WO2001022907) 05.04.2001 A61K 9/00 ZARS
This invention relates to an apparatus and method of drug delivery on a human body surface. The formulation comprises a drug, a conversion agent capable of converting the formulation from a less solid phase to a coherent, soft, solid phase, and a vehicle medium or carrier for the drug and conversion agent. The drug formulation is applied to this human body surface in its less than solid phase and is subsequently converted to a soft solid phase while the drug is being delivered through the human body surface. After delivery of the drug is complete, the soft solid formulation can be removed or peeled from the body surface as a coherent solid formulation. The drug formulation provides control over drug delivery rates and allows the formulation...
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ARTICLE FOR THE DELIVERY OF FOAM PRODUCTS

(WO2001021501) 29.03.2001 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a low cost, article for the delivery of personal care foams comprising a package comprising a container having flexible, deformable walls, an opening portion, a first sponge having a density of from about 1.5 to about 3.0 lbs./ft?3; an indentation force deflection of from about 40 to about 65 lbs./50 in?2; and a porosity of from about 50 pores per inch to about 100 pores per inch; and a second sponge having a density of from about 1.30 to about 2.00 lbs./ft?3; an indentation force deflection of from about 40 to about 95 lbs./50 in?2; and a porosity of from about 10 pores per inch to about 50 pores per inch; and a foaming compositions; wherein the ratio of the combined bulk volume of the sponges to th...
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PERSONAL-CARE COMPOSITIONS

(WO2001021141) 29.03.2001 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The invention provides the use of a polymeric component capable of forming liquid crystals upon contact with water, and/or a polymeric component which is in the form of liquid crystals, each of these polymeric components comprising at least one polymeric compound, for the preparation of a composition for the reduction of the activity of hydrolytic enzymes, in particular lipase enzymes or the formation of fatty acids by lipase enzymes, the composition preferably being for reduction of skin irritation, acne, eye irritation, dandruff or for improvement of skin healing. The invention also provides specific personal-care compositions containing these polymeric components. The polymeric compound has preferably a cloud point of 35 C or below, an...
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TOPICAL TREATMENT OF STREPTOCOCCAL INFECTIONS

(WO2001019391) 22.03.2001 A61K 38/46 NEW HORIZONS DIAGNOSTICS, INC.
The present invention discloses a method and composition for the topical treatment of streptococcal infections by the use of a lysin enzyme blended with a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological streptococcal infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lysin enzyme produced by group C streptococcal bacteria infected with a C1 bacteriophage. The therapeutic agent can be in a pharmaceutically acceptable carrier.
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THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VARIOUS ILLNESSES

(WO2001019385) 22.03.2001 A61K 38/46 NEW HORIZONS DIAGNOSTICS, INC.
A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein said modified version of said at least one lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upp...
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PRODUCT-STRUCTURANT COMPOSITION FOR PERSONAL CARE FORMULATIONS

(WO2001019343) 22.03.2001 A61K 8/02 ISP INVESTMENTS INC.
A product-structuring composition which forms a bilayer lamellar gel network in an oil-in-water system comprising (a) a cationic swellant which is a fatty acid adduct of amidopropyldimethyl-2-hydroxyethyl ammonium halide, and (b) a gellant blend of low HLB emulsifiers having a resultant HLB of about 1.5 to 4.5.
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COSMETIC COMPOSITIONS CONTAINING SPECIFIC POLYSACCHARIDE RESINS

(WO2001017488) 15.03.2001 A61K 8/02 L'OREAL SA
An embodiment of the present invention is a composition with enhanced film forming properties. The compositions of the present invention contain (a) at least one polysaccharide resin and (b) a film former other than said at least one polysaccharide resin. A cosmetic or pharmaceutical composition comprising the compositions of the present invention may be transfer-resistant, long wearing, and water resistant. Cosmetic and pharmaceutical compositions of the invention also may result in a flexible film that does not flake or crumble.
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METHODS OF LIGHTENING KERATINOUS TISSUE BY TOPICAL APPLICATION OF OXIME COMPOUND CONTAINING COMPOSITIONS

(WO2001013882) 01.03.2001 A61K 8/40 THE PROCTER &GAMBLE COMPANY
The present invention relates to methods of lightening keratinous tissue which comprise topically applying to the keratinous tissue in need of treatment a safe and effective amount of a composition comprising a safe and effective amount of an oxime compound and a dermatologically acceptable carrier for the oxime compound. More particularly, the present invention relates to methods of lightening skin, e.g., lightening hyperpigmented regions of skin, and of lightening skin by regulating melanin in skin, in the same manner as mentioned above.
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SUNSCREEN LOTION OR SPRAY COMPOSITION

(WO2001012146) 22.02.2001 A61K 8/04 PLAYTEX PRODUCTS, INC.
The present invention is a sunscreen composition that can interchangeably be used as a lotion or as a spray, without any change to the composition. The composition contains a sunscreen agent, a rheological additive, a pH adjuster, and water. Optionally, the sunscreen composition may include an emulsifier, an emollient, a moistening agent, a waterproofing agent, and a preservative.
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SKIN CARE COMPOSITION

(WO2001008652) 08.02.2001 A01N 27/00 UNILEVER PLC
A topical composition comprising: (a) conjugated linoleic acid and/or derivatives thereof; (b) a phenolic compound or mixtures thereof; and (c) a dermatologically acceptable vehicle; with the proviso that the phenolic compound is not a sunscreen. The product is particularly useful for treating wrinkles and soothing sensitive skin.
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SUNSCREEN AEROSOL COMPOSITION

(WO2001005366) 25.01.2001 A61K 8/04 PLAYTEX PRODUCTS, INC.
The present invention is a sunscreen composition in the form of an aerosol that foams. The composition contains a sunscreen agent, an emulsifier, a foam builder/stabilizer, a counterion, and a propellant. In addition, the ratio of the foam builder/stabilizer to counterion is about 1:4 to about 5:1.2 to ensure the foam quality and integrity.
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SUNSCREEN FOR THE SCALP AND HAIR

(WO2001005363) 25.01.2001 A61K 8/35 PLAYTEX PRODUCTS, INC.
The present invention is a sunscreen composition that protects the scalp and hair from the sun's rays. The composition contains at least one sunscreen agent in combination with a cinnamido alkyl amine cationic quaternary salt. In addition, a method for protecting the scalp and hair by applying an effective amount of the composition is provided.
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SUNSCREEN FORMULATIONS

(WO2001003663) 18.01.2001 A61K 8/04 H A MILTON HOLDINGS PTY LTD
The invention relates to an alcohol-based sunscreen formulation being a spray or gel comprising a hydrophobic fumed silica, a volatile silicone, an emollient, an effective amount of one or more sunscreening agents and an alcohol-based carrier vehicle.
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COSMETIC COMPOSITIONS

(WO2001000161) 04.01.2001 A61K 8/14 THE PROCTER &GAMBLE COMPANY
According to the present invention there is provided a cosmetic composition comprising: (a) at least one quaternary ammonium agent; and (b) at least one sunscreen active. The compositions of the present invention give sun protection benefits with low tackiness or stickiness. Moreover, the compositions of the present invention can give good skin care benefits with low levels of negatives such as greasiness, stickiness or tack.
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METHODS FOR TREATING SKIN WITH 3-HYDROXY BENZOIC ACID AND RELATED COMPOSITIONS

(WO2000074636) 14.12.2000 A61K 8/06 REVLON CONSUMER PRODUCTS CORPORATION
A method for improving and/or treating one or more conditions of the skin selected from the group consisting of texture, luminosity, radiance, fine lines, wrinkles, skin pigmentation irregularities, sallowness, and photodamage comprising applying to the skin a cosmetic composition comprising 0.01-30% by weight of the total composition of 3-hydroxybenzoic acid and the compositions used therefor.
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SILICONE GEL CONTAINING SALICYLIC ACID

(WO2000073374) 07.12.2000 A61K 8/04 NEUTROGENA CORPORATION
The present invention relates to a silicone gel comprising a volatile liquid, a silicone polymer, and salicylic acid; compositions comprising the silicone gel; and methods of using such gel and composition for the prevention and treatment of acne or seborrhea.
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SUNSCREEN COMPOSITION CONTAINING SOL-GEL MICROCAPSULES

(WO2000072806) 07.12.2000 A61K 8/11 SOL-GEL TECHNOLOGIES LTD
The present invention generally relates to safe and stable sunscreen compositions comprising at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens. The encapsulation also reduces or even prevents cross reactivity between the suscreen ...
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A METHOD FOR OBTAINING PHOTOSTABLE SUNSCREEN COMPOSITIONS

(WO2000071084) 30.11.2000 A61K 8/11 SOL-GEL TECHNOLOGIES LTD
The present invention relates to a method for obtaining improved photostability of a sunscreen composition that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the preparation of said composition. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in separate ...
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METHODS FOR UPREGULATING AND/OR MODULATING KGF PRODUCTION AND INCREASING RECEPTIVITY OF KERATINOCYTES TO KGF

(WO2000069409) 23.11.2000 A61K 7/48 THE PROCTER &GAMBLE COMPANY
The present invention relates to various methods for upregulating and/or modulating the production of keratinocyte growth factor wherein the methods each comprise the step of topically applying to the keratinous tissue of a host in need of such treatment a safe and effective amount of a composition comprising: a) a safe and effective amount of forskolin; and b) a dermatologically acceptable carrier for the forskolin. The present invention further relates to methods for increasing the receptivity of keratinocytes to KGF wherein the methods involve the same step as outlined above.
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METHODS OF REGULATING THE CONDITION OF MAMMALIAN KERATINOUS TISSUE

(WO2000069408) 23.11.2000 A61K 31/465 THE PROCTER &GAMBLE COMPANY
The present invention relates to various methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal in need of such treatment a safe and effective amount of a composition comprising: a) a safe and effective amount of a repair agent consisting essentially of a xanthine compound selected from the group consisting of theophylline, theobromine, and combinations thereof; and b) a dermatologically acceptable carrier for the repair agent. In particular embodiments, such compositions or modified versions thereof are suitable for regulating visible and/or tactile discontinuities in the texture of mammalian skin, preventing and/or retarding the a...
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METHODS FOR UPREGULATING AND/OR MODULATING KGF PRODUCTION AND INCREASING RECEPTIVITY OF KERATINOCYTES TO KGF

(WO2000069407) 23.11.2000 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to various methods for upregulating and/or modulating the production of keratinocyte growth factor wherein the methods each comprise the step of topically applying to the keratinous tissue of a host in need of such treatment a safe and effective amount of a composition comprising: a) a safe and effective amount of a compound effective for upregulating and/or modulating the production of keratinocyte growth factor; and b) a dermatologically acceptable carrier for the compound. The present invention further relates to methods for increasing the receptivity of keratinocytes to KGF wherein the methods involve the same step as outlined above. Preferably, the compound is a xanthine compound selected from the group co...
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METHODS OF REGULATING THE CONDITION OF MAMMALIAN KERATINOUS TISSUE

(WO2000069406) 23.11.2000 A61K 8/49 THE PROCTER &GAMBLE COMPANY
The present invention relates to various methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal in need of such treatment a safe and effective amount of a composition comprising: a) a safe and effective amount of a repair agent consisting essentially of forskolin; and b) a dermatologically acceptable carrier for the repair agent. In particular embodiments, such compositions or modified versions thereof are suitable for thickening skin and preventing and/or retarding atrophy in mammalian skin, regulating visible and/or tactile discontinuities in the texture of mammalian skin, preventing and/or retarding the appearance of spider vesse...
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METHODS FOR REGULATING THE CONDITION OF MAMMALIAN KERATINOUS TISSUE VIA TOPICAL APPLICATION OF PHYTOSTEROL COMPOSITIONS

(WO2000069404) 23.11.2000 A61K 8/63 THE PROCTER &GAMBLE COMPANY
The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of one or more phytosterols selected from the group consisting of $g(b)-sitosterol, campesterol, brassicasterol, $g(D)5-avennasterol, lupenol, $g(a)-spinasterol, stigmasterol, their derivatives, and combinations thereof; and b) a dermatologically acceptable carrier for the phytosterol. In additional embodiments, the above composition is suitable for thickening skin and preventing, retarding, and/or treating atrophy of mammalian skin, pr...
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METHOD OF IMPROVING THE AESTHETIC APPEARANCE OF EPITHELIA

(WO2000066077) 09.11.2000 A61K 8/67 AVON PRODUCTS, INC.
An effective treatment method for improving the appearance of epithelia, such as lip epithelia and vaginal epithelia is provided. According to the present method, an effective amount of a composition containing retinoid, preferably in a cosmetically acceptable carrier, is topically applied to the vaginal or lip epithelia. The present invention also includes compositions for practicing the method.
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ANTI-BACTERIAL COMPOSITION AND USE THEREOF FOR SKIN CARE AND FABRIC TREATMENT

(WO2000065911) 09.11.2000 A01N 25/34 SINTAL INTERNATIONAL, INC.
This invention relates to a water-based composition having at least one of anti-bacterial or anti-fungal properties and use thereof for skin care and for fabric treatment. The composition is not only effective as an anti-bacterial and/or anti-fungal material when included in a skin care gel or lotion for topical use, such as in a sun screen composition, or in conjunction with sanitary elastic gloves as a coating therein, it is gentle to the user's skin and may include constituents which advantageously indicate its presence. The composition is not only effective as an anti-bacterial and/or anti-fungal material when used as a liquid to treat fabric employed for personal hygiene aids including disposable diapers for children and adults, sanita...
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SKIN CARE COMPOSITIONS CONTAINING COMBINATION OF SKIN CARE ACTIVES

(WO2000062744) 26.10.2000 A61K 8/29 THE PROCTER &GAMBLE COMPANY
The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of farnesol; a safe and effective amount of bisabolol; a safe and effective amount of at least one additional skin care active; and a dermatologically acceptable carrier.
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SKIN CARE COMPOSITIONS CONTAINING COMBINATION OF SKIN CARE ACTIVES

(WO2000062743) 26.10.2000 A61K 8/29 THE PROCTER &GAMBLE COMPANY
The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of amount of a peptide active selected from the group consisting of pentapeptides, derivatives of pentapeptides, and mixtures thereof; a safe and effective amount of at least one additional skin care active; and a dermatologically acceptable carrier.
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METHODS FOR REGULATING THE CONDITION OF MAMMALIAN KERATINOUS TISSUE

(WO2000062742) 26.10.2000 A61K 8/29 THE PROCTER &GAMBLE COMPANY
The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. In additional embodiments, the above composition is suitable for thickening skin and preventing and/or retarding atrophy of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal, preventing and/or retarding sallown...
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SKIN CARE COMPOSITIONS CONTAINING COMBINATION OF SKIN CARE ACTIVES

(WO2000062740) 26.10.2000 A61K 8/29 THE PROCTER &GAMBLE COMPANY
The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of a vitamin B3 compound; a safe and effective amount of a skin care active selected from farnesol, phytantriol, and mixtures thereof; and a dermatologically acceptable carrier.
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PHOTOSTABLE SUNSCREEN COMPOSITIONS CONTAINING DIBENZOYLMETHANE DERIVATIVE, E.G., PARSOL 1789, AND DIESTERS OR POLYESTERS OF NAPHTHALENE DICARBOXYLIC ACID PHOTOSTABILIZERS AND ENHANCERS OF THE SUN PROTECTION FACTOR (SPF)

(WO2000057850) 05.10.2000 A61K 8/35 HAARMANN &REIMER
A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl) -4'- methoxydibenzoylmethane (PARSOL 1789), and a stabilizer for the dibenzoylmethane derivative having formula (I) or (II), or mixtures, wherein each R?1, same or different, is an alkyl group having 1 to 22 carbon atoms, a diol having the structure HO-R?2-OH, or a polyglycol having the structure HO-R?3-(O-R?2-)m?-OH, wherein R?2 and R?3, same or different, are each an alkylene group, straight chain or branched, having 1 to 6 carbon atoms, and wherein m and n are each 1 to about 100, or a mixture thereof. These diesters and polyesters of formula (I) or (II) are quite effective in stabilizing the dibenzoylmethane derivative...
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NON-STINGING COATING COMPOSITION

(WO2000056280) 28.09.2000 A61K 8/31 3M INNOVATIVE PROPERTIES COMPANY
Compositions comprising 1-40 % siloxane containing polymer; 60-99 % of an Alkane-Based Siloxy Polymer Reaction Solvent, and 0-15 % of adjuvants are useful for application to the skin or as components in cosmetic or topical medicament compositions.
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RESORCINOL COMPOSITION

(WO2000056279) 28.09.2000 A61K 8/02 PFIZER INC.
The present invention relates to the use of a resorcinol derivative as a skin lightening agent.
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SUNSCREEN COMPOSITION

