PCT -  World Patents in Skin Care Actives Published in 2009

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PCT - WORLD PATENTS IN SKIN CARE ACTIVES PUBLISHED IN 2009


Title: PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER COMPRISING TRIAZINE COMPOUND AS AN ACTIVE INGREDIENT

Publication No: WO2009/157628
Pub. Date - Int. Class - Applicant: - 30.12.2009 - A61K 31/53 - INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
This invention relates to a pharmaceutical composition for anti-cancer. The present invention provides a pharmaceutical composition for anti-cancer comprising any one of triazine compounds represented by a formula I as an active ingredient. The triazine compound as an active ingredient of the pharmaceutical composition in the present invention has an inhibitory activity on cancer cell invasion or a specific cytotoxicity to cancer cells, enabling to be applied as an effective anti-cancer drug.


Title: PRODUCT AND COMPOSITION FOR ALLEVIATING POST-MENSTRUAL SYMPTOMS COMPRISING CARAPA PROCERA AND CALOTROPIS PROCERA

Publication No: WO2009/155497
Pub. Date - Int. Class - Applicant: - 23.12.2009 - A61P 29/00 - KENNEDY, Lina
The current invention relates to a natural composition for topical application to skin to alleviate post-menstrual symptoms of cramping, backache, and breast tenderness; and for other aches and pains including Rheumatic, muscular and articular pains; and local treatment such as tendinitises, tennis elbow, benign distorsions, arthritis, osteoarthritis, neuralgia, sciatic nerve, lumbago, back pains, migraine, stiff neck, and insect bites. In one embodiment, the composition of the cream or lotion includes active natural ingredients of Carapa procera and Calotropis procera with shea butter and soy- oil. In one emdodiment the composition includes,- by weight percent, 30% to 80% Butyrospermum parkii (Shea butter),- 10% to 30% Glycine soja (soy); ...


Title: ANTIVIRAL TERPENOID COMPOUNDS

Publication No: WO2009/153791
Pub. Date - Int. Class - Applicant: - 23.12.2009 - A61K 31/015 - AVIVI-EASY-LIFE LTD.
A composition for the treatment or prevention of viral infections, comprises as an active ingredient ? -terpinene or ? -terpinene or terpinene-4-ol, or a mixture of two or more of said compounds. Combinations of acyclovir with ?-terpinene, ?-terpinene, terpinen-4-ol or any combination thereof, pharmaceutical compositins comprising them and their use are also disclosed.


Title: COMPOSITION FOR TRANSDERMAL DELIVERY OF CATIONIC ACTIVE AGENTS

Publication No: WO2009/153019
Pub. Date - Int. Class - Applicant: - 23.12.2009 - A61K 9/70 - LTS LOHMANN THERAPIE-SYSTEME AG
The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof, said composition comprising said at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of said composition as a component of a transdermal patch or of an iontophoretic transdermal patch, and to the use of said composition in a method for transdermalIy or iontophoretically administering cationic active agents, and to a method for determining the in vitro skin permeation properties of an active agent containing iont...


Title: BICYCLIC HETEROARYL COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Publication No: WO2009/152087
Pub. Date - Int. Class - Applicant: - 17.12.2009 - C07D 487/04 - PLEXXIKON, INC.
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Raf protein kinases, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, cholangiocarcinoma, pain or polycystic kidney disease.


Title: TOPICAL ANTIMUSCARINIC FORMULATIONS

Publication No: WO2009/150408
Pub. Date - Int. Class - Applicant: - 17.12.2009 - A61K 9/00 - SUMMIT CORPORATION PLC
Topical compositions comprising muscarinic receptor antagonists and to methods of treating various skin disorders and diseases using the compositions are disclosed. In particular, the invention relates to compositions comprising muscarinic receptor antagonists for the treatment of acne, seborrhoea and for the reduction of excess sebum excretion. Preferred are hydrogel compositions comprising oxybutynin for topical application to the skin wherein the composition has a pH of 3.0 to 5.5 and compositions comprising a muscarinic receptor antagonist for topical application to the skin which yields a muscarinic receptor antagonist active plasma:dermis concentration ratio such that a non-spasmolytic concentration of muscarinic receptor antagonist a...


Title: DRUG DELIVERY COMPOSITION

Publication No: WO2009/147372
Pub. Date - Int. Class - Applicant: - 10.12.2009 - A61K 9/00 - THE QUEEN'S UNIVERSITY OF BELFAST
There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.


Title: COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Publication No: WO2009/143024
Pub. Date - Int. Class - Applicant: - 26.11.2009 - C07D 487/04 - PLEXXIKON, INC.
Compounds of Formula (I) which are active of Raf protein kinase and useful to treat melanoma, cancer, pain or polycystic kidney disease.


Title: COMPOSITIONS AND METHODS INCORPORATING PHOTOCATALYSTS

Publication No: WO2009/140076
Pub. Date - Int. Class - Applicant: - 19.11.2009 - A61K 8/34 - THE PROCTER &GAMBLE COMPANY
The various embodiments provide a composition including an active material having functional groups capable of covalent attachment to a substrate in the presence of an acid or a base, a photocatalyst capable of generating an acid or a base upon exposure to light, and a vehicle. The compositions may also include surfactants, emulsifiers, oxidants, and other components. A method for treating a substrate is also disclosed. The method includes the steps of applying at least one active material having functional groups to the substrate, applying a photocatalyst to the substrate, and exposing the photocatalyst and the at least one active material to light for forming covalent attachments between the functional groups and constituent groups on the...


Title: COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING MICROENCAPSULATED COLORANTS

Publication No: WO2009/138978
Pub. Date - Int. Class - Applicant: - 19.11.2009 - A61K 8/11 - TAGRA BIOTECHNOLOGIES LTD
Color-changing cosmetic or therapeutic compositions for topical application are provided, comprising one or more active substances and one or more microencapsulated colorants, which upon application on the skin provide a changing color effect that indicates the delivery of the active substances from said composition onto the skin and/or gives to the skin a visual esthetical effect.


Title: TOPICAL COMPOSITION OF OPIOID COMPOUND FOR USE IN WOUND HEALING

Publication No: WO2009/138737
Pub. Date - Int. Class - Applicant: - 19.11.2009 - A61K 9/00 - SERENTIS LIMITED
A composition which is a solid or semi-solid suitable for topical delivery of an active agent retained therein and available from the surface of the composition, wherein the active agent is buprenorphine or a pharmaceutically acceptable acid addition salt thereof.


Title: Alpha-lactalbumin composition for the treatment of actinic keratosis

Publication No: WO2009/135494
Pub. Date - Int. Class - Applicant: - 12.11.2009 - A61K 38/38 - NYA HAMLET PHARMA AB
The present invention relates to a pharmaceutical composition comprising monomeric alpha-lactalbumin complex, preferably LAC, which is an active complex of alpha- lactalbumin and a fatty acid or lipid with selective cytotoxic activity for the treatment of malignant and/or pre-malignant skin conditions, preferably actinic keratosis. The composition of the invention comprises insignificant amounts of oligomeric/multimeric alpha-lactalbumin complex, preferably LAC. Based on the selective cytotoxicity of the alpha-lactalbumin complex, preferably LAC composition such compositions are suitable for use in the manufacture of medicaments for use in therapy. Medicaments, comprising monomeric LAC are for use in the treatment of malignant and/or pre- m...


