US Patent Applications in Skin Care Actives and Formulations Published in 2009

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US PATENT APPLICATIONS IN SKIN CARE ACTIVES PUBLISHED IN 2009



Application No.: US20090003920A1  Published: 01/Jan/2009

Title: PERSONAL CARE PRODUCT HAVING A SOLID PERSONAL CARE COMPOSITION WITHIN A STRUCTURE MAINTAINING DISPENSER

Applicant/Assignee:

Application No.: 12/037536   Filing Date: 26/Feb/2008

Abstract:A personal care product is disclosed comprising a personal care composition and a dispensing container having the personal care composition disposed therein. The personal care composition may have a pre-dispense G' of at least about 5,000 Pa. The personal care product provides a G' preservation percentage of no less than 10%. The dispensing container may comprise a container body having a storage void containing the personal care composition, a movable partition at least partially disposed within the storage void, a drive mechanism connected to and able to advance the movable partition, and a dispensing plate joined to the container body. The dispensing plate has an orifice through which the personal care composition is dispensed. The orifice may have an inscribed circle diameter of about 1 mm to about 12 mm.

Priority: US20070903634P Applic. Date: 2007-02-27

Inventor: ZUKOWSKI JOSEPH MICHAEL [US]; LEPPLA NANCY LORINCZ [US]; ZHU CHU [US]; CILLEY ANN MARIE [US]; BREYFOGLE LAURIE ELLEN [US]


Application No.: US20090004125A1  Published: 01/Jan/2009

Title: Dispersions of polymers in organic medium, and compositions comprising them

Applicant/Assignee: L'OREAL

Application No.: 12/218391   Filing Date: 15/Jul/2008

Abstract:The invention relates to self-stabilized dispersions of polymer particles in a non-aqueous non-silicone medium, and to a process for preparing the said polymers. The invention also relates to cosmetic or pharmaceutical compositions comprising the said polymer particle dispersions.

Priority: FR20020015737 Applic. Date: 2002-12-12; FR20020015738 Applic. Date: 2002-12-12; US2003-735156 Applic. Date: 2003-12-12

Inventor: LION BERTRAND [FR]


Application No.: US20090004128A1  Published: 01/Jan/2009

Title: Non-Irritant Rapid-Action Dipilatory Composition

Applicant/Assignee: PRODUCCIONES INFOVISION

Application No.: 11/718306   Filing Date: 24/Oct/2005

Abstract:The invention relates to a rapid-action depilatory composition, comprising at least one bisulphic and/or sulphite compound and an organic reducing agent in a cosmetically acceptable medium.

Priority: FR20040011594 Applic. Date: 2004-10-29; WO2005FR02642 Applic. Date: 2005-10-24

Inventor: FLORK MICHEL [FR]


Application No.: US20090004161A1  Published: 01/Jan/2009

Title: Methods for treating pustular conditions of the skin

Applicant/Assignee:

Application No.: 12/215092   Filing Date: 25/Jun/2008

Abstract:The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

Priority: US20070937231P Applic. Date: 2007-06-26

Inventor: PALLADINO LINDA O [US]; MARSHALL VIVIENNE S [US]; CLARKE DIANA L [US]; SMITH CHARLOTTE A [US]; ROBSON MARTIN C [US]


Application No.: US20090004191A1  Published: 01/Jan/2009

Title: Expansion of Stem/Progenitor Cells by Inhibition of Enzymatic Reactions Catalyzed by the Sir2 Family of Enzymes

Applicant/Assignee:

Application No.: 11/631992   Filing Date: 14/Jul/2005

Abstract:Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.

Priority: US20040587496P Applic. Date: 2004-07-14; WO2005IL00753 Applic. Date: 2005-07-14

Inventor: PELED TONY [IL]


Application No.: US20090004199A1  Published: 01/Jan/2009

Title: ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F AND METHODS OF USING THE SAME

Applicant/Assignee: ZYMOGENETICS, INC

Application No.: 11/741189   Filing Date: 27/Apr/2007

Abstract:The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, an methods of using the same in inflammation.

Priority: US2007-684907 Applic. Date: 2007-03-12; US20060781121P Applic. Date: 2006-03-10; US20060828271P Applic. Date: 2006-10-05; US20060862501P Applic. Date: 2006-10-23

Inventor: JASPERS STEPHEN R [US]; PRESNELL SCOTT R [US]; HUBER MONICA [US]


Application No.: US20090004209A1  Published: 01/Jan/2009

Title: 4'-O- substituted isoindoline derivatives and compositions comprising and methods of using the same

Applicant/Assignee:

Application No.: 12/077715   Filing Date: 19/Mar/2008

Abstract:Provided are 4'-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US20070919323P Applic. Date: 2007-03-20

Inventor: RUCHELMAN ALEXANDER L [US]; MULLER GEORGE W [US]; MAN HON-WAH [US]


Application No.: US20090004236A1  Published: 01/Jan/2009

Title: PESTICIDAL EAR TAG

Applicant/Assignee:

Application No.: 12/042711   Filing Date: 05/Mar/2008

Abstract:Pesticidal compositions and articles providing topical application of a mixture of (1) a macrolide of the avermectin/milbemycin class, such as, but not limited to ivermectin, abamectin, or milbemectin, and (2) a synergist of the aryl aliphatic ether-class, such as, but not limited to piperonyl butoxide, present in (3) a weight ratio of synergist:macrolide that is great than 1:1. The compositions and articles demonstrate efficacy, even in point-of-contact applications, against various pests of domestic animals, such as, but not limited to arthropod ectoparasites including horn flies and buffalo flies. Methods are provided in which compositions can be employed as pour-ons, spot-ons, dusts, or sprays for direct topical application to the domestic animal

or in which articles comprising a polymer resin base, such as an ear tag, from which the active ingredients of the composition can be released, are affixed to the animal to provide long-term delivery.

Priority: WO2007US21243 Applic. Date: 2007-10-03; US20070947265P Applic. Date: 2007-06-29

Inventor: KELLERBY JOE D [US]


Application No.: US20090004278A1  Published: 01/Jan/2009

Title: Enzymatically Crosslinked Protein Nanoparticles

Applicant/Assignee: FUJIFILM CORPORATION

Application No.: 12/160175   Filing Date: 30/Jan/2007

Abstract:It is an object of the present invention to provide highly safe nanoparticles made from highly biocompatible materials without the use of a surfactant or synthetic polymer. The present invention provides a protein nanoparticle which is obtained by enzymatic crosslinking during and/or after the formation of protein nanoparticle.

Priority: JP20060020020 Applic. Date: 2006-01-30; JP20060326640 Applic. Date: 2006-12-04; WO2007JP51856 Applic. Date: 2007-01-30

Inventor: AIMI MAKIKO [JP]; NEMORI RYOICHI [JP]; MIYASHITA YOUSUKE [JP]; YOKOYAMA HIROSHI [JP]


Application No.: US20090004280A1  Published: 01/Jan/2009

Title: KIT FOR CARING FOR THE SKIN INTENDED TO SOFTEN CUTANEOUS SIGNS OF AGEING

Applicant/Assignee: L'OREAL

Application No.: 12/208484   Filing Date: 11/Sep/2008

Abstract:A kit for skin care intended to soften cutaneous signs of ageing, contains in separate packagings, a microdermabrasion composition, a peeling composition, a soothing composition and an anti-ageing composition.

Priority: FR20040053043 Applic. Date: 2004-12-17; US2005-287420 Applic. Date: 2005-11-28; US20050663202P Applic. Date: 2005-03-21

Inventor: MARION CATHERINE [FR]


Application No.: US20090004294A1  Published: 01/Jan/2009

Title: PERSONAL LUBRICANT FORMULATIONS COMPRISING COLLOIDAL METALS AND METHODS OF USE

Applicant/Assignee: PHARMWEST, INC

Application No.: 11/936696   Filing Date: 07/Nov/2007

Abstract:Lubricant compositions and methods are disclosed for aiding and enhancing massage or sexual activity, treating and preventing sexually transmitted diseases, and preventing pregnancy by administering a colloidal metal containing composition. Colloidal metal containing compositions that include metal flakes, sperm-function inhibitors, antimicrobial agents, analgesics, plant extracts, anti-oxidizing agents, and anti-inflammatory agents are also provided and may advantageously be used to in the methods of the invention.

Priority: US20060857270P Applic. Date: 2006-11-07

Inventor: MARGULIES JOEL [US]; JACOBS TERRY [US]


Application No.: US20090004307A1  Published: 01/Jan/2009

Title: Aloe Vera Extract, Method of Producing Aloe Vera Extract, and Hyperglycemia Improving Agent

Applicant/Assignee: MORINAGA MILK INDUSTRY CO., LTD

Application No.: 11/815428   Filing Date: 20/Nov/2006

Abstract:The present invention provides: an Aloe vera extract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods

and a method of producing the Aloe vera extract. A supercritical fluid extraction method can produce an Aloe vera extract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2): (1) the mass mixing ratio of the cyclolanostane compound and lophenol compound is as follows: cyclolanostane compound: lophenol compound=6.3:2.7 to 5.1:4.9

and/or (2) the content of an anthraquinone-based compound is 0.001% by mass or less.

Priority: JP20050340245 Applic. Date: 2005-11-25; WO2006JP323095 Applic. Date: 2006-11-20

Inventor: TANAKA MIYUKI [JP]; YAMADA MUNEO [JP]


Application No.: US20090005331A1  Published: 01/Jan/2009

Title: AChE antisense oligonucleotide as an anti-inflammatory agent

Applicant/Assignee: MOR RESEARCH APPLICATIONS LTD

Application No.: 11/788321   Filing Date: 18/Apr/2007

Abstract:Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

Priority: IL20030158600 Applic. Date: 2003-10-26; US2005-187719 Applic. Date: 2005-07-21; WO2004IL00978 Applic. Date: 2004-10-26

Inventor: SOREQ HERMONA [IL]; DORI AMIR [IL]; WIRGUIN ITZHAK [IL]; IFERGANE GAL [IL]; YIRMIYA RAZ [IL]


Application No.: US20090005368A1  Published: 01/Jan/2009

Title: Ethanol or 1,2-Ethanediol Cyclohexyl Antibiotic Derivatives

Applicant/Assignee: ACTELION PHARMACEUTICALS LTD

Application No.: 12/279329   Filing Date: 14/Feb/2007

Abstract:The invention relates to antibiotic ethanol or 1,2-ethanediol cyclohexyl derivatives of formula (I) wherein R1 represents (C1-C4)alkoxy

one or two of U, V, W and X represents) N and the remaining represent each independently CH or, in the case of V or X, may also represent CRa

Ra represents halogen

R2 represents H or OH

A represents CH2, CO, CH2CH-CH or COCH-CH

D represents a phenyl group optionally substituted one or two times by halogen atoms, or D represents a group of the formula (II) in which Q is oxygen or sulphur

and to salts of these derivatives of formula (I).

Priority: WO2006IB50505 Applic. Date: 2006-02-15; WO2007IB50482 Applic. Date: 2007-02-14

Inventor: HUBSCHWERLEN CHRISTIAN [FR]; SURIVET JEAN-PHILIPPE [FR]; ZUMBRUNN ACKLIN CORNELIA [CH]


Application No.: US20090005438A1  Published: 01/Jan/2009

Title: Use of Isothiocyanates Compounds in Treating Prostatic Diseases and Skin Cancer

Applicant/Assignee: WUXI JC PHARMACEUTICAL TECHNOLOGY CO., LTD

Application No.: 12/093829   Filing Date: 14/Nov/2006

Abstract:A method for preventing and treating prostatic diseases and skin cancer using naturally or artificially synthesized isothiocyanates compounds or the derivatives or metabolites thereof.

Priority: CN20051095737 Applic. Date: 2005-11-15; CN20061038112 Applic. Date: 2006-01-27; WO2006CN03062 Applic. Date: 2006-11-14

Inventor: CHENG JINGCAI [CN]; CHIAO JENWEI [CN]; JIN HAIYA [CN]; ZHONG CHENGJUAN [CN]


Application No.: US20090005452A1  Published: 01/Jan/2009

Title: Diphenyl Urea Derivatives

Applicant/Assignee: ARIPIDA AG ARPIDA AG

Application No.: 12/096831   Filing Date: 08/Dec/2006

Abstract:The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Priority: WO2005EP13345 Applic. Date: 2005-12-13; WO2006EP11795 Applic. Date: 2006-12-08

Inventor: LOEWE RALF [CH]; LOCIURO SERGIO [CH]; HAWSER STEPHEN [FR]; SCHMITT LAURENT [FR]


Application No.: US20090005722A1  Published: 01/Jan/2009

Title: Skin-contacting-adhesive free dressing

Applicant/Assignee:

Application No.: 12/231104   Filing Date: 29/Aug/2008

Abstract:A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body portion, the sleeve having a lining which is substantially non-adherent to the body part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.

Priority: US2006-434689 Applic. Date: 2006-05-16

Inventor: JENNLNGS-SPRING BARBARA [US]


Application No.: US20090010862A1  Published: 08/Jan/2009

Title: FOAMING OIL COMPOSITIONS

Applicant/Assignee:

Application No.: 12/147074   Filing Date: 26/Jun/2008

Abstract:A personal care composition comprising an oil and a siloxane resin foam stabilizer, said composition being substantially free of surfactants and propellants, is provided. The composition is capable of foaming, and is advantageously clear and non-greasy.

Priority: EP20070012898 Applic. Date: 2007-07-02

Inventor: ARIF AMBAREEN [CH]; MUTTI BRUNA [DE]; ROUET SOPHIE [FR]


Application No.: US20090010863A1  Published: 08/Jan/2009

Title: Cosmetic Compositions

Applicant/Assignee: THE BOOTS COMPANY PLC

Application No.: 11/577451   Filing Date: 13/Oct/2005

Abstract:There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises two or more active ingredients selected from the group consisting of a) dipalmitoyl hydroxyproline, salts and esters thereof

b) carnitine

and c) an extract of Haematococcus pluvialis. Compositions prepared in accordance with the invention are useful for improving the appearance of the skin.

Priority: GB20040023164 Applic. Date: 2004-10-19; US20050712396P Applic. Date: 2005-08-31; WO2005GB03946 Applic. Date: 2005-10-13

Inventor: BARTON STEPHEN PETER [GB]; LONG STEWART PAUL [GB]; HAMILTON LLOYD GEORGE [GB]


Application No.: US20090010864A1  Published: 08/Jan/2009

Title: Low residue deodorant or antiperspirant stick based on an ethanol-containing oil-in-water dispersion/emulsion

Applicant/Assignee:

Application No.: 11/960348   Filing Date: 19/Dec/2007

Abstract:Deodorant or antiperspirant sticks based on an ethanol-containing oil-in-water dispersion/emulsion for application on the skin.

Priority: DE200510029777 Applic. Date: 2005-06-24; DE200610021780 Applic. Date: 2006-05-09; WO2006EP05787 Applic. Date: 2006-06-16; US20060788023P Applic. Date: 2006-03-30; US20060799160P Applic. Date: 2006-05-10

Inventor: BANOWSKI BERNHARD [DE]; WADLE ARMIN [DE]; CLAAS MARCUS [DE]


Application No.: US20090010869A1  Published: 17/Jan/2008

Title: Compositions for Topical Enzymatic Debridement

Applicant/Assignee: COLLEGIUM PHARMACEUTICAL, INC

Application No.: 11/843158   Filing Date: 22/Aug/2007

Abstract:Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

Priority: US2005-147567 Applic. Date: 2005-06-08; US20050642835P Applic. Date: 2005-01-11; US20040608991P Applic. Date: 2004-09-10; US20040604900P Applic. Date: 2004-08-27; US20040580085P Applic. Date: 2004-06-16

Inventor: TRUMBORE MARK W [US]; RARIY ROMAN V [US]; HIRSH MARK [US]; HIRSH JANE C [US]; SAUNDERS JULIE A [US]


Application No.: US20090010873A1  Published: 08/Jan/2009

Title: Methods of Cell Therapy, Neurogenesis and Oligodendrogenesis

Applicant/Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 11/720417   Filing Date: 29/Nov/2005

Abstract:A method is provided for inducing and enhancing neurogenesis and/or oligodendrogenesis from endogenous as well as from exogenously administered stem cells, which comprises administering to an individual in need a neuroprotective agent such as a nervous system (NS)-specific antigen, a peptide derived therefrom, T cells activated therewith, poly-YE, microglia activated by IFN-gamma and/or IL-4 and combinations thereof. The method includes stem cell therapy in combination with the neuroprotective agent.

Priority: US20040631163P Applic. Date: 2004-11-29; WO2005IL01270 Applic. Date: 2005-11-29

Inventor: EISENBACH-SCHWARTZ MICHAL [IL]; BUTOVSKY OLEG [IL]; ZIV YANIV [IL]; KIFNIS JONATHAN [IL]; RON NOGA [IL]


Application No.: US20090010910A1  Published: 08/Jan/2009

Title: COMPOSITIONS AND METHODS FOR DERMATOLOGICAL WOUND HEALING

Applicant/Assignee: MEDIWOUND LTD

Application No.: 11/571880   Filing Date: 13/Jul/2005

Abstract:The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present invention further relates to kit and methods for topical debridement of damaged skin, particularly of burned skin.

Priority: US20040587057P Applic. Date: 2004-07-13; WO2005IL00744 Applic. Date: 2005-07-13

Inventor: TOREN AMIR [IL]; ROSENBERG LIOR [IL]; GORECKI MARIAN [IL]


Application No.: US20090010946A1  Published: 08/Jan/2009

Title: Novel Stromal Cell-Derived Factor-1 Polypeptides, Polynucleotides, Modulators Thereof and Methods of Use

Applicant/Assignee: FIVE PRIME THERAPEUTICS, INC

Application No.: 11/587651   Filing Date: 29/Apr/2005

Abstract:Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

Priority: US20040567311P Applic. Date: 2004-04-30; WO2005US14963 Applic. Date: 2005-04-29

Inventor: CHU KETING [US]; WILLIAMS LEWIS T [US]; WONG JUSTIN G P [US]; HESTIR KEVIN [US]; COLLINS AMY L TSUI [US]; LEE ERNESTINE [US]


Application No.: US20090010968A1  Published: 08/Jan/2009

Title: Spot-on formulation useful for cosmetology and dermatology

Applicant/Assignee:

Application No.: 11/596334   Filing Date: 12/May/2005

Abstract:The invention relates to a novel formulation of use in cosmetology and in dermatology which uses the storage capacity of the sebaceous glands. The formulation is of the spot-on type and comprises a lipophilic active principle chosen from vitamin A, vitamin E a lipophilic agent for combating free radicals, ceramides or sphingoid bases and steroid hormones, in combination with one or more unsaturated C4-C26 fatty acids and a liquid vehicle, having sebaceous tropism. Application to the localized topical administration of lipophilic active principles.

Priority: FR20040005136 Applic. Date: 2004-05-12; WO2005FR01188 Applic. Date: 2005-05-12

Inventor: ALLART JEAN-CLAUDE [FR]; LEFEVRE JEAN-MARIE [FR]; PEYROT JACQUES [FR]; MARTY JEAN-PAUL [FR]


Application No.: US20090010976A1  Published: 08/Jan/2009

Title: Cosmetic or dermopharmaceutical compositions containing kombucha

Applicant/Assignee: SEDERMA

Application No.: 12/231114   Filing Date: 29/Aug/2008

Abstract:Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

Priority: FR20020009710 Applic. Date: 2002-07-30; US2005-523333 Applic. Date: 2005-08-29; WO2003FR02368 Applic. Date: 2003-07-25

Inventor: LINTNER KARL [FR]


Application No.: US20090010978A1  Published: 08/Jan/2009

Title: Green tea jewelry

Applicant/Assignee: SOUTHERLEE INCORPORATED

Application No.: 12/231096   Filing Date: 28/Aug/2008

Abstract:A method for making green tea jewelry is provided. The jewelry may be worn as a transdermal source of green tea components used as an alternative to or in addition to ingestion of green tea liquid or solids. Also provided is a kit for providing green tea jewelry in a substantially water resistant and air-tight package. The kit may comprise additional articles such as informational inserts and scents.

Priority: US2006-379556 Applic. Date: 2006-04-20

Inventor: JENSEN DAVID MATTHEW [US]


Application No.: US20090010998A1  Published: 08/Jan/2009

Title: Drug-delivery patch comprising a dissolvable layer and uses thereof

Applicant/Assignee:

Application No.: 12/217393   Filing Date: 03/Jul/2008

Abstract:The present invention provides a drug-delivery patch having at least one dissolvable layer comprising an active material and an adhesive backing or cover. The present invention also provides a method of transdermally vaccinating an animal by ablating an area of the stratum corneum of the animal and applying the patch described herein to the area.

Priority: US20070947724P Applic. Date: 2007-07-03

Inventor: MARCHITTO KEVIN S [US]; FLOCK STEPHEN T [US]


Application No.: US20090011022A1  Published: 08/Jan/2009

Title: Use of deuterium oxide for treatment of virus-based diseases of the skin

Applicant/Assignee:

Application No.: 12/168583   Filing Date: 07/Jul/2008

Abstract:The present invention relates to the use of deuterium dioxide (D2O) for prevention and/or treatment of virus-based diseases of the skin, in particular herpes virus-based and verrucal virus-based diseases of the skin.

Priority: DE200710031397 Applic. Date: 2007-07-05

Inventor: BAYERL THOMAS M [GB]


Application No.: US20090011026A1  Published: 08/Jan/2009

Title: TRANSCORNEAL SYSTEM FOR DELIVERY OF A PHARMACEUTICAL AGENT

Applicant/Assignee:

Application No.: 12/063876   Filing Date: 23/Aug/2006

Abstract:The invention relates to a transcorneal system for delivery of a pharmaceutical agent, made from a matrix material forming a baseplate (1), said baseplate (1) being connected to a number of projections (4) for penetration of the Stratum corneum of the skin, said projections (4) being made from the matrix material and comprising the agent.

Priority: DE200510040251 Applic. Date: 2005-08-24; WO2006EP65585 Applic. Date: 2006-08-23

Inventor: EGEN MARC [DE]; PICCINI MARIA [DE]; GESER JOHANNES [DE]; FEIERTAG CHRISTIAN [DE]


Application No.: US20090011035A1  Published: 08/Jan/2009

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/825103   Filing Date: 03/Jul/2007

Abstract:Stable personal care composition comprising from about 0.1% to about 15% of a non-emulsifying crosslinked siloxane elastomer

from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer

from about 1% to about 40% of an elastomer solvent

less than 0.1% of a solidifying agent

an aqueous phase comprising from about 0.0001% to about 10%, by weight of the composition, of a hydrophilic colorant

whereupon application of shear force to the composition a visibly enhanced aqueous phase is visibly separated from the non-aqueous phase.

Priority:

Inventor: ZUKOWSKI JOSEPH MICHAEL [US]; GRIFFITHS-BROPHY SUSAN ADAIR [US]; VATTER MICHAEL LEE [US]; CONSTANTINIDES IOANNIS CONSTANTINE [US]; ZHU CHU [US]


Application No.: US20090012002A1  Published: 08/Jan/2009

Title: COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING PEPTIDES, USES AND TREATMENT PROCESSES

Applicant/Assignee: SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS S.A

Application No.: 12/134795   Filing Date: 06/Jun/2008

Abstract:The present invention has as an aim a cosmetic and/or dermatological and/or pharmaceutical composition comprising, as an active ingredient, at least a peptide of sequence X1-Y-Phe-Thr-X2-Ala-Thr-Z-Ile-X3-Leu-X4-Phe-Leu-X5 (SEQ ID NO: 1)

wherein: X1, X2, X3, X4, X5=Arg, Lys, His

Y=Asp, Glu

Z=Asn, Gln, or one of its fragment containing from 4 to 7 amino acids, and the motif Phe-Leu. The invention also relates to a method for preventing or treating skin against the manifestations of cutaneous aging.

Priority: FR20020003306 Applic. Date: 2002-03-18; FR20080000611 Applic. Date: 2008-02-06; US2004-508245 Applic. Date: 2004-09-20; WO2003FR00817 Applic. Date: 2003-03-14

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]


Application No.: US20090012059A1  Published: 08/Jan/2009

Title: DIPEPTIDYL PEPTIDASE INHIBITORS

Applicant/Assignee:

Application No.: 11/929593   Filing Date: 30/Oct/2007

Abstract:Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4

Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C-NR9

and each L, X, R1, R2, and R3 are as defined herein.

Priority: US2005-080992 Applic. Date: 2005-03-15; US20040553571P Applic. Date: 2004-03-15; US20040629524P Applic. Date: 2004-11-18

Inventor: FENG JUN [US]; GWALTNEY STEPHEN L [US]; STAFFORD JEFFREY A [US]; ZHANG ZHIYUAN [US]; ELDER BRUCE J [US]; ISBESTER PAUL K [US]; PALMER GRANT J [US]; SALSBURY JONATHON S [US]; ULYSSE LUCKNER G [US]


Application No.: US20090012071A1  Published: 08/Jan/2009

Title: 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

Applicant/Assignee: ACHILLION PHARMACEUTICALS, INC

Application No.: 12/108106   Filing Date: 23/Apr/2008

Abstract:The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound as the only active agent or in combination with one or more other active agents. The invention provides methods for treating or preventing microbial infections, preferably animals, by administering an effective amount of a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound to an organism suffering from or susceptible to microbial infection. The invention also provides methods of inhibiting microbial growth and survival by applying an effective amount of a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound.

Priority: US20070913404P Applic. Date: 2007-04-23

Inventor: BRADBURY BARTON JAMES [US]; DESHPANDE MILIND [US]; HASHIMOTO AKIHIRO [US]; KIM HA YOUNG [US]; LUCIEN EDLAINE [US]; PAIS GODWIN [US]; PUCCI MICHAEL JOHN [US]; WANG QIUPING [US]; WILES JASON ALLAN [US]


Application No.: US20090012097A1  Published: 08/Jan/2009

Title: Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators

Applicant/Assignee: IRM LLC

Application No.: 12/160305   Filing Date: 25/Jan/2007

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US20060763623P Applic. Date: 2006-01-30; WO2007US02115 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT [US]; COW CHRISTOPHER [US]


Application No.: US20090012155A1  Published: 08/Jan/2009

Title: Composition Of Skin External Application For Anti-Aging

Applicant/Assignee:

Application No.: 12/064887   Filing Date: 08/Sep/2006

Abstract:The present invention relates to an anti-aging composition for external use on skin, and more particularly, to an anti-aging composition for external use on skin comprising at least one of catechins and flavonols as an active ingredient to inhibit decomposition and promote generation or protection at the dermis-epidermis junction.

Priority: KR20050083665 Applic. Date: 2005-09-08; KR20050083667 Applic. Date: 2005-09-08; KR20060021797 Applic. Date: 2006-03-08; WO2006KR03571 Applic. Date: 2006-09-08

Inventor: KIM JEONG KI [KR]; SHIN HYUN JUNG [KR]; KIM SU NAM [KR]; LEE BYEONG GON [KR]; CHANG IH SEOP [KR]


Application No.: US20090012159A1  Published: 08/Jan/2009

Title: HIGH PURITY BASES OF 3,3-DIPHENYLPROPYLAMINO MONOESTERS

Applicant/Assignee:

Application No.: 12/141489   Filing Date: 18/Jun/2008

Abstract:The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterised in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments.

Priority: DE20031015917 Applic. Date: 2003-04-08; US2005-532836 Applic. Date: 2005-04-26; WO2004EP03567 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]


Application No.: US20090012174A1  Published: 08/Jan/2009

Title: Compositions Having a High Antiviral and Antibacterial Efficacy

Applicant/Assignee: THE DIAL CORPORATION

Application No.: 12/188714   Filing Date: 08/Aug/2008

Abstract:Antimicrobial compositions having a rapid antiviral and antibacterial effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain (a) a disinfecting alcohol, (b) an organic acid, (c) a buffering agent, and (d) water, wherein the composition has a pH of about 5 or less.

Priority: US2008-791257 Applic. Date: 2008-03-04; WO2005US43910 Applic. Date: 2005-12-05; US20040634464P Applic. Date: 2004-12-09

Inventor: SEITZ JR EARL P [US]; THEILER RICHARD F [US]; FOX PRISCILLA S [US]


Application No.: US20090012462A1  Published: 08/Jan/2009

Title: REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION

Applicant/Assignee: PROMETHEAN SURGICAL DEVICES INC

Application No.: 12/162039   Filing Date: 24/Jan/2007

Abstract:A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.

Priority: US20060762302P Applic. Date: 2006-01-26; WO2007US01830 Applic. Date: 2007-01-24

Inventor: MILBOCKER MICHAEL T [US]; WILSON JEFFREY A [US]


Application No.: US20090012494A1  Published: 08/Jan/2009

Title: INTRADERMAL DELIVERY OF BIOLOGICAL AGENTS

Applicant/Assignee: NANOPASS TECHNOLOGIES LTD

Application No.: 11/946889   Filing Date: 29/Nov/2007

Abstract:The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.

Priority: GB20060020617 Applic. Date: 2006-10-17; WO2007IL01244 Applic. Date: 2007-10-17

Inventor: YESHURUN YEHOSHUA [IL]; LEVIN YOTAM [IL]; ALMAGOR YOTAM [IL]; LAVI GILAD [IL]; HEFETZ MEIR [IL]; SEFI YOEL [IL]; CATCHPOLE RICHARD IAN [GB]


Application No.: US20090013417A1  Published: 08/Jan/2009

Title: Transgenic Animals for Assessing Drug Metabolism and Toxicity in Man

Applicant/Assignee: IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED

Application No.: 10/597600   Filing Date: 24/Mar/2008

Abstract:A method of introducing at least one human cytochrome P450 into a non-human animal c ell in which corresponding endogenous P450 enzyme activities have been disabled, thus the method provides a way of using a non-human animal cell to make predictions regarding P450-mediated metabolism in a human. The present invention also provides transgenic non-human animals produced by the method of the invention and uses therefor, especially in assessing xenobiotic/drug metabolism and toxicity.

Priority: GB20040002318 Applic. Date: 2004-02-03; WO2005GB00382 Applic. Date: 2005-02-03

Inventor: WOLF CHARLES ROLAND [GB]; HENDERSON COLIN J [GB]


Application No.: US20090016970A1  Published: 15/Jan/2009

Title: CONTINUOUS SPRAY SCALP THERAPY AND DISPENSING SYSTEMS FOR SAME

Applicant/Assignee:

Application No.: 12/193153   Filing Date: 18/Aug/2008

Abstract:A spray delivery system in combination with a scalp medication is provided which includes a portable container having a gas imperious container wall, a pressure source disposed within the container, and a selectively operable valve assembly affixed to the container. The scalp medication is in liquid form and is disposed within the container. The scalp medication comprises a hair growth stimulation or hair growth maintenance active ingredient in an amount sufficient to stimulate or maintain hair growth disposed within a pharmacologically acceptable carrier solution. The valve assembly of the system produces a 1 mL spray of said scalp medication within about 5 seconds following a single operation of said valve assembly. A method of treating alopecia using a continuous spray employing such a system is also provided. Both bag-on-valve (bag-in-can) and metered dose packages are disclosed.

Priority: WO2008US54754 Applic. Date: 2008-02-22; US2007-677777 Applic. Date: 2007-02-22

Inventor: CRONK PETER J [US]


Application No.: US20090016971A1  Published: 15/Jan/2009

Title: Aqueous fluid photoprotective compositions comprising tertiary-amide-terminated polyamide polymers

Applicant/Assignee: L'OREAL

Application No.: 12/216890   Filing Date: 11/Jul/2008

Abstract:Topically applicable, fluid anti-sun/sunscreen compositions useful for protecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system for screening out UV radiation

and (b) at least one tertiary-amide-terminated polyamide (ATPA) polymer, formulated into a topically applicable, cosmetically acceptable aqueous support therefor

the subject anti-sun/sunscreen compositions are especially provided as sprays, notably for the purpose of increasing the sun protection factor (SPF) and/or of reducing or even eliminating the fluffing effect thereof.

Priority: FR20070056456 Applic. Date: 2007-07-12; US20070959923P Applic. Date: 2007-07-18

Inventor: GAUDRY ANNE-LAURE [FR]; JOSSO MARTIN [FR]


Application No.: US20090016972A1  Published: 15/Jan/2009

Title: Oral cavity care curative and prophylactic composition

Applicant/Assignee:

Application No.: 12/094605   Filing Date: 19/Sep/2008

Abstract:The invention relates to stomatology and perfume industry in particular to therapeutic formulation for oral cavity care. The invention refers to oral hygiene means and can be applied for preparation of medical and prophylactic tooth-pastes, gels, liquids for oral care as well as other compositions like chewing gums, jellies, etc. Formulation containing orally applicable active and inert components involves bromelain in amount of 0.01/1 wt %, xylitol 1.5/20 wt %. At best bromelain content is 0.1-0.8 wt %, xylitol content-2.2-18 wt %. For attaining remineralizing effect formulation contains anti-carious mineral additive 0.05-3.0 wt % of the list of active components. At best anti-carious mineral additive content is 0.2-2.5 wt %. There are used calcium glycerophosphate and inorganic or organic magnesium salt as anti-carious mineral additive. It is acceptable to use sodium monofluorphosphate, potassium monofluorphosphate, calcium monofluorphosphate or magnesium monofluorphosphate in amount of 0.5-1.5 wt % as anti-carious mineral additive Optimum concentration is 0.8-1.1 wt %.

Priority: WO2005RU00601 Applic. Date: 2005-11-25

Inventor: MANASHEROV TAMAZI OMAROVICH [RU]; MATELO SVETLANA KONSTANTINOVNA [RU]; GROSSER ALEXANDR VLADIMIROVICH [RU]


Application No.: US20090016974A1  Published: 15/Jan/2009

Title: Application of dehydroascorbic acid or derivatives/isomers thereof for artificially coloring the skin

Applicant/Assignee: L'OREAL

Application No.: 12/216693   Filing Date: 09/Jul/2008

Abstract:Dehydroascorbic acid and polymeric/monomeric derivatives and isomers thereof are useful for artificially coloring the skin and more particularly as a skin self-tanning agent

the dehydroascorbic acid may be formed "in situ" from ascorbic acid or a derivative or salt thereof via chemical oxidation and/or via enzymatic oxidation, and a two-component agent thereof includes a) a first component (B) containing, in a physiologically acceptable medium, at least ascorbic acid or a derivative or salt thereof

b) a second component (C) containing, in a physiologically acceptable medium, at least one chemical oxidizing agent and/or one enzymatic oxidizing agent

components (B) and (C) being stored separately.

Priority: FR20070056353 Applic. Date: 2007-07-09; US20070929965P Applic. Date: 2007-07-19

Inventor: PRUCHE FRANCIS [FR]; CHOISY PATRICK [FR]


Application No.: US20090017036A1  Published: 15/Jan/2009

Title: PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS

Applicant/Assignee:

Application No.: 12/202784   Filing Date: 02/Sep/2008

Abstract:The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

Priority: EP20040018808 Applic. Date: 2004-08-07; US2005-189643 Applic. Date: 2005-07-26

Inventor: JUNG BIRGIT [DE]; HIMMELSBACH FRANK [DE]


Application No.: US20090017080A1  Published: 15/Jan/2009

Title: PERSONAL CARE KIT HAVING SKIN CARE COMPOSITIONS WITH A READILY PERCEPTIBLE DIFFERENCE

Applicant/Assignee:

Application No.: 12/047391   Filing Date: 13/Mar/2008

Abstract:A personal care kit comprises a first series of unit-dose packages containing a first skin care composition and a second series of unit-doses packages containing a second skin care composition, wherein the first skin care composition and the second skin care composition exhibit a readily perceptible difference. The readily perceptible difference may be a visible difference, a tactile difference, or an olfactory difference. The first and/or second skin care composition may comprise a skin care active. A method for using the personal care kit is also disclosed.

Priority: US20070918216P Applic. Date: 2007-03-15

Inventor: TANNER PAUL ROBERT [US]; ROBINSON LARRY RICHARD [US]; HA ROBERT BAO [US]; ZIMMERMAN DEAN ARTHUR [US]


Application No.: US20090017106A1  Published: 15/Jan/2009

Title: ADJUVANTS ON THE BASIS OF BISACYLOXYPROPYLCYSTENE CONJUGATES AND DERIVATIVES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS

Applicant/Assignee:

Application No.: 12/093865   Filing Date: 22/Nov/2006

Abstract:The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP20050025431 Applic. Date: 2005-11-22; WO2006EP11182 Applic. Date: 2006-11-22

Inventor: EBENSEN THOMAS [DE]; MORR MICHAEL [DE]; GUZMAN CARLOS [DE]


Application No.: US20090017129A1  Published: 15/Jan/2009

Title: Dead Sea minerals enriched anti-inflammatory pharmaceutical composition for treatment of cutaneous dryness, itching, peeling and tightness, especially in hemodialysis patients and preparation and treatment methods thereof

Applicant/Assignee:

Application No.: 12/171076   Filing Date: 10/Jul/2008

Abstract:This invention relates to Dead Sea anti-inflammatory medicaments or cosmetics for treatment of anti-inflammatory conditions

for example, cutaneous dryness, itching, peeling, and tightness, especially in hemodialysis patients. Methods for the preparation of and methods of treatment using these medicaments or cosmetics are also provided.

Priority: US20070929840P Applic. Date: 2007-07-13

Inventor: MA OR ZE EV [IL]; ROYZ MICHAEL [IL]; MAKOV SHARON [IL]; TZIONI TAMAR [IL]; MINGELGRIN MIRIAM ORON [IL]


Application No.: US20090017147A1  Published: 15/Jan/2009

Title: Cosmetic or Dermopharmaceutical Composition Comprising an Euglena Extract

Applicant/Assignee: SEDERMA

Application No.: 11/795330   Filing Date: 13/Jan/2006

Abstract:The invention provides a cosmetic or dermopharmaceutic composition containing an Euglena extract, its use to activate the cellular metabolism and in particular to protect and/or improve the state of the skin and to reduce the signs of ageing in particular and/or cutaneous fatigue

Priority: FR20050000431 Applic. Date: 2005-01-14; WO2006IB50135 Applic. Date: 2006-01-13

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]; LAMY LOUIS FRANCOIS [FR]; MONDON PHILIPPE [FR]


Application No.: US20090018124A1  Published: 15/Jan/2009

Title: Novel Benzoimidazole Derivatives and Pharmaceutical Composition Comprising the Same

Applicant/Assignee:

Application No.: 11/815009   Filing Date: 26/Jan/2006

Abstract:Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Priority: KR20050008183 Applic. Date: 2005-01-28; KR20050098349 Applic. Date: 2005-10-18; WO2006KR00324 Applic. Date: 2006-01-27

Inventor: KIM JI DUCK [KR]; YOON HONG CHUL [KR]; KIM IN WOO [KR]; HYUN HYAE JUNG [KR]


Application No.: US20090018185A1  Published: 15/Jan/2009

Title: COMPOSITIONS AND PRODUCTS CONTAINING S-EQUOL, AND METHODS FOR THEIR MAKING

Applicant/Assignee: AUSTRALIAN HEALTH & NUTRITION ASSOCIATION LIMITED CHILDREN'S HOSPITAL MEDICAL CENTER

Application No.: 12/167813   Filing Date: 03/Jul/2008

Abstract:A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

Priority: US2003-625934 Applic. Date: 2003-07-24; US20020398270P Applic. Date: 2002-07-24

Inventor: SETCHELL KENNETH DAVID REGINALD [US]; COLE SIDNEY JOHN [AU]


Application No.: US20090018200A1  Published: 15/Jan/2009

Title: COMPOSITION CONTAINING A PHENANTHRENOL

Applicant/Assignee: L'OREAL

Application No.: 12/172354   Filing Date: 14/Jul/2008

Abstract:Novel uses of phenanthrenol compounds for improving the appearance and/or texture of the skin.

Priority: US20070949295P Applic. Date: 2007-07-12

Inventor: WILLEMIN CLAUDIE [FR]; REMAUT GEOFFROY [FR]; FONOLLA MORENO ANGELES [FR]; LEMOINE CYRIL [FR]


Application No.: US20090018214A1  Published: 15/Jan/2009

Title: Composition for Promoting Vascular Smooth Muscle Relaxation

Applicant/Assignee:

Application No.: 12/223583   Filing Date: 23/Jan/2007

Abstract:A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a "virtual injection" of the active ingredient to be delivered transdermally without general systemic uptake.

Priority: GB20060002224 Applic. Date: 2006-02-03; WO2007GB00212 Applic. Date: 2007-01-23

Inventor: DAVIS ADRIAN FRANCIS [GB]


Application No.: US20090018481A1  Published: 15/Jan/2009

Title: PLASTER WHICH RELEASES ACTIVE COMPOUND

Applicant/Assignee:

Application No.: 12/168938   Filing Date: 08/Jul/2008

Abstract:The invention relates to a medical plaster which is able to supply damaged skin and open wounds with an active compound which helps to accelerate wound healing and allows it to proceed better. The plaster has novel design features which enable, in particular, protein- or peptide-containing medicaments, such as, for example, erythro-poietin (EPO), to exert their wound-healing or wound-healing-promoting action by release of the active compound from the plaster without being significantly deactivated or metabolized in the process by substances occurring in the wound secretion.

Priority: EP20070013361 Applic. Date: 2007-07-09

Inventor: BADER AUGUSTINUS [DE]


Application No.: US20090022674A1  Published: 22/Jan/2009

Title: COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING OLIGOPEPTIDES FOR LIGHTENING THE SKIN OF AGE MARKS AND/OR FOR PREVENTING TANNING OF THE SKIN, IN PARTICULAR TANNING OF THE SKIN CAUSED BY UV RADIATION

Applicant/Assignee: BEIERSDORF AG

Application No.: 12/175994   Filing Date: 18/Jul/2008

Abstract:Cosmetic or pharmaceutical preparations which are distinguished by an effective content of one or more monomeric or homo- or heterodimeric or homo- or heterotrimeric or homo- or heterotetrameric oligopeptides, where these oligopeptides are based on a Structure Val-Val-Arg-Pro SEQ ID NO: 1 as homo- or heteromonomer.

Priority: US1998-132799 Applic. Date: 1998-08-13

Inventor: SCHONROCK UWE [DE]; MAX HEINER [DE]; HEARING VINCENT J [US]


Application No.: US20090022700A1  Published: 22/Jan/2009

Title: Cosmetic water-soluble film

Applicant/Assignee: L'OREAL

Application No.: 12/081909   Filing Date: 23/Apr/2008

Abstract:The present invention relates to a composition which is in the form of a water-soluble anhydrous film comprising at least one water-soluble or water-dispersible film-forming polymer, and at least one live, in particular probiotic, microorganism. It also relates to a kit containing such a composition, as a combination with a secondary composition.

Priority: FR20070054766 Applic. Date: 2007-04-27; US20070941735P Applic. Date: 2007-06-04

Inventor: CASSIN GUILLAUME [FR]; SIMONNET JEAN-THIERRY [FR]


Application No.: US20090022712A1  Published: 22/Jan/2009

Title: Compositions and Methods for Inhibiting Leukocyte Function

Applicant/Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Application No.: 12/161915   Filing Date: 24/Jan/2007

Abstract:The present invention provides compositions and methods for regulating leukocyte migration and function. The present invention also provides compositions and methods for preventing and inhibiting lung injury and damage associated with neutrophil infiltration of the lung.

Priority: US20060761471P Applic. Date: 2006-01-24; WO2007US02077 Applic. Date: 2007-01-24

Inventor: REUTERSHAN JOERG [DE]; SCHWARTZ MARTIN A [US]; LEY KLAUS F [US]; STOCKTON REBECCA A [US]


Application No.: US20090022801A1  Published: 22/Jan/2009

Title: Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms

Applicant/Assignee:

Application No.: 12/162990   Filing Date: 31/Jan/2007

Abstract:Methods are provided for promoting the healing of tissue of a multicellular organism. The methods can include administering a therapeutically effective amount of a polysulfonated material in a liquid mixture to reduce one or both of inflammation and cancerous cell growth. The methods may alternatively or additionally include internally administering a therapeutically effective amount of a polysulfonated material associated with a solid material to reduce one or both of inflammation and cancerous cell growth. Compositions for healing the tissue of a multicellular organism are provided that can include a sulfonated material in a liquid mixture, as well as solid particles.

Priority: US20060764033P Applic. Date: 2006-01-31; WO2007US02780 Applic. Date: 2007-01-31

Inventor: VACHON DAVID [US]


Application No.: US20090022819A1  Published: 22/Jan/2009

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR THE TREATMENT OF DRY SKIN

Applicant/Assignee: L'OREAL

Application No.: 12/175072   Filing Date: 17/Jul/2008

Abstract:Dryness of keratin materials, in particular dryness of the skin, and especially disorders associated with dry and/or hyposeborrheic skin are treated by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: FR20070056531 Applic. Date: 2007-07-17; US20070929966P Applic. Date: 2007-07-19

Inventor: GUENICHE AUDREY [FR]; BRETON LIONEL [FR]


Application No.: US20090023628A1  Published: 22/Jan/2009

Title: Cosmetic Composition and a Process for Preparing This Cosmetic Composition and a Cosmetic Product

Applicant/Assignee:

Application No.: 11/794428   Filing Date: 28/Dec/2005

Abstract:The present invention relates to a cosmetic composition comprising: a wetting system that comprises at least glycerin in an amount ranging from 8.0% to 10% by weight, based on the total weight of the composition

an emollient system that comprises at least cetyl lactate and Shea butter

an emulsifying system that comprises at least steareth-2 and steareth-21

an oiliness adsorbing system that comprises at least nylon 12

and a silicone system that comprises at least cyclomethicone and cyclomethicone and dimethicone crosspolymer. This multifunctional cosmetic composition exhibits rapid absorption, properties of differentiated softness, smoothness and intensive and prolonged hydration when applied to the skin. Further, the present invention relates to a process of preparing the referred-to cosmetic composition and to a cosmetic product that comprises said composition.

Priority: BR2004PI05956 Applic. Date: 2004-12-29; WO2005BR00262 Applic. Date: 2005-12-28

Inventor: SILVA LUCIANA VILLA NOVA [BR]; SILVA ALEXANDRE ROBERTO [BR]; BRAZ THIAGO [BR]


Application No.: US20090023813A1  Published: 22/Jan/2009

Title: Diphenyl Urea Derivatives

Applicant/Assignee: ARPIDA AG

Application No.: 12/097191   Filing Date: 08/Dec/2006

Abstract:The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Priority: WO2005EP13345 Applic. Date: 2005-12-13; WO2006EP11794 Applic. Date: 2006-12-08

Inventor: LOEWE RALF [CH]; LOCIURO SERGIO [CH]; HAWSER STEPHEN [FR]; SCHMITT LAURENT [FR]


Application No.: US20090028805A1  Published: 29/Jan/2009

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS COMPRISING ANTI-REDNESS AGENTS

Applicant/Assignee: L'OREAL

Application No.: 12/175108   Filing Date: 17/Jul/2008

Abstract:Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: FR20070056532 Applic. Date: 2007-07-17; US20070935007P Applic. Date: 2007-07-20

Inventor: GUENICHE AUDREY [FR]; BRETON LIONEL [FR]


Application No.: US20090028817A1  Published: 29/Jan/2009

Title: Compositions and methods for soft tissue augmentation

Applicant/Assignee:

Application No.: 12/220420   Filing Date: 24/Jul/2008

Abstract:The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.

Priority: US20070962289P Applic. Date: 2007-07-27

Inventor: NIKLASON LAURA [US]; LI YULING [US]; BLUM JULIANA [US]; DAHL SHANNON [US]; ERICKSON GEOFFREY [US]; ZEIGLER FRANK [US]


Application No.: US20090028826A1  Published: 29/Jan/2009

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR REDUCING BAGS AND/OR DARK CIRCLES AROUND THE EYES

Applicant/Assignee: L'OREAL

Application No.: 12/175119   Filing Date: 17/Jul/2008

Abstract:Bags and/or dark circles around the eyes of individuals afflicted therewith are reduced by administering to such individuals thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: FR20070056535 Applic. Date: 2007-07-17; US20070929970P Applic. Date: 2007-07-19

Inventor: BRETON LIONEL [FR]; GUENICHE AUDREY [FR]


Application No.: US20090028855A1  Published: 29/Jan/2009

Title: INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY

Applicant/Assignee: UNIVERSITY OF SOUTH FLORIDA

Application No.: 12/172831   Filing Date: 14/Jul/2008

Abstract:The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.

Priority: US20070949365P Applic. Date: 2007-07-12

Inventor: CHENG JIN Q [US]; SUN MEI [US]; SEBTI SAID M [US]


Application No.: US20090028897A1  Published: 29/Jan/2009

Title: COSMETIC USE OF AN ACTIVE AGENT CAPABLE OF STIMULATING TENSIN 1 EXPRESSION

Applicant/Assignee: CHANEL PARFUMS BEAUTE

Application No.: 12/128891   Filing Date: 29/May/2008

Abstract:A cosmetic skincare process intended to prevent and/or treat at least one cutaneous sign of aging, includes the topical application to the skin of a composition containing at least one active agent capable of stimulating tensin 1 expression. The cosmetic use of an active agent capable of stimulating tensin 1 expression, for preventing and/or treating at least one cutaneous sign of aging, an extract of elemi or of Canarium indicum L. or of Canarium luzonicum or of Canarium commune and a cosmetic composition containing the extract are also disclosed.

Priority: FR20070003790 Applic. Date: 2007-05-29; US20070941730P Applic. Date: 2007-06-04

Inventor: MAESTRO YANNICK [FR]; SAINTIGNY GAELLE [FR]; BERNARD FRANCOIS XAVIER [FR]


Application No.: US20090028929A1  Published: 29/Jan/2009

Title: Transdermal Patch

Applicant/Assignee: BOUTY S.P.A

Application No.: 11/886705   Filing Date: 22/Sep/2006

Abstract:A transdermal patch suitable for the administration of nitroglycerin.

Priority: IT2005MI00477 Applic. Date: 2005-03-23; WO2006EP60930 Applic. Date: 2006-03-22

Inventor: STEFANELLI PAOLA [IT]; COMUZIO SERGIO [IT]


Application No.: US20090028969A1  Published: 29/Jan/2009

Title: Compostion for treating skin

Applicant/Assignee:

Application No.: 12/229621   Filing Date: 26/Aug/2008

Abstract:A combination comprising verbascoside and luteolin, and its use in a cosmetic or pharmaceutical composition for pigmentation modulation.

Priority: EP20060290343 Applic. Date: 2006-02-28; WO2007EP01459 Applic. Date: 2007-02-21

Inventor: SENE GERARD [FR]; LOISEAU ALAIN [FR]; PETIT VIRGINIE [FR]; THERON ERIC [FR]; SEGOND CAROLINE [FR]


Application No.: US20090029902A1  Published: 29/Jan/2009

Title: PEPTIDES FOR BINDING CALCIUM CARBONATES AND METHODS OF USE

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/828539   Filing Date: 26/Jul/2007

Abstract:Combinatorially generated peptides are provided that have binding affinity for calcium carbonates. The peptides may be used to deliver benefit agents to various calcium carbonate surfaces.

Priority:

Inventor: CUNNINGHAM SCOTT D [US]; ITTEL STEVEN DALE [US]; O'BRIEN JOHN P [US]; ROUVIERE PIERRE E [US]


Application No.: US20090029992A1  Published: 29/Jan/2009

Title: SUBSTITUTED PYRAZOLE COMPOUNDS

Applicant/Assignee:

Application No.: 12/137355   Filing Date: 11/Jun/2008

Abstract:Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

Priority: US20070934062P Applic. Date: 2007-06-11; US20070990475P Applic. Date: 2007-11-27

Inventor: AGOSTON GREGORY E [US]; TRESTON ANTHONY M [US]; LADOUCEUR GAETAN [US]; SUWANDI LITA [US]


Application No.: US20090035235A1  Published: 05/Feb/2009

Title: Cosmetic composition for combating the cutaneous consequences of pollution

Applicant/Assignee:

Application No.: 11/918860   Filing Date: 21/Apr/2006

Abstract:The invention relates to the use of the extracts of plants of the genus Lapsana and of the species Lapsana communis L (Asteraceae) in particular. Said extracts are preferably obtained by maceration in a hydroglycolic mixture, and are used in cosmetic or dermopharmaceutical preparations for their skin-protective and radical-resistant properties. The actions of such preparations produce anti-ageing and anti-wrinkle effects, and protect the basic constituents of the cutaneous structure from the harsh effects of oxygen free radicals while prolonging the skin's suppleness and protective function. Said compositions supply protective cellular action against the deleterious effects of free radicals and those of enzymes such as elastase and hyaluronidase.

Priority: FR20050051037 Applic. Date: 2005-04-22; WO2006FR00896 Applic. Date: 2006-04-21

Inventor: COURTIN OLIVIER [FR]


Application No.: US20090035236A1  Published: 05/Feb/2009

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent

Applicant/Assignee:

Application No.: 12/127382   Filing Date: 27/May/2008

Abstract:An emulsion cosmetic composition comprising at least one resveratrol derivative, an aqueous phase, and an oil phase having at and at least one oil phase structuring agent, and a method for preparing emulsions capable of delivering active resveratrol to the skin.

Priority: US20070952874P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H [US]; MOHAMMADI FATEMEH [US]; QU LISA [US]; CZARNOTA ANNA [US]; WAMMONE THOMAS [US]; DECLERCQ LIEVE [BE]; ZECCHINO JULIUS R [US]


Application No.: US20090035237A1  Published: 05/Feb/2009

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant

Applicant/Assignee:

Application No.: 12/127414   Filing Date: 27/May/2008

Abstract:An emulsion cosmetic composition comprising at least one resveratrol derivative, an aqueous phase, and an oil phase, having at least one silicone surfactant, and a method for preparing emulsions capable of delivering active resveratrol to the skin.

Priority: US20070952878P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H [US]; MOHAMMADI FATEMEH [US]; QU LISA [US]; CZARNOTA ANNA [US]; MAMMONE THOMAS [US]; DECLERCQ LIEVE [BE]; ZECCHINO JULIUS R [US]


Application No.: US20090035240A1  Published: 05/Feb/2009

Title: Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent

Applicant/Assignee:

Application No.: 12/127399   Filing Date: 27/May/2008

Abstract:An aqueous based cosmetic composition comprising at least one resveratrol derivative and a water phase containing at least one aqueous phase structuring agent

or an emulsion composition comprising at least one water phase, at least one oil phase containing at least one nonvolatile silicone, and at least one resveratrol derivative.

Priority: US20070952877P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H [US]; MOHAMMADI FATEMEH [US]; QU LISA [US]; CZARNOTA ANNA [US]; MAMMONE THOMAS [US]; DECLERCO LIEVE [BE]; ZECCHINO JULIUS R [US]


Application No.: US20090035242A1  Published: 05/Feb/2009

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone

Applicant/Assignee:

Application No.: 12/127439   Filing Date: 27/May/2008

Abstract:An emulsion cosmetic composition comprising at least one resveratrol derivative, a water phase, and an oil phase containing at least one linear or branched volatile or near volatile silicone and a method for delivering active resveratrol to the skin.

Priority: US20070952881P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H [US]; MOHAMMADI FATEMEH [US]; QU LISA [US]; CZARNOTA ANNA [US]; MAMMONE THOMAS [US]; DECLERCQ LIEVE [BE]; ZECCHINO JULIUS R [US]


Application No.: US20090035247A1  Published: 05/Feb/2009

Title: METHOD OF STABILIZING A POLYSILOXANE EMULSION AND COMPOSITIONS CONTAINING STABILIZED EMULSIONS

Applicant/Assignee:

Application No.: 11/831858   Filing Date: 31/Jul/2007

Abstract:A method of stabilizing an emulsion containing a polysiloxane and one or more surfactants comprising adding an effective amount of dispersion containing a DADMAC/acrylamide copolymer and one or more sulfate salts into said emulsion is disclosed. An emulsion/cosmetically acceptable emulsion comprising a polysiloxane, at least one surfactant, and a dispersion containing DADMAC/acrylamide copolymer and one or more sulfate salts is also disclosed.

Priority:

Inventor: GABELNICK STEPHANIE E [US]; HOSOKAWA MINORU [JP]; YOKOMAKU ATSUSHI [JP]; KASHIWAI TOSHIYUKI [JP]


Application No.: US20090035261A1  Published: 05/Feb/2009

Title: IL-17 homologous polypeptides and therapeutic uses thereof

Applicant/Assignee:

Application No.: 12/214762   Filing Date: 19/Jun/2008

Abstract:The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hosT-cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Priority: US2003-458573 Applic. Date: 2003-06-10; US2001-874503 Applic. Date: 2001-06-05; US2001-816744 Applic. Date: 2001-03-22; WO2001US06520 Applic. Date: 2001-02-28; US2000-747259 Applic. Date: 2000-12-20; WO2000US23328 Applic. Date: 2000-08-24; US20000191007P Applic. Date: 2000-03-21

Inventor: CHEN JIAN [US]; FILVAROFF ELLEN [US]; FONG SHERMAN [US]; GODDARD AUDREY [US]; GODOWSKI PAUL [US]; GRIMALDI J CHRISTOPHER [US]; GUMEY AUSTIN [US]; LI HANZHONG [US]; HILLAN KENNETH [US]; HYMOWITZ SARAH G [US]; TUMAS DANIEL [US]; STAROVASNIK MELISSA A [US]; VANLOOKEREN MENNO [US]; VANDLEN RICHARD [US]; WATANABE COLIN [US]; WILLIAMS P MICKEY [US]; WOOD WILLIAM I [US]; YANSURA DANIEL [US]


Application No.: US20090035274A1  Published: 05/Feb/2009

Title: TREATMENT AND/OR PREVENTION OF CANCER AND/OR ARTHRITIS

Applicant/Assignee: LABORATOIRES SERONO SA

Application No.: 11/912432   Filing Date: 20/Apr/2006

Abstract:The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.

Priority: EP20050103402 Applic. Date: 2005-04-26; WO2004GB04544 Applic. Date: 2004-10-27; US20050681731P Applic. Date: 2005-05-17; WO2006EP61710 Applic. Date: 2006-04-20

Inventor: POWER CHRISTINE [FR]; YORKE-SMITH MELANIE [GB]


Application No.: US20090035294A1  Published: 05/Feb/2009

Title: LIPOPOLYSACCHARIDE FRACTIONS OF VITREOSCILLA FILIFORMIS USEFUL FOR STIMULATING THE SYNTHESIS OF ANTI-MICROBIAL PEPTIDES OF THE SKIN

Applicant/Assignee: L'OREAL

Application No.: 12/055975   Filing Date: 26/Mar/2008

Abstract:Specific fractions of Vitreoscilla filiformis comprising its Lipid A are useful for stimulating the synthesis of anti-microbial peptides of the skin.

Priority: FR20070054039 Applic. Date: 2007-03-26; US20070907507P Applic. Date: 2007-04-05

Inventor: MAHE YANN [FR]; MARTIN RICHARD [FR]


Application No.: US20090035313A1  Published: 05/Feb/2009

Title: Compounds

Applicant/Assignee: PFIZER INC

Application No.: 10/564693   Filing Date: 13/Jul/2004

Abstract:This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Priority: GB20030017498 Applic. Date: 2003-07-25; WO2004IB02380 Applic. Date: 2004-07-13

Inventor: BARBER CHRISTOHPER GORDON [GB]; BUNNAGE MARK EDWARD [GB]; HARVEY JOHN WILSON [GB]; MATHIAS JOHN PAUL [GB]


Application No.: US20090035365A1  Published: 05/Feb/2009

Title: Density Controlled Capsule Particles and Methods of Making the Same

Applicant/Assignee:

Application No.: 11/830367   Filing Date: 30/Jul/2007

Abstract:The present invention discloses density controlled capsule particle and methods for making the same for use in a wide range of consumer and personal care products.

Priority:

Inventor: POPPLEWELL LEWIS MICHAEL [US]; LEI YABIN [US]


Application No.: US20090035392A1  Published: 05/Feb/2009

Title: User-adjustable treatment methods, systems and compositions for treating acne

Applicant/Assignee:

Application No.: 11/450881   Filing Date: 09/Jun/2006

Abstract:Methods, apparatus, systems and the like for treating acne vulgaris that improves treatment effectiveness and/or reduces bothersome side effects associated with the ingredients used. The present Methods, apparatus, systems, etc., also provide topical compositions of benzoyl peroxide and/or other anti-acne agents that are useful for treating acne vulgaris and may be used simultaneously or sequentially in a user-adjustable ratio of two or more such compositions, or other compositions as desired such as cleansers or lotions.

Priority: US20050732785P Applic. Date: 2005-11-01

Inventor: WILKINSON RANDALL [US]


Application No.: US20090035855A1  Published: 05/Feb/2009

Title: THREE-DIMENSIONAL RECONSTITUTED EXTRACELLULAR MATRICES AS SCAFFOLDS FOR TISSUE ENGINEERING

Applicant/Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Application No.: 12/095486   Filing Date: 01/Dec/2006

Abstract:A biomaterial scaffold comprising: a) reconstituted extracellular matrix

and b) polyelectrolyte complex fibers

wherein the matrix and the fibers are functionally associated.

Priority: US20050741370P Applic. Date: 2005-12-01; WO2006SG00376 Applic. Date: 2006-12-01

Inventor: YING JACKIE Y [SG]; LECK KWONG JOO [SG]; WAN ANDREW C A [SG]


Application No.: US20090041680A1  Published: 12/Feb/2009

Title: Wax Foamable Vehicle and Pharmaceutical Compositions Thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 12/187840   Filing Date: 07/Aug/2008

Abstract:Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.