(WO2000055348) 21.09.2000 A23L 1/275 UNILEVER PLC
A process for preparing protein- and/or peptide-bound melanin, which is soluble in an aqueous solution at pH 2 to 11 and temp 0 C to 50 C, comprising the steps of reacting dihydroxyphenylalanine with an oxidant enzyme in the presence of an acidic protein and/or peptide having a pI of 3-6. The soluble protein- and/or peptide-bound melanin of this invention is useful as a sunscreen and as a colouring and/or flavouring for food.
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PROCESS FOR PREPARING CYCLODEXTRIN INCLUSION COMPLEX

(WO2000054596) 21.09.2000 A01N 65/00 VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION
The present invention relates to a process for the preparation of a water soluble inclusion complex of neem seed kernel extract (NSKE) containing azadirachtin-A in a carrier molecule and its use in an insecticidal formulation. The process of the present invention comprises the following steps: adding neem seed kernel extract containing azadirachtin-A to the carrier molecule of the kind as herein described, the molar ratio of azadirachtin-A to the carrier molecule ranging from 1:0.5 to 1:20, stirring the above mixture, filtering the above mixture to obtain a water soluble inclusion complex of neem seed kernel extract, if desired, freeze/spray drying the said water soluble complex of neem seed kernel extract to get a free flowing pale cream p...
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REGULATING SKIN APPEARANCE AND COMPOSITION WITH A FLUORINATED VITAMIN D3? ANALOG COMPOUND

(WO2000051554) 08.09.2000 A61K 7/48 JOHNS HOPKINS UNIVERSITY
The present invention relates to topical skin care compositions and methods of their use. Such compositions comprise a fluorinated vitamin D3? analog which is useful for regulating skin condition, especially for regulating the signs of skin aging.
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COMPOSITIONS AND METHODS FOR PREVENTION OF PHOTOAGING

(WO2000050057) 31.08.2000 A61K 8/64 BERNSTEIN, Eric, F.
Methods of preventing photoaging and other types of sun damage by topically applying a composition containing a serine protease inhibitor or milk are provided. Pharmaceutical compositions comprising serine protease inhibitors or milk for the prevention of photoaging and other types of sun damage are also provided.
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PEST CONTROLLING

(WO2000048465) 24.08.2000 A01N 25/28 THIES TECHNOLOGY
The present invention features a sustained-release microcapsule for long-term pest controlling. In general, a microcapsule has a capsule core including active pest-control ingredients and diluents, and a capsule shell which physically separates the capsule core from the surrounding medium. Diluents are arranged to entrap active ingredients therein and to provide resistance to mass transfer of the active ingredients therethrough. The capsule shell generally includes the shell pores and provides additional resistance to mass transfer of the active ingredient therethrough. Diluents are selected from a class of material such that the mass transfer resistances existing in the capsule core and/or capsule shell depend on the temperature of the sur...
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DERIVATIZED MICROFIBRILLAR POLYSACCHARIDE

(WO2000047628) 17.08.2000 A61K 8/73 HERCULES INCORPORATED
A method for producing derivatized microfibrillar polysaccharide, including but not limited to cellulose, derivatized by steric and/or electrostatic forces, where the electrostatic forces are provided by anionic charge or by a combination of both anionic and cationic charge, by stabilizing and/or microfibrillating a polysaccharide starting material. A method of modifying the rheological properties of a composition of matter using derivatized microfibrillar polysaccharide. Method of improving coatings, paper manufacture, and the stability of emulsions, dispersions, and foams using a derivatized microfibrillar polysaccharide. Compositions that include derivatized microfibrillar polysaccharide, including paper compositions, comestible composit...
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CHOLESTEROL SULFATE COMPOSITIONS FOR ENHANCEMENT OF STRATUM CORNEUM FUNCTION

(WO2000045786) 10.08.2000 A61K 8/63 COLOR ACCESS, INC.
The present invention provides a method of retarding desquamation of the stratum corneum, and maintaining stratum corneum thickness, by applying to the skin an effective amount of cholesterol sulfate. The retardation of desquamation can be useful in enhancing the skin's own UV protection, in prolonging the retention time of a sunless tan, and generally reducing the appearance of lines and wrinkles associated with both photo- and chronoaging.
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PHOTOSTABLE UV PROTECTION COMPOSITIONS

(WO2000045784) 10.08.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to photostable compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency and broad spectrum UV efficacy while exhibiting improved photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) a photostabilizing system consisting essentially of an effective amount of 2-ethylhexyl-p-methoxycinnamate; and c) a suitable carrier; wherein the mole ratio of 2-ethylhexyl-p-methoxycinnamate to the dibenzoylmethane sunscreen active is from about 0.15:1 to about 1:1.
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A COMBINED INSECT REPELLENT AND SUNSCREEN COMPOSITION

(WO2000041672) 20.07.2000 A61K 8/27 RECKITT BENCKISER (AUSTRALIA) PTY LIMITED
A combined insect repellent and sunscreen composition is disclosed including 3-9 % by weight in total of at least two emulsifiers, based on the total weight of the composition. The composition preferably comprises titanium dioxide as the inorganic compound and N, N-diethyl-m-toluamide and dipropyl pyridine-2,5-dicarboxylate as insect repellents. A method of manufacturing a sunscreen composition is also disclosed. The composition including one or more insect repellents and one or more sunscreening agents, is the form of an emulsion having an oil phase and a water phase and is manufactured by preparing the oil phase and the water phase and combining to form an emulsion prior to the addition of at least one inorganic compound used as a sunscre...
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IMPROVED CONTROLLED RELEASE COMPOSITIONS AND METHOD

(WO2000041528) 20.07.2000 A61K 8/04 AMCOL INTERNATIONAL CORPORATION
A controlled release composition comprising an adsorbent polymer, an active agent, and a release retardant is disclosed. The composition has an improved ability to release the active agent over an extended time period.
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TOPICAL COMPOSITION COMPRISING N-ACETYLALDOSAMINES OR N-ACETYLAMINO ACIDS

(WO2000040217) 13.07.2000 A61K 8/60 YU, Ruey, J.
Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.
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SUNSCREEN COMPOSITIONS

(WO2000040214) 13.07.2000 A61K 8/06 UNILEVER PLC
A cosmetic sunscreen composition is provided which includes at least one organic sunscreen, a crosslinked non-emulsifying siloxane elastomer, a volatile siloxane and water. The composition is an oil-in-water emulsion to provide an aesthetically pleasing light skinfeel and rich viscosity, even in the presence of greater than 25 % sunscreen oils.
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COMPOSITIONS AND METHODS OF USING THE SAME

(WO2000038617) 06.07.2000 A01N 25/00 FOUR STAR PARTNERS
The present invention discloses compositions containing a one or more transfer agents and one or more barrier materials which form, upon application to a substrate, even a wet substrate or substrate immersed under water, adhesive, protective barriers. The compositions may be modified to provide an appropriate viscosity and other characteristics and may serve as a carrier for active agents.
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SKIN LIGHTENING COMPOSITION

(WO2000037039) 29.06.2000 A61K 8/36 UNILEVER PLC
A topical composition comprising: (a) conjugated linoleic acid, and/or derivatives thereof comprising conjugated linoleic acid moieties, in which at least 1 % by weight of the conjugated linoleic acid and/or moieties is present as the trans 10, cis 12 isomer, and (b) a dermatologically acceptable carrier. The product is particularly suitable for lightening human skin.
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SUNSCREEN COMPOSITION

(WO2000035414) 22.06.2000 A61K 8/35 UNILEVER PLC
A topical cosmetic sunscreen composition comprising (a) from 0.1 to 10% by weight of the composition of an ultra-violet radiation absorbing sunscreen dissolved in an oil; and (b) a cosmetically acceptable vehicle. A process for preparing such a composition is also described. The inventive composition has improved sunscreen efficacy.
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HYDROPHOBICALLY MODIFIED POLYSACCHARIDE IN ANHYDROUS ANTIPERSPIRANT PRODUCTS

(WO2000035412) 22.06.2000 A61K 8/34 HERCULES INCORPORATED
A solid stick, underarm product composition is composed of a liquid vehicle, an antiperspirant salt, a dibenzylidene alditol gelling agent, and a co-gelling agent of a hydrophobically modified water soluble polysaccharide polymer which comprises a water soluble polysaccharide polymer backbone, a hydrophobic moiety of C8?-C24? alkyl, aryl alkyl, alkyl aryl groups and mixtures thereof, wherein the hydrophobic moiety is present in an amount up to the amount which renders said polysaccharide less than 1 % by weight soluble in water, and dibenzylidene alditol, antiperspirant active and a liquid vehicle. This underarm product can be either clear or hazy.
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EMULSIFICATION SYSTEMS AND EMULSIONS

(WO2000033806) 15.06.2000 A61K 8/06 IMPERIAL CHEMICAL INDUSTRIES PLC
Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at low emulsifier stabiliser levels. The emulsifier stabiliser system provides stable emulsions without dominating system rheology, particularly viscosity. Thus, the emulsions can have a low viscosity suitable for formulation as milks or thin lotions, or can be thickened, desirably by thickening agents other than the Xanthan and/or polyglucomannan, to provide emulsion creams or gels. This enables the system to be used very flexibly in end use applications. The emulsifier is desirably a non-ionic emulsifier and particularly is a combination of a low HL...
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COMPOSITIONS WITH ENHANCED PHOTOPROTECTIVE EFFECT AND METHOD FOR USING SAME

(WO2000033803) 15.06.2000 A61K 8/29 COLOR ACCESS, INC.
The present invention relates to a sunscreen composition for topical application to the skin comprising a fluororesin having a submicron in combination with a sunscreen agent and an oil component. These compositions provide a boost in the SPF value of the composition. The invention also provides methods relating to the use of these compositions for boosting the SPF and decreasing the irritation on the skin caused by irritating sunscreen agents.
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COMPOSITIONS AND METHODS FOR CONTROLLING DEPOSITION OF WATER-INSOLUBLE INGREDIENTS

(WO2000033798) 15.06.2000 A61K 8/44 L'OREAL
A composition useful in a delivery system for water-insoluble ingredient(s) containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; and at least one cationic polymer, wherein the cationic polymer functions to control the amount of water-insoluble ingredient(s) deposited on keratinous substances. A method for treating keratinous substances with the compositions and delivery systems is also disclosed. In addition, the amount of water-insoluble ingredient(s) to be de...
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OIL BODIES AS TOPICAL DELIVERY VEHICLES FOR ACTIVE AGENTS

(WO2000030602) 02.06.2000 A61K 8/14 SEMBIOSYS GENETICS INC.
The present invention relates to the topical delivery of active agents, for example cosmetic compounds, to living organisms. In particular the present invention relates to the administration of therapeutically active agents in the presence of compositions obtainable from living cells known as oil bodies. The oil bodies of the present invention are especially suitable in applications where it is desired that the active agent is topically delivered. The oil bodies of the present invention are preferably obtained from oil seed plants.
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TOPICAL COMPOSITIONS INCLUDING DEODORANT COMPOSITIONS

(WO2000028958) 25.05.2000 A61K 31/60 TENDSKIN COMPANY
A topical composition for use in a variety of environments includes an active component, e.g., acetylsalicylic acid, a solvent mixture for the active components and, optionally, a silicone additive. The topical compositions according to the invention include nail hardeners, deodorants and sunscreen products.
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METHOD OF GENERATING AQUEOUS SILICA NETWORK PARTICLES AND COMPOSITIONS INCLUDING THE SILICA NETWORK PARTICLES

(WO2000028113) 18.05.2000 A61K 8/25 INTEGRITY TECHNOLOGIES, LLC
An aqueous composition including silica particles with a particle size distribution and particle structure that improve the water retention and exchange characteristics of the aqueous composition is provided. The aqueous silica composition includes silica network particles and water. The silica network particles comprise main particles and bridging particles that form chains between adjacent main particles. The main particles have a particles' size greater than the particle size of the bridging particles. Because of the presence of the silica network particles, the aqueous composition is capable of wetting a hydrophobic substrate more than pure liquid water. The silica network particles are generated in water by a method in which an aqueous...
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AZADIRACHTIN COMPOUNDS EXTRACTED FROM AZADIRACHTA INDICA, COMPOSITIONS AND USE THEREOF AS INSECTICIDAL

(WO2000024731) 04.05.2000 A01N 43/90 BADHEY, Mohan, R.
Storage stable azadirachtin, an insect repellent and insect growth regulator, and insecticidal formulations (emulsifiable concentrate) thereof, are prepared from purified neem kernel extract, with an active ingredient content of 0.3 % to 4 % and characterized by the absence of gums and aflatoxin spores, for example. The aforementioned formulations contain solvents belonging to the class of aliphatic dihydroxylated alcohols of more than 80 % by volume and optionally containing sunscreens and antioxidants.
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SOLAR RADIATION PROTECTION COMPOSITION

(WO2000024369) 04.05.2000 A61K 8/44 NOUVAB INC
The invention relates to sunscreen compositions for humans including naturally occurring sunscreen agents from plants, algae, cyanobacteria, fungi and bacteria that protect against exposure to solar radiation. The active sunscreen agents are compounds that naturally occur in plants, algae, cyanobacteria, fungi and bacteria and derivatives of these compounds.
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UV PROTECTION COMPOSITIONS

(WO2000023044) 27.04.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency, broad spectrum UV efficacy and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) an effective amount of a styrene derivative, having formula (I), wherein at least one of R1?, R2? and R3? is an electron-withdrawing substituent provided that R1? is other than an aryl and that R2? and R3? together do not form a camphor group; and R4? is selected from the group consisting of H, electron-donating substituents, and ele...
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UV PROTECTION COMPOSITIONS

(WO2000023043) 27.04.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency, broad spectrum UV efficacy, and photostability. Methods of use for these compositions are also disclosed. The compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) an effective amount of a tertiary amine containing 2 or less nitrogen atoms having formula (I) wherein R1?, R2?, and R3? are independently selected from the group consisting of straight, branched or cyclic C1?-C30? alkyls and aryls other than those aryls substituted in the para position with a benzofuran, carboxylic acid, or ester group; wherei...
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UV PROTECTION COMPOSITIONS

(WO2000023042) 27.04.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency, broad spectrum UV efficacy, and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) and an effective amount of a naphthalene derivative having formula (I) wherein R is in the 1 or 2 positions and is independently selected from the group consisting of CHO, COOH, COR' wherein R' is a C1?- C30? straight or branched alkyl or an aryl, and wherein said naphthalene derivative has a triplet energy state of from about 56 kcal/mol to ...
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UV PROTECTION COMPOSITIONS

(WO2000023041) 27.04.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The compositions provide excellent efficiency, broad spectrum UV efficacy, and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of UVA-absorbing dibenzoylmethane sunscreen active; b) an effective amount of an aniline derivative, having formula (I) wherein R1?, R2?, R3?, R4? and R5? are independently selected from the group consisting of H, R', OR', COOH, CHO, COOR', CN, SO2?R', SO2?OR', NO, aryls, OH, SH, NHR', NR'2?, SR', I, Cl, F, Br, and combinations thereof; wherein R' is a C1? - C30? straight or branche...
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ALKOXYLATED FATTY ALCOHOL DICARBOXYLIC ACID ESTERS

(WO2000019972) 13.04.2000 C07C 67/00 CRODA, INC.
Fatty alkoxylated esters consisting of diesters of aliphatic or aromatic dicarboxylic acids, formed by reacting the acid with a stoichiometric excess of one or more polyalkoxylated fatty alcohols. Non-aqueous compositions for topical application are also disclosed including one or more active ingredients, and an emollient agent of the fatty alkoxylated esters of the present invention.
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COMPOSITIONS HAVING A SUNSCREEN FOR USE IN PERSONAL CLEANSING PRODUCTS

(WO2000018367) 06.04.2000 A61K 8/27 AVON PRODUCTS, INC.
The present invention relates to personal cleansing compositions that provide effective sunscreen protection. The composition is used to make personal cleansing products such as cleansing bars, face and body washes, shower gels and shampoos that provide cleansing activity and sunscreen protection.
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USE OF ISOPARAFFIN EXTENDERS FOR CLEAR GEL COSMETIC COMPOSITIONS

(WO2000015191) 23.03.2000 A61K 8/58 EXXON CHEMICAL PATENTS INC.
A clear cosmetic gel composition comprising: (a) an aqueous phase comprising: (i) water, and (ii) at least one cosmetically active ingredient; (b) a coupling agent; (c) an oil phase comprising: (i) a silicone-containing solvent, and (ii) an isoparaffin solvent having a boiling range between about 100 to 340 C, wherein the isoparaffin constitutes between about 1 to 75 % by weight, of the total of the oil phase; and (d) silicone-containing surfactant.
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HAIR CARE COMPOSITIONS COMPRISING CERAMIDE AND PHYTANTRIOL