Title: PHARMACEUTICAL FORMULATION CONTAINING PALMITOYL ETHANOLAMIDE AND STEAROYL ETHANOLAMIDE

Publication No: WO2009/133574
Pub. Date - Int. Class - Applicant: - 05.11.2009 - A61K 9/06 - VERMONT ITALIA SRL
The invention concerns new pharmaceutical formulations containing a blend of palmitoyl ethanolamide or PEA and stearoyl ethanolamide or SEA compounds as active principles. The formulation is suitable for oral, parenteral, topical, transdermic, rectal, sublingual, nasal, topical, transdermic, rectal, nasal or sublingual administration, whereby the dosage form of said formulations can be in patches, suppositories, ovules, pessaries, aerosol or spray, emulsions, suspensions, solutions. Said pharmaceutical formulations are useful for the treatment or prevention of skin pathologies, for the treatment or prevention of gynaecological pathologies, for the treatment of disorders or pathologies characterised by improper metabolism of fatty acids as w...


Title: A NOVEL ANTI-AGING SKINCARE CREAM, THE COSMETIC DEVICE AND CREAM WITHIN

Publication No: WO2009/132585
Pub. Date - Int. Class - Applicant: - 05.11.2009 - C07K 5/097 - YOLARE DERMACEUTICALS, LLC.
This invention reveals a novel skin-rejuvenating method that combines the application of light physics (a Light emitting diode (LED) device with specific wavelength, intensity, and pulsing frequency) and biochemistry (a specific collagenase inhibitor). The programmed LED light can penetrate skin epidermis and activate the fibroblasts in dermis to produce new collagen. Meanwhile, the overproduction of collagen leads to the feedback activation of collagenase, which degrades collagen and eliminates the beneficiary effects of LED light. Hence, this invention also includes a topical cream containing a certain lipophilic collagenase inhibitor, which, when used alone or in combination with the light device, can maintain high levels of skin collage...


Title: ACTIVE SUNSCREEN COMPOSITION

Publication No: WO2009/132352
Pub. Date - Int. Class - Applicant: - 29.10.2009 - A61Q 17/04 - RHODE ISLAND HOSPITAL
The invention relates to topical compositions comprising a fluorescent dye that absorbs UVA and UVB radiation and converts it into a healing light, in combination with a dermatologically acceptable excipient. The compositions of the invention are useful for repairing photo-damaged skin cells and reducing or preventing future skin damage as a result of exposure to UV light.


Title: SUBSTITUTED PHENOXYBENZAMIDES

Publication No: WO2009/129938
Pub. Date - Int. Class - Applicant: - 29.10.2009 - C07C 217/92 - BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
The present invention relates to substituted phenoxybenzamide compounds of general formula (I) : in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.


Title: SKIN CARE COMPOSITIONS AND METHODS OF USE THEREOF

Publication No: WO2009/127058
Pub. Date - Int. Class - Applicant: - 22.10.2009 - A61K 8/30 - IMMANENCE INTEGRALE DERMO CORRECTION INC.
A topical composition comprising at least 10 isolated active agents which each have at least one activity selected from the group consisting of anti-oxidant activity, anti-matrix metalloproteinase (MPP) activity, anti-elastase activity, anti-inflammation activity, anti-irritation activity, microcirculation support activity, collagen synthesis activity, energy production activity, oxygenation activity, DNA protection and repair activity, cell anchorage suppport activity, dermal-epidermal cohesion support activity, cellular renewal activity, synthesis and/or protection of glycosaminoglycans activity, prevention and/or repair and/or elimination of damaged proteins activity, protection of skin immune function activity, hydration activity, modul...


Title: CONTROLLED RELEASE OF ACTIVE AGENTS FROM OLEOSOMES

Publication No: WO2009/126301
Pub. Date - Int. Class - Applicant: - 15.10.2009 - A61K 47/10 - SEMBIOSYS GENETICS, INC.
The release rate of an active agent from oleosomes can be modulated by formulation of the oleosomes with a release control agent, such as a multihydric alcohol. In this context, oleosomes containing an active agent may be used in the preparation of a variety of formulations, including formulations for topical use.


Title: ACTIVE INGREDIENT THAT STIMULATES THE PROLIFERATION AND/OR ACTIVITY OF FIBROBLASTS

Publication No: WO2009/121422
Pub. Date - Int. Class - Applicant: - 08.10.2009 - A61K 8/97 - BASF BEAUTY CARE SOLUTIONS FRANCE SAS
The invention relates to a novel active ingredient that stimulates the proliferation and/or the activity of fibroblasts and also to its applications in the cosmetic or pharmaceutical, in particular dermatological, field. In particular, the active ingredient according to the invention comprises a combination of at least one Hibiscus Abelmoschus extract and a soy extract containing at least peptides.


Title: 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Publication No: WO2009/118411
Pub. Date - Int. Class - Applicant: - 01.10.2009 - C07D 405/12 - NERVIANO MEDICAL SCIENCES S.r.l.
Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof,their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment ofdiseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.


Title: FOOD PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING AN EMBRYONIC EXTRACT

Publication No: WO2009/115429
Pub. Date - Int. Class - Applicant: - 24.09.2009 - A61K 35/54 - CUNILL AIXELA, Joan
The invention relates to a food preparation and pharmaceutical composition containing an embryonic extract and their respective uses. The food preparation comprises an embryonic germ in the final gastrula phase extracted from a fertilized and incubated egg. In addition, the pharmaceutical composition contains as an active substance an embryonic extract in the final gastrula embryonic development stage extracted from a fertilized and incubated egg. Said preparation is used as a food supplement for the prevention of hair loss. In addition, said pharmaceutical composition can be used as a medicament for antidegenerative treatments.


Title: METHOD FOR ENHANCING DISPERSION OF INORGANIC COMPOUNDS USING SILICONE-CONTAINING ESTERS AND COMPOSITIONS FORMED THEREFROM

Publication No: WO2009/114210
Pub. Date - Int. Class - Applicant: - 17.09.2009 - A61K 8/31 - EXXONMOBIL CHEMICAL PATENTS INC.
A cosmetic composition comprising: (a) an aqueous phase comprising: (i) water, and (ii) at least one cosmetically active ingredient; (b) a coupling agent; and (c) an oil phase comprising: (i) an isoparaffin solvent, and (ii) a silicone-containing solvent having the formula:


Title: ANTI-AGING COMPOSITION FOR EXTERNAL USE COMPRISING LOW AND HIGH MOLECULAR WEIGHT HYALURONIC ACIDS AND THE POLYSACCHARIDES EXTRACTED FROM ROOT BARK OF ULMUS DAVIDIANA

Publication No: WO2009/113820
Pub. Date - Int. Class - Applicant: - 17.09.2009 - A61Q 19/08 - BIOLAND LTD.
Disclosed is an anti-aging composition for external use on skin, which includes low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients. The composition including the low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, in a predetermined ratio, shows significantly improved skin-moisturizing, skin elasticity-enhancing and inflammation-alleviating effects, as compared to a composition using one of the above ingredients alone. Therefore, the composition may be widely used as a pharmaceutical or cosmetic anti-aging composition.


Title: ACTIVE SUBSTANCES THAT INCREASE THE ACTIVATION THRESHOLD OF IMMUNE CELLS

Publication No: WO2009/112590
Pub. Date - Int. Class - Applicant: - 17.09.2009 - A61Q 19/00 - BASF BEAUTY CARE SOLUTIONS FRANCE SAS
The present invention relates to the use of active substances that increase the activation threshold of immune cells as an active principle for the preparation of a cosmetic or pharmaceutical composition, especially a dermatological composition. The invention also relates to a method for screening such active substances.


