World Patents in Skin Care Actives Published in 2010

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PCT - WORLD PATENTS IN SKIN CARE ACTIVES PUBLISHED IN 2010


Title: METHOD OF EXTRACTION FROM WITHANIA SOMNIFERA AND ONE OR MORE FRACTIONS CONTAINING PHARMACOLOGICALLY ACTIVE INGREDIENTS OBTAINED THEREFROM

Publication No: WO2010/150275
Pub. Date - Int. Class - Applicant: - 29.12.2010 - None - BIO-VED PHARMACEUTICALS, PVT. LTD.
A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro- alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containin...


Title: SECRETORY GRANULES AND GRANULOGENIC FACTORS AS A TARGET FOR CANCER TREATMENT

Publication No: WO2010/147274
Pub. Date - Int. Class - Applicant: - 23.12.2010 - G01N 33/50 - INHA-INDUSTRY PARTNERSHIP INSTITUTE
The present invention relates to a method for screening a cancer therapeutic agent, comprising the steps of: (a) contacting a test substance of interest with a cell containing a granulogenic factor-encoding nucleotide sequence; and (b) analyzing expression of the granulogenic factor or production of secretory granules, wherein the test substance is determined as the cancer therapeutic agent where it inhibits the expression of the granulogenic factor or the production of secretory granules. In the present invention, the expression of the granulogenic factor contributes to induction of secretory granule formation in non-secretory cells, and inhibition of the granulogenic factor expression leads to inhibition of secretory granule formation in ...


Title: COMBINATION OF AT LEAST TWO ACTIVE INGREDIENTS FOR COSMETIC USE

Publication No: WO2010/134206
Pub. Date - Int. Class - Applicant: - 25.11.2010 - A61K 8/67 - L'OREAL
The present invention relates to a combination of at least two, preferably all, of (a) an extract of amalaki, (b) an extract of pomegranate, and (c) at least one carotenoid. The above combination can function as an anti-oxidizing agent, a cell energizing agent, and a skin microrelief protecting agent. The above combination is preferably contained in a cosmetic composition which is intended to be applied onto the skin.


Title: PHARMACEUTICAL SYSTEM FOR TRANS-MEMBRANE DELIVERY

Publication No: WO2010/132605
Pub. Date - Int. Class - Applicant: - 18.11.2010 - A61K 9/28 - PROTEIN DELIVERY SOLUTIONS, LLC
Non-invasive drug delivery systems useful for the absorption of therapeutically active agents through the epithelial membrane are described. The non-invasive drug delivery system delivers a therapeutic active agent with an ionizable, or ionized, metal, transition metal or metal-containing vehicle. The non-invasive drug delivery system may also have a pH adjustable vehicle which facilitates the absorption of the therapeutic agents by altering the pH of the non-invasive drug delivery system at the site of administration. Also disclosed is a method for the pH "sweeping" of the administered therapeutic active agent to provide a consistent and reproducible absorption of the active agent. Certain formulations utilize low doses of active...


Title: COMPOSITIONS SUITABLE FOR THE TOPICAL TREATMENT OF FUNGAL INFECTIONS OF THE SKIN AND NAILS

Publication No: WO2010/130028
Pub. Date - Int. Class - Applicant: - 18.11.2010 - A61K 31/185 - BIOCEPTA CORPORATION
Pharmaceutical compositions suitable for the topical treatment of fungal infections of the skin and nails, such as tinea pedia and tinea cruris, among others. The active ingredients of the compositions are low molecular weight organic acids and theirs salts in synergistic combination of two or more acids The antifungal activity of the active ingredients is further enhanced through the use of non- volatile hygroscopic solvents.


Title: FORMULATION FOR ORAL ADMINISTRATION OF APOPTOSIS PROMOTER

Publication No: WO2010/127198
Pub. Date - Int. Class - Applicant: - 04.11.2010 - A61K 9/00 - ABBOTT LABORATORIES
An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatm...


Title: A PHARMACEUTICAL, DERMATOLOGICAL, NUTRITIONAL OR COSMETIC COMPOSITION FOR COMBATING THE IMMUNOSUPPRESSIVE ACTION OF AGGRESSIVE AGENTS ON THE SKIN

Publication No: WO2010/125541
Pub. Date - Int. Class - Applicant: - 04.11.2010 - A23L 1/30 - GIULIANI S.P.A.
The object of the invention is a mixture of catechin and quercetin in a molar ratio varying between 3:1 and 6:1, respectively, for the treatment of the immunosuppression induced in the skin by aggressive agents such as airborne pollutants, dehydrating agents, ultraviolet radiation, and thermal and osmotic shocks, and a pharmaceutical, dermatological, nutritional or cosmetic composition containing said mixture as an active ingredient.


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER AND MOMETASONE, AND A PROCESS TO MAKE IT

Publication No: WO2010/122494
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/00 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises: a) a biopolymer in the form of Chitosan, b) active Pharmaceutical Ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate & Mometasone furoate, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. A process to make the medicinal cream containing Fusidic acid whic...


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, A CORTICOSTEROID, AND AN ANTIFUNGAL AGENT, AND A PROCESS TO MAKE IT

Publication No: WO2010/122493
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/575 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises: a) a biopolymer in the form of Chitosan, b) active pharmaceutical ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate, Hydrocortisone acetate & Miconazole nitrate, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The invention also discloses a pro...


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER AND A CORTICOSTEROID, AND A PROCESS TO MAKE IT

Publication No: WO2010/122492
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises: a) a biopolymer in the form of Chitosan, b) Active Pharmaceutical Ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate & Hydrocortisone acetate, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The invention also discloses a process to make medicinal cream...


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, A CORTICOSTEROID, AND AN ANTIFUNGAL AGENT, AND A PROCESS TO MAKE IT

Publication No: WO2010/122491
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/575 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises: a) a biopolymer in the form of Chitosan, b) active Pharmaceutical Ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate Hydrocortisone acetate & clotrimazole, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The invention also discloses a process to ...


Title: A MEDICINAL ANTIBACTERIAL AND STEROIDS CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT

Publication No: WO2010/122478
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), namely Framycetin Sulphate & Dexamethasone Acetate, used in treating bacterial skin infections and skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, a corticosteroid in the form of Dexamethasone Acetate, and an antibacterial in the form of Framycetin Sulphate are incorporated in ...


Title: A MEDICINAL ANTIFUNGAL, ANTIBACTERIAL AND STEROID CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT

Publication No: WO2010/122477
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal/bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), namely Clotrimazole, Framycetin Sulphate & Dexamethasone Acetate, used in treating fungal & bacterial skin infections and skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, a corticosteroid Dexamethasone Acetate, an antibacterial in the form of Framycetin Sulphate and a...


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, MICONAZOLE AND MOMETASONE, AND A PROCESS TO MAKE IT

Publication No: WO2010/122476
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises a) a biopolymer in the form of Chitosan, b) active Pharmaceutical Ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate, Mometasone furoate & Miconazole nitrate, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan,...


Title: A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, CLOTRIMAZOLE AND MOMETASONE, AND A PROCESS TO MAKE IT

Publication No: WO2010/122475
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises a) a biopolymer in the form of Chitosan, b) active Pharmaceutical Ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate, Mometasone furoate & clotrimazole, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, Momet...


Title: A MEDICINAL ANTIFUNGAL AND STEROID CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT

Publication No: WO2010/122474
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/00 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), namely Miconazole Nitrate & Mometasone Furoate, used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, a corticosteroid in the form of Mometasone Furoate, and an antifungal agent in the form of Miconazole Nitrate, are incorporated in cream b...


Title: A MEDICINAL ANTIFUNGAL AND STEROID CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT

Publication No: WO2010/122473
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), namely Clotrimazole & Mometasone Furoate, used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, a corticosteroid in the form of Mometasone Furoate, and an antifungal agent in the form of Clotrimazole, are incorporated in cream base for use i...