(WO2000015181) 23.03.2000 A61K 8/68 UNILEVER PLC
Composition for the treatment and protection of hair, comprising, in a cosmetically acceptable medium, at least one ceramide and/or glycoceramide and phytantriol.
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METHOD AND COMPOSITIONS FOR REDUCING DERMATOLOGICAL AGING AND FOR REDUCING BRUISING

(WO2000013661) 16.03.2000 A61K 8/35 AVON PRODUCTS, INC.
Methods to reduce susceptibility to, severity or duration of, bruising of skin and topical compositions for practicing such methods. The topical compositions comprise an isoflavonoid and a vehicle. The invention also includes a synergistic topical composition that includes, in addition to the isoflavonoid and vehicle, secondary components selected from specific classes of compounds.
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MAKEUP COMPOSITIONS AND METHODS OF MAKING SAME

(WO2000012053) 09.03.2000 A61K 8/04 AMWAY CORPORATION
Makeup compositions having enhanced transfer resistance including at least one hydrophilic film former. The makeup can be a water-in-oil emulsion having the hydrophilic film former in the internal water phase and at least one pigment in the external oil phase. The makeup composition can also be a suspension of one or more cationically-coated pigments in water in which the hydrophilic film former is dissolved. The hydrophilic film former may also be an anionic gelling agent, whereby the cationically-coated pigment and the anionic gelling agent form a water-dispersable complex that upon application to the skin forms an insoluble pigmented salt having enhanced transfer resistance.
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COSMETIC COMPOSITION

(WO2000009082) 24.02.2000 C11D 1/28 UNILEVER PLC
An anhydrous foaming cleansing composition for topical application to the human skin, comprising an anionic surfactant, glycerine, polyethylene glycol, and a water insoluble benefit agent.
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PERSONAL CLEANSING COMPOSITIONS HAVING PHOTOPROTECTIVE AGENTS

(WO2000009081) 24.02.2000 A61K 8/27 SKINNOVATIVE DERMATOLOGIC CONCEPTS, L.L.C.
A composition for use as a sunscreen applied during washing includes photoprotective agents of the organic type (e.g., octylmethoxy cinnamate and oxybenzone), the inorganic type (e.g., titanium dioxide and zinc oxide), or combinations of the organic and inorganic agents. Additional components include skin penetration enhancers, emollients and surfactants. Additional sunscreen combinations include a sunscreen cleanser based upon triethanolamine (TEA).
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TOPICAL LOTION CONTAINING OATSTRAW

(WO2000007556) 17.02.2000 A61K 8/97 MIGNAULT, Lorraine
A topical lotion for relief from pain, swelling and itch composed of natural ingredients is herein described. The lotion is composed of a mixture of an oatstraw concentrate and glycerine. The lotion is used to treat a variety of skin conditions as well as injuries such as herniated discs, muscle, tendon and ligament pulls and tears. Furthermore, topical application of the lotion to the scalp has been shown to stop hair loss in some instances and in fact promote hair growth. The lotion can also be applied to the soles of the feet as a way of inducing a deeper and more restful sleep in an individual.
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STABILIZED ASCORBIC ACID, COMPOSITION, AND METHOD OF USE

(WO2000006155) 10.02.2000 A61K 47/06 SUNSMART, INC.
A dispersion for carrying at least one water-soluble material or water-dispersible material (especially ascorbic acid, Vitamin C) in a relatively stable form is described, the dispersion comprising an oil phase containing particles comprising water-soluble polymer, water-soluble material or water-dispersible material (ascorbic acid), and water. The dispersion preferably comprises particles which have number average diameter dimensions of less than 2 microns, more preferably less than 1 micron. The dispersion may comprise oil components such as, for example only, a mineral oil, silicone oil, or cosmetic oil. A method of forming a dispersion of solid particles which comprise water-soluble material or water-dispersible material (e.g., ascorbic...
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SUNSCREEN COMPOSITIONS

(WO2000006112) 10.02.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for use as sunscreens which have improved storage stability and improved retention of UV absorbance capability. Methods of using the compositions are also disclosed. The compositions comprise an emulsion comprising a safe and effective amount of a UVA-absorbing dibenzoylmethane sunscreen active in one or more oil phases, a safe and effective amount of a formaldehyde donor preservative in one or more aqueous phases, and an emulsifier.
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SUNSCREEN COMPOSITIONS

(WO2000006111) 10.02.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for use as sunscreens which comprise a UVA sunscreen active and a carrier suitable for application to the skin. These compositions are substantially free of benzylidene camphor derivatives and provide excellent stability, efficiency, and UV protection efficacy in a safe, economical and aesthetically appealing manner. The compositions have a Sunscreen Efficiency Index of at least about 1.75, a UVA Efficacy Value of at least about 0.5, a UVA Photostability Index of at least about 0.85, a UVB Photostability Index of at least about 0.85, and a Transparency Value of less than about 10. Methods of using the compositions are also disclosed.
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SUNSCREEN COMPOSITIONS

(WO2000006110) 10.02.2000 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions suitable for use as sunscreens which provide excellent stability, efficiency, and UV protection efficacy in a safe, economical and aesthetically appealing manner (on-skin transparency, low skin irritation). Methods of use for these compositions are also disclosed. The compositions comprise: a) a safe and effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) a safe and effective amount of a stabilizing agent having formula (I) wherein R1? and R1'? are independently in the para or meta position and are independently a hydrogen atom or a straight- or branched chain C1?-C8? alkyl radical, R2? is a straight- or branched-chain C1?-C12? alkyl radical; and R3? is a hy...
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POLYMERIC COMPOUNDS AND METHODS OF FORMULATING SAME

(WO2000003723) 27.01.2000 A01N 35/02 CHEMEQ LIMITED
A method for the preparation of compositions of poly(2-propenal, 2-propenoic acid), whereby the compositions exhibit one or more of the properties of increased stability, increased antimicrobial activity, reduced trans-dermal migration of low molecular weight components of the composition, and the formation of continuous antimicrobial film on substrates, the property or properties making the composition suitable for one or more of antimicrobial use, dermatological use, and/or use as an animal feed additive.
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SKIN WHITENING COMPOSITION

(WO2000000162) 06.01.2000 A61K 8/27 AVON PRODUCTS, INC.
The composition has a skin whitening blend. The skin whitening blend has a hypopigmenting component and an antioxidant. The skin whitening blend may also have a component responsible for enhancing or accelerating the skin cell turnover rate that is selected from the group consisting of: lactic acid; glycolic acid; a mixture of lactic acid and glycolic acid; and a blend of lactic acid, malic acid and citric acid. The skin whitening blend may also comprise the hypopigmenting component, the antioxidant and a sunscreen, and the accelerant component.
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SUN SCREEN FORMULATIONS

(WO1999066896) 29.12.1999 A61K 8/42 CIBA SPECIALTY CHEMICALS HOLDING INC.
Disclosed is sun screen formulation, comprising (a) a micronised organic UV absorber; and (b) a cosmetically acceptable carrier, wherein the micronised organic UV absorber is present in the oil phase of the formulation. The sunscreen composition of the invention provides excellent protection of the human skin against the damaging effects of sunlight, while permitting safe tanning of the skin.
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PERSONAL WASHING COMPOSITIONS

(WO1999063965) 16.12.1999 A61K 8/11 UNILEVER PLC
A personal washing composition containing a) surfactant selected from anionic, nonionic, zwitterionic and cationic surfactants, soaps and mixes thereof; b) polymeric deposition aid; c) encapsulated sunscreen.
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STABLE GEL MIXTURE IN THE FORM OF A MIXTURE OF OLEOGEL AND AQUEOUS GEL

(WO1999062497) 09.12.1999 A61K 9/06 AIACHE, Jean-Marc
ohe present invention relates to a stable gel mixture, having a substantially uniform appearance, which stable gel mixture comprises at least one oleogel and of at least one aqueous gel, the oleogel comprising at least one oily agent gelled with at least one cellulose polymer. The present invention also relates to a pharmaceutical composition comprising this gel, to the use of this pharmaceutical composition as a reservoir for active ingredients in a transdermal release system, as well as to a cosmetic composition comprising this gel. This gel has remarkable stability and a fresh and pleasant feel.
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SUNSCREEN COSMETIC COMPOSITION

(WO1999062476) 09.12.1999 A61K 8/29 UNILEVER PLC
A sunscreen cosmetic composition is provided which is a water and emollient oil emulsion containing an inorganic sunscreen agent such as titanium dioxide with a relatively large particle size ranging from about 0.1 to 20 micron and an organic sunscreen agent. High levels of sunscreen activity are achievable without any significant adverse effect on emulsion aesthetics.
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SUNSCREEN WITH DISAPPEARING COLOR INDICATOR

(WO1999060995) 02.12.1999 A61K 8/35 SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.
A colored sunscreen emulsion which enables the user to more effectively protect against skin damage, by facilitating more complete and uniform coverage of the sunscreen on the skin, comprises: a) at least one particulate ultramarine pigment that imparts a color other than white to the sunscreen emulsion, in amounts such that when the sunscreen emulsion is rubbed into the skin, the color substantially disappears; b) at least one sunscreen active agent in an amount effective to protect skin against the actinic radiation of the sun; c) at least one emulsifier; d) sufficient water to form the colored emulsion; and e) optionally, one or more ingredients from one or more of the following classes: emollients, humectants, dry-feel agents, waterproo...
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ULTRAVIOLET LIGHT SCREENING COMPOSITIONS

(WO1999060994) 02.12.1999 A61K 8/11 ISIS INNOVATION LIMITED
A UV screening composition comprising particles which are capable of absorbing UV light so that electrons and positively charged holes are formed within the particles, characterised in that the particles are adapted to minimise migration to the surface of the particles of the electrons and/or the positively charged holes when said particles are exposed to UV light in an aqueous environment.
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SUNSCREEN HAVING DISAPPEARING COLOR INDICATOR

(WO1999056718) 11.11.1999 A61K 8/06 SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.
A colored sunscreen emulsion which enables the user to more effectively protect against skin damage, by facilitating more complete and uniform coverage of the sunscreen on the skin, comprises: a) at least one oil-soluble dye that imparts a color other than white to the sunscreen, in amounts such that when the emulsion is rubbed into the skin, the color substantially disappears; b) at least one sunscreen active agent in an amount effective to protect skin against the actinic radiation of the sun; c) at least one emulsifier; d) sufficient water to form the colored emulsion; and e) optionally, one or more ingredients from one or more of the following classes: emollients, humectants, dry-feel agents, waterproofing agents, preservatives, antioxi...
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SKIN WHITENING COMPOSITION

(WO1999055352) 04.11.1999 A61K 8/27 AVON PRODUCTS, INC.
The composition has a skin whitening blend. The skin whitening blend has a hypopigmenting component and an antioxidant. The skin whitening blend may also have an accelerant that enhances or accelerates the skin cell turnover rate. The skin whitening blend may also comprise the hypopigmenting component, the antioxidant and and a sunscreen, or all three ingredients and the accelerant.
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METHOD OF TREATING THE SKIN WITH ORGANIC ACIDS IN ANHYDROUS POLYMERIC DELIVERY SYSTEMS

(WO1999055307) 04.11.1999 A61K 9/16 AVON PRODUCTS, INC.
There is provided a method of treating skin with a therapeutic, water-soluble organic acid. There is also provided an anhydrous composition composition containing the water-soluble organic acid encapsulated into hydrophobic microspheres through which the oranic acid can elute in the presence of water is applied to the skin. The composition is wet with water immediately prior to, or after the composition is applied to the skin.
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CLEANSING ARTICLES FOR SKIN AND/OR HAIR WHICH ALSO DEPOSITS SKIN CARE ACTIVES

(WO1999055303) 04.11.1999 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a substantially dry, disposable, personal cleansing article useful for both cleansing the skin or hair and delivering skin care actives onto the skin or hair. These articles are used by the consumer by (i) wetting the dry article with water and (ii) generating lather by subjecting the wetted article to mechanical forces, e.g., rubbing. The article comprises a water insoluble substrate, a lathering surfactant, and a skin care active component. Preferably, the articles of the present invention further comprise a deposition aid and/or a conditioning component.
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DETERGENT COMPOSITIONS

(WO1999051716) 14.10.1999 A61K 8/02 UNILEVER PLC
An aqueous detergent composition, which is in the form of a thickened, mobile fluid, comprising foaming detergent and a polymer or polymer mixture which is capable of forming a reversible gel, which polymer or mixture is present in the composition as a multiplicity of individual gel particles.
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METHOD OF REDUCING CELLULITE IN MAMMALIAN SKIN

(WO1999047112) 23.09.1999 A61K 8/67 THE PROCTER &GAMBLE COMPANY
The present invention relates to a method for combating cellulite or reducing localized fatty excesses which comprises administering to a person having cellulite or localized fatty excesses a body slimming amount of a composition containing niacinamide.
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OPALESCENT COSMETIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION

(WO1999038487) 05.08.1999 A61K 31/74 ESTEE LAUDER, INC.
The present invention relates to opalescent cosmetic compositions that are stable and suitable for topical application to human skin, and to methods for preparing and using such compositions. The compositions of the invention include (1) a hydrogenated indenestyrene-vinyltoluene polymer in an amount from about 0.1 % by weight to about 50 % by weight of the composition and (2) a carrier material in an amount from about 50 % by weight to about 99.9 % by weight of the composition. The opalescent composition may further contain a cosmetic material in an amount from about 0.5 % by weight to about 20 % by weight of the composition.
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SKIN CARE COSMETIC METHOD AND SYSTEM

(WO1999037281) 29.07.1999 A61K 8/02 UNILEVER PLC
A cosmetic system and method for delivering a compound having an octanol/water coefficient log P in the range of from -2 to 6 to the skin. Also disclosed is a cosmetic method and system for protecting the skin from UV ray damage, after the skin has been stripped with an adhesive composition.
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PHOTOSTABLE UV ABSORBENT CONTAINING $g(a)-CYANO CINNAMYL MOIETY

(WO1999036049) 22.07.1999 A61K 8/40 ISP INVESTMENTS INC.
A photostable UV absorbent with maximum absorption above 340 nm having formula (I), wherein R is -CO(R2?) or phenyl optionally substituted with lower alkyl and/or lower alkoxy; R2? is -alkyl, -O(C2+? alkyl), (1) or (2); n has a value of from 2 to 8; S and T each independently are hydroxy, lower alkyl, lower alkoxy or, when R2? is alkyl or alkoxy, S can also be phenyl and when R2? is alkoxy, T is alkoxy, or S + T taken with the phenyl ring form a naphthyl radical or a fused benzodioxol-5-yl heterocyclic radical; k + 1 has a value of from 0 to 3 with the proviso that, when R2? is -O(alkyl), T is -O(lower alkyl) and the value of 1 is 2 or 3; R3? is hydrogen or lower alkylene; R4?, R5?, and R6? are each independently C1? t...
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COMPOSITION WITH HIGH EFFICIENCY SKIN PROTECTION FROM DAMAGING EFFECTS OF ULTRAVIOLET LIGHT

(WO1999033439) 08.07.1999 A61K 8/42 SHAKLEE CORPORATION
A topical antioxidant composition for the protection of skin from damage caused by ultraviolet radiation. The composition includes a first component (such as beta glucan or grape seed extract) that increases cellular viability of epidermal cells, and a second component that decreases the production of inflammatory mediators, such as prostaglandins, in those cells. In a particular embodiment, the composition includes beta glucan in combination with panthenol, grape seed extract, vitamin C and superoxide dismutase, which exhibit a synergistic effect in protecting the skin from the adverse effects of ultraviolet radiation. In another embodiment, the composition further includes Vitamin A and Vitamin E. In a further embodiment, the composition ...
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COSMETIC MAKEUP COMPOSITION

(WO1999030681) 24.06.1999 A61K 8/06 NEOSTRATA COMPANY, INC.
A water-in-silicone cosmetic makeup composition includes a hydroxy acid, a sunscreen agent, a moisturizing agent, an antioxidant, a cosmetically acceptable pigment, an emulsifier, a silicone-containing compound and water. The composition when applied to the skin protects the skin from ultraviolet light exposure, and it reduces the appearance of fine lines and wrinkles. The composition also is highly moisturizing and gentle enough for sensitive skin. Methods of protecting the skin from ultraviolet light exposure and reducing the appearance of fine lines and wrinkles by topically applying this composition, as well as methods of making the emulsified compositions also are disclosed.
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CLEANSING COMPOSITION CONTAINING POLYMERIC GELLANT

(WO1999028429) 10.06.1999 A61K 8/90 BUSH BOAKE ALLEN CORPORATION
Cleansing compositions, such as bar soaps and liquid soaps, particularly for personal use, are prepared from a polymeric gellant and a surfactant. The polymeric gellant is a block copolymer, such as a diblock or triblock copolymer. The cleansing composition preferably contains a solvent which, in combination with the gellant, forms a gel. Hydrocarbons are preferred solvents. The cleansing composition may contain optional ingredients such as fragrance and emollients.
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HIGH MOLECULAR WEIGHT POLYMER ADDITIVE FOR COATING AND LUBRICATING PRODUCTS