Title: METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND

Publication No: WO2009/111695
Pub. Date - Int. Class - Applicant: - 11.09.2009 - A61K 31/59 - WISCONSIN ALUMNI RESEARCH FOUNDATION
Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-19-nor-20(S)-1?-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1?,25-dihydroxyvitamin D3, 2-methylene-19-nor-(24R)-1?,25-dihydroxyvitamin D2, 2-methylene-1?,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1?,25-dihydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1?,25-dihydroxyvitamin D3, 2-methylene-19-nor-1?-hydroxy-pregnacalciferol, 1?-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R...


Title: ALL-TRANS RETINOID ESTERS AS ACTIVE PHARMACEUTICAL INGREDIENTS, ORAL AND TOPICAL DOSAGE FORM COMPOSITIONS THEREOF, AND METHODS OF TREATING SKIN CONDITIONS THEREOF

Publication No: WO2009/111688
Pub. Date - Int. Class - Applicant: - 11.09.2009 - A01N 37/00 - WISCONSIN ALUMNI RESEARCH FOUNDATION
Active pharmaceutical ingredients being retinoic acid ester compounds including all- trans-retinoic acid tert-butyl ester, all-trans-retinoic acid iso-butyl ester, all-trans-retinoic acid iso-propyl ester, all-trans-retinoic acid sec-butyl ester, and, all-trans-retinoic acid 1-adamantyl ester, oral and topical dosage form compositions thereof, and methods of treating various skin conditions thereof.


Title: TOPICAL FORMULATIONS FOR THE PREVENTION OF SEXUALLY TRANSMITTED DISEASE AND METHODS OF PRODUCING THE SAME

Publication No: WO2009/108210
Pub. Date - Int. Class - Applicant: - 03.09.2009 - A61K 8/02 - CLJI CORPORATION
The present invention is directed towards various topical protective formulations which may be used as an adjunct in preventing the spread of a broad range of sexually transmitted diseases. The product is intended to be used as a topical lotion, cream, emulsion, or the like. The film forming excipients and active ingredients in the following formulations have demonstrated unique skin protective barrier properties with enhanced persistence that inhibits transmission of sexually transmitted diseases.


Title: AGENT FOR PREVENTING OR AMELIORATING SKIN AGING

Publication No: WO2009/107853
Pub. Date - Int. Class - Applicant: - 03.09.2009 - C07H 15/256 - KAO CORPORATION
An agent for preventing or ameliorating skin aging, which exhibits a more excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin. An agent for preventing or ameliorating skin aging, containing triterpenoid saponins represented by the following formula (1) as an active ingredient, wherein at least one of R1 and R2 is a tigloyl group and the other represents a tigloyl group or an angeloyl group; R3 represents a methyl group or a hydroxymethyl group; and R4 represents Glc, Xyl or Gal.


Title: ACTIVE INGREDIENT COMBINATION AND USE THEREOF

Publication No: WO2009/106468
Pub. Date - Int. Class - Applicant: - 03.09.2009 - A61K 8/34 - AIR LIQUIDE SANTE (INTERNATIONAL)
The invention relates to an active ingredient combination which comprises a) glycerol monoalkyl ether, b) bispyridinium alkane, c) polyol and d) antioxidant. The combination is advantageously used for producing a preparation for the treatment of undesired body odour, for example for producing a cosmetic deodorant preparation, an antidandruff hair cleansing composition, a preparation for the treatment of blemished skin and acne or a preparation for the treatment of foot and/or skin fungus.


Title: TOPICAL COMPOSITIONS AND METHODS FOR WHITENING SKIN

Publication No: WO2009/105294
Pub. Date - Int. Class - Applicant: - 27.08.2009 - A61K 8/14 - ELC MANAGEMENT LLC
Methods and compositions for whitening or brightening skin comprising at least one whitening active contained in association structures.


Title: SKIN PENETRATION ENHANCING SYSTEMS FOR POLAR DRUGS

Publication No: WO2009/103069
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61K 9/00 - OSBORNE, David, W.
The invention relates to pharmaceutical compositions and related methods for the topical administration of polar drugs. In a particular embodiment, the invention relates to a pharmaceutical composition comprising an active pharmaceutical agent that is a polar drug, such as potassium 2,5-dihydroxybenzenesulfonate, at least one occlusive agent, and at least one stabilizer.


Title: TOPICAL PHARMACEUTICAL COMPOSITION

Publication No: WO2009/101412
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61K 9/00 - CIPLA LIMITED
A transdermal pharmaceutical composition for spraying comprising: a. pharmaceutically active agent, b. at least one penetration enhancing agents, comprising a phospholipid, a lipid or a combination thereof, c. film forming polymer, such as a copolymer of polyvinyl alcohol and polyvinylpyrrolidone d.vehicle e. optionally, a propellant and/or other pharmaceutically acceptable excipients and a volatile silicone as emollient.


Title: METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT INHIBITING THE GROWTH OF MICRO-ORGANISMS AND FOR MAXIMIZING THE EFFECT

Publication No: WO2009/101262
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A01N 65/00 - OY GRANULA AB LTD
The invention relates to a mixture to be included in a composition or its semi-finished product, which composition or its semi-finished product contains at least one anti-micro-organistic agent; a possible solvent system with either hydrophobic or hydrophilic nature, selected according to the target of usage; as well as possible surface active agent. The mixture is obtained by pulverizing wood or plant material and/or by extracting the possibly pulverized wood or plant material, so that said mixture contains at least two different polyphenolic compounds selected from the following group: lignans, stilbenes, juvabiones and flavonoids; said mixture further containing oligomers of said polyphenolic compounds, so that the mixture also must have...


Title: METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT IN A COMPOSITION THAT IS ADMINISTERED TO A MAMMAL OR GETS INTO CONTACT WITH A MAMMAL

Publication No: WO2009/101261
Pub. Date - Int. Class - Applicant: - 20.08.2009 - A61K 8/49 - OY GRANULA AB LTD
The invention relates to a mixture to be included in a composition or its semifinished product that is administered to a mammal or gets into contact with a mammal, said composition or its semifinished product containing at least one first effective agent; as well as a possible solvent system with either hydrophobic or hydrophilic nature, selected according to the target of usage; and a possible surface active agent. The mixture is obtained by pulverizing wood or plant material and/or by extracting the possibly pulverized wood or plant material, so that said mixture contains at least two different polyphenolic compounds, selected from among the group: lignans, stilbenes, juvabiones and flavonoids, said mixture also containing oligomers of sa...


Title: METHODS AND COMPOSITIONS USING KLOTHO-FGF FUSION POLYPEPTIDES

Publication No: WO2009/095372
Pub. Date - Int. Class - Applicant: - 06.08.2009 - C07K 14/50 - NOVARTIS AG
The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. The Klotho fusion proteins are useful in the treatment and preventionofa variety of age-related conditions and metabolic disorders.


Title: COSMETIC COMPOSITION COMPRISING GLYCOGEN FOR SKIN APPLICATION WITH VELVET EFFECT

Publication No: WO2009/095341
Pub. Date - Int. Class - Applicant: - 06.08.2009 - A61K 8/73 - AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
This invention relates to a cosmetic composition for skin application having a velvet effect on the skin comprising, as the cosmetic active ingredient, a glycogen having less than 1,000 ppm of nitrogen and less than 1 % by weight of reducing sugars, in at least one cosmetically- acceptable vehicle.


Title: NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS

Publication No: WO2009/095226
Pub. Date - Int. Class - Applicant: - 06.08.2009 - C12N 15/09 - CUREVAC GMBH
The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to ...