Title: A MEDICINAL CREAM CONTAINING MICONAZOLE NITRATE, HYDROCORTISONE ACETATE, AND A BIOPOLYMER, AND A PROCESS TO MAKE IT

Publication No: WO2010/122453
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 31/4164 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), miconazole and hydrocortisone acetate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservat...


Title: A MEDICINAL ANTIFUNGAL AND STEROID CREAM INCORPORATING A BIOPOLYMER AND A PROCESS TO MAKE IT

Publication No: WO2010/122452
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 9/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antifungal active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), clotrimazole and hydrocortisone acetate used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, b...


Title: A TUBERCULOSIS TB VACCINE TO PREVENT REACTIVATION

Publication No: WO2010/121618
Pub. Date - Int. Class - Applicant: - 28.10.2010 - A61K 39/04 - STATENS SERUM INSTITUT
The present invention discloses a vaccine or immunogenic composition that can be administred to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms (Mycobacterium tuberculosis., M.bovis, M.africanum), The invention is base on a number of M. tuberculosis derived proteins and protein fragments which are constitutively expressed in different stages of the infection. The invention is directed to the use of these polypeptides, immunologically active fragments thereof and the genes encoding them for immunological compositions such as vaccines.


Title: A MEDICINAL CREAM MADE USING MICONAZOLE NITRATE, FLUTICASONE PROPIONATE, AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119387
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 9/00 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), fluticasone proprionate & miconazole nitrate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acid...


Title: A MEDICINAL CREAM MADE USING CLOTRIMAZOLE, FLUTICASONE PROPIONATE, AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119386
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 47/36 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) a combination of active pharmaceutical ingredients (APIs), namely Clotrimazole & Fluticasone Propionate used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, a corticosteroid in the form of Fluticasone Propionate, and an antifungal agent in the form of Clotrimazole, are incorporated in cream base f...


Title: A MEDICINAL CREAM MADE USING MOMETASONE FUROATE, AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119384
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 9/107 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of mometasone furoate, used in treating skin inflammation c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and a corticostero...


Title: A MEDICINAL CREAM MADE USING FRAMYCETIN SULPHATE CREAM AND CHITOSAN, AND A PROCESS TO MAKE IT

Publication No: WO2010/119383
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 9/06 - VANANGAMUDI , Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of framycetin sulphate used in treating bacterial skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingre...


Title: A MEDICINAL CREAM MADE USING SILVER SULPHADIAZINE AND CHITOSAN AND A PROCESS TO MAKE IT

Publication No: WO2010/119369
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 9/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of silver sulphadiazine used in treating bacterial skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ing...


Title: A MEDICINAL CREAM MADE USING MICONAZOLE NITRATE AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119368
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 31/415 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antifungal active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of miconazole nitrate used in treating fungal skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, n...


Title: A MEDICINAL CREAM MADE USING HYDROCORTISONE ACETATE AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119367
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 47/36 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of hydrocortisone acetate, used in treating skin inflammation c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and a corticos...


Title: A MEDICINAL CREAM MADE USING FLUTICASONE PROPIONATE, AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119366
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of fluticasone propionate, used in treating skin inflammation c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and a corticos...


Title: A MEDICINAL CREAM MADE USING CLOTRIMAZOLE AND CHITOSAN AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119365
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 9/107 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating fungal skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antifungal active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of clotrimazole used in treating fungal skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co -solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely ...


Title: A MEDICINAL CREAM MADE USING NEOMYCIN SULPHATE, BETAMETHASONE VALERATE, AND CHITOSAN, AND A PROCESS TO MAKE THE SAME

Publication No: WO2010/119364
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61K 47/26 - VANANGAMUDI, Sulur, Subramaniam
The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), neomycin sulphate & betamethasone valerate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co- solvents, ac...


Title: PHARMACEUTICAL COMPOSITION COMPRISING GLYCEROL, WHITE SOFT PARAFFIN AND LIQUID PARAFFIN FOR THE TREATMENT OF UREMIC XEROSIS AND/OR PRURITUS

Publication No: WO2010/119132
Pub. Date - Int. Class - Applicant: - 21.10.2010 - A61P 17/16 - ORFAGEN
The invention relates to a pharmaceutical composition comprising a combination of glycerol, white soft paraffin and liquid paraffin as active ingredients for topical use to treat uremic xerosis and/or uremic pruritus.


Title: INDUCED PLURIPOTENT STEM CELLS

Publication No: WO2010/115052
Pub. Date - Int. Class - Applicant: - 07.10.2010 - C12N 5/074 - THE MCLEAN HOSPITAL CORPORATION
The present invention concerns the delivery of certain reprogramming factor proteins into cells, such as differentiated somatic cells, in order to induce the epi-genetic reprogramming of the cell so it becomes a pluripotent stem cell. The reprogramming factor protein(s) may be Sox2, Klf4, Oct3/4, c-Myc, Lin28, Nanog, or any protein with reprogramming (-enhancing) activity. These proteins may be linked recombinantly or chemically to a cell penetrating peptide that helps facilitate the introduction of these proteins into the target cell and may be preferably expressed in mammalian cells to maintain them in active forms. Accordingly, the present method of inducing pluripotent stem cell (iPS) formation avoids the use of viral or DNA-based expre...


Title: COMPOSITIONS AND METHODS FOR ALLEVIATING SKIN DISORDERS

Publication No: WO2010/111374
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/375 - BELLMAN, Betty
The disclosure relates to the discovery that fractionated coconut oil is effective for alleviating existing skin disorders when applied topically to the skin of a person afflicted with such a disorder. The disclosure further relates to the discovery that fractionated coconut oil can be used to prevent or inhibit onset of a skin disorder or to reduce the severity of a skin disorder when administered prophylactically to the skin of a person. A variety of skin-active ingredients can be included in the composition, in addition to fractionated coconut oil.


Title: A MEDICINAL ANTIBACTERIAL, ANTIFUNGAL AND STEROIDS CREAM COMPRISING CHITOSAN AND A PROCESS TO MAKE IT

Publication No: WO2010/109434
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating bacterial skin infections, fungal skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid, an antifungal and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections, fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active ingredients used in treating bacterial skin infections, fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-s...


Title: AN ANTIVIRAL MEDICINAL CREAM AND A PROCESS TO MAKE IT

Publication No: WO2010/109433
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/722 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating viral skin infections along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antiviral active ingredient. It discloses a composition for treating viral skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active ingredient used in treating viral skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and an antiviral agent, are incorporated in cream base for u...


Title: A MEDICINAL STEROIDS CREAM AND A PROCESS TO MAKE IT

Publication No: WO2010/109425
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and a corticosteroid. It discloses a composition for treating skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active ingredient such as a corticosteroid used in treating skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and a corticosteroid, are incorporated in cream base for u...


Title: A MEDICINAL ANTIBACTERIAL AND STEROIDS CREAM COMPRISING CHITOSAN AND A PROCESS TO MAKE IT

Publication No: WO2010/109424
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/415 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs) used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, c...


Title: A MEDICINAL ANTIFUNGAL AND STEROIDS CREAM COMPRISING CHITOSAN AND A PROCESS TO MAKE IT

Publication No: WO2010/109423
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/57 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antifungal active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs) used in treating fungal skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating age...


Title: A MEDICINAL ANTIFUNGAL AND STEROIDS CREAM COMPRISING CHITOSAN AND A PROCESS TO MAKE IT

Publication No: WO2010/109421
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 31/496 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating fungal skin infections particularly dandruff, along with skin/scalp rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antifungal/antidandruff active ingredient. It discloses a composition for treating fungal skin infections particularly dandruff, along with skin/scalp rejuvenation containing a) a biopolymer in the form of Chitosan, b) an active pharmaceutical ingredient (API) alone or in combination used in treating fungal skin infections particularly dandruff related, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants,...