(WO1999027039) 03.06.1999 C10M 143/06 GENERAL TECHNOLOGY APPLICATIONS, INC.
An ultrahigh molecular weight polymer, such as ultrahigh molecular weight polyisobutylene, is used as an additive to enhance the lubricating/coating properties of a solvent. The polyisobutylene has a molecular weight of at least 2.5 - 3.0 million daltons, preferably greater than about 6 daltons, and is provided in a preferred concentration of 0.05 to 0.3 %. The solvent can be a medicinal grade mineral oil. Other suitable solvents include hydrocarbon oil and low viscosity, synthetic compositions. In all cases, the lubricating/coating properties of the solvent are greatly enhanced by the addition of ultrahigh molecular weight polyisobutylene. In another aspect of the invention, ultrahigh molecular weight polyisobutylene is used as an additive...
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COMPOSITION COMPRISING ONE OR MORE FLAVONOIDS, METHOD OF OBTAINING SUCH COMPOSITION AND USE THEREOF AS UV-ABSORBING AGENT

(WO1999025316) 27.05.1999 A61K 8/49 FLAVONE SUNPRODUCTS A/S
The present invention relates to a method of obtaining a composition comprising one or more flavonoids, a composition comprising one or more flavonoids obtainable by said method, and a sunscreen product comprising a composition comprising one or more flavonoids. The method of preparing the composition comprising one or more flavonoids comprises the steps of treating a flavonoid containing raw material with an aqueous extraction medium to obtain an extract and separating the flavonoids from said extract by absorption and/or adsorption.
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COMPOSITIONS CONTAINING COMBINATIONS OF SOLID POLYOL FATTY ACID POLYESTERS AND A SOLID OIL

(WO1999024010) 20.05.1999 A61K 7/48 THE PROCTER &GAMBLE COMPANY
Disclosed are compositions suitable for topical application to human hair or skin, which comprise a combination of a solid polyol fatty acid polyester having a melting point of from about 30 C to about 80 C, and a solid oil other than a solid polyol fatty acid polyester having a melting point of from about 30 C to about 250 C, wherein said solid polyol fatty acid polyester has a polyol moiety and at least 1 fatty acid moiety, the polyol moiety having at least 4 free hydroxyl groups wherein at least 60 % of these free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms. The composition preferably further comprises a topical carrier for the solid polyol fatty acid polyester ...
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SUN PROTECTIVE BODY CLEANSER COMPOSITION

(WO1999024008) 20.05.1999 A61K 8/27 KAUFMAN, Stacy, R.
Disclosed in a body cleansing composition providing upon a single application protection against sunburn measured by Sun Protection Factor (SPF) of at least 15 as applied and SPF of at least 4, and preferably at least 5, after rinsing, consisting essentially of water; at least one first sunscreen compound which is a paramethoxycinnamate ester, and at least one second sunscreen compound able to absorb at least 50 % of incident radiation at wavelengths from 290 to 320 nanometers; a combination of at least two surface active agents including a first anionic agent which can be an alkyl sulfate salt or an alkoxylated alkyl sulfate salt, and a second agent which can be nonionic, anionic or zwitterionic; at least one hydroxyethylated organic nitro...
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COMPOSITIONS CONTAINING COMBINATIONS OF LIQUID POLYOL FATTY ACID POLYESTERS AND A LIQUID OIL

(WO1999024003) 20.05.1999 A61K 8/04 THE PROCTER &GAMBLE COMPANY
Disclosed are compositions suitable for topical application to human hair or skin, which comprise (a) from about 0.1 % to about 99.9 % by weight of a liquid polyol fatty acid polyester having a melting point of from about -30 C to about 30 C, wherein the liquid polyol fatty acid polyester has a polyol moiety and at least 1 fatty acid moiety, the polyol moiety having at least 4 free hydroxyl groups wherein at least 60 % of these free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms; and (b) from about 0.1 % to about 99.9 % by weight of a liquid oil having a melting point of from about -30 C to less than about 30 C, wherein the liquid oil is subtantially free of liquid po...
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ANTIMUTAGENIC COMPOSITIONS FOR TREATMENT AND PREVENTION OF PHOTODAMAGE TO SKIN

(WO1999022741) 14.05.1999 A61K 31/70 PRO-NEURON, INC.
A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
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CLEANSING AND CONDITIONING ARTICLE FOR SKIN OR HAIR HAVING IMPROVED FRAGRANCE DELIVERY

(WO1999021532) 06.05.1999 A61K 8/02 THE PROCTER &GAMBLE COMPANY
The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and conditioning the skin/hair and providing improved fragrance delivery. These articles are used by the consumer by wetting the dry article with water. The article comprises a water insoluble substrate, a lathering surfactant, and a fragrance-releasing complex. Preferably, the articles of the present invention further comprise a conditioning component. Use of the substrate enhances lathering at low surfactant levels, increases cleansing and exfoliation, optimizes delivery and deposition of conditioning ingredients, and provides desirable characteristics such as texture, thickness and bulk. As a result, this invention provi...
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SUNSCREEN COMPOSITION

(WO1999015144) 01.04.1999 A61K 8/27 THE B.F.GOODRICH COMPANY
Disclosed are sunscreen compositions comprising zinc oxide and at least one of an effective amount of carbomer and an effective amount of C10? to C30? alkyl acrylate crosspolymers. The compositions most preferably utilize an oil in water emulsion. Also disclosed are related processes for producing and using such compositions.
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HAIR STYLING COMPOSITIONS

(WO1999015135) 01.04.1999 A61K 8/19 THE PROCTER &GAMBLE COMPANY
The present invention relates to hair styling compositions comprising water soluble, non-polymeric mineral salts and lipophilic materials which provide improved hair styling. Specifically, the present invention relates to hair styling compositions comprising water soluble, non-polymeric mineral salts and lipophilic materials further comprising low levels of a dispersing surfactant for improved hair styling.
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PREPARATION WITH DISPENSING MEANS

(WO1999013760) 25.03.1999 A47K 10/38 NUC-ONE ENTERPRISES PTY. LTD.
A preparation (9) is impregnated in a tissue (5) which is of substantially constant width along its length, wound in the form of a roll (6) and located in a container (1) with a first end (8) of the tissue (5) protruding from the centre of the roll (6) adjacent to a lid (2) and having a plurality of weakened areas (10) spaced along its length; the lid (2) comprises an opening (7) which is adapted to resist pulling of the tissue (5) through the opening (7) by a user to that the preparation (9) impregnated in the tissue (5) is substantially retained in the tissue (5) as the tissue (5) is pulled through the opening (7) and the tissue (5) so pulled separates at a weakened area (10) and a part of the tissue (5) is thereby dispensed to the user; ...
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METHOD FOR TREATING CHAPPED LIPS

(WO1999009936) 04.03.1999 A61K 8/37 REVLON CONSUMER PRODUCTS CORPORATION
A method for preventing, retarding, arresting, or reversing the effects of chafed, chapped, cracked, or windburned lips comprising applying to the lips a pigmented lipstick composition comprising, by weight of the total composition: 0.01-30 % skin protectant selected from the group consisting of allantoin, cocoa butter, dimethicone, glycerin, petrolatum, shark liver oil, and mixtures thereof, 1-25 % pigment, 5-80 % of an oil selected from the group consisting of nonvolatile oil, volatile oil, and mixtures thereof, and 3-40 % of a wax having a melting point of 30 to 135 C.
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SKIN CARE COMPOSITIONS AND USE

(WO1999008651) 25.02.1999 A61K 31/20 SCANDINAVIAN-AMERICAN IMPORT/EXPORT CORPORATION
The invention provides compositions containing dermaphile oils and methods for their use. Preferred composition contain Purcellin Oil and are useful in treating a wide variety of adverse skin conditions, including disorders manifesting inflammatory and non-inflammatory symptoms and having a variety of etiologies. The compositions are especially useful in treating psoriasis, eczema, acne, surgical scars and sunburn, but are also useful in treating cuts, insect bites, pruritis, cold sores and dry skin. Methods for the use of these compositions are also provided.
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PHOTORESPONSIVE SUNSCREEN COMPOSITIONS

(WO1999007336) 18.02.1999 A61K 8/42 CALIFORNIA INSTITUTE OF TECHNOLOGY
The disclosure provides sunscreen compositions comprising a carrier for topical administration and photoresponsive first sunscreen agents which are capable of undergoing intramolecular photorearrangements to form second sunscreen agents. The second sunscreen agents absorb more ultraviolet radiation than the first sunscreen agents. The sunscreen composition may comprise the prephotorearrangement first sunscreen agent, the photorearranged second sunscreen agent, a combination of the first and second sunscreen agents, or any of the above in combination with a known sunscreen agent.
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COSMETIC COMPOSITION CONTAINING SILOXANE-BASED POLYAMIDES AS THICKENING AGENTS

(WO1999006473) 11.02.1999 A61K 8/895 COLGATE-PALMOLIVE COMPANY
An invention is disclosed which comprises siloxane-based polyamides as gelling agents for cosmetic products, methods for making such agents, formulations thereof and cosmetic formulations therewith. These polyamides contain siloxane groups in the main chain and act to thicken compositions containing volatile and/or non-volatile silicone fluids. Cosmetic compositions may be made by adding at least one active ingredient such as an antiperspirant.
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LIQUID DETERGENT COMPOSITIONS AND PROCESS FOR THEIR PREPARATION

(WO1999003963) 28.01.1999 C11D 3/42 UNILEVER PLC
An aqueous liquid detergent composition is substantially transparent in the absence of opacifier contains a sunscreen together less than 5 wt.% of detergency builder and/or comprises a water-miscible polar organic solvent. The solvent and fluorescer or ultraviolet absorbing agent are mixed together as a premix prior to incorporation in the composition as a whole.
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A SKIN CARE AND PROTECTION COMPOSITION AND A METHOD FOR PREPARATION THEREOF

(WO1999002128) 21.01.1999 A61K 8/96 DEAD SEA LABORATORIES LTD.
The present invention generally relates to a composition useful for care of skin conditions and for skin protection and to a method for its preparation. the present invention further relates to a method for skin care and protection using said composition. More specifically, the present invention relates to a composition combining plant and algae extracts with water solutions from the Dead Sea especially useful for treating skin wrinkles and retaining skin moisture, to a method for the prepartion thereof and to a method for skin care and protection comprising dermal application of said composition.
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AQUEOUS CARRIER SYSTEMS FOR WATER-INSOLUBLE MATERIALS

(WO1998056333) 17.12.1998 A61K 8/44 L'OREAL
A composition containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; and at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid. The invention also relates to a delivery system for water-insoluble ingredients containing the above components, at least one water-insoluble ingredient, and an aqueous phase, wherein the organic phospholipid, amphoteric surfactant, and nonionic surfactant are present in a combined amount sufficient to allow the water-insoluble ingredient to be incorporated into the system. A method of treat...
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COMPOSITIONS CONTAINING SELECT SOLID POLYOL FATTY ACID POLYESTERS

(WO1998052531) 26.11.1998 A61K 8/37 THE PROCTER &GAMBLE COMPANY
Disclosed are compositions suitable for topical application to human hair or skin, which comprise a combination of a solid polyol fatty acid polyester having a melting point of from about 30 C to about 80 C, and a liquid oil other than a solid polyol fatty acid polyester having a melting point of less than about 30 C to about - 30 C, wherein said solid polyol fatty acid polyester has a polyol moiety and at least 1 fatty acid moiety, the polyol moiety having at least 4 free hydroxyl groups wherein at least 60 % of these free hydroxy groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms. The composition preferably further comprises a topical carrier for the liquid polyol fatty acid pol...
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COMPOSITIONS CONTAINING SELECT LIQUID POLYOL FATTY ACID POLYESTERS

(WO1998052528) 26.11.1998 A61K 6/00 THE PROCTER &GAMBLE COMPANY
Disclosed are compositions suitable for topical application to human hair or skin, which comprise a combination of a liquid polyol fatty acid polyester having a melting point of from about -30 C to about 30 C, and a solid oil other than a solid polyol fatty acid polyester having a melting point of above about 30 C to about 250 C, wherein said liquid polyol fatty acid polyester has a polyol moiety and at least 1 fatty acid moiety, the polyol moiety having at least 4 free hydroxyl groups wherein at least 60 % of these free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms. The composition preferably further comprises a topical carrier for the liquid polyol fatty acid polye...
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SUNSCREEN COMPOSITION

(WO1998052525) 26.11.1998 A61K 8/27 SOLTEC RESEARCH PTY. LTD.
The invention provides a sunscreen formulation including conventional UVB sunscreening agents and zinc oxide having an average particle size in the order of 150 to 800 nm. Preferably the zinc oxide used is pigment grade. Most preferably, zinc oxide prepared by the French process is used, although that produced by the American process is also suitable. The average particle size of the zinc oxide is most preferably in the order of 200-400 nm. Throughout this specification, the term 'pigment grade' is used to define zinc oxide that has been produced by the French or American process. A further embodiment of the invention is a method of reducing or preventing the harmful effects of solar radiation on skin by applying the inventive sunscreen for...
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COMPOSITIONS FOR COSMETIC APPLICATIONS

(WO1998050005) 12.11.1998 A61K 8/02 MEDLOGIC GLOBAL CORPORATION
A cosmetic composition is described having a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.
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COSMETIC PARTICULATE GEL CARRIERS FOR TOPICALLY APPLIED ACTIVE AGENTS

(WO1998050000) 12.11.1998 A61K 8/73 KOBO PRODUCTS, INC.
Crushable gel beads (10) formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads (10) are complexes of a continuous phase of agar gel (12) in a self-supporting solid or semi-solid form with a restraining polymer (14). Entrapped in and dispersed randomly throughout each agar bead (10) is a water-soluble, preferably polar, restraining polymer (14), preferably a quaternized cationic polymer, such as polyquaternium (24) or steardimonium hydroxyethylcellulose. Various active agents (16) may be bound to restraining polymer (14), for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.
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A DETERGENT COMPOSITION

(WO1998049259) 05.11.1998 C11D 3/00 UNILEVER PLC
A detergent composition having excellent colour care properties when used to launder coloured fabrics. The composition comprises: a) a dye transfer inhibiting polymer comprising one or more monomeric units containing at least one = N-C(=O) with the proviso that the dye transfer inhibiting agent does not comprise an -oxide group, and b) a water soluble sunscreen.
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PERSONAL CARE COMPOSITIONS CONTAINING LINEAR TOUGHENED SILICONE GRAFTED POLYMERS

(WO1998048776) 05.11.1998 A61K 8/89 THE PROCTER &GAMBLE COMPANY
A personal care composition comprising: (a) a silicone grafted adhesive polymer, said polymer being characterized by an organic polymeric backbone wherein said backbone comprises: (i) at least one monomer wherein when said monomer is polymerized as a homopolymer having a Tg of from about -120 C to about 25 C and (ii) at least one monomer wherein when said monomer is polymerized as a homopolymer having a Tg of from above about 25 C to about 250 C wherein said silicone grafted adhesive polymer has silicone macromers grafted to said backbone and wherein the number average molecular weight of said silicone macromers is greater than about 1000; and (b) a personal care carrier.
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COMPOSITIONS FOR COSMETIC APPLICATIONS

(WO1998048768) 05.11.1998 A61K 8/02 MEDLOGIC GLOBAL CORPORATION
A cosmetic composition is described having a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.
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METHOD AND COMPOSITION FOR TARGETED DELIVERY OF COMPOUNDS

(WO1998046210) 22.10.1998 A61K 8/04 KATOOT, Mohammad, W.
The present invention relates to a novel composition and method for making novel microspheres for delivering compounds to desired locations $i(in vivo) and $i(in vitro). This invention also provides microspheres which exhibit special properties for loading with desired concentrations of compounds, obtaining desired rates and amounts of compounds released, and for targeting release of compounds at specific sites. This invention also provides novel microspheres which are made using microwaves. The microspheres of the present invention can be used to deliver compounds for cosmetic, therapeutic, and agricultural applications.
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DELIVERY SYSTEMS FOR ACTIVE INGREDIENTS INCLUDING SUNSCREEN ACTIVES AND METHODS OF MAKING SAME

(WO1998046200) 22.10.1998 A61K 8/04 SHAMROCK TECHNOLOGIES, INC.
The present invention provides methods of making delivery systems for active ingredients including hydrogenated jojoba and sunscreen actives. The recrystallization process of the present invention produces small particle size alloys from molten mixtures and recrystallized small particle size dispersions from high temperature solvent solutions. The invention further provides delivery systems for active ingredients such as sunscreen actives.
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SUNSCREEN COMPOSITION AND METHOD OF PRODUCING SAME