Title: METHODS AND COMPOSITIONS FOR TOPICAL TREATMENT OF MEDICAL CONDITIONS INCLUDING WOUNDS AND INFLAMMATION

Publication No: WO2009/094473
Pub. Date - Int. Class - Applicant: - 30.07.2009 - A61K 31/203 - BIOCHEMICS, INC.
A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.


Title: 13.13-DIMETHYL-DES-C,D ANALOGS OF 1ALPHA, 25-DIHYDROXY-19-NOR-VITAMIN D3 COMPOUNDS AND TOPICAL COMPOSITION DOSAGE FORMS AND METHODS OF TREATING SKIN CONDITIONS

Publication No: WO2009/094426
Pub. Date - Int. Class - Applicant: - 30.07.2009 - C07C 35/17 - WISCONSIN ALUMNI REASEARCH FOUNDATION
13,13-Dimethyl-flfes-C,D analogs of lα,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (lR,3R)-5-[(E)-(S)-11'-hydroxy- 5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-diol, (lR,3R)-5-[(Z)-(S)-11 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-diol, (lR,3R)-5-[(E)-(R)-l 1 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene- cyclohexane-l,3-diol, and (lR,3R)-5-[(Z)-(R)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'- enylidene] -2-metylene-cyclohexane- 1,3 -diol.


Title: ANTI-GLYCATION HYDROLYSATE OF G. LUCIDUM

Publication No: WO2009/091842
Pub. Date - Int. Class - Applicant: - 23.07.2009 - A61K 8/99 - ACTIVE ORGANICS, LP
Methods and compositions for reducing the levels of Advanced Glycation Endproducts (AGE) related proteins in the skin by topical application of dermatocosmetic compositions comprising effective amounts of extracts of Ganoderma lucidum that have been hydrolyzed by an acid protease, preferably Rhizomucor miehei, and thereafter rendered substantially devoid of acid-protease activity.


Title: METHOD FOR EXTRACTING USING GLACIAL WATER AND THE EXTRACT THEREOF, AND COSMETIC COMPOSITION COMPRISING NAMOEMULSION PARTICLES HAVING THE EXTRACT ENCAPSULATED OR THE GLACIAL WATER.

Publication No: WO2009/091183
Pub. Date - Int. Class - Applicant: - 23.07.2009 - A61K 8/19 - AMOREPACIFIC CORPORATION
The present invention relates to a method for extracting an active ingredient by using glacier water, accumulated for a long period of time, as an extraction solvent, an extract thereof, and a cosmetic composition comprising nanoemulsion particles having the extract encapsulated by the nanoemulsion technology to improve transdermal permeation, in which the extracts contain various minerals or active ingredients. Also, the present invention relates to a cosmetic composition comprising glacier water as an active ingredient to supply moisture to the skin, to reduce loose keratin and to soften the skin texture.


Title: POLOXAMER FOAMABLE PHARMACEUTICAL COMPOSITIONS WITH ACTIVE AGENTS AND/OR THERAPEUTIC CELLS AND USES

Publication No: WO2009/090558
Pub. Date - Int. Class - Applicant: - 23.07.2009 - A61K 9/00 - FOAMIX LTD.
Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1 % to about 15% by weight; wherein when the Poloxamer is between about 0.1 % to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.


Title: OIL AND LIQUID SILICONE FOAMABLE CARRIERS AND FORMULATIONS

Publication No: WO2009/090495
Pub. Date - Int. Class - Applicant: - 23.07.2009 - A61K 9/12 - FOAMIX LTD.
A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01 % to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for us...


Title: COMPOSITION FOR SKIN WHITENING CONTAINING DIOSGENIN

Publication No: WO2009/088109
Pub. Date - Int. Class - Applicant: - 16.07.2009 - A61K 8/63 - BIOSPECTRUM, INC.
The present invention relates to a skin-whitening composition, characterized by comprising diosgenin as an active ingredient. The composition comprising diosgenin can be safely used without side effects, and suppress melanin synthesis to inhibit pigmentation, thereby being used for improving melasma or freckles, and whitening skin.


Title: TOPICAL COMPOSITIONS FOR THE CONTROLLED DELIVERY OF PROTEINS AND PEPTIDES

Publication No: WO2009/087485
Pub. Date - Int. Class - Applicant: - 16.07.2009 - A61K 9/19 - KRINGLE PHARMA INC.
Aspects of this invention relate to compositions and methods for the stabilization, storage, and delivery of biologically active agents, in particular peptides and nucleic acids. Particularly preferred embodiments include compositions that comprise a recombinant naturally occurring human hepatocyte growth factor (HGF), such as dHGF, a five amino acid truncated HGF variant, and at least one monoglyceride that remains in crystalline form at body temperature. Optionally, a gelling agent such as, hydroxyethylcellulose, and/or an antipathogenic compound (e.g., bupivacaine) can be included in the composition. Methods of use of these compositions to improve, ameliorate, or treat skin conditions are also embodiments.


Title: SKINCARE TREATMENT

Publication No: WO2009/087354
Pub. Date - Int. Class - Applicant: - 16.07.2009 - A61K 31/60 - RECKITT BENCKISER (UK) LIMITED
The invention relates to a method of treating acne by the topical administration of an acne active ingredient in the presence of a) an anhydrous composition comprising a component that in the presence of water generates heat, and b) water. The invention also relates to an acne treatment kit comprising a first composition which is anhydrous and comprises a component that in the presence of water generates heat on the skin to which it is applied and a second composition which comprises an aqueous carrier, at least one of said compositions comprising an acne active ingredient, said compositions being stored in isolation from each other and being capable of generating heat when they are combined.


Title: BIOCOMPATIBLE PROTEIN PARTICLES, PARTICLE DEVICES AND METHODS THEREOF

Publication No: WO2009/086483
Pub. Date - Int. Class - Applicant: - 09.07.2009 - A61K 9/14 - GEL-DEL TECHNOLOGIES, INC.
The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein- based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder...) and organ(s) (e.g. bladder, lips, vagina, penis, urethra...). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.


Title: PERSONAL CARE COMPOSITIONS CONTAINING SKIN CONDITIONING AGENTS

Publication No: WO2009/083895
Pub. Date - Int. Class - Applicant: - 09.07.2009 - A61K 8/04 - THE PROCTER &GAMBLE COMPANY
Personal care compositions are provided that include an aqueous base composition and a volatile post foaming agent mixed with the base composition. The base composition comprises a lipophilic skin conditioning agent, a structuring agent, and a water soluble or water dispersible surface active agent. The personal care composition is used as skin shaving, cleansing and moisturizing agent.


Title: HIGH OIL CONTENT O/W EMULSIONS STABILIZED WITH A HYDROPHOBICALLY MODIFIED INULIN AND A HYDROPHILIC ACRYLIC POLYMER

Publication No: WO2009/080661
Pub. Date - Int. Class - Applicant: - 02.07.2009 - A61K 8/06 - L'OREAL
The invention relates to a composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium: i) at least 0.005% by weight, preferably at least 0.01% by weight, relative to the total weight of the composition, of at least one inulin modified with hydrophobic chains, and ii) at least 0.01% by weight, preferably at least 0.05% by weight, of active substance relative to the total weight of the composition, of at least one hydrophilic acrylic polymer selected from the at least partially neutralized, crosslinked acrylic homopolymers or copolymers, the polyacrylamidomethyl-propanesulphonic acid (AMPS) homopolymers and mixtures thereof. It also relates to a cosmetic method employing said composition.