Title: A MEDICINAL ANTIFUNGAL CREAM AND A PROCESS TO MAKE IT

Publication No: WO2010/109418
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 8/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating fungal skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antifungal active ingredient. It discloses a composition for treating fungal skin infections, along with skin rejuvenation containing a) a biopolymer in the form of Chitosan, b) an active pharmaceutical ingredient (API) used in treating fungal skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co- solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and an anti fungal agent, are in...


Title: A MEDICINAL ANTIBACTERIAL CREAM AND A PROCESS TO MAKE IT

Publication No: WO2010/109417
Pub. Date - Int. Class - Applicant: - 30.09.2010 - A61K 8/06 - VANANGAMUDI, Sulur, Subramaniam
The present invention relates to a composition for treating bacterial skin infections along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections along with skin rejuvenation containing a) a biopolymer in the form of a) chitosan, b) an active pharmaceutical ingredient (APIs) used in treating bacterial skin infections,. c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The active ingredients, namely chitosan, and an antibacteri...


Title: PERSONAL-CARE COMPOSITION COMPRISING OIL-SOLUBLE SOLID SUNSCREENS

Publication No: WO2010/108085
Pub. Date - Int. Class - Applicant: - 23.09.2010 - A61K 8/06 - THE PROCTER &GAMBLE COMPANY
In one embodiment, a personal-care composition in the form of a water-in-oil emulsion comprises at least about 10% of a non-polar silicone oil; from about 0.1% to about 10% of a first oil-soluble solid sunscreen; and from about 0.1% to about 10% of a second oil-soluble solid sunscreen. The weight ratio of the first sunscreen to the second sunscreen may be from about 0.8 to about 2.0, or from about 1.0 to about 1.5. The first sunscreen may be oxybenzone. The second sunscreen may be avobenzone. The composition may further comprise a skin-care active selected from the group consisting of a vitamin B3 compound, a sugar amine, a peptide, a hexamidine compound, and combinations thereof. In another embodiment, the invention relates to a method for...


Title: SCELETIUM EXTRACT AND USES THEREOF

Publication No: WO2010/106495
Pub. Date - Int. Class - Applicant: - 23.09.2010 - A61K 36/185 - H.L. HALL &SONS LIMITED
A composition including as an active ingredient an extract of a plant of the family Mesembryanthemaceae with mesembrenol and mesembrenone as the two major alkaloids present. The invention also relates to the use of the composition as a PDE4 inhibitor and as a serotonin-uptake inhibitor, preferably applied in formulations for the use of the composition as a dual serotonin-uptake inhibitor and PDE4 inhibitor. The invention extends to compositions, such as pharmaceutical compositions or compositions used as dietary supplements, the total alkaloid content of which includes at least 80% (w/w) combined content of mesembrenol and mesembrenone, less than 5%(w/w) mesembrine, and at least 7 % (w/w) mesembranol.


Title: COSMETIC BASIC COMPOSITION AND ITS USE

Publication No: WO2010/103008
Pub. Date - Int. Class - Applicant: - 16.09.2010 - A61K 8/73 - COTY DEUTSCHLAND GMBH
The present invention relates to a cosmetic basic composition comprising hydroxypropylmethylcellulose (HPMC) modified with C15-C20 alkyl ether groups as thickener, Oleosomes and water, wherein the Oleosomes comprise at least one cosmetically active substance. The invention also relates to the use of the cosmetic basic composition in products of decorative cosmetics, personal care cosmetics and/or skin protection cosmetics.


Title: METHOD AND COMPOSITION FOR EVENLY APPLYING WATER SOLUBLE ACTIVES

Publication No: WO2010/102938
Pub. Date - Int. Class - Applicant: - 16.09.2010 - A61K 8/891 - UNILEVER PLC
A method and composition for evenly applying water soluble actives is described. The method includes applying a composition with a HIPE to skin and generating a film having a hydrophilic surface so that composition and active can be evenly applied.


Title: COMPOSITION FROM SPHAERANTHUS INDICUS AND GARCINIA MANGOSTANA FOR THE CONTROL OF METABOLIC SYNDROME

Publication No: WO2010/100653
Pub. Date - Int. Class - Applicant: - 10.09.2010 - A61K 36/00 - LAILA NUTRACEUTICALS
The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve g...


Title: PEPTIDES DERIVED FROM FICOLIN AS SURFACTANTS

Publication No: WO2010/100646
Pub. Date - Int. Class - Applicant: - 10.09.2010 - C07K 14/47 - METAMOREFIX LTD.
The invention provides use of a peptide having a sequence that is a subsequence of a ficolin protein as a surfactant. The peptide may be a subsequence of human ficolin in which case it is essentially non-toxic. The invention also provides a pharmaceutical composition comprising a surfactant wherein the peptide has a sequence that is a subsequence of a ficolin protein as a surfactant. The pharmaceutical composition can comprise an active ingredient for delivery through a body surface such as skin.


Title: DELIVERY SYSTEM WITH SCAFFOLDS

Publication No: WO2010/100506
Pub. Date - Int. Class - Applicant: - 10.09.2010 - A61K 9/00 - REGENTEC LIMITED
An injectable, agent delivery system comprising a composition comprising: (i) an injectable scaffold material comprising discrete particles, which are capable of interacting to form a scaffold; and (ii) a carrier comprising an agent for delivery. The product can have a pharmaceutical use or use in cosmetic surgery; in particular it can be used in tissue regeneration or reconstruction. The agent for delivery may be a therapeutically, prophylactically or diagnostically active substance.


Title: REDUCTION OF CELLULITE

Publication No: WO2010/098872
Pub. Date - Int. Class - Applicant: - 02.09.2010 - A01N 35/02 - HILL, John, R.
Described are topical cosmetic compositions for use in reducing the appearance of cellulite on a subject, the topical composition consisting of: from about 5% to about 25% by volume one or more low boiling point alcohols, from about 0% to about 20% one or more cooling sensate by volume, and from about 50% to about 75% water by volume; wherein the concentration of any single cooling sensate is a maximum of 10% of the topical composition. Also described are methods for reducing at least the appearance of cellulite on a body part of a subject, the method comprising: topically applying to the body part associated with cellulite a composition comprising an active ingredient and an inactive ingredient or ingredients, wherein the active ingredient...


Title: COMPOSITION FOR SKIN EXTERNAL APPLICATIONCONTAINING RED PINE ROOT EXTRACT

Publication No: WO2010/098595
Pub. Date - Int. Class - Applicant: - 02.09.2010 - A61K 8/97 - AMOREPACIFIC CORPORATION
The present invention relates to a composition for skin external application containing a pine root extract. More specifically, the composition for skin external application according to the present invention contains, as an active ingredient, a pine root extract which shows various effects, including eliminating free radicals, protecting the cell membrane from damage by UV radiation, inhibiting the production of reactive oxygen species caused by UV radiation, inhibiting the reduction in the expression of superoxide dismutase (SOD) and catalase caused by UV radiation, stimulating the production of HSP70 to protect cells, inhibiting MMP-2 biosynthesis caused by UV radiation, inducing the expression of SIRT1 gene that restores DNA damage, and...


Title: TOPICAL OR TRANSDERMAL DELIVERY KIT

Publication No: WO2010/097773
Pub. Date - Int. Class - Applicant: - 02.09.2010 - A61K 9/70 - LISZIEWICZ, Julianna
The invention relates to delivery devices and methods using the dermal/topical and transcutaneous/transdermal route being applicable in the fields of therapy cosmetics and esthetics, and uses thereof for topical or transdermal delivery of a wide variety of effective agents like preventive and therapeutic vaccines, nanoparticle based medicines, drugs and cosmetic substances. More particularly, the invention provides specially designed, empty patch based delivery kits suitable for non-invasive transdermal delivery of active substances being in liquid or gel like form, said kits being especially useful for targeting epidermal Langerhans cells and, thereby, draining lymph nodes.