(WO1998038965) 11.09.1998 A61K 8/29 WILKINS, Brian, Joseph
This invention relates to a composition suitable for application to the skin of a human for use as a sunscreen product, the composition having been formed by combining a metal carboxylate, a medium, and an ultra-violet radiation absorbing agent, the metal carboxylate and the medium together forming a viscous gel or fluid containing the absorbing agent. The invention further includes a method of producing a sunscreen product comprising the steps of combining the ingredients above and heating the mixture to a sufficient temperature and for a sufficient period of time to dissolve the metal carboxylate, and suitably cooling the mixture to produce a gel sunscreen product.
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SUNSCREENS FOR PROTECTION FROM SUN RADIATION

(WO1998031333) 23.07.1998 A61K 8/11 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
The present invention relates to sunscreen-doped sol-gel materials useful for protecting body tissues, such as skin, nails and hair and other surfaces from sunlight radiation. The sol-gel matrices are transparent to the UV radiation in the range above 250 nm and the doped sunscreen agents are either chemical or physical sunscreens capable of absorbing the UV radiation in the range above 250 nm. Any sunscreen molecule, moiety or particle may be used in the present invention. The sol-gel matrices may be particles in any shape, 0.01 - 100 microns in diameter, or they may be thin films, thin coatings or in the form of a monolith. The present invention also relates to a method for the preparation of sunscreen-doped sol-gel materials comprising c...
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FABRIC TREATMENT COMPOSITIONS

(WO1998030663) 16.07.1998 C11D 3/26 UNILEVER PLC
A detergent composition which reduces the photofading of fabric and protects underlying skin from UV-rays. The detergent composition comprises an anionic surfactant and a cationic UV absorber having general formula (I), in which R represents a hydrogen atom or an alkyl group containing 1 to 12 carbon atoms and Y represents a halogen atom, a methyl group or a hydrogen atom and X represents any suitable counter-ion.
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COMPOSITION FOR ENHANCING SKIN OR HAIR

(WO1998030198) 16.07.1998 A61K 8/49 CONREX PHARMACEUTICAL CORPORATION
A composition and its use for enhancing the qualities of skin or hair, the composition comprising: (A) a skin-treating compound or a hair-treating compound; (B) an enhancer having structure (I) wherein: X and Y are oxygen, sulfur, or an imino group of the structure =N-R, with the proviso that when Y is the imino group, X is an imino group and when Y is sulfur, X is sulfur or an imino group; A is a group having the structure (a) wherein X and Y are defined; m and n are integers having a value of from 1 to 20 and the sum of m + n is not greater than 25; p is an integer having a value of 0 or 1; q is an integer having a value of 0 or 1; r is an integer having a value of 0 or 1; and R is hydrogen or an alkyl group having from 1 to 6 carbon atom...
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CATIONIC FILM-FORMING POLYMER COMPOSITIONS CONTAINING SAME, AND USES THEREOF, INCLUDING TOPICAL DELIVERY SYSTEM AND METHOD OF DELIVERING AGENTS TO THE SKIN AND HAIR

(WO1998028355) 02.07.1998 A61K 8/87 MACROCHEM CORPORATION
A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I) R-(CO)m?Y?1-(CH2?CHR?1O)n?- [CONH-Z-NHCO(OCH2?CHR?2)n'?-Y?2-(CH2?CHR?2O)n''?]p? -CONH-Z-NHCO-(OCH2?CHR?1)n?-Y?1(CO)m?R where R represents (i) an alkyl, alkenyl or alkaryl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group or polybutylene oxide group; R?1 and R?2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; when m = 0, Y?1 represents O, NR?3 or N?+R?3R?4X?- and when m = 1 Y?1 represents O; Y?2 represents O, NR?3, N?+R?3R?4X?-, (R?3NCH2?CH2?)t?, or [(R?3R?4N?+..
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PARTICLES HAVING SURFACE PROPERTIES AND METHODS OF MAKING THEM

(WO1998028339) 02.07.1998 A01N 25/10 CIBA SPECIALTY CHEMICALS WATER TREATMENTS LIMITED
Polymer particles comprising a hydrophobic organic matrix and located at the exterior free cationic groups and a further polymer which comprises free hydroxy groups. The particles are produced by an aqueous suspension polymerisation process wherein the continuous aqueous phase contains a polymerisation stabiliser and a dissolved vinyl addition cationic monomer. The polymerisation stabiliser can be any suitable polymer that comprises free hydroxy groups. The process results in polymers of average particle size in the range 50 to 150 microns and reduced levels of undesired polymer emulsion or undersized particles. The particles are particularly useful for absorbing water insoluble active ingredients, such as insecticides, insect repellents, f...
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SUNSCREEN WITH DISAPPEARING COLOR INDICATOR

(WO1998023255) 04.06.1998 A61K 8/06 SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.
A colored, sunscreen emulsion is disclosed which employs a water-soluble dye or a blend of water-soluble dyes whose color substantially disappears when the sunscreen emulsion dries after it is spread on the skin and/or is rubbed out. The coloration in the sunscreen enables the user to more effectively protect against sunburn by allowing more complete and uniform coverage of the sunscreen on the skin. The sunscreen emulsion comprises: a) at least one water-soluble dye that imparts a color other than white to the sunscreen emulsion, such that when the sunscreen emulsion dries after it is spread on the skin and/or is rubbed out, the color substantially disappears; b) at least one sunscreen active in an amount effective to protect against the a...
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NON-CHEMICAL SUNSCREEN COMPOSITION

(WO1998019651) 14.05.1998 A61K 8/29 E-L MANAGEMENT CORPORATION
The present invention relates to non-chemical sunscreen composition comprising as its active components, in synergistically effective amounts, a plant extract containing at least about 50 % by weight of proanthocyanidins, $g(g)-oryzanol, ferulic acid and/or an ester thereof, titanium dioxide and optionally, $i(Scutellaria) extract.
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ESTER-TERMINATED POLYAMIDE GELS

(WO1998017243) 30.04.1998 A61K 8/88 UNION CAMP CORPORATION
An ester-terminated dimer acid-based polyamide may be blended with a solvent to form a gel. The solvent may be flammable, and a wick may be added to the resulting gel so as to form a candle. Depending on the composition, the candle may be formed into a free standing pillar, or may be better suited to being placed in a container. The solvent may be mineral oil. A solid coating may be placed around the candle, for advantages including to enhance the clarity and/or mechanical stability of the gelled body, and to eliminate the tendency of a gel to have an oily feel and to accept noticeable fingerprints. The ester-terminated dimer acid-based polyamide may also be combined with an active ingredient, such as a fragrance, colorant, insect-repellant...
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STABLE PHOTOPROTECTIVE COMPOSITIONS

(WO1998013016) 02.04.1998 A61K 8/27 THE PROCTER &GAMBLE COMPANY
The present invention relates to compositions which are useful for providing protection to the skin of humans from the harmful effects of ultraviolet radiation. In particular the present invention relates to compositions having improved chemical, physical, and photostability. These compositions comprise from about 0.1 % to about 10 % of a dibenzoylmethane sunscreen compound, from about 0.1 % to about 20 % of a surface-treated zinc oxide, and a carrier suitable for application to the skin.
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FORMULATIONS FOR TOPICAL USE

(WO1998010793) 19.03.1998 A61K 47/22 PANIN, Giorgio
A formulation for topical use comprising a lipophilic phase which includes vitamin E or a pharmaceutically acceptable ester thereof, preferably vitamin E acetate, amongst its components, generally in an amount of from 20 to 100 %, preferably from 51 to 100 %, based on the weight of the lipophilic phase; the latter phase may also contain animal, vegetable or synthetic fats and oils or mineral oils. The ointment may be in the form of an oil, ointment, cream, hydrophobic gel, or paste. The vitamin E acetate is used as an excipient or as a component of excipients for pharmaceutical formulations for topical use.
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SOLID COSMETIC COMPOSITION WITH HEXANEDIOL-BEHENYL BEESWAX

(WO1998009612) 12.03.1998 A61K 8/26 COLGATE-PALMOLIVE COMPANY
Disclosed is a solid (e.g., cream, such as semi-solid or soft solid) cosmetic composition containing an active cosmetic material (e.g., a deodorant active, an antiperspirant active, a sunscreen, an insect repellent and/or an anti-fungal agent), volatile (e.g., cyclomethicone) and linear chain (e.g., dimethicone and/or phenyl trimethicone) silicone materials, and at least one gelling agent. The at least one gelling agent includes hexanediol-behenyl beeswax, and is included in the composition in an amount sufficient to provide the solid composition. By incorporating the hexanediol-behenyl beeswax as a gelling agent, conventional gelling agents such as fatty alcohols and hydrogenated castor oil need not be incorporated in the composition. When...
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SKIN TANNING COMPOSITIONS AND METHOD

(WO1998007416) 26.02.1998 A61Q 19/04 E-L MANAGEMENT CORP.
Disclosed are cosmetic compositions for providing an artificial tan to skin which comprise dihydroxyacetone and an azole in a cosmetically or pharmaceutically acceptable carrier. Also disclosed is a method for providing an artificial tan to skin which comprises applying dihydroxyacetone and an azole to the skin.
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AN OIL-IN-WATER EMULSION FOR USE ON HUMAN SKIN FOR CLEANSING, PRESERVING OR IMPROVING THE CONDITION OF THE SKIN

(WO1998005294) 12.02.1998 A61K 8/06 PLUM KEMI PRODUKTION A/S
An oil-in-water emulsion, especially for use on mammalian skin, in particular on human skin, or hair in order to cleanse the skin or hair, remove dirt, etc., and/or to preserve or improve the condition of the skin, and/or to prevent or treat various skin conditions such as, e.g., dry skin, irritated skin or otherwise traumatized skin. Upon application on a skin surface and following rinsing or flushing the skin surface with a liquid, the oil-in-water emulsion separates into at least two distinct phases and leaves a protective layer on the skin comprising at least a part of the oily phase. The oil-in-water emulsion also has useful properties with respect to protection of the skin against sun light and with respect to combatting attack from p...
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TOPICAL PRODUCT FORMULATIONS CONTAINING STRONTIUM FOR REDUCING SKIN IRRITATION

(WO1997048371) 24.12.1997 A61K 8/19 COSMEDERM TECHNOLOGIES HAHN, Gary, Scott THUESON, David, Orel QUICK, Timothy, W.
A topical formulation for reducing skin irritation in animals is described which comprises about .5 to about 10 % by weight of the total formulation of an aqueous-soluble strontium cation in a suitable topical formulation vehicle. The figure shows experimental data where strontium nitrate is selected as the anti-irritant salt component of the subject formulation.
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METHOD AND COMPOSITION FOR SKIN LIGHTENING

(WO1997047280) 18.12.1997 A61K 8/06 UNILEVER PLC UNILEVER N.V.
A method and composition is provided for treating skin to achieve lightening by employing an active of structure (I), wherein R is selected from the group consisting of hydrogen, hydroxy and C1-C30 alkyl or aryl groups radicals; and R1 is selected from the group consisting of hydrogen and C1-C30 alkyl or aryl radicals.
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PHOTOPROTECTIVE LIPOPHILIC ANTIOXIDANT COMPOUNDS

(WO1997047279) 18.12.1997 A61K 8/34 JOHNSON &JOHNSON CONSUMER PRODUCTS, INC.
The present invention relates to a method of protecting skin from the oxidative effects of ultraviolet A radiation including UVA-induced lipid peroxidation. The method comprises topically applying to the skin an effective amount of a photoprotective composition that contains a lipophilic antioxidant that does not have appreciable absorbance near wavelengths of 320-380 nm.
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COMPOSITIONS AND USES THEREOF

(WO1997046219) 11.12.1997 A61K 8/27 CRODA INTERNATIONAL PLC COUPLAND, Keith PACKER, Claire, Elizabeth
A sunscreen composition comprising a stearidonic acid, or a physiologically derivative thereof, in combination with a UV blocking and/or UV absorbing material. Also stearidonic acid may be used to treat inflammation caused by exposure to UV radiation, by exposure to sunlight or by burns.
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DETERGENT COMPOSITION

(WO1997044422) 27.11.1997 C11D 1/14 UNILEVER PLC UNILEVER N.V.
A detergent composition comprising a liquid photofading inhibitor having a log P value of at least 1.9 or a solid photofading inhibitor dissolved in a liquid, the liquid having a log P of at least 1.9 or mixtures thereof. The composition has a nonionic surfactant/cationic material based deposition system to deposit the photofading inhibitor.
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COSMETIC CREAM COMPOSITION CONTAINING SILICONE GEL MATERIAL

(WO1997044010) 27.11.1997 A61K 8/58 COLGATE-PALMOLIVE COMPANY
Disclosed is a solid cosmetic composition (e.g., a cream composition) containing an active cosmetic material (e.g., a deodorant active, an antiperspirant active, a sunscreen, an insect repellent and/or an anti-fungal agent) and a silicone gel material. The silicone gel material includes (a) a volatile silicone material and (b) an organopolysiloxane material as a gelling agent, able to form a gel after being mixed with the volatile silicone material. The organopolysiloxane material can be a reaction product of a vinyl-terminated siloxane polymer and a hydride cross-linking agent. The composition can be formed by mixing the active cosmetic material and silicone gel material at ambient temperature. The compositions do not need particulate or c...
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IMPROVED WATER RESISTANT SUNSCREEN AND INSECT REPELLENT COMPOSITION

(WO1997042933) 20.11.1997 A61K 8/35 IGUANA, L.L.C.
An improved sunscreen protection and insect repellent combination composition having an SPF factor of about 2 to about 50 and further having an unexpected, unusually long efficacy period when used in rainy conditions or prolonged periods of high humidity, such as in a tropical or sub-tropical rain forest, or the like, and after the wearer has been underwater. The composition forms a stable emulsion lotion that is easy to store. No special precautions are required by the person who applies the lotion. The composition includes a sunscreen agent, an insect repellent, an emulsifying agent, and a film former, all in an aqueous solvent. The composition forms a thin film on the skin, but it is non-greasy to the touch. The lotion is easily removed ...
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USE OF TEMPOL IN THE PREVENTION OF PHOTOAGING

(WO1997041826) 13.11.1997 A61K 8/49 THOMAS JEFFERSON UNIVERSITY BERNSTEIN, Eric
A method of preventing photoaging and other types of sun damage by topically applying a composition containing Tempol is provided. Pharmaceutical compositions comprising Tempol for the prevention of photoaging and other types of sun damage are also provided.
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COMPOSITION, BARRIER FILM, AND METHOD FOR PREVENTING CONTACT DERMATITIS

(WO1997040813) 06.11.1997 A61K 31/715 HYDROMER, INC. DALLA RIVA TOMA, Joan KARL, Curtis, L.
The present invention relates to a composition, and a method for preventing or reducing contact dermatitis. The composition contains a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material. The present invention is further a dermatologically-compatible barrier film for preventing and reducing contact dermatitis which contains a polysaccharide; a low molecular weight, synergistic saccharide; and optionally one or more additives. The dermatologically-compatible barrier film is formed of a composition containing a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material. The composition is a skin care product in a form of a lotion, a ...
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METHOD OF PROTECTING AGAINST SUNBURN

(WO1997039723) 30.10.1997 A61Q 17/04 REPPER, George, R. REPPER, Helen, Z.
A method and kit for applying a chemical composition, e.g., for protecting a body against sunburn, utilize application of a chemical composition, e.g., a sunscreen, to external portions of a body, with the composition being capable of fluorescing at a first visible wavelength under illumination from light of a second wavelength. The body is illuminated with light of the second wavelength so as to cause the composition to fluoresce. The body is viewed while the body is under illumination of the second wavelength, so as to identify any non-fluorescing, missed external portions of the body to which the composition was not previously applied. The composition is further applied to any missed body portions.
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AMINO- AND HYDROXYSUBSTITUTED TRIPHENYL-S-TRIAZINES AS STABILIZERS

(WO1997036880) 09.10.1997 C07D 251/24 CIBA SPECIALTY CHEMICALS HOLDING INC. REINEHR, Dieter METZGER, Georges MICHAELIS, Peter LUTHER, Helmut
The present invention provides compounds having the formula (1) or (1A) in which R is hydrogen, hydroxy, halogen, C1-C20-alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy or C7-C13aralkyl; R1 and R2, independently, are hydrogen, C1-C20alkyl, C4-C12cycloalkyl, C7-C13aralkyl, -C(=O)-R4 (in which R4 is C1-C20alkyl, C2-C20alkyl interrupted by 1 to 6 oxygen atoms, hetero-substituted C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, C6-C12aryl, C6-C12aryloxy or C7-C13aralkyl), or -C(=O)-NH-R1 in which R1 has its previous significance; and R3 is hydrogen, halogen, hydroxy, C1-C20alkyl, C4-C12cycloalkyl, ...
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DERMAL PENETRATION ENHANCERS AND DRUG DELIVERY SYSTEMS INVOLVING SAME