Title: FABRIC TREATMENT ACTIVE

Publication No: WO2009/080570
Pub. Date - Int. Class - Applicant: - 02.07.2009 - C11D 1/62 - UNILEVER PLC
Use of an HH material in a fabric softener composition, comprising a fabric softening compound, to increase comfort of fabric, wherein the HH material is capable of changing its hydrophobic/hydrophilic properties in response to an activation step, and wherein the HH material is a terpene having the general formula:- (C5H8)n where n is from 3 to 8.


Title: ANTI-DANDRUFF COMPOSITIONS CONTAINING PEPTIDES

Publication No: WO2009/080306
Pub. Date - Int. Class - Applicant: - 02.07.2009 - A61K 8/64 - BASF SE
The present invention relates to the use of special peptides in compositions which can be used in particular in hair and skin cosmetics, and to such peptide-containing compositions. In particular, the present invention relates to the use of such peptides as active ingredient for inhibition or treatment of dandruff which does not accumulate in the body or in the environment. Furthermore, the invention relates to the production of such compositions, to the peptides used themselves, to their production and to coding nucleotide sequences for such peptides, to dispensing systems for such peptides and to screening methods for identifying suitable further peptides.


Title: COMPOSITION OF THE SKIN EXTERNAL APPLICATION OR THE FOOD FOR ACCELERATING PROLINE RECYCLING BY CONTAINING THEANINE

Publication No: WO2009/078597
Pub. Date - Int. Class - Applicant: - 25.06.2009 - A61K 8/44 - AMOREPACIFIC CORPORATION
Disclosed herein is a composition for promoting proline recycling, and more particularly, to a composition for external application to skin or cosmetic food comprising theanine as an active ingredient for promoting expression or activity of prolidase, which is an enzyme to promote proline recycling, thereby increasing collagen synthesis and restoring wrinkle.


Title: SOLID ANTIPERSPIRANT AND/OR DEODORANT COMPOSITION IN THE FORM OF A WATER-IN-OIL EMULSION BASED ON SILICONE EMULSIFIERS AND ON WAXES; METHOD FOR TREATING BODY ODOURS

Publication No: WO2009/077453
Pub. Date - Int. Class - Applicant: - 25.06.2009 - A61K 8/06 - L'OREAL
The invention relates to a solid composition in the form of a water-in-oil emulsion comprising, in a cosmetically acceptable carrier: (i) at least one discontinuous aqueous phase, (ii) at least one fatty phase comprising at least one particular wax, (iii) at least one silicone emulsifier selected in the group consisting in alkyldimethicone copolyols of particular formula (I) and dimethicone copolyols of particular formula (II) and mixtures there of (iv) and at least one antiperspirant active agent and/or one deodorant active agent. The invention relates to a method for treating body odours associated with human perspiration, and in particular body odours which are especially underarm odours. The invention relates to a method for preparing a...


Title: PHARMACEUTICAL FOAMS

Publication No: WO2009/074239
Pub. Date - Int. Class - Applicant: - 18.06.2009 - A61K 9/12 - MONTERESEARCH-PHARMACEUTICAL DEVELOPMENT SERVICE
Foams for the topical application of pharmaceutical active ingredients are based on a surfactant combination of non-hydrogenated lecithin and glycerides or their derivatives, the use of the surfactant combination results in improved absorption of the active ingredient by the skin.


Title: COMPOSITION FOR INHIBITION OF TRASPLANT REJECTION CONTAINING THE CORDYCEPS MYCELLIA EXTRACT AS AN ACTIVE INGREDIENT

Publication No: WO2009/072688
Pub. Date - Int. Class - Applicant: - 11.06.2009 - A61K 36/068 - HANKOOK PHARM. CO., INC.
Disclosed is a composition for the inhibition of transplant rejection and the prevention and treatment of skin diseases, comprising a cordyceps mycellia extract as an active ingredient. The cordyceps mycellia extract significantly suppresses the production of antibodies to transplants without side effects, such as weight change. Based on natural material, the composition is non-toxic and harmless to the human body and thus can be used as an immunosuppressant for organ transplantation. Also, it stops oozing from sores and is useful in the prevention and treatment of skin diseases, including atopy, allergic reactions, decubitus ulcers, pemphigus and smallpox.


Title: COMPOSITION FOR INHIBITION OF TRASPLANT REJECTION CONTAINING THE PHELLINUS LINTEUS MYCELLIA EXTRACT AS AN ACTIVE INGREDIENT

Publication No: WO2009/072687
Pub. Date - Int. Class - Applicant: - 11.06.2009 - A61K 36/07 - HANKOOK PHARM. CO., INC.
Disclosed is a composition for the inhibition of transplant rejection and the prevention and treatment of skin diseases, comprising a Phellinus sp. mycelial extract as an active ingredient. The Phellinus sp. mycelial extract significantly suppresses the production of antibodies to transplants without side effects, such as weight change. Based on natural material, the composition is non-toxic and harmless to the human body and thus can be used as an immunosuppressant for organ transplantation. Also, it stops oozing from sores and is applicable to the prevention and treatment of skin diseases, including atopy, allergic reactions, decubitus ulcers, and smallpox.


Title: CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF

Publication No: WO2009/072007
Pub. Date - Int. Class - Applicant: - 11.06.2009 - A61K 9/12 - FOAMIX LTD.
The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.


Title: COMPOSITION FOR SKIN EXTERNAL APPLICATION CONTAINING COMPLEX OF HERBAL EXTRACTS

Publication No: WO2009/069906
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A61K 8/97 - AMOREPACIFIC CORPORATION
Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacryma-jobi, Saururus chinensis and Perilla frutescens var. acuta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing...


Title: A COSMETIC COMPOSITION FOR SKIN WHITENING COMPRISING THE EXTRACT OF MAGNOLIA SIEBOLDII AS ACTIVE INGREDIENT

Publication No: WO2009/069839
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A61K 8/97 - COREANA COSMETICS, CO., LTD
Disclosed herein is a skin-whitening cosmetic composition comprising an extract of Magnolia sieboldii as an active ingredient. The Magnolia sieboldii extract has an excellent effect of inhibiting tyrosinase activity and melanin production, and the cosmetic composition comprising the Magnolia sieboldii extract as an active ingredient has an excellent skin-whitening effect.


Title: COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES

Publication No: WO2009/069022
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A01N 1/02 - MEDEVICE S.P.A.
The invention is based on the finding that calcium ions and proteolytic enzymes, particularly papain, act in a synergetic way in the regeneration of skin and connective tissues. Thus, such a combination of active principles can be used for the preparation of culture media for cutaneous and/or connective tissue biopsies, which allow for the maintenance of the biopsies under viable conditions for periods of over 6 months, even for over 3 years, as well as for the preparation of pharmaceutical compositions or medical devices for the treatment of diseases in which the regeneration of cutaneous and connective tissues is beneficial (for instance, injuries and wounds, keloids, paradontopathies, conjunctivitis, nasal and ear polyps, cellulite, huma...


Title: PERSONAL CARE AND COSMETIC COMPOSITION CONTAINING TETRAPEPTIDES WITH THE MOTIFS GX1X2G, PX1X2P, OR PX1X2K

Publication No: WO2009/068351
Pub. Date - Int. Class - Applicant: - 04.06.2009 - A61K 8/64 - EVONIK GOLDSCHMIDT GMBH
The present invention relates to topical personal care and skin care compositions comprising: a) a safe and effective amount of a tetrapeptide selected from the group of tetrapeptides with the motif GX1X2G, PX1X2P, or PX1X2K, derivatives thereof, and mixtures thereof; b) a safe and effective amount of at least one additional active ingredient selected from the group consisting of hydroxy acids, radical scavengers, UV absorbers, vitamins, anti-aging actives, barrier lipids, desquamatory actives, retinoids, anti-acne actives, tanning actives, anti-cellulite actives, anti-...