Priority: US20070954525P Applic. Date: 2007-08-07

Inventor: TAMARKIN DOV [IL]; KEYNAN RITA [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]


Application No.: US20090041685A1  Published: 12/Feb/2009

Title: Cosmetic Delivery System and Process for Manufacture Thereof

Applicant/Assignee:

Application No.: 11/887353   Filing Date: 13/Mar/2006

Abstract:A benefit agent delivery system for use in cosmetic or cleansing products is provided comprising a polysaccharide-zein complex, a benefit agent and a plasticiser. The delivery system enhances the stability of the benefit agent whilst providing for shear-triggered release of the benefit agent on application of a product to a substrate such as human skin. Also provided is a process for the preparation of the benefit agent delivery system.

Priority: IN2005MU00368 Applic. Date: 2005-03-30; IN2005MU00369 Applic. Date: 2005-03-30; EP20050256274 Applic. Date: 2005-10-07; WO2006EP02301 Applic. Date: 2006-03-13

Inventor: BAVISKAR RAJESH JANARDAN [IN]; KINI MRIDULA [IN]; PRADHAN RAM RAMESH [IN]; SURIANARAYANAN RAMESH [IN]


Application No.: US20090041688A1  Published: 12/Feb/2009

Title: Sunless tanning compositions comprising certain substituted polyamine compounds and methods of use

Applicant/Assignee:

Application No.: 12/220158   Filing Date: 22/Jul/2008

Abstract:The present invention is directed to cosmetic and/or dermatological compositions for enhancing the rate of tanning human skin with sunless tanning compositions and providing the added benefit of simultaneously providing protection from ultraviolet light radiation. More particularly, the present invention is directed to a sunless tanning composition comprising a sunless tanning agent, a substituted polyamine compound and a cosmetically acceptable adjuvant. Methods of use of the instant compositions are disclosed as well.

Priority: US20070962359P Applic. Date: 2007-07-27

Inventor: DUEVA-KOGANOV OLGA [US]; ZHOU XIAN-ZHI [US]; BARKER SHAUN [US]; JENNINGS JOHN [IE]


Application No.: US20090041691A1  Published: 12/Feb/2009

Title: Sun protection compositions comprising semi-crystalline polymers and hollow latex particles

Applicant/Assignee: L'OREAL

Application No.: 12/216527   Filing Date: 07/Jul/2008

Abstract:Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30 DEG C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

Priority: FR20070056322 Applic. Date: 2007-07-06; US20070929964P Applic. Date: 2007-07-19

Inventor: CANDAU DIDIER [FR]; BOUTELET KARL [FR]


Application No.: US20090041697A1  Published: 12/Feb/2009

Title: Film-Forming Compositions for Protecting Skin From Body Fluids and Articles Made Therefrom

Applicant/Assignee:

Application No.: 12/245187   Filing Date: 03/Oct/2008

Abstract:A film-forming barrier composition useful for protecting the skin from body fluids, such as urine, feces, menses. The composition includes a skin conditioning agent, a viscosity enhancing agent and an oleophilic film-forming agent. Optionally, the lotion may include a skin care ingredients for treating or maintaining skin health. The composition may be applied to the skin by suitable delivery vehicles, such as absorbent articles or components thereof, sheet materials, pads, bandages, sponges, foam pads, pumps, sprays, depending on the viscosity of the composition.

Priority: US2005-273355 Applic. Date: 2005-11-14; US2001-898880 Applic. Date: 2001-07-03

Inventor: KLOFTA THOMAS JAMES [US]; STAUDIGEL JAMES ANTHONY [US]; DECKNER GEORGE ENDEL [US]


Application No.: US20090041740A1  Published: 12/Feb/2009

Title: CANCER TREATMENT BY METABOLIC MODULATIONS

Applicant/Assignee: ENGENE, INC

Application No.: 12/017902   Filing Date: 22/Jan/2008

Abstract:The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.

Priority: US2007-983021 Applic. Date: 2007-11-05; US2003-697700 Applic. Date: 2003-10-29; US20020422365P Applic. Date: 2002-10-29

Inventor: POWNALL SCOTT [CA]; CHEUNG ANTHONY T [CA]; HSU ERIC C [CA]; DOIRON BRUNO [CA]


Application No.: US20090041779A1  Published: 12/Feb/2009

Title: Aldosterone induced elastin production

Applicant/Assignee:

Application No.: 12/157141   Filing Date: 06/Jun/2008

Abstract:Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.

Priority: US20070942305P Applic. Date: 2007-06-06

Inventor: MITTS THOMAS F [US]; HINEK ALEKSANDER [CA]


Application No.: US20090041848A1  Published: 12/Feb/2009

Title: SKIN ANTI-AGING AGENT FOR EXTERNAL USE

Applicant/Assignee: FUJIFILM CORPORATION

Application No.: 12/060392   Filing Date: 01/Apr/2008

Abstract:It is an object of the present invention to provide a skin anti-aging agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size and high permeability into skin. The present invention provides a skin anti-aging agent for external use, which comprises protein nanoparticles containing an active ingredient.

Priority: JP20070096192 Applic. Date: 2007-04-02

Inventor: AIMI MAKIKO [JP]; OGIWARA KAZUTAKA [JP]; AMANO TAKUO [JP]


Application No.: US20090041866A1  Published: 12/Feb/2009

Title: ABNORMAL PROTEIN REMOVING COMPOSITION

Applicant/Assignee:

Application No.: 12/088919   Filing Date: 20/Jul/2006

Abstract:It is an object of the present invention to efficiently remove abnormal protein produced in living tissues, especially skin, due to exposure to UV light, etc. A composition for removing abnormal protein containing one or two or more substances selected from silybin, Bletilla striata extract and Iris sanguinea extract.

Priority: JP20050289491 Applic. Date: 2005-10-03; WO2006JP314403 Applic. Date: 2006-07-20

Inventor: MIYATA SATOSHI [JP]; UMINO YUKARI [JP]


Application No.: US20090041875A1  Published: 12/Feb/2009

Title: Anti-wrinkle composition

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 11/918424   Filing Date: 12/Apr/2006

Abstract:There is provided a novel anti-wrinkle composition comprising one or more from among watercress, juniper, baizhu and coltsfoot extracts as active ingredients.

Priority: JP20050116061 Applic. Date: 2005-04-13; WO2006JP308163 Applic. Date: 2006-04-12

Inventor: TAKADA KEIKO [JP]; INOMATA SHINJI [JP]; OGURA YUKI [JP]; UMISHIO KENICHI [JP]


Application No.: US20090042766A1  Published: 12/Feb/2009

Title: Solid Textile Care Composition Comprising A Water-Soluble Polymer

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 12/246129   Filing Date: 06/Oct/2008

Abstract:A solid textile care composition having a water-soluble carrier, a water-soluble polymer, a textile care compound and a perfume. A solid textile care composition in which the water-soluble carrier is present in particulate form and has an envelope composed of the water-soluble polymer, the textile care compound and the perfume. Also textile care washing or cleaning compositions comprising the textile care composition.

Priority: DE200610016578 Applic. Date: 2006-04-06; WO2007EP52129 Applic. Date: 2007-03-07

Inventor: MAYER KONSTANZE [DE]; SCHEFFLER KARL-HEINZ [DE]; ARTIGA-GONZALEZ RENE-ANDRES [DE]; HARTH HUBERT [DE]; STURM MARIO [DE]; SEGLER TOBIAS [DE]; TIGGES DANIEL [DE]


Application No.: US20090042805A1  Published: 12/Feb/2009

Title: Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications

Applicant/Assignee:

Application No.: 11/791469   Filing Date: 24/Nov/2005

Abstract:The invention relates to peptides having a core sequence selected in the group comprising: SEQ ID No.1: VDEAD, SEQ ID No.2: LDEGD, SEQ ID No.3: VDEGD, SEQ ID No.4: VDESD, SEQ ID No.5: LDEKD, SEQ ID No.6: FDESD, SEQ ID No.7: LDEAD, application as inhibitors of caspase-2 and/or -6 activity.

Priority: US20040630249P Applic. Date: 2004-11-24; WO2005EP13976 Applic. Date: 2005-11-24

Inventor: CHAUVIER DAVID [FR]; CASIMIR RICHARD [FR]; HOEBEKE JOHAN [BE]


Application No.: US20090042844A1  Published: 12/Feb/2009

Title: 17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS

Applicant/Assignee: ENDORECHERCHE, INC

Application No.: 12/100372   Filing Date: 09/Apr/2008

Abstract:Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

Priority: US20070911434P Applic. Date: 2007-04-12; US20070911452P Applic. Date: 2007-04-12

Inventor: LABRIE FERNAND [CA]; GAUTHIER SYLVAIN [CA]; CLOUTIER JULIE [CA]; MAILHOT JOSEE [CA]; POTVIN STEEVES [CA]; DION SYLVAIN [CA]; SANCEAU JEAN-YVES [CA]


Application No.: US20090042846A1  Published: 12/Feb/2009

Title: Topical Delivery System for Phytosterols

Applicant/Assignee: BIODERM RESEARCH

Application No.: 12/210266   Filing Date: 15/Sep/2008

Abstract:This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof

Wherein, n=0, 1, 2, or 3

and R=H, -CH2OH, -CH(OH)-CH2OH, -CH(OH)-CH(OH)-CH2OH

and R1=Substituent selected from a sapogenin, steroid, or terpenoid.

Priority: US2005-161856 Applic. Date: 2005-08-19; US2008-139659 Applic. Date: 2008-06-16

Inventor: GUPTA SHYAM K [US]


Application No.: US20090042923A1  Published: 12/Feb/2009

Title: Method of Treating Tumors with Azaxanthones

Applicant/Assignee:

Application No.: 12/255141   Filing Date: 21/Oct/2008

Abstract:The use of azaxanthones for treating diseases associated with tumor cells which express one or more protein of S100 family, and in treating patients that have malignancies consisting of tumors of an epithelial or mesenchymal nature, where these compounds are effective in retarding the progression and/or metastasis of these tumors.

Priority: US2005-301930 Applic. Date: 2005-12-13

Inventor: SEMOV ALEXANDRE [CA]; PIETRZYNSKI GRZEGORZ [CA]; ALAKHOV VALERY [CA]


Application No.: US20090042950A1  Published: 12/Feb/2009

Title: TRANSDERMAL TOPICAL COMPOSITION AND ITS USES

Applicant/Assignee: TRANSPHASE LIMITED

Application No.: 11/909061   Filing Date: 22/Mar/2006

Abstract:At least one silicone is used to modify the release profile of the active compound(s) in a therapeutic composition for topical application the skin that also comprises at least one penetration enhancer and a fugitive solvent base.

Priority: GB20050006139 Applic. Date: 2005-03-24; WO2006GB01063 Applic. Date: 2006-03-22

Inventor: PANDYA ANANT K [GB]


Application No.: US20090043279A1  Published: 12/Feb/2009

Title: MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS

Applicant/Assignee:

Application No.: 12/187268   Filing Date: 06/Aug/2008

Abstract:The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.

Priority: US20070963725P Applic. Date: 2007-08-06; US20070994568P Applic. Date: 2007-09-19

Inventor: KASPAR ROGER L [US]; SPEAKER TYCHO [US]


Application No.: US20090047224A1  Published: 19/Feb/2009

Title: Cosmetic Process for Preventing or Treating the Signs of Skin Ageing or the Orange-Peel Appearance

Applicant/Assignee: L'OREAL

Application No.: 10/580230   Filing Date: 08/Nov/2004

Abstract:The present invention relates to the use of at least one compound capable of cleaving the diketone crosslinking bonds between two proteins, in a composition applied topically to the skin, as an agent for preventing or treating the signs of ageing of the skin or the orange-peel appearance. The above compound is preferably a N-hydroxy imide of formula (I). These N-hydroxy imides have inhibitory properties on the glycation of proteins and also antioxidant properties. The invention also relates to novel N-hydroxy imides included in formula (I) above.

Priority: FR20030050870 Applic. Date: 2003-11-20; FR20040008987 Applic. Date: 2004-08-19; US20040544320P Applic. Date: 2004-02-17; WO2004EP12699 Applic. Date: 2004-11-08

Inventor: DALKO MARIA [FR]; PAGEON HERVE [FR]


Application No.: US20090047227A1  Published: 19/Feb/2009

Title: Cationic Cassia Derivatives and Applications Therefor

Applicant/Assignee: LUBRIZOL ADVANCED MARTERIALS, INC

Application No.: 12/254437   Filing Date: 20/Oct/2008

Abstract:This invention relates to cationically derivatized polycalactomannans obtained from cassia tora and cassia obtusifolia and to their use in personal care, household care, and institutional care compositions.

Priority: US2007-843920 Applic. Date: 2007-08-23; US2004-874296 Applic. Date: 2004-06-18; US20030479793P Applic. Date: 2003-06-19

Inventor: LEPILLEUR CAROLE A [US]


Application No.: US20090047309A1  Published: 19/Feb/2009

Title: COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN

Applicant/Assignee:

Application No.: 11/837658   Filing Date: 13/Aug/2007

Abstract:The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.

Priority:

Inventor: MAES DANIEL H [US]; MAMMONE THOMAS [US]; GOLDGRABEN KERRI [US]


Application No.: US20090047310A1  Published: 19/Feb/2009

Title: Use of a griffonia extract, in particular griffonia simplicifolia, in a cosmetic or dermatological composition for mitigating pigmentation of skin and skin appendages

Applicant/Assignee:

Application No.: 11/921943   Filing Date: 24/May/2006

Abstract:Use of an extract of Griffonia, in particular of Griffonia simplicifolia, in a cosmetic or dermatological preparation for attenuating the pigmentation of the skin and of superficial body growths. This cosmetic or dermatological preparation may also contain any of the following products: at least one other active depigmenting product, at least one substance for filtering or blocking B and/or A ultraviolet radiation, at least one anti-inflammatory product, at least one agent encouraging flaking. It contains from 0.05 to 20% by weight of an extract of Griffonia simplicifolia.

Priority: FR20050005958 Applic. Date: 2005-06-13; WO2006FR01181 Applic. Date: 2006-05-24

Inventor: MEYBECK ALAIN [FR]


Application No.: US20090047316A1  Published: 19/Feb/2009

Title: Porous particles loaded with cosmetically or pharmaceutically active compounds

Applicant/Assignee: L'OREAL

Application No.: 12/285297   Filing Date: 01/Oct/2008

Abstract:Individualized porous particles have a volume-average diameter of less than or equal to 10 mum and a specific surface area of greater than or equal to 1 m2/g, and include at least one cosmetically or pharmaceutically active compound present at least inside the particles.

Priority: FR20030007747 Applic. Date: 2003-06-26; US2004-876527 Applic. Date: 2004-06-28; US20030487245P Applic. Date: 2003-07-16

Inventor: SIMONNET JEAN-THIERRY [FR]; BIATRY BRUNO [FR]; SAINT-LEGER DIDIER [FR]


Application No.: US20090047330A1  Published: 19/Feb/2009

Title: Oral fast dissolving films for erectile dysfunction bioactive agents

Applicant/Assignee:

Application No.: 12/228702   Filing Date: 09/Oct/2008

Abstract:A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweeteners and specified amounts of bioactive agents, for erectile dysfunction. A flexible film dosage form containing sildenafil citrate, tadalafil or Vardenafil is presented. The film system is enabled to be used in various applications such as oral, mucosal and external environments.

Priority: US20070965047P Applic. Date: 2007-08-17; US20070964950P Applic. Date: 2007-08-17; US20070965022P Applic. Date: 2007-08-17

Inventor: BANGALORE RAMESH [US]


Application No.: US20090047350A1  Published: 19/Feb/2009

Title: Perforated water soluble polymer based edible films

Applicant/Assignee:

Application No.: 12/228703   Filing Date: 14/Aug/2008

Abstract:A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweetners and specified amounts of bioactive agents preferably having perforations in the body of the dosage form enabling it to disperse/dissolve rapidly upon application by the subject. A flexible film dosage form to accommodate higher drug loads without compromising the fast dispersing/dissolving characteristics is presented. The perforated film system is enabled to be used in various applications such as oral, mucosal and external environments. The perforated film dosage form therefore, additionally allows the usage of polymers that would otherwise have not been used due to insolubility or limited solubility in water.

Priority: US20070965043P Applic. Date: 2007-08-17; US20070965023P Applic. Date: 2007-08-17

Inventor: BANGALORE RAMESH [US]


Application No.: US20090047371A1  Published: 19/Feb/2009

Title: PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

Applicant/Assignee: SAFI INVESTMENT HOLDING AG

Application No.: 12/067291   Filing Date: 21/Feb/2006

Abstract:The present invention concerns a pharmaceutical composition containing curcumin and resveratrol and its application in the medical field. In particular, the composition according to the invention can be advantageously employed for preventing ageing and vascular diseases, for the treatment and the prophylaxis of cancers as prostate carcinoma, of skin diseases as psoriasis, and of the piliferous system as hair loss.

Priority: IT2005FI00031 Applic. Date: 2005-02-21; WO2006IT00093 Applic. Date: 2006-02-21

Inventor: TURINI DAMIANO [IT]; COCCOLONI STEFAN [IT]


Application No.: US20090047439A1  Published: 19/Feb/2009

Title: METHOD AND APPARATUS FOR MANUFACTURING POROUS ARTICLES

Applicant/Assignee:

Application No.: 12/189658   Filing Date: 11/Aug/2008

Abstract:A method for producing porous materials which comprises directing a plasma stream containing particles of a base material in liquid or solid/liquid form onto a substrate under controlled conditions in which the particles spot weld to the substrate or to one another without full fusion, and establishing relative movement between the plasma stream and the substrate whereby the material is deposited as a porous structure of desired porosity and shape.

Priority: US20070956374P Applic. Date: 2007-08-16

Inventor: WITHERS JAMES C [US]; SHAPOVALOV VLADIMIR [US]


Application No.: US20090048153A1  Published: 19/Feb/2009

Title: COMPOSITION FOR TREATING SULFUR MUSTARD TOXICITY AND METHODS OF USING SAME

Applicant/Assignee: UNIVERSITY OF MARYLAND, BALTIMORE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 11/720283   Filing Date: 02/Dec/2005

Abstract:One embodiment of the present invention provides a composition, comprising, in amounts effective to treat sulfur mustard or half sulfur mustard induced toxicity or skin damage: an agent that inhibits alkylation of -SH and >NH protein groups

an agent that reduces -SS- to SH

a scavenger of reactive oxygen species

a substrate that maintains tissue reduction-oxidation status

an agent that protects against invading inflammatory cells and associated oxidative stress

an antagonist of prostaglandin synthesis

and an agent that induces tissue regeneration. Methods of using the composition are also provided.

Priority: US20040632834P Applic. Date: 2004-12-03; WO2005US43341 Applic. Date: 2005-12-02

Inventor: VARMA SHAMBHU D [US]; PETRALI JOHN [US]


Application No.: US20090048211A1  Published: 19/Feb/2009

Title: EXTERNAL PREPARATION COMPOSITION

Applicant/Assignee: LION CORPORATION

Application No.: 12/257853   Filing Date: 24/Oct/2008

Abstract:An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined

and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.

Priority: US2005-522032 Applic. Date: 2005-01-21; WO2002JP07549 Applic. Date: 2002-07-25

Inventor: KAMBAYASHI HIROAKI [JP]; KONTA HIROSHI [JP]


Application No.: US20090048267A1  Published: 19/Feb/2009

Title: MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 12/118992   Filing Date: 12/May/2008

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1, to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030768 Applic. Date: 2004-12-24; US2005-275225 Applic. Date: 2005-12-20

Inventor: PARK JOHN EDWARD [DE]; CHAUDHARY NVEED [GB]; LEHMANN-LINTZ THORSTEN [DE]; HECKEL ARMIN [DE]; ROTH GERALD JUERGEN [DE]; KLEY JOERG [DE]; BRANDL TRIXI [CH]; DAHMANN GEORG [DE]; GRAUERT MATTHIAS [DE]


Application No.: US20090048338A1  Published: 19/Feb/2009

Title: BIOLOGICALLY ACTIVE OILS

Applicant/Assignee:

Application No.: 12/125024   Filing Date: 21/May/2008

Abstract:A process for the production of fats or oils and their extracts containing biologically active chemical compounds from a lipid substrate, the process comprising: a) inoculation of a lipid substrate with fungally derived lipolytic enzymes

b) incubating the inoculated substrate for a period of between about 7-120 days at a temperature of between about 435 DEG C., at a humidity of between about 75-100%, and c) processing said substrate mixture to obtain a biologically active fat or oil.

Priority: AU20030902823 Applic. Date: 2003-06-04; US2005-559599 Applic. Date: 2005-12-02; WO2004AU00745 Applic. Date: 2004-06-04

Inventor: TURNER ATHOL GILLIES [AU]


Application No.: US20090048493A1  Published: 19/Feb/2009

Title: Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data

Applicant/Assignee:

Application No.: 11/840357   Filing Date: 17/Aug/2007

Abstract:A method for integrating and managing data is provided that includes interacting with an end user via a health and entertainment device, the device including: an accelerometer that is operable to track activity data by the user and a music module operable to play music for the user. The device further includes a memory and a processor operable to convert data from the accelerometer into one or more metrics based on data received from the memory.

Priority:

Inventor: JAMES TERRY L [US]; JAMES GRANT K [US]


Application No.: US20090048567A1  Published: 19/Feb/2009

Title: PATCH

Applicant/Assignee:

Application No.: 12/093913   Filing Date: 20/Nov/2006

Abstract:The invention provides a patch device adapted for use in the transdermal administration to a patient of a composition including one or more pharmaceutically, cosmetically, pesticidally, prophylactically, and nutritionally active substance, the patch consisting of a layered construct adapted to be adhered to the skin of a patient and defining a cavity for receiving one or more disruptable containers of the composition or components of the composition to be administered between a proximal layer and a distal layer thereof, which proximal layer is adapted in use to be located in intimate contact with the skin of the patient and which distal layer is in use disposed on the outer side thereof, wherein the proximal layer is partially permeable to that composition, so that in use the integrity of the one or more containers may be disrupted thereby causing the composition to be disposed in the cavity and permeate from there through the proximal layer to be absorbed through the skin into the body of the patient. The invention further provides a method of applying an irritant to the skin of a user.

Priority: GB20050024121 Applic. Date: 2005-11-26; WO2006ZA00131 Applic. Date: 2006-11-20

Inventor: VAN ROOYEN QUINTON [NA]; VAN ROOYEN CHRISTINA [NA]; JONES JOHANNES [NA]; LE ROUX ABRAHAM JOSUA [ZA]; POWELL CORNELIUS JOHANNES [NA]


Application No.: US20090051787A1  Published: 26/Feb/2009

Title: APPARATUS AND METHOD FOR PHOTOGRAPHING IMAGE USING DIGITAL CAMERA CAPABLE OF PROVIDING PREVIEW IMAGES

Applicant/Assignee:

Application No.: 12/197566   Filing Date: 25/Aug/2008

Abstract:Disclosed is an apparatus for photographing an image using a digital camera capable of providing a preview image, including: an image sensor for capturing an image of a subject

a first image signal processor for processing at least one captured image as a sequent image in order to display the captured image as a preview image on a display window and detecting a face area from the captured image

a buffer for storing the image including at least one detected face area

a capture button for capturing a still image during outputting the sequent image as the preview image on the display window

a second image signal processor for processing the captured still image using the capture button

a controller for controlling to store the captured still image and information related on the face area detected from the first image signal processor prior to the input of the capture button

and a memory for storing the processed still image together with the information related on the detected face area.

Priority: KR20070085125 Applic. Date: 2007-08-23

Inventor: YOON JE-HAN [KR]; KIM HYUN-SOO [KR]; LEE JI-HYO [KR]


Application No.: US20090053290A1  Published: 26/Feb/2009

Title: TRANSDERMAL DRUG DELIVERY COMPOSITIONS AND TOPICAL COMPOSITIONS FOR APPLICATION ON THE SKIN

Applicant/Assignee:

Application No.: 12/281768   Filing Date: 08/Mar/2007

Abstract:Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX(R), anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

Priority: US20070878886P Applic. Date: 2007-01-03; US20060796007P Applic. Date: 2006-04-28; US20060781951P Applic. Date: 2006-03-08; US20060781950P Applic. Date: 2006-03-08; US20060781925P Applic. Date: 2006-03-08; US20060801349P Applic. Date: 2006-05-18; US20060781952P Applic. Date: 2006-03-08; WO2007US06037 Applic. Date: 2007-03-08

Inventor: SAND BRUCE J [US]; BABICH MICHAEL [US]; HAGHIGHI ALI ZENDEDEL [US]


Application No.: US20090053301A1  Published: 26/Feb/2009

Title: SILICONE VESICLES CONTAINING ACTIVES

Applicant/Assignee:

Application No.: 12/279352   Filing Date: 12/Jan/2007

Abstract:A process is disclosed for preparing a hydrophobic active loaded vesicle composition by admixing a hydrophobic active to a pre-formed silicone vesicle dispersion. The silicone vesicle compositions are useful in a variety of personal and healthcare compositions.

Priority: US20060777665P Applic. Date: 2006-02-28; WO2007US00833 Applic. Date: 2007-01-12

Inventor: LIN SHAOW [US]; THOMPSON JAMES [US]


Application No.: US20090054349A1  Published: 26/Feb/2009

Title: Peptides for Promoting Hair Growth and Improving Wrinkle and Cosmetic Compositions Comprising the same

Applicant/Assignee:

Application No.: 12/083969   Filing Date: 24/Oct/2006

Abstract:The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin beta-4 (Tbeta4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tbeta4 and its biological activity is almost identical to natural-occurring Tbeta4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tbeta4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin beta-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics. Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.

Priority: KR20050100390 Applic. Date: 2005-10-24; WO2006KR04352 Applic. Date: 2006-10-24

Inventor: CHUNG YONG JI [KR]; KIM YOUNG DEUG [KR]; KIM CHUNG RYUL [KR]


Application No.: US20090054368A1  Published: 26/Feb/2009

Title: Substituted gemini surfactant compounds

Applicant/Assignee: UNIVERSITY OF SASKATCHEWAN

Application No.: 12/215963   Filing Date: 01/Jul/2008

Abstract:The compositions, systems, and methods relate to substituted and asymmetric gemini surfactants for use in delivering biologically active agents, such as nucleic acids, to a subject. The described compositions, systems, and methods are useful for gene therapy.

Priority: US20070958563P Applic. Date: 2007-07-06

Inventor: WETTIG SHAWN [CA]; VERRALL RONALD ERNEST [CA]; FOLDVARI MARIANNA [CA]


Application No.: US20090054376A1  Published: 26/Feb/2009

Title: BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES

Applicant/Assignee: PHARMOS CORPORATION

Application No.: 11/915825   Filing Date: 31/May/2006

Abstract:The present invention relates to novel benzofuran compounds, to pharmaceutical compositions that include such compounds, and to methods of use thereof. Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful as analgesic, neuroprotective, immunomodulatory and anti-inflammatory agents.

Priority: US20050685374P Applic. Date: 2005-05-31; WO2006IL00641 Applic. Date: 2006-05-31

Inventor: YACOVAN AVIHAI [IL]; GRYNSZPAN FLAVIO [IL]; AIZIKOVICH ALEXANDER [IL]; BRODY MARCUS STEPHEN [US]; BAR-JOSEPH AVI [IL]; MEILIN SIGAL [IL]


Application No.: US20090054382A1  Published: 26/Feb/2009

Title: COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS

Applicant/Assignee:

Application No.: 12/090798   Filing Date: 19/Oct/2006

Abstract:Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV ("PDE-IV"), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), beta2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

Priority: IN2005DE02793 Applic. Date: 2005-10-19; WO2006IB02931 Applic. Date: 2006-10-19

Inventor: RAY ABHIJIT [IN]; DASTIDAR SUNANDA G [IN]; SHIRUMALLA RAJKUMAR [IN]; GUPTA SUMAN [IN]


Application No.: US20090054956A1  Published: 26/Feb/2009

Title: MULTIPLE WAVELENGTH LASER WORKSTATION

Applicant/Assignee: CYNOSURE, INC

Application No.: 12/191163   Filing Date: 13/Aug/2008

Abstract:Lasers capable of lasing at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium. Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized. In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy.

Priority: US2005-035680 Applic. Date: 2005-01-14

Inventor: SIERRA RAFAEL ARMANDO [US]; KOSCHMANN ERIC CALVIN [US]; DAY JOSEPH M [US]; SHERR EVAN ANDREW [US]; BOLL JAMES HENRY [US]


Application No.: US20090060849A1  Published: 05/Mar/2009

Title: Personal care compositions comprising certain dye-polymer complexes

Applicant/Assignee:

Application No.: 12/231579   Filing Date: 04/Sep/2008

Abstract:The present invention relates to personal care compositions comprising certain dye-polymer complexes. Additionally, methods for coloration of personal care compositions using said dye-polymer complexes are disclosed.

Priority: US20070967534P Applic. Date: 2007-09-05

Inventor: SONG ZHIQIANG [US]; JAYNES BINGHAM SCOTT [US]; LUPIA JOSEPH ANTHONY [US]; ZHOU XIAN-ZHI [US]


Application No.: US20090060852A1  Published: 05/Mar/2009

Title: Compounds, Formulations and Methods for Reducing Skin Wrinkles, Creasing and Sagging

Applicant/Assignee:

Application No.: 12/180790   Filing Date: 28/Jul/2008

Abstract:Methods, compounds, and topical formulations for reduction of skin sagging, creasing and/or wrinkling are disclosed. The methods comprise topically applying a composition comprising an alpha2 adrenergic receptor agonist. Amelioration of skin sagging, creasing and/or wrinkling begins within minutes after topical application of a disclosed composition. A single application can significantly reduce skin sagging, creasing and/or wrinkling for at least about 8 hours.

Priority: US20070952298P Applic. Date: 2007-07-27

Inventor: DEJOVIN JACK [US]; DEJOVIN ISABELLE JEAN [US]


Application No.: US20090060873A1  Published: 05/Mar/2009

Title: Novel synthetic triterpenoids and methods of use in the treatment and prevention of multiple scleroris

Applicant/Assignee: REATA PHARMACEUTICALS, INC

Application No.: 12/151425   Filing Date: 05/May/2008

Abstract:The present invention overcomes limitations of the prior art by providing new compounds and methods for the treatment of conditions, such as neurodegenerative diseases (e.g., multiple sclerosis), psychiatric disorders (e.g., psychosis, bipolar disorder, depression, neuropathic pain), conditions involving CNS-mediated chronic pain, spinal cord injuries, and other diseases or injuries.

Priority: US20070916273P Applic. Date: 2007-05-04

Inventor: SPORN MICHAEL B [US]; LIBY KAREN T [US]; GRIBBLE GORDON W [US]; HONDA TADASHI [US]; LETTERIO JOHN [US]


Application No.: US20090060906A1  Published: 05/Mar/2009

Title: Anti-IL-13 antibody formulations and uses thereof

Applicant/Assignee: WYETH

Application No.: 12/008129   Filing Date: 09/Jan/2008

Abstract:Formulations suitable for treatment of disorders associated with undesirable expression or activity of IL-13 are provided.

Priority: US20070879500P Applic. Date: 2007-01-09

Inventor: BARRY ANTHONY B [US]; CROWLEY THOMAS J [US]; DIXON DANIEL A [US]; SOLEY ERIN CHRISTINE [US]


Application No.: US20090060933A1  Published: 05/Mar/2009

Title: PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME

Applicant/Assignee:

Application No.: 11/933027   Filing Date: 31/Oct/2007

Abstract:The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.

Priority: US2004-498714 Applic. Date: 2004-06-14

Inventor: ESTELL DAVID A [US]; HARDING FIONA A [US]


Application No.: US20090060962A1  Published: 05/Mar/2009

Title: COSMETIC USE OF BIFIDOBACTERIUM SPECIES LYSATE FOR THE TREATMENT OF DRYNESS

Applicant/Assignee: L'OREAL

Application No.: 12/200426   Filing Date: 28/Aug/2008

Abstract:Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.

Priority: FR20070057348 Applic. Date: 2007-09-04; US20070973541P Applic. Date: 2007-09-19

Inventor: CASTIEL ISABELLE [FR]; BRETON LIONEL [FR]; GUENICHE AUDREY [FR]


Application No.: US20090060979A1  Published: 05/Mar/2009

Title: CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS

Applicant/Assignee:

Application No.: 12/202939   Filing Date: 02/Sep/2008

Abstract:The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.

Priority: US20070968917P Applic. Date: 2007-08-30

Inventor: BEZWADA RAO S [US]


Application No.: US20090061030A1  Published: 05/Mar/2009

Title: COSMETIC MATERIAL CONTAINING SWEE PEA EXTRACT

Applicant/Assignee: FANCL CORPORATION

Application No.: 11/910237   Filing Date: 14/Mar/2006

Abstract:A cosmetic material, cell growth promoting agent, elastase activity inhibiting agent and anti-aging agent containing sweet pea extract, formulated with the aim of preventing or slowing aging.

Priority: JP20050106563 Applic. Date: 2005-04-01; WO2006JP304966 Applic. Date: 2006-03-14

Inventor: HITOMI TAKAMASA [JP]; MATSUKUMA SHOKO [JP]


Application No.: US20090062224A1  Published: 05/Mar/2009

Title: Therapeutic use of cpg oligodeoxynucleotide for skin disease

Applicant/Assignee:

Application No.: 10/589102   Filing Date: 04/Nov/2005

Abstract:Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.

Priority: WO2005KR03717 Applic. Date: 2005-11-04; KR20040090000 Applic. Date: 2004-11-05

Inventor: KIM TAE-YOON [KR]; KIM DOO-SIK [KR]; KWON HYUNG-JOO [KR]; KIM YANG-SOON [KR]


Application No.: US20090062244A1  Published: 05/Mar/2009

Title: PHARMACEUTICAL COMPOSITION

Applicant/Assignee:

Application No.: 11/849652   Filing Date: 04/Sep/2007

Abstract:Topical composition for enhanced local and systemic delivery of poorly soluble biologically active compounds, comprises of non-volatile solvent or mixture of solvents to dissolve active component, and moisture absorbent or mixture of sorbents to prevent precipitation or crystallization of insoluble material after application

Priority:

Inventor: SCHWARZ JOSEPH [US]; WEISSPAPIR MICHAEL [US]


Application No.: US20090062371A1  Published: 05/Mar/2009

Title: ORAL PREPARATION FOR PROMOTING SYNTHESIS OF TISSUE COLLAGEN

Applicant/Assignee: KYOWA HAKKO KOGYO CO., LTD

Application No.: 12/280846   Filing Date: 23/Mar/2007

Abstract:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

Priority: JP20060079921 Applic. Date: 2006-03-23; WO2007JP55977 Applic. Date: 2007-03-23

Inventor: KAMIYA TOSHIKAZU [JP]; KAMIMURA AYAKO [JP]; KAWADA YOKO [JP]


Application No.: US20090062401A1  Published: 05/Mar/2009

Title: DECALINE-DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS

Applicant/Assignee: UNIVERSITAT DORTMUND MAX-PLANCK-GESELLSCHAFT ZUR FODERUNG DER WISSENSCHAFTEN E.V UNIVERSITAT BERN

Application No.: 11/813129   Filing Date: 28/Dec/2005

Abstract:The present invention relates to compounds having a decaline scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said decaline-derived compounds can be used for prophylaxsis and/or treatment of diabetes mellitus type I, diabetes mellitus type II, tuberculosis and other infectious diseases, proliferative diseases, cancer, neurodegenerative diseases, obesity, cognitive dysfunctions and metabolic syndromes.

Priority: EP20040031076 Applic. Date: 2004-12-31; WO2005EP14100 Applic. Date: 2005-12-28

Inventor: ODERMATT ALEX [CH]; WALDMANN HERBERT [DE]; SCHECK MICHAEL [DE]; KOCH MARCUS A [DE]


Application No.: US20090062402A1  Published: 05/Mar/2009

Title: ACTIVE SUBSTANCE COMBINATION OF LICOCHALCONE A AND PHENOXYETHANOL

Applicant/Assignee: BEIERSDORF AG

Application No.: 12/270009   Filing Date: 13/Nov/2008

Abstract:A method for the prophylaxis or treatment of inflammatory skin conditions, which method comprises applying to the skin a cosmetic or pharmaceutical preparation comprising licochalcone A and phenoxyethanol. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: DE20031056164 Applic. Date: 2003-12-02; US2004-001224 Applic. Date: 2004-12-02

Inventor: KRUSE INGE [DE]; RASCHKE THOMAS [DE]; VIETZKE JENS-PETER [DE]; ECKERT JULIA [DE]


Application No.: US20090065521A1  Published: 12/Mar/2009

Title: WET WIPES DISPENSING SYSTEM

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 12/267007   Filing Date: 07/Nov/2008

Abstract:The present disclosure relates to wet wipe dispensing systems for dispensing wet wipes capable of changing temperature upon use. In one embodiment, the dispensing system includes a wet wipe container and a lotion container that is held in assembly with the wet wipe container that contains a lotion that is kept separate from the wet wipes until the wet wipe is dispensed from the wet wipe container. The lotion includes a microencapsulated delivery vehicle that contains a temperature change agent that is capable of generating a temperature change upon contact with an aqueous solution. Once the wet wipe is dispensed from the system, an applicating device can apply the lotion to the wet wipe to facilitate contact between the temperature change agent in the microencapsulated delivery vehicle and the aqueous solution of the wet wipe.

Priority: US2006-420993 Applic. Date: 2006-05-30

Inventor: AMUNDSON JOHN DAVID [US]; ABUTO FRANK P [US]; CLARE TIMOTHY P [US]; FOLEY EDWARD JOHN [US]; WINDER ERIC MICHAEL [US]; SCHMIDT PAUL R [US]; JOSEPH WAEL R [US]; MCDONALD DUANE LYLE [US]


Application No.: US20090068119A1  Published: 12/Mar/2009

Title: Sprayable Depilatory Composition and a Method of use

Applicant/Assignee:

Application No.: 12/083329   Filing Date: 16/Oct/2006

Abstract:A sprayable depilatory composition including a depilatory agent

a surfactant present in the range 0.1% to 5.0% by weight of the composition, wherein the composition has an initial viscosity substantially less than about 7.00 Pas.

Priority: GB20050020930 Applic. Date: 2005-10-14; WO2006GB03821 Applic. Date: 2006-10-16

Inventor: CAWTHORNE LEE [GB]


Application No.: US20090068160A1  Published: 12/Mar/2009

Title: USE OF A LYSATE OF BIFIDOBACTERIUM SPECIES FOR TREATING SENSITIVE SKIN

Applicant/Assignee: L'OREAL

Application No.: 12/200417   Filing Date: 28/Aug/2008

Abstract:Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.

Priority: FR20070057352 Applic. Date: 2007-09-04; US20070973534P Applic. Date: 2007-09-19

Inventor: CASTIEL ISABELLE [FR]; BRETON LIONEL [FR]; GUENICHE AUDREY [FR]


Application No.: US20090068278A1  Published: 12/Mar/2009

Title: USE OF FREE RADICAL SCAVENGERS FOR PROTECTING AND TREATING SKIN AND HAIR DAMAGES CAUSED BY CHEMOTHERAPY

Applicant/Assignee:

Application No.: 11/913501   Filing Date: 04/May/2006

Abstract:The present invention relates to the use of one or more free radical scavengers as prophylactically or therapeutically effective substances and microparticles having an average particle size ranging from 5 to 200 mum for the preparation of a topical pharmaceutical composition for the protection or treatment of skin or hair damages caused by chemotherapeutic treatment. The invention also concerns a method for the protection or treatment of skin and hair damages of a mammal caused by chemotherapy. The invention further relates to a kit for the protection or treatment of hair damages caused by chemotherapeutic treatment consisting of a topical composition comprising microparticles together with free radical scavengers and a shampoo for an effective hair cleaning and supporting the hair treatment. A kit for the protection or treatment of skin damages caused by chemotherapy consisting of a topical composition comprising microparticles together with free radical scavengers and a cleansing milk for an effective skin cleaning and supporting the skin treatment is a further object of the present invention.

Priority: DE200510021804 Applic. Date: 2005-05-04; DE200510023497 Applic. Date: 2005-05-18; WO2006EP62076 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Application No.: US20090069279A1  Published: 12/Mar/2009

Title: INVERT EMULSIONS CONTAINING DHEA

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 12/168356   Filing Date: 07/Jul/2008

Abstract:Stable, recrystallization-resistant invert emulsions, suited, e.g., for preventing/treating the signs of chronological or actinic skin aging and for preventing/treating atrophy of the skin or mucous membranes, comprise a cosmetically/therapeutically effective amount of DHEA and/or chemical and/or biological precursor or derivative thereof, such invert emulsions also comprising a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7.

Priority: FR20010010398 Applic. Date: 2001-08-02; US2004-767814 Applic. Date: 2004-01-30; WO2002FR02569 Applic. Date: 2002-07-18

Inventor: ASTRUC FANNY [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]; SIMONNET JEAN-THIERRY [FR]; RICHART PASCAL [FR]


Application No.: US20090069288A1  Published: 12/Mar/2009

Title: Novel therapeutic compounds

Applicant/Assignee:

Application No.: 12/218364   Filing Date: 15/Jul/2008

Abstract:Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

Priority: US20070959631P Applic. Date: 2007-07-16

Inventor: BREINLINGER ERIC C [US]; CUSACK KEVIN P [US]; HOBSON ADRIAN D [US]; LI BIN [US]; GORDON THOMAS D [US]; STOFFEL ROBERT H [US]; WALLACE GRIER A [US]; GRONGSAARD PINTIPA [US]; WANG LU [US]; WANG LU [US]


Application No.: US20090069305A1  Published: 12/Mar/2009

Title: Substituted nitrogen-containing heteroaryl derivatives useful as modulators of the histamine H4 receptor

Applicant/Assignee:

Application No.: 12/283488   Filing Date: 11/Sep/2008

Abstract:The present invention relates to substituted nitrogen-containing heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using any of these derivatives and compositions for H4 receptor activity modulation and the treatment of states mediated by histamine H4 receptor activity.

Priority: US20070971676P Applic. Date: 2007-09-12

Inventor: GAUL MICHAEL D [US]; ZHAO BAO-PING [US]; ZHU XIZHEN [US]


Application No.: US20090069439A1  Published: 12/Mar/2009

Title: Use of pargyline for the treatment of hair folliclies

Applicant/Assignee: CUTECH S.R.I

Application No.: 12/231385   Filing Date: 02/Sep/2008

Abstract:Use of Pargyline for the production of a medicament for influencing the metabolism of hair follicles and the modulation of their vital cycle.

Priority: EP20070017594 Applic. Date: 2007-09-07

Inventor: PERTILE PAOLO [IT]


Application No.: US20090069522A1  Published: 12/Mar/2009

Title: HYDROPHOBICALLY MODIFIED POLYMERS

Applicant/Assignee:

Application No.: 11/853084   Filing Date: 11/Sep/2007

Abstract:This invention pertains to composition comprising one or more hydrophobically modified polyacrylamides, wherein the polyacrylamides contain acrylamide, one or more anionic monomers, and excludes a cationic monomer, and a method of using the composition for consumer and/or industrial applications.

Priority:

Inventor: HESSEFORT YIN Z [US]; MAREK PATRICK J [US]; CRAMM JEFFREY R [US]; PATEL DAMYANTI J [US]; CARLSON WAYNE M [US]


Application No.: US20090069658A1  Published: 12/Mar/2009

Title: Analyte Monitoring Device and Methods of Use

Applicant/Assignee: ABBOTT DIABETES CARE, INC

Application No.: 12/210122   Filing Date: 12/Sep/2008

Abstract:An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Priority: US2003-420057 Applic. Date: 2003-04-18; US2000-667199 Applic. Date: 2000-09-21; US1998-070677 Applic. Date: 1998-04-30

Inventor: SAY JAMES [US]; TOMASCO MICHAEL F [US]; HELLER ADAM [US]; GAL YORAM [IL]; ARIA BEHRAD [US]; HELLER EPHRAIM [US]; PLANTE PHILLIP JOHN [US]; VREEKE MARK S [US]; FRIEDMAN KEITH A [US]; COLMAN FREDRIC C [US]


Application No.: US20090074675A1  Published: 19/Mar/2009

Title: INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS

Applicant/Assignee: GLAXO GROUP LIMITED

Application No.: 11/910935   Filing Date: 12/Apr/2006

Abstract:A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl

X represents -C(R3)- or nitrogen

when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen

and Y represents H or methyl

or a physiologically functional derivative thereof.

Priority: GB20050007597 Applic. Date: 2005-04-14; GB20050016375 Applic. Date: 2005-08-09; GB20050022882 Applic. Date: 2005-11-09; WO2006EP03551 Applic. Date: 2006-04-12

Inventor: ELDRED COLIN DAVID [GB]; HOUSE DAVID [GB]; INGLIS GRAHAM GEORGE ADAM [GB]; MACDONALD SIMON JOHN FAWCETT [GB]; SKONE PHILIP ALAN [GB]


Application No.: US20090074677A1  Published: 19/Mar/2009

Title: Neuroactive steroid compositions and methods of use therefor

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 12/008259   Filing Date: 08/Jan/2008

Abstract:Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

Priority: US20070879165P Applic. Date: 2007-01-08

Inventor: MARX CHRISTINE E [US]; ROSE JED E [US]


Application No.: US20090074681A1  Published: 19/Mar/2009

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORP

Application No.: 12/291742   Filing Date: 13/Nov/2008

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain dialkylhydroxyamine stabilizers, dialkylhydroxylamine stabilizer salts, nitrone stabilizers or amine oxide stabilizers. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US2007-901423 Applic. Date: 2007-09-17; US2004-970112 Applic. Date: 2004-10-21; US20030515889P Applic. Date: 2003-10-30

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MARVIN G [US]


Application No.: US20090074682A1  Published: 19/Mar/2009

Title: SILANE ESTERS AND AMIDES OF 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID, AND COSMETIC USES THEREOF

Applicant/Assignee: L'OREAL

Application No.: 11/577600   Filing Date: 27/Sep/2005

Abstract:The present invention relates to novel compounds of formula (1) and also to cosmetic compositions containing them and to the cosmetic uses thereof, in particular for protecting the skin against UV-induced oxidative stress.

Priority: FR20040052399 Applic. Date: 2004-10-21; US20040632541P Applic. Date: 2004-12-03; WO2005EP12032 Applic. Date: 2005-09-27

Inventor: LUCET-LEVANNIER KARINE [FR]


Application No.: US20090074753A1  Published: 19/Mar/2009

Title: PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 12/323183   Filing Date: 25/Nov/2008

Abstract:A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

Priority: US2005-159533 Applic. Date: 2005-06-23; US2004-965319 Applic. Date: 2004-10-14

Inventor: LYNCH SAMUEL E [US]


Application No.: US20090074820A1  Published: 19/Mar/2009

Title: AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF

Applicant/Assignee: L'OREAL

Application No.: 12/277784   Filing Date: 25/Nov/2008

Abstract:The invention relates to the use of at least one agent for screening out light radiation with a wavelength ranging from 370 to 500 nm as an agent for inhibiting the degradation of endogenous carotenoids present in the skin. The invention is useful for treating skin disorders caused by sunlight (e.g., solar urticaria, actinic dermatitis and pigmentation marks). The invention also relates to novel aminoaryl-vinyl-s-triazine compounds and to the use thereof as agents for screening out light radiation ranging from 370 to 500 nm.

Priority: FR20030006800 Applic. Date: 2003-06-05; US2004-859404 Applic. Date: 2004-06-03; US20030508312P Applic. Date: 2003-10-06

Inventor: CANDAU DIDIER [FR]; DURANTON ALBERT [FR]; PRUCHE FRANCIS [FR]; RICHARD HERVE [FR]


Application No.: US20090074845A1  Published: 19/Mar/2009

Title: TRANSDERMAL ACTIVE PRINCIPLE DELIVERY MEANS

Applicant/Assignee: HENDERSON MORLEY PLC

Application No.: 12/065591   Filing Date: 22/Aug/2006

Abstract:A transdermal active principle delivery means comprises a skin adherent or otherwise skin-tolerant substrate applicable to a skin area affected by DNA virus, which substrate includes a composition for treating DNA comprising a transdermally effective carrier medium including at least one active principle selected from the group consisting of diuretic agents and/or cardiac glycoside agents.

Priority: GB20050017838 Applic. Date: 2005-09-02; WO2006GB03143 Applic. Date: 2006-08-22

Inventor: PARDOE IAN STUART [GB]; HARTLEY CHRISTOPHER [GB]


Application No.: US20090074875A1  Published: 19/Mar/2009

Title: Nanoparticulate compositions having lysozyme as a surface stabilizer

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LTD

Application No.: 12/292091   Filing Date: 12/Nov/2008

Abstract:The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.

Priority: US2003-357514 Applic. Date: 2003-02-04; US20020353230P Applic. Date: 2002-02-04

Inventor: WERTZ CHRISTIAN F [US]; RYDE NIELS P [US]


Application No.: US20090075856A1  Published: 19/Mar/2009

Title: Encapsulated Bleaching Agent Particles

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 12/273722   Filing Date: 19/Nov/2008

Abstract:A shelf-stable liquid agent or detergent containing a bleaching agent in the form of a finely particulate bleaching agent encapsulated in a crosslinkable polymer matrix.

Priority: DE200610023937 Applic. Date: 2006-05-19; WO2007EP54528 Applic. Date: 2007-05-10

Inventor: SCHMIEDEL PETER [DE]; VOELKEL HEINZ-JUERGEN [DE]; KAISER HERIBERT [DE]; VON RYBINSKI WOLFGANG [DE]; HOELSKEN SOEREN [DE]; BLANK VOLKER [DE]; GUCKENBIEHL BERNHARD [DE]


Application No.: US20090075935A1  Published: 19/Mar/2009

Title: COMPOSITION COMPRISING AT LEAST ONE C-GLYCOSIDE DERIVATIVE AND AT LEAST ONE HYALURONIC ACID AND ITS COSMETIC USE

Applicant/Assignee: L'OREAL

Application No.: 12/192698   Filing Date: 15/Aug/2008

Abstract:The present invention relates to a topical cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium, at least one hyaluronic acid or a derivative thereof and at least one C-glycoside derivative.

Priority: WO2007FR51579 Applic. Date: 2007-07-02; US20070968892P Applic. Date: 2007-08-30; US20060817683P Applic. Date: 2006-07-03; US20070894254P Applic. Date: 2007-03-12

Inventor: BISSEY LAURE [FR]; LABOUREAU JULIEN [FR]; SENEE JEROME [FR]; SAUSSAY SOPHIE [FR]


Application No.: US20090075970A1  Published: 19/Mar/2009

Title: Thieno-and furo-pyrimidine modulators of the histamine H4 receptor

Applicant/Assignee:

Application No.: 12/283700   Filing Date: 12/Sep/2008

Abstract:Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.

Priority: US20070972589P Applic. Date: 2007-09-14

Inventor: EDWARDS JAMES P [US]; NEFF DANIELLE K [US]; SMITH DEBORAH M [US]; VENABLE JENNIFER D [US]


Application No.: US20090076174A1  Published: 19/Mar/2009

Title: CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS

Applicant/Assignee: BEZWADA BIOMEDICAL, LLC

Application No.: 12/203761   Filing Date: 03/Sep/2008

Abstract:The present invention relates to the discovery of biodegradable multi-armed oligomers wherein the end groups of these oligomers have been functionalized with biologically active molecules. The resultant multi-armed oligomers end-functionalized with biologically active molecules have a controllable degradation profile. The hydrolytic degradation of oligomers of the present invention releases the biologically active compound as such with no change in native chemical structure.

Priority: US20070969787P Applic. Date: 2007-09-04

Inventor: BEZWADA RAO S [US]


Application No.: US20090076479A1  Published: 19/Mar/2009

Title: DEVICE FOR TREATMENT OF BARRIER MEMBRANES

Applicant/Assignee:

Application No.: 12/272198   Filing Date: 17/Nov/2008

Abstract:The present invention features a device having a barrier membrane contacting surface, the device containing: a power source

a first conductive electrode

a second conductive electrode

and a carrier

wherein the power source is in electric communication with the first conductive electrode and the second conductive electrode, wherein the first conductive electrode and the second conductive electrode are in ionic communication with the carrier, and wherein the carrier is in communication with the barrier membrane contacting surface.

Priority: US2003-609727 Applic. Date: 2003-06-30

Inventor: SUN YING [US]; LIU JUE-CHEN [US]; WU JEFFREY M [US]; HAUSCHILD JAMES E [US]


Application No.: US20090081137A1  Published: 26/Mar/2009

Title: Crosslinked Polytetrahydrofuran-Containing Polyurethanes

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/658268   Filing Date: 22/Jul/2005

Abstract:The invention relates to a cross-linked polyurethane, which contains, in an integrated manner, at least one polytetrahydrofuran and one polyisocyanate mixture, to cosmetic or pharmaceutical agents containing a polyurethane of the aforementioned type, and to the use of these polyurethanes.

Priority: DE200410036146 Applic. Date: 2004-07-26; WO2005EP08040 Applic. Date: 2005-07-22

Inventor: NGUYEN KIM SON [DE]; KAISER THOMAS [DE]; HAUCK RALF [DE]


Application No.: US20090081139A1  Published: 26/Mar/2009

Title: Water-based delivery systems

Applicant/Assignee:

Application No.: 12/082406   Filing Date: 09/Apr/2008

Abstract:The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

Priority: US2003-388371 Applic. Date: 2003-03-13; US20020365059P Applic. Date: 2002-03-13

Inventor: SKOLD THOMAS [SE]


Application No.: US20090081141A1  Published: 26/Mar/2009

Title: TOPICAL USE OF THIAZOLIDINE DERIVATIVES AGAINST CONSEQUENCES OF OXIDATIVE STRESS OF SKIN

Applicant/Assignee: EXSYMOL S.A.M

Application No.: 12/233661   Filing Date: 19/Sep/2008

Abstract:A cosmetic composition intended for protecting skin against stress generating free radicals or reactive oxygen species is disclosed. The cosmetic composition comprises a physiologically compatible excipient and a thiazolidine compound. Methods of protecting skin generally and against cutaneous consequences of oxidative stress are also disclosed.

Priority: FR20070006641 Applic. Date: 2007-09-21

Inventor: SEGUIN MARIE CHRISTINE [MC]


Application No.: US20090081143A1  Published: 26/Mar/2009

Title: Extracts From Black Yeast For Whitening Skin

Applicant/Assignee:

Application No.: 11/860909   Filing Date: 25/Sep/2007

Abstract:The present invention relates to topical skin whitening compositions comprising a whitening effective amount of a black yeast-derived melanin-degrading enzyme extract and a method of preparing the compositions. The compositions provide a whitening effect by degrading melanin on the surface of the skin, the hair and the nails. The enzyme extract can be derived from Exophiala mansonii. The compositions containing the enzyme extract are more effective than are similar compositions containing kojic acid in producing a whitening effect on the skin.

Priority:

Inventor: MAMMONE THOMAS [US]; MUIZZUDDIN NEELAM [US]; SCHNITTGER STEVEN F [US]


Application No.: US20090081151A1  Published: 26/Mar/2009

Title: Olefin wax, silicone-modified olefin wax, silicone-modified room temperature-solidifying composition using the wax, and cosmetics using them

Applicant/Assignee: MITSUI CHEMICALS, INC SHIN-ETSU CHEMICAL CO., LTD

Application No.: 12/292724   Filing Date: 25/Nov/2008

Abstract:An olefin wax (A) is (i) a copolymer (A1) obtained by copolymerizing ethylene and at least one diene or a copolymer (A2) obtained by copolymerizing ethylene, at least one olefin selected from alpha-olefins of 3 to 12 carbon atoms and at least one diene

wherein (ii) the content of unsaturated groups per one molecule is in the range of 0.5 to 3.0 groups

(iii) the density is in the range of 870 to 980 kg/m3

(iv) the melting point is in the range of 70 to 130 DEG C.

(v) the number-average molecular weight is in the range of 400 to 5,000

and (vi) the ratio (Mw/Mn) of the weight-average molecular weight to the number-average molecular weight is not more than 4.0. A silicone-modified olefin wax can be obtained by reacting hydrogen silicone with the olefin wax (A). Cosmetics contain the silicone-modified olefin wax.

Priority: JP20020302202 Applic. Date: 2002-10-16; US2005-531377 Applic. Date: 2005-09-26; WO2003JP13265 Applic. Date: 2003-10-16

Inventor: TOYODA HIDEO [JP]; UOSAKI HIROTAKA [JP]; KAN KOUJIRO [JP]; ICHINOHE SHOJI [JP]; SHIMIZU TORU [JP]


Application No.: US20090081155A1  Published: 26/Mar/2009

Title: Use of Inhibitors of Indoleamine-2,3-Dioxygenase in Combination with Other Therapeutic Modalities

Applicant/Assignee: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC

Application No.: 12/175538   Filing Date: 18/Jul/2008

Abstract:The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.

Priority: US2004-780797 Applic. Date: 2004-02-17; US20030459489P Applic. Date: 2003-04-01; US20040538647P Applic. Date: 2004-01-22

Inventor: MUNN DAVID [US]; MELLOR ANDREW [US]


Application No.: US20090081262A1  Published: 26/Mar/2009

Title: METAL OXIDE COATING OF WATER INSOLUBLE INGREDIENTS

Applicant/Assignee: SOL-GEL TECHNOLOGIES LTD

Application No.: 11/997823   Filing Date: 02/Aug/2006

Abstract:The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential

(b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon

and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

Priority: US20050704455P Applic. Date: 2005-08-02; WO2006IL00892 Applic. Date: 2006-08-02

Inventor: TOLEDANO OFER [IL]; SERTCHOOK HANAN [IL]; LOBODA NATALIA [IL]; BAR-SIMANTOV HIAM [IL]


Application No.: US20090081274A1  Published: 26/Mar/2009

Title: MAST CELL-DERIVED RENIN

Applicant/Assignee: CORNELL RESEARCH FOUNDATION, INC

Application No.: 12/237176   Filing Date: 24/Sep/2008

Abstract:The invention relates to the discovery that renin is present in mast cells and can act in a localized manner to initiate and/or exacerbate a number of conditions. Thus, the invention provides methods for treating cardiac, vascular, lung, liver, cervical, intestinal, muscle, pancreatic, brain, kidney, skin and other conditions that involve inhibiting the synthesis and/or release of renin from mast cells and/or inhibiting the activity of renin after release from mast cells. The methods of the invention can also involve inhibiting elements of the local renin-angiotensin system (e.g. inhibiting ACE and angiotensin II receptors), thereby inhibiting angiotensin II produced locally from mast-cell-derived renin

Priority: US2007-657343 Applic. Date: 2007-01-24; US2004-964567 Applic. Date: 2004-10-13; US20030512142P Applic. Date: 2003-10-17

Inventor: SILVER RANDI B [US]; LEVI ROBERTO [US]


Application No.: US20090081285A1  Published: 26/Mar/2009

Title: USE OF RADICAL-CAPTURING SUBSTANCES IN A TOPICAL PREPARATION FOR ANTIPYRETIC TREATMENT

Applicant/Assignee:

Application No.: 11/913488   Filing Date: 04/May/2006

Abstract:The present invention relates to the use of one or more radical-capturing substances as therapeutically active substances in a topical preparation for antipyretic treatment. The invention is also directed to the use of radical-capturing substances as active agents in a combined preparation for the treatment of fever, said combined preparation comprising a topical preparation and an oral preparation in free combination, and the two preparations independently including one or more free-radical-capturing substances. According to the invention, the two preparations of the combined preparation are intended for simultaneous, separate or time-differentiated administration.

Priority: DE200510021806 Applic. Date: 2005-05-04; WO2006EP62075 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Application No.: US20090081305A1  Published: 26/Mar/2009

Title: Compositions and Methods for Enhancing In-Vivo Uptake of Pharmaceutical Agents

Applicant/Assignee: DO-COOP TECHNOLOGIES LTD

Application No.: 12/087428   Filing Date: 04/Jan/2007

Abstract:Pharmaceutical compositions comprising liquid, nanostructures and pharmaceutical agents are provided. Methods of use such compositions are also provided.

Priority: IL20010147049 Applic. Date: 2001-12-12; US2006-324586 Applic. Date: 2006-01-04; WO2005IL00198 Applic. Date: 2005-02-17; US2004-865955 Applic. Date: 2004-06-14; WO2002IL01004 Applic. Date: 2002-12-12; US20060755852P Applic. Date: 2006-01-04; US20060755850P Applic. Date: 2006-01-04; US20060755851P Applic. Date: 2006-01-04; US20040545955P Applic. Date: 2004-02-20; WO2007IL00014 Applic. Date: 2007-01-04

Inventor: GABBAI ERAN [IL]


Application No.: US20090081316A1  Published: 26/Mar/2009

Title: Boron nitride-containing silicone gel composition

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS INC

Application No.: 11/903109   Filing Date: 20/Sep/2007

Abstract:A stable silicone oil composition is provided which comprises: a) at least one silicone gel

b) at least one boron nitride powder (a)

c) a static charge-dissipating amount of at least one silicone oil

and, d) optionally, at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and/or absorbing agent, botanical extract, peptide, protein, organic oil, gum, saccharide, oligosaccharide, polysaccharide, derivative, wax, film former, thickening agent, particulate filler, plasticizer, humectant, occlusive, sensory enhancer, resin and optically active particle.