Title: COMPOSITION OF A LIPOSOMAL GEL CONTAINING HYDROCORTISONE, ITS METABOLITES, PRECURSORS OR MIXTURES THEREOF AND THE USE THEREOF

Publication No: WO2010/096886
Pub. Date - Int. Class - Applicant: - 02.09.2010 - A61K 9/127 - VAN BOGAERT, Gina
Liposomal gel which, apart from liposomes and a continuous phase, comprises at least one thickening agent, at least one biologically active material and, optionally, at least one additive, whereby the biologically active material is encapsulated in the liposomes, and whereby this material consists of hydrocortisone, its metabolites or precursors, or a mixture thereof, and is applied on the skin for therapeutic purposes, characterised in that the weight ratio phosphatidylcholine/hydrocortisone amounts to at least 2/1 and/or in that the weight ratio phosphatidylcholine/carbomer hydrogel amounts to at least 20/1.


Title: TOPICAL FOAM COMPOSITION

Publication No: WO2010/096868
Pub. Date - Int. Class - Applicant: - 02.09.2010 - A61K 9/107 - STIEFEL RESEARCH AUSTRALIA PTY LTD
The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.


Title: FOAMABLE MICROEMULSION COMPOSITIONS FOR TOPICAL ADMINISTRATION

Publication No: WO2010/093523
Pub. Date - Int. Class - Applicant: - 19.08.2010 - A61K 9/12 - COLLEGIUM PHARMACEUTICAL, INC.
Described are ethanol-free foamable microemulsions for topical application, and method of making them. The propellants used in the compositions may be environmentally-friendly hydrofluoroalkanes. The foam compositions may also comprise one or more of a variety of active ingredients, including anti-inflammatory agents, anesthetics, and keratolytic agents.


Title: A CATIONIC PHARMACEUTICALLY ACTIVE INGREDIENT CONTAINING COMPOSITION, AND METHODS FOR MANUFACTURING AND USING

Publication No: WO2010/091274
Pub. Date - Int. Class - Applicant: - 12.08.2010 - A61K 9/14 - SKINVISIBLE PHARMACEUTICALS, INC.
A cationic pharmaceutically active ingredient containing composition is provided. The composition includes a cationic pharmaceutically active ingredient, a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone/alkylene) polymer and a polymer comprising carboxylic acid groups, hydroxyl groups, or a mixture of carboxylic acid groups and hydroxyl groups, a compatibilizing amount of a long chain organic acid having a carbon chain of at least 8 carbon atoms, and at least about 50 wt.% water.


Title: COSMETIC SKIN LIGHTENING AGENT AND COMPOSITION THEREOF

Publication No: WO2010/089754
Pub. Date - Int. Class - Applicant: - 12.08.2010 - A61Q 19/02 - CAVINKARE PVT. LTD
Improved cosmetic compositions for lightening the colour of the skin wherein the active ingredient comprises a protocatechuic acid derivative of Formula (I) or preferably a protocatechuic acid derivative, Oreganol A of Formula (II) in an effective amount along with cosmetically acceptable vehicles with or without skin benefit agents. The active ingredient is selectively isolated from the plant parts of Origanum vulgare Linn.


Title: REGULATION OF MAMMALIAN KERATINOUS TISSUE USING SKIN AND/OR HAIR CARE ACTIVES

Publication No: WO2010/088225
Pub. Date - Int. Class - Applicant: - 05.08.2010 - A61K 8/60 - THE PROCTER &GAMBLE COMPANY
Personal care compositions containing an active selected from the group consisting of phlorogine, phlorgine BG, deoxyArbutin, sucrose dilaurate, bakuchiol, pyrenoine, millet, arlatone dioic acid, cinnamic acid, ferulic acid, achromaxyl, methyl nicotinamide, oil soluble licorice extract, folic acid, undecylenic acid, zinc undecylenate, L-tryptophan, thiamine HCl, hexylresorcinol, lipidami red vine, dragosine, methyl gentisate, inositol, symdiol 68, laminaine, their salts, their derivatives, their precursors, and/or combinations thereof. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.


Title: COMPOSITIONS FOR NAIL AND SKIN TREATMENT

Publication No: WO2010/086726
Pub. Date - Int. Class - Applicant: - 05.08.2010 - A61K 9/127 - YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Novel topical compositions for the treatment of nail and skin afflictions comprising at least one active, excluding terbinafine, at least one volatile solvent, at least one film-forming ingredient and at least one phospholipid, processes for their preparation and methods of treatment of nail and skin afflictions. Following application of the compositions and evaporation of volatile solvents, the composition produces a film, which has web-like structures containing the active(s).


Title: COMPOSITIONS FOR NAIL AND SKIN TREATMENT

Publication No: WO2010/086725
Pub. Date - Int. Class - Applicant: - 05.08.2010 - A01N 33/02 - YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
Provided are novel topical compositions for the treatment of nail and skin afflictions comprising terbinafine and/or terbinafine salt(s), at least 61% (w/w) of one or more volatile solvents, one or more film-forming ingredients and one or more phospholipids, processes for their preparation and methods of treatment of nail and skin afflictions. After application of the compositions of the invention on a nail or skin surface, following evaporation of volatile solvents, the composition forms a film, which exhibits web-like structures containing the active(s).


Title: SKIN-CARE COMPOSITION COMPRISING DILL EXTRACT

Publication No: WO2010/085532
Pub. Date - Int. Class - Applicant: - 29.07.2010 - A61K 8/97 - THE PROCTER &GAMBLE COMPANY
A skin-care composition may comprise a dill extract, a safe and effective amount of a peptide, a safe and effective amount of a hydrating skin active, and a dermatologically acceptable carrier. The skin-care composition may further comprise a safe and effective amount of an acute skin-care active. Further, a method of producing a chronic skin-firming benefit and, optionally, an acute skin-tightening sensation, said method comprising the step of topically applying to the skin of a mammal in need of such treatment, a safe and effective amount of the skin-care composition.


Title: TOPICAL COMPOSITION

Publication No: WO2010/082024
Pub. Date - Int. Class - Applicant: - 22.07.2010 - A61K 8/34 - RECKITT &COLMAN (OVERSEAS) LIMITED
A topical composition comprising at least one active agent selected from a depilatory agent (s), an agent (s) for preventing or reducing the growth or re-growth of hair and an agent (s) for preventing or reducing in-growing hair, and a gas, wherein the at least one active agent and gas are dispersed in a cosmetically acceptable medium.


Title: ANTIPERSPIRANT STICK COMPOSITION

Publication No: WO2010/081886
Pub. Date - Int. Class - Applicant: - 22.07.2010 - A61K 8/891 - COTY DEUTSCHLAND GMBH
The present invention relates to an antiperspirant cosmetic composition for topical application to the skin comprising an effective amount of at least one antiperspirant active material, at least one gelling agent, at least one wax and at least one solvent for the at least one antiperspirant active material, wherein the at least one gelling agent is obtainable by the in-situ reaction of a siloxane polymer with at least two hydroxy-functionalized terminal groups or hydroxy-functionalized side chains and a polyol with at least two hydroxyl groups, a hydrosiloxane with at least two Si-H units and a catalyst.


Title: ACNE TREATMENT POWDER FOUNDATION

Publication No: WO2010/077971
Pub. Date - Int. Class - Applicant: - 08.07.2010 - A61K 31/60 - HARMONY LABORATORIES, INC.
Dry powder foundation formulations that include a sustained-release salicylic acid composition, an effective, buffering amount of one or more salicylate ions, and one or more of zinc and titanium oxides, and pigments or colorants, are disclosed. The formulations provide both acne treatment and prevention, and sunblock protection. The formulation can also include other sunblocking or sunscreen agents to prevent photoaging and sunburn, such as avobenzone, and 3-benzophenone, and other cosmetically-acceptable active agents and excipients.