Title: TOPICAL COMPOSITION FOR TREATING PAIN

Publication No: WO2009/067535
Pub. Date - Int. Class - Applicant: - 28.05.2009 - A61K 31/77 - XVASIVE, INC.
Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands...


Title: COMPOSITION FOR THE TREATMENT OF HYPERTROPHIC SCARS COMPRISING FUCOSE, DIMETHYLSULFONE AND/OR ACETYL GLUCOSAMINE

Publication No: WO2009/063522
Pub. Date - Int. Class - Applicant: - 22.05.2009 - A61K 31/10 - de PAOLI AMBROSI, Gianfranco
This invention concerns a composition for pharmaceutical and/or cosmetic and/or in the form of medical device, in particular for the prevention and treatment of hypertrophic scars and/or cheloids, to inhibit any fibrosclerotic process and to improve the biomechanical properties of the skin and to obstruct retraction to cicatrisation of the skin, as it contains, as an active ingredient, at least one of the active principles chosen between fucose (and/or Fucose rich polysaccharides - FROPs), Dimethyl sulfone and acetyl glucosamine.


Title: A LONG-ACTING, WATERPROOF OR WATER-RESISTANT, TOPICAL SUN PROTECTION AGENT WITH ACTIVITY UP TO WEEKS

Publication No: WO2009/059064
Pub. Date - Int. Class - Applicant: - 07.05.2009 - A61K 8/81 - SPHJK, INC.
Disclosed herein are compositions for use as a sunscreen or sunblock which, in some embodiments, may provide long-acting, waterproof or water-resistant, broad spectrum topical sun protection with activity up to weeks without reappli cation. In some embodiments, the compositions may include a base and one or more active ingredients. In some embodiments, the base may include an adhesive component, which upon application to a user's skin, adheres the base to the user's skin. In some embodiments, the adhesive component is adapted to hold the active ingredients on the user's skin for at least about 8 hours, such as at least about 24 hours, such as at least about 3 days, or even at least about 2 weeks. Furthermore, in some embodiments, the compos...


Title: USE OF MELANIN BIOSYNTHESIS INHIBITORS FROM KOREAN GINSENG AND THE COSMETIC COMPOSITION CONTAINING THEREOF FOR SKIN WHITENING

Publication No: WO2009/057836
Pub. Date - Int. Class - Applicant: - 07.05.2009 - A61K 8/60 - AMOREPACIFIC CORPORATION
Disclosed herein is a whitening cosmetic composition containing plant-derived ginsenoside Fl (20-O-?-D- glucopyranosyl-20 (S) -protopanaxatriol) as an active ingredient. More specifically, the ginsenoside Fl is obtained from particularly a ginseng extract using an acid, a base, an enzyme or microorganism, and a whitening cosmetic composition containing the ginsenoside Fl has an excellent effect of inhibiting melanin biosynthesis, and thus provides an excellent skin whitening effect.


Title: TOPICAL COMPOSITION

Publication No: WO2009/056522
Pub. Date - Int. Class - Applicant: - 07.05.2009 - A61K 9/06 - NOVARTIS AG
The invention relates to beneficial topical pharmaceutical compositions comprising the diclofenac diethylammonium salt in unusually high amounts. Said compositions represent opaque emulsion-gels with unique properties such as high skin penetration, no irritation, high stability, complete dissolution of the active and high pain relief.


Title: A COMPOSITION COMPRISING ORTILIA SECUNDA EXTRACT AS AN ACTIVE INGREDIENT

Publication No: WO2009/054701
Pub. Date - Int. Class - Applicant: - 30.04.2009 - A61K 36/185 - KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
The present invention relates to a composition containing Ortilia secunda extract as an active ingredient. Ortilia secunda extract of the present invention extracted by using water, alcohol or a mixture thereof as a solvent inhibits the activity of AP-I (activator protein-1), a MMP-I transcription factor, inhibits type I collagenase, a skin matrix decomposing enzyme, but increases collagen, a major component of skin, so that it can be effectively used as a preparation for skin external application including cosmetics owing to its wrinkle and elasticity improving effects. In addition, Ortilia secunda extract of the present invention has radial scavenging effect, so that it can also be effectively used as an antioxidative agent.


Title: A COMPOSITION COMPRISING CHAMAENERION ANGUSTIFOLIUM EXTRACT AS AN ACTIVE INGREDIENT

Publication No: WO2009/054607
Pub. Date - Int. Class - Applicant: - 30.04.2009 - A61K 36/185 - KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
The present invention relates to a composition containing Chamaenerion angustifolium extract as an active ingredient. The Chamaenerion angustifolium extract of the present invention extracted by using water, alcohol or a mixture thereof as a solvent inhibits the transcription factor AP-1 (activator protein-1) activity, inhibits type I collagenase, the skin matrix decomposing enzyme, but increases collagen, one of the major components of skin, indicating that it has the effect of improving wrinkles and elasticity. Therefore, the Chamaenerion angustifolium extract of the present invention can be effectively used as a pharmaceutical composition, health food, a preparation for skin external application or cosmetics for the prevention of skin ag...


Title: A COMPOSITION COMPRISING PENTAPHYLLOIDES FRUTICOSA EXTRACT AS AN ACTIVE INGREDIENT

Publication No: WO2009/054606
Pub. Date - Int. Class - Applicant: - 30.04.2009 - A61K 36/73 - KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
The present invention relates to a composition containing Pentaphylloides fruticosa extract as an active ingredient. Pentaphylloides fruticosa extract of the present invention extracted by using water, alcohol or a mixture thereof as a solvent inhibits the activity of AP-1 (activator protein-1), a MMP-I transcription factor, inhibits type I collagenase, a skin matrix decomposing enzyme, but increases collagen, a major component of skin, so that it can be effectively used as a preparation for skin external application including cosmetics owing to its wrinkle and elasticity improving effects. In addition, Pentaphylloides fruticosa extract of the present invention...


Title: MULTI-FUNCTIONAL, MULTI-PHASE SKIN CARE PRODUCT

Publication No: WO2009/053898
Pub. Date - Int. Class - Applicant: - 30.04.2009 - A61K 8/03 - THE PROCTER &GAMBLE COMPANY
A skin care product may comprise a non-solid, multi-phase multi-function skin care composition comprising a translucent base phase, a first opaque phase, and a second opaque phase. The three phases form a stable, visually distinct pattern within a container that is at least partially translucent. The first opaque phase may have a lightness of greater than about 80 and a chroma of less than about 5. The second opaque phase may have a hue from about 35 to about 70. The translucent base phase may include a first chronic skin care active; the first opaque phase may include a skin conditioning agent; and the second opaque may comprise one or more opacifying particulate materials. The skin care product may further comprise a plurality of informat...


Title: IMPROVED TOPICAL PAIN RELIEF PRODUCT

Publication No: WO2009/049190
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61K 8/02 - MCNEIL-PPC, INC.
The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that povides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.


Title: ANTICANCER COMPOSITION COMPRISING PLANT STEM CELL LINE DERIVED FROM TAXUS CAMBIUM OR PROCAMBIUM

Publication No: WO2009/048306
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61K 38/56 - UNHWA BIOTECH. CORP.
The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.