Priority:

Inventor: WAHL ROY UWE ROJAS [US]; DUFFY JANET LYNN [US]


Application No.: US20090081783A1  Published: 26/Mar/2009

Title: Method for producing langerhans cells or interstitial dendritic cells or both from CD14+ monocytes

Applicant/Assignee:

Application No.: 11/897617   Filing Date: 01/Sep/2007

Abstract:The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells, or both, from CD14+ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD14+ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14+ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells. The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.

Priority:

Inventor: BECHETOILLE NICOLAS [FR]; ANDRE VALERIE [FR]; ORLY ISABELLE [FR]; PERRIER ERIC [FR]


Application No.: US20090082268A1  Published: 26/Mar/2009

Title: Muteins of Placental Growth Factor Type I, Preparation Method And Application Thereof

Applicant/Assignee: GEYMONAT S.P.A

Application No.: 11/967469   Filing Date: 31/Dec/2007

Abstract:The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.

Priority: IT2002RM00277 Applic. Date: 2002-05-17; US2005-514707 Applic. Date: 2005-01-07; WO2003IT00296 Applic. Date: 2003-05-19

Inventor: SALVIA GIUSEPPE [IT]


Application No.: US20090082287A1  Published: 26/Mar/2009

Title: METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES

Applicant/Assignee: PARION SCIENCES, INC

Application No.: 11/852003   Filing Date: 07/Sep/2007

Abstract:The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.

Priority: US20060842963P Applic. Date: 2006-09-08; US20060842669P Applic. Date: 2006-09-07

Inventor: JOHNSON MICHAEL ROSS [US]; BOUCHER RICHARD C [US]; HIRSH ANDREW J [US]


Application No.: US20090082328A1  Published: 26/Mar/2009

Title: Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity

Applicant/Assignee: BAYER HEALTHCARE AG

Application No.: 12/151855   Filing Date: 09/May/2008

Abstract:This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

Priority: EP20080075314 Applic. Date: 2008-04-22; US20070928789P Applic. Date: 2007-05-11

Inventor: LI YINGFU [US]; RUDOLPH JOACHIM [US]; DUMAS JACQUES P [US]; AUCLAIR DANIEL [US]; LOBELL MARIO [DE]; HITCHCOCK MARION [DE]; HARTUNG INGO [DE]; KOPPITZ MARCUS [DE]; BRITTAIN DOMINIC [DE]; PUEHLER FLORIAN [DE]; PETERSEN KIRSTIN [DE]; GUENTHER JUDITH [DE]


Application No.: US20090082342A1  Published: 26/Mar/2009

Title: N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS

Applicant/Assignee: ACADIA PHARMACEUTICALS, INC

Application No.: 12/234582   Filing Date: 19/Sep/2008

Abstract:Disclosed herein are isolated forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, methods inhibiting an activation of a serotonin receptor, and methods of alleviating or treating various disease conditions and side effects.

Priority: US20070974426P Applic. Date: 2007-09-21; US20080050976P Applic. Date: 2008-05-06

Inventor: ULDAM HENRIETTE KOLD [DK]; THYGESEN MIKKEL BOAS [DK]


Application No.: US20090087462A1  Published: 02/Apr/2009

Title: Use of pyrimidine derivatives for cosmetic purposes

Applicant/Assignee:

Application No.: 11/921656   Filing Date: 12/Jun/2006

Abstract:The present invention is directed to the use of certain pyrimidine derivatives for cosmetic purposes, i.e. for the preparation of a composition for providing a cosmetic effect. It was found that said pyrimidine derivatives are particularly useful for treating wrinkles but also for thickening the epidermis, for improving hair growth and for treating grey hair. The present invention is also directed to a composition containing said pyrimidine derivatives. In particular, said composition is a cosmetic preparation.

Priority: WO2006EP05609 Applic. Date: 2006-06-12; EP20050013111 Applic. Date: 2005-06-17; EP20060754298 Applic. Date: 2006-06-12

Inventor: TREMBLEY MARCELLA [DE]; VOLLHARDT JUERGEN H [CH]


Application No.: US20090087469A1  Published: 02/Apr/2009

Title: ALGINATE-BASED NANOFIBERS AND RELATED SCAFFOLDS

Applicant/Assignee: WASHINGTON, UNIVERSITY OF

Application No.: 12/239478   Filing Date: 26/Sep/2008

Abstract:Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning.

Priority: WO2007US65388 Applic. Date: 2007-03-28; US20060787099P Applic. Date: 2006-03-28

Inventor: ZHANG MIQIN [US]; BHATTARAI NARAYAN [US]


Application No.: US20090087499A1  Published: 02/Apr/2009

Title: DEPILATORY PRODUCT

Applicant/Assignee:

Application No.: 12/111314   Filing Date: 29/Apr/2008

Abstract:The invention comprises a depilatory product based on a complexing gel. The product will remove the hair via reduction and hydrolysis as do chemical depilatories. Despite the peeling nature of the product, the hair is not removed by pulling it out like a wax depilatory. The product is to be applied as a single step from a component that allows the mixing of two separate parts during application to the skin. The final gel is plastic and pliable but non-mobile similar to silicone rubber. The gel should possess strength so that it can be removed from the skin as a single piece without breaking or ripping.

Priority: US20070997005P Applic. Date: 2007-09-28

Inventor: OTT JR DAVID S [US]


Application No.: US20090088341A1  Published: 02/Apr/2009

Title: MULTIPLEX ASSAY METHOD FOR MIXED CELL POPULATIONS

Applicant/Assignee: THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES

Application No.: 12/060752   Filing Date: 01/Apr/2008

Abstract:Disclosed is an in vitro assay for evaluating cellular activity, in which a culture is provided that contains one or more histologically different isolated mammalian cell-line that stably and constitutively express fluorescent proteins having a different emission spectra. The culture is assessed for cellular activity by quantifying fluorescence or detecting a pattern of fluorescence from fluorescent proteins present in the culture. In some embodiments, the cellular activity of the cell-lines is assessed by determining one or more of the growth rate, migration potential, or tubule formation potential of the cell-lines using the quantified fluorescence or pattern of fluorescence. Also disclosed are cell-lines have been stably transfected with mammalian expression plasmids that constitutively express different fluorescent proteins. Kits for performing the disclosed assays, which include the disclosed fluorescent cell-lines, are also disclosed.

Priority: US20070976732P Applic. Date: 2007-10-01

Inventor: ZUDAIRE ENRIQUE [US]; CUTTITTA FRANK [US]


Application No.: US20090088368A1  Published: 02/Apr/2009

Title: COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS

Applicant/Assignee: IRM LLC

Application No.: 12/160307   Filing Date: 25/Jan/2007

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US20060763539P Applic. Date: 2006-01-30; WO2007US02316 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT [US]; RUSSO ROSS [US]; AZIMIOARA MIHAI [US]


Application No.: US20090088458A1  Published: 02/Apr/2009

Title: N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators

Applicant/Assignee:

Application No.: 11/989412   Filing Date: 28/Jul/2006

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20050704702P Applic. Date: 2005-08-02; WO2006US29457 Applic. Date: 2006-07-28

Inventor: MEISSNER ROBERT S [US]; PERKINS JAMES J [US]; KIM YUNTAE [US]; HANNEY BARBARA [US]; MCVEAN CAROL A [US]


Application No.: US20090092561A1  Published: 09/Apr/2009

Title: Body-care and household products and compositions comprising specific sulfur-containing compounds

Applicant/Assignee:

Application No.: 12/229815   Filing Date: 27/Aug/2008

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise specific sulfur containing compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US20070998162P Applic. Date: 2007-10-09

Inventor: LUPIA JOSEPH A [US]; REICH OLIVER [DE]


Application No.: US20090092642A1  Published: 09/Apr/2009

Title: Skin and/or Hair Products, Containing Compounds With an Isoprenoid Structure

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/587577   Filing Date: 08/Dec/2006

Abstract:A composition of matter that is suitable for use on skin or hair. The composition comprises one or more compounds of formula wherein Rx, Ry, R3 and R5 are as defined in the specification, and at least one other component or element.

Priority: DE200410020714 Applic. Date: 2004-04-26; WO2005EP51528 Applic. Date: 2005-04-06

Inventor: WOLBER RAINER [DE]; KRUSE INGE [DE]; SCHLENZ KATHRIN [DE]; SCHERNER CATHRIN [DE]; TOM DIECK KAREN [DE]


Application No.: US20090093341A1  Published: 09/Apr/2009

Title: Music and Accelerometer Combination Device for Collecting, Converting, Displaying and Communicating Data

Applicant/Assignee:

Application No.: 11/866520   Filing Date: 03/Oct/2007

Abstract:A method for integrating and managing data is provided that includes interacting with an end user via a music and health component combination device, the device including: a health component that is operable to track data by the user and a music module operable to play music for the user. The device further includes a memory and a processor operable to convert data from the health component into one or more metrics based on data received from the memory. In other embodiments, the device can display a category of music, such as an album or a play list. The device also includes a dimming function that allows certain parameters being displayed by the device to be highlighted, emphasized, or deemphasized.

Priority:

Inventor: JAMES TERRY L [US]; JAMES GRANT K [US]


Application No.: US20090093440A1  Published: 09/Apr/2009

Title: Fragranced Therapeutic Delivery System

Applicant/Assignee:

Application No.: 12/086911   Filing Date: 20/Dec/2006

Abstract:The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase

(ii) an aqueous phase

(iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition

(iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group

(v) a non-ionic emulsifier having an HLB of from about 7 to about 10

(vi) a fragrance composition

and (vii) at least one skin-supporting or dermatopharmaceutically active agent.

Priority: US20050751635P Applic. Date: 2005-12-20; WO2006US48383 Applic. Date: 2006-12-20

Inventor: MURAD HOWARD [US]


Application No.: US20090093474A1  Published: 09/Apr/2009

Title: THIAZOLYL-DIHYDRO-INDAZOLE

Applicant/Assignee:

Application No.: 12/277543   Filing Date: 25/Nov/2008

Abstract:The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I) wherein the groups R1, R2 and R3 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.

Priority: EP20060112297 Applic. Date: 2006-04-06; US2007-690351 Applic. Date: 2007-03-23

Inventor: GRAUERT MATTHIAS [DE]; MAIER UDO [DE]; HOFFMANN MATTHIAS [DE]; SCHEUERER STEFAN [DE]; JOERGENSEN ANNE T [DE]; PAUTSCH ALEXANDER [DE]; BRANDL TRIXI [CH]; HOENKE CHRISTOPH [DE]; BREITFELDER STEFFEN [DE]; ERB KLAUS [DE]; PIEPER MICHAEL [DE]; PRAGST INGO [DE]


Application No.: US20090093509A1  Published: 09/Apr/2009

Title: Methods and Compositions for the Treatment of Pruritus

Applicant/Assignee:

Application No.: 12/247618   Filing Date: 08/Oct/2008

Abstract:The present invention is based on the discovery that a nalmefene salt or a peripherally acting analogue of nalmefene is capable of providing long-acting activity against pruritus, when applied topically. In addition, treatment with a nalmefene salt or peripherally acting analogue of nalmefene, can provide disease-modifying effects against the chronic symptoms of atopic dermatitis, including reductions of inflammatory cell infiltrate into the skin, epidermal hyperplasia and trans-epidermal water loss. Compositions of the invention have an inhibitory effect on the itch-scratch-cycle, leading to both relief of pruritus and disease-modifying activity.

Priority: GB20070019613 Applic. Date: 2007-10-08; GB20080009319 Applic. Date: 2008-05-22

Inventor: NAZIR TAHIR [GB]; BAXTER ANDREW DOUGLAS [GB]; ROTHAUL ALAN [GB]


Application No.: US20090093536A1  Published: 09/Apr/2009

Title: PHARMACEUTICAL COMPOSITION COMPRISING THIACREMONONE FOR PREVENTING OR TREATING CANCER

Applicant/Assignee: CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Application No.: 12/186534   Filing Date: 06/Aug/2008

Abstract:The present invention relates to an anti-cancer composition, which comprises a sulfur-containing compound thiacremonone as an active ingredient. The active ingredient induces the death of cancer cells by apoptosis through the action of specific inhibition of the activity of NF-kappaB. The composition can be effectively used in the treatment or prevention of cancer.

Priority: KR20070100998 Applic. Date: 2007-10-08

Inventor: HONG JIN TAE [KR]; BAN JUNG OK [KR]; JEONG HEON-SANG [KR]; KIM DAE JOONG [KR]


Application No.: US20090098065A1  Published: 16/Apr/2009

Title: COMPOSITION AND METHODS FOR THE TREATMENT OF SKIN DISORDERS

Applicant/Assignee:

Application No.: 12/242243   Filing Date: 30/Sep/2008

Abstract:Methods and pharmaceutical compositions for use in the treatment of benign or malignant proliferative pathologies are disclosed. The methods involve the topical administration of nicotinamide or a nicotinamide derivative in combination with a vitamin D compound. The combination is shown to act in synergy and is especially useful for treatment of psoriasis and other skin disorders.

Priority: IL20000133976 Applic. Date: 2000-01-11; US2002-192842 Applic. Date: 2002-07-11; WO2001IL00017 Applic. Date: 2001-01-09; US2008-914093 Applic. Date: 2008-06-10; WO2006IL00552 Applic. Date: 2006-05-10; US2008-914102 Applic. Date: 2008-06-10; WO2006IL00553 Applic. Date: 2006-05-10; US20050679329P Applic. Date: 2005-05-10; US20050679556P Applic. Date: 2005-05-10

Inventor: HAREL AVIKAM [IL]; BLOCH OLGA [IL]


Application No.: US20090098076A1  Published: 16/Apr/2009

Title: Method For the Production of a Keratin-Binding Effector Molecule

Applicant/Assignee: BASF SE

Application No.: 12/094833   Filing Date: 15/Nov/2006

Abstract:The invention relates to a method of producing keratin-binding effector molecules, and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. In addition, the invention relates to a method of applying dermocosmetically active ingredients to skin and/or hair and to a method of increasing the residence time of an active ingredient on skin and hair.

Priority: EP20050111218 Applic. Date: 2005-11-24; EP20060116386 Applic. Date: 2006-06-30; WO2006EP68470 Applic. Date: 2006-11-15

Inventor: BARG HEIKO [DE]; LIEBMANN BURGHARD [DE]; VOLKERT MARTIN [DE]; PTOCK ARNE [DE]; REENTS HEIKE [DE]


Application No.: US20090098096A1  Published: 16/Apr/2009

Title: AGENT FOR CORRECTING STRESS-INDUCING NEURO-MEDIATOR, NEURO-ENDOCRINE AND METABOLIC DISTURBANCES AND METHOD FOR PREVENTING AND TREATING CONCOMITANT PATHOLOGICAL CONDITIONS

Applicant/Assignee:

Application No.: 12/066153   Filing Date: 23/Aug/2006

Abstract:The invention relates to medicine, in particular to pharmacology, and is embodied in the form of an agent for limiting neuro-mediator, neuro-endocrine and metabolic disturbances generating the disorders of a central nervous system and functional somatic disorders. The inventive agent is based on a DSIP (delta sleep inducing peptide) or a derivative chemically related thereto and can be used for correcting and preventing functional shifts in a central nervous system and concomitant somatic disorders caused by unfavourable and extreme environmental factors and different pathological conditions of an organism or during the ageing thereof. The inventive method for preventing and treating stress states with the aid of the inventive agent is characterised in that the inventive compositions can be administrated: intranasally in the form of intranasal drops or spray

sublingually in the form of resorbable tablets and capsules

in the form of powders, suppositories, ointments and creams

in the form of different injections (intracutaneous, hypodermic, intramuscular, and intravenous)

in the form of different cosmetic agents (creams, lotions, tonics, cosmetic milk, foam, soap, etc.) and in the form of infant food components.

Priority: RU20050128993 Applic. Date: 2005-09-08; WO2006RU00468 Applic. Date: 2006-08-23

Inventor: MIKHALEVA INESA IVANOVNA [RU]; IVANOV VADIM TIKHONOVICH [RU]; PRUDCHENKO IGOR ARKADJEVICH [RU]; VOITENKOV BORIS OLEGOVICH [RU]


Application No.: US20090098131A1  Published: 16/Apr/2009

Title: Compositions and methods for the treatment of immune related diseases

Applicant/Assignee:

Application No.: 12/153928   Filing Date: 28/May/2008

Abstract:The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US2003-533519 Applic. Date: 2003-10-30; WO2003US34312 Applic. Date: 2003-10-30; US20020423394P Applic. Date: 2002-11-01

Inventor: CLARK HILARY [US]; SCHOENFELD JILL R [US]; VANLOOKEREN MENNO [US]; WILLIAMS P MICKEY [US]; WOOD WILLIAM I [US]; WU THOMAS D [US]


Application No.: US20090098133A1  Published: 16/Apr/2009

Title: Tetrahydropyridothiophenes as Antiproliferative Agents for the Treatment of Cancer

Applicant/Assignee: ALTANA PHARMA AG 4SC AG

Application No.: 11/883624   Filing Date: 10/Feb/2006

Abstract:Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Priority: EP20050101007 Applic. Date: 2005-02-11; EP20050104493 Applic. Date: 2005-05-25; EP20050112159 Applic. Date: 2005-12-14; WO2006EP50859 Applic. Date: 2006-02-10

Inventor: PEKARI KLAUS [DE]; SCHMIDT MATHIAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [NL]; BARTELS BJORN [DE]


Application No.: US20090098171A1  Published: 16/Apr/2009

Title: Cosmetic composition in the form of an emulsion comprising a continuous aqueous phase and a dispersed fatty phase, and method for its preparation

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/284861   Filing Date: 25/Sep/2008

Abstract:The invention relates to a composition in the form of an emulsion comprising a continuous aqueous phase and a dispersed fatty phase, characterized in that said aqueous phase contains liposomes in the presence of a non-ionic surfactant chosen from fatty alcohol polyethylene glycol ethers and fatty alcohol polypropylene glycol ethers, and mixtures thereof, and of at least one polysaccharide in water-soluble form. It also relates to a method for preparing this composition. It also relates to a stable dispersion of liposomes that can be used for the preparation of the aqueous phase of this composition.

Priority: FR20070006749 Applic. Date: 2007-09-26

Inventor: ALARD VALERIE [FR]; QUILES DOMINIQUE [FR]; DUMAS MARC [FR]; PERRIER ERIC [FR]


Application No.: US20090098173A1  Published: 16/Apr/2009

Title: TOPICAL PAIN RELIEF PRODUCT

Applicant/Assignee:

Application No.: 12/249147   Filing Date: 10/Oct/2008

Abstract:The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that provides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.

Priority: US20070979222P Applic. Date: 2007-10-11

Inventor: ROBINSON RONNI L [US]; WYNN DAVID W [US]


Application No.: US20090099157A1  Published: 16/Apr/2009

Title: TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S

Applicant/Assignee:

Application No.: 12/031551   Filing Date: 14/Feb/2008

Abstract:Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Priority: US20070889976P Applic. Date: 2007-02-15

Inventor: AMERIKS MICHAEL K [US]; ARIENTI KRISTEN L [US]; EDWARDS JAMES P [US]; GRICE CHERYL A [US]; JONES TODD K [US]; LEE-DUTRA ALICE [US]; LIU JING [US]; MANI NEELAKANDHA S [US]; NEFF DANIELLE K [US]; WICKBOLDT ALVAH T [US]; WIENER JOHN J M [US]


Application No.: US20090099500A1  Published: 16/Apr/2009

Title: MULTI-FUNCTION ELECTRODE AND USES THEREOF

Applicant/Assignee:

Application No.: 12/280078   Filing Date: 28/Feb/2007

Abstract:The present invention is of an electrode comprising an electrode substrate base layer and a plurality of layers of insoluble pole electroactive substance disposed on the electrode substrate base layer, wherein each of the plurality of layers of insoluble pole electroactive substance is configured to facilitate a treatment of a condition. Further, the present invention is of use of the electrode in a currant generating treatment device.

Priority: US20060776948P Applic. Date: 2006-02-28; WO2007IL00265 Applic. Date: 2007-02-28

Inventor: NITZAN ZVI [IL]; MOSHKOVICH MORDECHAY [IL]; LEVY SHLOMO [IL]


Application No.: US20090104116A1  Published: 23/Apr/2009

Title: COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF

Applicant/Assignee: JERINI AG

Application No.: 12/162798   Filing Date: 31/Jan/2007

Abstract:The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene

Psi is a radical of formula (II), R2 is a hydrophobic moiety

and G is a radical containing one or more moieties selected from the group consisting of NH, OH and a basic moiety. The compounds are inhibitors of integrins, especially antagonists of the fibronectin receptor alpha5beta1, useful as anti-angiogenic agents.

Priority: EP20060002005 Applic. Date: 2006-01-31; WO2007EP00832 Applic. Date: 2007-01-31

Inventor: ZISCHINSKY GUNTER [DE]; STRAGIES ROLAND [DE]; OSTERKAMP FRANK [DE]; SCHARN DIRK [DE]; HUMMEL GERD [DE]; KALKHOF HOLGER [DE]; ZAHN GRIT [DE]; VOSSMEYER DOERTE [DE]; CHRISTNER-ALBRECHT CLAUDIA [DE]; REINEKE ULRICH [DE]


Application No.: US20090104129A1  Published: 23/Apr/2009

Title: Skin care compositions

Applicant/Assignee:

Application No.: 12/002165   Filing Date: 14/Dec/2007

Abstract:The present invention relates to a skin care composition comprising at least two oil phases dispersed in a continuous aqueous phase comprising a thickening agent, wherein a first oil phase of the oil phases has different composition from the other oil phase, and wherein the composition contains an emulsifier no more than 1.0%. The present invention also relates to a method of preparing a skin care composition comprising dispersing a first oil phase in a continuous aqueous phase comprising a thickening agent

and dispersing a second oil phase in the continuous aqueous phase

wherein composition of said first oil phase differs from composition of said second oil phase, and wherein the composition contains an emulsifier no more than 1.0%.

Priority: US20060875146P Applic. Date: 2006-12-15

Inventor: CHEN MINGHUA [JP]; YUYAMA ETSUKO [JP]; MAH STANLEY PAK-LAP [CN]; TANNER PAUL ROBERT [US]


Application No.: US20090104130A1  Published: 23/Apr/2009

Title: COMPOSITIONS COMPRISING ORGANIC AND INORGANIC PHOSPHORS FOR CONVERTING ELECTROMAGNETIC RADIATION AND METHODS FOR USING THE SAME

Applicant/Assignee:

Application No.: 12/104047   Filing Date: 16/Apr/2008

Abstract:There is disclosed a topical composition comprising at least one organic and/or inorganic phosphor in a physiologically acceptable medium, wherein the phosphor(s) is present in an amount effective to convert electromagnetic radiation of an initial frequency to a different frequency. In one embodiment, the phosphors convert the initial radiation frequency, such as infrared or visible light, to a higher frequency, such as ultraviolet (UV) radiation. In another embodiment, the phosphors convert the initial radiation from a higher frequency, such as UV radiation, to a lower frequency, such as infrared or visible light. Methods of treating keratinous material, such as the skin, hair, or lips, using the disclosed compositions are also disclosed.

Priority: US20070911962P Applic. Date: 2007-04-16

Inventor: BERNSTEIN ERIC F [US]; BELL HOWARD Y [US]; BELOV VALERY [US]


Application No.: US20090104131A1  Published: 23/Apr/2009

Title: Topical anti-inflammatory compositions comprising O/W emulsions containing pro-penetrating glycols

Applicant/Assignee: GALDERMA S.A

Application No.: 12/232304   Filing Date: 15/Sep/2008

Abstract:Topically applicable compositions in the form of oil-in-water (O/W) emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable emulsifying system and at least one active agent of the family of steroidal anti-inflammatory agents, and are useful e.g., for the treatment of psoriasis.

Priority: FR20060002283 Applic. Date: 2006-03-15; WO2007FR50925 Applic. Date: 2007-03-14

Inventor: SEGURA-ORSONI SANDRINE [FR]; ROUMEC SOPHIE [FR]


Application No.: US20090104132A1  Published: 23/Apr/2009

Title: Topical anti-inflammatory compositions comprising O/W emulsions containing pro-penetrating glycols

Applicant/Assignee: GALDERMA S.A

Application No.: 12/232305   Filing Date: 15/Sep/2008

Abstract:Topically applicable compositions in the form of oil-in-water emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable gelling agent and at least one active agent of the family of steroidal anti-inflammatory agents and are useful, e.g., for the treatment of psoriasis.

Priority: FR20060002284 Applic. Date: 2006-03-15; WO2007FR50927 Applic. Date: 2007-03-14

Inventor: SEGURA-ORSONI SANDRINE [FR]; ROUMEC SOPHIE [FR]


Application No.: US20090104197A1  Published: 23/Apr/2009

Title: vWFA and/or ANT_IG Domain Containing Proteins

Applicant/Assignee: ARES TRADING S.A

Application No.: 11/718183   Filing Date: 28/Oct/2005

Abstract:This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Priority: GB20040023974 Applic. Date: 2004-10-28; WO2005GB04191 Applic. Date: 2005-10-28

Inventor: DAVIES MARK DOUGLAS [GB]; MICHALOVICH DAVID [GB]; YORKE MELANIE [CH]; POWER CHRISTINE [FR]


Application No.: US20090104254A1  Published: 23/Apr/2009

Title: Controlled Release Hydrogels

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 11/793566   Filing Date: 22/Dec/2005

Abstract:Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.

Priority: US20040638552P Applic. Date: 2004-12-22; WO2005US46891 Applic. Date: 2005-12-22

Inventor: SINKO PATRICK J [US]; STEIN STANLEY [US]; LALLOO ANITA [US]


Application No.: US20090105191A1  Published: 23/Apr/2009

Title: Pharmaceutical and Dermatocosmetic Compositions Comprising Extract of Durio Zibenthinus

Applicant/Assignee:

Application No.: 12/085907   Filing Date: 04/Dec/2006

Abstract:The present invention relates to dermatocosmetic and pharmaceutical compositions comprising compounds obtained from Durio zibethinus and their use in increasing phase angle and reducing the signs and appearance of photoaging and biological aging.

Priority: US20050741466P Applic. Date: 2005-12-02; WO2006US46138 Applic. Date: 2006-12-04

Inventor: MURAD HOWARD [US]


Application No.: US20090105260A1  Published: 23/Apr/2009

Title: Molecules to Enhance Percutaneous Delivery and Methods for Discovery Therefor

Applicant/Assignee:

Application No.: 11/883606   Filing Date: 17/Jan/2006

Abstract:An IR spectroscopic technique provides methods for measuring the irritation potential of a formulation and to assess the ability of molecules to enhance the permeability of substances into and through skin using samples comprising stratum corneum. Molecules are screened for their performance as chemical penetration enhancers using a unique in silico procedure that may be applied iteratively in an attempt to generate molecules showing successively higher performance. Both the irritation potential and the ability of the molecule to enhance penetration are considered in the in silico approach. The invention provides specific molecules that may be used in topical or transdermal formulations to improve the delivery of actives. The structures of compounds of the invention include: Formulas (I), (II), (III), (IV), (V), (IV) and analogs thereof.

Priority: US20050655839P Applic. Date: 2005-02-23; WO2006US01964 Applic. Date: 2006-01-17

Inventor: MITRAGOTRI SAMIR [US]; KARANDE PANKAJ [US]; JAIN AMIT K [US]


Application No.: US20090110649A1  Published: 30/Apr/2009

Title: ANTIPRURITIC COSMETIC AND DERMATOLOGICAL PREPARATIONS

Applicant/Assignee: BEIERSDORF AG

Application No.: 12/347241   Filing Date: 31/Dec/2008

Abstract:A topical cosmetic or dermatological preparation which is effective for treating a pruritic condition, is present as a non-ionic O/W emulsion, and comprises water, one or more oil phases, PEG 12 cetearylether and/or PEG 40 monostearate, polidocanol, menthol, and one or more O/W emulsifiers or co-emulsifiers.

Priority: DE20011058199 Applic. Date: 2001-11-27; US2002-172241 Applic. Date: 2002-06-14

Inventor: ZELLE DAGMAR [DE]; FILBRY ALEXANDER [DE]; KROEPKE RAINER [DE]


Application No.: US20090110650A1  Published: 30/Apr/2009

Title: Photoprotective Composition and Screening Agents for Said Composition

Applicant/Assignee: L'OREAL

Application No.: 11/988292   Filing Date: 12/Jul/2006

Abstract:The present invention concerns a photoprotective composition comprising at least one interferential screening agent screening UVA and/or UVB.

Priority: FR20050052211 Applic. Date: 2005-07-13; US20050708761P Applic. Date: 2005-08-17; WO2006IB52361 Applic. Date: 2006-07-12

Inventor: CANDAU DIDIER [FR]


Application No.: US20090110704A1  Published: 30/Apr/2009

Title: COSMETIC COMPOSITION BASED ON A MAGNETIC OR MAGNETISABLE MATERIAL, THE PREPARATION THEREOF AND USE THEREOF FOR CLEANSING THE EPIDERMIS

Applicant/Assignee: DERMOPHISIOLOGIQUE S.R.L

Application No.: 12/259724   Filing Date: 28/Oct/2008

Abstract:The present invention relates to a cosmetic composition based on a magnetic or magnetisable material, the preparation thereof and use thereof for surface and deep cleansing of the epidermis. Said cosmetic composition has revealed to be particularly useful for preparing a mask for cleansing the epidermis of the face, breast, hands and body and, simultaneously, for maintaining the aesthetic appearance and functional efficiency thereof.

Priority: IT2007MI02098 Applic. Date: 2007-10-30

Inventor: REDAELLI CAROLINA [IT]


Application No.: US20090110731A1  Published: 30/Apr/2009

Title: Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same

Applicant/Assignee: CELONOVA BIOSCIENCES, INC

Application No.: 11/928722   Filing Date: 30/Oct/2007

Abstract:Particles are provided for use in restorative procedures to treat and/or retard alopecia The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired scalp colors. Moreover, such particles may be loaded to provide localized treatment with an active component agent directed at restoration of normal function and hair production within the hair follicle.

Priority:

Inventor: FRITZ OLAF [DE]; FRITZ ULF [DE]; WOJCIK RONALD [US]; GASKINS JR RALPH E [US]


Application No.: US20090110734A1  Published: 30/Apr/2009

Title: QUATERNISED AMMONIUM CYCLODEXTRIN COMPOUNDS

Applicant/Assignee:

Application No.: 12/238473   Filing Date: 26/Sep/2008

Abstract:Use of a compound of formula (I): wherein the symbol represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups

n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound

h is 0 or 1

R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene

R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl

xm- is a m-fold negatively charged anion

m is an integer being equal or greater than 1

and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

Priority: EP20020013074 Applic. Date: 2002-06-13; EP20020028554 Applic. Date: 2002-12-20; US2004-516247 Applic. Date: 2004-11-30; WO2003EP06192 Applic. Date: 2003-06-12

Inventor: KIS GEORG LUDWIG [CH]; SCHOCH CHRISTIAN [CH]; SZEJTLI JOZSEF [HU]


Application No.: US20090111731A1  Published: 30/Apr/2009

Title: NOVEL TOPICAL APPLICATION AGENTS AGAINST MIMIC AND AGE-RELATED WRINKLES

Applicant/Assignee: PENTAPHARM AG

Application No.: 11/718496   Filing Date: 01/Nov/2005

Abstract:The compounds of formula (I) wherein X represents a bond or NH-CH(C-O)-(CH2)3+n-NH-R5, n represents 0, 1 or 2, R1, R4 and R5-independently from each other-represent hydrogen, possibly substituted C1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium, R2 represents hydrogen or possibly substituted C1-C6-alkyl or R1 and R2 together with the residue to which they are bound represent a 5- to 7-membered, saturated ring, R3 represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C6-alkylamino, possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1-C6-alkoxy or possibly substituted heteroaryl-C1-C6-alkoxy, and R6 represents hydrogen or, when n is 1, also amino or together with R1 and the residue to which R6 and R1 are bound a 5- to 7-membered, saturated ring, as well as their physiologically acceptable salts are new. They can be manufactured according to common methods and processed to topically applicable compositions that are appropriate for treating mimic and age-related wrinkles in human skin.

Priority: CH20040001809 Applic. Date: 2004-11-02; WO2005CH00638 Applic. Date: 2005-11-01

Inventor: IMFELD DOMINIC [CH]; ZIEGLER HUGO [CH]; WIKSTROEM PETER [CH]


Application No.: US20090111738A1  Published: 30/Apr/2009

Title: FIBRONECTIN POLYPEPTIDES AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/089291   Filing Date: 04/Oct/2006

Abstract:Described herein are fragments of fibronectin and variants thereof that bind growth factors. Compositions containing such a fragment of fibronectin are therefore useful in sequestering growth factors, and complexes containing both a FN fragment and a bound, active growth factor can be used to deliver growth factors to a patient (e.g., to a wound on the patient's skin).

Priority: US20050723496P Applic. Date: 2005-10-04; WO2006US38778 Applic. Date: 2006-10-04

Inventor: CLARK RICHARD A [US]; REN XIANG-DONG [US]; LIN FUBAO [US]


Application No.: US20090111780A1  Published: 30/Apr/2009

Title: COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION

Applicant/Assignee: EVERETT LABORATORIES, INC

Application No.: 11/932191   Filing Date: 31/Oct/2007

Abstract:The present invention relates to compositions and methods for treatment of ear infections and inflammation. Specifically, the method involves administering to a patient a composition containing an antibacterial, an anti-inflammatory, and an anti-septic that is substantially free of pramoxine to treat the occurrence or negative effects of otic infection and inflammation.

Priority:

Inventor: GIORDANO JOHN A [US]


Application No.: US20090111784A1  Published: 30/Apr/2009

Title: MEDICATION AGAINST BREAST CANCER AND RELATED DISEASES

Applicant/Assignee:

Application No.: 12/300503   Filing Date: 11/May/2007

Abstract:The present invention relates to novel uses of a steroid compound, which specifically binds to the androgen receptor (AR) but which is not metabolized by aromatase to a process for their preparation, to pharmaceutical compositions containing them, and to the use of said compounds for the prophylaxis and/or treatment of hormone-dependent or hormone receptor regulated cancers in mammals.

Priority: EP20060009894 Applic. Date: 2006-05-12; US20060747124P Applic. Date: 2006-05-12; WO2007EP04221 Applic. Date: 2007-05-11

Inventor: TEICHMANN ALEXANDER TOBIAS [DE]


Application No.: US20090111794A1  Published: 30/Apr/2009

Title: Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase

Applicant/Assignee:

Application No.: 12/291018   Filing Date: 30/Oct/2008

Abstract:Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

Priority: US20070984126P Applic. Date: 2007-10-31

Inventor: BACANI GENESIS M [US]; BEMBENEK SCOTT D [US]; ECCLES WENDY [US]; EDWARDS JAMES P [US]; EPPERSON MATTHEW T [US]; GOMEZ LAURENT [US]; GRICE CHERYL A [US]; KEARNEY AARON M [US]; LANDRY-BAYLE ADRIENNE M [US]; LEE-DUTRA ALICE [US]; MCCLURE KELLY J [US]; MIRZADEGAN TARANEH [US]; SANTILLAN JR ALEJANDRO [US]


Application No.: US20090111866A1  Published: 30/Apr/2009

Title: Novel Compounds

Applicant/Assignee: GLAXO WELLCOME HOUSE

Application No.: 12/226372   Filing Date: 18/Apr/2007

Abstract:The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.

Priority: GB20060007840 Applic. Date: 2006-04-20; GB20060020382 Applic. Date: 2006-10-13; GB20070006515 Applic. Date: 2007-04-03; GB20070006516 Applic. Date: 2007-04-03; WO2007EP53795 Applic. Date: 2007-04-18

Inventor: BIGGADIKE KEITH [GB]; COOPER ANTHONY WILLIAM JAMES [GB]; HOUSE DAVID [GB]; MCLAY IAIN MCFARLANE [GB]; WOOLLAM GRAHAME ROBERT [GB]


Application No.: US20090112141A1  Published: 30/Apr/2009

Title: METHOD AND APPARATUS FOR PROVIDING A MEDICAL DRESSING

Applicant/Assignee:

Application No.: 11/931766   Filing Date: 31/Oct/2007

Abstract:The invention relates to a medical dressing having an elastic material for encircling about a body member, an elastomer attached to the elastic material and adapted to directly contact a wound on the body member, and where the elastomer includes an additive for treating the wound, wherein the elastic material applies compressive force to the elastomer and wound as the elastic material encircles the body member.

Priority:

Inventor: DERR MICHAEL J [US]


Application No.: US20090117060A1  Published: 07/May/2009

Title: Cosmetic Process for the Treatment of the Skin with Sun-Protection Products and Sun-Protection Products Combination

Applicant/Assignee: COTY B.V

Application No.: 11/568092   Filing Date: 14/Apr/2005

Abstract:The invention relates to a cosmetic method, whereby skin is treated with various sun products, and to a sun product combination. The inventive method is characterized by applying, prior to intensive exposure of the skin to UV radiation, a pre-sun product, then a sun product and finally repeatedly applying an after-sun product. The pre-sun product comprises a radical interceptor, the combination caffeine/complex amino acid salt, the combination photolyase/UV endonuclease and an algae extract of Corallina officinalis. The sun product comprises a UV filter combination of UVA and UVB filters having at least 3% by weight of UVA filter. The after-sun product comprises components similar to those used for the pre-sun product, the content of the radical interceptor and the enzyme photolyase being by 50 to 90% by weight lower, the content of the enzyme UV endonuclease being by 50 to 90% by weight higher, and the algae extract being replaced by a cooling plant extract.

Priority: DE200410020060 Applic. Date: 2004-04-20; WO2005EP04150 Applic. Date: 2005-04-14

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Application No.: US20090117061A1  Published: 07/May/2009

Title: SKIN CARE PRODUCTS CONTAINING MULTIPLE ENHANCERS

Applicant/Assignee:

Application No.: 12/243665   Filing Date: 01/Oct/2008

Abstract:The present invention provides a skin care product comprising at least two enhancers and at least one skin care ingredient, wherein the at least two enhancers are selected from cyclodextrin, pentasodium pentetate, phytic acid, potassium citrate, sodium citrate, potassium gluconate and sodium gluconate.

Priority: US20070976792P Applic. Date: 2007-10-01

Inventor: GROSS DENNIS F [US]


Application No.: US20090117068A1  Published: 07/May/2009

Title: COSMETIC COMPOSITIONS

Applicant/Assignee: RECKITT & BENCKISER (UK) LIMITED

Application No.: 11/991676   Filing Date: 18/Sep/2006

Abstract:The present invention relates to a solid cosmetic composition which includes a soap and/or a non-soap surfactant, a hair modification active and/or skin enhancing agent, and at least one silicone and/or mineral oil.

Priority: GB20050018934 Applic. Date: 2005-09-16; GB20060002109 Applic. Date: 2006-02-02; WO2006GB03479 Applic. Date: 2006-09-18

Inventor: ELLIS PAUL [GB]; HEESON TRACEY [GB]; THOMAS MARK [US]


Application No.: US20090117074A1  Published: 07/May/2009

Title: Sulfonylpyrroles as Histone Deacetylase Inhibitors

Applicant/Assignee: NYCOMED GMBH

Application No.: 11/887268   Filing Date: 07/Apr/2006

Abstract:The invention relates to compounds of formula (I) which are effective inhibitors of histone deacetylases.

Priority: EP20050102750 Applic. Date: 2005-04-07; WO2006EP03171 Applic. Date: 2006-04-07

Inventor: MAIER THOMAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [DE]; ZIMMERMANN ASTRID [DE]; DULLWEBER FRANK [DE]; GEKELER VOLKER [DE]


Application No.: US20090117093A1  Published: 07/May/2009

Title: GRANULYSIN PEPTIDES AND METHODS OF USE THEREOF

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 11/815650   Filing Date: 14/Feb/2006

Abstract:Granulysin peptides are small antimicrobial agents with potent activity. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient for exfoliation, e.g. for the treatment of skin lesions.

Priority: US20050653232P Applic. Date: 2005-02-14; WO2006US05306 Applic. Date: 2006-02-14

Inventor: KIM JENNY J [US]


Application No.: US20090117158A1  Published: 07/May/2009

Title: Transdermal sustained release drug delivery

Applicant/Assignee:

Application No.: 12/288760   Filing Date: 23/Oct/2008

Abstract:Provided herein are microprojections and microprojection arrays wherein a microprojection is coated with at least two layers. One layer comprises a biologically active agent, for example, a PTH agent and optionally other excipients. Another layer, which is generally, initially devoid of active agent comprises a polymer or a mix of polymers to provide controlled release, for example sustained release, of the biologically active agent contained in the first layer. Microprojections coated with multiple layers, some layers containing a biologically active agent and other layers containing a polymer for controlled release are also contemplated herein.

Priority: US20070982127P Applic. Date: 2007-10-23

Inventor: AMERI MAHMOUD [US]; MAA YUH-FUN [US]


Application No.: US20090117164A1  Published: 07/May/2009

Title: Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers

Applicant/Assignee: QUICK-MED TECHNOLOGIES, INC

Application No.: 12/350784   Filing Date: 08/Jan/2009

Abstract:An alcohol- or glycol-soluble, water-insoluble, disinfectant composition and a method of using the same for disinfecting and for providing a prolonged antimicrobial property to a variety of surfaces, including skin. The composition comprises at least one alcohol or glycol and an antimicrobial polymer that is capable of imparting an antimicrobial property to a surface without the use of a metal or a metal-containing compound. The composition is applied to a surface and allowed to evaporate leaving a coating of antimicrobial polymer. Alternatively, the composition is incorporated into or within the substrate.

Priority: US2008-064487 Applic. Date: 2008-02-22; WO2006US32954 Applic. Date: 2006-08-22; US20080019798P Applic. Date: 2008-01-08; US20060806196P Applic. Date: 2006-06-29; US20050710128P Applic. Date: 2005-08-22

Inventor: TOREKI WILLIAM [US]; OLDERMAN GERALD [US]


Application No.: US20090117174A1  Published: 07/May/2009

Title: MODIFIED SORBITAN SILOXANE COMPOSITIONS AND USE THEREOF

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/934567   Filing Date: 02/Nov/2007

Abstract:The present disclosure generally relates to personal care compositions and wipes. More particularly, the disclosure relates to compositions and wipes for imparting a perceivable aesthetic feel to the skin of a user. To achieve the perceivable aesthetic feel, a modified sorbitan siloxane is incorporated into the compositions and wipes.

Priority:

Inventor: CUNNINGHAM COREY [US]; WENZEL SCOTT W [US]; LANGOLF BRIAN M [US]; KIEFFER PHILIP E [US]; DECKER CHRISTOPHER V [US]


Application No.: US20090118166A1  Published: 07/May/2009

Title: Conditioned Decellularized Native Tissues for Tissue Restoration

Applicant/Assignee:

Application No.: 12/351757   Filing Date: 09/Jan/2009

Abstract:The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. The composition is conditioned by culturing cells on the matrix and/or by exposing the cultured cells or matrix to one or more stressors.

Priority: US2004-876299 Applic. Date: 2004-06-24; US20030482480P Applic. Date: 2003-06-25; US20040538385P Applic. Date: 2004-01-21

Inventor: BADYLAK STEPHEN F [US]


Application No.: US20090118298A1  Published: 07/May/2009

Title: Octahydropentalene compounds as chemokine receptor antagonists

Applicant/Assignee:

Application No.: 12/284758   Filing Date: 25/Sep/2008

Abstract:The present invention is directed to novel compounds of Formula (I) pharmaceutically acceptable salts thereof, pro-drugs thereof, biologically active metabolites thereof, isomers thereof or stereoisomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, osteoarthritis, multiple sclerosis and asthma.

Priority: US20070995148P Applic. Date: 2007-09-25

Inventor: GEORGE DAWN M [US]; WANG LU [US]; LI BIQIN [US]; ERICSSON ANNA M [US]; ANSELL GRAHAM K [US]


Application No.: US20090118324A1  Published: 07/May/2009

Title: MAPK/ERK KINASE INHIBITORS

Applicant/Assignee:

Application No.: 12/050139   Filing Date: 17/Mar/2008

Abstract:Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20070895617P Applic. Date: 2007-03-19

Inventor: DONG QING [US]; KANOUNL TOUFIKO [US]; WALLACE MICHAEL B [US]


Application No.: US20090123370A1  Published: 14/May/2009

Title: ALPHAVBETA6 PEPTIDE LIGANDS AND THEIR USES

Applicant/Assignee:

Application No.: 12/088998   Filing Date: 03/Oct/2006

Abstract:AVbeta6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AVbeta6 mediated diseases.

Priority: GB20050020068 Applic. Date: 2005-10-03; WO2006GB03673 Applic. Date: 2006-10-03

Inventor: HOWARD MARK J [GB]; DICARA DANIELLE [GB]; MARSHALL JOHN F [GB]


Application No.: US20090123390A1  Published: 14/May/2009

Title: COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL INFLAMMATION

Applicant/Assignee: MERITAGE PHARMA, INC

Application No.: 12/269832   Filing Date: 12/Nov/2008

Abstract:Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US20080035348P Applic. Date: 2008-03-10; US20080054103P Applic. Date: 2008-05-16; US20080054105P Applic. Date: 2008-05-16; US20070012012P Applic. Date: 2007-12-06; US20080054107P Applic. Date: 2008-05-16; US20070015998P Applic. Date: 2007-12-21; US20080019818P Applic. Date: 2008-01-08; US20080034941P Applic. Date: 2008-03-07; US20080054106P Applic. Date: 2008-05-16; US20080090658P Applic. Date: 2008-08-21; US20070987720P Applic. Date: 2007-11-13; US20080054104P Applic. Date: 2008-05-16

Inventor: HILL MALCOLM [US]


Application No.: US20090123406A1  Published: 14/May/2009

Title: ORGANIC THERAPEUTIC AND COSMETIC PREPARATION

Applicant/Assignee:

Application No.: 12/325181   Filing Date: 29/Nov/2008

Abstract:A mixture of an aqueous solution, essential oils and mechanically extracted Phaeophyte kelp cytoplasm results in an emulsion with cosmetic and therapeutic properties. The preparation may be used on human and animal hair or skin. The moisturizing properties of the kelp cytoplasm provide the aqueous solution to the hair (keratin) which is absorbed, causing the hair to swell, and become heavier and more pliable. The natural oxidation agent preserves the mixture as well as providing a fresh oxygen in a spray when used. The alginate gels and oils in the emulsion coat the hair strands to reduce breakage and splitting and add weight to the strand. The preparation dries with gel capsules, which release moisture over time for a long-lasting effect. The preparation also contains, and may be supplemented with fuciodans, iodine, phlorotannins which reduce inflammation, prevent scaly skin, and act as an antibiotic, respectively, on dry chapped skin. The preparation seals off the cracks from the environment while trapping moisture pockets. This provides an environment conducive for healing.

Priority: US2006-638122 Applic. Date: 2006-12-13; US20050597624P Applic. Date: 2005-12-13

Inventor: PHEIFFER STEPHEN [US]


Application No.: US20090123407A1  Published: 14/May/2009

Title: MONO-, DI- AND POLYOL PHOSPHATE ESTERS IN PERSONAL CARE FORMULATIONS

Applicant/Assignee: RHODIA INC

Application No.: 12/349401   Filing Date: 06/Jan/2009

Abstract:A hydrophilized personal care formulation, which can be in the form of a hand or body soap (liquid or bar), lipstick, body wash, makeup remover, skin cleaner, hair conditioner, skin or hair moisturizer. The formulation employs an organophosphorus material or a mixture of an organophosphorus material, for example, mono-, di-, and polyol phosphate esters.

Priority: US2008-137589 Applic. Date: 2008-06-12; US20070943487P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES [SG]; HOUGH LAWRENCE ALAN [US]; REIERSON ROBERT LEE [US]


Application No.: US20090123420A1  Published: 14/May/2009

Title: Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase

Applicant/Assignee: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC

Application No.: 12/175518   Filing Date: 18/Jul/2008

Abstract:The present invention provides improved treatment methods by the administration of the non-physiologic D-isomer of an IDO inhibitor.

Priority: US2004-780150 Applic. Date: 2004-02-17; US20030459489P Applic. Date: 2003-04-01; US20040538647P Applic. Date: 2004-01-22

Inventor: MUNN DAVID [US]; MELLOR ANDREW [US]


Application No.: US20090123467A1  Published: 14/May/2009

Title: Polypeptide-Nucleic Acid Conjugate for Immunoprophylaxis or Immunotherapy for Neoplastic or Infectious Disorders

Applicant/Assignee: THE JOHNS HOPKINS UNIVERSITY

Application No.: 12/184246   Filing Date: 31/Jul/2008

Abstract:The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of infectious disease, neoplastic diseases or other disorders.

Priority: US20070007895P Applic. Date: 2007-07-31; US20080022173P Applic. Date: 2008-01-18

Inventor: BEDI ATUL [US]; RAVI RAJANI [US]; LI SHULIN [US]


Application No.: US20090123504A1  Published: 14/May/2009

Title: OLIVE OIL FORMULATION FOR PAIN RELIEF

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/938596   Filing Date: 12/Nov/2007

Abstract:The present disclosure generally relates to methods and compositions for reducing inflammation and/or pain, and more particularly, to compositions comprising an NSAID and oleocanthal and/or a related compound. The compositions are particularly suitable for topical delivery and may be used to relieve the effects of arthritis.

Priority:

Inventor: FELDKAMP JOSEPH R [US]; SERRA LAURA [US]; JOSEPH PIERRE [US]; CUNNINGHAM COREY [US]


Application No.: US20090123550A1  Published: 14/May/2009

Title: CORTICOSTEROID COMPOSITIONS

Applicant/Assignee: MERITAGE PHARMA, INC

Application No.: 12/269816   Filing Date: 12/Nov/2008

Abstract:Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US20080035348P Applic. Date: 2008-03-10; US20080054103P Applic. Date: 2008-05-16; US20080054105P Applic. Date: 2008-05-16; US20070012012P Applic. Date: 2007-12-06; US20080054107P Applic. Date: 2008-05-16; US20070015998P Applic. Date: 2007-12-21; US20080019818P Applic. Date: 2008-01-08; US20080034941P Applic. Date: 2008-03-07; US20080054106P Applic. Date: 2008-05-16; US20080090658P Applic. Date: 2008-08-21; US20070987720P Applic. Date: 2007-11-13; US20080054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE [US]; HILL MALCOLM [US]; LICALSI CYNTHIA [US]; DESHMUKH HEMANT [US]; JOHNSON KEITH [US]


Application No.: US20090123551A1  Published: 14/May/2009

Title: GASTROINTESTINAL DELIVERY SYSTEMS

Applicant/Assignee: MERITAGE PHARMA, INC

Application No.: 12/269821   Filing Date: 12/Nov/2008

Abstract:Provided herein are compositions suitable for the delivery of therapeutic agents to the gastrointestinal tract. Also provided herein are methods for treating, preventing or alleviating disorders of the gastrointestinal tract, for example, those involving the esophagus, by orally administering compositions described herein.

Priority: US20080054105P Applic. Date: 2008-05-16; US20070012012P Applic. Date: 2007-12-06; US20080054107P Applic. Date: 2008-05-16; US20070015998P Applic. Date: 2007-12-21; US20080019818P Applic. Date: 2008-01-08; US20080034941P Applic. Date: 2008-03-07; US20080054106P Applic. Date: 2008-05-16; US20080090658P Applic. Date: 2008-08-21; US20070987720P Applic. Date: 2007-11-13; US20080054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE [US]; HILL MALCOLM [US]


Application No.: US20090123572A1  Published: 14/May/2009

Title: Method and Pharmaceutical Composition for Treating Psoriasis, Squamous Cell Carcinoma and/or Parakeratosis by Inhibiting Expression of Squamous Cell Carcinoma-Related Antigen

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 11/886475   Filing Date: 22/Sep/2005

Abstract:In a first aspect thereof, the present invention provides a method for treatment and/or prevention of a disease selected from the group consisting of psoriasis and squamous cell carcinoma by inhibiting the expression of squamous cell carcinoma antigen (SCCA) by cells. In another aspect thereof, the present invention provides a method for screening for substances that inhibit epidermal parakeratosis, wherein the activity of a candidate substance that inhibits cysteine protease inhibitory activity possessed by squamous cell carcinoma antigen 1 (SCCA-1) is used as an indicator.

Priority: JP20050080566 Applic. Date: 2005-03-18; WO2005JP18074 Applic. Date: 2005-09-22

Inventor: HIBINO TOSHIHIKO [JP]; NAKANISHI JOTARO [JP]; KATAGIRI CHIKA [JP]


Application No.: US20090123573A1  Published: 14/May/2009

Title: ADMIXTURE OF EXTRACTS OF PLANTS OF THE GENUS ROSMARINUS AND CAROTENOIDS FOR TREATING CUTANEOUS SYMPTOMS OF AGING

Applicant/Assignee: SOCIETE L'OREAL S.A NESTEC S.A

Application No.: 12/121914   Filing Date: 16/May/2008

Abstract:Intimate admixtures of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus are well suited for treating the undesirable cutaneous signs of skin aging, in particular the degradation of the skin and/or of the mucous membranes by inhibiting the activity and/or the expression of collagenases and by increasing the synthesis of collagen.

Priority: FR20000013757 Applic. Date: 2000-10-26; US2003-424751 Applic. Date: 2003-04-28; WO2001FR03314 Applic. Date: 2001-10-25

Inventor: BRETON LIONEL [FR]; BAUR MARKUS [DE]


Application No.: US20090123576A1  Published: 14/May/2009

Title: ACTIVE SUBSTANCE COMBINATIONS OF ANISE FRUIT EXTRACT AND WHITE TEA EXTRACT

Applicant/Assignee: BEIERSDORF AG

Application No.: 12/258934   Filing Date: 27/Oct/2008

Abstract:An active substance combination which comprises anise fruit extract and white tea extract and a cosmetic preparation comprising same. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: DE200710052536 Applic. Date: 2007-11-01

Inventor: KROEPKE RAINER [DE]; FAENGER SABINE [DE]; MUMMERT CHRISTOPHER [DE]; SCHULZ JENS [DE]


Application No.: US20090123582A1  Published: 14/May/2009

Title: Ameliorating Agent for Metabolic Syndrome

Applicant/Assignee:

Application No.: 12/225561   Filing Date: 23/Mar/2007

Abstract:The object is to provide a food-derived effective ingredient which can promote the reduction in accumulated fats or the like. Disclosed is a body fat reduction-promoting agent, a leptin production-promoting agent, an anorexigenic agent, a PAI-1 production-suppressing agent or an anti-thrombotic agent, each comprising an extract from a chestnut astringent skin as an active ingredient. The extract from a chestnut astringent skin, which is a natural component, can be used as an extremely safe body fat reduction-promoting agent, leptin production-promoting agent, anorexigenic agent, PAI-1 production-suppressing agent or anti-thrombotic agent. Particularly, the body fat reduction-promoting agent can reduce an accumulated visceral fat and therefore can directly prevent obesity.

Priority: JP20060083003 Applic. Date: 2006-03-24; WO2007JP55987 Applic. Date: 2007-03-23

Inventor: KUWAHARA AKIKO [JP]; NAKANISHI AYAKO [JP]; SUDA KAZUMA [JP]


Application No.: US20090124525A1  Published: 14/May/2009

Title: HARD SURFACE CLEANING COMPOSITION WITH HYDROPHILIZING AGENT AND METHOD FOR CLEANING HARD SURFACES

Applicant/Assignee: RHODIA INC

Application No.: 12/349490   Filing Date: 06/Jan/2009

Abstract:A composition for cleaning or rinsing hard surfaces in an aqueous or aqueous/alcoholic medium including at least one organophosphorus material for contributing to said surfaces antideposition and/or antiadhesion properties with regard to soiling substances capable of being deposited on the surfaces.

Priority: US2008-137738 Applic. Date: 2008-06-12; US20070943517P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES [SG]; HOUGH LAWERENCE ALAN [US]; REIERSON ROBERT LEE [US]


Application No.: US20090124546A1  Published: 14/May/2009

Title: Antimicrobially Active Peptides

Applicant/Assignee: EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKILINIKUM

Application No.: 12/043920   Filing Date: 06/Mar/2008

Abstract:An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.

Priority: DE20011029983 Applic. Date: 2001-06-13; US2003-735481 Applic. Date: 2003-12-12; WO2002EP06238 Applic. Date: 2002-06-07

Inventor: GARBE CLAUS [DE]; SCHITTEK BIRGIT [DE]


Application No.: US20090124556A1  Published: 14/May/2009

Title: Peptides Exhibiting Efficacies of Improvement in Skin Conditions or Treatment of Periodental Diseases

Applicant/Assignee:

Application No.: 12/083970   Filing Date: 24/Oct/2006

Abstract:The present invention relates to a composition for improving a skin condition or treating a periodontal disease, which comprises as an active ingredient a basic fibroblast growth factor-derived peptide. The peptides of this invention exhibit superior efficacies and much better stability and skin permeation than natural-occurring bFGF. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in skin conditions and treatment of periodontal diseases. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, cosmetics, tooth-paste and compositions for mouth cleaning and caring.

Priority: KR20050100391 Applic. Date: 2005-10-24; WO2006KR04350 Applic. Date: 2006-10-24

Inventor: CHUNG YONG JI [KR]; KIM YOUNG DEUG [KR]; KIM CHUNG RYUL [KR]


Application No.: US20090124595A1  Published: 14/May/2009

Title: MAPK/ERK KINASE INHIBITORS

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 12/267353   Filing Date: 07/Nov/2008

Abstract:Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20070987279P Applic. Date: 2007-11-12

Inventor: ADAMS MARK [US]; DONG QING [US]; KANOUNI TOUFIKE [US]; KALDOR STEPHEN W [US]; SCORAH NICHOLAS [US]; WALLACE MICHAEL B [US]


Application No.: US20090124646A1  Published: 14/May/2009

Title: SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE

Applicant/Assignee: JANSSEN PHARMACEUTICA N.V

Application No.: 11/572563   Filing Date: 25/Jul/2005

Abstract:This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity

their preparation, compositions containing them and their use as a medicine.

Priority: EP20040077172 Applic. Date: 2004-07-28; US20040592182P Applic. Date: 2004-07-29; WO2005EP53612 Applic. Date: 2005-07-25

Inventor: VERDONCK MARC GUSTAAF CELINE [BE]; ANGIBAUD PATRICK RENE [FR]; ROUX BRUNO [FR]; PILATTE ISABELLE NOELLE CONSTANCE [FR]; TEN HOLTE PETER [BE]; ARTS JANINE [BE]; VAN EMELEN KRISTOF [BE]


Application No.: US20090124693A1  Published: 14/May/2009

Title: Cosmetic Compositions Comprising Hydroxyfatty Acids

Applicant/Assignee:

Application No.: 11/990490   Filing Date: 14/Sep/2006

Abstract:The present invention is concerned with novel cosmetic or pharmaceutical compositions. More particularly, the invention is concerned with novel cosmetic or pharmaceutical compositions for treating or preventing any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as well as for the promotion of hair growth and protection from hair loss.

Priority: EP20050020779 Applic. Date: 2005-09-23; EP20050020905 Applic. Date: 2005-09-26; WO2006EP08961 Applic. Date: 2006-09-14

Inventor: BEUMER RAPHAEL [DE]


Application No.: US20090124985A1  Published: 14/May/2009

Title: SKIN TREATMENT DEVICE

Applicant/Assignee:

Application No.: 12/139093   Filing Date: 13/Jun/2008

Abstract:A personal skin polishing or microdermabrasion device having a convenient form factor with a applicator attached to a contoured housing with a handle portion. The housing contains a battery, a cordless motor and a gear box to provide an appropriate rotational velocity to the output shaft that is coupled to the applicator. The applicator may be a foam material selected to cushion the skin from excessive abrasion to the particles in a personal care composition to be used with device, and to have a porosity that will enable the foam to interact with the particles and enhance the skin polishing effect.

Priority: US20070934439P Applic. Date: 2007-06-13

Inventor: HASENOEHRL ERIK JOHN [US]; FANTA KEITH DAVID [US]; KEMP HELEN ROCHELLE [US]; PINYAYEV ALEKSEY MIKHAILOVICH [US]; MCDANIEL JOHN ANDREW [US]; VERNON PAUL JOHN EDWARD [US]; TANNER PAUL ROBERT [US]; CORTINA LINDA EVA [US]; LEPPLA NANCY LORINCZ [US]; ZIMMERMAN DEAN ARTHUR [US]


Application No.: US20090130029A1  Published: 21/May/2009

Title: GLYCEROL ETHERS VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF

Applicant/Assignee: FOAMIX LTD

Application No.: 12/275532   Filing Date: 21/Nov/2008

Abstract:The present disclosure teaches unique foamable vehicles or carriers comprising at least one glycerol ether, a stabilizer, and water

pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses.