Title: TOPICAL HERBAL FORMULATION FOR TREATMENT OF ACNE AND SKIN DISORDERS

Publication No: WO2010/076812
Pub. Date - Int. Class - Applicant: - 08.07.2010 - A61K 9/107 - SUNEV PHARMA SOLUTION LIMITED
The present invention provides novel herbal nano emulsion based formulations comprising a combination of lemon juice and /or rose water as therapeutically active aqueous phase entrapped in oil phase selected from one or more essential oils and process for the preparation of the same in pharmaceutically acceptable dosage forms for topical treatment of acne and other skin disorder like eczema, psoriasis, aging scaring and the like with increased efficacy, Improved percutaneous penetration, excellent thermodynamic stability ensuring long shelf life, low skin irritation and reservoir effect that promotes drug localization in the skin enabling controlled delivery of the said therapeutic agents.


Title: TOPICAL SYSTEMS AND KITS

Publication No: WO2010/076803
Pub. Date - Int. Class - Applicant: - 08.07.2010 - A61K 8/25 - SOL-GEL TECHNOLOGIES LTD.
The present invention relates to a multi component topical system comprising at least one component comprising at least one first active agent coated by metal oxide; and at least one skin treating component free of said active agent. The invention further relates to methods of using said multi component topical system and kits comprising them.


Title: VITAMIN D PROMOTING SUNSCREEN

Publication No: WO2010/076731
Pub. Date - Int. Class - Applicant: - 08.07.2010 - A61K 31/4184 - ARMSTRONG, Ernest, T.
A composition suitable for providing protection against ultraviolet radiation containing one or more active ultraviolet radiation absorber through which ultraviolet B radiation is permitted to enter the skin in an amount sufficient for the body to produce a healthful and disease-opposing quantity of vitamin D3 and chemical precursors thereof. The composition is particularly used in sunscreens promoting on the one hand vitamin D3 production, on the other hand protecting the skin against harmful ultraviolet radiation.


Title: USE OF A FOAMABLE COMPOSITION ESSENTIALLY FREE OF PHARMACEUTICALLY ACTIVE INGREDIENTS FOR THE TREATMENT OF HUMAN SKIN

Publication No: WO2010/072422
Pub. Date - Int. Class - Applicant: - 01.07.2010 - A61K 9/12 - INTENDIS GMBH
The present invention related to the use of a pharmaceutical composition which is esentially free of pharmaceutically active ingredients for the treatment of human skin, especially in the treatment of rosacea, acne, atopic dermatitis, contact dermatitis, perioral dermatitis, psoriasis or neurodermitis.


Title: TOPICAL COMPOSITIONS COMPRISING AT LEAST ONE ACTIVE INGREDIENT POORLY SOLUBLE IN WATER AND BIOPOLYMERS SUCH AS HYALURONIC ACID WITH A PKA-VALUE BETWEEN 5-7

Publication No: WO2010/069519
Pub. Date - Int. Class - Applicant: - 24.06.2010 - A61K 9/70 - MERZ PHARMA GMBH &CO. KGAA
The present invention relates to compositions comprising one or more active ingredients poorly soluble in water and an biopolymer having at least one carboxylic group, selected from acid polysaccharides such as hyaluronic acid, alginic acid, polymaleic acid or a derivative thereof having a pKa-value of between 5 and 7 in a water or water - alcoholic mixture. Surprisingly such active ingredients remain in a suitable (solvated) form in the composition without rapid crystallisation of the active/s. Moreover when topically applied to skin or parts thereof, e.g. nails, hair and scalp in need of a treatment, the compositions as described surprisingly form an essentially anti-abrasive film which can be removed by action of water. The compositions ...


Title: A COMPLEX OF ACTIVE VEGETAL STEM CELLS AND A COSMETIC COMPOSITION

Publication No: WO2010/067212
Pub. Date - Int. Class - Applicant: - 17.06.2010 - A61K 8/97 - LABO COSPROPHAR AG
The present invention refers to a complex of vegetal source active stem cells, including stem cells of Malus Domestica, stem cells of Buddleja Davidii amd preferably Teprenone, and to a cosmetic composition for topical use, which contains such complex. The complex of stem cells with Teprenone and the cosmetic composition of the invention perform a regenerating action and a repairing action on the skin cell layers, increasing vitality and longevity of the skin and hair follicle.


Title: DEPILATORY COMPOSITION

Publication No: WO2010/064017
Pub. Date - Int. Class - Applicant: - 10.06.2010 - A61K 8/46 - RECKITT &COLMAN (OVERSEAS) LIMITED
A depilatory cream composition comprising a depilatory active, and one or more volatile, essential oils selected from the group consisting of orange oil, cedarwood oil, patchouli oil, pine oil, cabreuva oil, guaiacwood oil, lavandin oil, bergamot oil, petitgrain paraguay oil, lavender oil, mint oil, Virginia cedarwood oil, Citrus Aurantium dulcis oil and Citrus grandis oil.


Title: IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION

Publication No: WO2010/060104
Pub. Date - Int. Class - Applicant: - 27.05.2010 - A61K 51/12 - MOMA THERAPEUTICS
In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcripti...


Title: COSMETIC COMPOSITIONS

Publication No: WO2010/059466
Pub. Date - Int. Class - Applicant: - 27.05.2010 - A61K 8/893 - THE PROCTER &GAMBLE COMPANY
A cosmetic composition comprises a) from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer; b) from about 0.1% to about 10% of a noncrosslinked silicone emulsifier having a polyglycerin unit; c) from about 1% to about 50% of a solvent for the emulsifying crosslinked siloxane elastomer; d) from about 0.05% to about 10% of an amphiphilic active; and e) water.


Title: COSMETIC COMPOSITION CONTAINING EXTRACTS OF ADENOPHORA TRIPHYLLA VAR. JAPONICA HARA, ANGELICA TENUISSIMA AND MEDICINAL HERBS

Publication No: WO2010/058986
Pub. Date - Int. Class - Applicant: - 27.05.2010 - A61K 8/97 - AMOREPACIFIC CORPORATION
Disclosed herein is a cosmetic composition containing, as an active ingredient, a mixture of extracts of honey-roasted Adenophora triphylla var. japonica Hara and honey-roasted Angelica tenuissima Nakai, processed using a medicinal herb processing technique, and of extracts of medicinal herbs such as Lycium chinense Mill or Paeonia suffruticosa, and thus shows excellent antioxidant and skin-moisturizing effects.


Title: SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHO-DIHYDROXYISOFLAVONE DERIVATIVES

Publication No: WO2010/058936
Pub. Date - Int. Class - Applicant: - 27.05.2010 - A61K 31/366 - AMOREPACIFIC CORPORATION
Disclosed herein is a skin external composition for inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases, which contains ortho-dihydroxyisoflavone derivatives as an active ingredient. Specifically, the skin external composition contains the ortho-dihydroxyisoflavone derivatives, 4',6,7-trihydroxyisoflavone, 3',4',7-trihydroxyisoflavone or a mixture thereof, and thus increases the expression of DKK3 protein and FZD1 protein, which appropriately control Wnt signaling, thereby inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases caused by epidermal hyperproliferation.


Title: HOMEOPATHIC COMPOSITION COMPRISING HYPERICUM PERFORATUM EXTRACT AND ESSENTIAL OILS FOR THE TREATMENT OF NEUROPATHIC PAIN

Publication No: WO2010/057295
Pub. Date - Int. Class - Applicant: - 27.05.2010 - A61K 36/714 - ORIGIN BIOMED INC.
The present invention provides a method of treating neuropathic pain by administering a topical homeopathic composition to a mammalian subject. The homeopathic formulation contains homeopathic active ingredients comprising Hypericum perforatum in a base of essential oils which facilitate delivery of the homeopathic ingredient through the skin.