Title: HIGH DOSE SOLID UNIT ORAL PHARMACEUTICAL DOSAGE FORM OF MYCOPHENOLATE SODIUM AND PROCESS FOR MAKING SAME

Publication No: WO2009/047799
Pub. Date - Int. Class - Applicant: - 16.04.2009 - A61K 31/343 - PANACEA BIOTEC LIMITED
Provided are high dose solid unit oral pharmaceutical dosage form compositions comprising mycophenolate sodium as active agent in an amount of from greater than about 720 mg to about 1500 mg, preferably from about 800 mg to about 1440 mg calculated as mycophenolic acid, and one or more pharmaceutically acceptable excipient(s). Particularly the dosage form compositions are meant for once-a-day or twice-a-day administration and provide the active agent in an extended release form which is released in a sustained manner in-vivo for a prolonged duration. The invention is also directed to process of manufacturing the high dose formulations, and prophylactic and/or therapeutic methods of using such dosage forms. The composition of the present inv...


Title: INJECTABLE BIODEGRADABLE POLYMER COMPOSITIONS FOR SOFT TISSUE REPAIR AND AUGMENTATION

Publication No: WO2009/044403
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61L 27/26 - JUVENIS LTD.
Methods for soft tissue repair and/or augmentation using injectable, biodegradable polymers are described herein. In one embodiment, the polymer compositions are liquid or pastes at room temperature. In a preferred embodiment, the polymer composition contains liquid or pasty hydroxy fatty acid-based copolyesters, polyester-anhydrides, or combinations thereof. The viscosity of the polymers increases upon contact with bodily fluid to form a solid or semisolid implant suitable for soft tissue repair and/or augmentation. In another embodiment, the polymer composition contains particles of a polymer stereocomplex. One or more active agents may be incorporated into the polymer compositions. Suitable classes of active agents include local anesthet...


Title: COSMETIC AND DERMOPHARMACEUTICAL COMPOSITIONS FOR SKIN BARRIER RESTORATION AND DISORDERS PREVENTION

Publication No: WO2009/044248
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61K 8/44 - SINERGA S.P.A.
The invention concerns compositions comprising a lipophilic matrix comprising at least 30% by weight of active compounds with respect to the composition weight, wherein said active compounds comprise at least 1 to 10% by weight of lecithin with respect to the composition weight. Such compositions find an advantageous application in cosmetics and in the preparation of formulations for the high-efficacy treatment on both skin barrier restoration and the reactivation of skin microcirculation, as well as for skin pigmentation.


Title: COMPOSITION AND METHOD FOR DERMAL REGENERATION

Publication No: WO2009/043111
Pub. Date - Int. Class - Applicant: - 09.04.2009 - A61K 31/736 - ULTRACEUTICALS R &D PTY LTD
The present invention relates to glucommannan oligosaccharides and polysaccharides that possess one or more properties selected from skin regeneration, wound healing and skin augmentation. More particularly, the invention relates to the use of glucomannan oligosaccharides and polysaccharides for one or more of skin regeneration, wound healing and skin augmentation agents in a mammal. The invention also relates to a pharmaceutical formulation for treating skin of a subject comprising an active component comprising glucomannan in a suitable diluent, excipient or physical form such as dermal scaffold or sponge, the active component being capable of promoting an accumulation of fibroblasts in the skin and stimulating production of collagen in t...


Title: BORON NITRIDE-CONTAINING SILICONE GEL COMPOSITION

Publication No: WO2009/038712
Pub. Date - Int. Class - Applicant: - 26.03.2009 - A61K 8/19 - MOMENTIVE PERFORMANCE MATERIALS INC.
A stable silicone oil composition is provided which comprises: a) at least one silicone gel; b) at least one boron nitride powder (a); c) a static charge-dissipating amount of at least one silicone oil; and, d) optionnally at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and/or absorbing agent, botanical extract, peptide, protein, organic oil, gum,...


Title: HYALURONIDASE AND METHOD OF USE THEREOF

Publication No: WO2009/037566
Pub. Date - Int. Class - Applicant: - 26.03.2009 - C12N 9/26 - UVARKINA, Tamara, P.
The present invention provides a tnaluronidase. The hyaiuronidase can be produced by the strain Streptomyces ai-tinocidm 77, Exemplary characteristics of the hyaluronidase include specific C -terminal or other amino acid sequences, including full-length sequences, and improved physico-chemical and actix itj properties as compared to known h> al?ronidase preparatkiiis. Described are also various uses of the hyaiur?nidasc, including topical administration of the h> aiuronidasc to improve skin penetration of a co-administered active substance.


Title: SIMULANT OF RADIOLOGICAL CONTAMINATION

Publication No: WO2009/032009
Pub. Date - Int. Class - Applicant: - 12.03.2009 - G01T 7/00 - CLEAN EARTH TECHNOLOGIES, LLC
A composition is formulated with generally regarded as safe (GRAS) ingredients for use as a non-radio-active simulant of radiological contamination such as fallout from a nuclear explosion, particulate from a radiological dispersal device, or contamination from operation of nuclear facilities. The compositions can be used for training exercises, testing, and research studies, and they can be applied safely to human skin. They include an ultraviolet (UV)-excited fluorescent ingredient that makes possible visible viewing of the simulants when illuminated by UV light. The chemical simulants have good fidelity with the physical properties of contamination, for example, adhesion, particle size, electrostatic charging, and response to decontamina...


Title: ANTIVIRAL TOPICAL FORMULATIONS IN THE FORM OF A BIO-ADHESIVE GEL

Publication No: WO2009/031006
Pub. Date - Int. Class - Applicant: - 12.03.2009 - A61K 9/06 - FIDIA FARMACEUTICI S.P.A.
The invention relates to topical formulations in the form of a bioadhesive hydrophilic gel comprising acyclovir as active ingredient, Sodium hyaluronate and an acrylic polymer. Said formulations improve the local administration of acyclovir in the treatment of herpes infections, because they possess good properties of adherence to the mucosa and high resistance to physiological removal mechanisms.


Title: COMPOSITION AND METHOD INHIBITING INFLAMMATION

Publication No: WO2009/027753
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 35/74 - FEHR, Jnos
Composition and method for preventing, treating or attenuating inflammatory diseases by way of inhibiting lipid peroxidation and subsequent elementary inflammation through ensuring the presence of the following biologically active ingredients in the PMRS of cells involved in inflammation: i) at least one killed probiotic and ii) at least one omega 3 FA and iii) vitamin E and iv) ubiquinone by introducing a composition comprising any of the missing ingredients.


Title: TRYPTASE INHIBITING MUSTARD EXTRACT

Publication No: WO2009/026944
Pub. Date - Int. Class - Applicant: - 05.03.2009 - A61K 36/31 - DSM IP ASSETS B.V.
The present invention relates to mustard extracts (Brassicaceae), in particular extracts of the Sinapis alba L. type and/or of the Sinapis arvensis L. type, and to active concentrates containing same and having potent tryptase inhibitory activity. These can be used for topical skin and scalp care applications in form of creams, lotions, gels, shampoos and the like, for the cosmetic treatment of the epidermal barrier. Barrier abnormalities and disruptions respectively are often the starting point of itching and inflammatory skin diseases.