Priority: US20070989738P Applic. Date: 2007-11-21

Inventor: TAMARKIN DOV [IL]; BESONOV ALEX [IL]


Application No.: US20090130035A1  Published: 21/May/2009

Title: STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES

Applicant/Assignee: SYMRISE GMBH & CO. KG

Application No.: 12/159866   Filing Date: 05/Jan/2007

Abstract:The present invention relates primarily to a cosmetic and/or pharmaceutical preparation comprising of consisting of one or more phenolic compounds of the formula (I) where for formula (I) it is the case that: R1, R2, R3, R4 and R5 are independently of one another hydrogen, halogen, an OH group, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, with 1, 2 or 3 different radicals from the group R1, R2, R3, R4 and R5 simultaneously representing an OH group, R6 and R7 are independently of one another hydrogen, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, n is an integer from 0 to 20 and R8 is methyl or a linear or branched alkyl having 2 or 3 C atoms, a cycloalkyl having 3, 4, 5, 6 or 7 C atoms or a phenyl and one or more compounds of the formula (II) where for formula (II) it is the case that: R9, R10, R11 and R12 independently of one another are hydrogen, methyl, an OH group or a group -O-R13 and R13 is methyl or a linear or branched alkyl having 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, and to uses of compounds of the formula (II) for stabilizing compounds of the formula (I), and also to methods of stabilizing compounds of the formula (I).

Priority: US20060756205P Applic. Date: 2006-01-05; US20060804319P Applic. Date: 2006-06-09; WO2007EP50123 Applic. Date: 2007-01-05

Inventor: LANGE SABINE [DE]; SCHMAUS GERHARD [DE]; VIELHABER GABRIELE [DE]; SCHAPER KARIN [DE]


Application No.: US20090130040A1  Published: 21/May/2009

Title: COSMETIC RINSABLE MASK TYPE COMPOSITION FOR SKIN CARE

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/281736   Filing Date: 13/Apr/2007

Abstract:The present invention relates to a cosmetic composition of rinse-off mask type for the care of the skin, for example of the face. The invention relates to a cosmetic composition of rinse-off mask type for the care of the skin, characterized in that it comprises at least one superabsorbent polymer or copolymer of water-retaining type, in the form of particles in the substantially completely hydrated state, said particles having, in the dry or nonhydrated state, a mean particle size of between 5 and 100 mum, advantageously between 20 and 50 mum, in particular between 20 and 30 mum. The composition applied to the skin provides a very refreshing effect and can be easily rinsed off after use.

Priority: FR20060003421 Applic. Date: 2006-04-14; WO2007FR51114 Applic. Date: 2007-04-13

Inventor: JONCHIERE CLAIRE [FR]


Application No.: US20090130048A1  Published: 21/May/2009

Title: Topical Composition for Treating Pain

Applicant/Assignee:

Application No.: 11/942409   Filing Date: 19/Nov/2007

Abstract:Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps

mouth guards, dental trays

needles or catheters

adult diapers

gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

Priority:

Inventor: ORONSKY BRYAN TODD [US]; ORONSKY NEIL CHARLES [US]; ORONSKY ARNOLD L [US]


Application No.: US20090130139A1  Published: 21/May/2009

Title: Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses

Applicant/Assignee:

Application No.: 12/293308   Filing Date: 27/Mar/2007

Abstract:The invention relates to a novel cosmetic active ingredient composed of a microalgae extract and arginine ferrulate, its uses for activating proteasome and the production of thioredoxin, a cosmetic composition containing it and the use of such a cosmetic composition for combating skin ageing.

Priority: FR20060002628 Applic. Date: 2006-03-27; WO2007FR00527 Applic. Date: 2007-03-27

Inventor: MEKIDECHE NICOLE [FR]


Application No.: US20090130188A1  Published: 29/Mar/2007

Title: Acrylic pressure sensitive adhesives

Applicant/Assignee: NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING COMPANY

Application No.: 11/238277   Filing Date: 29/Sep/2005

Abstract:Solution acrylic polymers suitable for dispersing drugs are particularly useful in transdermal drug delivery applications.

Priority:

Inventor: FOREMAN PAUL B [US]; LUCIANO ALLISON [US]


Application No.: US20090130190A1  Published: 21/May/2009

Title: Transdermal System for the Delivery of Sufentanil and Its Analogs

Applicant/Assignee: LABTEC GMBH

Application No.: 12/255466   Filing Date: 21/Oct/2008

Abstract:Methods and systems for the transdermal delivery of sufentanil and its analogs are described, from patches having a unique pharmacodynamic profile that can be used to treat persistent pain over extended periods and acute pain episodes of limited duration.

Priority: DE200610019293 Applic. Date: 2006-04-21; WO2007EP03498 Applic. Date: 2007-04-20

Inventor: BREITENBACH ARMIN [DE]; KLAFFENBACH PETER [DE]; LEHRKE INGO [DE]; VOLLMER ULRIKE [DE]


Application No.: US20090130227A1  Published: 21/May/2009

Title: EXTERNAL PREPARATION FOR SKIN

Applicant/Assignee:

Application No.: 11/912433   Filing Date: 27/Sep/2005

Abstract:The present invention provides an external preparation for skin which contains 5-aminolevulinic acids as active components and which is excellent in skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum

and in an ameliorating effect on skin diseases such as atopic dermatitis. An external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them

and an iron compound

as active components, is used.

Priority: JP20050131171 Applic. Date: 2005-04-28; WO2005JP17681 Applic. Date: 2005-09-27

Inventor: ITO YOSHIYASU [JP]


Application No.: US20090130230A1  Published: 21/May/2009

Title: SILICATE CONTAINING COMPOSITIONS AND METHODS OF TREATMENT

Applicant/Assignee: 7 OAKS PHARMACEUTICAL CORPORATION

Application No.: 12/250624   Filing Date: 14/Oct/2008

Abstract:The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. The compositions of the present invention can also be useful in treating spinal cord injury, tissue remodeling, and promoting bone growth and repair.

Priority: US20070960794P Applic. Date: 2007-10-15; US20080071754P Applic. Date: 2008-05-15; US20080090833P Applic. Date: 2008-08-21

Inventor: STANLEY SR RICHARD THOMAS [US]; STANLEY DAVID EDWARD [US]


Application No.: US20090130695A1  Published: 21/May/2009

Title: GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof

Applicant/Assignee: SUGEN, INC

Application No.: 12/232134   Filing Date: 11/Sep/2008

Abstract:The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.

Priority: US2003-611671 Applic. Date: 2003-07-02; US20020393600P Applic. Date: 2002-07-05; US20030460053P Applic. Date: 2003-04-04

Inventor: SMEAL TOD R [US]; CALLOW MARINELLA G [US]; JALLAL BAHIJA [US]; ZOZULYA SERGEY [US]; GISHIZKY MIKHAIL L [US]


Application No.: US20090131404A1  Published: 21/May/2009

Title: Combinations

Applicant/Assignee:

Application No.: 12/290106   Filing Date: 27/Oct/2008

Abstract:The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof and (b) at least one of the active ingredients selected from the group consisting of (i) HMG-Co-A reductase inhibitors or a pharmaceutically acceptable salt thereof

and (ii) ACE inhibitors or a pharmaceutically acceptable salt thereof

and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

Priority: US2003-362341 Applic. Date: 2003-06-18; WO2001EP09586 Applic. Date: 2001-08-20; US2000-643642 Applic. Date: 2000-08-22

Inventor: ALLISON MALCOLM [CH]; GATLIN MARJORIE REGAN [US]


Application No.: US20090131424A1  Published: 21/May/2009

Title: THIAZOLYL-DIHYDRO-CHINAZOLINE

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 12/351017   Filing Date: 09/Jan/2009

Abstract:Disclosed are compounds of general formula (I), wherein the groups A, R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.

Priority: EP20060112296 Applic. Date: 2006-04-06; US2007-690355 Applic. Date: 2007-03-23

Inventor: BRANDL TRIXI [CH]; MAIER UDO [DE]; HOENKE CHRISTOPH [DE]; JOERGENSEN ANNE T [DK]; PAUTSCH ALEXANDER [DE]; BREITFELDER STEFFEN [DE]; GRAUERT MATTHIAS [DE]; HOFFMANN MATTHIAS [DE]; SCHEUERER STEFAN [DE]; ERB KLAUS [DE]; PIEPER MICHAEL [DE]; PRAGST INGO [DE]


Application No.: US20090131541A1  Published: 21/May/2009

Title: Gelatin-containing topical composition

Applicant/Assignee: AQUA BIO TECHNOLOGY ASA

Application No.: 11/914722   Filing Date: 19/May/2006

Abstract:This invention provides a topical pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically active agent and a gelling agent, characterized in that said gelling agent comprises a fish gelatin and a polysaccharide.

Priority: GB20050010286 Applic. Date: 2005-05-19; GB20060007174 Applic. Date: 2006-04-10; WO2006GB01874 Applic. Date: 2006-05-19

Inventor: DRAGET KURT INGAR [NO]; HAUG INGVILD JOHANNE [NO]; SMIDSROD OLAV AASMUND [NO]


Application No.: US20090131717A1  Published: 21/May/2009

Title: COMPOSITION FOR PROTECTING SKIN

Applicant/Assignee:

Application No.: 12/354982   Filing Date: 16/Jan/2009

Abstract:Disclosed are a composition for protecting skin and uses thereof. The composition comprises sphingomyelin as an active ingredient and protects the skin by inhibiting skin aging, treating a skin wound and improving a skin barrier.

Priority: KR20030068932 Applic. Date: 2003-10-02; KR20040075864 Applic. Date: 2004-09-22; US2007-574275 Applic. Date: 2007-04-20; WO2004KR02517 Applic. Date: 2004-10-01

Inventor: PARK CHANGSEO [KR]; KIM SUNKI [KR]; KIM JINWOOK [KR]; KANG HYEONGJOON [KR]; HAN BOKYUNG [KR]; LEE YOUNGGON [KR]; CHUNG SOYOUNG [KR]; CHOI WANGKEUN [KR]; NAM SANG JUNE [KR]


Application No.: US20090136431A1  Published: 28/May/2009

Title: Stilbene Like Compounds as Novel HDAC Inhibitors

Applicant/Assignee: ORCHID RESEARCH LABORATORIES LIMITED

Application No.: 12/084430   Filing Date: 06/Nov/2006

Abstract:The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.

Priority: IN2005CH01644 Applic. Date: 2005-11-10; WO2006IB03114 Applic. Date: 2006-11-06

Inventor: SRINIVAS AKELLA S S V [IN]; BALAN URKALAN K [IN]; PUNTHALIR NARAYANA S [IN]; VELMURUGAN RAMA S [IN]; RAJAGOPAL SRIRAM [IN]; REDDY GADDAM O [IN]; KACHHADIA VIRENDRA [IN]


Application No.: US20090136433A1  Published: 28/May/2009

Title: Use of Hydrophobin-Polypeptides and Conjugates From Hydrophobin-Polypeptides Having Active and Effect Agents and the Production Thereof and Use Thereof In the Cosmetic Industry

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/922650   Filing Date: 23/Jun/2006

Abstract:Cosmetic composition for the treatment of keratin-containing materials, mucosa and teeth, comprising at least one hydrophobin polypeptide sequence (i) (I) Xn-C1-X1-50-C2-X0-5-C3-Xp-C4-X1-100-C5-X1-50-C6- X0-5-C7-X1-50-C8-Xm

Priority: DE200510029704 Applic. Date: 2005-06-24; WO2006EP63485 Applic. Date: 2006-06-23

Inventor: SUBKOWSKI THOMAS [DE]; KAROS MARVIN [DE]; LEMAIRE HANS-GEORG [DE]; BARG HEIKO [DE]; BOLLSCHWEILER CLAUS [DE]


Application No.: US20090136554A1  Published: 28/May/2009

Title: Transdermal sustained release drug delivery

Applicant/Assignee: ALZA CORPORATION

Application No.: 12/288753   Filing Date: 23/Oct/2008

Abstract:Provided herein are microprojections and microprojection arrays for delivering biologically active agents. Also provided herein are compositions suitable for coating such microprojections and microprojection arrays.

Priority: US20070982119P Applic. Date: 2007-10-23

Inventor: AMERI MAHMOUD [US]; MAA YUH-FUN [US]


Application No.: US20090136604A1  Published: 28/May/2009

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR TREATING SENSITIVE SKIN, MUCOUS MEMBRANES AND SCALPS

Applicant/Assignee: L'OREAL

Application No.: 12/175129   Filing Date: 17/Jul/2008

Abstract:Sensitive skin, mucous membranes and scalps are treated by administering to individuals in need of such treatment, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: FR20070056551 Applic. Date: 2007-07-17; US20070930000P Applic. Date: 2007-07-20

Inventor: BRETON LIONEL [FR]; MAHE YANN [FR]; MARTIN RICHARD [FR]


Application No.: US20090137438A1  Published: 28/May/2009

Title: Hydrocolloids and Process Therefor

Applicant/Assignee:

Application No.: 12/350590   Filing Date: 08/Jan/2009

Abstract:The present invention relates to a shampoo composition comprising a minced polygalactomannan hydrocolloid(s) in combination with a water soluble silicone compound.

Priority: US2004-014424 Applic. Date: 2004-12-16

Inventor: LEPILLEUR CAROLE A [US]; FRUSCELLA JEFFREY A [US]


Application No.: US20090137475A1  Published: 28/May/2009

Title: MEDICAMENTS AND PROTEINS BASED ON TGF-BETA MONOMERS FOR THE TREATMENT OF WOUNDS

Applicant/Assignee:

Application No.: 12/282472   Filing Date: 12/Mar/2007

Abstract:There is provided the use of monomeric TGF-betas, or there fragments or derivatives, as medicaments. These medicaments preferably comprise monomeric TGF-beta3, or fragments or derivatives thereof. The medicaments provided may be used in the acceleration of wounding and/or the inhibition of scarring, in the promotion of epithelial regeneration, or in the prevention and/or treatment of fibrotic disorders.

Priority: WO2007GB00834 Applic. Date: 2007-03-12; GB20060004966 Applic. Date: 2006-03-11

Inventor: FERGUSON MARK WILLIAM JAMES [GB]; MELLOR PHILLIP [GB]; LAVERTY HUGH GERARD [GB]; OCCLESTON NICK [GB]; O'KANE SHARON [GB]; ATKINSON EMMA [GB]


Application No.: US20090137523A1  Published: 28/May/2009

Title: Compositions for External Application, Containing Adenosyl Cobalamin for Improvement of Skin Diseases

Applicant/Assignee:

Application No.: 11/996574   Filing Date: 18/Oct/2006

Abstract:The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). Said composition contains adenosyl cobalamin (coenzyme B12), opt. in admixture with other cobalamins. Preferable said composition is present in the form of liposomal preparations, which are made of a phospholipid and cholesterol.

Priority: KR20050120648 Applic. Date: 2005-12-09; WO2006KR04233 Applic. Date: 2006-10-18

Inventor: SHIN BYUNG CHEOL [KR]; SEONG HASOO [KR]; LEE AERI [KR]; KONG JAE YANG [KR]; CHEON HYAE GYEONG [KR]; CHO YOUNG SIK [KR]; JUN SUNG SOO [KR]; JO YOUNG GWAN [KR]


Application No.: US20090137534A1  Published: 28/May/2009

Title: Skin treatment compositions and methods

Applicant/Assignee:

Application No.: 11/986719   Filing Date: 26/Nov/2007

Abstract:A skin treatment composition or cosmetic product comprising a) two or more active components, namely, at least one dermatological acid and at least one meroterpene and b) a dermatologically acceptable carrier.

Priority:

Inventor: CHAUDHURI RATAN K [US]


Application No.: US20090137540A1  Published: 28/May/2009

Title: COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL INFLAMMATION

Applicant/Assignee: MERITAGE PHARMA, INC

Application No.: 12/269650   Filing Date: 12/Nov/2008

Abstract:Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US20080035348P Applic. Date: 2008-03-10; US20080054103P Applic. Date: 2008-05-16; US20080054105P Applic. Date: 2008-05-16; US20070012012P Applic. Date: 2007-12-06; US20080054107P Applic. Date: 2008-05-16; US20070015998P Applic. Date: 2007-12-21; US20080019818P Applic. Date: 2008-01-08; US20080034941P Applic. Date: 2008-03-07; US20080054106P Applic. Date: 2008-05-16; US20080090658P Applic. Date: 2008-08-21; US20070987720P Applic. Date: 2007-11-13; US20080054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE [US]; HILL MALCOLM [US]


Application No.: US20090137556A1  Published: 28/May/2009

Title: COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING ACE INHIBITORS AND/OR ANGIOTENSIN II RECEPTOR ANTAGONISTS

Applicant/Assignee: ACE APS

Application No.: 11/573781   Filing Date: 18/Aug/2005

Abstract:In one aspect, the present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist for the preparation of a medicament for the treatment of a dermatological disorder, particularly by topical application of said ACE inhibitor and/or angiotensin II receptor antagonist. The present invention also provides cosmetic methods for improving and/or maintaining the skin tone of an individual suffering from, or at risk of suffering from, a dermatological disorder, said method comprising contacting the skin of said individual with an ACE inhibitor and/or angiotensin II receptor antagonist.

Priority: DK20040001247 Applic. Date: 2004-08-18; US20040607919P Applic. Date: 2004-09-08; WO2005DK00530 Applic. Date: 2005-08-18

Inventor: BONNICHSEN RICHARD [SC]


Application No.: US20090137591A1  Published: 28/May/2009

Title: COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

Applicant/Assignee: IRM LLC

Application No.: 11/815096   Filing Date: 03/Feb/2006

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARdelta.

Priority: US20050649962P Applic. Date: 2005-02-03; WO2006US03924 Applic. Date: 2006-02-03

Inventor: COW CHRISTOPHER [US]; EPPLE ROBERT [US]; WANG XING [US]; XIE YONGPING [US]; SEIDEL HANS MARTIN [US]


Application No.: US20090137610A1  Published: 28/May/2009

Title: SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS

Applicant/Assignee: IRM LLC

Application No.: 12/160302   Filing Date: 25/Jan/2007

Abstract:The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US20060763557P Applic. Date: 2006-01-30; WO2007US02315 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT [US]; RUSSO ROSS [US]; AZIMIOARA MIHAI [US]; COW CHRISTOPHER [US]; MOLTENI VALENTINA [US]; LI XIAOLIN [US]; CHIANELLI DONATELLA [US]


Application No.: US20090137628A1  Published: 28/May/2009

Title: Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain

Applicant/Assignee: BRIDGE PHARMA, INC

Application No.: 11/991771   Filing Date: 22/Sep/2006

Abstract:Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided. Also provided are solutions of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine for injection, characterized by short onset time and long duration of activity. Formulations containing both 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine and capsaicin are also provided.

Priority: US20050719904P Applic. Date: 2005-09-23; US20060839783P Applic. Date: 2006-08-24; WO2006US37070 Applic. Date: 2006-09-22

Inventor: ABERG A K GUNNAR [US]; JOHNSON KEITH [US]


Application No.: US20090137909A1  Published: 28/May/2009

Title: METHOD FOR IMAGING AND TREATING ORGANS AND TISSUES

Applicant/Assignee: ONCOFLUOR, INC

Application No.: 12/212582   Filing Date: 17/Sep/2008

Abstract:The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.

Priority: US20070973630P Applic. Date: 2007-09-19

Inventor: LUIKEN GEORGE A [US]


Application No.: US20090142285A1  Published: 04/Jun/2009

Title: COSMETIC COMPOSITION COMPRISING ASCORBIC ACID 2-GLUCOSIDE AND ERGOTHIONEINE

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/275151   Filing Date: 20/Nov/2008

Abstract:This invention relates to a cosmetic composition allowing the effects of skin aging to be reduced or delayed, comprising as the cosmetically active ingredients ascorbic acid 2-glucoside and ergothioneine. The invention also relates to the use of these cosmetically active ingredients in a cosmetic composition as agents to stimulate DNA repair enzymes, particularly enzymes to repair oxidised DNA bases in dermal and epidermal cells. Finally, the invention relates to a cosmetic treatment process involving this use.

Priority: FR20070059469 Applic. Date: 2007-11-30

Inventor: KURFURST ROBIN [FR]; BONNET-DUQUENNOY MATHILDE [FR]


Application No.: US20090142297A1  Published: 04/Jun/2009

Title: 5-SUBSTITUTED ISOINDOLINE COMPOUNDS

Applicant/Assignee:

Application No.: 12/130445   Filing Date: 30/May/2008

Abstract:This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US2007-897339 Applic. Date: 2007-08-31; US20070925513P Applic. Date: 2007-04-20; US20070937782P Applic. Date: 2007-06-28

Inventor: MULLER GEORGE W [US]; CHEN ROGER SHEN-CHU [US]; RUCHELMAN ALEXANDER L [US]


Application No.: US20090142348A1  Published: 04/Jun/2009

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC LEXICON PHARMACEUTICALS, INC

Application No.: 11/814606   Filing Date: 21/May/2007

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20060820717P Applic. Date: 2006-07-28; WO2007US69347 Applic. Date: 2007-05-21

Inventor: DE SAUVAGE FREDERIC [US]; FILVAROFF ELLEN [US]; JUNUTULA JAGATH REDDY [US]; PAYNE BOBBY JOE [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; VOGEL PETER [US]


Application No.: US20090142372A1  Published: 04/Jun/2009

Title: Therapeutic composition for use in the prevention and treatment of bone metastases

Applicant/Assignee:

Application No.: 11/921421   Filing Date: 31/May/2006

Abstract:The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.

Priority: WO2006EP05191 Applic. Date: 2006-05-31; DE200510024836 Applic. Date: 2005-05-31; DE200610004612 Applic. Date: 2006-02-01

Inventor: JOCHEM RALF [DE]; ARMBRUSTER FRANZ PAUL [DE]; BRAUN VEIT [DE]; VON EICHEL-STREIBER CHRISTOPH [DE]


Application No.: US20090142420A1  Published: 04/Jun/2009

Title: Cosmetic Composition with Anti-Free Radical Activity

Applicant/Assignee: LVMH RECHERCHE

Application No.: 11/883779   Filing Date: 11/Jun/2007

Abstract:A cosmetic composition has an association of at least three of the following substances with anti-free radical activity, selected from: A cosmetic composition has an association of at least three of the following substances with anti-free radical activity, selected from: 1) ebselen

or idebenone

or an association of the two

and 2) at least one substance with anti-free radical activity, or at least two substances with anti-free radical activity for obtaining said association of at least three substances with anti-free radical activity, said substance(s) being selected from: a) a substance of chemical formula (I) below: in which: R=a linear or branched, saturated or unsaturated C1-C16 hydrocarbon chain

and R1, R2 and R3 are identical or different and are a hydrogen atom or a methyl or methoxy radical, and its esters

b) an extract of Edelweiss

c) an extract of Emblica

and d) N-acetylcysteine. The anti-free radical activity is greatly improved.

Priority: FR20060052099 Applic. Date: 2006-06-12; WO2007FR51405 Applic. Date: 2007-06-11

Inventor: ANDRE PATRICE [FR]; RENIMEL ISABELLE [FR]; GODENIR CELINE [FR]; HOCQUAUX MICHEL [FR]


Application No.: US20090142427A1  Published: 04/Jun/2009

Title: Composition and its Therapeutic Use

Applicant/Assignee: VERITRON LIMITED

Application No.: 12/367099   Filing Date: 06/Feb/2009

Abstract:A composition having a variety of therapeutic and cosmetic uses comprises: (i) a vitamin

(ii) a metal salt that provides metal ions in vivo

and (iii) insulin or a growth hormone. Such a composition is useful for treating, for example, genetic disorders, skin diseases, cancer and viral infections.

Priority: GB20020012405 Applic. Date: 2002-05-29; US2006-534914 Applic. Date: 2006-09-25; US2003-447770 Applic. Date: 2003-05-29; US20020407373P Applic. Date: 2002-08-30

Inventor: HAMID AL-SARI MISHAL [US]; YOUNIS RAFEDA M A [AE]; AL SARI KARAM M H [AE]; AL SARI SAAD M H [AE]; AL SARI AHMAD M H [AE]


Application No.: US20090143458A1  Published: 04/Jun/2009

Title: USE OF ACE INHIBITORS AND/OR ANGIOSTENSIN II RECEPTOR ANTAGONISTS FOR THE IMPROVING AND/OR MAINTAINING THE SKIN TONE AND FOR THE TREATMENT OF SKIN AGEING

Applicant/Assignee: ACE APS

Application No.: 10/597545   Filing Date: 28/Jan/2005

Abstract:The present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist of the preparation of a medicament for the treatment of skin ageing or wrinkling. Furthermore, the present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist for the preparation of a cosmetic composition.

Priority: DK20040000136 Applic. Date: 2004-01-30; US20040553661P Applic. Date: 2004-03-16; WO2005DK00065 Applic. Date: 2005-01-28

Inventor: JENSEN BENNY V [DK]; BONNICHSEN RICHARD [SC]


Application No.: US20090143469A1  Published: 04/Jun/2009

Title: SALTS OF NATEGLINIDE

Applicant/Assignee:

Application No.: 12/366936   Filing Date: 06/Feb/2009

Abstract:The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular disease, or conditions associated therewith.

Priority: US2004-507255 Applic. Date: 2004-09-28; WO2003EP02447 Applic. Date: 2003-03-10; US20020363178P Applic. Date: 2002-03-11

Inventor: SUTTON PAUL ALLEN [US]; VIVILECCHIA RICHARD V [US]; PARKER DAVID JOHN [US]; DE LA CRUZ MARILYN [US]


Application No.: US20090143714A1  Published: 04/Jun/2009

Title: Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives

Applicant/Assignee:

Application No.: 12/271100   Filing Date: 14/Nov/2008

Abstract:Personal care compositions containing an active selected from the group consisting of Boswellia serratta tree resins and gums, xymenynic acid, glycyrrhizinic acid in extract form, their salts, their derivatives, their precursors, and/or combinations thereof are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US20070990940P Applic. Date: 2007-11-29

Inventor: MILLIKIN CHERI LYNN [US]; BISSETT DONALD LYNN [US]; GOODMAN LAURA JACKSON [US]


Application No.: US20090143762A1  Published: 04/Jun/2009

Title: Methods and Compositions for Enhancing the Viability Of Microneedle Pores

Applicant/Assignee: ALLTRANZ INC

Application No.: 12/325919   Filing Date: 01/Dec/2008

Abstract:Described herein is a method of transdermally administering one or more pharmaceutically active agents to a mammal. The method comprises administering one or more active pharmaceutical agents to the skin of the subject, in conjunction with microneedles and one or more COX inhibitors, whereby the COX inhibitors facilitate the absorption of the active pharmaceutical agents by prolonging the pore opening created by the application of the microneedle.

Priority: US20070990972P Applic. Date: 2007-11-29

Inventor: STINCHCOMB AUDRA LYNN [US]; BANKS STAN LEE [US]


Application No.: US20090148391A1  Published: 11/Jun/2009

Title: SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS

Applicant/Assignee: SYMRISE GMBH & CO. KG

Application No.: 12/159951   Filing Date: 05/Jan/2007

Abstract:The present invention relates to specific synergistic active skin- and/or hair-lightening and/or senile keratosis-reducing (cosmetic or pharmaceutical) preparations comprising a mixture comprising or consisting of a) a tyrosinase-inhibiting amount of one or more compounds of the formula 1: wherein: R1 is hydrogen, methyl, straight-chain or branched alkyl having 2-4 C atoms, OH or halogen, R2 is hydrogen, methyl or straight-chain or branched alkyl having 2-5 C atoms, R3 is methyl or straight-chain or branched alkyl having 2-5 C atoms, and R4 and R5 are, independently of one another hydrogen, methyl, straight-chain or branched alkyl having 2-5 C atoms, OH or halogen and b) a skin- and/or hair lightening and/or senile keratosis-reducing amount of one or more compounds selected from the group consisting of (i) chelating agents, (ii) phenolic derivatives, plant extracts with an amount of phenolic derivatives and (iii) organic acid derivatives as well as uses thereof.

Priority: US20060756205P Applic. Date: 2006-01-05; US20060804319P Applic. Date: 2006-06-09; WO2007EP50124 Applic. Date: 2007-01-05

Inventor: SCHMAUS GERHARD [DE]; LANGE SABINE [DE]; VIELHABER GABRIELE [DE]; SCHAPER KARIN [DE]; PILLAI RAVIKUMAR [US]


Application No.: US20090148395A1  Published: 11/Jun/2009

Title: BIOMEDICAL FOAM ARTICLES

Applicant/Assignee: BAYER INNOVATION GMBH

Application No.: 12/244236   Filing Date: 02/Oct/2008

Abstract:The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.

Priority: DE200710048080 Applic. Date: 2007-10-05

Inventor: FUGMANN BURKHARD [DE]; DIETZE MELITA [DE]; MAGER MICHAEL [DE]; RISCHE THORSTEN [DE]; HECKES MICHAEL [DE]; RUDHARDT DANIEL [DE]; GERTZMANN ROLF [DE]; SCHONBERGER JAN [DE]; DORR SEBASTIAN [DE]


Application No.: US20090148501A1  Published: 11/Jun/2009

Title: PROCESS FOR THE PREPARATION OF AROMATIZED CHEWING FOAMS FOR COSMETIC PRODUCTS

Applicant/Assignee: BAYER MATERIALSCIENCE AG

Application No.: 12/253559   Filing Date: 17/Oct/2008

Abstract:The invention relates to a process for the preparation of novel aromatized chewing foams for the oral care sector based on polyurethane-polyureas and aromatizing compositions

Priority: US20070999611P Applic. Date: 2007-10-19

Inventor: HOFACKER STEFFEN [DE]; NIESTEN MEIKE [DE]; RISCHE THORSTEN [DE]; DORR SEBASTIAN [DE]; KRAMER THORSTEN [DE]; SCHWANNECKE DIRK [US]; ROHE GABRIELE [DE]; HEPPERLE JENS [DE]; KEMPKES HARTWIG [DE]; LETMATHE CLAUDIA [DE]


Application No.: US20090148513A1  Published: 11/Jun/2009

Title: Compositions and methods for crystallizing antibodies

Applicant/Assignee:

Application No.: 12/228038   Filing Date: 08/Aug/2008

Abstract:The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale

a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.

Priority: US20070963964P Applic. Date: 2007-08-08

Inventor: FRAUNHOFER WOLFGANG [US]; BORHANI DAVID W [US]; WINTER GERHARD [DE]; GOTTSCHALK STEFAN [DE]


Application No.: US20090148544A1  Published: 11/Jun/2009

Title: Cosmetic composition containing an extract from lotus and method of cosmetic care using said composition

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/316144   Filing Date: 10/Dec/2008

Abstract:The invention relates to a cosmetic composition containing at least one extract from at least one part of the Sacred Lotus plant (Nelumbo nucifera) in a cosmetically acceptable vehicle compatible with topical application on the skin, wherein said composition contains an aqueous extract of Sacred Lotus root and it additionally contains at least one active agent selected from the group comprising active agents with energizing or revitalizing activity, preferably diguanosine polyphosphate or an extract containing it, in particular an extract from Artemia salina

active agents stimulating the secretion of beta-endorphins, preferably an N-acetyl-Tyr-Arg-hexadecyl ester dipeptide

anti-radical agents such as tocopherol, in particular alpha-tocopherol in the form of a salt or a base, or one of its esters, for example tocopherol acetate, and plant extracts containing them as well as flavonoids and anthocyanins and plant extracts containing them, in particular extracts of Sacred Lotus flower and anti-inflammatory agents, in particular those having a phospholipase A2 inhibitory action, such as the ascorbyl tocopheryl phosphates, in particular potassium ascorbyl tocopheryl phosphate. It also relates to a method of cosmetic care quite particularly intended for the care of sensitive or reactive skin.

Priority: FR20070008590 Applic. Date: 2007-12-10; FR20080058318 Applic. Date: 2008-12-05

Inventor: ARCHAMBAULT JEAN-CHRISTOPHE [FR]; FRANCHI JOCELYNE [FR]; KORICHI RODOLPHE [FR]


Application No.: US20090149531A1  Published: 11/Jun/2009

Title: CHEMICAL COMPOSITION DERIVED FROM P-HYDROXYPHENYL PROPIONIC ACID FOR THE TREATMENT OF PSORIASIS

Applicant/Assignee: APOTEKNOS PARA LA PIEL, S.L

Application No.: 12/332324   Filing Date: 10/Dec/2008

Abstract:The present invention is a chemical composition including: Use of the compound with the chemical formula can be applied in pharmaceutical compositions for the treatment of psoriasis.

Priority: EP20070380346 Applic. Date: 2007-12-11

Inventor: PIVEL RANIERI JUAN PABLO [ES]; FERRER CUESTA JUAN MANUEL [ES]; MARTINEZ GALAN FERNANDO [ES]; IRACHE JUAN MANUEL [ES]; NOVELLA ROBISCO JOSE LUIS [ES]; PEREZ RUEDA JUAN JOSE [ES]; MARIA MARTIN MA PAZ [ES]; ALVAREZ-BUILLA GOMEZ JULIO [ES]; BERMEJO JAIME [ES]; VIDAL VANACLOCHA FERNANDO [ES]


Application No.: US20090149550A1  Published: 11/Jun/2009

Title: WRINKLE REDUCTION AGENT, LIPOLYSIS ACCELERATOR, COMPOSITION FOR EXTERNAL USE ON SKIN, AND FOOD OR BEVERAGE COMPOSITION

Applicant/Assignee: KAO CORPORATION

Application No.: 12/335326   Filing Date: 15/Dec/2008

Abstract:An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms) or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.

Priority: JP20040250178 Applic. Date: 2004-08-30; JP20050004506 Applic. Date: 2005-01-11; JP20040321698 Applic. Date: 2004-11-05; WO2005JP15635 Applic. Date: 2005-08-29; US2007-661401 Applic. Date: 2007-02-28; JP20050176165 Applic. Date: 2005-06-16; JP20050144765 Applic. Date: 2005-05-17

Inventor: SUGITA JUN [JP]; IKEMOTO TAKESHI [JP]; AKAZAWA YUMIKO [JP]; KOBAYASHI YURIE [JP]; MITANI MITSUMASA [JP]; HARATAKE AKINORI [US]; KOMIYA AYA [JP]


Application No.: US20090155194A1  Published: 18/Jun/2009

Title: ENHANCED PHOTOSTABILITY OF AVOBENZONE IN THE PRESENCE OF ZINC OXIDE USING PHOSPHATE-BASED EMULSIFIERS

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 11/958907   Filing Date: 18/Dec/2007

Abstract:The photostability of avobenzone in a sunscreen composition in the presence of zinc oxide is stabilized against photodegradation using phosphate-based emulsifiers.

Priority:

Inventor: MEYER THOMAS A [US]; BEASLEY DONATHAN G [US]


Application No.: US20090155235A1  Published: 18/Jun/2009

Title: AGGREGATES WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN

Applicant/Assignee: IDEA AG

Application No.: 12/356381   Filing Date: 20/Jan/2009

Abstract:The invention describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug

the third component alternatively, can take the role of a drug. The patent further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The patent finally reveals suitable methods and favourable conditions for carrier manufacturing and application.

Priority: US2003-357618 Applic. Date: 2003-02-04; US20020417847P Applic. Date: 2002-10-11

Inventor: CEVC GREGOR [DE]; VIERL ULRICH [DE]


Application No.: US20090155292A1  Published: 18/Jun/2009

Title: COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS

Applicant/Assignee:

Application No.: 12/044435   Filing Date: 07/Mar/2008

Abstract:The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.

Priority: US20070893530P Applic. Date: 2007-03-07

Inventor: SANTAMARIA PEDRO [CA]; MOORE ANNA [US]


Application No.: US20090155307A1  Published: 18/Jun/2009

Title: IMMUNOSTIMULATORY NUCLEIC ACID OIL-IN-WATER FORMULATIONS AND RELATED METHODS OF USE

Applicant/Assignee: COLEY PHARMACEUTICAL GROUP, LTD

Application No.: 12/196201   Filing Date: 21/Aug/2008

Abstract:The invention involves methods and compositions of an immunostimulatory nucleic acid in oil-in-water emulsions for topical delivery. The compositions can be used to stimulate immune responses, particularly useful in the prevention and/or treatment of infectious disease and cancer.

Priority: US2004-816220 Applic. Date: 2004-04-01; US20030459920P Applic. Date: 2003-04-02; US20030461903P Applic. Date: 2003-04-10

Inventor: DAVIS HEATHER L [CA]; MCCLUSKIE MICHAEL J [CA]


Application No.: US20090155317A1  Published: 18/Jun/2009

Title: COSMETIC OR DEMOPHARMACEUTICAL COMPOSITION COMPRISING ENKEPHALIN-DERIVED PEPTIDES TO REDUCE AND/OR ELIMINATE FACIAL WRINKLES

Applicant/Assignee: LIPOTEC, S.A

Application No.: 11/910719   Filing Date: 29/Mar/2006

Abstract:The invention relates to a cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles. Said cosmetic or dermopharmaceutical composition for application in the skin, preferably in the skin of the face, to reduce and/or eliminate facial wrinkles, preferably facial expression wrinkles and comprises a cosmetically or dermopharmaceutically effective amount of a peptide of general formula (I). The invention also relates to the use of the peptide of general formula (I) in the preparation of a cosmetic or dermopharmaceutical composition reducing and/or eliminating facial wrinkles.

Priority: ES20050000824 Applic. Date: 2005-04-08; WO2006ES00151 Applic. Date: 2006-03-29

Inventor: FERRER MONTIEL ANTONIO [ES]; CEBRIAN PUCHE JUAN [ES]; PUIG MONTIEL ARTURO [ES]


Application No.: US20090155341A1  Published: 18/Jun/2009

Title: Medical device and a method for applying a biochemically active material on one or more body parts

Applicant/Assignee: OHK MEDICAL DEVICES LTD

Application No.: 12/314501   Filing Date: 11/Dec/2008

Abstract:A medical device having a sleeve-shaped elastic body which is rolled up to form an annular structure and may be rolled down to annularly contacting one or more body parts, such as limbs, a biochemically active material, such as a disinfecting material, added substantially to a portion of the sleeve-shaped elastic body, and a pressure-exerting element for rolling down the sleeve-shaped elastic body while applying an external pressure on a contact point between the portion and the one or more body parts.

Priority: US20070006033P Applic. Date: 2007-12-14

Inventor: GAVRIELY NOAM [IL]; GAVRIELY OREN [IL]; KABAK OMER [IL]


Application No.: US20090155347A1  Published: 18/Jun/2009

Title: Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane

Applicant/Assignee: DSM IP ASSETS B.V

Application No.: 12/226191   Filing Date: 28/Apr/2006

Abstract:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is -O-, -NH- or -NR2- and R2H or C1-C20-alkyl

and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid

use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane

and also both those compounds of the formula (I) in which X is -NR2- and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid, as such.

Priority: WO2006EP03998 Applic. Date: 2006-04-28

Inventor: ZIEGLER HUGO [CH]; IMFELD DOMINIK [CH]; STOCKLI MARTIN [CH]; HEIDL MARC [DE]


Application No.: US20090155366A1  Published: 18/Jun/2009

Title: OSTEOINDUCTIVE MATERIALS

Applicant/Assignee: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH

Application No.: 12/336895   Filing Date: 17/Dec/2008

Abstract:The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic roteins, wherein depending on the subject matter the proteins may be dimeric or monomeric proteins. The osteoinductive materials according to the present invention have improved properties. The invention further concerns methods for producing the respective improved osteoinductive materials.

Priority: EP20030007141 Applic. Date: 2003-03-28; US2005-550958 Applic. Date: 2005-09-28; WO2004EP03238 Applic. Date: 2004-03-26

Inventor: POHL JENS [DE]; BECHTOLD ROLF [DE]; KRUSE MICHAEL [DE]


Application No.: US20090155383A1  Published: 18/Jun/2009

Title: Personal Care Compositions Comprising Undecyl Sulfates

Applicant/Assignee:

Application No.: 12/255920   Filing Date: 22/Oct/2008

Abstract:A personal care composition utilizing undecyl sulfates and/or ethoxylated undecyl sulfates (undeceth sulfates).

Priority: US20070000466P Applic. Date: 2007-10-26; US20080105982P Applic. Date: 2008-10-16

Inventor: KITKO DAVID JOHNATHAN [US]; HUTTON III HOWARD DAVID [US]; JOHNSON ERIC SCOTT [US]; HUTCHINS THOMAS ALLEN [US]


Application No.: US20090156486A1  Published: 18/Jun/2009

Title: PRODUCTION OF HUMAN DEFENSINS IN PLANT CELLS

Applicant/Assignee:

Application No.: 12/096860   Filing Date: 14/Dec/2006

Abstract:The present invention relates, generally, to the production of human defensins from plant cells. Heterologous DNA comprising genes encoding one or more desired human defensins are introduced into plant cells. The one or more human defensins can be recombinantly-produced in the plant cells, purified from the plant cells, and used as an anti-infective agent, a wound treatment agent, a skin care agent, or an agent in the treatment of various intestinal diseases, including irritable bowel disease (IBD), ulcerative colitis, and Crohn's disease. The recombinantly-produced alpha-defensins can be provided as oral and topical formulations.

Priority: US20050750375P Applic. Date: 2005-12-15; WO2006US47606 Applic. Date: 2006-12-14

Inventor: HUANG NING [US]; ZHANG DESHUI [US]


Application No.: US20090156507A1  Published: 18/Jun/2009

Title: Cell permeable conjugates of peptides for inhibition of protein kinases

Applicant/Assignee: CUREGENICS LTD

Application No.: 12/229398   Filing Date: 22/Aug/2008

Abstract:The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. The first moiety is joined to the second moiety through a linker or a spacer. The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed.

Priority: IL20030156429 Applic. Date: 2003-06-12; US2005-295793 Applic. Date: 2005-12-06; WO2004IL00505 Applic. Date: 2004-06-13

Inventor: LIVNAH NARIT [IL]; LEVITZKI ALEXANDER [IL]; SENDEROVITZ HANOCH [IL]; YECHEZKEL TAMAR [IL]; SALITRA YOSEF [IL]; LITMAN PNINIT [IL]; OHNE OSNAT [IL]


Application No.: US20090156545A1  Published: 18/Jun/2009

Title: Substituted Phosphate Esters of Nucleoside Phosphonates

Applicant/Assignee:

Application No.: 11/887501   Filing Date: 30/Mar/2006

Abstract:Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleoside of interest to alkyloxyalkyl-phosphate or alkyl-phosphate in a phosphate-phosphono anhydride linkage to provide a modified nucleoside phosphonate drug.

Priority: US20050667739P Applic. Date: 2005-04-01; WO2006US12121 Applic. Date: 2006-03-30

Inventor: HOSTETLER KARL Y [US]; BEADLE JAMES R [US]; RUIZ JACQUELINE C [US]


Application No.: US20090156557A1  Published: 18/Jun/2009

Title: KINASE INHIBITORS

Applicant/Assignee: TAKEDA SAN DIEGO, INC

Application No.: 12/103625   Filing Date: 15/Apr/2008

Abstract:Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20070912625P Applic. Date: 2007-04-18

Inventor: BROWN JASON W [US]; DONG QING [US]; PARASELLI BHEEMA R [US]; STAFFORD JEFFREY A [US]; GONG XIANCHANG [US]; LIU YAN [US]; SCORAH NICHOLAS [US]; WALLACE MICHAEL B [US]


Application No.: US20090156563A1  Published: 18/Jun/2009

Title: Glucan Compositions

Applicant/Assignee:

Application No.: 12/085271   Filing Date: 20/Nov/2006

Abstract:A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1x106 to 12x106

b) a cosmetically or pharmaceutically acceptable carrier

and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1, compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.

Priority: EP20050111504 Applic. Date: 2005-11-30; EP20060116766 Applic. Date: 2006-07-07; WO2006EP68645 Applic. Date: 2006-11-20

Inventor: BASCHONG WERNER [CH]; MONGIAT SEBASTIEN [FR]; OCHS DIETMAR [DE]


Application No.: US20090156613A1  Published: 18/Jun/2009

Title: Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor

Applicant/Assignee:

Application No.: 12/316835   Filing Date: 16/Dec/2008

Abstract:Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Priority: US20070014572P Applic. Date: 2007-12-18

Inventor: KINDRACHUK DAVID E [US]; VENABLE JENNIFER D [US]


Application No.: US20090156649A1  Published: 18/Jun/2009

Title: Cellular phosphorylation potential enhancing compositions preparation and use thereof

Applicant/Assignee:

Application No.: 12/222237   Filing Date: 04/Aug/2008

Abstract:A pharmaceutical composition comprising as an active phosphorylation potential enhancing substance a pharmaceutically-acceptable salt of an alpha-keto carboxylic acid thereof alone or in combination with nicatinamide and creatine and, its use and products containing the same.

Priority: US2008-082697 Applic. Date: 2008-04-11; US2003-643080 Applic. Date: 2003-08-19; US2001-828589 Applic. Date: 2001-04-09; US2000-550047 Applic. Date: 2000-04-14; US1997-999767 Applic. Date: 1997-10-27; US1996-643284 Applic. Date: 1996-05-08; US1996-646572 Applic. Date: 1996-05-08; US1994-239635 Applic. Date: 1994-05-09

Inventor: BUNQER ROLF [US]


Application No.: US20090156982A1  Published: 18/Jun/2009

Title: Transdermal treatment device and method

Applicant/Assignee:

Application No.: 12/231798   Filing Date: 05/Sep/2008

Abstract:A treatment device for treating a medical condition comprises a composition selected for its ability to treat the medical condition, the composition being formulated for transdermal delivery. A portable container is provided which comprises a body for accommodating the composition in a sealed arrangement, a frangible seal on the container which can be ruptured to enable discharge of the composition from the body, and an application component on the container for facilitating transdermal delivery of the composition.

Priority: US20070967766P Applic. Date: 2007-09-06

Inventor: PETRIE AREZOU [US]; PETRIE LOUIS [US]; ROY XAVIER [US]


Application No.: US20090158595A1  Published: 25/Jun/2009

Title: Microemulsion and Shaving Apparatus Comprising a Microemulsion

Applicant/Assignee:

Application No.: 12/083470   Filing Date: 16/Oct/2006

Abstract:A microemulsion comprising an oil phase, an aqueous phase, a surfactant, and a hair modification active. The microemulsion is suitable for being impregnated therein or deposited thereon a substrate.

Priority: GB20050020931 Applic. Date: 2005-10-14; WO2006GB03814 Applic. Date: 2006-10-16

Inventor: ACHER DAVID [GB]; ELLIS PAUL [GB]; HEESON TRACEY [GB]


Application No.: US20090162304A1  Published: 25/Jun/2009

Title: COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS IN MAMMALS

Applicant/Assignee:

Application No.: 11/961333   Filing Date: 20/Dec/2007

Abstract:A topical composition for treating skin diseases is provided. The composition comprises calendula, tea tree oil, eucalyptus oil, grape seed oil, and Aloe vera. In some embodiment, the composition may also include beeswax, vegetable oil, vitamin E, rosemary oil, or shea butter or combinations thereof to further enhance its beneficial effects. In some embodiments, the composition may also include herbs. Kits and methods for treatment of skin diseases are also disclosed.

Priority:

Inventor: DILEVA ROSE MARIE [US]


Application No.: US20090162335A1  Published: 25/Jun/2009

Title: MELATONIN AND IMMUNOSTIMULATING SUBSTANCE-BASED COMPOSITIONS

Applicant/Assignee: MAVI SUD S.R.L

Application No.: 12/281523   Filing Date: 02/Mar/2007

Abstract:The present invention relates to synergistic associations of melatonin and other active substances and cosmetic compositions suitable for treating all those manifestations causing or accompanying the aging of skin, hair and other tissues. In particular, the invention is based on the use of melatonin associated with immunoactive and antioxidant substances significantly potentiating its antiaging activity, remarkably reducing free radical formation and thereby improving the aspect of both skin and hair.

Priority: IT2006RM00108 Applic. Date: 2006-03-03; WO2007EP52026 Applic. Date: 2007-03-02

Inventor: MORGANTI PIERFRANCESCO [IT]


Application No.: US20090162437A1  Published: 25/Jun/2009

Title: Modified self-assembling peptides

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 11/904278   Filing Date: 26/Sep/2007

Abstract:The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form

and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as "modified self-assembling peptides." The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.

Priority: US20060847303P Applic. Date: 2006-09-26

Inventor: HORII AKIHIRO [JP]; ZHANG SHUGUANG [US]; WANG XIUMEI [CN]; GELAIN FABRIZIO [IT]


Application No.: US20090162443A1  Published: 25/Jun/2009

Title: COMPOSITIONS AND METHODS FOR REDUCING OR PREVENTING WATER LOSS FROM THE SKIN

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 12/338033   Filing Date: 18/Dec/2008

Abstract:Moisturizing compositions comprising microspheres for the purpose of preventing or reducing moisture loss from the skin.

Priority: US20070015895P Applic. Date: 2007-12-21

Inventor: ANTHONY FRANK A [US]; ERIXON ANNA KNAPP [US]; WRIGHT COURTNEY DENISE [US]


Application No.: US20090163577A1  Published: 25/Jun/2009

Title: METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS

Applicant/Assignee: BURNHAM INSTITUTE FOR MEDICAL RESEARCH

Application No.: 12/325315   Filing Date: 01/Dec/2008

Abstract:The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family of proteins and neutralizes the ability of these proteins to suppress release of apoptogenic proteins from isolated mitochondria. Structure-function analysis of GA using analogs suggested a general correlation between BH3 competition and cytoxicity activity. Compositions and methods are provided for using GA and its derivatives for treating cancer and for discovering other compounds that are useful for treating cancer through their interaction with Bcl-2-family proteins.

Priority: US20070005303P Applic. Date: 2007-12-03

Inventor: REED JOHN C [US]; ZHAI DAYONG [US]


Application No.: US20090163602A1  Published: 25/Jun/2009

Title: SILICONE CONTAINING POLYMERIC MATERIALS

Applicant/Assignee: ADVANCED MEDICAL OPTICS, INC

Application No.: 11/963351   Filing Date: 21/Dec/2007

Abstract:A polymeric material with a variable modulus of elasticity is described herein. The polymeric material described herein is useful for forming implantable medical devices (e.g. ophthalmic lenses, breast implants, and body augmentation devices). In addition, medical devices formed from the polymer material can be used to controllably release a therapeutic agent. Also, the polymeric material may be used to prepare topical compositions or other applications or devices where control of a mechanical property such as material modulus is important.

Priority:

Inventor: HU CAN B [US]; MAI THUY B [US]


Application No.: US20090165327A1  Published: 02/Jul/2009

Title: Method of de-wrinkling garments and device for facilitating same

Applicant/Assignee:

Application No.: 12/317717   Filing Date: 22/Dec/2008

Abstract:A device and process for conveniently removing wrinkles from dried clothes. The inventive device includes an outer shell enclosing a core of water absorbent material. The device may be spherical, cubic, or be in other regular or irregular geometric shapes, having a finish that would not damage or affect the tumbling of clothes in the dryer. The foam material in the shell is saturated with water prior to tossing into the clothes dryer with the clothes to be de-wrinkled. Moisture from the foam material in the shell is introduced into the dryer chamber from the dryer heat, which relaxes wrinkles on clothing.

Priority: US20070008760P Applic. Date: 2007-12-21

Inventor: NEKOVAR JACQUELYN [US]


Application No.: US20090169472A1  Published: 02/Jul/2009

Title: METHODS AND COMPOSITIONS FOR TREATING IMMUNE DISORDERS

Applicant/Assignee: CANCER RESEARCH TECHNOLOGY LTD

Application No.: 12/088752   Filing Date: 12/Oct/2006

Abstract:The present invention provides oligonucleotides, compositions comprising them and methods that use the oligonucleotides and compositions for stimulating cells expressing the TLR7 and/or TLR8 receptor. The oligonucleotides comprise for stimulating TLR7 comprise uracil-rich regions. The oligonucleotides for stimulating TLR8 comprise guanine-rich regions. The present methods and compositions are useful, inter alia, for treating or preventing conditions such as infectious disease and cancer.

Priority: US20050726305P Applic. Date: 2005-10-12; US20050751917P Applic. Date: 2005-12-20; WO2006EP67334 Applic. Date: 2006-10-12

Inventor: DIEBOLD SANDRA [GB]; REIS E SOUSA CAETANO [GB]; PATUREL CARINE [FR]


Application No.: US20090169486A1  Published: 02/Jul/2009

Title: BIOMEDICAL FOAM ARTICLES

Applicant/Assignee: BAYER BUSINESS SERVICES GMBH

Application No.: 12/296380   Filing Date: 05/Apr/2007

Abstract:The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.

Priority: DE200610016636 Applic. Date: 2006-04-08; WO2007EP03077 Applic. Date: 2007-04-05

Inventor: DIETZE MELITA [DE]; FUGMANN BURKHARD [DE]; MAGER MICHAEL [DE]; RISCHE THORSTEN [DE]; HECKES MICHAEL [DE]; RUDHARDT DANIEL [DE]; GERTZMANN ROLF [DE]


Application No.: US20090169487A1  Published: 02/Jul/2009

Title: Essential Oil Diffusion

Applicant/Assignee:

Application No.: 12/345556   Filing Date: 29/Dec/2008

Abstract:A method for treating and/or alleviating at least one symptom associated with impaired airway clearance of mucous, impaired oxygen intake, and/or infection in a patient suffering from a respiratory ailment and/or restrictive lung disease includes administering to the patient an effective amount of an essential oil composition including at least one essential oil selected from Lavandula latifolia (spike lavender), Thymus mastichina (Spanish marjoram)

Abies balsamea (balsam fir)

and Menthaxpiperita (peppermint). The symptoms associated with impaired airway clearance, impaired oxygen intake, and/or infection can be alleviated via passive or active inhalation of the essential oil composition.

Priority: US20070017508P Applic. Date: 2007-12-28

Inventor: HEDAYAT KAMYAR MALEK [US]


Application No.: US20090169491A1  Published: 02/Jul/2009

Title: Peptides Having Activities of Insulin Like Growth Factor-1 and their Uses

Applicant/Assignee: CAREGEN CO., LTD

Application No.: 12/224788   Filing Date: 06/Mar/2007

Abstract:The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

Priority: KR20060021099 Applic. Date: 2006-03-06; WO2007KR01086 Applic. Date: 2007-03-06

Inventor: CHUNG YONG JI [KR]; KIM YOUNG DEUG [KR]; KIM EUN MI [KR]


Application No.: US20090169500A1  Published: 02/Jul/2009

Title: PERSONAL CARE COMPOSITIONS

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 12/400309   Filing Date: 09/Mar/2009

Abstract:This invention relates to personal care compositions containing polytrimethylene ether glycol in a variety of physical forms including solutions, gels, oil-in-water emulsions, water-in-oil emulsions, suspensions and solids. In a particularly preferred embodiment, the polytrimethylene ether glycol is derived predominantly from monomers obtained from renewable resources, making the personal care products of this embodiment of the present invention more environmentally friendly in terms of their manufacture, use and disposal.

Priority: US2007-801872 Applic. Date: 2007-05-11; US20060801166P Applic. Date: 2006-05-17

Inventor: SUNKARA HARI BABU [US]


Application No.: US20090169520A1  Published: 02/Jul/2009

Title: Compounds, Pharmaceutical Compositions and Therapeutic Methods of Preventing and Treating Diseases and Disorders Associated With Amyloid Fibril Formation

Applicant/Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM

Application No.: 10/585695   Filing Date: 09/Jan/2005

Abstract:Compounds, pharmaceutical compositions and methods for prevention and/or reversal of amyloid fibril formation and treating amyloid-related disorders are provided. Also provided a method of limiting and/or reducing inflammation.

Priority: WO2005IL00028 Applic. Date: 2005-01-09; US20040535203P Applic. Date: 2004-01-09

Inventor: SOREQ HERMONA [IL]; DIAMANT SOPHIE [IL]


Application No.: US20090169523A1  Published: 02/Jul/2009

Title: HSC SELF-RENEWAL

Applicant/Assignee:

Application No.: 12/268320   Filing Date: 10/Nov/2008

Abstract:The invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC expansion and the use of RASSF8 to increase the retention and/or expansion of KLS cells in vitro. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of disorders or diseases (e.g. leukemia). The invention also relates to the development of small molecules that may increase HSC self renewal in vitro and in vivo.

Priority: US2006-452081 Applic. Date: 2006-06-13; US20050690089P Applic. Date: 2005-06-13

Inventor: VERFAILLIE CATHERINE [BE]; SCHOEMANS HELENE [BE]; SNOECKX RIKKERT [BE]


Application No.: US20090169588A1  Published: 02/Jul/2009

Title: Compositions Containing Proteins for the Transfer/Recycling of Structurally Modified Lipids, and the Applications Thereof

Applicant/Assignee: MERZ PHARMA GMBH & CO. KGAA

Application No.: 12/085095   Filing Date: 24/Oct/2006

Abstract:The invention relates to compositions containing recycling/transfer proteins for structurally/functionally modified lipids, a lipid depot of structurally non-modified lipids, and non-transferable active ingredients. Such compositions can be used for the engineering of biomembranes, e.g. by external topical application, especially to the skin/mucous membranes. Structurally or functionally, especially oxidatively modified, lipids are removed from the structures containing the same, such as lipid aggregates of the skin, are externally regenerated in a depot, and preferably introduced back into the structures. The invention also relates to the recycling of modified lipids of biomembranes. The inventive compositions are self-regulative and can be especially applied in a cosmetic, cosmetic balneological or dermatological/pharmaceutical manner.

Priority: DE200510056538 Applic. Date: 2005-11-28; WO2006EP10223 Applic. Date: 2006-10-24

Inventor: BEUTLER ROLF D [DE]; SCHMIDT KARLHEINZ [DE]


Application No.: US20090169607A1  Published: 02/Jul/2009

Title: Pharmaceutical Compositions Comprising Cyclosporin

Applicant/Assignee: PARI PHARMA GMBH

Application No.: 12/086141   Filing Date: 29/Nov/2006

Abstract:The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin

b) an aqueous carrier liquid

c) a first solubilizing substance selected among the group of phospholipids

and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.

Priority: DE200510058252 Applic. Date: 2005-12-06; DE200610051512 Applic. Date: 2006-10-31; WO2006EP11459 Applic. Date: 2006-11-29

Inventor: KELLER MANFRED [DE]; AKKAR ASLIHAN [DE]


Application No.: US20090169608A1  Published: 02/Jul/2009

Title: TOPICALLY APPLICABLE COMPOSITION FOR USE AS A SKIN BLEACHING AGENT

Applicant/Assignee: DSM IP ASSETS B.V

Application No.: 12/089654   Filing Date: 09/Oct/2006

Abstract:Topical composition for use especially as a skin lightener, characterized in that it contains an effective amount of at least one compound of general formula (I) or a mixture of such compounds and/or an acid addition salt thereof: in which X is NH or a direct bond and n is 2, 3 or 4, preferably 2 or 3, and its use for lightening skin colour, for depigmenting liver spots and for evening out non-uniformities in skin colouration. The invention further relates to dermatologically effective compositions containing at least one disulfide of general formula (I) and at least one additional skin care ingredient.

Priority: CH20050001656 Applic. Date: 2005-10-12; WO2006CH00555 Applic. Date: 2006-10-09

Inventor: ZIEGLER HUGO [CH]; WIKSTROEM PETER [CH]; STOCKLI MARTIN [CH]


Application No.: US20090169609A1  Published: 02/Jul/2009

Title: PQS AND ITS CONJUGATES AS ADJUVANTS AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS

Applicant/Assignee: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMGB

Application No.: 12/092518   Filing Date: 08/Nov/2006

Abstract:The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP20050024266 Applic. Date: 2005-11-08; WO2006EP10699 Applic. Date: 2006-11-08

Inventor: EBENSEN THOMAS [DE]; MORR MICHAEL [DE]; GUZMAN CARLOS A [DE]


Application No.: US20090169623A1  Published: 02/Jul/2009

Title: Use of ginsenosides and extracts containing them

Applicant/Assignee:

Application No.: 12/291782   Filing Date: 13/Nov/2008

Abstract:The present invention relates to the use of ginsenosides and a plant extract containing ginsenosides in a cosmetic or pharmaceutical composition or in a food supplement for the protection of the skin against deleterious effects of stress or irradiation e.g. sunlight or UV irradiation.

Priority: EP20060290814 Applic. Date: 2006-05-17

Inventor: SENE GERARD [FR]; LOISEAU ALAIN [FR]; MEYBECK ALAIN [FR]; YANG CHONG REN [CN]


Application No.: US20090169652A1  Published: 02/Jul/2009

Title: Personal Care Compositions

Applicant/Assignee:

Application No.: 12/274865   Filing Date: 20/Nov/2008

Abstract:Personal care compositions comprising an active component, use of such compositions, and methods of marketing such compositions. The personal care compositions can be applied topically, ingested orally, injected, or used as part of a regimen.

Priority: US20070991005P Applic. Date: 2007-11-29

Inventor: OSBORNE ROSEMARIE [US]


Application No.: US20090170788A1  Published: 02/Jul/2009

Title: NOVEL USE OF 1, 2, 3, 4, 6-PENTA-O-GALLOYL-BETA-D-GLUCOSE

Applicant/Assignee:

Application No.: 12/161164   Filing Date: 16/Jan/2007

Abstract:The present invention relates to novel use of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose. More particularly, the present invention relates to a pharmaceutical composition and cosmetic composition for preventing and treating skin disease, comprising 1,2,3,4,6-penta-O-galloyl-beta-D-glucose represented by formula 1 as an active ingredient. Also, the invention relates to a method for preventing and treating skin disease using 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, and to the use of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose.