(WO1997029735) 21.08.1997 A61K 8/04 MONASH UNIVERSITY REED, Barry, Leonard MORGAN, Timothy, Matthias FINNIN, Barrie, Charles
A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, ...
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PHOTOPROTECTIVE COMPOSITIONS

(WO1997028785) 14.08.1997 A61K 8/27 THE PROCTER &GAMBLE COMPANY
The present invention relates to leave on, skin care compositions, comprising: (a) from about 0.1 % to about 30 % of a sunscreen active, (b) from about 0.5 % to about 20 % of a hydrophobic, structuring agent, (c) from about 0.2 % to about 10 % of a hydrophilic surfactant, (d) from about 0.1 % to about 5 % of a thickening agent, and (e) water. These compositions are useful for providing protection to human skin from the harmful effects of ultraviolet radiation.
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SUBSTITUTED o-AMINOCARBONYLBENZOIC ACID SALTS AND THEIR USE AS SUNSCREENS

(WO1997025971) 24.07.1997 A61K 8/42 STEPAN COMPANY GEORGE, Liliana SOTTERY, John
Disclosed are methods and compositions for increasing the sun protection factor of oil and water sunscreen emulsions comprising adding a phthalic acid derivative to an oil and water sunscreen emulsion in an amount effective to increase the sun protection factor of the emulsion, the phthalic acid derivative having general formula (I) where R represents an organic substituent, X represents a cation, and m is an integer satisfying the valency of X.
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COMPOSITIONS CONTAINING VITAMIN D DERIVATIVES FOR TREATMENT OF PHOTODAMAGED SKIN

(WO1997025050) 17.07.1997 A61K 8/34 F. HOFFMANN-LA ROCHE AG
Compositions containing compounds of formula (I) wherein R1 is hydrogen, hydroxy or fluorine, R2 is hydrogen or halogen and A is (a), (b) or (c), provided that when A is -CH2-CH2-, R2 is hydrogen; for topical agents to combat disorders of the skin produced by photodamage such as wrinkling, elastosis and premature aging.
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SUNSCREENING COMPOSITIONS COMPRISING NATURAL PRODUCTS OF A MARINE HYDROID, AND DERIVATIVES THEREOF

(WO1997019671) 05.06.1997 A61K 8/46 LINDQUIST, Niels, L.
The invention relates to novel UVB/UVA-absorbing chromophores that are present in the natural products of a marine hydroid, and derivatives thereof, useful as sunscreening agents. Furthermore, the present invention relates to methods for protecting skin from the damaging effects of solar ultraviolet radiation. This method comprises topically applying to the skin an effective coating of a sunscreen composition of the present invention. Additional embodiments of the invention use these natural UV-absorbing compounds, or derivatives thereof, as additives as a means of providing UV-protective plastics, paints, and waxes.
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UV ABSORBING COMPOSITIONS

(WO1997017406) 15.05.1997 A61K 8/04 M &J BOS CONSULTANTS PTY. LTD. ELLIS, David, Graham BOS, Michael, Ary
A process for producing a liquid dispersion of an inorganic oxide selected from zinc oxide, titanium dioxide and iron oxide, and having a particle size in the range of 0.02 to 30 'mu'm, the process including comminuting the oxide in the presence of the liquid, the liquid being constituted by or including a component having available hydrogen and/or oxygen ions. The liquid is selected from one of an alcohol, ester, hydrogenated ester or polymer containing hydroxyl or hydrogen group(s). The stable dispersion which does not aggregate or agglomerate is suitable for use in topical preparations such as skin care or therapeutic products, cosmetics or hair care products.
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COSMETIC AND COSMECEUTICAL COMPOSITIONS

(WO1997016155) 09.05.1997 A61K 8/67 RIKLIS, Emanuel
Cosmetic and cosmeceutical compositions which enhance repair of damage caused to human DNA caused by excessive exposure to sunlight or to other radiation causing such damage. The active ingredients are a synergistic combination of nor-dihydroguiaretic acid (NDGA) and niacinamide. Optional components are propyl gallate or other antioxidants. Composition may further contain sun-screen additives.
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SUNSCREEN COMPOSITIONS

(WO1997003643) 06.02.1997 A61K 8/42 CIBA SC HOLDING AG LUTHER, Helmut STEHLEIN, Albert MINKLEI, Marina
The present invention provides a method of producing a composition, suitable for use in pharmaceutical or cosmetic compositions, comprising a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of 0.1 to 30 % by weight of an alkyl polyglucoside having the formula CnH2n+1O(C6H10O5)xH, in which n is an integer ranging from 8 to 16 and x is the mean polymerisation level of the glucoside moiety (C6H10O5) and ranges from 1.4 to 1.6, or an ester thereof.
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SUNSCREEN COMPOSITIONS

(WO1997003642) 06.02.1997 A61K 8/49 CIBA SC HOLDING AG STEHLIN, Albert KREYER, Gilbert LUTHER, Helmut
The present invention provides a solution, suitable for use in pharmaceutical or cosmetic compositions, comprising a) 1-40 % by weight of a compound having formula (1), in which R1, R2 and R3, independently, are H, OH, C1-C18alkoxy, NH2, NH-R4 or N(R4)2 in which R4 is C1-C18alkyl, OR4 in which R4 has its previous significance, phenyl, phenoxy or anilino, or pyrrolo, in which the respective phenyl or pyrrolo moieties are optionally substituted by one, two or three substituents selected from OH, carboxy, C1-C18alkyl or -alkoxy, C1-C18carboxyalkyl, C5-C8cycloalkyl, a methylidenecamphor group, a group -(CH=CH)nC(=O)-OR4 in which n is 0 or 1 and R4 has its previous significance or a group (a) or the corresponding alkali metal, ammonium, mono-, d...
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LOW VOC, SUNSCREEN SPRAY COMPOSITION CONTAINING A HYDROPHOBIC, FILM-FORMING POLYMER

(WO1997003559) 06.02.1997 A01N 25/04 ISP INVESTMENTS INC.
Stable, water-based formulations containing high levels of water insoluble UV protectants/insecticides are provided herein as sprayable microemulsions containing a film-forming polymer, e.g. Agrimer VEMA ES 425 [poly(methyl vinyl ether-maleic acid monobutyl ester)]. The polymers are solubilized either by partial neutralization with a base, or by emulsification with appropriate emulsifiers. These formulations produce single phase, micro- or mini-emulsions (particle size < 1 micron) on dilution with water. The formulations are useful as UV protectants in veterinary use, for protection of UV-labile insecticides, and for "pour on" applications.
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LIPOPHILIC AND AMPHIPHILIC FILM-FORMING POLYMER COMPOSITIONS, AND USE THEREOF IN TOPICAL AGENTS DELIVERY SYSTEM AND METHOD OF DELIVERING AGENTS TO THE SKIN

(WO1997001327) 16.01.1997 A61K 8/87 MACROCHEM CORPORATION SAMOUR, Carlos, M. KRAUSER, Scott, F.
A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I): R(CO)mO-(CH2CHR1O)n-[OCNH-Z-NHCO2(CH2CHR2O)n']p-OCNH-Z-NHCO2-(CH2CHR1O)n-(CO)mR, wherein R represents (i) an alkyl, alkenyl or alkaryl hydrocarbyl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group (PPO); R1 and R2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; n and n', are each, independently, a positive number; and p is > 0, preferably p is 0 or 1, provide a skin substantive, occlusive moisture barrier covering for skin or hair. The compositions have a moisturizing effect by reducing transepidermal water loss. The lipophilic or ...
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CHEMICAL COMPOUNDS AND METHODS OF PRODUCTION THEREOF

(WO1997000851) 09.01.1997 A61K 8/37 ZYLEPSIS LIMITED CHEETHAM, Peter, Samuel, James BANISTER, Nigel, Eric
A compound having formula (B) and salts or adducts thereof wherein R1 and R2 are the same or different and represent H, OH, NH2, CO2H or OR6; R4 and R5 are the same or different and represent H, OH, NH2 or OR6; R6 is a straight or branched chain C1-C16 alkyl, alkylene or alkylyne or a substituted or unsubstituted homocyclic or heterocyclic aromatic group; R3 is a substituted or unsubstituted homocyclic or heterocyclic aromatic ring which is in conjugation with a group R7; R7 is a substituted or unsubstituted homocyclic or heterocyclic aromatic ring, an alkene, or an alkane substituted with a functional group capable of entering into conjugation with R3. Such a compound has the ability to absorb ultraviolet radiation in both the uvA and uvB ...
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A RINSE-OFF COSMETIC CLEANSING COMPOSITION

(WO1996041610) 27.12.1996 A61K 8/06 UNILEVER PLC UNILEVER N.V.
A rinse-off cleansing composition including at least one surfactant-soluble cosmetic benefit agent and at least one surfactant is provided. The composition comprises a first emulsion having a continuous phase comprising the surfactant and an internal phase comprising a second emulsion. The second emulsion has a continuous phase comprising a carrier in which the cosmetic benefit agent is substantially insoluble and an internal phase comprising the cosmetic benefit agent and an emulsifier therefor. The carrier is surfactant-insoluble. By protecting the cosmetic benefit agent enhanced deposition thereof is achieved during use of the composition.
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TITANIUM DIOXIDE HYDROGEL AND SUNSCREEN COMPOSITION CONTAINING IT

(WO1996037560) 28.11.1996 C09C 1/00 THE PROCTER &GAMBLE COMPANY
A TiO2 hydrogel and method of preparation therefor is disclosed. TiO2 particles ranging in size from at least about 50 nm to about 150 nm wherein the particle is about 20 % to about 90 % anatase are disclosed. Topical sunscreen compositions, which comprise 1 % to about 15 % anatase/amorphous TiO2 are also disclosed. This composition provides UVA and UVB protection without concomitant dulling or discoloring the skin. The composition also has enhanced stability, is invisible, is easy to apply in an even manner and resists discoloration (or "color-changing") or decomposition on the shelf or on the skin.
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IMMUNOSTIMULATING-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996037230) 28.11.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic immunostimulating-wound healing compositions. The compositions comprise a therapeutically effective amount of an immunostimulating agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic immunostimulating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic immunostimulating-wound healing compositions and the pharmaceutical products in which the compositions may be used.
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ANTIHISTAMINE-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996037229) 28.11.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic antihistamine-wound healing compositions. The compositions comprise a therapeutically effective amount of one or more antihistamine agents and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antihistamine-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antihistamine-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
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ANTIBACTERIAL-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996037228) 28.11.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic antibacterial-wound healing compositions. The compositions comprise a therapeutically effective amount of an antibacterial agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antibacterial-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antibacterial-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
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DERMATOLOGICAL-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996037227) 28.11.1996 A61K 31/20 WARNER-LAMBERT COMPANY
The present invention pertains to therapeutic dermatological-wound healing compositions useful to minimize and treat diaper dermatitis. The compositions comprise a therapeutically effective amount of a buffering agent to maintain the pH of the dermatitis in a range from about 5 to about 8, an anti-inflammatory agent, and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and c) a mixture of saturated and unsaturated fatty acids. The therapeutic dermatological-wound healing compositions may be utilized in a wide variety of topical pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic dermatological-wound healing composition...
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A COSMETIC PRODUCT TO PREVENT AND CORRECT SKIN DAMAGE

(WO1996037179) 28.11.1996 A61K 8/02 UNILEVER PLC UNILEVER N.V.
A cosmetic product is provided to prevent and correct skin damage. The product includes a first composition for daytime use incorporating a sunscreen to prevent UV radiation damage, a second composition for nighttime use containing a C2-C30 'alpha'-hydroxycarboxylic acid or salt thereof to correct UV-induced skin damage, and respective first and second containers for separately storing each of the first and second compositions. The containers are releasably lockable together by a coupling mechanism such as a threaded screw arrangement. Preferably, the first and second containers are stackable one above the other in the releasably locked arrangement.
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LIPOSOMOGENIC UV ABSORBERS

(WO1996029302) 26.09.1996 A61K 8/49 CIBA-GEIGY AG LUTHER, Helmut HGLIN, Dietmar HERZOG, Bernd
There are described liposomogenic UV absorbers, comprising a hydrophilic head group (=Z), a spacer (=W), a UV chromophore (Q) having an absorption in the range from 285 to 400 nm and at least one hydrophobic tail group (=A) of the formula (1), in which A1 and A2, independently of one another, are a hydrophobic radical, Q is a UV chromophore, W is an organic radical, Z1 and Z2, independently of one another, are a hydrophilic radical, n1 and n2, independently of one another, are a number from 0 to 4, n1=n2=0 not being additionally included, p is 1 or 2, q is a number from 0 to 3, r1 is 1 or 2, r2 is 0 or 1, and s1 is a number from 1 to 3. The liposomogenic UV absorbers according to the invention are preferably used as sunscreen agents in cosm...
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BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER

(WO1996028431) 19.09.1996 C07D 251/10 CIBA-GEIGY AG FLETCHER, Ian, John KASCHIG, Jrgen METZGER, Georges REINEHR, Dieter HAYOZ, Pascal
A description is given of biphenyl-substituted triazine compounds of formula (1). The biphenyl-substituted triazine compounds, which are notable for high thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fibre materials, and as sunscreens for the human skin.
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COSMETIC MAKEUP COMPOSITION

(WO1996023484) 08.08.1996 A61K 8/06 MAYBELLINE INTERMEDIATE CO. COHEN, Kenneth SUSS, Harold
A water-in-oil emulsified cosmetic makeup composition includes sunscreen agent, free radical scavenger, moisturizing agent/re-hydrating agent, skin firming agent and cosmetically acceptable pigment. The composition when applied to the skin smoothes, moisturizes, firms and protects the skin from the effects of the environment and improves complexion.
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ANHYDROUS COSMETIC COMPOSITIONS WITH DERMATOLOGICALLY ACTIVE AGENTS

(WO1996021422) 18.07.1996 A61K 07/48 MARY KAY INC.
Novel cosmetic compositions containing topical delivery systems for polar dermatologically active agents are disclosed. Active agents, for example, skin revitalizing alpha hydroxy acids are absorbed or adsorbed on to preferably porous carrier particles with the assistance of a viscous polar solvent such as glycerin, if necessary, and dispersed in an anhydrous cosmetic base along with a film-forming system. Such compositions can be formulated into a variety of different cosmetic products, for example eye shadows, eye treatment primers and lip treatments, each providing significant immediate cosmetic benefits and longer term dermatologic activity.
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SKIN REVITALIZING MAKEUP COMPOSITION

(WO1996019180) 27.06.1996 A61K 8/06 MAYBELLINE INTERMEDIATE CO.
An emulsified cosmetic makeup for revitalizing, smoothing, moisturizing and tightening the skin is disclosed. The composition comprises cosmetically effective amounts of a film forming agent containing plant polysaccharides and hydrolyzed casein, at least one sunscreen agent, at least one natural exfoliating agent, at least one moisturizer/re-hydrating agent encapsulated in liposome vessicles, at least one preservative, at least one antioxidant agent, at least one cosmetically acceptable pigment and at least one emulsifier.
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SUNSCREEN-WOUND HEALING COMPOSITION

(WO1996017624) 13.06.1996 A61K 45/06 WARNER-LAMBERT COMPANY
The present invention pertains to therapeutic sunscreen-wound healing compositions useful to minimize and treat sunburn damage. The compositions comprise a therapeutically effective amount of (1) a sunscreen agent; (2) an anti-inflammatory; and, (3) a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic sunscreen-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic sunscreen-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
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COSMETIC COMPOSITION

(WO1996016634) 06.06.1996 A61K 8/19 UNILEVER PLC UNILEVER N.V.
A cosmetic composition comprising a hydroxy material selected from: a) layered double hydroxides of formula (I): [M(1-a)Na(OH)2]y+ Xx-y/x. zH2O where M is selected from divalent metal ions and lithium; N is a trivalent metal ion; X is an anion of charge x-; y+ is the net charge on the mixed metal hydroxide cation; and when M is a divalent metal ion a is a number from 0.17 to 0.5 and y = a; when M is lithium a is a number from 0.67 to 0.75 and y = (2a-1): and z is a number from 0 to 10; and b) a hydroxy salt of formula (II): [M' (OH)(2-a')]a'+ (Xx-)(a'/x). zH2O where M' is at least one divalent metal ion; a' is a number in the range 0.05 to 1; X is an anion of charge x-; and z is a number from 0 to 10; and c) mixtures thereof and wherein at ...
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ACNE TREATING-WOUND HEALING COMPOSITIONS CONTAINING A PYRUVATE, AN ANTIOXIDANT AND A MIXTURE OF FATTY ACIDS