Title: POLYNUCLEOTIDES ENCODING A HUMAN TRIM-CYP FUSION POLYPEPTIDE, COMPOSITIONS THEREOF, AND METHODS OF USING SAME

Publication No: WO2010/054141
Pub. Date - Int. Class - Applicant: - 14.05.2010 - C07H 21/04 - THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
A nucleic acid is provided which encodes a human TRIM-cyclophilin A fusion sequence encoding a human TRIM-CypA fusion protein which is active as an anti-viral agent, and in particular, as an anti-HIV-1 agent. Also provided is a nucleic acid encoding a polypeptide having both TRIM activity and cyclophilin activity. Also provided is an isolated polynucleotide encoding a human TRIM-CypA fusion protein, or variants thereof retaining the TRIM and cyclophilin A activities. Also provided are compositions thereof, antibodies that specifically bind thereto, and vectors and host cells comprising the nucleic acid or polypeptide. In addition, methods are provided for treating or preventing viral infection, or reducing viral load in a subject comprising...


Title: METHOD FOR THE PREPARATION OF MEDICAL DEVICES AND DEVICES OBTAINED THEREFROM

Publication No: WO2010/052568
Pub. Date - Int. Class - Applicant: - 14.05.2010 - A61K 36/482 - ABOCA S.P.A. SOCIETA' AGRICOLA
Method of selecting and preparing medical devices comprising extracts of plants and natural substances devoid of pharmacologically, immunologically or metabolically active fractions and characterised by a content of substances able to exert beneficial effects on the body, mediated by mechanical or physical effects, which said process comprises: a) removal by conventional processes of any pharmacologically, immunologically or metabolically active fractions from extracts of plants or natural substances; b) biological testing to establish that the extract or substance obtained in a) is devoid of pharmacological, metabolic and immunological effects; c) formulation of the extracts or substances that pass the test conducted at stage b) into suita...


Title: THE USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

Publication No: WO2010/052329
Pub. Date - Int. Class - Applicant: - 14.05.2010 - A61K 31/045 - GIULIANI S.P.A.
The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5a-reductase. This is a novel use of compounds of general Formula (I): CH3 (-CH=CH)n-R (I) where n = from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O-CO-R', CO-O(-), where R' is chosen from among H, and the alky from C1 to C22, each compound of general Formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5a-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.


Title: DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

Publication No: WO2010/052328
Pub. Date - Int. Class - Applicant: - 14.05.2010 - A61K 31/045 - GIULIANI S.P.A.
The present invention relates to a novel use of compounds having the general formula (I): CH3(-CH=CH)n-R (I) where n = from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O-CO-R', CO-OR', CO-O(-), where R' is chosen from among H, the alkyl from C1 to C22, each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.


Title: BROAD SPECTRUM MICROBICIDAL AND SPERMICIDAL COMPOSITIONS AND METHODS

Publication No: WO2010/050955
Pub. Date - Int. Class - Applicant: - 06.05.2010 - A61K 31/40 - ESAWTECH, LTD.
The present invention relates to microbicidal and spermicidal compositions, methods and topical pharmaceutical compositions containing N-cocoyl amino acid pyrrolidone carboxylates (N-cocoyl amino acid pyrrolidone salts, CAPS) as active ingredients. The invention is for the prevention and control of sexually transmitted diseases and for the prevention of pregnancy. The microbicidal spectrum of the invention includes various STD pathogens, HIV viruses as well as gram positive and negative bacteria, and yeasts. Spermicidal barriers containing the compositions are also provided. The N-cocoyl amino acid pyrrolidone salts is represented by the formula: Wherein A is an amino acid residue and R is a C.sub.10 -C.sub.14 fatty acid residue.


Title: CHAMOMILLA EXTRACT FOR THE TREATMENT OF HYPERTENSION

Publication No: WO2010/049808
Pub. Date - Int. Class - Applicant: - 06.05.2010 - A61K 36/28 - AL-DABOONI, Rafida, Mohammed, Ahmed
The present invention is directed to a composition for the treatment of hypertension and/or of the symptoms associated with hypertension and/or of diseases caused by hypertension. This composition consists of an extract of at least one Chamomilla plant as the only active principle.


Title: STRUCTURED COMPOSITION COMPRISING AN ENCAPSULATED ACTIVE

Publication No: WO2010/048154
Pub. Date - Int. Class - Applicant: - 29.04.2010 - C11D 3/20 - THE PROCTER &GAMBLE COMPANY
A structured liquid composition having a liquid matrix having water and a fibrous network structurant, the fibrous network structurant having a non-polymeric crystalline hydroxyl-functional materials; a bacterial cellulose network; and mixtures thereof; and an encapsulated active. The encapsulated active is suspended within the liquid matrix of the structured liquid composition such that the encapsulated actives do not undesirably sink, float, or collect in any discrete portion of the composition. Further, the structured liquid composition can be in the form of a raw material such as an encapsulated active slurry, in the form of an additive such as a laundry additive, and as a consumer end product. In one embodiment, the encapsulated active...


Title: COMPOSITION FOR TREATMENT OF EPITHELIAL TISSUE

Publication No: WO2010/046861
Pub. Date - Int. Class - Applicant: - 29.04.2010 - A61K 9/54 - NOVODERMIX INTERNATIONAL LIMITED
A pharmaceutical composition is provided. The composition is a topical oil-in-water formulation which includes a GABA agonist such as topiramate as the active ingredient.


Title: A TOPICAL COMPOSITION COMPRISING EXTRACTS OF A. INDICA AND M. CHARANTIA OR S. INDICUM

Publication No: WO2010/046316
Pub. Date - Int. Class - Applicant: - 29.04.2010 - A61K 36/185 - UNILEVER NV
The invention relates to a topical composition and a method for reducing or preventing occurrence of acne on the skin. It is an object of the present invention to provide for a combination of herbal extracts that interact synergistically to provide a cosmetic composition for prevention, reduction or treatment of acne. The present invention provides for a topical composition comprising (i) an extract of a first active which is Azhadirachta indica; and (ii) an extract of a second active selected from Momordica charantia or Sesamum indicum.


Title: COSMETIC AND TOPICAL USE OF XANTHOHUMOL INCLUDING BRIGHTENING SKIN COMPLEXION AND REDUCING CUTANEOUS REDNESS

Publication No: WO2010/044076
Pub. Date - Int. Class - Applicant: - 22.04.2010 - A61K 8/35 - SEDERMA
The subject matter of the présent invention is the cosmetic and topical use of xanthohumol as active ingrédient, including inhibiting the GMCSF production for brightening complexion and/or reducing cutaneous redness.


Title: USE OF DIANHYDROHEXITE MONONITRATE DERIVATIVES AS HEALING AGENTS

Publication No: WO2010/043550
Pub. Date - Int. Class - Applicant: - 22.04.2010 - A61K 31/34 - LACER, S.A.
The present invention relates to the use of a compound of formula (I) or a tautomer, a pharmaceutically acceptable salt or a solvate thereof as active ingredient(s) in the manufacture of a pharmaceutical composition to heal wounds.


Title: LIPOSOMAL SYSTEMS COMPRISING SPHINGOMYELIN

Publication No: WO2010/041255
Pub. Date - Int. Class - Applicant: - 15.04.2010 - A61K 9/127 - YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
The present disclosure provides a liposomal system comprising an aqueous medium having dispersed therein liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the aqueous medium being in iso-osmotic equilibrium with said intraliposomal aqueous compartment, the liposomes having a membrane comprising a liposome forming lipids, at least one of which being sphingomyelin (SPM), the liposomal system having increased stability as compared to the same liposomes free of SPM, and in one embodiment being stable during long-term storage, said stability being characterized in that no more than 30% of the at least one active agent is present in the aqueous medium after said storage. Further provided by the present...


Title: OIL-BASED FOAMABLE CARRIERS AND FORMULATIONS

Publication No: WO2010/041141
Pub. Date - Int. Class - Applicant: - 15.04.2010 - A61K 9/12 - FOAMIX LTD.
A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.