Priority: KR20060004403 Applic. Date: 2006-01-16; WO2007KR00266 Applic. Date: 2007-01-16

Inventor: SHIN DONG-HEON [KR]


Application No.: US20090170917A1  Published: 02/Jul/2009

Title: Acid Mimic Compounds for the Inhibition of Isoprenyl-S-Cysteinyl Methyltransferase

Applicant/Assignee:

Application No.: 12/326746   Filing Date: 02/Dec/2008

Abstract:Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).

Priority: US20070005129P Applic. Date: 2007-12-03; US20070005866P Applic. Date: 2007-12-07; US20070007234P Applic. Date: 2007-12-10

Inventor: LEE SEUNG-YUB [US]; PEREZ EDUARDO [US]; RAPOLE KESHAVA [US]; SARNGADHARAN GOPAL [US]; STOCK GREGORY B [US]; STOCK JEFFRY B [US]; STOCK MAXWELL [US]; VORONKOV MICHAEL [US]; WOLANIN PETER [US]


Application No.: US20090172978A1  Published: 09/Jul/2009

Title: Merchandising Systems, Methods of Merchandising, and Point-Of-Sale Devices Comprising Micro-Optics Technology

Applicant/Assignee: NANOVENTIONS HOLDINGS, LLC

Application No.: 11/969625   Filing Date: 04/Jan/2008

Abstract:A merchandising system, including: a consumer product. The merchandising system includes at least one of the consumer product, packaging for the consumer product, and advertisement material pertaining to the consumer product. At least one element of the merchandising system includes indicia and/or an image that relates, or is analogous to, an attribute and/or targeted benefit of the consumer product. At least one element of the merchandising system further includes a micro-optic structure capable of controlling the scatter of light impinging thereon so that the micro-optic structure reflects and/or transmits light in a field of view over which at least a portion of the indicia and/or image appears brighter relative to that outside the field of view.

Priority:

Inventor: STEENBLIK RICHARD A [US]; HURT MARK J [US]; JORDAN GREGORY R [US]; MARTIN BRIAN S [US]; SUSONG JENNIFER [US]


Application No.: US20090173654A1  Published: 09/Jul/2009

Title: Merchandising Systems, Methods of Merchandising, and Point-Of-Sale Devices Comprising Micro-Optics Technology

Applicant/Assignee: NANOVENTIONS HOLDINGS, LLC

Application No.: 11/969614   Filing Date: 04/Jan/2008

Abstract:A merchandising system, including: a consumer product. The merchandising system includes at least one of the consumer product, packaging for the consumer product, and advertisement material pertaining to the consumer product. At least one element of the merchandising system includes indicia and/or an image that relates, or is analogous to, an attribute and/or targeted benefit of the consumer product. At least one element of the merchandising system further includes a micro-optic structure capable of controlling the scatter of light impinging thereon so that the micro-optic structure reflects and/or transmits light in a field of view over which at least a portion of the indicia and/or image appears brighter relative to that outside the field of view.

Priority:

Inventor: STEENBLIK RICHARD A [US]; HURT MARK J [US]; JORDAN GREGORY R [US]; MARTIN BRIAN S [US]; SUSONG JENNIFER [US]


Application No.: US20090173658A1  Published: 09/Jul/2009

Title: COSMETIC MASK PACKAGE

Applicant/Assignee:

Application No.: 12/107942   Filing Date: 23/Apr/2008

Abstract:A cosmetic mask package has an outer pouch, a liquid storing device and a carrier. The outer pouch has an interior surface defining an inner space. The liquid storing device is mounted in the inner space inside the outer pouch and has an inner pouch filled with liquid and a pointed instrument selectively piercing the inner pouch to release the liquid. The carrier is dry to prevent microorganism growth and is mounted in the inner space inside the outer pouch and outside the inner pouch. When the inner pouch is pierced, the carrier is moistened for use. Additional preservatives are not required so the masks are hypoallergenic and hygienic.

Priority: TW20080200405U Applic. Date: 2008-01-08

Inventor: WANG CHU-HUI [TW]


Application No.: US20090175804A1  Published: 09/Jul/2009

Title: Preparation of cationic terpolymers and personal care compositions comprising said terpolymers

Applicant/Assignee:

Application No.: 12/317023   Filing Date: 18/Dec/2008

Abstract:The present invention is directed to cationic terpolymers, methods to make them, and the use of compositions containing said terpolymers in personal care compositions. The polymers are useful in personal care applications. The cationic terpolymers of this present invention provide the extra conditioning benefits required in a personal care product. These cationic terpolymers also contribute useful conditioning properties to hair-care and skin-care products.

Priority: US20070008350P Applic. Date: 2007-12-20

Inventor: JENNINGS JOHN [IE]; ZHOU XIAN-ZHI [US]


Application No.: US20090175808A1  Published: 09/Jul/2009

Title: COMPOSITION AND USES THEREOF

Applicant/Assignee: THE BOOTS COMPANY PLC

Application No.: 12/297101   Filing Date: 13/Apr/2007

Abstract:Use of a composition comprising oil bodies in the preparation of a formulation for administration to a mammal wherein said composition comprises oil curd extracted from oleaginous plant tissue, said oil curd comprising an aqueous dispersion of oil bodies and associated extrinsic protein material. Preferably, the oil curd is extracted from seed material selected from flax, sunflower, sesame, hemp, pumpkin, oilseed rape, camelina, cranberry, safflower, rosehip, blackcurrant, evening primrose, borage, meadowfoam, grapeseed and jojoba. The composition has useful properties in improving the stability of formulations, in particular in emulsifying such formulations and in improving the aesthetic acceptability of a formulation. Also, the compositions are useful in the delivery of actives into the skin &/or hair and in the regulation of the condition of the skin &/or hair. Processes for the preparation of said composition and formulations are also disclosed.

Priority: GB20060007478 Applic. Date: 2006-04-13; GB20070001713 Applic. Date: 2007-01-30; US20070898404P Applic. Date: 2007-01-31; WO2007GB50194 Applic. Date: 2007-04-13

Inventor: GALLEY EDWARD [GB]; GRAY DAVID ALISTAIR [GB]; LONG STEWART PAUL [GB]; WHITE DANIEL ALLAN [GB]; PALIN JANET [GB]


Application No.: US20090175830A1  Published: 09/Jul/2009

Title: ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES

Applicant/Assignee:

Application No.: 12/370232   Filing Date: 12/Feb/2009

Abstract:The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.

Priority: US2005-077513 Applic. Date: 2005-03-10; US20040551932P Applic. Date: 2004-03-10

Inventor: FUEYO JUAN [US]; GOMEZ-MANZANO CANDELARIA [US]; YUNG W K ALFRED [US]; CONRAD CHARLES A [US]; LANG JR FREDERICK F [US]


Application No.: US20090175870A1  Published: 09/Jul/2009

Title: YKL-40 MONOCLONAL AUTHORITY

Applicant/Assignee:

Application No.: 11/817244   Filing Date: 16/Feb/2006

Abstract:The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.

Priority: DK20050000300 Applic. Date: 2005-02-28; WO2006DK00093 Applic. Date: 2006-02-16

Inventor: BONNICHSEN RICHARD [SC]; PRICE PAUL [US]


Application No.: US20090175928A1  Published: 09/Jul/2009

Title: Lip Plaster

Applicant/Assignee:

Application No.: 12/083736   Filing Date: 09/Oct/2006

Abstract:The invention relates to a self-adhesive lip plaster which comprises at least one single-layered matrix and which contains at least one antiviral active medical substance for using in the event of Herpes labialis. Said matrix is arranged on a flexible carrier film which is hydrophobic and also permeable to vapor.

Priority: DE200510050654 Applic. Date: 2005-10-20; WO2006DE01768 Applic. Date: 2006-10-09

Inventor: MAIER STEPHAN [DE]; VOLLMER ULRIKE [DE]


Application No.: US20090176204A1  Published: 09/Jul/2009

Title: Method for improved diagnosis of dysplasias

Applicant/Assignee:

Application No.: 12/381098   Filing Date: 06/Mar/2009

Abstract:The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Priority: EP20020024030 Applic. Date: 2002-10-28; EP20030100584 Applic. Date: 2003-03-07; US2003-533384 Applic. Date: 2003-10-21; WO2003EP50738 Applic. Date: 2003-10-21

Inventor: RIDDER RUEDIGER [DE]; REICHERT ANJA [DE]; TRUNK-GEHMACHER MARCUS [DE]; BATRLA RICHARD [DE]


Application No.: US20090176291A1  Published: 09/Jul/2009

Title: LAUNDRY DETERGENT COMPOSITION COMPRISING A GLYCOSYL HYDROLASE AND A BENEFIT AGENT CONTAINING DELIVERY PARTICLE

Applicant/Assignee:

Application No.: 12/341730   Filing Date: 22/Dec/2008

Abstract:The present invention relates to a laundry detergent composition comprising a glycosyl hydrolase and a benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions.

Priority: US20080010112P Applic. Date: 2008-01-04; US20080114584P Applic. Date: 2008-11-14

Inventor: BOUTIQUE JEAN-POL [BE]; VANWYNGAERDEN NATHALIE JEAN MA [BE]; LANT NEIL JOSEPH [GB]; SOUTER PHILIP FRANK [GB]; SADLOWSKI EUGENE STEVEN [US]; WENNING GENEVIEVE CAGALAWAN [US]


Application No.: US20090176724A1  Published: 09/Jul/2009

Title: Methods and Compositions for the Diagnosis, Prognosis and Treatment of Cancer

Applicant/Assignee:

Application No.: 11/571585   Filing Date: 30/Jun/2005

Abstract:The invention is relates to splice variants of basal transcription factors and other transcriptional modulators, the use of expression analyses of the same as a diagnostic and prognostic tool, and the targeting of such splice variants for therapeutic purposes, particularly in relation to the treatment of cancer.

Priority: US20040584784P Applic. Date: 2004-06-30; WO2005US23708 Applic. Date: 2005-06-30

Inventor: SHEN DAIWEI [US]; NEUMAN TOOMAS [US]; PALM KAIA [EE]


Application No.: US20090176733A1  Published: 09/Jul/2009

Title: Novel Medicaments for Anti-Herpes Virus Treatments

Applicant/Assignee: LABORATOIRE DE LA MER

Application No.: 12/299365   Filing Date: 03/May/2007

Abstract:The invention concerns the use of a sulphated or phosphated polysaccharide for preparing a drug for treating herpes virus mediated diseases, more particularly mediated by alpha-herpes viruses, and in particular by HSV-1 and HSV-2, as well as by strains of those viruses which are resistant to known antiviral agents. The polysaccharide is preferably sulphated laminarin PS3.

Priority: WO2007FR00761 Applic. Date: 2007-05-03; FR20060003990 Applic. Date: 2006-05-04

Inventor: BOURGOUGNON NATHALIE [FR]; YVIN JEAN-CLAUDE [FR]


Application No.: US20090176803A1  Published: 09/Jul/2009

Title: CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS

Applicant/Assignee:

Application No.: 12/305584   Filing Date: 19/Jun/2007

Abstract:The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2

R2 represents: hydrogen or halogen

n represents: 1 or 2

R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls

or a cyclohexyl

as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.

Priority: FR20060005419 Applic. Date: 2006-06-19; WO2007EP56086 Applic. Date: 2007-06-19

Inventor: PEREZ MICHEL [FR]; LAMOTHE MARIE [FR]; LE GRAND BRUNO [FR]; LETIENNE ROBERT [FR]


Application No.: US20090176810A1  Published: 09/Jul/2009

Title: COMPOSITION FOR SKIN EXTERNAL APPLICATION CONTAINING GALLOCATECHIN GALLATE FOR MOISTURIZING EFFECT ON THE SKIN

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 12/064997   Filing Date: 08/Sep/2006

Abstract:The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-alpha), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.

Priority: KR20050086821 Applic. Date: 2005-09-16; WO2006KR03579 Applic. Date: 2006-09-08

Inventor: SHIN HYUN JUNG [KR]; KIM JEONG KI [KR]; KIM SU NAM [KR]; LEE SANG MIN [KR]; LEE BYEONG GON [KR]; CHANG IH SEOP [KR]


Application No.: US20090176841A1  Published: 09/Jul/2009

Title: NOVEL 6-5 SYSTEM BICYCLIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY

Applicant/Assignee: SANWA KAGAKU KENKYUSHO CO., LTD

Application No.: 12/342729   Filing Date: 23/Dec/2008

Abstract:An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: [wherein [Chemical Formula 2] is a single bond or a double bond

A is -CH2- or -CO-

X, Y, and Z are each independently a nitrogen atom or a carbon atom

R1 is a hydrogen atom or an aralkyl group

R2 is an alkyl group or an aralkyl group, etc.

R3 is a hydrogen atom or an alkyl group, etc.

R4 is a hydrogen atom or an alkyl group

R5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.

R6 is a hydrogen atom or an alkyl group

R7 is a hydrogen atom, etc.

R8 is a hydrogen atom, or an alkyl group, etc.

and E is -NHCO-G-COR12, etc. (wherein G is a single bond or an alkylene group, and R12 is a hydroxy group or an alkoxy group)].

Priority: JP20060178548 Applic. Date: 2006-06-28; WO2007JP63612 Applic. Date: 2007-06-27

Inventor: ASANO YUKIYASU [JP]; MAEDA KOJI [JP]; TSURUTA NOBUAKI [JP]; MURASE TORU [JP]


Application No.: US20090176881A1  Published: 09/Jul/2009

Title: Unsaturated Alkyl Esters of 5-Aminolevulinic Acid, their Preparation and their Use

Applicant/Assignee:

Application No.: 12/227085   Filing Date: 28/Jun/2007

Abstract:Disclosed are unsaturated alkyl esters of 5-aminovulinic acid of the following chemical formula 1, or pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof. [Chemical Formula I] NH2-CH2-CO-CH2-CH2-CO-O-R wherein, R is a group selected from a group consisting of 2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, cis-2-pentenyl, cis-3-hexenyl, cis-4-hexenyl, and trans-2-hexenyl. Also, a pharmaceutical composition comprising the unsaturated alkyl ester of 5-aminovulinic acid or a salt thereof as an active ingredient is provided. This pharmaceutical composition is easily absorbed transdermally and is of low cytotoxicity. Featuring no amino-protecting processes, the method guarantees high production yields.

Priority: KR20060059124 Applic. Date: 2006-06-29; KR20070040869 Applic. Date: 2007-04-26; WO2007KR03145 Applic. Date: 2007-06-28

Inventor: OH JONGHOON [KR]; LEE JEE-BUM [KR]; PARK HYOUNG-RYUN [KR]


Application No.: US20090177496A1  Published: 09/Jul/2009

Title: Relationship prediction system

Applicant/Assignee:

Application No.: 12/313263   Filing Date: 17/Nov/2008

Abstract:A Relationship Prediction System for providing a relationship prediction based on the correlation of personal characteristics and the analysis of genetic characteristics is disclosed. In one embodiment, a first person supplies descriptions of their own personal characteristics, as well as descriptions of the personal characteristics of their ideal match, to a website. The first person also furnishes an odor, tissue or fluid sample to a test facility, where genetic characteristics are analyzed and determined. A relationship match is then generated based on both a combination of both a positive correlation of the personal characteristics of the first person and second person, and a measured dissimilarity between the sequence of genetic characteristics of the first person and second person.

Priority: US2005-239603 Applic. Date: 2005-09-28; US2005-286143 Applic. Date: 2005-11-23; US2006-360025 Applic. Date: 2006-02-21; US2006-405001 Applic. Date: 2006-04-14; US2006-514285 Applic. Date: 2006-08-30; US2007-881153 Applic. Date: 2007-07-24; WO2006GB03581 Applic. Date: 2006-09-26; WO2007GB02836 Applic. Date: 2007-07-26

Inventor: TUCK EDWARD F [US]; HASELTON MARTIE G [US]; GARVER-APGAR CHRISTINE E [US]


Application No.: US20090181024A1  Published: 16/Jul/2009

Title: NOVEL COMPOSITION AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES

Applicant/Assignee: GENENTECH, INC

Application No.: 11/537270   Filing Date: 29/Sep/2006

Abstract:The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US2003-658482 Applic. Date: 2003-09-09; US20020410062P Applic. Date: 2002-09-11

Inventor: BALDWIN DARYL T [US]; BODARY SARAH C [US]; CHAN ANDREW C [US]; CLARK HILARY [US]; JACKMAN JANET K [US]; WOOD WILLIAM I [US]


Application No.: US20090181069A1  Published: 16/Jul/2009

Title: THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM

Applicant/Assignee: MONOSOL RX, LLC

Application No.: 12/411505   Filing Date: 26/Mar/2009

Abstract:The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.

Priority: US2008-128950 Applic. Date: 2008-05-29; US2006-473356 Applic. Date: 2006-06-22; US2002-074272 Applic. Date: 2002-02-14; US20010328868P Applic. Date: 2001-10-12

Inventor: YANG ROBERT K [US]; FUISZ RICHARD C [US]; MYERS GARRY L [US]; FUISZ JOSEPH M [US]


Application No.: US20090181075A1  Published: 16/Jul/2009

Title: DROSPIRENONE CONTAINING TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS OF DELIVERY THEREOF

Applicant/Assignee:

Application No.: 11/995767   Filing Date: 13/Jul/2006

Abstract:A transdermal drug delivery device comprising an adhesive matrix, an effective amount of drospirenone, and an oligomeric adjuvant selected from an oligolactic acid, oligolactic acid derivatives, or mixtures thereof. Also, a transdermal drug delivery device comprising a backing film and an adhesive matrix which comprises an effective amount of drospirenone, a solubilizing agent, and a permeation enhancer selected from the group consisting of alkyl lactates, carboxylic acids, alkyl esters of fatty acids, and mixtures thereof.

Priority: US20050699696P Applic. Date: 2005-07-15; US20050730296P Applic. Date: 2005-10-26; US20060747217P Applic. Date: 2006-05-15; WO2006US27458 Applic. Date: 2006-07-13

Inventor: GORDON RYAN D [US]; SEILER PETER M [US]; LANDIN DONALD T [US]; BRACHT STEFAN [DE]; EDER WOLFGANG [DE]


Application No.: US20090181076A1  Published: 16/Jul/2009

Title: Drug Release From Nanoparticle-Coated Capsules

Applicant/Assignee: UNIVERSITY OF SOUTH AUSTRALIA

Application No.: 12/299063   Filing Date: 04/May/2007

Abstract:Methods of producing a controlled release formulation for an active substance are disclosed, wherein the methods involve dispersing a discontinuous phase comprising an active substance into a continuous phase so as to form a two-phase liquid system comprising droplets of said discontinuous phase, and allowing nanoparticles provided to the two-phase liquid system to congregate at the phase interface to thereby coat the surface of the droplets in at least one layer of said nanoparticles. The methods utilise a concentration of a suitable electrolyte which enhances the nanoparticle congregation such that the coating of nanoparticles on the surface of the droplets presents a semi-permeable barrier to the active substance, or otherwise utilise a amount of the active substance that is greater than the solubility limit of that active substance in the discontinous phase. Formulations comprising vitamin A (retinol) as the active substance for dermal delivery are specifically exemplified.

Priority: AU20060902311 Applic. Date: 2006-05-04; AU20060906840 Applic. Date: 2006-12-07; WO2007AU00602 Applic. Date: 2007-05-04

Inventor: PRESTIDGE CLIVE ALLAN [AU]; SIMOVIC SPOMENKA [AU]; GHOUCHI ESKANDAR NASRIN [AU]


Application No.: US20090181888A1  Published: 16/Jul/2009

Title: Skin Repair Accelerating Therapeutic Agent Containing Ghrelin and Derivatives Thereof or Substance Acting On GHS-R1a as Active Ingredient

Applicant/Assignee:

Application No.: 12/085221   Filing Date: 21/Nov/2006

Abstract:The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing a substance acting on a growth hormone secretagogue receptor or a pharmaceutically acceptable salt thereof as an active ingredient.

Priority: JP20050336418 Applic. Date: 2005-11-21; WO2006JP323226 Applic. Date: 2006-11-21

Inventor: MURAKAMI NOBORU [JP]; NAKAHARA KEIKO [JP]; KANGAWA KENJI [JP]; HAYASHI YUJIRO [JP]


Application No.: US20090186043A1  Published: 23/Jul/2009

Title: Method and compositions for preventing and treating streptococcus pneumoniae infection

Applicant/Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY MOR RESEARCH APPLICATIONS LTD

Application No.: 12/285115   Filing Date: 29/Sep/2008

Abstract:A method of preventing and/or treating S. pneumoniae infection in mammalian subjects, wherein said method comprises administering to said subjects a composition comprising one or more agents that are capable of inhibiting the binding of the S. pneumoniae cell wall protein FBA to the respiratory tract cells of said subject.

Priority: WO2007IL00421 Applic. Date: 2007-03-29; US20060787163P Applic. Date: 2006-03-30

Inventor: MIZRACHI NEBENZAHL YAFFA [IL]; DAGAN RON [IL]


Application No.: US20090186072A1  Published: 23/Jul/2009

Title: Operational status for active transdermal medicament patch

Applicant/Assignee: ACTIVA TEK, INC

Application No.: 12/009443   Filing Date: 18/Jan/2008

Abstract:An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

Priority:

Inventor: YANAKI JAMAL S [US]


Application No.: US20090186096A1  Published: 23/Jul/2009

Title: Applications of microencapsulated essential oils

Applicant/Assignee: BOTANOCAP LTD

Application No.: 12/222741   Filing Date: 14/Aug/2008

Abstract:A new method for the preparation of microencapsulated essential oils is disclosed. The microcapsules containing essential oils or a formulation containing thereof may be used for various non-agricultural applications.

Priority: WO2007IL00213 Applic. Date: 2007-02-15; US20060773313P Applic. Date: 2006-02-15; US20060873939P Applic. Date: 2006-12-11; US20080087755P Applic. Date: 2008-08-11

Inventor: KRITZMAN AMNON [IL]; MARKUS ARIE [IL]; STRONGIN PNINA [IL]; LINDER CHARLES [IL]


Application No.: US20090186111A1  Published: 23/Jul/2009

Title: Novel Bacteria and Pharmaceutically Active Products Obtained Therefrom

Applicant/Assignee:

Application No.: 11/658686   Filing Date: 24/Jul/2005

Abstract:A substance obtainable from Staphylococcus Aureus bacteria or from a Staphylococcus Aureus bacteria culture, the substance characterized in having at least one of the following characteristics: (a) stimulates proliferation of bovine T-lymphocytes in vitro

(b) accelerates healing of skin wounds in mice and pigs

(c) prevents AIDS-like disease (ALD) in mice infected with ALD virus (ALD-V) when injected substantially simultaneously with the virus

and (d) reduces the viral load in Rhesus Macaques infected with the hybrid simian/human immunodeficiency virus (SHIV) when injected into chronically infected Macaques, or a derivative or fraction of said substance which retains at least one of the characteristics of the substance. Also disclosed is a novel Staphylococcus Aureus bacteria, and a pharmaceutical composition comprising as active ingredient the substance and a pharmaceutically acceptable excipient.

Priority: US20040590939P Applic. Date: 2004-07-26; WO2005IL00785 Applic. Date: 2005-07-24

Inventor: TRAININ ZEEV [IL]; LEITNER GABRIEL [IL]; LUBASHEVSKY EUGENIA [IL]; SVARANSKY SOFIA [IL]


Application No.: US20090186923A1  Published: 23/Jul/2009

Title: Compounds Having CRTH2 Antagonist Activity

Applicant/Assignee:

Application No.: 12/356822   Filing Date: 21/Jan/2009

Abstract:Compounds of general formula (I) wherein W is chloro or fluoro

R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl

each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl

p and q are each independently an integer from 1 to 3

and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

Priority: GB20080000874 Applic. Date: 2008-01-18; GB20080020526 Applic. Date: 2008-11-10

Inventor: ARMER RICHARD EDWARD [GB]; PETTIPHER ERIC ROY [GB]; WHITTAKER MARK [GB]; WYNNE GRAHAM MICHAEL [GB]; VILE JULIA [GB]; SCHROER FRANK [GB]


Application No.: US20090186942A1  Published: 23/Jul/2009

Title: NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS

Applicant/Assignee:

Application No.: 12/279516   Filing Date: 13/Feb/2007

Abstract:The invention relates to novel compositions comprising a phenolic compound as well as to the use of these compositions as a medicament, in particular for the manufacture of a nutraceutical or pharmaceutical composition for the treatment, co-treatment or prevention of inflammatory disorders, such as arthritis, asthma, inflammatory bowel diseases, inflammatory diseases of the skin (e.g., psoriasis, eczema, atopic dermatitis, sunburn) and chronic inflammatory disorders, such as atherosclerosis, heart diseases, metabolic syndrome X, cancer, Alzheimer's disease and pre-stages thereof such as mild cognitive impairment. Also, the invention relates to the use of a cosmetic composition comprising a phenolic compound for the cosmetic treatment, co-treatment or prevention of inflammation of the skin, in particular for the cosmetic treatment, co-treatment or prevention of sunburn or of impure skin.

Priority: EP20060003156 Applic. Date: 2006-02-16; WO2007EP01227 Applic. Date: 2007-02-13

Inventor: RAEDERSTORFF DANIEL [FR]; SCHWAGER JOSEPH [CH]; SCHUELER GOEDE [DE]


Application No.: US20090186950A1  Published: 23/Jul/2009

Title: 13,13-Dimethyl-des-C,D Analogs of 1Alpha,25-Dihydroxy-19-Nor-Vitamin D3 Compounds and Topical Composition Dosage Forms and Methods of Treating Skin Conditions Thereof

Applicant/Assignee:

Application No.: 12/357702   Filing Date: 22/Jan/2009

Abstract:13,13-Dimethyl-des-C,D analogs of 1alpha,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (1R,3R)-5-[(E)-(S)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-1,3-diol, (1R,3R)-5-[(Z)-(S)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-1,3-diol, (1R,3R)-5-[(E)-(R)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-1,3-diol, and (1R,3R)-5-[(Z)-(R)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-1,3-diol.

Priority: US20080022696P Applic. Date: 2008-01-22

Inventor: DELUCA HECTOR F [US]; CLAGETT-DAME MARGARET [US]; PLUM LORI A [US]; SICINSKI RAFAL R [PL]; PLONSKA-OCYPA KATARZYNA [PL]; NIEVES NIRCA J [US]; GRZYWACZ PAWEL [US]


Application No.: US20090187060A1  Published: 23/Jul/2009

Title: Method and Formulation for Neutralizing Toxic Chemicals and Materials

Applicant/Assignee: E-Z-EM, INC

Application No.: 12/017749   Filing Date: 22/Jan/2008

Abstract:The present invention is directed to a formulation and associated method for neutralizing one or more toxic chemical and/or materials including toxic industrial chemicals and toxic industrial materials, such as irritants, heavy metals, radioactive metals, acids and acid irritants, pesticides, and various agricultural chemicals, (collectively referred to as toxic chemical, materials, or simply toxins) as well as decontaminating surfaces that have come into contact with these agents. As a result, the formulation of the present invention can be used for neutralizing a broad spectrum of toxic chemicals and materials. In one embodiment, the active ingredient comprises 2, 3, butanedione monoxime (also known as diacetyl monoxime (DAM)), and alkali salts thereof such as potassium 2,3-butanedione monoxime (KBDO). The formulation also typically includes a carrier in which the active ingredient is dispersed. In one embodiment, the carrier comprises polyethylene glycol (PEG)

monomethoxypolyethylene glycol(mPEG)

and combinations and derivatives thereof.

Priority:

Inventor: HENRY TIMOTHY G [US]; PRICE BARBARA B [US]


Application No.: US20090187167A1  Published: 23/Jul/2009

Title: INTEGRATED INTRA-DERMAL DELIVERY, DIAGNOSTIC AND COMMUNICATION SYSTEM

Applicant/Assignee: NEW WORLD PHARMACEUTICALS, LLC

Application No.: 12/337417   Filing Date: 17/Dec/2008

Abstract:In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of "cells" containing therapeutic agent(s) and/or diagnostic agents(s)

an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.

Priority: US20070014184P Applic. Date: 2007-12-17; US20080023972P Applic. Date: 2008-01-28

Inventor: SEXTON FREDERICK A [US]; SUNI IAN IVAR [US]; CETINKAYA CETIN [US]; SCHUCKERS STEPHANIE [US]; SAZONOV EDUARD [US]


Application No.: US20090189090A1  Published: 30/Jul/2009

Title: METHOD OF SELECTING ANTIOXIDANTS FOR USE IN TOPICALLY APPLIED COMPOSITIONS

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 12/357006   Filing Date: 21/Jan/2009

Abstract:Antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. Methods for testing a composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum. Compositions and methods for treating and preventing photodamage to skin.

Priority: US20080114758P Applic. Date: 2008-11-14; US20080023713P Applic. Date: 2008-01-25

Inventor: MEYER THOMAS A [US]; BEASLEY DONATHAN G [US]


Application No.: US20090189307A1  Published: 30/Jul/2009

Title: COMPOSITE STRUCTURES WITH INTEGRAL INTELLIGENT SKIN

Applicant/Assignee: GENERAL ATOMICS

Application No.: 12/419833   Filing Date: 07/Apr/2009

Abstract:Composite structures having an integral intelligent skin are made of one or more plies of a structural base material and an intelligent or smart film by molding one or more plies and the film into an integral unitary body with the intelligent film outermost. The intelligent or smart film contains or bears a functionally active or interactive component such as antennae, electronic sensors, electric and/or electronic circuitry, and/or spectrally tailored coatings. A method of making the composite structure in a very economical manner is disclosed.

Priority: US2006-448284 Applic. Date: 2006-06-07

Inventor: MCGOVERN THOMAS R [US]; HUBBARD RONALD N [US]


Application No.: US20090191156A1  Published: 30/Jul/2009

Title: GM-CSF COSMECEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 12/052670   Filing Date: 20/Mar/2008

Abstract:It has been discovered that granulocyte macrophage colony stimulating factor ("GM-CSF") promotes migration of activated (but not differentiating) keratinocytes to wound sites. It was also discovered that GM-CSF increases the quantity and improves the quality of collagen. This growth factor specifically increases migration of keratinocytes of the "wound" phenotype but does not have significant effects upon differentiated keratinocytes. Examples demonstrate reversal of skin impairment in multiple animal models of diabetic skin imparment when provided in an effective amount over an effective time period. The examples also demonstrate the efficacy of the formulations in cosmetic applications. A preferred formulation is a sustained release formulation that delivers sufficient growth factor to the skin and the underlying tissue thereof to increase the rate of keratinocyte migration, as well as collagen deposition and fibroblast proliferation, in the skin to promote rejuvenation of skin injuries resistant to repair due to underlying disease, such as diabetes, or aging.

Priority: US20070895911P Applic. Date: 2007-03-20

Inventor: BREM HAROLD [US]; TOMIC MARJANA [US]


Application No.: US20090191245A1  Published: 30/Jul/2009

Title: REDUCED-IRRITANT DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND BENZOYL PEROXIDE AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/272061   Filing Date: 17/Nov/2008

Abstract:Topically applicable, reduced-irritant dermatological/cosmetic compositions useful for the prevention/treatment of a variety of keratinization disorders, for example acne vulgaris, contain at least one naphthoic acid compound and an amount of benzoyl peroxide encapsulated in a polymeric system of porous particles for increasing cutaneous penetration of the at least one naphthoic acid compound, are formulated into topically applicable, physiologically acceptable media therefor.

Priority: FR20060004407 Applic. Date: 2006-05-17; WO2007FR51296 Applic. Date: 2007-05-16

Inventor: FREDON LAURENT [FR]; WILLCOX NATHALIE [FR]; SEGURA-ORSONI SANDRINE [FR]


Application No.: US20090191288A1  Published: 30/Jul/2009

Title: Composition to Treat Herpes, Pseudomonas, Staph, Hepatitis and Other Infectious Diseases

Applicant/Assignee:

Application No.: 12/248402   Filing Date: 09/Oct/2008

Abstract:An improved method (process) and medicinal composition is provided to treat herpes, pseudomonas, hepatitis, staph (staphylococci) and other infectious diseases The inexpensive medicinal composition can be self-administered and maintained for a prescribed time. The attractive medicinal composition can comprise a quaternary ammonium salt surfactant, a skin protectant and an alcohol. The quaternary ammonium salt surfactant can comprise benzalkonium halide, preferably benzalkonium chloride. The skin protectant can comprise Allantoin. The alcohol can serve as a pain reliever and can comprise benzyl alcohol. The medicinal composition can also include other compounds, additives, herbal extracts and/or carriers.

Priority: US2005-202986 Applic. Date: 2005-08-12; US2002-084759 Applic. Date: 2002-02-26; US1997-824041 Applic. Date: 1997-03-26; US1996-646988 Applic. Date: 1996-05-08; US1996-600217 Applic. Date: 1996-02-12

Inventor: SQUIRES MERYL J [US]


Application No.: US20090192100A1  Published: 30/Jul/2009

Title: NOVEL USE OF SPIEGELMERS

Applicant/Assignee:

Application No.: 11/913526   Filing Date: 04/May/2006

Abstract:The present invention relates to the use of a L-nucleic acid as intracellularly active agent.

Priority: DE200510020874 Applic. Date: 2005-05-04; WO2006EP04180 Applic. Date: 2006-05-04

Inventor: VATER AXEL [DE]; MAASCH CHRISTIAN [DE]; KLUSSMANN SVEN [DE]; PURSCHKE WERNER [DE]; EULBERG DIRK [DE]; JAROSCH FLORIAN [DE]; BUCHNER KLAUS [DE]


Application No.: US20090192126A1  Published: 30/Jul/2009

Title: Oral Composition Comprising a Polyunsaturated Fatty Acid and Salicylic Acid for Obtaining an Antiinflammatory Effect in Skin

Applicant/Assignee:

Application No.: 12/226164   Filing Date: 05/Apr/2007

Abstract:A composition which is adapted for oral consumption and which is in the form of a substantially homogeneous aqueous emulsion, suspension or dispersion comprising salicylic acid, or a C1 to C6 alkyl ester thereof, and docosahexaenoic acid (DHA) can exhibit an anti-inflammatory effect in skin.

Priority: EP20060252027 Applic. Date: 2006-04-12; EP20070102129 Applic. Date: 2007-02-12; WO2007EP53410 Applic. Date: 2007-04-05

Inventor: CASEY JOHN [GB]; JAMES ALEXANDER GORDON [GB]; JENKINS GAIL [GB]; WAINWRIGHT LINDA JANE [GB]


Application No.: US20090192195A1  Published: 30/Jul/2009

Title: Compounds Having CRTH2 Antagonist Activity

Applicant/Assignee: OXAGEN LIMITED

Application No.: 12/357821   Filing Date: 22/Jan/2009

Abstract:Compounds of general formula (I) wherein W is chloro or fluoro

Z is a group SO2R1

wherein R1 is -C3-C8 cycloalkyl or heterocyclyl optionally substituted with one or more substituents chosen from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl

each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl

p and q are each independently an integer from 1 to 3

and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

Priority: GB20080001131 Applic. Date: 2008-01-22; GB20080001672 Applic. Date: 2008-01-30

Inventor: ARMER RICHARD EDWARD [GB]; MAILLOL CAROLE ELIANE ANDREE [GB]; DORGAN COLIN RICHARD [GB]; WYNNE GRAHAM MICHAEL [GB]; VILE JULIA [GB]


Application No.: US20090192203A1  Published: 30/Jul/2009

Title: COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

Applicant/Assignee: IRM LLC

Application No.: 12/092962   Filing Date: 07/Nov/2006

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US20050734683P Applic. Date: 2005-11-07; WO2006US43342 Applic. Date: 2006-11-07

Inventor: EPPLE ROBERT [US]; COW CHRISTOPHER [US]; AZIMIOARA MIHAI [US]; RUSSO ROSS [US]; XIE YONGPING [US]; WANG XING [US]


Application No.: US20090196836A1  Published: 06/Aug/2009

Title: Multi-Functional, Multi-Phase Skin Care Product

Applicant/Assignee:

Application No.: 12/252638   Filing Date: 16/Oct/2008

Abstract:A skin care product may comprise a non-solid, multi-phase multi-function skin care composition comprising a translucent base phase, a first opaque phase, and a second opaque phase. The three phases form a stable, visually distinct pattern within a container that is at least partially translucent. The first opaque phase may have a lightness of greater than about 80 and a chroma of less than about 5. The second opaque phase may have a hue from about 35 to about 70. The translucent base phase may include a first chronic skin care active

the first opaque phase may include a skin conditioning agent

and the second opaque may comprise one or more opacifying particulate materials. The skin care product may further comprise a plurality of informational indicium. An array of skin care products comprising a first skin care product and a second skin care product is also disclosed.

Priority: US20070000417P Applic. Date: 2007-10-25

Inventor: TANNER PAUL ROBERT [US]; ELSBROCK ROBERT JOHN [US]


Application No.: US20090196839A1  Published: 06/Aug/2009

Title: DISPERSION OF POLYMER PARTICLES, COMPOSITION COMPRISING SAME AND COSMETIC TREATMENT METHOD

Applicant/Assignee:

Application No.: 12/362862   Filing Date: 30/Jan/2009

Abstract:Dispersions of particles of surface-stabilized polymer, in a nonaqueous medium, in which the polymer contains 5% to 50% by weight of ethylenic monomers which can contain a PEG (polyethylene glycol) part. Dispersions can be used in cosmetic or pharmaceutical compositions such as lipstick or hair. The composition can be used to treat keratin materials.

Priority: FR20080050636 Applic. Date: 2008-02-01; US20080064022P Applic. Date: 2008-02-11

Inventor: FARCET CELINE [FR]


Application No.: US20090196841A1  Published: 06/Aug/2009

Title: Color Cosmetics Containing Isoalkane Mixture and Effect Pigments

Applicant/Assignee: BASF CORPORATION

Application No.: 12/026079   Filing Date: 05/Feb/2008

Abstract:The invention provides compositions for color cosmetic formulations comprising a specially formulated isoalkane mixture and effect pigments, and optionally, one or more cosmetically acceptable auxiliary agents, and methods for making the color cosmetics formulations.

Priority:

Inventor: SONG LEILA [US]; AUCAR BETTY [US]; MYTIL TATYANA [US]


Application No.: US20090196876A1  Published: 06/Aug/2009

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC

Application No.: 11/577547   Filing Date: 18/Oct/2005

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20040623789P Applic. Date: 2004-10-29; WO2005US37291 Applic. Date: 2005-10-18

Inventor: DE SAUVAGE FRED [US]; FRENCH DOROTHY [US]; GONZALEZ LINO [US]; PRAETOR ASJA [SG]; YE WEILAN [US]; COMBS KATHERIN E [US]; DING ZHIYONG [US]; BYERS HORNER ALLISON ANNE [US]; MASSEY ERIN MARIE [US]; MONTGOMERY CHARLES [US]; MINZE LAURIE JEANETTE [US]; RANGEL CAROLINA [US]; WILLIS SEVAUX TRACY ELLEN [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; STALA JOY ANNE [US]; VOGEL PETER [US]


Application No.: US20090196893A1  Published: 06/Aug/2009

Title: Aqueous Cosmetic Composition, Especially for Use as Moisturizing Lotions

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/227249   Filing Date: 15/May/2007

Abstract:The invention relates to the use of an aqueous composition comprising at least one surface-active agent in the form of bilayers and exhibiting a structure of sponge phase type as cosmetic composition or for the preparation of a cosmetic composition. It also relates to aqueous compositions, in particular lotions, in the sponge phase form including at least one cosmetic active agent or one cosmetic additive. It also relates to a method for the cosmetic care of the skin or superficial body growths, in particular for the purpose of moisturizing them, and/or to a method intended to give fragrance to the skin or superficial body growths.

Priority: FR20060051742 Applic. Date: 2006-05-15; WO2007FR51278 Applic. Date: 2007-05-15

Inventor: TRANCHANT JEAN-FRANCOIS [FR]; POUGET THIERRY [FR]; VERDIER ELODIE [FR]


Application No.: US20090196895A1  Published: 06/Aug/2009

Title: COSMETIC PREPARATION COMPRISING AN ANTI-AGING SKIN CARE COMPLEX

Applicant/Assignee:

Application No.: 12/307180   Filing Date: 28/Jun/2007

Abstract:The invention relates to a cosmetic preparation which includes a skin care complex having an anti-ageing effect. The complex consists of liposomes comprising a mixture of cosmetic oil, extract of Plukenetia volubilis seeds, extract of Cynara scolymus leaves and hydrogenated retinol. The liposomes are homogeneously dispersed in a gel network consisting of water and a gel-forming agent.

Priority: DE200610031762 Applic. Date: 2006-07-05; WO2007EP56494 Applic. Date: 2007-06-28

Inventor: GOLZ-BERNER KARIN [DE]; ZASTROW LEONHARD [DE]


Application No.: US20090196912A1  Published: 06/Aug/2009

Title: Pyridinylamines

Applicant/Assignee: GPC BOTECH AG

Application No.: 11/659013   Filing Date: 01/Aug/2005

Abstract:Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases, including opportunistic infections, prion diseases immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as pharmaceutical compositions containing at least one pyridinylamine and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the pyridinylamines are disclosed.

Priority: EP20040018131 Applic. Date: 2004-07-30; US20040599307P Applic. Date: 2004-08-06; WO2005EP08321 Applic. Date: 2005-08-01

Inventor: EICKHOFF JAN ELKE [DE]; HAFENBRADL DORIS [DE]; SCHWAB WILFRIED [DE]; COTTON MATTHEW [GM]; KIEBL BERT MATTHIAS [DE]; ZECH BIRGIT [DE]; MULLER STEFAN [DE]; HARRIS JOHN [GB]; SAVIC VLADIMIR [SA]; MACRITCHIE JACKIE [GB]


Application No.: US20090196939A1  Published: 06/Aug/2009

Title: ANTIMICROBIAL COMPOSITION

Applicant/Assignee: ECOLAB INC

Application No.: 12/368070   Filing Date: 09/Feb/2009

Abstract:A method for antimicrobial treatment (e.g. antimicrobial treatment of food packaging and equipment) comprising applying to microbes a composition containing a diluting solvent (e.g., water), an antimicrobially-active solvent having a density different from the density of the diluting solvent, and an optional cosolvent, surfactant, or additional antimicrobial agent, wherein the amount of antimicrobially-active solvent or additional antimicrobial agent is sufficiently high and the amount of cosolvent or surfactant is sufficiently low so that the composition will provide greater than a 1-log order reduction in the population of bacteria or spores of Bacillus cereus within 10 seconds at 60 DEG C. Preferred methods of the invention employ compositions containing an additional antimicrobial agent such as peroxyacetic acid. Compositions for use in the method can be prepared as concentrates, and used full strength or in diluted form.

Priority: US2005-318062 Applic. Date: 2005-12-22; US2003-413635 Applic. Date: 2003-04-14; US2001-794790 Applic. Date: 2001-02-27; US2000-560170 Applic. Date: 2000-04-28; US2000-641775 Applic. Date: 2000-08-18

Inventor: HEI ROBERT D P [US]; WEI GUANG-JONG J [US]; HALSRUD DAVID A [US]; SMITH KIM R [US]; PODTBURG TERESA C [US]


Application No.: US20090197256A1  Published: 06/Aug/2009

Title: Use of a fibroblast growth factor-binding protein for the treatment and diagnosis of diabetic wound healing problems

Applicant/Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V

Application No.: 12/012676   Filing Date: 05/Feb/2008

Abstract:The present invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides, and functional variants of these polypeptides, respectively, or of nucleic acids encoding these polypeptides or variants, or of functional variants of these nucleic acids, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for treating, diagnosing and/or preventing wound healing disturbances which are characterized by a reduced quantity of FGF-BP, in particular diabetes-associated wounds, and also to the use of at least one FGF-BP polypeptide as depicted in SEQ ID No. 1 and SEQ ID No. 3 and/or of at least one FGF-BP-encoding nucleic acid as depicted in SEQ ID No. 2 and SEQ ID No. 4 and/or of antibodies or antibody fragments which are directed against an FGF-BP polypeptide which can be used in accordance with the invention, or functional variants thereof, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for identifying pharmacologically active substances which increase the activity of expression of FGF-BP.

Priority: EP20020004299 Applic. Date: 2002-02-28; US2004-927322 Applic. Date: 2004-08-26; WO2003EP02122 Applic. Date: 2003-02-28; US20020362497P Applic. Date: 2002-03-06

Inventor: GOPPELT ANDREAS [AT]; BITTNER MICHAELA [AT]


Application No.: US20090197819A1  Published: 06/Aug/2009

Title: Compositions for improving and repairing skin

Applicant/Assignee:

Application No.: 11/726020   Filing Date: 20/Mar/2007

Abstract:Compositions for improving the condition of the skin or for repairing damaged skin are disclosed. The compositions contain D-ribose as the active ingredient plus a penetrant to deliver D-ribose to the basal cells and dermis of the skin. Compositions further containing emollients and emulsifiers are disclosed.

Priority:

Inventor: JOHNSON CLARENCE ALBERT [US]; ST CYR JOHN A [US]


Application No.: US20090197927A1  Published: 06/Aug/2009

Title: JASMONATE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee: SEPAL PHARMA LTD

Application No.: 12/096111   Filing Date: 07/Dec/2006

Abstract:The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.

Priority: US20050742875P Applic. Date: 2005-12-07; US20060772582P Applic. Date: 2006-02-13; US20060830666P Applic. Date: 2006-07-14; WO2006IL01409 Applic. Date: 2006-12-07

Inventor: HERZBERG MAX [IL]; HAREL ADRIAN [IL]; MANG CHRISTIAN [DE]


Application No.: US20090197938A1  Published: 06/Aug/2009

Title: Polyphenol Type Compounds, Compositions Containing Same and Use Thereof for Preventing or Treating Diseases Involving Abnormal Cell Proliferation

Applicant/Assignee: FLUOFARMA UNIVERSITE DE BORDEAUX 1

Application No.: 11/922516   Filing Date: 23/Jun/2006

Abstract:The invention concerns compounds of formula (I), wherein -XmR1 and YnR2, identical or different are present, or one of the XmR1 or YnR2 is absent and YaR2, identical or different, is present, and in that case the bond between C1 and C2 is a double bond, XmR1 and YnR2 together represent a group A and in that case the bond between C1 and A is a double bond, or their pharmaceutically acceptable salts as medicine.

Priority: FR20050007051 Applic. Date: 2005-07-01; WO2006FR01455 Applic. Date: 2006-06-23

Inventor: DEPIERRE GAELLE [FR]; QUIDEAU STEPHANE [FR]; JOURDES MICHAEL [FR]; PARDON PATRICK [FR]; POURQUIER PHILIPPE [FR]


Application No.: US20090197939A1  Published: 06/Aug/2009

Title: METHODS OF TREATING SKIN WITH AROMATIC SKIN-ACTIVE INGREDIENTS

Applicant/Assignee: MARY KAY INC

Application No.: 12/105957   Filing Date: 18/Apr/2008

Abstract:A method for treating skin, reducing oxidative damage to a skin cell, reducing lipoxygenase (LO) activity in a skin cell, reducing cyclooxygenase (COX) activity in a skin cell, reducing tumor necrosis factor alpha (TNF-alpha) in a skin cell, or reduction matrix metalloproteinase enzyme activity in a skin cell comprising contacting skin or a skin cell with an aromatic skin-active ingredient.

Priority: US20080025631P Applic. Date: 2008-02-01

Inventor: WALKE BOB [US]; GOMEZ CRISTI [US]; FLORENCE TIFFANY C [US]; HINES MICHELLE D [US]


Application No.: US20090202430A1  Published: 13/Aug/2009

Title: COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING POLYSACCHARIDE SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS

Applicant/Assignee: BIO SYNTECH CANADA INC

Application No.: 12/423156   Filing Date: 14/Apr/2009

Abstract:The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.

Priority: US2005-521524 Applic. Date: 2005-09-20; WO2003CA01069 Applic. Date: 2003-07-16; US20020395991P Applic. Date: 2002-07-16

Inventor: HOEMANN CAROLINE [CA]; CHENITE ABDELLATIF [CA]; BUSCHMANN MICHAEL [CA]; SERREQI ALESSIO [CA]; SUN JUN [CA]


Application No.: US20090202459A1  Published: 13/Aug/2009

Title: PHOTOPROTECTIVE COMPOSITIONS WITH GLYCOL AND STYRENE/ACRYLATE COPOLYMER

Applicant/Assignee: PLAYTEX PRODUCTS, INC

Application No.: 12/367579   Filing Date: 09/Feb/2009

Abstract:A photoprotective composition includes one or more photoactive agents (such as a UV filter compound), one or more optimizing agents, and a copolymer booster. Such a composition provides an unexpected synergistic combination of the one or more optimizing agents and the copolymer booster for increasing at least one of SPF, UVA/UVB ratio, critical wavelength, photostability of UVA absorber and PFA, and any combinations thereof, of the composition.

Priority: US20080027672P Applic. Date: 2008-02-11

Inventor: SPAULDING LAURA A [US]


Application No.: US20090202582A1  Published: 13/Aug/2009

Title: Water-Disposable or Water-Soluble Polymer Film as a Vehicle for Dermatologic and Cosmetic Active Agents

Applicant/Assignee: MIBELLE AG

Application No.: 12/367042   Filing Date: 06/Feb/2009

Abstract:Described are water-dispersible or water-soluble polymer films incorporating at least one cosmetic or dermatologic active agent and a method for the production thereof. The active agents involved are particularly anti-cellulite agents, moisturizers, anti-wrinkle agents and skin smoothing agents.

Priority: CH20080000164 Applic. Date: 2008-02-07

Inventor: IRRGANG BERNHARD [CH]; MACQUARRIE REGINALD [CA]


Application No.: US20090202654A1  Published: 13/Aug/2009

Title: Skin Care Compositions and Treatments

Applicant/Assignee: ORGANOGENESIS, INC

Application No.: 12/097132   Filing Date: 14/Dec/2006

Abstract:The invention is directed compositions containing growth agents synthesized from cultured cells from skin. Skin cells such as keratinocytes and dermal fibroblasts are cultured in vitro in cell medium and in the course of culture the cultured cells synthesize and secrete agents into the cell medium. The medium containing agents are collected and incorporated into pharmaceutical or cosmetic preparations to treat an individual. The preparation is applied and has a rejuvenating effect on the cells and tissue.

Priority: US20050750447P Applic. Date: 2005-12-14; WO2006US62090 Applic. Date: 2006-12-14

Inventor: NIXON ANDREW J [US]


Application No.: US20090202666A1  Published: 13/Aug/2009

Title: COSMETIC USE OF A CASSUMUNARIN, AN ARYLBUTENOID, AND/OR A BOTANICAL EXTRACT CONTAINING THEM

Applicant/Assignee: CHANEL PARFUMS BEAUTE

Application No.: 12/304660   Filing Date: 31/May/2007

Abstract:The present invention relates to a cosmetic skin care method to prevent and/or treat at least one sign of skin ageing, comprising the topical application to the skin of a composition comprising at least one active ingredient selected from cassumunarin and/or an arylbutenoid and/or a botanical extract containing them, such as an extract from Zingiber cassumunar Roxb. It also pertains to an extract from Zingiber cassumunar Roxb, which is obtainable by extracting rhizomes thereof with at least one apolar solvent having a polarity index of less than 1, optionally mixed with at least one polar solvent having a polarity index of more than 3.5.

Priority: EP20060290953 Applic. Date: 2006-06-12; US20060831668P Applic. Date: 2006-07-19; WO2007EP55294 Applic. Date: 2007-05-31

Inventor: HOLDERITH SERGE [FR]; LASSERRE CHRISTELLE MARIE SUZANNE [US]; MAESTRO YANNICK GERARD [FR]


Application No.: US20090203586A1  Published: 13/Aug/2009

Title: METHOD FOR AMELIORATING AN INFLAMMATORY SKIN CONDITION

Applicant/Assignee: SYNGENTA LIMITED

Application No.: 11/570148   Filing Date: 10/Jun/2005

Abstract:The present invention relates to the use of thioredoxin in the manufacture of a medicament suitable for application to a skin surface for ameliorating an inflammatory skin condition. The present invention further relates to a method of ameliorating an inflammatory skin condition comprising applying to a skin surface an effective amount of a composition comprising thioredoxin. The invention further relates to a pharmaceutical composition suitable for ameliorating an inflammatory skin condition comprising from 0.0001 to 0.5 w/v thioredoxin.

Priority: GB20040013114 Applic. Date: 2004-06-11; GB20050004426 Applic. Date: 2005-03-03; WO2005GB02300 Applic. Date: 2005-06-10

Inventor: DEARMAN REBECCA JANE [GB]; CUMBERBATCH MARIE [GB]; KIMBER IAN [GB]; DEL VAL GREGORIO [GB]


Application No.: US20090203642A1  Published: 13/Aug/2009

Title: SPRAY-DRIED CHITIN NANOFIBRILS, METHOD FOR PRODUCTION AND USES THEREOF

Applicant/Assignee: MAVI SUD S.R.L

Application No.: 12/094912   Filing Date: 23/Nov/2006

Abstract:The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased dispersibility in aqueous media. The invention further relates to uses of nanofibrils in pastes and aqueous gels useful for topical on-skin application, to the manufacturing of materials of biomedical interest, as well as to the deposition of chitin nanofibrils on coating surfaces or the incorporation of the same inside of items like, e.g., fibers and fabrics of any Origin, natural as well as synthetic or mixed ones.

Priority: IT2005RM00585 Applic. Date: 2005-11-23; WO2006IB54403 Applic. Date: 2006-11-23

Inventor: MORGANTI PIERFRANCESCO [IT]; MUZZARELLI CORRADO [IT]


Application No.: US20090203658A1  Published: 13/Aug/2009

Title: NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 12/404886   Filing Date: 16/Mar/2009

Abstract:Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

Priority: US2008-008259 Applic. Date: 2008-01-08; US20070879165P Applic. Date: 2007-01-08

Inventor: MARX CHRISTINE E [US]; ROSE JED E [US]


Application No.: US20090203662A1  Published: 13/Aug/2009

Title: NOVEL DERIVATIVES OF CHOLEST-4-EN-3-ONE OXIME, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PREPARATION METHOD

Applicant/Assignee: TROPHOS

Application No.: 12/158640   Filing Date: 15/Dec/2006

Abstract:The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a -N-OH group and R represents a group selected from or one of its esters and/or of its addition salts with pharmaceutically acceptable acids, particularly as a cytoprotective drug, preferentially a cardioprotective and/or neuroprotective drug, the compounds of formula I wherein R is R2, R3, R4, R5 or R6 as novel compounds as well as their preparation method and use.

Priority: FR20050012947 Applic. Date: 2005-12-20; WO2006FR02740 Applic. Date: 2006-12-15

Inventor: DROUOT CYRILLE [FR]; MAUX DELPHINE [FR]


Application No.: US20090203690A1  Published: 13/Aug/2009

Title: 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/327991   Filing Date: 04/Dec/2008

Abstract:The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

Priority: WO2008US62727 Applic. Date: 2008-05-06; US2008-132993 Applic. Date: 2008-06-04; US20070933960P Applic. Date: 2007-06-08

Inventor: AKRITOPOULOU-ZANZE IRINI [US]; WAKEFIELD BRIAN D [US]; MACK HELMUT [DE]; TURNER SEAN C [DE]; GASIECKI ALAN F [US]; GRACIAS VIJAYA J [US]; SARRIS KATHY A [US]; KALVIN DOUGLAS M [US]; MICHMERHUIZEN MELISSA J [US]; SHUAI QI [US]; PATEL JYOTI R [US]; BAKKER MARGARETHA H M [DE]; TEUSCH NICOLE [DE]; JOHNSON ERIC F [US]; KOVAR PETER J [US]; DJURIC STEVAN W [US]; LONG ANDREW J [US]; VASUDEVAN ANIL [US]; GEORGE DAWN [US]; WANG LU [US]; LI BIQIN [US]; MOORE N ST JOHN [US]; HOBSON ADRIAN D [US]; WOODS KEITH W [US]; MIYASHIRO JULIE M [US]; SWANN JR STEVEN L [US]; PENNING THOMAS D [US]


Application No.: US20090203739A1  Published: 13/Aug/2009

Title: Anti-Inflammatory Agents

Applicant/Assignee:

Application No.: 11/922283   Filing Date: 14/Jun/2006

Abstract:The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder

wherein z X is 1, 2 or 4

X is -CO-Yk-(R1)n or SO2-Yk-(R1)n

k is 0 or 1

Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group)

or is a cycloalkenyl or polycycloalkenyl group

each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms)

or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical

and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R1 group is bonded directly to the carbonyl or sulfonyl group)

provided that simultaneously X cannot be an undec-10-en-1-oyl group and z be equal to 1 or 2

or alternatively R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.

Priority: GB20050012238 Applic. Date: 2005-06-15; WO2006GB02218 Applic. Date: 2006-06-14

Inventor: GRAINGER DAVID J [GB]; FOX DAVID JOHN [GB]


Application No.: US20090203745A1  Published: 13/Aug/2009

Title: HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF

Applicant/Assignee: JERINI AG

Application No.: 12/300530   Filing Date: 14/May/2007

Abstract:The present invention relates to compounds of formula (I) wherein: A is a radical selected from the group comprising aromatic heterocyclic 5-membered ring systems

Ar is a radical selected from the group comprising optionally substituted 5- and 6-membered aromatic ring systems, whereby the ring system contains 0, 1, 2 or 3 heteroatoms selected from the group comprising N, O and S

Z is a linker and Psi is a radical of formula (II) and their use for the inhibition of integrin.

Priority: EP20060009872 Applic. Date: 2006-05-12; WO2007EP04283 Applic. Date: 2007-05-14

Inventor: ZISCHINSKY GUNTHER [DE]; STRAGIES ROLAND [DE]; OSTERKAMP FRANK [DE]; SCHARN DIRK [DE]; HUMMEL GERD [DE]; KALKHOF HOLGER [DE]; ZAHN GRIT [DE]; VOSSMEYER DOERTE [DE]; CHRISTNER-ALBRECHT CLAUDIA [DE]; REINEKE ULRICH [DE]


Application No.: US20090208499A1  Published: 20/Aug/2009

Title: N-(Phosphonoalkyl)-Amino Acids, Derivatives Thereof and Compositions and Methods of Use

Applicant/Assignee:

Application No.: 12/428906   Filing Date: 23/Apr/2009

Abstract:The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine.

Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.

Priority: US2008-194203 Applic. Date: 2008-08-19; US2007-621287 Applic. Date: 2007-01-09; US20060757614P Applic. Date: 2006-01-10

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]


Application No.: US20090208541A1  Published: 20/Aug/2009

Title: Oil-In-Water Nanoemulsion, A Cosmetic Composition And A Cosmetic Product Comprising It, A Process For Preparing Said Nanoemulsion

Applicant/Assignee:

Application No.: 11/577931   Filing Date: 25/Aug/2005

Abstract:The present invention relates to an oil-in-water emulsion for cosmetic use, wherein the oil particles have an average diameter ranging from 50 to 200 nm (nanometers). The nanoemulsion comprises an emulsifying system having components such as ceteareth-20, ceteareth-12, glyceryl stearate, cetearyl alcohol and cetyl palmitate. This composition imparts to the nanoemulsion an opaque coloration, besides providing to the skin inherent properties of the nanoemulsion such as better absorption of the components by the skin, imparting softness, smoothness and moisturizing for 24 hours, and may be added to products indicated for hair care. The composition of the nanoemulsion without addition of preservatives imparts a bactericidal action. The nanoemulsion is preferably used for cosmetic applications 5 for the body, face and hair in the form of milk, lotions and gels. The present invention further relates to the cosmetic compositions and cosmetic products that comprise the nanoemulsions above, as well as to a process for preparing them.

Priority: BR2004PI04595 Applic. Date: 2004-10-26; WO2005BR00222 Applic. Date: 2005-10-25

Inventor: GESZTESI JEAN-LUC [BR]; SANTOS LEANDRA MORAES [BR]; HENNIES PAULO DE TARSO [BR]; MACIAN KARLA ARAUJO [BR]


Application No.: US20090208938A1  Published: 20/Aug/2009

Title: Use of the MCM8 Gene for the Preparation of a Pharmaceutical Composition

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Application No.: 11/884053   Filing Date: 09/Feb/2006

Abstract:The use of the human or animal MCM8 gene coding for a DNA helicase, or parts of the gene, or transcripts thereof, or antisense nucleic acids able to hybridize with part of the transcripts, or silencing RNA derived from parts of the transcripts and able to repress the MCM8 gene, or proteins or peptidic fragments translated from the transcripts, or antibodies directed against the proteins or peptidic fragments for the preparation of a pharmaceutical composition for the treatment of a human or animal pathology linked to a dysfunction of the expression of the MCM8 gene, or of human or animal cancers.

Priority: US20050651510P Applic. Date: 2005-02-10; WO2006EP01158 Applic. Date: 2006-02-09

Inventor: MECHALI MARCHEL [FR]; MAIORANO DOMENICO [FR]


Application No.: US20090209031A1  Published: 20/Aug/2009

Title: MEDICAL DEVICE PACKAGE

Applicant/Assignee: TYCO HEALTHCARE GROUP LP

Application No.: 12/431837   Filing Date: 29/Apr/2009

Abstract:A package for a medical device, the package capable of sustaining viable cells, wherein the package includes a first container, which is configured to receive a medical device and to sustain at least one viable cell, and a fluid port in communication with the first container for allowing sterile passage of an agent to the medical device and for maintaining cell viability.