Title: PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CELL PROLIFERATIVE DISEASE COMPRISING MIXTURE OF FEATHER OF BIRDS AND SCALE OF FISH AS AN ACTIVE INGREDIENT

Publication No: WO2009/022842
Pub. Date - Int. Class - Applicant: - 19.02.2009 - A61K 35/12 - LEE, Sang Moon
The present invention relates to a pharmaceutical composition for preventing and treating cell proliferative diseases comprising a feather of birds and a scale of fish, a scale transformed from the dermis, a degenerated or cornified variant of a scale, or a scale or horny scale of reptiles as an active ingredient. More particularly, the present invention relates to a pharmaceutical composition for preventing and treating cell proliferative diseases comprising a mixture of 70-85 weight% of a feather of birds and 15-30 weight% of a scale of fish, a scale transformed from the dermis, a degenerated or cornified variant of a scale, or a scale or horny scale of reptiles as an active ingredient. The inventive composition has the effect of inhibiti...


Title: DEPSIPEPTIDE DERIVATIVES AND THEIR THERAPEUTIC USE

Publication No: WO2009/022182
Pub. Date - Int. Class - Applicant: - 19.02.2009 - C07K 5/02 - KARUS THERAPEUTICS LIMITED
A compound of structure VII, VIII, IX or X wherein: R1, R2, R3, R4, R5, R6, R7 and R9 are the same or different and each represents an amino-acid side-chain moiety; each R10 is the same or different and represents hydrogen or C1-C6 alkyl, C2- C6 alkenyl, C2-C6 alkynyl or 5- or 6-membered aryl or heteroaryl; Pr is ...


Title: DHEA COMPOSITIONS FOR TREATING MENOPAUSE

Publication No: WO2009/021323
Pub. Date - Int. Class - Applicant: - 19.02.2009 - A61K 31/5685 - ENDORECHERCHE, INC.
Novel methods for treating or reducing the likelihood of acquiring symptoms or diseases due to the menopause, in postmenopausal women, particularly osteoporosis, vaginal atrophy and dryness, hypogonadism, diminished libido, skin atrophy, connective tissue disease, urinary incontinence, breast, endometrial, ovarian and uterine cancers, hot flashes, loss of muscle mass, insulin resistance, fatigue, loss of energy, aging, physical symptoms of menopause, in susceptible warm-blooded animals including humans involving administration of a sex steroid precursor are disclosed. Said method comprising novel ways of administering and dosing dehydroepiandrosterone (DHEA) in order to take advantage of positive androgenic effects in the vaginal layers lam...


Title: VESTIBULAR STIMULATION APPARATUS AND ASSOCIATED METHODS OF USE

Publication No: WO2009/020862
Pub. Date - Int. Class - Applicant: - 12.02.2009 - A61H 39/06 - SCION NEUROSTIM LLC
A device and associated method for providing vestibular stimulation to an individual includes active elements positioned on or proximate an ear insert. The active elements include but are not limited to at least one electrode, at least one thermometer, and at least one thermoelectric transducer. The device includes a computerized control module regulating the active elements. The device incorporates an ear insert that allows the active elements to engage the individual's ear canal and therefore access the individual's vestibular system. Vestibular stimulation applied to the individual is customized for directly stimulating desired regions of the brain for therapeutic or diagnostic purposes. In a preferred embodiment, the device provides ves...


Title: NEW GANODERMA TSUGAE VAR. JANNIEAE STRAIN TAY-I AND BIOLOGICALLY ACTIVE BIOMASS AND EXTRACTS THEREFROM

Publication No: WO2009/017462
Pub. Date - Int. Class - Applicant: - 05.02.2009 - A01H 15/00 - HYPHA HOLDINGS PTE LTD
A new and distinct variety of higher Basidiomycetes medicinal mushroom Ganoderma tsugae var. jannieae strain Tay-1 deposited under The Budapest Treaty with the Centralbureau voor Schimmelcultures (CBS) under Accession No. CBS 120394 is provided. Also provided are biomass and extracts of said mushroom rich in nutriceutical agents and biologically active compounds including proteins rich in essential amino acids and carbohydrates, vitamins, lipids rich in essential fatty acids, antioxidant agents, minerals, and melanin. The biomass and extracts are obtained from the fruiting bodies or the mycelial biomass, preferably a pure submerged mycelial culture. Compositions comprising biomass or extract are formulated into fo...


Title: COMPOSITION OF TUMOUR-ASSOCIATED PEPTIDES AND RELATED ANTI-CANCER VACCINE

Publication No: WO2009/015841
Pub. Date - Int. Class - Applicant: - 05.02.2009 - A61K 39/00 - IMMATICS BIOTECHNOLOGIES GMBH
The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti- tumour immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumour immune responses against colorectal cancer.


Title: MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON

Publication No: WO2009/014564
Pub. Date - Int. Class - Applicant: - 29.01.2009 - A61K 38/55 - THE UNIVERSITY OF TOLEDO
The present invention relates to a modified plasminogen activator inhibitor type- 1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI- 1, but is deficient in one or more functional activities as compared to the wild-type PAI- 1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following funtional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions c...


Title: A COMPOSITION THAT IS COMPRISING EXTRACTS, FRACTIONS OR ISOLATED SINGLE COMPOUNDS OF ROBINIA PSEUDO-ACACIA VAR. UMBRACULIFERA

Publication No: WO2009/014315
Pub. Date - Int. Class - Applicant: - 29.01.2009 - A61K 36/48 - KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
The present invention relates to a composition containing the extract of Robinia pseudo-acacia var. umbraculifera(Robinia pseudo-acacia var. umbraculifera) , fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition containing the extract of Robinia pseudo-acacia var. umbraculifera extracted with water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom such as amorphastilbol or 5, 7-dihydroxy-6-geranyl flavanone, or its pharmaceutically acceptable salts which can activate peroxisome proliferator-activated receptor (PPAR) to bring the effect of prevention or treatment of obesity, diabetes, inflammat...


Title: INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY

Publication No: WO2009/009793
Pub. Date - Int. Class - Applicant: - 15.01.2009 - A61K 31/517 - UNIVERSITY OF SOUTH FLORIDA
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering an effective amount of a compound of formula I to the person or animal.


Title: STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES

Publication No: WO2009/007785
Pub. Date - Int. Class - Applicant: - 15.01.2009 - A61K 9/12 - FOAMIX LTD.
A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of a...


Title: PESTICIDAL EAR TAG

Publication No: WO2009/005513
Pub. Date - Int. Class - Applicant: - 08.01.2009 - A01N 25/34 - Y-TEX CORPORATION
Pesticidal compositions and articles providing topical application of a mixture of (1) a macrolide of the avermectin/milbemycin class, such as, but not limited to ivermectin, abamectin, or milbemectin, and (2) a synergist of the aryl aliphatic ether-class, such as, but not limited to piperonyl butoxide, present in (3) a weight ratio of synergist:macrolide that is great than 1 :1. The compositions and articles demonstrate efficacy, even in point-of-contact applications, against various pests of domestic animals, such as, but not limited to arthropod ectoparasites including horn flies and buffalo flies. Methods are provided in which compositions can be employed as pour-ons, spot-ons, dusts, or sprays for direct topical application to the dome....
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WORLD PATENTS IN ACTIVES FOR SKIN CARE GRANTED IN  2009
This list includes patent documents published by the World Intellectual Property Organization (WIPO). The list was retrieved by searching the claims section of all patent applications
published. Salient search terms include skin care active ingredients having properties such as anti-ageing, anti-wrinkle, antioxidant, acne control benefits, skin whitening or lightening,
blemish removal, etc. This category includes technology related to the synthesis and delivery of actives such as peptides, exfoliants, α-hydroxy acids, herbals, free radical scavenger, "green"
derived molecules, etc.