Title: ACTIVE AGENT LOADED UNIFORM, RIGID, SPHERICAL, NANOPOROUS CALCIUM PHOSPHATE PARTICLES AND METHODS OF MAKING AND USING THE SAME

Publication No: WO2010/039560
Pub. Date - Int. Class - Applicant: - 08.04.2010 - A61K 9/14 - LABORATORY SKIN CARE, INC.
Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.


Title: METHODS OF MEASURING HUMAN BODY FREQUENCIES OR HARMONICS AND TREATING CONDITIONS BASED ON THE RESONANCE PHENOMENON BETWEEN A PRODUCT AND A HUMAN BODY'S FREQUENCIES OR HARMONICS

Publication No: WO2010/039465
Pub. Date - Int. Class - Applicant: - 08.04.2010 - A61B 5/055 - ELC MANAGEMENT LLC
A method for measuring in real-time the frequency and the power of an electromagnetic ("EM") field emitted by a human body for different body conditions, the resonance phenomenon between the EM fields emitted by various products or electronic devices and the EM field emitted by a human body, and the signals emitted by active materials, waters, topical products, etc. A first real time spectrum analyzer is connected to a broad frequency range antenna placed in contact with the skin, electromagnetic fields emitted by a particular condition of the subject human body are measured to reveal peaks of power, and a second narrow frequency antenna is used to measure the peak more accurately. A product is applied to the condition, and a seco...


Title: TRANSDERMAL EXTENDED-DELIVERY DONEPEZIL COMPOSITIONS AND METHODS FOR USING THE SAME

Publication No: WO2010/039381
Pub. Date - Int. Class - Applicant: - 08.04.2010 - A61K 31/445 - TEIKOKU PHARMA USA, INC.
A transdermal extended-delivery donepezil active agent composition is provided. Aspects of the compositions of the invention include a donepezil active agent layer that is formulated to provide for multi-day delivery of a therapeutically effective amount of a donepezil active agent to a subject when the composition is topically applied to the subject. Also provided are methods of using the formulations, e.g., for administering a donepezil active agent to a subject, and kits containing the formulations.


Title: NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS

Publication No: WO2010/037514
Pub. Date - Int. Class - Applicant: - 08.04.2010 - A61K 39/00 - IMMATICS BIOTECHNOLOGIES GMBH
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.


Title: COMPOSITION OF TUMOR-ASSOCIATED PEPTIDES AND RELATED ANTI-CANCER VACCINE FOR THE TREATMENT OF GLIOBLASTOMA (GBM) AND OTHER CANCERS

Publication No: WO2010/037513
Pub. Date - Int. Class - Applicant: - 08.04.2010 - A61K 39/00 - IMMATICS BIOTECHNOLOGIES GMBH
The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.


Title: LIPID BASED PHARMACEUTICAL PREPARATIONS FOR ORAL AND TOPICAL APPLICATION; THEIR COMPOSITIONS, METHODS, AND USES THEREOF

Publication No: WO2010/036947
Pub. Date - Int. Class - Applicant: - 01.04.2010 - A61K 47/44 - ALI, Shoukath M.
The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least ...


Title: NOVEL PALMITOYLTRIPEPTIDE AND ANTI-WRINKLE COSMETIC COMPOSITION CONTAINING IT

Publication No: WO2010/032891
Pub. Date - Int. Class - Applicant: - 25.03.2010 - C07K 5/00 - MAIM CO., LTD.
Disclosed are a novel palmitoyltripeptide compound and an anti-wrinkle cosmetic composition comprising the same as an active ingredient. Having the ability to effectively pass through the skin barrier thanks to the lipophilic moiety thereof, the novel compound shows great improvements in skin wrinkles and elasticity. Also, the compound can promote the synthesis of collagen in wounded skin tissues, providing excellent skin rejuvenation properties.


Title: GELATINOUS ELASTOMER COMPOSITIONS

Publication No: WO2010/030824
Pub. Date - Int. Class - Applicant: - 18.03.2010 - B32B 27/00 - SILIPOS, INC.
The present invention is directed to gelatinous elastomer compositions that are useful for topical application of biologically active agents. In certain embodiments, the invention is directed to a gelatinous elastomer composition comprising about 1.0% to 50.0% block copolymer, about 0% to 98% mineral and/or synthetic oil, and about 0.0% to 98% triglyceride oil, about 0- 15.0% free fatty acids, about 0-30% of a tack modification agent, about 0-20.0% of a biologically active agent and, optionally a phytosterol, ceramide and/or bisabolol. The gelatinous elastomer compositions are useful for applying a biologically active agent to a mammal. In certain embodiments, the gelatinous elastomer composition is formed into a molded article.


Title: LOW PH RETINOID TOPICAL COMPOSITIONS

Publication No: WO2010/030636
Pub. Date - Int. Class - Applicant: - 18.03.2010 - A61K 9/16 - AMCOL INTERNATIONAL CORPORATION
A low pH composition containing a retinol and a method for treating skin is disclosed. The composition contains (a) a retinoid and (b) an active acid, like an alpha- hydroxy acid or a beta-hydroxy acid, and has a pH of less than 5.


Title: TRANSDERMAL DELIVERY OF OLIGOSACCHARIDES

Publication No: WO2010/029552
Pub. Date - Int. Class - Applicant: - 18.03.2010 - A61F 13/70 - TRANSPHARMA MEDICAL LTD.
The present invention relates to a system for facilitating transdermal delivery of oligosaccharides comprising an apparatus that generates micro-channels in the skin of a subject and a skin patch comprising a pharmaceutical composition comprising as an active agent an oligosaccharide. Particularly, the composition comprises an oligosaccharide of 5-20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.


Title: PYRIDINE DERIVATIVES AS VEGFR-2 RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS

Publication No: WO2010/022725
Pub. Date - Int. Class - Applicant: - 04.03.2010 - C07D 213/75 - LEO PHARMA A/S
The invention relates to compounds of general formula (I) wherein W, D, E, G, J, L, R1, R2, R3, R4, R5 and Y are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer and skin and eye diseases.


Title: FORMULATION BASED ON MICRONIZED CLINOPTILOLITE AS THERAPEUTIC AGENT PROVIDING HIGHLY BIOAVAILABLE SILICON

Publication No: WO2010/018418
Pub. Date - Int. Class - Applicant: - 18.02.2010 - C01B 33/00 - NOVATECH ISTRAZIVANJE d.o.o.
This invention relates to a formulation based on micronized clinoptilolite (MC) as therapeutic agent for effective release of highly bioavailable silicon. The formulation comprising variable portions of: (i) micronized clinoptilolite (MC) of general formula: (Men+)x/n[(AlO2)x(SiO2)y]-mH2O (MC) where Me= H, Li, Na, K, Mg, Ca, Zn, Ag, Cu, Mn, Fe; whereas ratio of silicon to aluminum, y:x is between 2.6:1 to 5: 1; number of crystalline water m is from 0 to 20, which is characterized by particles size from 500 nm to 5 µm; and of (ii) one or more excipients which yield in desired pharmaceutical form: tablets, capsules, ointments, creams, gels, lotions, shampoos, powders, liquid powders, compact powders, masks, suppositories, syrups, suspensions...


Title: A METHOD AND COMPOSITION FOR THE CONTROL OF ECTOPARASITES

Publication No: WO2010/018360
Pub. Date - Int. Class - Applicant: - 18.02.2010 - A01P 7/04 - THORNTON &ROSS LIMITED
An ectoparasiticidal composition is provided that comprises a mixture of a carrier and an active. The carrier comprises a mixture of a volatile siloxane and an essential oil and/or a derivative of an essential oil in an amount such that it is incapable of adding any significant insecticidal activity to the composition over that of the active. Preferably, the essential oil and/or the derivative of an essential oil comprises a terpene, in particilar nerolidol, or a phenylpropanoid derivative. These impart significant penetration enhancement of the active or actives of the ectoparasiticidal composition into the aeropyles of the target insects' ova.