Priority: US2007-954426 Applic. Date: 2007-12-12; US2006-340912 Applic. Date: 2006-01-26; US20080049504P Applic. Date: 2008-05-01

Inventor: STOPEK JOSHUA B [US]


Application No.: US20090209539A1  Published: 20/Aug/2009

Title: Pyrimidine derivatives as alk-5 Inhibitors

Applicant/Assignee:

Application No.: 12/308232   Filing Date: 12/Jul/2007

Abstract:Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Priority: EP20060117227 Applic. Date: 2006-07-14; EP20060119564 Applic. Date: 2006-08-25; WO2007EP06192 Applic. Date: 2007-07-12

Inventor: LEBLANC CATHERINE [GB]; PIPET MAUDE NADINE PIERRETTE [GB]; FAIRHURST ROBIN ALEC [GB]; ADCOCK CLAIRE [GB]; PULZ ROBERT ALEXANDER [CH]; SHAW DUNCAN [GB]; STIEFL NIKOLAUS JOHANNES [DE]


Application No.: US20090209559A1  Published: 20/Aug/2009

Title: PHARMACEUTICAL COMPOUNDS

Applicant/Assignee: F. HOFFMANN-LA ROCHE AG

Application No.: 12/299600   Filing Date: 04/May/2007

Abstract:Fused pyrimidines of formula (I): wherein A, n, R1, R2, and R3 have any of the values defined herein and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.

Priority: GB20060008820 Applic. Date: 2006-05-04; WO2007GB01644 Applic. Date: 2007-05-04

Inventor: CHUCKOWREE IRINA S [GB]; FOLKES ADRIAN J [GB]; GOLDSMITH PAUL [GB]; HANCOX TIMOTHY C [GB]; SHUTTLEWORTH STEPHEN J [GB]


Application No.: US20090209614A1  Published: 20/Aug/2009

Title: GLUTAMINE-CONTAINING COMPOSITIONS AND A METHOD FOR INCREASING BLOOD FLOW USING SAME

Applicant/Assignee: AJINOMOTO CO., INC

Application No.: 12/414037   Filing Date: 30/Mar/2009

Abstract:The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg body weight. By administering the composition to a subject in need thereof, the blood flow in the capillary vessels can be efficiently increased, while inhibiting any side effects such as low blood pressure. The present invention also provides food or feed containing the composition for increasing blood flow.

Priority: JP20060266544 Applic. Date: 2006-09-29; WO2007JP68988 Applic. Date: 2007-09-28

Inventor: OHTA FUMIO [JP]; TAKAGI TOMO [JP]; SATO HIROYUKI [JP]


Application No.: US20090209623A1  Published: 20/Aug/2009

Title: Anti-sense nucleic acid derived from organism

Applicant/Assignee:

Application No.: 11/989301   Filing Date: 24/Jul/2006

Abstract:Disclosed are: a method for producing an anti-sense nucleic acid which has a wide variation in nucleotide sequences and excellent anti-sense properties at a low cost in a simple manner and in a large scale

and a cosmetic composition or pharmaceutical composition comprising the anti-sense nucleic acid. A method is discovered which can produce a low molecular weight nucleic acid having anti-sense properties from a nucleic acid starting material derived from an organism at a high yield by using a probe nucleic acid having at least a part of the nucleotide sequence of a target gene. An anti-sense nucleic acid produced by using a nucleic acid derived from an organism as a starting material

and a method for producing the anti-sense nucleic acid.

Priority: JP20050214041 Applic. Date: 2005-07-25; JP20060148621 Applic. Date: 2006-05-29; WO2006JP314597 Applic. Date: 2006-07-24

Inventor: TOMONO JON [JP]; MORIKAWA SOUICHI [JP]; NAKAI TAKAHISA [JP]


Application No.: US20090209958A1  Published: 20/Aug/2009

Title: ELECTROSURGICAL SYSTEM AND METHOD FOR TREATING CHRONIC WOUND TISSUE

Applicant/Assignee: ARTHROCARE CORPORATION

Application No.: 12/430181   Filing Date: 27/Apr/2009

Abstract:An electrosurgical method for treating chronic wound tissue, comprising: positioning an active electrode in close proximity to the chronic wound, the active electrode being disposed on a distal end of an electrosurgical shaft

applying a high-frequency voltage potential difference across the active electrode and a return electrode sufficient to develop a high electric field intensity associated with a vapor layer proximate the active electrode and in close proximity to the wound tissue

and stimulating an expression of at least one healing mediator.

Priority: US2006-327089 Applic. Date: 2006-01-06

Inventor: DAVISON TERRY S [US]; WARNE BRIAN [US]; KWENDE MARTIN [US]


Application No.: US20090214430A1  Published: 27/Aug/2009

Title: POLYPEPTIDE SPECIFICALLY BOUND TO PHOSPHATIDYLSERINE AND THE USE THEREOF

Applicant/Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Application No.: 12/391857   Filing Date: 24/Feb/2009

Abstract:The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

Priority: KR20080016944 Applic. Date: 2008-02-25

Inventor: LEE BYUNG-HEON [KR]; KIM IN-SAN [KR]; NARENDRA THAPA [US]


Application No.: US20090214431A1  Published: 27/Aug/2009

Title: IDENTIFICATION OF ERGOTHIONEINE TRANSPORTER AND THERAPEUTIC USES THEREOF

Applicant/Assignee: UNIVERSITAET ZU KOLN

Application No.: 11/569451   Filing Date: 24/May/2005

Abstract:The transporter that translocates ergothioneine has been identified. Described are methods for identifying and obtaining compounds capable of modulating ergothioneine transport as well as the use of such compounds for the treatment of diseases ergothioneine may be involved in such as autoimmune diseases, in particular rheumatoid arthritis, as well as other diseases arising from cell damage caused by radiation, radicals and relative oxidant species. Furthermore, diagnostic means and methods for determining the presence or susceptibility to such a disease are provided.

Priority: EP20040012250 Applic. Date: 2004-05-24; WO2005EP05613 Applic. Date: 2005-05-24

Inventor: GRUENDEMANN DIRK [DE]; SCHOEMIG EDGAR [DE]


Application No.: US20090214438A1  Published: 27/Aug/2009

Title: METHODS AND COMPOSITIONS FOR THE PREPARATION AND USE OF TOXIN CONJUGATES

Applicant/Assignee: INSTITUT CURIE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

Application No.: 12/338817   Filing Date: 18/Dec/2008

Abstract:The present invention relates to methods for the preparation of toxin conjugates that are useful in vaccination and other therapies and diagnostics. In particular, methods are provided that involve a [3+2] cycloaddition between a first reactive unsaturated group on a toxin moiety and a second reactive unsaturated group on a bioactive moiety. Also provided are conjugates that are formed through this conjugation method, pharmaceutical compositions comprising these conjugates, and methods of using these pharmaceutical compositions for the treatment or diagnostic of antigen-related conditions, including tumors and infections.

Priority: US20070014504P Applic. Date: 2007-12-18

Inventor: JOHANNES LUDGER [FR]; GIOVANI BALDISSERA [FR]; AZOULAY MICHEL [FR]; FLORENT JEAN-CLAUDE [FR]


Application No.: US20090214444A1  Published: 27/Aug/2009

Title: POLY AROMATIC SODIUM CHANNEL BLOCKERS

Applicant/Assignee: PARION SCIENCES, INC

Application No.: 12/393252   Filing Date: 26/Feb/2009

Abstract:Polyaromatic sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

Priority: US20080031466P Applic. Date: 2008-02-26

Inventor: JOHNSON MICHAEL ROSS [US]


Application No.: US20090214447A1  Published: 27/Aug/2009

Title: Preparation of cationic nanoparticles and personal care compositions comprising said nanoparticles

Applicant/Assignee:

Application No.: 12/378567   Filing Date: 17/Feb/2009

Abstract:The present invention is directed to cationic nanoparticles, methods to make them, and the use of compositions containing said nanoparticles in personal care compositions or formulations. The nanoparticles are useful in personal care applications and impart antimicrobial properties to home and personal care products containing them. These cationic nanoparticles also contribute useful conditioning properties to hair-care and skin-care products.

Priority: US20080066599P Applic. Date: 2008-02-21

Inventor: JENNINGS JOHN [IE]; HAGLIN DIETMAR [DE]; MAO JIANWEN [US]; MUHLEBACH ANDREAS [CH]


Application No.: US20090214474A1  Published: 27/Aug/2009

Title: Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development

Applicant/Assignee:

Application No.: 12/387239   Filing Date: 30/Apr/2009

Abstract:The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism.

Priority: US2006-591398 Applic. Date: 2006-11-01; US2007-001869 Applic. Date: 2007-12-13

Inventor: JENNINGS BARBARA BROOKE [US]


Application No.: US20090214504A1  Published: 27/Aug/2009

Title: Methods and Compositions for Topical Treatment of Medical Conditions Including Wounds and Inflammation

Applicant/Assignee: BIOCHEMICS, INC

Application No.: 12/358078   Filing Date: 22/Jan/2009

Abstract:A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.

Priority: US20080022708P Applic. Date: 2008-01-22

Inventor: CARTER STEPHEN G [US]; ZHU ZHEN [US]; PATEL KANU [US]; KOZWICH DIANE L [US]


Application No.: US20090214548A1  Published: 27/Aug/2009

Title: TGR3-Like Protein Receptor

Applicant/Assignee: ARES TRADING S.A

Application No.: 11/721291   Filing Date: 08/Dec/2005

Abstract:There are provided proteins containing a domain corresponding to the C-terminal half of a ZP domain similar to that identified in TGF-beta Receptor III and the use of the proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of diseases. In particular, the present invention relates to the use of the disclosed proteins for modulating the activity of proteins belonging to the TGF-beta superfamily.

Priority: GB20040026960 Applic. Date: 2004-12-08; WO2005GB04728 Applic. Date: 2005-12-08

Inventor: MICHALOVICH DAVID [GB]; MITTER RICHARD JAMES [GB]; FAGAN RICHARD JOSEPH [GB]; POWER CHRISTINE [FR]


Application No.: US20090214572A1  Published: 27/Aug/2009

Title: Methods and compositions for the treatment and diagnosis of endothelial cell disorders and angiogenic disorders

Applicant/Assignee: BETH ISRAEL DEACONESS MEDICAL CENTER CHILDREN'S HOSPITAL BOSTON

Application No.: 11/990803   Filing Date: 18/Aug/2006

Abstract:The invention features methods and compositions for treating and preventing angiogenic disorders and endothelial cells disorders using HspA12B antagonist and HspA12B agonist compounds, respectively.

Priority: US20050711579P Applic. Date: 2005-08-26; WO2006US32497 Applic. Date: 2006-08-18

Inventor: SUKHATME VIKAS P [US]; ZON LEONARD I [US]; GALLOWAY JENNA [US]


Application No.: US20090214607A1  Published: 27/Aug/2009

Title: Topical use of teprenone

Applicant/Assignee: SEDERMA

Application No.: 11/920322   Filing Date: 12/May/2006

Abstract:Topical use of teprenone in a cosmetic or dermopharmaceutical composition as an active preventing and/or limiting the skin cells sénescence and/or protecting the general state of the skin.

Priority: FR20050004869 Applic. Date: 2005-05-13; WO2006IB51497 Applic. Date: 2006-05-12

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]


Application No.: US20090214628A1  Published: 27/Aug/2009

Title: METHODS AND COMPOSITIONS FOR TREATMENT OF SKIN

Applicant/Assignee:

Application No.: 11/912839   Filing Date: 04/Aug/2006

Abstract:The present invention relates to compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or determatologic skin conditions. The invention relates to compositions for treating and ameliorating skin conditions including acne, rosacea and wrinkling caused by photodamage or conditions related to aging, hormonal imbalances, hyper-pigmentation, melasma, keratosis or the like. The invention can also be used to treat conditions of the scalp such as dandruff. The present invention also relates to compositions that can be used to remove biofilms from contact lenses. More particularly, this invention relates to a composition comprising (a) one or more metasilicate

(b) one or more carbonate

(c) one or more glyconate

and (d) one or more sulfate. The composition may also contain (e) salts, e.g., sea salts and other additives or active agents.

Priority: WO2005IB03665 Applic. Date: 2005-09-27; US20040612919P Applic. Date: 2004-09-27; WO2006IB04122 Applic. Date: 2006-08-04

Inventor: DE RIJK JAN [NL]


Application No.: US20090215726A1  Published: 27/Aug/2009

Title: Phosphono-Pent-2-en-1-yl Nucleosides and Analogs

Applicant/Assignee:

Application No.: 11/887502   Filing Date: 30/Mar/2006

Abstract:Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.

Priority: US20050667740P Applic. Date: 2005-04-01; WO2006US12117 Applic. Date: 2006-03-30

Inventor: HOSTERLER KARL Y [US]; BEADLE JAMES R [US]; CHOO HYUNAH [KR]


Application No.: US20090215776A1  Published: 27/Aug/2009

Title: Organic compounds

Applicant/Assignee:

Application No.: 12/319234   Filing Date: 02/Jan/2009

Abstract:Compounds of formula I in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Priority: EP20080150187 Applic. Date: 2008-01-11; EP20080168207 Applic. Date: 2008-11-03

Inventor: ADCOCK CLAIRE [GB]; BAETTIG URS [GB]; HUNT PETER [GB]; LEBLANC CATHERINE [GB]; PIPET MAUDE NADINE PIERRETTE [GB]; PULZ ROBERT ALEXANDER [CH]; SPIEGEL KATRIN [GB]; STIEFL NIKOLAUS JOHANNES [CH]


Application No.: US20090215849A1  Published: 27/Aug/2009

Title: High stability aqueous gels comprising metronidazole and methods for the preparation thereof

Applicant/Assignee: GALDERMA S.A

Application No.: 11/892292   Filing Date: 21/Aug/2007

Abstract:A method for preparing highly stable aqueous gels based on metronidazole, well suited for treating such skin conditions as rosacea, acne and dermatitis, entails the successive steps of: (A) forming a solvent medium M comprising water and propylene glycol

(B) dissolving the metronidazole in this solvent medium M, and optionally diluting the medium obtained by addition of water, whereby a solution S of metronidazole is obtained

and thence (C) mixing the solution S obtained with a gelling polymer, in a sufficient amount to ensure gelling of the composition.

Priority: US20050671635P Applic. Date: 2005-04-15; WO2006EP02074 Applic. Date: 2006-02-16; FR20050001949 Applic. Date: 2005-02-25

Inventor: ZARIF LEILA [FR]; PEDRASSI GERALD [FR]; BRZOKEWICZ ALAIN [FR]


Application No.: US20090215865A1  Published: 27/Aug/2009

Title: Nucleic Acid Molecules and Collections Thereof, Their Application and Identification

Applicant/Assignee:

Application No.: 12/087566   Filing Date: 10/Jan/2006

Abstract:The invention provides a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) according to the invention or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides new nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.

Priority: WO2006NL00010 Applic. Date: 2006-01-10

Inventor: PLASTERK RONALD H A [NL]; BEREZIKOV EUGENE [NL]; CUPPEN EDWIN P J G [NL]


Application No.: US20090215881A1  Published: 27/Aug/2009

Title: Polyphenolic Bioprecursors

Applicant/Assignee:

Application No.: 11/922331   Filing Date: 16/Jun/2006

Abstract:Cosmetic and therapeutic, in particular dermatological bioprecursors have the formula [A]n-PP-[B]m wherein PP is a polyphenol radical in which each hydroxyl function is protected by a group A or a group B, A is a saturated or unsaturated, substituted or unsubstituted alkyl radical having 1 to 20 carbon atoms which is bonded to the polyphenol, n is an integer not less than 1, and B is a precursor of a biologically active molecule, which is also bonded to the polyphenol, and m is an integer also not less than 1.

Priority: FR20050006169 Applic. Date: 2005-06-17; WO2006FR01375 Applic. Date: 2006-06-16

Inventor: DELAIRE SABINE [FR]; ADAO ADRIEN [FR]; DESMURS JEAN-ROGER [FR]; GELO-PUJIC MIRJANA [FR]; SAINT-JALMES LAURENT [FR]; KASSEM TAREK [FR]


Application No.: US20090216170A1  Published: 27/Aug/2009

Title: SYSTEM AND METHOD FOR HEALING A WOUND AT A TISSUE SITE

Applicant/Assignee:

Application No.: 12/394618   Filing Date: 27/Feb/2009

Abstract:Provided herein is a system and method for facilitating removal of a drape from a tissue site. One aspect provides a system comprising a drape, and adhesive layer, and a release agent, where the system is adapted to be coupled to a tissue site and released therefrom upon or after exposure to an external stimulus. Another aspect provides a method for application and removal of a drape using less force than required with a conventional drape.

Priority: US20080032014P Applic. Date: 2008-02-27

Inventor: ROBINSON TIMOTHY MARK [GB]; KIESWETTER KRISTINE [US]; MCNULTY AMY [US]


Application No.: US20090216204A1  Published: 27/Aug/2009

Title: AUTO-REPLENISHING, WOUND-DRESSING APPARATUS AND METHOD

Applicant/Assignee:

Application No.: 12/341832   Filing Date: 22/Dec/2008

Abstract:Apparatus and methods to treat skin defects include a pump with reservoirs for a pressurization gas and a fluid, the fluid loaded at a factory and sealed or filled at point of use through a valve, septum, or the like. Upon activation, the pump generates a gas introduced into the gas reservoir, a movable wall of which displaces a movable wall of a fluid source, thus dispensing the fluid into the dressing to spread throughout irrespective of orientation of the dressing, maintaining a transport fluid (e.g. carrier) in the dressing and in contact with a skin defect being treated. Delivery may be periodic, constant, programmatically controlled, or manual. A dressing may maintain intimate contact, a transport fluid, and a controllable concentration of active ingredient against a skin defect. Apparatus and methods to replenish a dressing with a therapeutically effective concentration of a fluid deliver a fluid carrier containing an active ingredient. The fluid may be stored in and delivered from a pump mechanism including reservoirs for a pressurization gas and the fluid, which may be loaded at a factory and sealed or filled at point of use through a valve, septum, or the like. The dressing may have a distribution network, and multiple members, dispensing the fluid into a wick maintaining a transport fluid (e.g. carrier) distributed in the dressing and in contact with a skin defect being treated. Delivery may be periodic, constant, programmatically controlled, or manual to maintain intimate contact, a transport fluid, and a controllable concentration of active ingredient against wounded tissue.

Priority: US20080015952P Applic. Date: 2008-02-27

Inventor: BHAVARAJU SAI [US]; DAYTON TROY C [US]; GORDON JOHN HOWARD [US]; HEISER JEREMY [US]; JOSHI ASHOK V [US]


Application No.: US20090220444A1  Published: 03/Sep/2009

Title: Antiperspirant and Deodorant Compositions with Improved Protective Action

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 12/394558   Filing Date: 27/Feb/2009

Abstract:Cosmetic and dermatological antiperspirant and deodorant compositions which have an improved care effect and comprise at least one yoghurt protein and/or at least one hydrolysate of a yoghurt protein and/or at least one N-C2-C24-acyl derivative and/or at least one C2-C24 ester and/or at least one physiologically tolerated salt of these substances.

Priority: DE200610040302 Applic. Date: 2006-08-29; WO2007EP58644 Applic. Date: 2007-08-21

Inventor: TECKENBROCK GERTRAUD [DE]; HEIDE BARBARA [DE]


Application No.: US20090220459A1  Published: 03/Sep/2009

Title: NON-PATHOGENIC AND/OR ATTENUATED BACTERIA CAPABLE OF INDUCING APOPTOSIS IN MACROPHAGES, PROCESS OF MANUFACTURING AND USES THEREOF

Applicant/Assignee: AETERNA ZENTARIS GMBH

Application No.: 12/361843   Filing Date: 29/Jan/2009

Abstract:The invention relates to an non-pathogenic and/or attenuated bacterium which is capable of inducing apoptosis in macrophages.

Priority: EP20080101045 Applic. Date: 2008-01-29; US20080024225P Applic. Date: 2008-01-29

Inventor: FENSTERLE JOACHIM [DE]; GALMBACHER KATHARINA [DE]; RAPP ULF [DE]; GOEBEL WERNER [DE]; HOTZ CHRISTIAN [DE]


Application No.: US20090220483A1  Published: 03/Sep/2009

Title: Stable Enzymatic Preparations and Methods of Use Thereof

Applicant/Assignee: RAMOT AT TEL AVIV UNIVERSITY LTD

Application No.: 12/087108   Filing Date: 27/Dec/2006

Abstract:The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.

Priority: US20050753400P Applic. Date: 2005-12-27; WO2006IL01492 Applic. Date: 2006-12-27

Inventor: FREEMAN AMIHAY [IL]; HADAR NOA [IL]


Application No.: US20090220581A1  Published: 03/Sep/2009

Title: METHODS OF REDUCING INFLAMMATION AND MUCUS HYPERSECRETION

Applicant/Assignee:

Application No.: 11/834446   Filing Date: 06/Aug/2007

Abstract:Methods and compounds for decreasing MARCKS-related inflammation and MARCKS-related mucus hypersecretion or decreasing MARCKS-related inflammation in a subject by the administration of a N-terminal myristoylated protein fragment of the N-terminal region of MARCKS protein or a peptide fragment thereof are disclosed.

Priority:

Inventor: LI YUEHUA [US]; MARTIN LINDA D [US]; ADLER KENNETH B [US]; TAKASHI SHUJI [JP]; PARIKH INDU [US]


Application No.: US20090220585A1  Published: 03/Sep/2009

Title: Biological Active Blood Serum Fraction S-1-10, Methods for Producing It and Uses Thereof

Applicant/Assignee: OWEN HOLDING LTD

Application No.: 12/096295   Filing Date: 08/Dec/2006

Abstract:The present invention relates to a method for preparing a biological active fraction of blood serum, the biological active fraction (S-1-10) and a pharmaceutical composition comprising said fraction as well as uses thereof in the treatment of various diseases and conditions, in particular seizures, cardiovascular diseases and proliferative diseases.

Priority: EP20050027005 Applic. Date: 2005-12-09; US20050749332P Applic. Date: 2005-12-09; WO2006EP11866 Applic. Date: 2006-12-08

Inventor: SHESTAKOV A VITALI [RU]


Application No.: US20090220625A1  Published: 03/Sep/2009

Title: SYNERGISTIC MIXTURES OF BISABOLOL AND GINGER EXTRACT

Applicant/Assignee:

Application No.: 12/090041   Filing Date: 06/Oct/2006

Abstract:Described is a formulation having a skin irritation-reducing action consisting of or comprising: bisabolol and a composition or compound chosen from the group consisting of a) substance mixtures obtainable from an extraction of ginger, b) substance mixtures obtainable from a separation of a ginger extract which comprise a compound which is chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and c) compounds obtainable from a separation of a ginger extract which are chosen from the group consisting of gingerols, shogaols, gingerdiols, dehydrogingerdiones, paradols and derivatives thereof and mixtures thereof, wherein the particular content of bisabolol and of the said composition or compound in the formulation is adjusted such that the skin irritation-reducing action of these contents is increased synergistically.

Priority: US20050726276P Applic. Date: 2005-10-14; WO2006EP67130 Applic. Date: 2006-10-06

Inventor: HERRMANN MARTINA [DE]; VIELHABER GABRIELE [DE]; MEYER IMKE [DE]; JOPPE HOLGER [DE]


Application No.: US20090220627A1  Published: 03/Sep/2009

Title: NOVEL VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION INHIBITORS

Applicant/Assignee:

Application No.: 12/066876   Filing Date: 15/Sep/2006

Abstract:The invention provides anti-aging agents, angiogenesis inhibitors and vascular endothelial growth factor (VEGF) expression inhibitors containing one or more galenicals selected from the group consisting of mukurossi peel extract, hazelnut extract, linden extract, coix extract, chlorella extract and tormentilla extract.

Priority: JP20050269646 Applic. Date: 2005-09-16; JP20050270179 Applic. Date: 2005-09-16; JP20050277870 Applic. Date: 2005-09-26; WO2006JP318793 Applic. Date: 2006-09-15

Inventor: HASEGAWA KIYOTAKA [JP]; INOMATA SHINJI [JP]; UMISHIO KENICHI [JP]


Application No.: US20090221575A1  Published: 03/Sep/2009

Title: Sulfonamide derivatives and use thereof for the modulation of metalloproteinases

Applicant/Assignee: LABORATOIRES SERONO SA

Application No.: 12/091582   Filing Date: 24/Oct/2006

Abstract:The present invention is related to sulfonamide derivatives of Formula (Ia) where the groups are as defined in the description, and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Priority: EP20050110035 Applic. Date: 2005-10-26; US20050730404P Applic. Date: 2005-10-26; WO2006EP67713 Applic. Date: 2006-10-24

Inventor: GERBER PATRICK [CH]; SWINNEN DOMINIQUE [FR]; BOMBRUN AGNES [CH]


Application No.: US20090221625A1  Published: 03/Sep/2009

Title: COSMECEUTICAL COMPOSITION

Applicant/Assignee:

Application No.: 11/912372   Filing Date: 27/Apr/2006

Abstract:Topical compositions comprising: -a physiologically acceptable alkanediol, ether diol or diether alcohol containing up to (8) carbon atoms

-water

and-optionally an unsaturated fatty alcohol

and optionally further conventional excipients, for use as a cosmeceutical, in particular for use in the repair or maintenance of skin barrier function. They are indicated for use in e.g. moisturizing skin, nail and mucosa and, when an optional pharmaceutically active agent is present, additionally in the treatment of various skin, nail and mucosal diseases. Also disclosed are compositions suitable for topical application to infants and babies for treating dry skin, and soothing skin irritated from diaper rash and scrapes.

Priority: GB20050008827 Applic. Date: 2005-04-29; WO2006EP03930 Applic. Date: 2006-04-27

Inventor: HIRSCH STEFAN [DE]; KRIWET KATRIN [DE]; LEDERGERBER DOROTHEA [DE]; MAYER FRIEDRICH KARL [CH]; SEKKAT NABILA [CH]; SCHMIDT KURT [US]; RICHARD WANDA [US]


Application No.: US20090221713A1  Published: 03/Sep/2009

Title: APOE MIMETIC AGENTS

Applicant/Assignee:

Application No.: 12/064117   Filing Date: 09/Aug/2006

Abstract:The invention provides low molecular weight apoE mimetic agents suitable for preparing a medicament to treat autoimmune, inflammatory or neurodegenerative disease, (X)a-L-(X)b(Formula (I)) wherein each X is a (potentially different) chemical moiety bearing a positive charge at physiological pH a and b are, independently, numbers between 3 and 6

and L is a linker.

Priority: GB20050017090 Applic. Date: 2005-08-19; WO2006GB02988 Applic. Date: 2006-08-09

Inventor: GRAINGER DAVID J [GB]; FOX DAVID JOHN [GB]


Application No.: US20090221985A1  Published: 03/Sep/2009

Title: SYSTEM FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF POLYMERIC AGENTS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 12/090675   Filing Date: 19/Oct/2006

Abstract:A system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system that includes an iontophoresis device and a pharmaceutical composition of a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein.

Priority: US20050727828P Applic. Date: 2005-10-19; WO2006IL01206 Applic. Date: 2006-10-19

Inventor: BUKSHPAN SHMUEL [IL]; ZILBERSTEIN GLEB [IL]


Application No.: US20090222072A1  Published: 03/Sep/2009

Title: THERMAL TREATMENT DEVICE

Applicant/Assignee:

Application No.: 12/391337   Filing Date: 24/Feb/2009

Abstract:The present invention is directed to a reusable pain relieving treatment device, such as a belt, and a disposable thermal device having one or more thermally conductive components that extend from a surface of the device and are capable of transferring heat, cold or vibrations from disposable or reusable devices to targeted sections of the user's body.

Priority: US20080031163P Applic. Date: 2008-02-25

Inventor: ROBINSON RONNI L [US]; SOWDEN HARRY S [US]; KRIKSUNOV LEO B [US]


Application No.: US20090226385A1  Published: 10/Sep/2009

Title: Method for Enhancing Dispersion of Inorganic Compounds Using Silicone-Containing Esters and Compositions Formed Therefrom

Applicant/Assignee:

Application No.: 12/044718   Filing Date: 07/Mar/2008

Abstract:A cosmetic composition comprising: (a) an aqueous and/or oil phase comprising: (i) water, and (ii) at least one cosmetically active ingredient

(b) a coupling agent

and (c) an oil phase comprising: (i) an isoparaffin solvent, and (ii) a silicone-containing solvent having the formula:

Priority:

Inventor: HAN WENNING WANG [US]; ZIELINSKI JAMES [US]; PAFFORD BERNIE J [US]


Application No.: US20090226387A1  Published: 10/Sep/2009

Title: SYNTHETIC PEPTIDES FOR USE AS INHIBITORS OF NEUROTRANSMITTER SECRETION AND AS INDUCERS OF CELLULAR RELAXATION

Applicant/Assignee: PARTNERSHIP & CORP. TECHNOLOGY TRANSFER

Application No.: 12/158775   Filing Date: 22/Dec/2006

Abstract:The present invention describes materials and methods related to synthetic peptides which block the secretion of neurotransmitters and induce muscle relaxation, and use of said peptides as inhibitors of neurotransmitter secretion and muscle contraction, and as inducers of muscle relaxation.

Priority: US20050753607P Applic. Date: 2005-12-23; WO2006EP12501 Applic. Date: 2006-12-22

Inventor: FASEL NICOLAS [CH]; KUENDIG AMAL [CH]


Application No.: US20090226472A1  Published: 10/Sep/2009

Title: Interleukin-4 receptors

Applicant/Assignee:

Application No.: 11/986376   Filing Date: 20/Nov/2007

Abstract:Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.

Priority: US2003-688495 Applic. Date: 2003-10-17; US2002-104590 Applic. Date: 2002-03-22; US1998-094917 Applic. Date: 1998-06-15; US1990-480694 Applic. Date: 1990-02-14; US1989-370924 Applic. Date: 1989-06-23; US1989-326156 Applic. Date: 1989-03-20; US1989-319438 Applic. Date: 1989-03-02; US1988-265047 Applic. Date: 1988-10-31

Inventor: MOSLEY BRUCE A [US]; COSMAN DAVID J [US]; PARK LINDA S [US]; BECKMANN M PATRICIA [US]; MARCH CARL J [US]; IDZERDA REJEAN [US]


Application No.: US20090226491A1  Published: 10/Sep/2009

Title: Water-based delivery systems

Applicant/Assignee:

Application No.: 12/290455   Filing Date: 30/Oct/2008

Abstract:The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

Priority: US2004-957320 Applic. Date: 2004-09-30; US2003-388371 Applic. Date: 2003-03-13; WO2003US07752 Applic. Date: 2003-03-13; US20020365059P Applic. Date: 2002-03-13

Inventor: SKOLD THOMAS [SE]


Application No.: US20090226492A1  Published: 10/Sep/2009

Title: USE OF AN ACTIVATED ZEOLITE AS A PHARMACEUTICAL AGENT FOR REDUCING TOXIC SUBSTANCES

Applicant/Assignee:

Application No.: 12/092460   Filing Date: 04/Nov/2006

Abstract:The invention relates to the use of an activated and modified zeolite as a pharmaceutical agent for diseases of the metabolic organs, particularly the liver, kidneys and pancreas by adsorbing heavy metals such as lead and mercury and/or ammonia in the digestive tract of humans and animals and for their evacuation from the organism. The particles of the zeolite have a particle size ranging from 2 to 9 mum, zeta potentials ranging from 20 to 26 mV and a specific surface area ranging from 30 to 38 m2/g. Additional applications include use in cases of food intolerance and food allergies, for treating open or closed wounds in a powder or cream form, for skin diseases and viral infections, for skin care and skin regeneration, as cosmetic agents for skin care and skin regeneration, and for taking up and evacuating mercury and amalgam in the tooth and jawbone region of humans.

Priority: DE200510053090 Applic. Date: 2005-11-04; WO2006DE01951 Applic. Date: 2006-11-04

Inventor: DANZ HUBERT [DE]; GORNER THOMAS [DE]; HOFFMANN STEFFEN [DE]; WOGE OLIVER [DE]


Application No.: US20090226497A1  Published: 10/Sep/2009

Title: Alcohol Antimicrobial Skin Sanitizing Compositions Including Cationic Compatible Thickeners

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 12/044550   Filing Date: 07/Mar/2008

Abstract:The present disclosure generally relates to alcohol antimicrobial skin sanitizing compositions for use in hand washing and skin sanitizing. The antimicrobial skin sanitizing composition comprises an alcohol for providing effective antimicrobial control, one or more cationic compounds for moisturizing and protecting the skin, and a compatible thickening system for thickening the antimicrobial skin sanitizing composition. The antimicrobial skin sanitizing compositions can be used alone or in combination with personal care products.

Priority:

Inventor: CUNNINGHAM COREY THOMAS [US]; SEIDLING JEFFERY RICHARD [US]; WENZEL SCOTT W [US]; MUNDSCHAU STACY AVERIC [US]


Application No.: US20090226507A1  Published: 10/Sep/2009

Title: HYDROXIDE-RELEASING AGENTS AS SKIN PERMEATION ENHANCERS

Applicant/Assignee:

Application No.: 12/247624   Filing Date: 08/Oct/2008

Abstract:A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

Priority: US2005-303614 Applic. Date: 2005-12-16; US2003-371352 Applic. Date: 2003-02-19; US2000-738410 Applic. Date: 2000-12-14; US2000-569889 Applic. Date: 2000-05-11; US1999-465098 Applic. Date: 1999-12-16

Inventor: LUO ERIC C [US]; JACOBSON ERIC C [US]; HSU TSUNG-MIN [US]


Application No.: US20090226521A1  Published: 10/Sep/2009

Title: Active nanoparticles and method of using

Applicant/Assignee: STC . UNM

Application No.: 12/313847   Filing Date: 25/Nov/2008

Abstract:Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

Priority: US20070004324P Applic. Date: 2007-11-26

Inventor: SMYTH HUGH D [US]; OSINSKI MAREK [US]; MCGILL SHAYNA L [US]


Application No.: US20090226555A1  Published: 10/Sep/2009

Title: EXTRACT OF ACTINIDIA ARGUTA FOR PREVENTING AND TREATING BALDNESS DISORDERS AND SEBORRHEIC SKIN DISORDERS

Applicant/Assignee: HELIXIR CO., LTD

Application No.: 11/573445   Filing Date: 08/Feb/2007

Abstract:The present invention relates to a use of a crude extract, non-polar solvent soluble extract or purified extract of the hardy kiwifruit for the preparation of therapeutic agent for treating and preventing baldness disorder and seborrheic skin disease in human and mammal, and health care food, food additives, feed additives, cosmetic composition comprising the same. The hardy kiwifruit reduced blood DHT level, promoted the formation of hair root in mouse model experiment, and inhibited the failing out of hair and improved seborrheic skin disease of volunteers such as keratigenous skin, seborrhea etc.

Priority: WO2004KR02010 Applic. Date: 2004-08-10

Inventor: KIM BONGCHEOL [KR]; EO HAE KWAN [KR]; LEE HWA-JUN [KR]; JIN MIRIM [KR]; JUNG HYUNG-JIN [KR]; KIM SUNYOUNG [KR]


Application No.: US20090227482A1  Published: 10/Sep/2009

Title: LIQUID CLEANSING COMPOSITION

Applicant/Assignee:

Application No.: 11/814043   Filing Date: 03/Feb/2006

Abstract:A personal cleansing composition exhibiting enhanced skin feel (i.e., enhanced skin softness, reduced skin irritation, reduced residue, and reduced greasy, tacky, or tight skin feel), enhanced foaming and lather, and good cleansing, more specifically, a personal cleansing composition comprising a mixture of alpha sulfonated alkyl esters or sulfonated fatty acids, or salts thereof, with an alkyl sulfoacetate or ethoxylated alkyl sulfoacetate, or salts thereof, secondary surfactants, and optional additives.

Priority: US20050650020P Applic. Date: 2005-02-04; WO2006US03962 Applic. Date: 2006-02-03

Inventor: DONG XUE MIN [US]; SAJIC BRANKO [US]; SHAPIRO IRENE [US]; TONG MINH [US]; ZAMORSKI JOHN FRANK [US]


Application No.: US20090227507A1  Published: 10/Sep/2009

Title: Angiotensin (1-7) Dosage Forms and Uses Thereof

Applicant/Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA

Application No.: 12/400370   Filing Date: 09/Mar/2009

Abstract:The present invention provides angiotensin (1-7) pharmaceutical compositions, dosage forms, and methods for their use, and methods for treating or limiting development of acquired immune deficiency syndrome.

Priority: US20080035247P Applic. Date: 2008-03-10; US20080095052P Applic. Date: 2008-09-08

Inventor: RODGERS KATHLEEN E [US]; DIZEREGA GERE S [US]


Application No.: US20090227545A1  Published: 10/Sep/2009

Title: METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND

Applicant/Assignee:

Application No.: 12/399070   Filing Date: 06/Mar/2009

Abstract:Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-19-nor-20(S)-1alpha-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1alpha,25-dihydroxyvitamin D3, 2-methylene-19-nor-(24R)-1alpha,25-dihydroxyvitamin D2, 2-methylene-1alpha,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1alpha,25-dihydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1alpha,25-dihydroxyvitamin D3, 2-methylene-19-nor-1alpha-hydroxy-pregnacalciferol, 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-19-nor-1alpha-hydroxy-trishomopregnacalciferol, 2-methylene-(20R)-23,23-difluoro-1alpha-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1alpha-hydroxy-19-nor-bishomopregnacalciferol, 2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1alpha-hydroxyvitamin D3, or 13,13-dimethyl-des-C,D analog of (20S)-2-methylene-1alpha,25-dihydroxy-19-nor-vitamin D3, and pharmaceutical topical formulations and topical dosage forms thereof using a pharmaceutically suitable carrier vehicle.

Priority: US20080034401P Applic. Date: 2008-03-06

Inventor: DELUCA HECTOR F [US]; CLAGETT-DAME MARGARET [US]; PLUM LORI A [US]; NIEVES NIRCA J [US]; AHRENS JAMIE [US]


Application No.: US20090227548A1  Published: 10/Sep/2009

Title: Novel Glucocorticoid Receptor Agonists

Applicant/Assignee:

Application No.: 12/276925   Filing Date: 24/Nov/2008

Abstract:This Invention Relates To Novel Glucocorticoid Receptor Agonists of Formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

Priority: US20070991354P Applic. Date: 2007-11-30; US20080057241P Applic. Date: 2008-05-30; US20080079555P Applic. Date: 2008-07-10

Inventor: GLOSSOP PAUL ALAN [GB]; MILLAN DAVID SIMON [GB]; PRICE DAVID ANTHONY [US]


Application No.: US20090230013A1  Published: 17/Sep/2009

Title: User-Customizable Dosing System

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/405438   Filing Date: 17/Mar/2009

Abstract:A customizable dosing system is provided, comprising a primary container comprising at least one enclosure, the enclosure containing a dosage unit comprising an active

indicia for selection or deselection of one or more of the dosage units and actives

wherein the indicia enables a user to select a system and one or more dosage units and actives appropriate to a user's needs. Also provided are methods of customizing dosage and treatment, and kits containing a customizable dosing system and one or more complimentary products.

Priority: US20080069723P Applic. Date: 2008-03-17

Inventor: BORN JASON ALAN [US]; DOAN DEBORAH M [US]; CRISS SUSAN ELAINE [US]


Application No.: US20090232743A1  Published: 17/Sep/2009

Title: Foamable Microemulsion Compositions for Topical Administration

Applicant/Assignee: COLLEGIUM PHARMACEUTICAL, INC

Application No.: 12/371155   Filing Date: 13/Feb/2009

Abstract:Described are ethanol-free foamable microemulsions for topical application, and method of making them. The propellants used in the compositions may be environmentally-friendly hydrofluoroalkanes. The foam compositions may also comprise one or more of a variety of active ingredients, including anti-inflammatory agents, anesthetics, and keratolytic agents.

Priority: US20080028586P Applic. Date: 2008-02-14

Inventor: VARANASI RAVI K [US]; RARIY ROMAN V [US]


Application No.: US20090232750A1  Published: 17/Sep/2009

Title: Compositions for indoor tanning

Applicant/Assignee:

Application No.: 12/075624   Filing Date: 13/Mar/2008

Abstract:Compositions for inducing a natural tan of the skin is disclosed. The compositions contain D-ribose as the active ingredient plus a penetrant to deliver D-ribose to the basal cells and dermis of the skin. Compositions further containing emollients and emulsifiers are preferred.

Priority:

Inventor: ST CYR JOHN A [US]


Application No.: US20090232751A1  Published: 17/Sep/2009

Title: High Sunscreen Efficiency Water-in-Oil Emulsion

Applicant/Assignee:

Application No.: 12/084908   Filing Date: 13/Nov/2006

Abstract:The present invention relates to highly stable water-in-oil sunscreen emulsions that provide a high sunscreen efficiency ("SE") having a sun protection factor ("SPF") of X, where X is at least about 15, and having a sunscreen efficiency ("SE") of at least 2, preferably at least 3, where SE is the ratio of SPF over the total weight percentage of sunscreen actives based on the total weight of the composition. The emulsions of the present invention provide photoprotection for the period corresponding to the labeled SPF throughout the period of exposure to natural sunlight and comprises (i) at least one sunscreen active and (ii) an alkyl dimethicone copolyol emulsifier in which the water-soluble, alkyl-soluble and silicone-soluble groups of the dimethicone copolyol are in specific ratios to each other.

Preferably, the high SE water-in-oil emulsion comprises both a UV-A sunscreen and UV-B sunscreen. More preferably, the combination of sunscreen actives is photostable.

Priority: US20050737048P Applic. Date: 2005-11-14; WO2006US44110 Applic. Date: 2006-11-13

Inventor: LOTT DENNIS [US]; LEWELLEN KELLY [US]; WIENER GLENN [US]


Application No.: US20090232754A1  Published: 17/Sep/2009

Title: ENHANCED PHOTOSTABILITY OF SUNCARE COMPOSITIONS CONTAINING AVOBENZONE

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 12/392465   Filing Date: 25/Feb/2009

Abstract:The photostability of avobenzone in a sunscreen composition is stabilized against photodegradation using menthyl anthranilate.

Priority: US20080031950P Applic. Date: 2008-02-27

Inventor: MEYER THOMAS A [US]; BEASLEY DONATHAN G [US]


Application No.: US20090232757A1  Published: 17/Sep/2009

Title: Use of gamma-amino butyric acid as a depigmenting agent

Applicant/Assignee:

Application No.: 12/381789   Filing Date: 17/Mar/2009

Abstract:Use of gamma aminobutyric acid, one of its salts or one of its lower alkyl ester or a polyol ester as depigmenting or melano modulating agent.

Priority: FR20060010470 Applic. Date: 2006-11-30; WO2007FR01966 Applic. Date: 2007-11-29

Inventor: COHEN MARCEL GEORGES [FR]


Application No.: US20090232758A1  Published: 17/Sep/2009

Title: Brassocattleya marcella koss orchid extract and use thereof as skin depigmentation agent

Applicant/Assignee: L V M H RECHERCHE

Application No.: 12/382251   Filing Date: 11/Mar/2009

Abstract:This invention relates to an orchid extract of the Brassocattleya Marcella Koss variety, as well as the use thereof in compositions such as cosmetic compositions, intended to depigment the skin, in particular to lighten the complexion or to improve the uniformity of the skin coloring, or to correct or attenuate skin spots or hyperpigmented skin areas.

Priority: FR20080051642 Applic. Date: 2008-03-13

Inventor: ARCHAMBAULT JEAN-CHRISTOPHE [FR]; CAUCHARD JEAN HUBERT [FR]; LAZOU KRISTELL [FR]; BONTE FREDERIC [FR]


Application No.: US20090232771A1  Published: 17/Sep/2009

Title: Method of controlling cell functions

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 11/632459   Filing Date: 12/Jul/2005

Abstract:The present invention provides methods of screening genes associated with cell regeneration, growth and differentiation and regulators for cell regeneration, growth or differentiation

regulators for cell regeneration, growth or differentiation

and so on. More specifically, the present invention provides methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify the genes associated with the regeneration, growth or differentiation of the cell

methods of screening genes associated with cell regeneration, growth and differentiation, which comprises the step of quantitatively analyzing expression levels of multiple genes collectively in a cell having a regeneration, differentiation or growth capability to thereby identify one or more genes that show higher expression levels in the cell or are specific in expression as compared to the other cells

and, the step of contacting at least one candidate substance capable of regulating the functions of the identified genes or their gene products with the cell and comparing changes before and after the contact

and so on.

Priority: JP20040205877 Applic. Date: 2004-07-13; JP20040319580 Applic. Date: 2004-11-02; WO2005JP13220 Applic. Date: 2005-07-12

Inventor: HINUMA SHUJI [JP]; HOSOYA MASAKI [JP]; KUNISADA RIE [JP]


Application No.: US20090232832A1  Published: 17/Sep/2009

Title: Polyclonal antiserum against a universal tumor antigen

Applicant/Assignee: WIDNES COMPANY INC

Application No.: 11/921167   Filing Date: 02/Jun/2006

Abstract:The present invention relates to a polyclonal antiserum against a universal tumor antigen obtainable by (i) eliciting an in vivo humoral response against embryonic tissue in a non-human vertebrate, whereby said embryonic tissue is of the same genetic line as the non-human vertebrate

(ii) recovering from the immunized non-human animal spleen and isolating from said spleen individual spleen cells/lymphocytes

(iii) eliciting a second in vivo humoral response to the isolated spleen cells/lymphocytes suspension obtained in step (ii) in a further non-human animal of the same genetic line as the non-human animal of step (i)

and (iv) isolating the desired polyclonal antiserum from said animal. Furthermore, the invention provides for the use of the polyclonal antiserum for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of cancer, in particular cancer of the breast, lung, prostate, uterus, colon, stomach or bladder. Additionally the invention relates to the use of the polyclonal serum of the invention for the preparation of a pharmaceutical composition, wherein said pharmaceutical composition is to be administered to a subject in need of treatment in combination with a further anti-proliferative drug or medicament.

Priority: EP20050012053 Applic. Date: 2005-06-03; WO2006EP05269 Applic. Date: 2006-06-02

Inventor: LUONGO CESPEDES ALVARO JOAQUIN [UY]; BATTISTONI SPINELLI JULIO JOSE [UY]; LAMAS ALFONSIN ALVARO LUIS [UY]


Application No.: US20090232849A1  Published: 17/Sep/2009

Title: METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

Applicant/Assignee: UNIVERSITE CATHOLIQUE DE LOUVAIN

Application No.: 11/817223   Filing Date: 17/Oct/2005

Abstract:Compositions and a method for sensitizing a cancer for treatment by cytotoxic therapy is disclosed. The method includes the step of administering to the cancerous tissue or cells a pharmaceutical composition containing a Botulinum toxin, BT.

Priority: EP20050447045 Applic. Date: 2005-03-03; WO2005EP11145 Applic. Date: 2005-10-17

Inventor: GALLEZ BERNARD [BE]; ANSIAUX REGINALD [BE]


Application No.: US20090232851A1  Published: 17/Sep/2009

Title: SIMULTANEOUS, SEPARATE OR SEQUENTIAL THERAPEUTIC USE OF AT LEAST ONE BOTULINUM NEUROTOXIN AND OF AT LEAST ONE OPIATE DERIVATIVE

Applicant/Assignee:

Application No.: 12/305191   Filing Date: 11/Jun/2007

Abstract:The present invention relates to a composition comprising: at least one botulinum neurotoxin, and at least one opiate derivative or its salt. The invention also relates to a product comprising at least one botulinum neurotoxin and at least one opiate derivative or its salt, as a combination product for simultaneous, separate or sequential therapeutic use in the treatment or prevention of pain and of neuromuscular disorders.

Priority: FR20060005368 Applic. Date: 2006-06-16; WO2007FR00956 Applic. Date: 2007-06-11

Inventor: AUGUET MICHEL [FR]; FAVRE CHRISTINE [FR]; CHABRIER DE LASSAUNIERE PIERRE [FR]


Application No.: US20090232855A1  Published: 17/Sep/2009

Title: Percutaneous controlled releasing material using nano-sized polymer particles and external application agent containing the same

Applicant/Assignee:

Application No.: 09/878712   Filing Date: 11/Jun/2001

Abstract:A percutaneous releasing material and agent having characteristics that include a high stability of an active agent in the formulation, a high topical absorption rate, decreased irritation on the skin, and an increased tactile comfort. The percutaneous releasing material incorporates an external application agent composition that is prepared by using nanometer-sized polymer particles, i.e., particles having a size or diameter between approximately 1 nm and approximately 500 nm, and more preferably having a size between about 30 nm and about 150 nm. Further, the percutaneous releasing material and agent according to the present invention incorporate polymer particles that preferably contain a physiologically active agent that more readily penetrates through the stratum corneum to the upper layer of the dermis, whereby the physiologically active agent is effused into the skin while staying in the upper layer of dermis.

Priority: KR20010019869 Applic. Date: 2001-04-13

Inventor: KWON SUN SANG [KR]; YOO BYUNG HEE [KR]; NAM YOON SUNG [KR]; KIM BAE HWAN [KR]; KU BONG SEOK [KR]; HAN SANG HOON [KR]; CHANG IH SEOP [KR]; LEE JONG SUK [KR]


Application No.: US20090232856A1  Published: 17/Sep/2009

Title: STABLE THREE-PHASED EMULSIONS

Applicant/Assignee: MARY KAY INC

Application No.: 12/253624   Filing Date: 17/Oct/2008

Abstract:Disclosed is a three-phase emulsion comprising an aqueous-gel outer phase

and a water-in-oil inner phase, wherein the emulsion is stable. The aqueous-gel outer phase can include 10% to 50% by weight of the total weight of the emulsion. This phase can also include 70% to 95% by weight of water based on the total weight of the aqueous-gel outer phase, a gelling agent, and an emulsifier having a hydrophilic-lipophilic balance (HLB) value of 10 to 19. The water-in-oil inner phase can include 50% to 95% by weight based on the total weight of the three-phase emulsion. This phase can also include 50% to 80% by weight of water based on the total weight of the water-in-oil inner phase, 20% to 50% by weight of oil based on the total weight of the water-in-oil inner phase, and an emulsifier.

Priority: US20080035666P Applic. Date: 2008-03-11

Inventor: PATEL AMIT [US]


Application No.: US20090232857A1  Published: 17/Sep/2009

Title: METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 12/328469   Filing Date: 04/Dec/2008

Abstract:The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Priority: US2008-047309 Applic. Date: 2008-03-12

Inventor: PEPPAS NICHOLAS A [US]


Application No.: US20090232892A1  Published: 17/Sep/2009

Title: Cellooligosaccharide-Containing Composition

Applicant/Assignee:

Application No.: 12/088218   Filing Date: 27/Sep/2006

Abstract:Disclosed is a cellooligosaccharide composition comprising, as the main ingredient, at least one cellooligosaccharide selected from the group consisting of cellobiose, cellotriose, cellotetraose, cellopentaose and cellohexaose, which is in the powdery form having an average L/D value of 3.0 or lower, a bulk density of 0.80 g/mL or lower and an angle of repose of 60 DEG or lower.

Priority: JP20050279157 Applic. Date: 2005-09-27; WO2006JP319119 Applic. Date: 2006-09-27

Inventor: YAMASAKI NAOAKI [JP]; IBUKI ICHIRO [JP]; YAGINUMA YOSHIHITO [JP]; TAMURA YOSHINAGA [JP]


Application No.: US20090233829A1  Published: 17/Sep/2009

Title: MULTIPHASE CLEANING COMPOSITIONS HAVING IONIC LIQUID PHASE

Applicant/Assignee:

Application No.: 12/471763   Filing Date: 26/May/2009

Abstract:A multiphase cleaning composition comprises a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase. The first phase may comprise, for example, an aqueous phase or a silicone solvent system. Methods of cleaning a soiled surface comprise contacting a soiled surface with a multiphase wash liquor including a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase, and removing soils from the surface.

Priority: US2005-263392 Applic. Date: 2005-10-31; US20040624127P Applic. Date: 2004-11-01

Inventor: HECHT STACIE ELLEN [US]; PRICE KENNETH NATHAN [US]; BERGER PATRICIA SARA [US]; FOLEY PETER ROBERT [US]; HUTTON III HOWARD DAVID [US]; SHOWELL MICHAEL STANFORD [US]; GARDNER ROBB RICHARD [US]; NIEHOFF RAYMOND LOUIS [US]; SEDDON KENNETH RICHARD [GB]; GUNARATNE HARAMBAGE QUINTAS NIMAL [GB]; EARLE MARTYN [GB]


Application No.: US20090233902A1  Published: 17/Sep/2009

Title: INDOLOPYRIDINES AS EG5 KINESIN MODULATORS

Applicant/Assignee:

Application No.: 12/280424   Filing Date: 21/Feb/2007

Abstract:Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.

Priority: EP20060110295 Applic. Date: 2006-02-22; EP20060119038 Applic. Date: 2006-08-16; WO2007EP51688 Applic. Date: 2007-02-21

Inventor: VENNEMANN MATTHIAS [DE]; BAR THOMAS [DE]; BRAUNGER JUERGEN [DE]; ZIMMERMANN ASTRID [DE]; GEKELER VOLKER [DE]


Application No.: US20090233954A1  Published: 17/Sep/2009

Title: METHODS AND SYSTEMS FOR PROGNOSIS OF A PATIENT'S RESPONSE TO TREATMENT OF ANDROGENETIC SKIN DISORDERS

Applicant/Assignee:

Application No.: 12/202080   Filing Date: 29/Aug/2008

Abstract:Methods and systems are described for prediction of a patient's response to a drug for treating androgenetic skin disorders such as alopecia, acne, and hirsutism. For a given drug such as anti-androgens and 5-alpha-reductase inhibitors, and a given dosage, the likely responsiveness of that drug and dosage may be determined, for example, by generating a set of patient scores based on a patient profile, including genetic sample information, and comparing that scores to a set of reference information.

Priority: US20080069215P Applic. Date: 2008-03-12; US20080126325P Applic. Date: 2008-05-01; US20080060313P Applic. Date: 2008-06-10; US20080078323P Applic. Date: 2008-07-03

Inventor: GOREN ANDY OFER [US]; KEENE SHARON [US]


Application No.: US20090233982A1  Published: 17/Sep/2009

Title: Methyltransferases and Their Uses

Applicant/Assignee:

Application No.: 11/887845   Filing Date: 03/Mar/2006

Abstract:The identification and cloning of Misu polypeptide are disclosed and in particular full length human and murine Misu polypeptides. The Misu polypeptides are shown to have methyltransferase activity for a range of nucleic acid substrates. The uses of these polypeptides and nucleic acid molecules are disclosed, for example for screening for compounds that are capable of modulating a Misu biological activity, and the use of Misu inhibitors for the treatment of cancer.

Priority: US20050658535P Applic. Date: 2005-03-04; WO2006GB00796 Applic. Date: 2006-03-03

Inventor: FRYE MICHAELA [GB]; WATT FIONA [GB]


Application No.: US20090233996A1  Published: 17/Sep/2009

Title: AVERMECTIN/BENZOYL PEROXIDE COMPOSITIONS FOR TREATING AFFLICTIONS OF THE SKIN, E.G., ROSACEA

Applicant/Assignee: GALDERMA S.A

Application No.: 12/472404   Filing Date: 27/May/2009

Abstract:Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and benzoyl peroxide, are useful for treating afflictions of the skin, especially rosacea.

Priority: FR20050005917 Applic. Date: 2005-06-10; US2007-000181 Applic. Date: 2007-12-10; WO2006FR01300 Applic. Date: 2006-06-08

Inventor: KAOUKHOV ALEXANDRE [FR]; PERNIN COLETTE [FR]


Application No.: US20090234308A1  Published: 17/Sep/2009

Title: Transdermal systems having control delivery system

Applicant/Assignee: MYLAN TECHNOLOGIES, INC

Application No.: 12/454782   Filing Date: 22/May/2009

Abstract:Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.

Priority: US2005-062084 Applic. Date: 2005-02-18

Inventor: JACKSON KRISTIN [US]; MILLER II KENNETH J [US]; BHAT PAVAN [US]


Application No.: US20090238763A1  Published: 24/Sep/2009

Title: HIGH PENETRATION COMPOSITIONS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/351804   Filing Date: 09/Jan/2009

Abstract:The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.

Priority: WO2006IB52318 Applic. Date: 2006-07-09; WO2006IB52461 Applic. Date: 2006-07-18; WO2006IB52549 Applic. Date: 2006-07-25; WO2006IB52563 Applic. Date: 2006-07-26; WO2006IB52575 Applic. Date: 2006-07-27; WO2006IB52732 Applic. Date: 2006-08-08; WO2006IB52815 Applic. Date: 2006-08-15; WO2006IB53090 Applic. Date: 2006-09-03; WO2006IB53741 Applic. Date: 2006-10-11

Inventor: YU CHONGXI [US]; XU LINA [CN]


Application No.: US20090238874A1  Published: 24/Sep/2009

Title: BIOMIMETIC COMPOSITION REINFORCED BY A POLYELECTROLYTIC COMPLEX OF HYALURONIC ACID AND CHITOSAN

Applicant/Assignee: TISSUE ENGINEERING CONSULTANTS, INC

Application No.: 12/410537   Filing Date: 25/Mar/2009

Abstract:The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and a polyelectrolytic complex of hyaluronic acid and chitosan. These three components in combination constitute an initial microenvironment for support of stromal cells, and their undifferentiated mesenchymal cell progeny. The tissue engineering device and method of forming the same comprising hyaluronic acid and chitosan and the use of said device with compositions of pluripotent cells and various formulations of cell culture media for repair of tissues is disclosed.

Priority: US2004-999848 Applic. Date: 2004-11-30; US20030525965P Applic. Date: 2003-12-01

Inventor: BREKKE JOHN H [US]


Application No.: US20090238897A1  Published: 24/Sep/2009

Title: REMOVAL OF SKIN CHANGES

Applicant/Assignee:

Application No.: 12/294017   Filing Date: 21/Mar/2006

Abstract:The present invention relates to the field of skin disorders, particularly to the prevention and/or treatment of benignant or malignant changes of the epidermis visible in form of e.g. nevus. A pharmaceutical, dermatological and/or cosmetic composition is disclosed comprising as active constituent the boroxine compound. The present invention further provides the respective uses of the boroxine compound in medicine, particularly in the field of skin disorders, and in dermatological and/or cosmetic applications.

Priority: WO2006IB02033 Applic. Date: 2006-03-21

Inventor: GALIC BORIVOJ [BA]


Application No.: US20090239247A1  Published: 24/Sep/2009

Title: MN and Hypoxia

Applicant/Assignee:

Application No.: 12/396879   Filing Date: 03/Mar/2009

Abstract:The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

Priority: US2005-166997 Applic. Date: 2005-06-24; US2002-319003 Applic. Date: 2002-12-13; US20040598941P Applic. Date: 2004-08-05; US20050649661P Applic. Date: 2005-02-03

Inventor: HARRIS ADRIAN L [GB]; RATCLIFFE PETER J [GB]; VORDERMARK DIRK [DE]


Application No.: US20090239828A1  Published: 24/Sep/2009

Title: Adhesive preparation

Applicant/Assignee:

Application No.: 12/310876   Filing Date: 10/Sep/2007

Abstract:The present invention provides an adhesive preparation having a plaster layer disposed on a support, the adhesive preparation comprising at least one active ingredient selected from the group consisting of a bisphosphonic acid derivative, its salt thereof and a hydrate of either of the bisphosphonic acid derivative or the salt, a solubilizer for the active ingredient, propylene glycol, a hydrogenated terpene resin, an adhesive base, and a softening agent in the plaster layer.

Priority: JP20060245965 Applic. Date: 2006-09-11; WO2007JP67597 Applic. Date: 2007-09-10

Inventor: YAMAZAKI YUUHIRO [JP]; HAYASHI NORIYUKI [JP]; SAKAI YOSHIKI [JP]


Application No.: US20090239877A1  Published: 24/Sep/2009

Title: NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF

Applicant/Assignee: AETERNA ZENTARIS GMBH CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE UNIVERSITY OF MONTPELLIER I UNIVERSITY OF MONTPELLIER II

Application No.: 12/405588   Filing Date: 17/Mar/2009

Abstract:The invention provides 1,2,4-triazole compounds, compositions containing those compounds, methods of treating diseases and/or disorders with those compounds and processes of manufacturing 1,2,4-triazole compounds.

Priority: EP20080102647 Applic. Date: 2008-03-17; US20080037018P Applic. Date: 2008-03-17

Inventor: FEHRENTZ JEAN-ALAIN [FR]; BIBIAN MATHIEU [FR]; MOULIN ALINE [FR]; MARTINEZ JEAN [FR]


Application No.: US20090240033A1  Published: 24/Sep/2009

Title: AFFINITY MATRIX LIBRARY AND ITS USE

Applicant/Assignee:

Application No.: 12/402272   Filing Date: 11/Mar/2009

Abstract:The invention relates, at least in part, to an affinity matrix library and the construction and use thereof. The library may be used, for example, for the enrichment of low-abundance proteins and depletion of abundant proteins in the search for biologically important proteins. The present invention also relates to a synthetic affinity matrix library comprising one or more ligand compounds with groups selected from amino, sulfhydryl, hydroxyl, carbonyl, and/or active hydrogen. The ligand compound may be attached to a base matrix.