(WO1996014868) 23.05.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic acne treating-wound healing compositions useful for the topical treatment of acne vulgaris. The compositions comprise a therapeutically effective amount of tretinoin and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic acne treating-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic acne treating-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used. This invention also relates to methods...
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LOTION WHICH IS TEMPORARILY COLORED UPON APPLICATION

(WO1996014826) 23.05.1996 A61K 8/49 SEEUV
A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches...
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SPRAYABLE COMPOSITIONS CONTAINING DISPERSED POWDERS AND METHODS FOR USING THE SAME

(WO1996014051) 17.05.1996 A61K 8/04 ESTEE LAUDER, INC.
Stable, sprayable compositions suitable for topical application to human skin or hair are provided, along with a method for their preparation. The compositions comprise water-in-oil emulsions and a variety of substantially insoluble dispersed powder. The compositions are useful for applying color to human skin or hair, for protecting human skin from ultraviolet radiation, and for treating human skin or hair with a dermatologically active agent. The compositions have unique suspending power, stability and dispersibility for water-in-oil emulsions.
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RAZOR CARTRIDGES COMPRISING WOUND HEALING COMPOSITIONS

(WO1996010474) 11.04.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic wound healing compositions useful for preventing and reducing injury to mammalian cells affixed to razor cartridges to form therapeutic razor cartridges with wound healing compositions. In one embodiment of this invention the therapeutic wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. This invention also pertains to methods for making and using the razor cartridges comprising therapeutic wound healing compositions.
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DERIVATIZED POLYESTER COMPOUNDS AND USES THEREOF

(WO1996006878) 07.03.1996 A61K 8/85 INOLEX INVESTMENT CORPORATION
Polyester resins made from aliphatic dicarboxylic acid and dihydric compounds are modified to provide derivatized polyesters having functional groups. The functional groups include anionic, cationic, quaternary ammonium, zwitterionic, polyamine acid chain, nonionic, essential oils, botanical derivatives or silicone-based polymers. These derivatized polyesters have use as formulation aids and conditioning agents in hair and skin personal care products.
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BIOADHESIVE-WOUND HEALING COMPOSITION

(WO1996006640) 07.03.1996 A61K 31/355 WARNER-LAMBERT COMPANY
The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may b...
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TOPICALLY-EFFECTIVE COMPOSITIONS

(WO1996006594) 07.03.1996 A61K 07/34 HELENE CURTIS, INC.
Roll-on or gel topically-effective compositions comprising a topically-active compound, a silicon-free surfactant or silicon-free surfactant blend having an HLB value of about 0.1 to about 10, an organic phase comprising a volatile silicone compound or a volatile hydrocarbon compound, and water.
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A DRYER-ADDED FABRIC TREATMENT ARTICLE OF MANUFACTURE CONTAINING ANTIOXIDANT AND SUNSCREEN COMPOUNDS FOR SUN-FADE PROTECTION OF FABRICS

(WO1996003492) 08.02.1996 C11D 1/62 THE PROCTER &GAMBLE COMPANY
The present invention relates to a dryer-added fabric treatment article of manufacturing to reduce the fading of fabrics from sunlight comprising: I) a composition comprising: a) from about 5 % to about 75 %, by weight of the composition, of a sun-fade protection active selected from the group consisting of: (i) a non-fabric staining, light stable, antioxidant compound preferably containing at least one C8-C22 hydrocarbon fatty organic moiety; (ii) a non-fabric staining, light stable, sunscreen compound; and (iii) mixtures thereof; b) from about 10 % to about 95 % by weight of the composition of a fabric conditioning compound; and II) a substrate, on which said composition is attached, which provides for release of an effective amount of sa...
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RINSE ADDED FABRIC SOFTENER COMPOSITIONS CONTAINING SUNSCREENS FOR SUN-FADE PROTECTION FOR FABRICS

(WO1996003486) 08.02.1996 C11D 1/52 THE PROCTER &GAMBLE COMPANY
The present invention relates to fabric care compositions to reduce the fading of fabrics from sunlight, comprising: (A) from about 1 % to about 25 % by weight of the composition, of a non-fabric staining, light stable sunscreen compound preferably containing at least one C8-C22 hydrocarbon fatty organic moiety; (B) from 3 % to about 50 % by weight of a fabric softening compound; and (C) from about 25 % to about 95 % by weight of a carrier material; wherein the sunscreen compound absorbs light at a wavelength of from about 290 nm to about 450 nm; wherein the sunscreen compound is a solid material having a melting point of from about 25 C to about 90 C or a viscous liquid at a temperature of less than about 40 C.
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RINSE ADDED FABRIC SOFTENER COMPOSITIONS CONTAINING ANTIOXIDANTS FOR SUN-FADE PROTECTION FOR FABRICS

(WO1996003481) 08.02.1996 C11D 1/62 THE PROCTER &GAMBLE COMPANY
The present invention relates to fabric care compositions to reduce the fading of fabrics from sunlight, comprising: (A) from about 1 % to about 25 % by weight of the composition of a non-fabric staining, light stable antioxidant compound, preferably containing at least one C8-C22 hydrocarbon fatty organic moiety; (B) from 3 % to about 50 % by weight of the composition of a fabric softening compound; (C) from about 25 % to about 95 % by weight of the composition of a carrier material; and (D) optionally, from about 0 % to about 20 % by weight of the composition of a non-fabric staining, light stable sunscreen compound, preferably containing at least one C8-C22 hydrocarbon fatty organic moiety; wherein the antioxidant compound is a solid mat...
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ANTIFUNGAL-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996003149) 08.02.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic antifungal-wound healing compositions. The compositions comprise a therapeutically effective amount of an antifungal agent and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antifungal-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antifungal-wound healing compositions and the pharmaceutical products in which the compositions may be used.
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ANTI-INFLAMMATORY WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996000584) 11.01.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic anti-inflammatory wound healing compositions. The compositions comprise a therapeutically effective amount of one or more anti-inflammatory agents and a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic anti-inflammatory wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic anti-inflammatory wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.
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ANTIKERATOLYTIC-WOUND HEALING COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

(WO1996000572) 11.01.1996 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic antikeratolytic-wound healing compositions. The compositions comprise a therapeutically effective amount of an antikeratolytic agent and a wound healing composition. In one embodiment the wound healing composition comprises: (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic antikeratolytic-wound healing compositions may be utilized in a wide variety of topical and ingestible pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic antikeratolytic-wound healing compositions and the pharmaceutical products in which the compositions may be used.
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COMPOSITE UV SUNBLOCK COMPOSITIONS

(WO1995028912) 02.11.1995 A61K 8/04 SUNSMART, INC. SUBMICRO ENCAPSULATION TECHNOLOGIES, INC.
The invention encompasses topical sunblock formulae for shielding skin from ultraviolet radiation, and a composite sunblocking component thereof. The sunblocking component of the formula includes an effective amount of a plurality of particles having diameters in the range of about 0.01 - 100 microns, each particle including a matrix and a UV-attenuating compound incorporated into the matrix. The composite sunblocking component may include a particle that is colored or transparent, depending upon the matrix, UV-attenuating compound and the particle size. The sunblocking component is dispersible in water and thus in water-based dermatological carriers. The formula includes these particles dispersed within a dermatologically acceptable liquid...
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ANTIVIRAL WOUND HEALING COMPOSITION CONTAINING A PYRUVATE, AN ANTIOXIDANT, A MIXTURE OF FATTY ACIDS AND AN ANTIVIRAL COMPOUND

(WO1995027501) 19.10.1995 A61K 31/355 WARNER-LAMBERT COMPANY
This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One(I)). This invention also pertains to therapeutic antiviral-wound healing compositions for reducing viral titers and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (...
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ARTIFICIAL TANNING COMPOSITIONS HAVING IMPROVED COLOR DEVELOPMENT

(WO1995026179) 05.10.1995 A61Q 19/04 THE PROCTER &GAMBLE COMPANY
The present invention relates to artificial tanning compositions that provide improved color development and good chemical and physical stability. These compositions comprise dihydroxyacetone, certain amino acids or their pharmaceutically acceptable salts, and a topical carrier, wherein said compositions have a pH value of less than about 4. In other embodiments these compositions comprise dihydroxyacetone, certain amino acids or their pharmaceutically acceptable salts, and a stabilizing salt selected from the group consisting of metabisulfite salts, sulfite salts, hydrogen sulfite salts, and mixtures thereof, and a topical carrier.
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ARTIFICAL TANNING COMPOSITIONS HAVING IMPROVED STABILITY

(WO1995026178) 05.10.1995 A61Q 19/04 THE PROCTER &GAMBLE COMPANY
The present invention relates to artificial tanning compositions having improved stability. These compositions comprise dihydroxyacetone, a salt selected from the group consisting of metabisulfite salts, sulfite salts, hydrogen sulfite salts, and mixtures thereof. These compositions are useful for imparting an artificial tan to human skin. In further embodiments, these compositions also comprise a sunscreen agent and are also useful for providing protection from the harmful effects of ultraviolet radiation.
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METHODS OF USING CYCLIC POLYANIONIC POLYOL DERIVATIVES FOR REGULATING SKIN WRINKLES

(WO1995023588) 08.09.1995 A61K 8/39 THE PROCTER &GAMBLE COMPANY
The subject invention relates to methods of regulating skin wrinkles and/or atrophy in mammalian skin comprising topically applying to the skin of a mammal in need of treatment a composition comprising a safe and effective amount of a cyclic polyanionic polyol derivative having structure (I) wherein n is an integer from 1 to 3; and each X is, independently, selected from the group consisting of OSO3-, OPO3=, SO3-, PO3=, CO2-, and OH; with at least 3 X's being other than OH.
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SUNSCREEN COMPOSITIONS

(WO1995022959) 31.08.1995 A61K 8/42 CIBA-GEIGY AG DMLER, Walter FANKHAUSER, Peter LUTHER, Helmut
The present invention provides a micronised, insoluble organic UV absorber which is especially suitable for use in pharmaceutical or cosmetic applications, with the exclusion of o-hydroxyphenyl-s-triazines having formula (I) in which Ra, Rb and Rc, independently, are hydrogen, halogen, C1-C18alkyl or C1-C18alkoxy, and Rd and Re, independently, are hydrogen or C1-C18alkoxy, with the provisos that one of Rd and Re is always C1-C18alkoxy, and that, if Rb, Rc, Rd and Re are each C1-C18alkoxy, then Ra is halogen, C1-C18alkyl or C1-C18alkoxy; and a sunscreen composition comprising the micronised, insoluble organic UV absorber together with a cosmetically compatible carrier. The UV absorber is of the oxalamide, triazine, triazol, vinyl-group conta...
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IMPROVED WATER RESISTANT SUNSCREEN PROTECTION AND INSECT REPELLENT COMPOUND

(WO1995019161) 20.07.1995 A61K 07/42 STEWART, Ernest, G.
An improved waterproof sunscreen protection and insect repellent combination compound having an SPF factor of 15 and further having an unexpected unusually long efficacy period when used in rainy conditions and prolonged periods of high humidity as in tropical and sub-tropical rain forests or the like, and in underwater conditions as in swimming. The compound forms a lotion that is easy to store. The lotion can be applied to the skin of a person with little or no training. No special precautions are required by the person when applying the lotion. The compound has a sweet taste when applied to the lips and is pleasantly scented. The compound forms a thin waterproof film on the skin, but is non-greasy to the touch. The lotion is easily remov...
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GAS MICROSPHERES FOR TOPICAL AND SUBCUTANEOUS APPLICATION

(WO1995015118) 08.06.1995 A61K 8/14 UNGER, Evan, C. MATSUNAGA, Terry YELLOWHAIR, David
Gas and gaseous precursor filled microspheres (1), and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics (2).
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COMPOSITIONS CONTAINING ZINC LINOLEATE FOR THE TREATMENT OF SKIN DISORDERS

(WO1995013806) 26.05.1995 A61K 31/315 KAPPA PHARMACEUTICALS LIMITED BRYCE-SMITH, Derek
There is disclosed a composition for the treatment of skin disorders comprising zinc linoleate and free linoleic acid in a pharmaceutically acceptable carrier.
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SYNTHETIC MELANIN

(WO1995009629) 13.04.1995 A61Q 19/04 YALE UNIVERSITY
A melanin that is soluble in an aqueous solution at a pH between 5 and 9 at a temperature of 0 to 100 C. Advantageously, the melanin is capable of being filtered through at least a 0.45 micron size filter, and has a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and an appropriate enzyme, or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone or with 5,6-dihydroxyindole, or with 3-amino-tyrosine. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial materi...
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METHOD AND APPARATUS FOR CUSTOMISING COSMETIC PRODUCTS

(WO1995005891) 02.03.1995 B01F 13/10 UNILEVER PLC UNILEVER N.V.
A machine is provided for customising a cosmetic product at point of sale to a customer. The dispensing machine of the invention includes a mechanism for receiving operating instructions about a customer's optimal formula; a series of dispensers each containing a different cosmetic composition; a mechanism for activating dosing to a common dosing chamber of certain of the cosmetic compositions and at certain concentrations as determined by the operating instructions; and a mechanism for delivering the dosed formula into a container to the customer as a cosmetic product. Other advantageous features include a temperature regulation system, dual pumps of different capacity for obtaining highly accurate dosing, a bar code labelling system, and ...
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QUATERNARY SALTS OF PARA-DIALKYLAMINO BENZAMIDE DERIVATIVES

(WO1995005797) 02.03.1995 C07C 237/34 ISP VAN DYK INC.
This invention relates to non-hydrolyzable, non-irritating, hair, skin and textile substantive quaternary ammonium salts of a para-dialkylamino benzamide having formula (I) wherein R' and R'' are each selected from the group of C1 to C2 alkyl; n is an integer having a value of from 2 to 6; R is an alkyl radical having from 1 to 30 carbon atoms; R1 and R2 are each selected from the group of C1 to C4 alkyl, hydrogen and, alternatively, R1 and R2, together with the attached cationic nitrogen atom can form a 5 to 6-membered heterocyclic ring selected from the group (a, b, c, d, e, f and g) and X is an anion. These benzamide derivatives are active sunscreening agents which are usefully employed at a concentration of from about 0.5 to about 10 wt...
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SUNSCREEN AGENTS

(WO1995005150) 23.02.1995 A61K 31/30 UNILEVER PLC UNILEVER N.V.
Hydroxy salts of the formula [M(OH)(2-a)]a+ Xb-a/b . zH2O, where M is zinc, copper or a mixture of the two and X denotes anions at least some of which display ultraviolet absorption over at least a portion of the wavelength range from 290 to 400 nanometres, their use as sunscreen agents and sunscreen compositions comprising them together with a cosmetically acceptable vehicle.
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NOVEL MATERIALS AND METHODS UTILIZING A TEMPORARY VISUAL INDICATOR

(WO1994026233) 24.11.1994 A61K 6/00 FUERST, Ronnie, S. MELKER, Richard BATICH, Christopher, D.
This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.
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COMPOSITIONS FOR IMPARTING AN ARTIFICIAL TAN AND PROTECTING THE SKIN FROM UV RADIATION

(WO1994023693) 27.10.1994 A61Q 19/04 THE PROCTER &GAMBLE COMPANY
The present invention relates to emulsion compositions which are useful for imparting both an artificial tan to human skin and for providing protection to the skin from the harmful effects of UV radiation. These compositions have good stability at acidic pH values, are highly substantive to the skin, and provide a natural looking tan.
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SUNBLOCKING, EMULSIFYING PROTEINACEOUS PARTICULATE LOTION AND MANUFACTURE

(WO1994021222) 29.09.1994 A61K 8/64 NURTURE, INC.
A method for preparing a natural proteinaceous sun protectant formulation from a lipophilic phase, an aqueous phase, and a substantially chemically intact proteinaceous particulate material that acts as a multi-purpose emulsifying agent, resulting in a sun protectant having the property of forming a dry film upon evaporation of the aqueous phase after application of the emulsion to a surface, wherein the proteinaceous particulate material also acts to screen the surface from the sun. Also provided is a sun protectant lotion including the above lipophilic phase, aqueous phase, and emulsifying agent.
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DIMERIC ACIDS IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS

(WO1994020067) 15.09.1994 A61K 31/20 THE BOOTS COMPANY PLC BARTON, Stephen, Peter
An emulsion comprises a dicarboxylic acid of formula (I) wherein R1 and R3 are each C6 to C10 alkyl and R2 to R4 are each C6 to C10 alkylene (or a cosmetically acceptable salt thereof) and an effective amount of an emulsifying agent chosen such that the emulsion may be shear-thickened in use. The compound of formula (I) is also useful in sunscreens as an anti-free-radical agent.
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SUNSCREEN COMPOSITION