Title: THERAPEUTIC COMPOSITIONS, DEVICES AND METHODS FOR OBSERVING TREATED TISSUES

Publication No: WO2010/017403
Pub. Date - Int. Class - Applicant: - 11.02.2010 - A61K 31/726 - IMMUNOPATH PROFILE, INC.
The present invention relates to a therapeutic composition and uses thereof for treatment of damaged tissue. The composition comprises at least one extracellular matrix compound, at least one polar surface active lipid, and a plurality of amino acids having a molar ratio which is characteristic of human breast milk protein. Composition therapeutics also comprises a plurality of amino acids having a molar ratio which is characteristic of human bowel protein and further comprises a fatty acid, gamma- amino butyric acid or L- carnitine. Using FDA approved-as-safe components equivalent to the components of human tissue, composition therapeutics is immunologically concordant with genetic 'self and the immuno-inflammatory barrier and thereby avoi...


Title: A COMPOSITION FOR IMPROVING SKIN CONDITION AND APPEARANCE

Publication No: WO2010/014861
Pub. Date - Int. Class - Applicant: - 04.02.2010 - A01N 31/00 - ARCH PERSONAL CARE PRODUCTS, L.P.
Disclosed is a cosmetic composition comprising prenylated isoflavonoid and a carrier, wherein the prenylated isoflavonoid is from about 0.0000001% to about 10%, preferably from 0.00001% to 1%, most preferably from 0.01% to 1%, by weight, based on the total weight of the composition. The active agent prenylated isoflavonoid induces a statistically significant upregulation of collagen IAl and elastin genes in normal human dermal fibroblasts. The composition is effective to stimulate the production of collagen and elastin and improve the appearance and condition of the skin.


Title: COSMETIC COMPOSITION FOR ANTI-AGING OF THE SKIN COMPRISING PHASEOLUS RADIATUS SEED EXTRACTS BY FERMENTATION AND ENZYME TREATMENT

Publication No: WO2010/013852
Pub. Date - Int. Class - Applicant: - 04.02.2010 - A61K 8/97 - COREANA COSMETICS, CO., LTD
Provided is a cosmetic composition for skin protection containing Phaseolus radiatus extract of fermentation-enzyme treatment, prepared by fermenting Phaseolus radiatus with Saccharomyces cerevisiae or Lactobacillus and treating thereof with protease as an active ingredient, and a make-up method using the same. The Phaseolus radiatus extract of fermentation-enzyme treatment of the present invention contains higher isoflavone and has activities of increasing skin cell activity, alleviating skin irritation, and accelerating synthesis of skin cell protein such as collagen, so that it brings the effect of improving skin troubles caused by aging and protecting skin as well.


Title: ARTICLE WITH REFRESHING OR WARMING EFFECT FOR USER

Publication No: WO2010/012750
Pub. Date - Int. Class - Applicant: - 04.02.2010 - A61F 7/10 - BORDONI, Claudio
An article with refreshing/warming effect for user is disclosed. Said article comprises a support that contains a composition comprising mineral salts and an active substance with refreshing/warming effect.


Title: TOPICAL ANTI-INFLAMMATORY COMBINATION

Publication No: WO2010/011541
Pub. Date - Int. Class - Applicant: - 28.01.2010 - A61K 36/35 - IZUN PHARMACEUTICALS, INC.
Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.


Title: METHOD FOR PREPARING POLYSACCHARIDE OF GREEN TEA AND COSMETIC COMPOSITION FOR SKIN WHITENING, MOISTURIZATION AND ANTI-WRINKLE EFFECTS COMPRISING THE POLYSACCHARIDE

Publication No: WO2010/011020
Pub. Date - Int. Class - Applicant: - 28.01.2010 - A61K 8/97 - AMOREPACIFIC CORPORATION

Disclosed is a method for preparing polysaccharides of green tea, and more particularly to a method for preparing polysaccharides of green tea comprising the steps of: a) removing chlorophyll and a low molecular weight polyphenol from green tea powder using a solvent; b) hot-water extracting a water-soluble active ingredient from the green tea residue of step a); and c) separating the polysaccharides of green tea from the hot-water extract of step b) by ultrafiltration and ethanol precipitation. Also, the present invention relates to a cosmetic composition for skin whitening, moisturization and anti-wrinkle effects comprising the polysaccharides of green tea as an effective ingredient.


Title: TREATING INFLAMMATION AND RELATED CONDITIONS WITH IRINDALONE

Publication No: WO2010/006231
Pub. Date - Int. Class - Applicant: - 14.01.2010 - A61K 31/496 - ORE PHARMACEUTICALS INC.
A method for treating an inflammatory condition or immune disorder comprises administering to a subject having such a condition or disorder a therapeutically effective amount of at least one compound selected from irindalone, physiologically active enantiomers thereof, and pharmaceutically acceptable salts thereof. The invention further provides a method for elevating levels of anti-inflammatory cytokines such as IL- 10 and IL- 13 while inhibiting expression of pro-inflammatory cytokines. A pharmaceutical composition, useful for example in topical treatment of psoriasis, comprises a therapeutically effective amount of at least one compound selected from irindalone, physiologically active enantiomers thereof, and pharmaceutically acceptable ...


Title: COMPOSITIONS FOR THE TREATMENT OF HAIR LOSS

Publication No: WO2010/004303
Pub. Date - Int. Class - Applicant: - 14.01.2010 - A61K 31/704 - BOURAS, Elias
A composition for the treatment or prevention of a disorder resulting in hair loss comprises a cardiac glycoside as active principal.


Title: ANHYDROUS ANTIPERSPIRANT COMPOSITION COMPRISING A VOLATILE LINEAR C9-C17 ALKANE; AEROSOL DEVICE

Publication No: WO2010/003814
Pub. Date - Int. Class - Applicant: - 14.01.2010 - A61K 8/04 - L'OREAL
The present invention relates to an antiperspirant composition, characterized in that it comprises, in a cosmetically acceptable anhydrous liquid vehicle: (a)at least one antiperspirant active principle; (b) at least one volatile linear C9-C17 alkane; (c)at least one propellant. The invention also relates to an aerosol device composed of: (A) a container comprising a composition composed, on the one hand, of an anhydrous liquid phase (or dispensable) comprising at least one antiperspirant active principle and at least one volatile linear C9-C17 alkane, and (B) at least one propellant and of a means for dispensing the said aerosol composition. The invention also relates to a method for the treatment of human perspiration and the human body o...


Title: TOPICAL COMPOSITION FOR THE TREATMENT OF ACTINIC KERATOSIS

Publication No: WO2010/003568
Pub. Date - Int. Class - Applicant: - 14.01.2010 - A61K 31/196 - ALMIRALL HERMAL GMBH
The invention relates to a topical gel composition comprising (a) an active agent for treatment of actinic keratosis, (b) a keratolytically active agent, (c) a gel former and (d) an organic solvent for use in the treatment of actinic keratosis.


Title: COMPOSITION FOR TOPICAL USE COMPRISING QUININE

Publication No: WO2010/000686
Pub. Date - Int. Class - Applicant: - 07.01.2010 - A61K 31/49 - VISENTINI, Federico
A composition comprising at least one active ingredient comprising quinoline-methanol (quinine) or a salt thereof for the dermal treatment of disorders or diseases or pain outcomes..
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WORLD PATENTS IN ACTIVES FOR SKIN CARE GRANTED IN  2010
This list includes patent documents published by the World Intellectual Property Organization (WIPO). The list was retrieved by searching the claims section of all patent applications
published. Salient search terms include skin care active ingredients having properties such as anti-ageing, anti-wrinkle, antioxidant, acne control benefits, skin whitening or lightening,
blemish removal, etc. This category includes technology related to the synthesis and delivery of actives such as peptides, exfoliants, α-hydroxy acids, herbals, free radical scavenger, "green"
derived molecules, etc.
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