Priority: US20080069094P Applic. Date: 2008-03-11

Inventor: LI RONGXIU [CN]


Application No.: US20090246169A1  Published: 01/Oct/2009

Title: INDOLOPYRIDINES AS EG5 KINESIN MODULATORS

Applicant/Assignee:

Application No.: 12/280264   Filing Date: 21/Feb/2007

Abstract:Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.

Priority: EP20060110298 Applic. Date: 2006-02-22; WO2007EP51691 Applic. Date: 2007-02-21

Inventor: VENNEMANN MATTHIAS [DE]; BAR THOMAS [DE]; BRAUNGER JUERGEN [AT]; ZIMMERMANN ASTRID [DE]; GEKELER VOLKER [DE]


Application No.: US20090246198A1  Published: 01/Oct/2009

Title: MAPK/ERK KINASE INHIBITORS AND METHODS OF USE THEREOF

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 12/415573   Filing Date: 31/Mar/2009

Abstract:Compounds of the following formula are provided: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20080040811P Applic. Date: 2008-03-31

Inventor: DONG QING [US]; JIN BOHAN [US]


Application No.: US20090246202A1  Published: 01/Oct/2009

Title: Human Endokine Alpha and Methods of Use

Applicant/Assignee: HUMAN GENOME SCIENCES, INC

Application No.: 12/370897   Filing Date: 13/Feb/2009

Abstract:The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

Priority: US2006-427956 Applic. Date: 2006-06-30; US2002-136511 Applic. Date: 2002-05-02; US2000-513584 Applic. Date: 2000-02-25; US1999-345790 Applic. Date: 1999-07-01; US1997-912227 Applic. Date: 1997-08-15; US19990136788P Applic. Date: 1999-05-28; US19990122099P Applic. Date: 1999-02-26; US19960024058P Applic. Date: 1996-08-16

Inventor: YU GUO-LIANG [US]; NI JIAN [US]; ROSEN CRAIG A [US]


Application No.: US20090246211A1  Published: 01/Oct/2009

Title: Molecular constructs suitable for targeted conjugates

Applicant/Assignee:

Application No.: 11/433071   Filing Date: 11/May/2006

Abstract:The present invention relates generally to effective drug-linker constructs suitable for conjugation with ligands. The present invention also discloses methods of conjugating these constructs with peptides to form the compound of formula I. These methods are readily extended to any hydroxyl, amine or sulfur bearing biologically active molecules. B-X-L1-(L2)m-(L3)n-Y-RL I

Priority: US20050680623P Applic. Date: 2005-05-12

Inventor: HENRI JOHN T [US]; MCCHESNEY JAMES D [US]; LAMB RODGER [US]; VENKATARAMAN SYLESH K [US]


Application No.: US20090247445A1  Published: 01/Oct/2009

Title: In-Shower and Bath Compositions

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER

Application No.: 12/060437   Filing Date: 01/Apr/2008

Abstract:In-the-shower or in-the-bath compositions having a high internal phase emulsion are described. The high internal phase emulsion is a water-in-oil emulsion where active is present in the water phase. The compositions have an initial viscosity which is low and they are suitable to thicken when being applied in the presence of water.

Priority:

Inventor: LOU ANJING [US]; QIU QIANG [US]; LIPS ALEXANDER [US]


Application No.: US20090247472A1  Published: 01/Oct/2009

Title: TYPE 1, 4-NAPHTOQUINONE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USE OF THESE COMPOUNDS AS ANTI-CANCER AGENTS

Applicant/Assignee: FLUOFARMA UNIVERSITE BORDEAUX 1 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Application No.: 12/298307   Filing Date: 25/Apr/2007

Abstract:This invention relates to compounds with the formula (I) given below or one of their pharmaceutically acceptable salts, as a medicine

Formula (I) of pharmaceutical compositions comprising one or more compounds with Formula (I) as active constituent, use of compounds with Formula (I) for the preparation of compositions designed to prevent or treat at least one illness involving an abnormal cellular proliferation, pro-apoptotic compositions and/or anti-proliferative compositions comprising at least one compound with Formula (I)/and the use of compounds with formula (I) as pro-apoptotic and/or anti-proliferative agents.

Priority: FR20060051461 Applic. Date: 2006-04-25; WO2007FR00703 Applic. Date: 2007-04-25

Inventor: DEPIERRE GAELLE [FR]; DESSOLIN JEAN [FR]; LAGUERRE MICHEL [FR]; COMMANDEUR CLAUDE [FR]


Application No.: US20090247490A1  Published: 01/Oct/2009

Title: Topical Compositions Containing Phosphorylated Polyphenols

Applicant/Assignee:

Application No.: 12/481156   Filing Date: 09/Jun/2009

Abstract:The present invention provides topical compositions containing phosphorylated polyphenols in combination with a topically acceptable carrier. The compositions of the invention provide a means for delayed delivery of the polyphenol to keratinous tissues, such as skin, hair and nails, with enzymes of the keratinous tissue dephosphorylating the polyphenol, and returning it to its native active form. The compositions are particularly useful in the regulation of skin conditions. the phosphorylated stilbene is a phosphorylated resveratrol or a phosphorylated resveratrol derivative.

Priority: US2007-574252 Applic. Date: 2007-02-26; WO2004BE00132 Applic. Date: 2004-09-14

Inventor: DECLERCQ LIEVE [BE]; CORSTJENS HUGO [BE]; MAES DANIEL [US]; VAN BRUSSEL WILLY [BE]; SCHELKENS GEERT [BE]


Application No.: US20090247554A1  Published: 01/Oct/2009

Title: KINASE INHIBITORS

Applicant/Assignee: TAKEDA SAN DIEGO, INC

Application No.: 12/295124   Filing Date: 27/Mar/2007

Abstract:Compounds are provided for use with kinases that comprise (I), (II), (III), (IV): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20060788515P Applic. Date: 2006-03-30; WO2007US65272 Applic. Date: 2007-03-27

Inventor: DONG QING [US]; WALLACE MICHAEL B [US]


Application No.: US20090247587A1  Published: 01/Oct/2009

Title: 1,3-DIHYDROISOBENZOFURAN DERIVATIVES

Applicant/Assignee: KOWA COMPANY, LTD

Application No.: 12/413894   Filing Date: 30/Mar/2009

Abstract:The object is to provide a novel LXRbeta agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis

arteriosclerosis such as those resulting from diabetes

dyslipidemia

hypercholesterolemia

lipid-related diseases

inflammatory diseases that are caused by inflammatory cytokines

skin diseases such as allergic skin diseases

diabetes

or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.

Priority: US20080041109P Applic. Date: 2008-03-31

Inventor: OKUDA AYUMU [JP]; MATSUDA TAKAYUKI [JP]; MIURA TORU [JP]; YAMAZAKI KOICHI [JP]; YAMAGUCHI YUKI [JP]; KOURA MINORU [JP]; KUROBUCHI SAYAKA [JP]; WATANABE YUUICHIRO [JP]; SHIBUYA KIMIYUKI [JP]


Application No.: US20090247630A1  Published: 01/Oct/2009

Title: DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND AT LEAST ONE FILM-FORMING AGENT AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH

Applicant/Assignee:

Application No.: 12/276584   Filing Date: 24/Nov/2008

Abstract:Topically applicable, reduced-irritant dermatological/cosmetic compositions useful for the prevention/treatment of a variety of keratinization disorders, for example acne vulgaris, contain at least one naphthoic acid compound essentially uniformly distributed therethrough and an amount of at least one hydrophilic film-forming agent, formulated into topically applicable, physiologically acceptable media therefor.

Priority: FR20060051982 Applic. Date: 2006-05-31; WO2007FR51359 Applic. Date: 2007-05-31

Inventor: MALLARD CLAIRE [FR]; FERRARA EVE [FR]


Application No.: US20090247635A1  Published: 01/Oct/2009

Title: METHOD FOR TREATING ANAL PRURITIS AND OTHER PERIANAL DISORDERS

Applicant/Assignee:

Application No.: 12/399770   Filing Date: 06/Mar/2009

Abstract:The invention relates to methods and compositions for the treatment of pruritis ani and other perianal disorders. There are currently few treatments for these conditions, many of which have significant side effects. The methods of the invention involve the administration, in a cream or lotion of pregabalin, an anti-epileptic agent that has pain relieving properties. This topical form of pregabalin may also include the addition of other agents such as immunomodulators, antibiotics or agents that enhance wound healing. This method may be useful as a new and safe treatment for pruritis ani, skin conditions and other anorectal disorders. Previous positive clinical experience suggests that this new treatment is promising for these disorders.

Priority: US20080041211P Applic. Date: 2008-03-31

Inventor: EHRENPREIS ELI [US]


Application No.: US20090252797A1  Published: 08/Oct/2009

Title: TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS

Applicant/Assignee: GALDERMA S.A

Application No.: 12/483604   Filing Date: 12/Jun/2009

Abstract:Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.

Priority: FR20030005048 Applic. Date: 2003-04-24; US2005-255910 Applic. Date: 2005-10-24; WO2004EP04950 Applic. Date: 2004-04-22; US20030468994P Applic. Date: 2003-05-09

Inventor: MANETTA VINCENT [US]; WATKINS GARY R [US]


Application No.: US20090253666A1  Published: 08/Oct/2009

Title: COMPOSITION COMPRISING SARSASAPOGENIN

Applicant/Assignee: SEDERMA

Application No.: 12/309910   Filing Date: 31/Jul/2007

Abstract:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.

Priority: FR20060053262 Applic. Date: 2006-08-03; WO2007IB53020 Applic. Date: 2007-07-31

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]


Application No.: US20090253694A1  Published: 08/Oct/2009

Title: Fused hetrocyclic compounds

Applicant/Assignee: SYNTA PHARMACEUTICALS CORP

Application No.: 12/380007   Filing Date: 20/Feb/2009

Abstract:This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.

Priority: US2004-985627 Applic. Date: 2004-11-10; US20030518788P Applic. Date: 2003-11-10

Inventor: ONO MITSUNORI [US]; SUN LIJUN [US]; WADA YUMIKO [US]; PRZEWLOKA TERESA [US]; LI HAO [US]; DEMKO ZACHARY [US]; CHIMMANAMADA DINESH [US]


Application No.: US20090253828A1  Published: 08/Oct/2009

Title: PARTICLE IN THE SHAPE OF AN ENCAPSULATED DROPLET AND PROCESS FOR MAKING SUCH A PARTICLE

Applicant/Assignee:

Application No.: 12/309860   Filing Date: 23/Jul/2007

Abstract:Particle in the shape of an encapsulated droplet comprising a core material and a shell material surrounding the core material, the shell material containing maleimide groups, preferably a copolymer of maleimide groups. The shell material contains a copolymer of styrene and maleic anhydride derivatives, of which more than 75 mole %, preferably more than 90 mole % is maleimide, and the average particle size is smaller than 300 nm. The particles are obtained by a process comprising by heating between 80 DEG C. and 195 DEG C., more preferably between 120 DEG C. and 190 DEG C. an ammonium salt of a maleic anhydride containing polymer in the presence of the core material.

Priority: EP20060015867 Applic. Date: 2006-07-31; WO2007EP06518 Applic. Date: 2007-07-23

Inventor: VAN DEN ABBEELE HENK JAN FRANS [BE]


Application No.: US20090257962A1  Published: 15/Oct/2009

Title: Compositions for human dental care

Applicant/Assignee:

Application No.: 12/384981   Filing Date: 10/Apr/2009

Abstract:Compositions of the invention are water-based formulas that contain natural ingredients which aid in reduction of bacteria in the mouth, thereby reducing plaque and the production of tartar, and in one aspect of the invention are formulated as potable dental water that may be consumed in place of regular consumption of other forms of water or liquid, and in another aspect of the invention are formulated as dentifrices, such as toothpaste.

Priority: US20080123615P Applic. Date: 2008-04-10

Inventor: ALBERT KAREN L [US]


Application No.: US20090258041A1  Published: 15/Oct/2009

Title: Protection of Oxidizable Agents

Applicant/Assignee:

Application No.: 12/083557   Filing Date: 21/Jun/2006

Abstract:Formulations for cosmetical or pharmaceutical use contain an antioxidant in encapsulated form and a cosmetically or pharmaceutically acceptable carrier. The antioxidant is selected from carbon bridged hindered phenoles, ester bridged hindered phenoles, amide bridged hindered phenoles, lactones of hindered phenoles, sterically hindered oxylamines and sterically hindered hydroxylamines. The encapsulated antioxidant is of high activity and suitable to protect a further active ingredient, e.g. oxidizable natural substances, vitamins, fragrances, and extracts from plants fungi, algae or animals, from premature degradation, especially when coencapsulated together with the ingredient. The formulations are useful inter alia for the preparation of a cosmetical or pharmaceutical skin care or skin delivery formulation, injectable solution, infusion solution, eye drop, drinking solution, a dietary or enriched food, an oral care formulation, drinking gargles, in-halants, or as a food additive.

Priority: WO2005EP55475 Applic. Date: 2005-10-24; WO2006EP63421 Applic. Date: 2006-06-21

Inventor: MONGIAT SEBASTIEN [FR]; BASCHONG WERNER [CH]; HERZOG BERND [DE]


Application No.: US20090258042A1  Published: 15/Oct/2009

Title: Encapsulated Active Materials Containing Adjunct Crosslinkers

Applicant/Assignee:

Application No.: 12/102355   Filing Date: 14/Apr/2008

Abstract:It is an object of the present invention to provide a microcapsule product comprising an active material

said active material encapsulated by a polymeric material to provide a polymer encapsulated material wherein said polymeric material comprises an adjunct crosslinker.

Priority:

Inventor: ANASTASIOU THEODORE JAMES [US]; LODEWIJK JOHAN GERWIN [US]; MCELWEE JEFFREY JAMES [US]


Application No.: US20090258046A1  Published: 15/Oct/2009

Title: COMPOSITION, FORMULATIONS AND KIT FOR TREATMENT OF RESPIRATORY AND LUNG DISEASE WITH NON-GLUCOCORTICOID STEROIDS AND/OR UBIQUINONE AND A BRONCHODILATING AGENT

Applicant/Assignee:

Application No.: 12/430800   Filing Date: 27/Apr/2009

Abstract:A pharmaceutical or veterinary composition, which comprises a first active agent selected from a non-glucocorticoid steroid or analogues, a ubiquinone, or salts thereof, and a second active agent comprising a bronchodilator. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of respiratory, lung and malignant diseases.

Priority: US2004-475689 Applic. Date: 2004-08-12; WO2002US12552 Applic. Date: 2002-04-22; US20010286139P Applic. Date: 2001-04-24

Inventor: NYCE JONATHAN W [US]


Application No.: US20090258058A1  Published: 15/Oct/2009

Title: NOVEL SILICONE FILM FORMER FOR DELIVERY OF ACTIVES

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 12/300875   Filing Date: 23/May/2007

Abstract:The invention provides: a film-forming composition comprising a) a saccharide-siloxane copolymer

b) a crosslinking agent

c) one or more active/inactive ingredients

and d) optionally, a solvent, or solvent mixture, wherein the saccharide-siloxane copolymer has the following formula: R2aR1(3-a)SiO-[(SiR2R1O)m-(SiR12O)n]y-SiR1(3-a)R2a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component

films

and methods related thereto. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.

Priority: US20060802708P Applic. Date: 2006-05-23; WO2007US12260 Applic. Date: 2007-05-23

Inventor: THOMAS XAVIER [FR]; CAPRASSE VIRGINIE [BE]; JOFFRE ERIC JUDE [US]; KOLLAR CSILLA [US]; GANTNER DAVID CLAYTON [US]; RAUL VICTOR A [US]


Application No.: US20090258060A1  Published: 15/Oct/2009

Title: Hydrogel Compositions

Applicant/Assignee:

Application No.: 12/491088   Filing Date: 24/Jun/2009

Abstract:Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto. Films prepared from hydrogel compositions containing or entirely composed of the aforementioned continuous hydrophilic phase can be made translucent, and may be prepared using either melt extrusion or solution casting. A preferred use of the hydrogel compositions is in wound dressings, although numerous other uses are possible as well.

Priority: US2002-137664 Applic. Date: 2002-05-01; US20010288008P Applic. Date: 2001-05-01

Inventor: CLEARY GARY W [US]; PARANDOOSH SHOREH [US]; FELDSTEIN MIKHAIL M [RU]; CHALYKH ANATOLY E [RU]; PLATE NICOLAI A [RU]; KULICHIKHIN VALERY G [RU]


Application No.: US20090258062A1  Published: 15/Oct/2009

Title: Transdermal Therapeutic System Comprising Active Ingredient Particles and Having Increased Active Ingredient Flux

Applicant/Assignee:

Application No.: 12/302065   Filing Date: 30/May/2007

Abstract:The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Priority: DE200610026578 Applic. Date: 2006-06-08; WO2007EP04765 Applic. Date: 2007-05-30

Inventor: HORSTMANN MICHAEL [DE]; SAMETI MOHAMMAD [DE]; JUNG TOBIAS [DE]


Application No.: US20090258093A1  Published: 15/Oct/2009

Title: Use of a brassocattleya marcella koss orchid extract as an active agent to prevent or delay the appearance of signs of cutaneous aging

Applicant/Assignee: L.V.M.H. RECHERCHE

Application No.: 12/382250   Filing Date: 11/Mar/2009

Abstract:The present invention describes the use of an extract from the Brassocattleya marcella Koss orchid, in a cosmetic composition or for the preparation of a cosmetic composition, as a hydrating and/or anti-aging agent designed to prevent or delay the appearance of signs of intrinsic or extrinsic aging of the skin, or to delay these effects.

Priority: FR20080051640 Applic. Date: 2008-03-13

Inventor: CAUCHARD JEAN HUBERT [FR]; ARCHAMBAULT JEAN-CHRISTOPHE [FR]; LAZOU KRISTELL [FR]; BONTE FREDERIC [FR]


Application No.: US20090263339A1  Published: 22/Oct/2009

Title: AGENT FOR EXTERNAL APPLICATION TO THE SKIN

Applicant/Assignee: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKY

Application No.: 11/915608   Filing Date: 26/May/2006

Abstract:The present invention has an object to provide an agent for suppressing melanin production and/or inhibiting elastase activity containing a plant extract as an effective substance with high safety and acceptable levels of stability and odor or sediment formation and an agent for external application to the skin comprising the above agent which has excellent effects in skin-whitening and skin-beautifying. The object is attained by providing an agent for external application to the skin containing indigo-plant extract.

Priority: JP20050155073 Applic. Date: 2005-05-27; JP20050313896 Applic. Date: 2005-10-28; WO2006JP310555 Applic. Date: 2006-05-26

Inventor: KYONO FUMIYO [JP]; SUEMOTO YASUO [JP]; TAKAYAMA SATORU [JP]; TAKEUCHI MAKOTO [JP]


Application No.: US20090263353A1  Published: 22/Oct/2009

Title: Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles

Applicant/Assignee: NYCOMED GMBH

Application No.: 11/992015   Filing Date: 08/Sep/2006

Abstract:Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Priority: EP20050108728 Applic. Date: 2005-09-21; WO2006EP66197 Applic. Date: 2006-09-08

Inventor: MAIER THOMAS [DE]; BECKERS THOMAS [DE]; HUMMEL ROLF-PETER [DE]; FETH MARTIN [DE]; MULLER MATTHIAS [DE]; BAR THOMAS [DE]; VOLZ JURGEN [DE]


Application No.: US20090263473A1  Published: 22/Oct/2009

Title: Nanoliposome Using Esterified Lecithin And Method For Preparing The Same, And Composition For Preventing Or Treating Skin Diseases Comprising The Same

Applicant/Assignee: DAEWOONG CO., LTD

Application No.: 12/375739   Filing Date: 01/Aug/2007

Abstract:The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane

a method for preparing the same

and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70 DEG C. or more), low stability and uniformity, or the like can be solved.

Priority: KR20060072809 Applic. Date: 2006-08-02; WO2007KR03699 Applic. Date: 2007-08-01

Inventor: HONG JOON PIO [KR]; LEE SANG KIL [KR]; KIM WON CHUL [KR]; YOON CHAE HA [KR]; LEE SANG WOOK [KR]; SHIN KYEONG SUN [KR]; PARK SEUNG KOOK [KR]


Application No.: US20090263515A1  Published: 22/Oct/2009

Title: PEST REPELLENT COMPOSITIONS AND METHODS

Applicant/Assignee: ECOSMART TECHNOLOGIES, INC

Application No.: 12/424415   Filing Date: 15/Apr/2009

Abstract:The invention is directed to a topical insect repellent with extended duration of protection and that was obtained by combining natural and organic plant essential oil compounds. The new natural repellent exhibits the longevity and repellency that is comparable to or better than N,N-diethyl-m-toluamide (DEET), a synthetic compound employed in almost all commercial formulations, while at the same time is more acceptable than DEET, which has an unpleasant odor, imparts a greasy feel to the skin, and carries certain health concerns when used on children. The inventive insect repellent, formulated in a suitable carrier repels and incapacitates flying insects and other pests, such as mosquitoes and other biting flies or insects, thus demonstrating the utility of the novel insect repellent for protecting pets and livestock as well as humans. The invention provides an effective means to repel insects, without having deleterious effects on people, pets or the environment compared with prior insect repellant formulations. The repellant formulation disclosed herein may employ natural or organic active ingredient, e.g., plant essential oil compounds.

Priority: US20080045941P Applic. Date: 2008-04-17

Inventor: BESSETTE STEVEN M [US]


Application No.: US20090264372A1  Published: 22/Oct/2009

Title: UTILIZATION OF PEPTIDES AS ACTIVE INGREDIENTS FOR SLIMMING

Applicant/Assignee: SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS SA (VINCIENCE)

Application No.: 12/300597   Filing Date: 11/May/2007

Abstract:A method of using proteins of the SIRT family or of polypeptide or peptide fragments of SIRT proteins as an active ingredient for slimming, alone or in combination with at least one other active agent, in a cosmetic composition or for the preparation of a pharmaceutical and/or dermatological composition. The invention also includes the use of the peptides for treatment of cellulite and/or used to decrease, eliminate or prevent excess fat beneath the skin.

Priority: FR20060004251 Applic. Date: 2006-05-12; WO2007FR00803 Applic. Date: 2007-05-11

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; BOTTA JEAN-MARIE [FR]


Application No.: US20090264412A1  Published: 22/Oct/2009

Title: Combination Therapy Using An 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor And A Glucocorticoid Receptor Agonist To Minimize The Side Effects Associated With Glucocorticoid Receptor Agonist Therapy

Applicant/Assignee: HIGH POINT PHARMACEUTICALS, LLC

Application No.: 12/491659   Filing Date: 25/Jun/2009

Abstract:Combination therapy comprising the administration of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist for treating some forms of cancer, diseases and disorders having inflammation as a component, and to minimize the side effects associated with glucorticoid receptor agonist therapy.

Priority: DK20030000565 Applic. Date: 2003-04-11; DK20030000566 Applic. Date: 2003-04-11; DK20030000567 Applic. Date: 2003-04-11; DK20030000569 Applic. Date: 2003-04-11; DK20030000570 Applic. Date: 2003-04-11; DK20030000571 Applic. Date: 2003-04-11; DK20030000776 Applic. Date: 2003-05-22; DK20030000777 Applic. Date: 2003-05-22; DK20030000972 Applic. Date: 2003-06-27; DK20030000988 Applic. Date: 2003-06-30; DK20030000778 Applic. Date: 2003-05-22; DK20030000989 Applic. Date: 2003-06-30; DK20030000990 Applic. Date: 2003-06-30; DK20030000998 Applic. Date: 2003-07-02; DK20030001910 Applic. Date: 2003-12-22; DK20040000009 Applic. Date: 2004-01-06; US2005-246814 Applic. Date: 2005-10-07; WO2004DK00248 Applic. Date: 2004-04-06

Inventor: KAMPEN GITA CAMILLA TEJLGAARD [DK]; ANDERSEN HENRIK SUNE [DK]


Application No.: US20090264451A1  Published: 22/Oct/2009

Title: 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS

Applicant/Assignee: ROTTAPHARM S.P.A

Application No.: 12/376080   Filing Date: 02/Feb/2009

Abstract:The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases. Formula I:

Priority: WO2006EP65013 Applic. Date: 2006-08-03

Inventor: GIORDANI ANTONIO [IT]; MANDELLI STEFANO [IT]; VERPILIO ILARIO [IT]; ZANZOLA SIMONA [IT]; TARCHINO FRANCESCA [IT]; CASELLI GIANFRANCO [IT]; PIEPOLI TIZIANA [IT]; MAZZARI SILVIO [IT]; MAKOVEC FRANCESCO [IT]; ROVATI LUCIO CLAUDIO [IT]


Application No.: US20090264500A1  Published: 22/Oct/2009

Title: 3-SUBSTITUTED-1,5-DIARLY-2-ALKYL-PYRROLES HIGHLY SELECTIVE AND ORALLY EFFECTIVE COX-2 INHIBITORS

Applicant/Assignee:

Application No.: 12/375650   Filing Date: 06/May/2009

Abstract:This invention relates to 3-substituted-1,5-diaryl-2-alkyl-pyrroles of Formula I, pharmaceutical compositions containing them, and to their use for the pharmacological treatment of pain and COX-2 over-activation associated disorders. Compounds of this invention are new pyrrole derivatives bearing in position-3 of the pyrrole ring, several variously functionalized, not aliphatic, side chains which confer to the compounds a relevant COX-2 potency and selectivity along with a remarkable oral efficacy. Phenyl rings in position-1 and -5 are variously substituted, but compounds of particular interest are those substituted in position-5 with 4-methylsulphonyl-phenyl or with 4-aminosulphonyl-phenyl groups.

Priority: WO2006EP65011 Applic. Date: 2006-08-03

Inventor: CAPPELLI ANDREA [IT]; ANZINI MAURIZIO [IT]; BIAVA MARIANGELA [IT]; MAKOVEC FRANCESCO [IT]; GIORDANI ANTONIO [IT]; CASELLI GIANFRANCO [IT]; ROVATI LUCIO CLAUDIO [IT]


Application No.: US20090264657A1  Published: 22/Oct/2009

Title: Stabilization of body-care and household products against degradation by uv radiation using merocyanine derivatives

Applicant/Assignee:

Application No.: 11/989164   Filing Date: 19/Jul/2006

Abstract:Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.

Priority: EP20050107026 Applic. Date: 2005-07-29; EP20060100600 Applic. Date: 2006-01-19; WO2006EP64388 Applic. Date: 2006-07-19

Inventor: WAGNER BARBARA [DE]; REICH OLIVER [DE]


Application No.: US20090264809A1  Published: 22/Oct/2009

Title: METHOD AND APPARATUS OF LOW STRENGH ELECTRIC FIELD NETWORK-MEDIATED DELNERY OF DRUG, GENE, SIRNA, SHRN, PROTEIN, PEPTIDE, ANTIBODY OR OTHER BIOMEDICAL AND THERAPEUTIC MOLECULES AND REAGENTS IN SKIN, SOFT TISSUE, JOINTS AND BONE

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 12/294313   Filing Date: 02/Apr/2007

Abstract:The illustrated embodiments of the invention include four preferred embodiments: 1) a method and apparatus for the joint and its related soft tissue for bone gene, protein and drug delivery

2) a method and apparatus for gene, protein and drug delivery to an extremity

3) a method and apparatus for delivery of gene, protein and drug delivery to skin and soft tissue

and/or 4) a method and apparatus for delivery of a gene, protein and drug to soft tissue tumor.

Priority: US20060744528P Applic. Date: 2006-04-10; US20060819277P Applic. Date: 2006-07-06; WO2007US08445 Applic. Date: 2007-04-02

Inventor: SEN LUYI [US]


Application No.: US20090264839A1  Published: 22/Oct/2009

Title: DUAL SPRAY CAN TOPICAL DELIVERY DEVICE

Applicant/Assignee:

Application No.: 12/426349   Filing Date: 20/Apr/2009

Abstract:The present invention is directed to a delivery device and method for the sequential delivery of a topical pain relieving composition and an occluding composition. These two compositions are held in a single device that comprises at least two chambers for manual and or pressurized delivery of these compositions to the patient's skin.

Priority: US20080046527P Applic. Date: 2008-04-21

Inventor: KRIKSUNOV LEO B [US]; ROBINSON RONNI L [US]


Application No.: US20090265389A1  Published: 22/Oct/2009

Title: Learned cognitive system

Applicant/Assignee: 24EIGHT

Application No.: 12/414627   Filing Date: 30/Mar/2009

Abstract:Systems, methods, and computer-program products for detection of explicit video content compare pixels of a possible explicit video content with a color histogram reference. Areas of the video content are analyzed using a feature extraction technique using a cognitive learning engine, while multiple levels of weighted classifiers are used to rank particular video content.

Priority: US20080064821P Applic. Date: 2008-03-28

Inventor: KALPAXIS ALEX J [US]


Application No.: US20090266290A1  Published: 29/Oct/2009

Title: Buoyant-capable beverage and food content-sensor

Applicant/Assignee: HEBERT L. BERMAN

Application No.: 12/150505   Filing Date: 28/Apr/2008

Abstract:A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).

Priority:

Inventor: SLIWA JOHN W [US]; ORONSKY BRYAN T [US]; BERMAN HERBERT L [US]; ORONSKY NEIL C [US]


Application No.: US20090269299A1  Published: 29/Oct/2009

Title: Cosmetic Method for use in Smoothing the Skin

Applicant/Assignee: L'OREAL

Application No.: 11/992287   Filing Date: 11/Oct/2006

Abstract:The present invention relates to a cosmetic skin care method, in particular for wrinkled skin, comprising the topical application to the skin of a composition comprising, in a physiologically acceptable medium, at least: one synthetic polymer tightening agent, and fibers. This method is more particularly advantageous for smoothing human skin on the face and/or body and/or to diminish or remove the signs of skin aging, in particular to reduce or remove wrinkles and/or fine lines from the skin.

Priority: FR20050053213 Applic. Date: 2005-10-21; US20050740286P Applic. Date: 2005-11-29; WO2006IB53738 Applic. Date: 2006-10-11

Inventor: CASSIN GUILLAUME [FR]


Application No.: US20090269331A1  Published: 29/Oct/2009

Title: CASPASE-8 AND INFLAMMATION, INFECTION AND WOUND HEALING

Applicant/Assignee: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENTLTD YEDA RESEARCH AND DEVELOPMENT CO., LTD

Application No.: 12/306929   Filing Date: 27/Jun/2007

Abstract:The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing

Priority: IL20060176605 Applic. Date: 2006-06-28; IL20070181094 Applic. Date: 2007-01-31; WO2007IL00786 Applic. Date: 2007-06-27

Inventor: WALLACH DAVID [IL]; ABRAMOVITCH RINAI [IL]; GALUN EITAN [IL]; BEN MOSHE TEHILA [IL]; BARASH HILA [IL]


Application No.: US20090269377A1  Published: 29/Oct/2009

Title: COSMETIC COMPOSITION FOR CARE AND/OR TREATMENT AND/OR MAKEUP OF THE EMULSION TYPE STRUCTURED WITH SILICONE POLYMERS

Applicant/Assignee: L'OREAL

Application No.: 12/481286   Filing Date: 09/Jun/2009

Abstract:Cosmetic emulsion for care and/or makeup, comprising an aqueous phase and a liquid fatty phase dispersed one within the other, said liquid fatty phase comprising at least one silicone oil and being structured with at least one gelling polymer (homopolymer or copolymer) with a weight-average molecular mass ranging from 500 to 500,000, containing at least one moiety comprising: at least one polyorganosiloxane group, composed of 1 to 1000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions chosen from among the ester, amide, sulfonamide, carbamate, thiocarbamate, urea, thiourea, oxamido, guanidino, biguanidino groups, and combinations thereof, on condition that at least one of the groups is other than an ester group, the polymer being solid at room temperature and soluble in the liquid fatty phase at a temperature of 25 to 250 DEG C., the aqueous phase, the liquid fatty phase and the gelling polymer forming a physiologically acceptable medium.

Priority: US2007-684703 Applic. Date: 2007-03-12; US2002-166648 Applic. Date: 2002-06-12

Inventor: LU SHAOXIANG [US]


Application No.: US20090269395A1  Published: 29/Oct/2009

Title: USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT

Applicant/Assignee: SEDERMA

Application No.: 11/991587   Filing Date: 06/Sep/2006

Abstract:The present invention relates to cosmetic use, by topic application on the skin of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an active substance reducing activity of the pilosebaceous unit, preferably inhibiting activity of the pilosebaceous unit. In particular, the invention relates to cosmetic use of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an agent reducing, preferably inhibiting the growth of hairs of the face and/or the body, and/or seborrheic activity of the sebaceous glands. The invention also relates to a cosmetic composition comprising in a dermatologically acceptable carrier, at least one protoberberine, with exception of berberine, or a vegetable extract containing protoberberines, as an active substance, which reduces, preferably inhibits the skin's pilosebaceous unit activity.

Priority: FR20050009100 Applic. Date: 2005-09-06; WO2006IB53136 Applic. Date: 2006-09-06

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]


Application No.: US20090269415A1  Published: 29/Oct/2009

Title: NOVEL THERAPEUTIC AGENT DERIVED FROM MARINE ORGANISM

Applicant/Assignee: IMEX JAPAN CO., LTD

Application No.: 12/065414   Filing Date: 31/Aug/2006

Abstract:There is provided a nerve repairing agent, anti-ulcer agent or the like comprising an extract from a marine organism selected from organisms belonging to the class Holothuroidea, the phylum Porifera and the order Actiniaria or a material removed from a viscus of the organism. The extract has the following properties (1) to (4): (1) it is a almost colorless, transparent and viscous liquid having a slight fishy smell, or a almost white powder having a slight fishy smell which, when dissolved in water, is almost colorless and viscous

(2) a solution prepared by dissolving the liquid or powder in water shows the maximum absorbance at a wavelength of 264+-10 nm

(3) a solution prepared by dissolving the liquid or powder in water shows an acidic pH value

and (4) it has at least one effect selected from a cranial nerve repairing effect, a nerve-growing effect, an insulin-releasing effect, an immunopotentiating effect, a noxious pain preventive effect, a neurogenic pain preventive effect, a diabetic sensory neuropathy ameliorating effect and an ulcer preventive effect.

Priority: JP20050252684 Applic. Date: 2005-08-31; WO2006JP317254 Applic. Date: 2006-08-31

Inventor: FOONG FOO WAH [JP]; KUWABARA MASATO [JP]


Application No.: US20090269418A1  Published: 29/Oct/2009

Title: Compositions and Methods for Inducing Hair Growth

Applicant/Assignee: BIOMAS LTD

Application No.: 11/662743   Filing Date: 15/Sep/2005

Abstract:Novel therapeutic methods and pharmaceutical compositions utilizing tellurium-containing compounds for inducing hair growth for the treatment of various types of alopecia and other conditions associated with hair loss.

Priority: US20040610660P Applic. Date: 2004-09-17; WO2005IL00991 Applic. Date: 2005-09-15

Inventor: ALBECK MICHAEL [IL]; SREDNI BENJAMIN [IL]


Application No.: US20090269419A1  Published: 29/Oct/2009

Title: COSMETIC COMPOSITION BASED ON POLYUNSATURATED FATTY ACIDS AND ITS USES

Applicant/Assignee:

Application No.: 12/307090   Filing Date: 02/Jul/2007

Abstract:The present invention relates to a cosmetic or dermatological composition comprising (i) at least vegetables oils which are rich in omega-3 and/or in omega-6, selected from the group consisting of echium oil, cameline oil, evening primrose oil and borage oil, the vegetable oils being present in a proportion such as to provide an omega-3 to omega-6 ratio within said composition of between 1 and 5, (ii) at least one mineral, preferably in salt form, selected from the group consisting of sodium, calcium and magnesium, preferably magnesium, (iii) at least one trace element selected from the group consisting of zinc, copper and iron, preferably from the group consisting of zinc and copper, (iv) at least vitamin C or derivative thereof, and (v) at least one essential oil, which has anti-free-radical properties, for performing a deep-down treatment which stimulates the microcirculation and the production of energy for the purpose of imparting dynamism to the cells and accelerating their renewal, protecting the collagen, and combating pigmentation spots.

Priority: FR20060005953 Applic. Date: 2006-06-30; WO2007FR01115 Applic. Date: 2007-07-02

Inventor: PIERRISNARD JEAN-LOUIS [FR]; MILLOU YVES [FR]; FONTES KATIA [FR]; TOUREL CECILE [FR]


Application No.: US20090269424A1  Published: 29/Oct/2009

Title: Peripheral blood flow-improving composition

Applicant/Assignee: SUNTORY HOLDINGS LIMITED

Application No.: 12/458157   Filing Date: 01/Jul/2009

Abstract:The present invention provides a composition that can effectively improve peripheral blood flow to thereby ameliorate cold sensation, numbness, pains and other skin symptoms, as well as frostbites, chilblains and chaps and other skin disorders associated with disturbed peripheral blood flow. This composition has no side effects. Specifically, the peripheral blood flow-improving composition contains, as an active ingredient, a extract of a plant of the genus Lepidium of the family Cruciferae. More specifically, the composition contains as an active ingredient a extract of maca plant (Lepidium meyenii Walp). Food and beverage products, perfumes and cosmetics, and pharmaceutical products containing the peripheral blood flow-improving composition are also provided.

Priority: JP20040101735 Applic. Date: 2004-03-31; US2007-594905 Applic. Date: 2007-08-01; WO2005JP06325 Applic. Date: 2005-03-31

Inventor: KODA HIROFUMI [JP]; KISO YOSHINOBY [JP]; MATSUMOTO TAKEHIRO [JP]


Application No.: US20090269427A1  Published: 29/Oct/2009

Title: HERBAL COMPOSITION FOR INFLAMMATORY DISORDERS

Applicant/Assignee: PIRAMAL LIFE SCIENCES LIMITED

Application No.: 12/500057   Filing Date: 09/Jul/2009

Abstract:This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-alpha) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti-inflammatory agent.

Priority: IN2005MU01226 Applic. Date: 2005-09-30; US2008-079853 Applic. Date: 2008-03-28; WO2006IB53540 Applic. Date: 2006-09-28; US20050736443P Applic. Date: 2005-11-14

Inventor: CHAUHAN VIJAY [IN]; SUTHAR ASHISH [IN]; SAPRE DHANANJAY [IN]; BAL-TEMBE SWATI [IN]; GANGOPADHYAY ASHOK KUMAR [IN]; KULKARNI-ALMEIDA ASHA [IN]; PARIKH SAPNA HASIT [IN]; GUPTE RAVINDRA DATTATRAYA [IN]; DAGIA NILESH MADHUKAR [IN]; SHARMA SOMESH [IN]; DADARKAR SHRUTA SUDHEER [IN]; JADHAV MAHESH GUNDAJI [IN]; TANNU ADITI AMOL [IN]


Application No.: US20090270402A1  Published: 29/Oct/2009

Title: Novel triazolopyridazines

Applicant/Assignee:

Application No.: 12/215338   Filing Date: 26/Jun/2008

Abstract:The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Priority: US20070937607P Applic. Date: 2007-06-28

Inventor: CALDERWOOD DAVID J [US]; BONAFOUX DOMINIQUE F [US]; BURCHAT ANDREW [US]; DING PING [US]; FRANK KRISTINE E [US]; HOEMANN MICHAEL Z [US]; MULLEN KELLY D [US]; DAVIS HEATHER M [US]


Application No.: US20090270442A1  Published: 29/Oct/2009

Title: POLYMORPHS OF HYDROCHLORIDE SALT OF 5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B]INDOLE-7-CARBOXAMIDE AND METHODS OF USE THEREFOR

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 12/422877   Filing Date: 13/Apr/2009

Abstract:Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat various diseases.

Priority: US20080045523P Applic. Date: 2008-04-16

Inventor: GRAHAM LAUREN [US]; ISBESTER PAUL [US]; LAPINA OLGA V [US]; MOBELE BINGIDIMI I [US]; PALMER GRANT J [US]; REINEKE KARL [US]; SALSBURY JONATHON S [US]; ULYSSE LUCKNER [US]


Application No.: US20090274637A1  Published: 05/Nov/2009

Title: Depigmenting or Brigthening Cosmetic Composition at Least One Oxazolin as an Active Ingredient

Applicant/Assignee:

Application No.: 11/919253   Filing Date: 27/Apr/2006

Abstract:The invention relates to the cosmetic use of at least one oxazolin as a depigmenting active ingredient in a depigmenting composition, and to the associated cosmetic treatment method. The invention also relates to the use of at least one oxazolin for preparing an active medicament as a depigmenting agent, and to a depigmenting cosmetic composition comprising at least one oxazolin as a depigmenting active ingredient.

Priority: WO2006EP61902 Applic. Date: 2006-04-27; FR20050004227 Applic. Date: 2005-04-27

Inventor: MSIKA PHILIPPE [FR]; PICCARDI NATHALIE [FR]


Application No.: US20090274638A1  Published: 05/Nov/2009

Title: COSMETIC USE OF A C-GLYCOSIDE DERIVATIVE IN COMBINATION WITH ASCORBIC ACID

Applicant/Assignee: L'OREAL

Application No.: 12/306566   Filing Date: 03/Jul/2007

Abstract:The present invention relates to a cosmetic use of a synergistic combination of at least one C-glycoside derivative with at least ascorbic acid, or one of its derivatives or analogs, for preventively or curatively treating the signs of aging of body or facial skin, irrespective of whether they are chronobiological or photoinduced.

Priority: FR20060006027 Applic. Date: 2006-07-03; US20060832941P Applic. Date: 2006-07-25; WO2007FR51587 Applic. Date: 2007-07-03

Inventor: PINEAU NATHALIE [FR]; CATROUX PHILIPPE [FR]


Application No.: US20090274677A1  Published: 05/Nov/2009

Title: ANTIOXIDANT FOR USE IN COSMETIC, MEDICATED AND PHARMACEUTICAL PREPARATIONS

Applicant/Assignee:

Application No.: 12/434409   Filing Date: 01/May/2009

Abstract:The invention provides the use a 2,2-dimethyl chroman as a SOD mimetic in a cosmetic preparation. Cosmetic preparations comprising a 2,2-dimethyl chroman as a SOD mimetic are described, as well as methods for treating or preventing free radical damage to skin cells and treating or preventing hair loss which comprise topical administration of a 2,2-dimethyl chroman as a SOD mimetic.

Priority: EP20080155616 Applic. Date: 2008-05-02

Inventor: ISAACS ELLIOT JAMES [GB]; GREGORY EMMA [GB]


Application No.: US20090274752A1  Published: 05/Nov/2009

Title: COSMETIC AND DERMATOLOGICAL FORMULATIONS OF MNTF PEPTIDES

Applicant/Assignee: DERMACARE NEUROSCIENCES INSTITUTE

Application No.: 12/391243   Filing Date: 23/Feb/2009

Abstract:The disclosure is directed to methods and compositions that include MNTF peptides and their analogs for cosmetic and dermatological purposes.

Priority: US20080066670P Applic. Date: 2008-02-21

Inventor: KO PUI-YUK DOROTHY [US]


Application No.: US20090274760A1  Published: 05/Nov/2009

Title: Use of An Alkyl Glycoside Or Of A Mixture Of Alkyl Glycosides Having Anti-Ageing And/Or Calming Properties As Active Agents In Cosmetic Compositions, And Methods Of Cosmetic Care Using Said Compositions

Applicant/Assignee: LVMH RECHERCHE UNIVERSITE DE PICARDIE JULES VERNE

Application No.: 12/415058   Filing Date: 31/Mar/2009

Abstract:The present invention relates to a novel use of alkyl glycosides and of mixtures of alkyl glycosides having anti-ageing and/or calming properties as active agents in cosmetic compositions, and to methods of cosmetic care using the said compositions.

Priority: FR20080052193 Applic. Date: 2008-04-02

Inventor: THIEBAULT NICOLAS [FR]; ARCHAMBAULT JEAN-CHRISTOPHE [FR]; ANDRE PATRICE [FR]; PILARD FLORENCE [FR]; MOREAU VINCENT [FR]


Application No.: US20090274770A1  Published: 05/Nov/2009

Title: CELLULAR EXTRACTS

Applicant/Assignee: REGENICS AS

Application No.: 12/437100   Filing Date: 07/May/2009

Abstract:The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. This invention relates to the use of cells and cellular extracts in rejuvenation and healing technologies thereby improving healing and regeneration of all bodily tissues and organs. The present invention relates to compositions and methods of managing, preventing, and treating scars. The invention also relates to prevention of deterioration, damage and malfunction of cells and tissues, and to promote, improve or exceed cellular function in order to promote, improve and exceed appearance, vitality and health. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

Priority: US2007-801778 Applic. Date: 2007-05-11; US20080051931P Applic. Date: 2008-05-09; US20080120146P Applic. Date: 2008-12-05; US20060799560P Applic. Date: 2006-05-11

Inventor: GAMMELSAETER RUNHILD [NO]; REMMEREIT JAN [NO]


Application No.: US20090275515A1  Published: 05/Nov/2009

Title: 2-HYDROXY-2-PHENYLTHIOPHENYLPROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS

Applicant/Assignee:

Application No.: 12/442581   Filing Date: 15/Oct/2007

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HFV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20060852594P Applic. Date: 2006-10-18; WO2007US21984 Applic. Date: 2007-10-15

Inventor: KIM YUNTAE [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]; PERKINS JAMES J [US]; ROSSI MICHAEL A [US]; WANG JIABING [US]


Application No.: US20090275525A1  Published: 05/Nov/2009

Title: USE OF A LACTOSE-DERIVED C-GLYCOSIDE COMPOUND AS AN AGENT FOR ACTIVATING AND REGULATING CUTANEOUS IMMUNITY

Applicant/Assignee: L'OREAL

Application No.: 12/296304   Filing Date: 05/Apr/2007

Abstract:The present invention relates to novel lactose-derived compounds of general formula (I) and to their use as agents for stimulating the immune system of the skin and/or as immunoregulators, and for preparing a composition containing a cosmetically or pharmaceutically acceptable medium, intended in particular to prevent and/or limit the appearance of cutaneous immune imbalances, in particular related to environmental stresses.

Priority: WO2007EP53364 Applic. Date: 2007-04-05; FR20060051268 Applic. Date: 2006-04-07; US20060797387P Applic. Date: 2006-05-04

Inventor: PINEAU NATHALIE [FR]; DALKO MARIA [FR]


Application No.: US20090275527A1  Published: 05/Nov/2009

Title: SKIN AGING TREATMENT COMPRISING PAEONIFLORIN

Applicant/Assignee: LG HOUSEHOLD & HEALTH CARE LTD

Application No.: 12/502769   Filing Date: 14/Jul/2009

Abstract:The present invention relates to a skin aging treatment comprising paeoniflorin as an active ingredient. Since paeoniflorin is effective in significantly inhibiting and improving intrinsic skin aging, significantly inhibiting and improving DNA impairment and skin wrinkling caused by UV and improving existing wrinkles, a cosmetic composition and a pharmaceutical composition comprising paeoniflorin may become a very useful skin aging treatments.

Priority: KR20040032641 Applic. Date: 2004-05-10; KR20050018589 Applic. Date: 2005-03-07; KR20050035482 Applic. Date: 2005-04-28; US2007-571906 Applic. Date: 2007-01-10; WO2005KR01310 Applic. Date: 2005-05-10

Inventor: PARK HYOUNG-KOOK [KR]; LIM JUN-MAN [KR]; LEE SANG-HWA [KR]; KANG SANG-JIN [KR]; CHO WAN-GOO [KR]


Application No.: US20090280069A1  Published: 12/Nov/2009

Title: PROGUANIL TO TREAT SKIN/MUCOSAL DISEASES

Applicant/Assignee: TOLMAR, INC

Application No.: 12/463028   Filing Date: 08/May/2009

Abstract:Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro-organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes, a bacteria that causes acne

Corynebacterium minutissimum, a bacteria that causes erythrasma, Gardnerella vaginalis, a bacteria that causes vaginosis

Trichomonas vaginalis, a protozoan that causes trichomoniasis and C. albicans, a fungus (a form of yeast).

Priority: US20080051812P Applic. Date: 2008-05-09

Inventor: GODOWSKI KENNETH C [US]


Application No.: US20090280071A1  Published: 12/Nov/2009

Title: USE OF REPEAT SEQUENCE PROTEIN POLYMERS IN PERSONAL CARE COMPOSITIONS

Applicant/Assignee:

Application No.: 11/860911   Filing Date: 25/Sep/2007

Abstract:A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.

Priority: US2004-800179 Applic. Date: 2004-03-12

Inventor: KUMAR MANOJ [US]; CUEVAS WILLIAM A [US]


Application No.: US20090280078A1  Published: 12/Nov/2009

Title: Cosmetic composition to accelerate repair of functional wrinkles

Applicant/Assignee:

Application No.: 12/460505   Filing Date: 20/Jul/2009

Abstract:A cosmetic composition consists of a combination of peptides that regenerate the dermal matrix and a rapid acting muscle relaxant derived from the extract of the plant, Acmella oleracea. By limiting cutaneous deformation caused by the contraction of facial muscles the extract increases the efficiency of the peptides in reducing expression lines.

Priority: US2006-504119 Applic. Date: 2006-08-15; US20050713454P Applic. Date: 2005-09-01

Inventor: BELFER WILLIAM A [US]


Application No.: US20090280079A1  Published: 12/Nov/2009

Title: COMPOSITION AND USES THEREOF

Applicant/Assignee: THE BOOTS COMPANY PLC

Application No.: 12/297067   Filing Date: 13/Apr/2007

Abstract:Use of a composition comprising oil bodies in the preparation of a formulation for administration to a mammal wherein said composition comprises oil curd 5 extracted from grain plant tissue, said oil curd comprising an aqueous dispersion of oil bodies and associated extrinsic protein material. Preferably, the oil curd is extracted from oat seed material. The composition has useful properties in improving the stability of 10 formulations, in particular in emulsifying such formulations and in improving the aesthetic acceptability of a formulation. Also, the compositions are useful in the delivery of actives into the skin &/or hair and in the regulation of the condition of the skin &/or hair. 15 Processes for the preparation of said composition and formulations are also disclosed.

Priority: GB20060007475 Applic. Date: 2006-04-13; GB20070001711 Applic. Date: 2007-01-30; US20070898407P Applic. Date: 2007-01-31; WO2007GB50193 Applic. Date: 2007-04-13

Inventor: GRAY DAVID ALISTAIR [GB]; LONG STEWART PAUL [GB]; WHITE DANIEL ALLAN [GB]; PALIN JANET [GB]; GALLEY EDWARD [GB]


Application No.: US20090280148A1  Published: 12/Nov/2009

Title: CASEIN NANOPARTICLE

Applicant/Assignee:

Application No.: 12/295287   Filing Date: 29/Mar/2007

Abstract:An object of the present invention to provide: a nanoparticle, which can be produced without the use of surfactants and synthetic polymers, which has a controllable size and is stable in the acidic range, and which further contains an active substance

and a method for producing the same. The present invention provides a casein nanoparticle which contains an active substance and has an average particle size between 10 nm or more and less than 300 nm, which is produced by the following steps (a) to (c): (a) a step of mixing casein into a basic aqueous medium between pH 8 or more and less than pH 11

(b) a step of adding at least one type of active substance to the solution obtained in the step (a)

and (c) a step of injecting the solution obtained in the step (b) into an acidic aqueous medium at pH 3.5 to pH 7.5.

Priority: JP20060090205 Applic. Date: 2006-03-29; WO2007JP56893 Applic. Date: 2007-03-29

Inventor: AIMI MAKIKO [JP]; NEMORI RYOICHI [JP]; OGIWARA KAZUTAKA [JP]


Application No.: US20090280150A1  Published: 12/Nov/2009

Title: Targeted And Individualized Cosmetic Delivery

Applicant/Assignee:

Application No.: 12/410118   Filing Date: 24/Mar/2009

Abstract:A system and methods are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolated, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user. Targeted delivery of one or multiple skin benefit agents to the skin of a user may be achieved by applying and conforming to the skin a flexible cosmetic delivery sheet having associated therewith, on a first surface, one or multiple cosmetic treatment compositions provided in isolated, discrete regions, while an opposite surface of the sheet is provided with imprinted, predetermined regions corresponding to respective isolated, discrete regions on the first surface of the sheet. The user manipulates the sheet at the imprinted predetermined regions in a manner indicated by the imprinted predetermined regions to release one or multiple skin treatment compositions from the isolated, discrete regions and deliver effective amounts of one or multiple skin benefit agents to the targeted areas of the skin underlying the isolated, discrete regions of the sheet.

Priority: US20080051774P Applic. Date: 2008-05-09; US20080097273P Applic. Date: 2008-09-16

Inventor: KAMEN TAMAR LARA [US]; MOHAMMADI FATEMEH [US]; QU LISA [US]; CZARNOTA ANNA [US]; MOU TSUNG-WEI ROBERT [US]


Application No.: US20090280167A1  Published: 12/Nov/2009

Title: ENHANCEMENT OF DRUG THERAPY BY MIRNA

Applicant/Assignee: ABRAXIS BIOSCIENCE, LLC

Application No.: 12/436937   Filing Date: 07/May/2009

Abstract:This invention provides methods and compositions for screening of microRNA capable of modulating gene expression in the apoptotic pathway in the presence of HSP90 inhibitor. The use of miRNA for enhancing the activity of therapeutic agents not limited to HSP90 inhibitor is also disclosed. The diagnostic use of miRNA for predicting response to therapy not limited to therapeutic agents is also disclosed. A method for the identification and therapeutic application of small molecules which are modulators of these nucleic acids are also included in this application

Priority: US20080051309P Applic. Date: 2008-05-07

Inventor: TRIEU VUONG [US]; HWANG LARN [US]; DESAI NEIL [US]


Application No.: US20090280503A1  Published: 12/Nov/2009

Title: Method for detecting and treating skin disorders

Applicant/Assignee:

Application No.: 12/310956   Filing Date: 14/Sep/2007

Abstract:The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition binds to the exposed cell surface antigen (epitope) and allows the detection and/or disrupts the growth of the diseased tissue. In addition, this invention provides methods of treating psoriasis, scleroderma, eczema or atopic dermatitis by eliciting an immune response in an individual against an antigen which is only exposed to antibody detection in tissues affected by these disorders

Priority: US20060845099P Applic. Date: 2006-09-15; WO2007US19988 Applic. Date: 2007-09-14

Inventor: FIORE JAMES [US]


Application No.: US20090281011A1  Published: 12/Nov/2009

Title: Solid Textile Care And/Or Skincare Composition

Applicant/Assignee: HENKEL AG & CO. KGAA

Application No.: 12/465759   Filing Date: 14/May/2009

Abstract:Solid textile- and/or skin-care compositions encompassing a water-soluble particle and a water-insoluble particle that contains a water-insoluble carrier and a textile- and/or skin-care compound. Also, textile-softening washing detergents or cleaning agents encompassing the textile- and/or skin-care composition.

Priority: DE200610054436 Applic. Date: 2006-11-16; WO2007EP60812 Applic. Date: 2007-10-11

Inventor: MAYER KONSTANZE [DE]; SCHEFFLER KARL-HEINZ [DE]; ARTIGA GONZALEZ RENE-ANDRES [DE]; STURM MARIO [DE]


Application No.: US20090281158A1  Published: 12/Nov/2009

Title: PRODRUGS OF CC-1065 ANALOGS

Applicant/Assignee: IMMUNOGEN, INC

Application No.: 12/505175   Filing Date: 17/Jul/2009

Abstract:Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described

such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytoxic drugs in a targeted fashion.

Priority: US2007-649822 Applic. Date: 2007-01-05; US2005-217351 Applic. Date: 2005-09-02; US2003-692856 Applic. Date: 2003-10-27; US2002-116053 Applic. Date: 2002-04-05

Inventor: ZHAO ROBERT YONGXIN [US]; CHARI RAVI V J [US]


Application No.: US20090281188A1  Published: 12/Nov/2009

Title: ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/437008   Filing Date: 07/May/2009

Abstract:Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.

Priority: FR20020003070 Applic. Date: 2002-03-12; US2004-937612 Applic. Date: 2004-09-10; WO2003EP03246 Applic. Date: 2003-03-12; US20020370223P Applic. Date: 2002-04-08

Inventor: GRAEBER MICHAEL [US]; CZERNIELEWSKI JANUSZ [FR]


Application No.: US20090284691A1  Published: 19/Nov/2009

Title: Electronic skin having uniform gray scale reflectivity

Applicant/Assignee:

Application No.: 12/152862   Filing Date: 16/May/2008

Abstract:The invention features electronic skin including an active layer formed of bistable cholesteric liquid crystal material and articles comprising the skin, the electronic skin having uniform gray scale reflectivity. Also featured is method for producing suitable reduction pulses that will provide a display (e.g., the electronic skin) with uniform gray scale reflectivity. Reduction pulses of narrow width are used to create uniform levels of gray in the electronic skin to overcome display imperfections that cause discontinuity in the gray scale reflectivity.

Priority:

Inventor: MARHEFKA DUANE W [US]; VENKATARAMAN NITHYA [US]; BARUA SANKAR [US]


Application No.: US20090285768A1  Published: 19/Nov/2009

Title: Compositions and Methods Incorporating Photocatalysts

Applicant/Assignee:

Application No.: 12/433958   Filing Date: 01/May/2009

Abstract:The various embodiments provide a composition including an active material having functional groups capable of covalent attachment to a substrate in the presence of an acid or a base, a photocatalyst capable of generating an acid or a base upon exposure to light, and a vehicle. The compositions may also include surfactants, emulsifiers, oxidants, and other components. A method for treating a substrate is also disclosed. The method includes the steps of applying at least one active material having functional groups to the substrate, applying a photocatalyst to the substrate, and exposing the photocatalyst and the at least one active material to light for forming covalent attachments between the functional groups and constituent groups on the substrate. The compositions and methods described herein are useful in personal care product and consumer care product applications, for example.

Priority: US20080053831P Applic. Date: 2008-05-16

Inventor: BAKER ELLEN SCHMIDT [US]; CONSTANTINIDES IOANNIS CONSTANTINE [US]; DUNBAR JAMES CHARLES [US]; FELTS TIMOTHY JAMES [US]; MUELLER WILLIAM RICHARD [US]; MURPHY BRYAN PATRICK [US]; WILEY ALAN DAVID [US]


Application No.: US20090285785A1  Published: 19/Nov/2009

Title: External Agent for Treatment of Skin Ulcer

Applicant/Assignee: CELLGENTECH, INC

Application No.: 11/663072   Filing Date: 16/Sep/2005

Abstract:[Problems] To provide a novel external agent for treatment of skin ulcer which has an excellent healing effect on intractable skin ulcer such as bedsore, diabetic skin ulcer and ischemic skin ulcer. [Means for Solving Problems] The agent is characterized in that it comprises a composition containing at least one selected from the group consisting of granulocyte colony stimulating factor (G-CSF), stromal cell-derived factor-1 (SDF-1) and CD41-positive cells, and a hydrophilic high molecular substance.

Priority: JP20040271996 Applic. Date: 2004-09-17; JP20050140301 Applic. Date: 2005-05-12; JP20050239189 Applic. Date: 2005-08-19; WO2005JP17121 Applic. Date: 2005-09-16

Inventor: JIMI SHIRO [JP]; SUZUMIYA JUNJI [JP]; SATO TOMOHITO [JP]


Application No.: US20090285833A1  Published: 19/Nov/2009

Title: CLOSTRIDIUM BOTULINUM C3 EXOTRANSFERASE COMPOSITIONS AND METHODS FOR TREATING TUMOUR SPREADING

Applicant/Assignee: BIOAXONE THERAPEUTIQUE INC

Application No.: 12/402352   Filing Date: 11/Mar/2009

Abstract:Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a cancer in a mammal. The compositions can each effect or arrest combination of two or more of tumor cell proliferation, migration, angiogenesis, and metalloproteinase secretion.

Priority: US2006-573658 Applic. Date: 2006-11-07; WO2004CA01763 Applic. Date: 2004-09-29; US20030506162P Applic. Date: 2003-09-29; US2004-902878 Applic. Date: 2004-08-02

Inventor: MCKERRACHER LISA [CA]; LASKO DANA [CA]


Application No.: US20090285838A1  Published: 19/Nov/2009

Title: USE OF SOLUBLE CD164 IN INFLAMMATION AND AUTOIMMUNE DISORDERS

Applicant/Assignee: LABORATOIRES SERONO SA

Application No.: 12/341490   Filing Date: 22/Dec/2008

Abstract:The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.

Priority: EP20030077316 Applic. Date: 2003-07-23; US2004-565741 Applic. Date: 2004-07-23; WO2004EP51596 Applic. Date: 2004-07-23

Inventor: CHVATCHKO YOLANDE [CH]


Application No.: US20090285866A1  Published: 19/Nov/2009

Title: Self-healing polymer compositions

Applicant/Assignee:

Application No.: 12/119623   Filing Date: 13/May/2008

Abstract:A composition including a film-former and a porous polymeric release system comprising a solvent for the film-former is provided. Also provided is a method of prolonging the physical stability of a film-former on the skin by applying to the skin a self-healing composition containing the film-former and a porous polymeric release system comprising a solvent for the film-former.