(WO1994020066) 15.09.1994 A61K 8/97 UNILEVER PLC UNILEVER N.V.
A cosmetic compositon is provided which includes green tea and a sunscreen compound which is effective to at least partially block ultraviolet radiation from harming human skin, and a pharmaceutically acceptable carrier.
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LIGHT STABLE COLOR COMPOSITIONS

(WO1994018932) 01.09.1994 C09B 63/00 WHITTAKER, CLARK &DANIELS, INC. LAMBRIDIS, George GOODWIN, Nathanial
A composition comprising colorant-containing particles having a coating comprising propylene glycol and a carrier component selected from the group consisting of carriers suitable for food, drug and cosmetic preparations and mixtures thereof.
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NEW SUNBLOCKING POLYMERS AND THEIR FORMULATION

(WO1994014410) 07.07.1994 A61K 8/33 BIOPHYSICA, INC.
Novel polymeric compositions and their intermediates are provided, providing for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with another hydrophilic monomer to provide sunscreen formulations for invisibility, and enhanced protection, without deleterious effects in the dermis.
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SELF-TANNING COSMETIC COMPOSITIONS AND METHODS OF USING THE SAME

(WO1994012146) 09.06.1994 A61Q 19/04 ESTEE LAUDER, INC.
The present invention relates to novel cosmetic preparations for artificially tanning the skin. These novel cosmetics are applied to the skin in a sprayable mist application. These cosmetics are oil and alcohol free and are quick drying. Further, these cosmetic preparations provide an even, deeper and long lasting artificial tan.
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PHOTOSTABLE SUNSCREEN COMPOSITIONS

(WO1994004131) 03.03.1994 A61K 8/19 THE PROCTER &GAMBLE COMPANY
The present invention relates to sunscreen compositions having improved photostability, especially in the UVA region, along with providing broad coverage in both the UVA and UVB regions. These compositions are achieved by combining a UVA-absorbing dibenzoylmethane sunscreen with a UVB-absorbing benzylidene camphor sunscreen. In highly preferred embodiments, these compositions also contain from about 0.1 % to about 25 % of an inorganic physical sunblock. These compositions are useful for protecting the skin from the harmful effects of ultraviolet radiation and for moisturizing the skin.
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PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER

(WO1994002176) 03.02.1994 A61K 8/35 THE PROCTER &GAMBLE COMPANY
The present invention relates to pharmaceutical compositions for topical application comprising a safe and effective amount of a pharmaceutical active, from about 0.1 % to about 10.0 % of a high molecular weight cationic polymer, from about 0.05 % to about 5 % of a high HLB non-ionic surfactant, and from about 0.1 % to about 25 % of an alkoxylated ether. In further embodiments, these compositions also comprise from about 0.01 % to about 5 % of a low HLB non-toxic surfactant.
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SYNTHETIC MELANIN

(WO1993021252) 28.10.1993 A23L 1/275 YALE UNIVERSITY PAWELEK, John, M. OSBER, Michael, P. ORLOW, Seth, J.
A melanin that is soluble in an aqueous solution at a pH between 5 and 9 at a temperature of 0 to 100 C. Advantageously, the melanin is capable of being filtered through at least a 0.45 micron size filter, and has molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and an appropriate enzyme, or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone or with 5,6-dihydroxyindole, or with 3-amino-tyrosine. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial material...
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COMPOSITIONS FOR REGULATING SKIN WRINKLES AND/OR SKIN ATROPHY

(WO1993010755) 10.06.1993 A61K 8/02 RICHARDSON-VICKS, INC.
The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
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ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS

(WO1993007903) 29.04.1993 A61K 47/32 RICHARDSON-VICKS, INC.
The invention relates to pharmaceutical compositions for topical application comprising a safe and effective amount of a pharmaceutical active, and from about 0.1 % to about 10.0 % of a high molecular weight cationic polymer. These compositions provide enhanceed penetration of the pharmaceutical active.
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ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS

(WO1993007902) 29.04.1993 A61K 8/35 RICHARDSON-VICKS, INC.
The invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05 % to about 5 % of a non-ionic polyacrylamide having a molecular weight of from about 1,000,000 to about 30,000,000.
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LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVES

(WO1993007856) 29.04.1993 A61K 8/81 RICHARDSON-VICKS, INC.
A skin care composition in the form of a low pH aqueous gel. The compositions provide improved skinfeel and residue characteristics together with excellent moisturizing, emolliency, rub-in and absorption characteristics. The gel comprises 0.05 % to 20 % of a non-ionic polyacrylamide having a molecular weight from 1,000,000 to 30,000,000, a humectant, an emollient and possibly pharmaceutically or cosmetically active compound (drugs, anti-acne, tanning or sunscreen agent).
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SUNSCREEN COMPOSITION

(WO1993002117) 04.02.1993 A61K 8/81 ISP INVESTMENTS, INC.
What is provided herein is a sunscreen composition consisting essentially of a crosslinked, neutralized terpolymer of maleic anhydride, a C1-C5 alkyl vinyl ether and a C12-C14 alpha-olefin monomer as a thickener; water; an ultraviolet sunscreening agent; and an emulsifier. In the prefered form of the invention, the monomers are present in a molar ratio of about 1:0.90-0.99:0.01-0.10, respectively, and are crosslinked with about 2-8 wt.% of a crosslinking agent based on the total weight of the monomers. Suitably, the crosslinked terpolymer is neutralized to increase water solubility.
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COMPOSITION AND METHOD OF ENHANCING SUN TANNING

(WO1992020321) 26.11.1992 A61K 8/19 STIEFEL LABORATORIES, INC. WOOD, John, Martin SCHALLREUTER, Karin, Uta
Sun tanning, especially of fair skin, is enhanced by topical application of a pseudocatalase prior to exposure to sunlight or UVB light. The preferred pseudocatalases are transition metal co-ordination complexes, especially manganese (II) bicarbonate.
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ARTIFICIAL TANNING COMPOSITIONS CONTAINING POSITIVELY CHARGED PAUCILAMELLAR VESICLES

(WO1992019214) 12.11.1992 A61K 8/14 RICHARDSON-VICKS INC.
The present invention relates to oil-in-water emulsion compositions useful for imparting an artificial tan to human skin. These emulsions contain paucilamellar lipid vesicles, i.e. vesicles comprising several concentric lipid bilayers, encapsulating an aqueous dihydroxyacetone solution. The vesicles comprise a polyoxyalkylene alkyl ether, a sterol, a quaternary ammonium compound, and optionally, a non-surface active oil. In further embodiments, these emulsion compositions contain one or more sunscreens, and are also useful for protecting human skin from the harmful effects of sunlight and other sources of ultraviolet radiation. The present invention also relates to methods for preparing these compositions, methods for providing an artificia...
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STABILIZED EMULSION COMPOSITIONS FOR IMPARTING AN ARTIFICIAL TAN TO HUMAN SKIN

(WO1992017159) 15.10.1992 A61Q 19/04 RICHARDSON-VICKS INC.
The present invention relates to stabilized emulsion compositions for imparting an artificial tan to human skin. These emulsions contain dihydroxyacetone, at least one alkyl phosphate, and at least one carboxylic acid copolymer in which the ratio of alkyl phosphate to carboxylic acid copolymer is from about 5:1 to about 1:5. In further embodiments, these emulsion compositions contain one or more sunscreens, and are also useful for protecting human skin from the harmful effects of sunlight and other sources of ultraviolet radiation. The present invention also relates to methods for preparing these compositions, methods for providing an artificial tan to human skin, and methods for protecting human skin from the harmful effects of ultraviolet...
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NOVEL ENCAPSULATED MATERIALS

(WO1992016195) 01.10.1992 A23L 1/22 THE PROCTER &GAMBLE COMPANY
This invention relates to polymeric liquid crystals prepared from a polysaccharide and a solvent, preferably water, which are used to deliver nutrients, perfumes, flavors, drugs and other ingredients in foods, cosmetics, household soaps, health care products e.g. bar or liquid soaps, toothpaste, shampoos, creams, and lotions and other preparations. The encapsulated active vehicle comprises: (a) from about 0.001 % to about 60 % of an active; and (b) from about 40 % to about 99.999 % of a stable polymeric liquid crystal consisting essentially of: (1) from about 10 % to about 90 % of a solvent; and (2) from about 10 % to about 90 % of a polysaccaride having a molecular weight of from about 500 to about 1,000,000.
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SOLUBLE MELANIN

(WO1992016189) 01.10.1992 A23L 1/275 YALE UNIVERSITY
A melanin that is soluble in an aqueous solution at a pH of at lest 5 to 9 at a temperature of 0 to 100 C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is a...
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PROTECTIVE COMPOSITIONS

(WO1992016103) 01.10.1992 A01N 25/24 REDLINE PRODUCTS, INC.
Active ingredient containing liquid formulations wherein the active ingredient is made water and oil resistant after application thereof to a substrate by the addition to the formulation of a fluorinated acrylic copolymer. The substrate can be either an animate or inanimate object. Active ingredients include repellents, attractants, pesticides, growth regulators, sunscreen agents, or medicines. The liquid formulations can be aqueous or organic solvent based or a mixture thereof.
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THERAPEUTIC AND COSMETIC COMPOSITIONS FOR TREATMENT OF SKIN

(WO1992015276) 17.09.1992 A61K 8/98 McGINNIS, Michael
An active ingredient for a therapeutic or cosmetic comosition is obtained from live gastropoda (e.g., snails) which are physically stimulated (e.g., by centrifuging) to cause secretion of a fluid which is then centrifuged and filtered. Preferably the gastropoda are fasted prior to the physical stimulation. The therapeutic or cosmetic compositions contain about 0.1-30 % of the active ingredient which is a mixture of amino acids and atoxic substances, an effective amount of an excipient preferred for use with biologically active ingredients, and other conventional ingredients provided they do not affect the stability and/or the activity. The therapeutic composition, in the form of a topical cream, can be used to treat various types of burns, ...
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COMPOSITION

(WO1992013520) 20.08.1992 A01N 37/28 IMPERIAL CHEMICAL INDUSTRIES PLC AUSTIN, Peter, William SINGER, Michael
A personal care formulation which contains, as an anti-microbial agent, a compound containing the structure -C(S)-N(OR)- or a salt or complex thereof, for example a 2:1 complex or salt of 3-hydroxy-4- methylthiazol-2(3H)thione and zinc. The personal care formulation may be an oil-in water or water-in-oil emulsion such as hand lotions and emollient creams, or may be shampoos and the like.The anti-microbial agent has good activity against micro-organisms together with a low toxicity.
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METHODS AND COMPOSITIONS FOR AMELIORATION OF SKIN WRINKLES

(WO1992007587) 14.05.1992 A61K 8/65 NARHEX LIMITED
There are disclosed compositions for the amelioration of wrinkles of the skin, an methods for their use. The compositions comprise, as active substance, elastin, at least some of which has a molecular weight of less than 10,000. The compositions may further comprise an agent for reducing corneocyte cohesion of the lower levels of the hyperkeratotic stratum of the skin, such agent being typically an alpha-hydroxy acid. The methods of use of the compositions of the invention may comprise topical application or subcutaneous injection.
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METHODS AND PREPARATIONS OF STABLE, DEODORIZED OILS AND PHARMACEUTICAL COMPOSITIONS THEREOF

(WO1991016914) 14.11.1991 A61K 8/92 BOCKOW, Barry, I.
Some otherwise desirable oil compositions derived from natural sources are characterized by an unpleasant odor. Fractions or combinations of such oils may also be so characterized. Stable, deodorized oils may be prepared by adding an amount of a deodorizing agent effective to substantially reduce the odor of the derived oil composition, fraction or combination thereof to that oil composition, fraction or combination. The pharmaceutical topical compositions of the present invention contain these stable, deodorized oil compositions and exhibit enhanced penetration properties and achieve enhanced patient response. THe improved pharmaceutical compositions of the present invention may be used to manage pain and/or to treat the underlying ailment...
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INSECT REPELLENT LOTIONS AND SPRAYS

(WO1991015118) 17.10.1991 A01N 49/00 PRIMAVERA LABORATORIES, INC.
An insect repellent is provided and includes turpeniol, citronella, and one or both of rhodenol extract and geraniol as actives provided in a conveying medium. The actives are used in small percentages, e.g. as little as .01 %, preferably at between .05 % and .08 %, and preferably less than 1 %, yet are synergistically efficacious, particularly against ticks carrying Lyme disease. The conveying medium can be a cosmetic moisturizer lotion, with or without a sun screen. For a spray, the conveying medium can be water or alcohol based. An attractive fragrance is preferably provided as approximately .4 % of the insect repellent. The lotion or spray is safely applied in liberal quantities to humans and animals without unpleasant side effects such...
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NON-AQUEOUS EMULSION OF SILICONE OIL AND STEARINE

(WO1991010771) 25.07.1991 D06M 13/02 STULTS, Jerry, F. GREENE, George, H. PHILLIPS, James, C.
A non-aqueous emulsion comprises a stearine, a silicone, and, optionally, a diluent such as a glyceride, and a silicone emulsifier. The stearine is present in an amount sufficient to provide a non-aqueous emulsion when the components are melted together and mixed until the emulsion is set. The silicone oil is preferably a dimethyl silicone which can be optionally endblocked while the preferred stearine comprises hydrogenated rapeseed stearine or hydrogenated castor stearine. The non-aqueous emulsion can be employed as a lubricant for natural or synthetic fibers. In addition, the non-aqueous emulsion can be employed within a cream or ointment composition with at least one active ingredient.
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COMPOSITIONS AND METHODS FOR REDUCING THE RISK OF SUNLIGHT AND ULTRAVIOLET INDUCED SKIN CANCER

(WO1991007166) 30.05.1991 A61K 38/55 WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION, INC RYAN, Clarence, A.
Compositions and methods for reducing the risk of skin cancer. The novel compositions include at least one effective protease inhibitor. Preferred protease inhibitors include protease enzyme inhibitors of the serine class of proteases; protease enzyme inhibitors of the cysteine class of proteases; protease enzyme inhibitors of the aspartyl class of proteases; protease enzyme inhibitors of the metallo class of proteases; protease enzyme inhibitors of the carboxy-peptidase class of proteases; protease enzyme inhibitors of the trypsin class of proteases; protease enzyme inhibitors of the chymotrypsin class of proteases; protease enzyme inhibitors of the pancreatic proteases; protease enzyme inhibitors of the elastase class of proteases; protea...
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ULTRAVIOLET LIGHT-ABSORBING COMPOUNDS AND SUNSCREEN FORMULATIONS AND POLYMERIC MATERIALS CONTAINING SUCH COMPOUNDS OR RESIDUES THEREOF

(WO1991002715) 07.03.1991 C07C 255/41 EASTMAN KODAK COMPANY
Disclosed are certain poly-methine compounds having formula (I), wherein each R1 is independently selected from cyano; carboxy; alkenyloxycarbonyl; an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; an unsubstituted or substituted, carbocyclic or heterocyclic aryl radical; an unsubstituted or substituted alkanoyl, cycloalkanoyl or aroyl radical; an unsubstituted or substituted carbamoyl radical; or an unsubstituted or substituted alkylsulfonyl, cycloalkylsulfonyl or arylsulfonyl radical; each R2 is independently selected from cyano or an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl radical; each A is independently selected from an unsubstituted or substitute...
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UV-ABSORBING COMPOUNDS AND COMPOSITIONS

(WO1990009995) 07.09.1990 C07D 211/70 ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITED
The invention provides UV-absorbing compounds of formula (I), processes for preparing compounds of formula (I) and compositions, including sunscreens, containing compounds of formula (I), wherein A and B are alkyl, haloalkyl or together form a carbocyclic ring; R?1 is alkyl, haloalkyl, substituted alkyl where the substituent is selected from hydroxy, amino, alkoxy, alkanoyl, alkoxycarbonyl, phenyl and the radical of formula (I(a)), wherein A, B, R?2 and R?3 are as herein defined; alkenyl, cycloalkyl; phenyl; the groups phenyl and benzyl; said groups being substituted in the benzene ring by alkyl, alkenyl and alkoxy; and wherein R?1 and R?2 may form a carbocyclic ring; R?2 is hydrogen or alkyl; R?3 is alkyl, substituted alkyl, ...
World  Patents Published  in 2007
   
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WORLD PATENTS IN SUN CARE PUBLISHED FROM 1990 TO 2006
This list includes patent documents published by the World Intellectual Property Organization (WIPO). The list was retrieved by using a refined search strategy in the claims section of all
patent applications. Salient search terms included formulations such as sunscreen creams, lotions, sprays, UVA and UVB filters, free radicals scavenging, sun protection, photostable
compositions, water resistant sunscreen lotions, bronzers, tanners, sunless tanners, titanium dioxide, zinc oxide as well as efficacy and clinical testing of SPF and UVA by in-vivo and in-vitro
methods, etc.