Priority:

Inventor: AFRIAT ISABELLE R [US]; SOJKA MILAN F [US]; CUMMINS PHILLIP [US]; GIACOMONI PAOLO U [US]


Application No.: US20090285868A1  Published: 19/Nov/2009

Title: Photostable cosmetic compositions comprising dibenzoylmethane/pyrrolidinone compounds

Applicant/Assignee: L'OREAL

Application No.: 12/453537   Filing Date: 14/May/2009

Abstract:Photostable UV-photoprotecting cosmetic sunscreen compositions contain (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane compound sunscreen, (b) an effective radiation-photostablizing amount of at least one pyrrolidinone compound having the formula (I) below: and, advantageously, at least one liquid fatty phase and at least one lipophilic active sunscreen agent of low solubility, formulated into (c) a cosmetically acceptable support therefor.

Priority: FR20080053103 Applic. Date: 2008-05-14; US20080055847P Applic. Date: 2008-05-23

Inventor: RICHARD HERVE [FR]; ROZOT ROGER [FR]


Application No.: US20090285875A1  Published: 19/Nov/2009

Title: Infused Sponge Delivery System

Applicant/Assignee:

Application No.: 12/308108   Filing Date: 08/Jun/2007

Abstract:A method for delivering active ingredients to a wet substrate from a flexible, three-dimensional, water-absorbent substrate material comprised of a web of substantially water-insoluble fibers into which is infused a solid anhydrous composition having a melting point of from about 45 DEG C. to about 55 DEG C. said anhydrous composition comprising (i) at least one surfactant selected from the group consisting of cationic quaternary surfactants, anionic surfactants or nonionic surfactants or one multi-lamellar liquid crystal emulsifier system, (ii) at least one fatty alcohol, (iii) at least one emollient selected from the group consisting of cosmetically-acceptable oils, esters and liquid triglycerides, (iv) at least one active ingredient and (v) optionally, a solid cleansing agent having a melting point from about 50 DEG C. to about 70 DEG C. Preferred active ingredients are skincare and haircare actives, including emollients, humectants, conditioning agents, sunscreens and sunblocks, and artificial tanning agents.

Priority: US20060812578P Applic. Date: 2006-06-08; WO2007US13478 Applic. Date: 2007-06-08

Inventor: POPOVSKY MICHAEL [US]; POPOVSKY YELENA [US]; THAU PAUL [US]


Application No.: US20090286769A1  Published: 19/Nov/2009

Title: COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 12/535513   Filing Date: 04/Aug/2009

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2007-967423 Applic. Date: 2007-12-31; US2005-138097 Applic. Date: 2005-05-26; US2001-774557 Applic. Date: 2001-01-31; US20000193645P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL ANTHONY [US]; MCIVER JOHN MCMILLAN [US]; YOUNGQUIST ROBERT SCOTT [US]


Application No.: US20090286780A1  Published: 19/Nov/2009

Title: 2-OXOCHROMENE DERIVATIVES

Applicant/Assignee: KOWA COMPANY, LTD

Application No.: 12/394548   Filing Date: 27/Feb/2009

Abstract:To provide a novel LXRbeta agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis

arteriosclerosis such as those resulting from diabetes

dyslipidemia

hypercholesterolemia

lipid-related diseases

inflammatory diseases that are caused by inflammatory cytokines

skin diseases such as allergic skin diseases

diabetes

or Alzheimer's disease. [Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

Priority: US20080032651P Applic. Date: 2008-02-29

Inventor: OKUDA AYUMU [JP]; MATSUDA TAKAYUKI [JP]; MIURA TORU [JP]; OZAWA HIDEFUMI [JP]; TOSAKA AYAKO [JP]; YAMAZAKI KOICHI [JP]; YAMAGUCHI YUKI [JP]; KUROBUCHI SAYAKA [JP]; WATANABE YUUICHIROU [JP]; SHIBUYA KIMIYUKI [JP]


Application No.: US20090286874A1  Published: 19/Nov/2009

Title: Anti-aging composition containing phloretin

Applicant/Assignee: L'OREAL

Application No.: 12/386224   Filing Date: 15/Apr/2009

Abstract:An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives

(b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives

and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.

Priority: US2007-726176 Applic. Date: 2007-03-20; US20060784571P Applic. Date: 2006-03-22

Inventor: PINNELL SHELDON R [US]; ZIELINSKI JAN [US]; HANSENNE ISABELLE [US]


Application No.: US20090287168A1  Published: 19/Nov/2009

Title: METHOD OF DELIVERING A SKIN BENEFIT

Applicant/Assignee: WYETH

Application No.: 12/465333   Filing Date: 13/May/2009

Abstract:A method of providing a skin benefit to the skin including the use of a skin care active and a portable moist heat delivery system comprising: a water vapor generating portion comprising a water vapor source and a heat source

and a water vapor-air regulating portion located at a skin-facing side of the water vapor generating portion, the water vapor-air regulating portion comprising a water vapor-air mixing layer, a water vapor-air distribution layer, a latent heat delivery surface, and optionally a skin contact layer, where the water vapor generating portion and the water vapor-air regulating portion are in fluid communication is disclosed.

Priority: US20080093049P Applic. Date: 2008-08-29; US20080093009P Applic. Date: 2008-08-29; US20080053480P Applic. Date: 2008-05-15

Inventor: MITRA SHEKHAR [US]; ZIMMEMAN DEAN A [US]; WONG VINCENT YORK-LEUNG [US]; BELKIN MARINA [US]


Application No.: US20090287280A1  Published: 19/Nov/2009

Title: Portable moist heat system

Applicant/Assignee: WYETH

Application No.: 12/454129   Filing Date: 13/May/2009

Abstract:A portable moist heat delivery system comprising a water vapor generating portion comprising a water vapor source and a heat source

a water vapor-air regulating portion, said water vapor-air regulating portion comprising a water vapor-air mixing layer, and a water vapor-air distribution layer

said water vapor generating portion and said water vapor-air regulating portion being in fluid communication

and said water vapor-air regulating portion having a latent heat delivery surface disposed adjacent said water vapor-air regulating portion which delivers moist heat at a preselected temperature range wherein about 15% to about 95% of the moist heat is latent heat of condensation. Methods include delivering improved pain relief, blood flow, relaxation, and reduced cardiac workload.

Priority: US20080053480P Applic. Date: 2008-05-15; US20080093009P Applic. Date: 2008-08-29

Inventor: WONG VINCENT YORK-LEUNG [US]; BELKIN MARINA [US]; HICKSON CHAD KAMIL [US]; OWENS JR LEROY GLENN [US]


Application No.: US20090288176A1  Published: 19/Nov/2009

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC

Application No.: 11/814025   Filing Date: 18/Apr/2007

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20060793331P Applic. Date: 2006-04-19; WO2007US66886 Applic. Date: 2007-04-18

Inventor: BOLLINGER KRISTI RAE [US]; DE SAUVAGE FREDERIC J [US]; EDWARDS JOEL [US]; GIRGIS ROSEMARY [US]; GREEN LESLIE JANE [US]; MINZE LAURIE JEANETTE [US]; PAYNE BOBBY JOE [US]; RANGEL CAROLINA [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; TANG TRACY TZU-LING [US]; VOGEL PETER [US]


Application No.: US20090291051A1  Published: 26/Nov/2009

Title: COMPOSITIONS HAVING A HEATING EFFECT

Applicant/Assignee: L'OREAL

Application No.: 12/423220   Filing Date: 14/Apr/2009

Abstract:A method, including applying to a keratin substance a layer of a composition containing, in an anhydrous medium, at least one exothermic metal salt, and, optionally, one or more of the following: a layer of a composition containing a monocarbonylated or polycarbonylated self-tanning agent

a layer of a shaving composition and/or a depilatory composition

a layer of a composition containing a dye, a pigment, or both

and a layer of a composition containing an active ingredient.

Priority: US20080047778P Applic. Date: 2008-04-25

Inventor: SENEE JEROME [FR]; COMPAIN DELPHINE [FR]


Application No.: US20090291053A1  Published: 26/Nov/2009

Title: LOW MOLECULAR WEIGHT AMPHOLYTIC POLYMERS FOR PERSONAL CARE APPLICATIONS

Applicant/Assignee:

Application No.: 12/534221   Filing Date: 03/Aug/2009

Abstract:A cosmetically acceptable composition comprising from about 0.1 to about 10 weight percent, based on polymer solids, of a water-soluble ampholyte polymer comprising: from at least 1 to as much as 95 weight percent of the nonionic monomer acrylamide

from at least 5 to as much as 80 weight percent of the cationic monomer dimethyldiallylammonium chloride

from at least 1 to as much as 75 weight percent of the anionic monomer acrylic acid, is disclosed. The application of these polymers to a keratinous substance is also disclosed. In addition, a method of treating a keratinous substance comprising applying a cosmetically acceptable composition comprising from about 0.1 to about 10 weight percent, based on polymer solids, of an ampholyte polymer produced by the following process: (1) preparing a monomer solution containing: from at least 1 to as much as 95 weight percent of the nonionic monomer acrylamide

from at least 5 to as much as 80 weight percent of the cationic monomer dimethyldiallylammonium chloride

from at least 1 to as much as 75 weight percent of the anionic monomer acrylic acid

(2) providing a reactor and water to said reactor

(3) optionally charging said reactor with a sequestering agent, a chain transfer agent or a combination thereof

(3) purging said reactor to remove oxygen from said reactor

(4) heating the contents of said reactor

and (5) feeding said monomer solution and initiator solution into said reactor, is disclosed.

Priority: US2006-369044 Applic. Date: 2006-03-06

Inventor: SABELKO JOBIAH J [US]; CRAMM JEFFREY R [US]; PATEL DAMYANTI J [US]


Application No.: US20090291057A1  Published: 26/Nov/2009

Title: ANIMAL CARE COMPOSITION

Applicant/Assignee:

Application No.: 12/466409   Filing Date: 15/May/2009

Abstract:Methods of cleansing, conditioning and optionally therapeutically treating skin, hair, and/or other keratinous surfaces of a companion animal are provided. The method includes: contacting the skin, hair, and/or other keratinous surfaces of a companion animal with a companion animal care composition, the composition having a cleansing component, and a conditioning component

and optionally rinsing the skin, hair, and/or other keratinous surfaces of the companion animal with water

wherein after use of the composition, the composition provides a friction coefficient of from about 0.65 to about 0.8. Also included are articles of commerce having a container containing a companion animal care composition, which composition provides cleansing, conditioning, and optional treatment benefits to a companion animal. The container has instructions for cleansing, conditioning, and optionally treating the companion animal. Also included are companion animal care compositions having a cleansing component and a conditioning component, wherein after use of the composition, the composition provides a friction coefficient of from about 0.65 to about 0.8.

Priority: US20080054834P Applic. Date: 2008-05-21

Inventor: CHANG DEBORA W [US]; CAUDILL SHELLIE JEAN PORTER [US]


Application No.: US20090291148A1  Published: 26/Nov/2009

Title: Depilatory Kit Resulting in Reduced Odor and Irritation

Applicant/Assignee:

Application No.: 12/338215   Filing Date: 18/Dec/2008

Abstract:A depilatory kit may comprise a depilatory composition comprising a sulfur-containing depilatory agent and a finishing composition comprising a metal oxide selected from the group consisting of zinc oxide, aluminum oxide, and magnesium oxide. The depilatory composition may further comprise a lactone such as 1,15-cyclopentadecanolide. Methods for using the depilatory kits are also disclosed herein.

Priority: US20070015953P Applic. Date: 2007-12-21

Inventor: BREYFOGLE LAURIE ELLEN [US]; ZUKOWSKI JOSEPH MICHAEL [US]; ELSBROCK ROBERT JOHN [US]


Application No.: US20090291155A1  Published: 26/Nov/2009

Title: Herbal Composition

Applicant/Assignee: PIRAMAL LIFE SCIENCES LIMITED

Application No.: 12/087704   Filing Date: 05/Jan/2007

Abstract:The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.

Priority: US20060758593P Applic. Date: 2006-01-12; WO2007IB50031 Applic. Date: 2007-01-05

Inventor: CHAUHAN VIJAY [IN]; SHANMUGANATHAN MUTHUSAMY VELUCHAMY [IN]


Application No.: US20090291900A1  Published: 26/Nov/2009

Title: METHODS FOR TREATMENT OF HEADACHES BY ADMINISTRATION OF OXYTOCIN

Applicant/Assignee:

Application No.: 12/409419   Filing Date: 23/Mar/2009

Abstract:The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.

Priority: US2008-210866 Applic. Date: 2008-09-15; US2006-511997 Applic. Date: 2006-08-28; US20050711950P Applic. Date: 2005-08-26; US20060794004P Applic. Date: 2006-04-21

Inventor: YEOMANS DAVID C [US]; ANGST MARTIN S [US]; FREY II WILLIAM H [US]; JACOBS DANIEL I [US]


Application No.: US20090291904A1  Published: 26/Nov/2009

Title: CHEMICAL DERIVATIVES OF JASMONATE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 12/095908   Filing Date: 07/Dec/2006

Abstract:The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.

Priority: US20050742875P Applic. Date: 2005-12-07; US20060772567P Applic. Date: 2006-02-13; WO2006IL01408 Applic. Date: 2006-12-07

Inventor: KASHMAN YOEL [IL]; FLESCHER ELIEZER [IL]; HERZBERG MAX [IL]


Application No.: US20090291938A1  Published: 26/Nov/2009

Title: POLO-LIKE KINASE INHIBITORS

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 12/274213   Filing Date: 19/Nov/2008

Abstract:Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20070989018P Applic. Date: 2007-11-19

Inventor: CAO SHELDON X [US]; FEHER VICTORIA [US]; ICHIKAWA TAKASHI [JP]; JONES BENJAMIN [US]; KALDOR STEPHEN W [US]; KIRYANOV ANDRE A [US]; LAM BETTY [US]; LIU YAN [US]; MCBRIDE CHRISTOPHER [US]; NATALA SRINIVASA REDDY [US]; NIE ZHE [US]; STAFFORD JEFFREY A [US]


Application No.: US20090291942A1  Published: 26/Nov/2009

Title: IMIDAZO PYRIDINE DERIVATIVES

Applicant/Assignee:

Application No.: 12/468706   Filing Date: 19/May/2009

Abstract:The invention relates to novel imidazopyridine derivatives and to their use in the treatment of diseases and disorders which may e.g. involve angiogenesis and/or pain, including autoimmune and inflammatory diseases.

Priority: EP20080156933 Applic. Date: 2008-05-26

Inventor: TARACIDO IVAN CORNELLA [US]; HARRINGTON EDMUND MARTIN [US]; HERSPERGER RENE [CH]; LATTMANN RENE [CH]; MILTZ WOLFGANG [CH]; WEIGAND KLAUS [CH]


Application No.: US20090293137A1  Published: 26/Nov/2009

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC

Application No.: 11/814413   Filing Date: 16/Nov/2006

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO 1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20050739105P Applic. Date: 2005-11-21; WO2006US60990 Applic. Date: 2006-11-16

Inventor: COMBS KATHERIN E [US]; DE SAUVAGE FREDERIC J [US]; FAN LIANGFEN [US]; FILVAROFF ELLEN [US]; HORNER ALLISON A B [US]; IRVING BRYAN [US]; JUNTULA JAGATH REDDY [US]; MASSEY ERIN MARIE [US]; MCLAIN DINA REBECCA [US]; MINZE LAURIE JEANETTE [US]; MONTGOMERY CHARLES [US]; PAYNE BOBBY JOE [US]; PHILIPS HEIDI [US]; RANGEL CAROLINA [US]; SEVAUX TRACY E W [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; STALA JOY ANNE [US]; TOWNSEND TERESA G [US]; VOGEL PETER [US]


Application No.: US20090297462A1  Published: 03/Dec/2009

Title: WATER-SOLUBLE POLYAMINOAMIDES AS SUNSCREEN AGENTS

Applicant/Assignee:

Application No.: 12/540420   Filing Date: 13/Aug/2009

Abstract:A UV-protective water-soluble polyaminoamide comprising UV-absorbing end groups, wherein the polyaminoamide absorbs ultraviolet light radiation having a wavelength of about 200 nm to about 420 nm, compositions comprising the UV-protective polyaminoamide and methods of treating substrates with the UV-protective polyaminoamide.

Priority: US2003-655163 Applic. Date: 2003-09-04

Inventor: HESSEFORT YIN [US]; WEI MINGLI [US]; CARLSON WAYNE [US]


Application No.: US20090297466A1  Published: 03/Dec/2009

Title: Continuous Moisturization Compositions

Applicant/Assignee:

Application No.: 12/467450   Filing Date: 18/May/2009

Abstract:An aqueous hair moisturizing composition is provided. The composition includes a cationic component, an oil containing about 70 percent or greater unsaturated fatty acids with chain length of C18 or greater, a phytosterol and a cellulosic polymer. Also provided is a method of imparting extended moisturization to the hair including the steps of applying to the hair in need of extended moisturization a composition including a cationic component, an oil containing about 70 percent or greater unsaturated fatty acids with chain length of C18 or greater, a phytosterol and a cellulosic polymer, and retaining the composition in contact with the hair for a time sufficient to impart extended moisturization to the hair.

Priority: US20080057243P Applic. Date: 2008-05-30

Inventor: GUTMANN ERIK [US]; MATRAVERS PETER [US]; FEALY BARBARA JEAN [US]; KEEN NATHAN [US]


Application No.: US20090297473A1  Published: 03/Dec/2009

Title: Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors

Applicant/Assignee: NYCOMED GMBH

Application No.: 11/992018   Filing Date: 08/Sep/2006

Abstract:Compounds of a certain formula 1, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Priority: EP20050108716 Applic. Date: 2005-09-21; WO2006EP66189 Applic. Date: 2006-09-08

Inventor: MAIER THOMAS [DE]; BECKERS THOMAS [DE]; HUMMEL ROLF-PETER [DE]; FETH MARTIN [DE]; MUELLER MATTHIAS [DE]; BAER THOMAS [DE]


Application No.: US20090297585A1  Published: 03/Dec/2009

Title: pH Modulated Films for Delivery of Actives

Applicant/Assignee:

Application No.: 12/130279   Filing Date: 30/May/2008

Abstract:pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water

and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.

Priority:

Inventor: MEYERS GARRY L [US]; PAULETTI GIOVANNI M [US]; DESAI KISHORKUMAR [US]


Application No.: US20090297591A1  Published: 03/Dec/2009

Title: Compositions And Methods For The Transdermal Delivery Of Pharmaceutical Compounds

Applicant/Assignee: ORIENT PHARMA CO., LTD

Application No.: 12/465923   Filing Date: 14/May/2009

Abstract:The present invention is directed to compositions and methods for the transdermal delivery of a pharmaceutically active compound. In some embodiments, the addition of inert pharmaceutical ingredients in place of a portion of adhesive in a transdermal patch formulation increases the rate of skin permeation of a pharmaceutical compound.

Priority: US20080129015P Applic. Date: 2008-05-30

Inventor: CHIANG CHIN-CHIH [US]; LIN TSE-CHING [TW]; CHEN REMY [TW]


Application No.: US20090297628A1  Published: 03/Dec/2009

Title: Use of iron in the form of a stone extract as stimulus of the synthesis of collagen by skin fibroblasts

Applicant/Assignee: GATTEFOSSE SAS

Application No.: 11/991398   Filing Date: 22/Sep/2006

Abstract:Use of a stone extract as stimulant of the synthesis of collagen by skin fibroblasts.

Priority: FR20050052851 Applic. Date: 2005-09-23; WO2006FR50937 Applic. Date: 2006-09-22

Inventor: LAUNAY NATHALIE [FR]; PASSARO GHISLAINE [FR]; DEMARNE FREDERIC [FR]


Application No.: US20090297645A1  Published: 03/Dec/2009

Title: Fibroblast Activator and Method of Activating Fibroblast, Collagen Synthesis Promoter and Method of Promoting Collagen Synthesis, and Skin Antiaging Agent and Method of Preventing Aging of Skin

Applicant/Assignee:

Application No.: 12/083834   Filing Date: 17/Oct/2006

Abstract:The present invention relates to a fibroblast activator comprising grape sap as an active ingredient, a method of activating a fibroblast, using grape sap, and a method of using grape sap as a fibroblast activator. The present invention further relates to a collagen synthesis promoter comprising grape sap as an active ingredient, a method of promoting collagen synthesis using grape sap, and a method of using grape sap as a collagen synthesis promoter. The present invention further relates to a skin antiaging agent comprising grape sap as an active ingredient, a method of preventing aging of skin using grape sap, and a method of using grape sap as a skin antiaging agent. The present invention provides highly safe and effective means of preventing aging.

Priority: JP20050302591 Applic. Date: 2005-10-18; WO2006JP320614 Applic. Date: 2006-10-17

Inventor: WATANABE AZUMA [JP]; IMAMURA KAZUYUKI [JP]


Application No.: US20090298759A1  Published: 03/Dec/2009

Title: C-Reactive Protein and Its Use to Treat Systemic Lupus Erythematosus and Related Conditions

Applicant/Assignee: STC.UNM

Application No.: 12/083055   Filing Date: 26/Oct/2006

Abstract:The present invention relates to the use of C-reactive protein, its mutants, metabolites and polypeptides and related compounds thereof for the treatment of various disease states and conditions associated with systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein, in another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition with systemic lupus erythematosus will have an outbreak is an additional aspect of the present invention.

Priority: US20050730013P Applic. Date: 2005-10-26; WO2006US41583 Applic. Date: 2006-10-26

Inventor: DU CLOS TERRY W [US]; MOLD CAROLYN [US]


Application No.: US20090298766A1  Published: 03/Dec/2009

Title: DETECTION AND TREATMENT OF CANCERS

Applicant/Assignee:

Application No.: 12/293124   Filing Date: 15/Mar/2007

Abstract:The present invention relates to methods and compositions for the detection and treatment of melanoma and skin cancers. More particularly, the invention discloses that BCSC-1 expression is altered in melanoma and skin cancer cells, allowing the design of effective detection methods and kits for such conditions. The invention also shows that restoring or increasing expression of BCSC-1 in melanoma and skin cancer cells suppresses tumorigenicity and represents a novel and effective approach for the treatment of melanoma and skin cancers. The invention may be used to detect the presence, stage or type of melanoma and skin cancers, as well as any predisposition thereto. The invention may be used in any mammalian subject, particularly human subjects.

Priority: EP20060290425 Applic. Date: 2006-03-16; WO2007IB01721 Applic. Date: 2007-03-15

Inventor: PIGUET VINCENT A [CH]; CORREA ROCHA RAFAEL [ES]; BRACCO LAURENT [FR]


Application No.: US20090298800A1  Published: 03/Dec/2009

Title: 1,25-DIHYDROXY, 20-CYCLOPROPYL,26-27-DEUTEROALKYL VITAMIN D3 COMPOUNDS AND METHODS OF USE THEREOF

Applicant/Assignee: BIOXELL S.P.A

Application No.: 12/067873   Filing Date: 21/Sep/2006

Abstract:The invention provides vitamin D3 analogs of cholecalciferol, substituted at carbons-26 and 27 with deuterated alkyl groups, e.g., trideuteromethyl, wherein carbon-16 is a single or double bond, and carbon-23 is a single, double, or triple bond. The invention provides pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.

Priority: US20050720234P Applic. Date: 2005-09-23; US20050729438P Applic. Date: 2005-10-21; WO2006US36944 Applic. Date: 2006-09-21

Inventor: USKOKOVIC MILAN R [US]; MARCZAK STANISLAW [US]; JANKOWSKI PAWEL [US]; ADORINI LUCIANO [IT]


Application No.: US20090298801A1  Published: 03/Dec/2009

Title: Petroleum jelly-free unguent compositions comprising vitamin D compounds and optionally steroidal anti-inflammatory agents

Applicant/Assignee: GALDERMA S.A

Application No.: 12/457029   Filing Date: 29/May/2009

Abstract:Novel compositions in petroleum jelly-free unguent form, in particular for topical application, contain a vitamin D compound and optionally an active agent of the family of steroidal anti-inflammatory agents.

Priority: FR20060055205 Applic. Date: 2006-11-30; WO2007FR52432 Applic. Date: 2007-11-30

Inventor: WILLCOX NATHALIE [FR]; BARTHEZ NATHALIE [FR]; NADAU-FOURCADE KARINE [FR]; MALLARD CLAIRE [FR]


Application No.: US20090298812A1  Published: 03/Dec/2009

Title: Substituted Sulfonamide Compounds

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 12/397771   Filing Date: 04/Mar/2009

Abstract:Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.

Priority: EP20080004073 Applic. Date: 2008-03-05; US20080033987P Applic. Date: 2008-03-05

Inventor: OBERBOERSCH STEFAN [DE]; JOSTOCK RUTH [DE]; SCHIENE KLAUS [DE]; DE VRY JEAN [DE]; GERMANN TIENO [DE]; HEES SABINE [DE]; SCHUNK STEFAN [DE]; REICH MELANIE [DE]


Application No.: US20090298835A1  Published: 03/Dec/2009

Title: NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY

Applicant/Assignee: THE SCRIPPS RESEARCH INSTITUTE

Application No.: 12/503589   Filing Date: 15/Jul/2009

Abstract:Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated by alpha-helix-binding receptors and proteins.

Priority: US2006-368302 Applic. Date: 2006-03-03; US20050660939P Applic. Date: 2005-03-11

Inventor: REBEK JR JULIUS [US]; GU SHEN [US]; BIROS SHANNON [US]


Application No.: US20090298868A1  Published: 03/Dec/2009

Title: QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/433863   Filing Date: 30/Apr/2009

Abstract:A method of identification of quinoline compounds (formula I) that modify melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to control (e.g., inhibit) melanin production are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, pigmentation deficiencies (albinism) and hyperpigmentation and others.

Priority: WO2008US12837 Applic. Date: 2008-11-14; US20070988095P Applic. Date: 2007-11-14; US20070988097P Applic. Date: 2007-11-14; US20080098231P Applic. Date: 2008-09-18

Inventor: ORLOW SETH J [US]; KOMATSU LI NI [US]


Application No.: US20090298915A1  Published: 03/Dec/2009

Title: TOPICAL DRUG DELIVERY

Applicant/Assignee:

Application No.: 12/295603   Filing Date: 30/Mar/2007

Abstract:Poly-pseudo-lysine conjugates have been shown to be able to penetrate into human skin and are proposed for both therapeutic and cosmetic treatments by topical application, e.g. change of skin pigmentation.

Priority: GB20060006415 Applic. Date: 2006-03-31; WO2007GB01193 Applic. Date: 2007-03-30

Inventor: HEALY EUGENE PIUS JOSEPH [GB]; FRIEDMANN PETER SIMON [GB]; BRADLEY MARK [GB]


Application No.: US20090304592A1  Published: 10/Dec/2009

Title: TREATMENT OF METASTATIC TUMORS

Applicant/Assignee:

Application No.: 12/466599   Filing Date: 15/May/2009

Abstract:The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.

Priority: US20080053651P Applic. Date: 2008-05-15; US20090173121P Applic. Date: 2009-04-27; US20090153273P Applic. Date: 2009-02-17

Inventor: O'NEILL ALISON [US]; JACOBY DOUGLAS B [US]; SENTISSI ABDELLAH [US]; KESAVAN KAMALA [US]; EGAN E MICHAEL [US]; SEN LAURA [US]


Application No.: US20090304613A1  Published: 10/Dec/2009

Title: USE OF A LIMNOPHILA EXTRACT AS A COSMETIC AGENT, AND COSMETIC COMPOSITION CONTAINING SAME

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/477479   Filing Date: 03/Jun/2009

Abstract:The invention relates to the use of a plant extract of a plant of the Limnophila genus, in particular an extract of the plant species Limnophila conferta, as a cosmetic agent or as an active agent in cosmetic compositions.

Priority: FR20080053797 Applic. Date: 2008-06-06

Inventor: LEPLANQUAIS VIRGINIE [FR]; PECHER VIRGINIE [FR]; DUMAS MARC CM [FR]; LAZOU KRYSTELL [FR]


Application No.: US20090304615A1  Published: 10/Dec/2009

Title: TRICYCLIC COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/433860   Filing Date: 30/Apr/2009

Abstract:A method of identification of tricyclic compounds (formula I) that control melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to modify (e.g., inhibit) melanin production are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, hyperpigmentation and others.

Priority: WO2008US12838 Applic. Date: 2008-11-14; US20070988094P Applic. Date: 2007-11-14

Inventor: ORLOW SETH J [US]; KOMATSU LI NI [US]


Application No.: US20090304617A1  Published: 10/Dec/2009

Title: LOW RESIDUE ANTIPERSPIRANT STICK

Applicant/Assignee:

Application No.: 12/492278   Filing Date: 26/Jun/2009

Abstract:The present invention relates to low residue, water-free antiperspirant sticks with enhanced properties.

Priority: DE200610062567 Applic. Date: 2006-12-29; DE200710059678 Applic. Date: 2007-12-10; WO2007EP63652 Applic. Date: 2007-12-11

Inventor: BANOWSKI BERNHARD [DE]; CLAAS MARCUS [DE]; WADLE ARMIN [DE]


Application No.: US20090304693A1  Published: 10/Dec/2009

Title: Dual Variable Domain Immunoglobulins and Uses Thereof

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/477668   Filing Date: 03/Jun/2009

Abstract:The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Priority: US20080130776P Applic. Date: 2008-06-03; US20080132951P Applic. Date: 2008-06-24

Inventor: GHAYUR TARIQ [US]; HAHN ALFRED [DE]; MUELLER BERNHARD [DE]


Application No.: US20090304706A1  Published: 10/Dec/2009

Title: ANTAGONIST ANTI-CD40 ANTIBODY PHARMACEUTICAL COMPOSITIONS

Applicant/Assignee: NOVARTIS AG XOMA TECHNOLOGY LTD

Application No.: 12/297382   Filing Date: 17/Apr/2007

Abstract:Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.

Priority: US20060794011P Applic. Date: 2006-04-21; WO2007US66757 Applic. Date: 2007-04-17

Inventor: LU XIAOFENG [US]; CHEN BAO-LU [US]; ARAYA KIDISTI [US]; OKHAMAFE AUGUSTUS [US]


Application No.: US20090304829A1  Published: 10/Dec/2009

Title: USE OF A LEPECHINIA CAULESCENS EXTRACT AS A COSMETIC AGENT, AND COSMETIC COMPOSITION CONTAINING SAME

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/477433   Filing Date: 03/Jun/2009

Abstract:he invention relates to the use of a plant extract of a plant belonging to the Lepechinia genus, in particular an extract of the plant species Lepechinia caulescens, as a cosmetic agent or as an active agent in cosmetic compositions.

Priority: FR20080053795 Applic. Date: 2008-06-06

Inventor: PECHER VIRGINIE [FR]; LEPLANQUAIS VIRGINIE [FR]; LAZOU KRYSTELL [FR]; DUMAS MARC CM [FR]


Application No.: US20090305048A1  Published: 10/Dec/2009

Title: Process for the treatment of a hydrophobic surface by an aqueous phase

Applicant/Assignee: RHODIA OPERATIONS

Application No.: 12/294178   Filing Date: 22/Mar/2007

Abstract:The invention relates to process for the treatment of a hydrophobic surface by a liquid film comprising an aqueous phase comprising the coating of said surface by the liquid whose aqueous phase comprises an effective amount of surface properties modifying agent and an active agent.

Priority: US20060785289P Applic. Date: 2006-03-23; WO2007EP52774 Applic. Date: 2007-03-22

Inventor: CASTAING JEAN-CHRISTOPE [US]; RAO ASHWIN [US]


Application No.: US20090305381A1  Published: 10/Dec/2009

Title: Activated Polymers Binding Biological Molecules

Applicant/Assignee:

Application No.: 12/225022   Filing Date: 15/Mar/2007

Abstract:The present invention relates to activated polymer substrates capable of binding functional biological molecules, to polymer substrates comprising bound and functional biological molecules, to devices comprising such substrates and to methods of producing them.

Priority: AU20060901344 Applic. Date: 2006-03-15; WO2007AU00321 Applic. Date: 2007-03-15

Inventor: BILEK MARCELA [AU]; MCKENZIE DAVID [AU]; NOSWORTHY NIEL [AU]; KONDYURIN ALEKSEY [AU]


Application No.: US20090305969A1  Published: 10/Dec/2009

Title: Skin Repair Accelerating Therapeutic Agent Containing Desacyl Ghrelin and Derivatives Thereof as Active Ingredient

Applicant/Assignee:

Application No.: 12/085220   Filing Date: 21/Nov/2006

Abstract:The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing desacyl ghrelin or a pharmaceutically acceptable salt thereof as an active ingredient.

Priority: JP20050336420 Applic. Date: 2005-11-21; WO2006JP323231 Applic. Date: 2006-11-21

Inventor: MURAKAMI NOBORU [JP]; NAKAHARA KEIKO [JP]; KANGAWA KENJI [JP]; HAYASHI YUJIRO [JP]


Application No.: US20090305975A1  Published: 10/Dec/2009

Title: Use of Trap Protein Per se as an Active Ingredient for the Manufacture of a Medicament for the Treatment of Staphylococcus Aureus Infection

Applicant/Assignee:

Application No.: 12/226491   Filing Date: 16/Apr/2007

Abstract:Disclosed herein is the use of TRAP per se as an active ingredient for the manufacture of a medicament for the treatment of Staphylococcus aureus infection. An exogenous TRAP (native TRAP or recombinant TRAP) per se can effectively inhibit the production of Staphylococcus aureus exotoxins, thereby reducing the pathogenicity of Staphylococcus aureus. In addition, a medicament including TRAP also stimulates the production of corresponding antibodies in human body at the time when it is used to treat Staphylococcus aureus infections, and these antibodies can further inhibit the production of Staphylococcus aureus exotoxins. Such double actions increase the effects of medicament and provide a novel medicament action mode. Moreover, since TRAP functions merely to the toxicity of bacteria but does not affect the growth of bacteria, it cannot make bacteria readily develop drug resistance, and also effective to drug resistant Staphylococcus aureus. Moreover, no homologous sequence of the TRAP proteins is found in human genome, so that the medicaments of TRAP cannot cause human immunologic diseases.

Priority: CN20061075638 Applic. Date: 2006-04-17; WO2007CN01246 Applic. Date: 2007-04-16

Inventor: YANG GUANG [CN]; SHAO NINGSHENG [CN]; GAO YAPING [CN]; LIU YU [CN]; DONG JIE [CN]; LI SHAOHUA [CN]; LIU CHUAN [CN]; SHEN BEIFEN [CN]; FAN MING [CN]


Application No.: US20090305995A1  Published: 10/Dec/2009

Title: AGONISTS AND ANTAGONISTS OF THE SOMATOSTATIN RECEPTOR

Applicant/Assignee: NOVARTIS AG

Application No.: 11/719474   Filing Date: 14/Nov/2005

Abstract:The invention relates to substituted F3-Phe-trp-F 3-Lys-beta-tri-peptides and derivatives thereof, a process for their preparation, pharmaceutical preparations which contain these compounds which are agonists/antagonists of somatostatin receptors, as active agents for the treatment of disorders which can be influenced by a modulation of somatostatin receptor activity, in particular somatostatin receptor sst4 activity, by the compounds of the invention.

Priority: GB20040025258 Applic. Date: 2004-11-16; WO2005EP12178 Applic. Date: 2005-11-14

Inventor: KRAWINKLER KARL HEINZ [CH]; MEIER PETER [CH]; FALLER BERNARD [FR]


Application No.: US20090305997A1  Published: 10/Dec/2009

Title: USE OF A GALACTOSE-DERIVED C-GLYCOSIDE COMPOUND AS AN AGENT FOR ACTIVATING AND REGULATING CUTANEOUS IMMUNITY

Applicant/Assignee: L'OREAL

Application No.: 12/296310   Filing Date: 05/Apr/2007

Abstract:The present invention relates to a novel galactose derivatives of general formula (I) and to their use as agents for stimulating the immune system of the skin and/or as immunoregulators, and for preparing a composition containing a cosmetically or pharmaceutically acceptable medium, intended in particular to prevent and/or limit the appearance of cutaneous immune imbalances, in particular related to environmental stresses.

Priority: FR20060051273 Applic. Date: 2006-04-07; US20060797381P Applic. Date: 2006-05-04; WO2007EP53360 Applic. Date: 2007-04-05

Inventor: PINEAU NATHALIE [FR]; DALKO MARIA [FR]


Application No.: US20090306011A1  Published: 10/Dec/2009

Title: Use Of An Alkyl Glycoside Or Of A Mixture Of At Least Two Alkyl Glycosides As Agent Intended For Inhibiting Microbial Growth, And Compositions Containing It

Applicant/Assignee: LVMH RECHERCHE UNIVERSITE DE PICARDIE JULES VERNE

Application No.: 12/415136   Filing Date: 31/Mar/2009

Abstract:The present invention relates to the use of an alkyl glycoside or of a mixture of at least two alkyl glycosides as agent intended for inhibiting microbial growth, in particular in a cosmetic, pharmaceutical or food composition.

Priority: FR20080052192 Applic. Date: 2008-04-02

Inventor: THIEBAULT NICOLAS [FR]; ARCHAMBAULT JEAN-CHRISTOPHE [FR]; ANDRE PATRICE [FR]; PILARD FLORENCE [FR]; MOREAU VINCENT [FR]


Application No.: US20090306082A1  Published: 10/Dec/2009

Title: NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applicant/Assignee: GLENMARK PHARMACEUTICALS S.A

Application No.: 11/721912   Filing Date: 15/Dec/2005

Abstract:The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, a diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.

Priority: IN2004MU01352 Applic. Date: 2004-12-17; WO2005IB03798 Applic. Date: 2005-12-15

Inventor: GHARAT LAXMIKANT ATMARAM [IN]; GOPALAN BALASUBRAMANIAN [IN]; JOSHI NEELIMA KHAIRATKAR [IN]


Application No.: US20090306163A1  Published: 10/Dec/2009

Title: TOPICAL COMPOSITIONS COMPRISING IMIDAZOLIDINEDIONE ANALOGS AND THEIR USE TO TREAT OR PREVENT THE APPEARANCE OF SKIN WRINKLING

Applicant/Assignee:

Application No.: 12/481718   Filing Date: 10/Jun/2009

Abstract:The described invention relates to the formulation and delivery of topical compositions comprising a cosmetically effective amount of at least one imidazolidinedione analog reduce the appearance of wrinkles.

Priority: US20080060200P Applic. Date: 2008-06-10

Inventor: LIPKIN PAMELA RENEE [US]


Application No.: US20090311184A1  Published: 17/Dec/2009

Title: HIGH PENETRATION PRODRUG COMPOSITIONS OF PEPTIDES AND PEPTIDE-RELATED COMPOUNDS

Applicant/Assignee:

Application No.: 12/463374   Filing Date: 08/May/2009

Abstract:The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Priority: WO2006IB54170 Applic. Date: 2006-11-08

Inventor: YU CHONGXI [US]


Application No.: US20090311202A1  Published: 17/Dec/2009

Title: COSMETIC PREPARATION FOR EXTENSION TANNING

Applicant/Assignee:

Application No.: 11/722001   Filing Date: 06/Dec/2005

Abstract:The invention relates to a cosmetic preparation for tan extension. The cosmetic includes as active ingredient a complex of 0.1 to 3.0 wt.-% caffeine, 0.2 to 2 wt.-% Phototan(R), 0.01 to 1.0 wt.-% copper gluconate and further cosmetic auxiliaries, excipients, further active substances and mixtures thereof to make 100 wt.-%. It is possible to achieve a sun tan extension of up to 7 to 9 days, and in some cases up to 11 days.

Priority: DE200410062170 Applic. Date: 2004-12-17; WO2005EP13197 Applic. Date: 2005-12-06

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [DE]


Application No.: US20090311203A1  Published: 17/Dec/2009

Title: GEM-DIFLUORIDE C-GLYCOPEPTIDE COMPOUNDS, THEIR PREPARATION AND USE PARTICULARLY FOR PRESERVATION OF BIOLOGICAL MATERIALS

Applicant/Assignee: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (INSA)

Application No.: 12/299453   Filing Date: 26/Apr/2007

Abstract:The invention relates to a gem-difluoride C-glycopeptide compound with formula I where n is an integer equal to 3 or 4, R represents a hydrogen atom, an alkyl, benzyl, acetyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl group, R' represents OR, NR'R'', N3, or a phthalimide, R' and R'' represent a hydrogen atom or an alkyl, aryl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl, benzyloxycarbonyl group, R1 represents a hydrogen atom or an alkyl, benzyl, alkylcarbamate, allylcarbamate, benzylcarbamate, acetyl group, R1 may consist of an amino acid if R2 represents only OR, R2 includes an amino acid if R1 represents a hydrogen atom or an alkyl, benzyl, alkylcarbamate, allylcarbamate, benzylcarbamate, acetyl group, R2 represents OR when R1 represents an amino acid, R3 represents a hydrogen atom or a free or protected alcohol function. It is applicable to the preparation of compounds or compositions to be used for preservation of biological materials such as cells, tissues and organs at various temperatures.

Priority: FR20060003952 Applic. Date: 2006-05-03; WO2007FR00716 Applic. Date: 2007-04-26

Inventor: CASTELOT DELIENCOURT-GODEFROY [FR]; QUIRION JEAN-CHARLES [FR]


Application No.: US20090311204A1  Published: 17/Dec/2009

Title: CAROTENOID COMPOSITIONS USEFUL FOR WHITENING SKIN

Applicant/Assignee:

Application No.: 12/306888   Filing Date: 29/May/2007

Abstract:The present invention relates to use of carotenoid preparations for promoting skin whitening. Particularly, the present invention discloses that a combination of phytoene and phytofluene is effective in whitening skin. The present invention further relates to carotenoid compositions comprising a combination of phytofluene and phytofluene effective in whitening skin and at least one additional carotenoid, particularly carotenoids devoid of highly intense color.

Priority: IL20060176668 Applic. Date: 2006-07-02; WO2007IL00648 Applic. Date: 2007-05-29

Inventor: VON OPPEN BEZALEL LIKI [DE]; SOUDANT ETIENNE [FR]; PERRY INON [IL]; MANIWA FUMIO [JP]; HATA YUKI [JP]; TAKAYAMA AKEMI [JP]


Application No.: US20090311208A1  Published: 17/Dec/2009

Title: Oil In Silicone Emulsions and Compositions Containing Same

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 12/544475   Filing Date: 20/Aug/2009

Abstract:The present invention provides an oil in silicone emulsion and an oil in silicone/water in silicone dual emulsion. These emulsions employ a silicone resin as the emulsifying agent, include an effective amount of one or more active ingredients, such as, a sunscreen and/or insect repellent and provide enhanced aesthetics and SPF. Also provided are methods of preparation of the oil in silicone and the oil in silicone/water in silicone dual emulsions, compositions that employ the emulsions and methods of using the compositions to repel insects from skin and protect skin from exposure to the sun.

Priority: US2003-747320 Applic. Date: 2003-12-26

Inventor: GARRISON MARK S [US]; ARMSTRONG MICHAEL [US]


Application No.: US20090311253A1  Published: 17/Dec/2009

Title: Dual Variable Domain Immunoglobulins and Uses Thereof

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/477711   Filing Date: 03/Jun/2009

Abstract:The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Priority: US20080130817P Applic. Date: 2008-06-03; US20080197172P Applic. Date: 2008-10-23

Inventor: GHAYUR TARIQ [US]; ISAKSON PETER C [US]; OLSON LISA M [US]; WU CHENGBIN [US]; HUGUNIN MARGARET [US]; KAMATH RAJESH V [US]; CUFF CAROLYN A [US]; ALLEN HAMISH J [US]


Application No.: US20090311295A1  Published: 17/Dec/2009

Title: PARTICLES WITH HIGH UNIFORM LOADING OF NANOPARTICLES AND METHODS OF PREPARATION THEREOF

Applicant/Assignee:

Application No.: 12/300304   Filing Date: 14/May/2007

Abstract:Methods to produce polymeric microparticles containing nanoparticles such, as pigments, dyes and other chromophores for cosmetic use, plastic surgery therapeutic use, and tattoos have been developed. The microparticles contain within the polymer a very uniform dispersion of dye particles. The methods by which the particles are made ensure a homogeneous mixture and high loading. The microparticles are made using air, one of a number of known methods such as phase inversion, solvent evaporation, and melt processing. The improvement is in the use of a method that makes, a stable dispersion of the nanoparticles in the liquid polymer before formation of the microparticles. This is achieved through selection of appropriate solvent, optionally including surfactant, and then subjecting the dispersion to mechanical processing that stabilizes the dispersion within the polymer solvent, so that the nanoparticles remain suspended for at least thirty minutes, in some cases two hours to 48 hours, sometimes up to three months. The mechanical processing can be sonication and/or production of shear forces, for examples, resulting from use of an open blade or rotor stator mixer or milling with a concentric shaft, at a speed such as between 5000 and 25,000 RPM.

Priority: US20060747141P Applic. Date: 2006-05-12; WO2007US68881 Applic. Date: 2007-05-14

Inventor: MATHIOWITZ EDITH [US]; KUNDAKOVIC LJILJANA [US]; MORELLO A PETER [US]; HARRISON MICHAEL W [US]; REINEKE JOSHUA JAMES [US]


Application No.: US20090311308A1  Published: 17/Dec/2009

Title: SKINCARE COMPOSITIONS COMPRISING SALICYCLIC ACID

Applicant/Assignee: RECKITT & COLMAN (OVERSEAS) LIMITED

Application No.: 12/537514   Filing Date: 07/Aug/2009

Abstract:There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises salicylic acid or a salt thereof and hydrolysed milk protein. The composition is useful in the treatment of acne.

Priority: GB20040003702 Applic. Date: 2004-02-19; GB20040019260 Applic. Date: 2004-08-31; US2005-590061 Applic. Date: 2005-02-19; WO2005GB00503 Applic. Date: 2005-02-19

Inventor: STRODTHOLZ IRIS [DE]; SCHMIDT TIMM [DE]; STRAHINJIC IVANA [DE]


Application No.: US20090311406A1  Published: 17/Dec/2009

Title: PRODUCTS CONTAINING SMART FOAM AND METHOD OF MAKING

Applicant/Assignee: NESTEC S.A

Application No.: 12/374271   Filing Date: 12/Jul/2007

Abstract:A foamed delivery system having at least two components: a foam and an additive that is associated with, carried by or delivered by the foam. The foam is a stable foam that has a liquid matrix, gas bubbles and a structuring agent that forms a lamellar or vesicular cage structure without generating a gel imparting a rubbery texture. The lamellar cage structure entraps at least a substantial portion of the gas bubbles and liquid matrix therein to retain the gas bubbles and liquid in a sufficiently compact structure that substantially prevents drainage of the liquid matrix and coalescence and creaming of the gas bubbles to maintain stability of the foam even when the foam is subjected to heat shock. Combined with the stable foam structure the distribution and release of the additive during application is significantly improved.

Priority: US20060831609P Applic. Date: 2006-07-17; WO2007EP57175 Applic. Date: 2007-07-12

Inventor: TAPFER KARL UWE [US]; WINDHAB ERICH JOSEF [CH]


Application No.: US20090312245A1  Published: 17/Dec/2009

Title: SRA binding protein

Applicant/Assignee: THE UNIVERSITY OF WESTERN AUSTRALIA

Application No.: 12/009690   Filing Date: 22/Jan/2008

Abstract:An isolated polypeptide comprising: (i) SEQ ID No: 2

(ii) amino acids 27 to 109 of SEQ ID No: 2 (iii) amino acids 22 to 109 of SEQ ID No: 2 (iv) amino acids 21-91 of SEQ ID No: 2 (v) amino acids 21-26 and/or 60-67 of SEQ ID No: 2 or (vi) a functional variant of any one of (i) to (v).

Priority: AU20050903903 Applic. Date: 2005-07-22; AU20050907268 Applic. Date: 2005-12-23; AU20060903090 Applic. Date: 2006-06-07; WO2006AU01037 Applic. Date: 2006-07-24

Inventor: LEEDMAN PETER [AU]; HATCHELL ESME [AU]; COLLEY SHANE [AU]


Application No.: US20090312288A1  Published: 17/Dec/2009

Title: KINASE INHIBITORS

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 12/425249   Filing Date: 16/Apr/2009

Abstract:Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20080045565P Applic. Date: 2008-04-16

Inventor: BROWN JASON W [US]; DONG QING [US]; GANGLOFF ANTHONY R [US]; PARASELLI BHEEMA R [US]; SCORAH NICHOLAS [US]; STAFFORD JEFFREY A [US]; DAS SANJIB [IN]; SALSBURY JONATHON S [US]


Application No.: US20090312421A1  Published: 17/Dec/2009

Title: GEL USEFUL FOR THE DELIVERY OF COSMETIC ACTIVE INGREDIENTS

Applicant/Assignee: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA

Application No.: 11/913884   Filing Date: 11/May/2007

Abstract:It is described a gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles.

Priority: WO2007EP54574 Applic. Date: 2007-05-11

Inventor: LONGO ANTONIO [IT]; SANTANIELLO MOSE [IT]; RISI PAOLA [IT]


Application No.: US20090312440A1  Published: 17/Dec/2009

Title: AGENT FOR IMPROVING TISSUE PENETRATION

Applicant/Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSHAFTEN E.V GENZYME CORPORATION

Application No.: 12/357003   Filing Date: 21/Jan/2009

Abstract:The invention concerns a pharmaceutical preparation which improves penetration of active substances through the tissue membrane or barrier of the target organ.

Priority: DE20011022855 Applic. Date: 2001-05-11; US2007-716669 Applic. Date: 2007-03-12; US2003-477562 Applic. Date: 2003-11-12; WO2002EP05242 Applic. Date: 2002-05-13

Inventor: EIBL HANSJORG [DE]; HOFFMAN PETER [US]


Application No.: US20090313707A1  Published: 17/Dec/2009

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC LEXICON PHARAMACEUTICALS, INC

Application No.: 11/814361   Filing Date: 18/May/2006

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20050687900P Applic. Date: 2005-06-06; US20060780262P Applic. Date: 2006-03-07; WO2006US19651 Applic. Date: 2006-05-18

Inventor: COMBS KATHERIN E [US]; CULBERTSON LING LING [US]; DE SAUVAGE FREDERIC J [US]; DING ZHIYONG [US]; EDWARDS JOEL [US]; GIRGIS ROSEMARY [US]; HORNER ALLISON A B [US]; JUNGE HARALD [US]; JUNUTULA JAGATH REDDY [US]; MASSEY ERIN MARIE [US]; MCLAIN DINA R [US]; MONTGOMERY CHARLES [US]; PAYNE BOBBY JOE [US]; PHILLIPS HEIDI [US]; QIAN NI NANCY [US]; RANGEL CAROLINA [US]; SEVAUX TRACY E W [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; STALA JOY ANNE [US]; VOGEL PETER [US]; YE WEILAN [US]


Application No.: US20090317338A1  Published: 24/Dec/2009

Title: FOAMABLE IODINE COMPOSITIONS

Applicant/Assignee: FOAMIX LTD

Application No.: 12/499609   Filing Date: 08/Jul/2009

Abstract:The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.

Priority: US2004-835359 Applic. Date: 2004-04-28; US20030466094P Applic. Date: 2003-04-28

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20090317343A1  Published: 24/Dec/2009

Title: Personal Care Compositions Containing Silicone Elastomer Gels

Applicant/Assignee:

Application No.: 12/520579   Filing Date: 19/Dec/2007

Abstract:Personal care compositions are disclosed containing a silicone elastomer from the reaction of an organohydrogen-siloxane having at least two SiH containing cyclosiloxane rings in its molecule, a compound having at least two aliphatic unsaturated groups in its molecule, and a hydrosilylation catalyst.

Priority: US20060878012P Applic. Date: 2006-12-29; WO2007US25968 Applic. Date: 2007-12-19

Inventor: LIN SHAOW [US]; VAN REETH ISABELLA [CN]


Application No.: US20090317346A1  Published: 24/Dec/2009

Title: DEODORANT AGENT

Applicant/Assignee: KAO CORPORATION

Application No.: 12/548998   Filing Date: 27/Aug/2009

Abstract:This invention relates to deodorant agents, which contain ginkgo or Phellodendron Bark or its extract as an active ingredient. According to the present invention, deodorant agents which are high in safety and can radically inhibit the emission of human body malodors typified by sweat odor, especially, axillary odor.

Priority: JP20030103171 Applic. Date: 2003-04-07; US2005-550858 Applic. Date: 2005-09-26; WO2003JP11982 Applic. Date: 2003-09-19

Inventor: AKIBA SYUNICHI [JP]; ARA KATSUTOSHI [JP]; KUSUOKU HIROSHI [JP]; HAGURA TOYOKI [JP]


Application No.: US20090317354A1  Published: 24/Dec/2009

Title: Composition for restoring damaged skin comprising a saccaride and povidone-iodine

Applicant/Assignee: KOWA CO., LTD TEIKA PHARMACEUTICAL CO., LTD

Application No.: 12/583729   Filing Date: 25/Aug/2009

Abstract:The present invention relates to a composition for repairing injured skin containing a saccharide and povidone-iodine. The present invention has the following characteristics: suppresses time-dependent increase of consistency, it is easy to use, it is a soft preparation, and has superior applicability to a deep wounded lesion and a granulation tissue. The composition of the present invention contains 50 to 90% by weight of saccharide, 0.5 to 10% by weight of povidone-iodine, 0.1 to 20% by weight of water and 0.01 to 10% by weight of phospholipid.

Priority: JP20020326535 Applic. Date: 2002-11-11; US2005-533659 Applic. Date: 2005-05-05; WO2003JP14251 Applic. Date: 2003-11-10

Inventor: NISHIMURA MASAHIRO [JP]; NITO SHIHOMI [JP]; INAGI TOSHIO [JP]; KIMURA TAKAHITO [JP]


Application No.: US20090317395A1  Published: 24/Dec/2009

Title: Antimicrobial Peptide Derived from Galanin Message Associated Peptide (GMAP)

Applicant/Assignee:

Application No.: 12/306989   Filing Date: 27/Jun/2007

Abstract:The present invention relates to a new antimicrobial peptide, comprising the amino acid sequence of human galanin message associated peptide (GMAP) or a homolog, ortholog, chemically modified variant or antimicrobially active variant thereof, and respective uses thereof, particular in the topical treatment of antimicrobial diseases.

Priority: EP20060014350 Applic. Date: 2006-07-11; WO2007EP05693 Applic. Date: 2007-06-27

Inventor: KOFLER BARBARA [AT]; RAUCH ISABELLA [AT]


Application No.: US20090317430A1  Published: 24/Dec/2009

Title: COSMETIC COMPOSITION FOR LIGHTENING OR UNIFYING THE COMPLEXION

Applicant/Assignee: L'OREAL

Application No.: 12/438218   Filing Date: 29/Jun/2007

Abstract:Cosmetic composition for lightening or unifying the complexion The present invention relates to a composition comprising, in a physiologically acceptable medium, concave or annular particles, especially in the form of hollow sphere portions, the said particles comprising a matrix that is coloured in the bulk.

Priority: FR20060053423 Applic. Date: 2006-08-22; US20060840022P Applic. Date: 2006-08-25; WO2007EP56586 Applic. Date: 2007-06-29

Inventor: CASSIN GUILLAUME [FR]; SIMONNET JEAN-THIERRY [FR]


Application No.: US20090317472A1  Published: 24/Dec/2009

Title: CONTROLLED RELEASES OF ACTIVES IN SKIN

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 12/525529   Filing Date: 31/Jan/2008

Abstract:Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer

and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is -C -R-C- or -C-

Z is between 2 and about 100, inclusive

R1 is CH-CH or (CH2), wherein n is from 0 to 18, inclusive

R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms

and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

Priority: US20070887553P Applic. Date: 2007-01-31; WO2008US52728 Applic. Date: 2008-01-31

Inventor: KOHN JOACHIM B [US]; MICHNIAK BOZENA [US]; DEVORE DAVID [US]; SHEIHET LARISA [US]; CHANDRA PRAFULLA [US]; BATHEJA PRIYA [US]


Application No.: US20090318370A1  Published: 24/Dec/2009

Title: NOVEL GLYCOCONJUGATED CHLORIN DERIVATIVES AND METHOD OF PRODUCING THE SAME

Applicant/Assignee: REI MEDICAL CO., LTD

Application No.: 12/309965   Filing Date: 12/Feb/2008

Abstract:Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X1 to X20 independently represent a group selected from the group consisting of F-, sugar-S-, sugar-Z-S- and sugar-O-Z-S- and at least one among X1 to X20 represents a group selected from the group consisting of sugar-S-, sugar-Z-S- and sugar-O-Z-S- (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms)

and R5 and R6 independently represent a hydrogen atom or an organic group or may together form a ring.

Priority: JP20070038489 Applic. Date: 2007-02-19; WO2008JP52277 Applic. Date: 2008-02-12

Inventor: OBATA MAKOTO [JP]; YANO SHIGENOBU [JP]; OBATA SHIHO [JP]


Application No.: US20090318375A1  Published: 24/Dec/2009

Title: Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same

Applicant/Assignee: HANMI PHARM CO., LTD

Application No.: 11/915929   Filing Date: 05/Jun/2006

Abstract:This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Priority: KR20050048923 Applic. Date: 2005-06-08; WO2006KR02157 Applic. Date: 2006-06-05

Inventor: KWON BO SUNG [KR]; KIM EUN SOOK [KR]; KIM HEE CHEOL [KR]; YUN SANGMIN [KR]; KO MYOUNG-SIL [KR]; SONG TAE HUN [KR]; KIM HAN KYONG [KR]; SUH KWEE HYUN [KR]; LEE GWANSUN [KR]


Application No.: US20090318388A1  Published: 24/Dec/2009

Title: METHOD OF ACTIVATION OF OXAZAPHOSPHORINES

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 12/375482   Filing Date: 06/Nov/2007

Abstract:The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject

and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.

Priority: US20060864846P Applic. Date: 2006-11-08; WO2007US23359 Applic. Date: 2007-11-06

Inventor: SPASOJEVIC IVAN [US]; COLVIN MICHAEL O [US]; BATINIC-HABERLE INES [US]; LUDEMAN SUSAN M [US]; GAMCSIK MICHAEL P [US]


Application No.: US20090318395A1  Published: 24/Dec/2009

Title: 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES

Applicant/Assignee: GRUNENTHAL GMBH

Application No.: 12/483869   Filing Date: 12/Jun/2009

Abstract:The present invention relates to the use of 3beta-hydroxychlormadinone acetate (17alpha-acetoxychloropregna-4,6-dien-3beta-ol-20-one) and/or 3alpha-hydroxychlormadinone acetate (17alpha-acetoxychloropregna-4,6-dien-3alpha-ol-20-one) for producing a medicament for treating skin, preferably human skin by means of topical application, and to a pharmaceutical or cosmetic composition containing 3beta-hydroxy-chlormadinone acetate and/or 3alpha-hydroxychlormadinone acetate.

Priority: DE200610062120 Applic. Date: 2006-12-22; WO2007EP11144 Applic. Date: 2007-12-19

Inventor: SCHRAMM GEORG [DE]; KNEIP CHRISTA [DE]


Application No.: US20090318550A1  Published: 24/Dec/2009

Title: Emulsions comprising at least one retinoid and benzoyl peroxide

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/457774   Filing Date: 22/Jun/2009

Abstract:Stable dermatological/cosmetic emulsions useful, e.g., for the treatment of acne vulgaris, contain, formulated into a physiologically acceptable medium, a homogeneous dispersion of at least one dispersed retinoid, dispersed benzoyl peroxide, at least one fatty phase, at least one hydrophilic phase and at least one emulsifier.

Priority: FR20060055783 Applic. Date: 2006-12-21; WO2007FR52606 Applic. Date: 2007-12-21

Inventor: MALLARD CLAIRE [FR]; LOUIS FABIENNE [FR]; WILLCOX NATHALIE [FR]


Application No.: US20090320179A1  Published: 31/Dec/2009

Title: PROPHYLACTIC ARTICLE

Applicant/Assignee:

Application No.: 12/389115   Filing Date: 19/Feb/2009

Abstract:The invention relates to a prophylactic article with a carrier element, which comprises at least in part a natural or synthetic elastomer, and with a combination of active substances that is contained in microcapsules, wherein the microcapsules are arranged at least in part in and/or on the carrier element. The combination of active substances contains at least one skin care agent, at least one preservative, at least one odor-inhibiting agent and at least one antioxidant.

Priority: AT20080000279 Applic. Date: 2008-02-21; US20080030350P Applic. Date: 2008-02-21

Inventor: SCHALLER RAIMUND [AT]


Application No.: US20090324505A1  Published: 31/Dec/2009

Title: Surfactant gas pressurized liquid composition and method and package for delivering

Applicant/Assignee:

Application No.: 12/217070   Filing Date: 30/Jun/2008

Abstract:A self gassing composition comprising at least one surfactant and a fermentation base including a gas producing organism and at least one sugar is disclosed. Use of a nonionic surfactant in the self gassing composition allows the fermentation base to continue reacting and producing gas. Additionally, a personal care cleansing product and method for storing and delivering an aqueous composition having at least one surfactant and pressurized gas dissolved therein is disclosed. In one aspect, the composition is stored in an internal reservoir in a container such that when a sealing device is removed from a valveless opening, the composition foams and plumes out the opening of the container as the gas dissolved in the composition is released. In addition to the self gassing composition, a pressurized gas may be injected into a surfactant composition to produce the gas pressurized cleaning composition.

Priority:

Inventor: SEIDLING JEFFERY RICHARD [US]; WENZEL SCOTT W [US]; MUNDSCHAU STACY AVERIC [US]; KOENIG DAVID W [US]


Application No.: US20090324506A1  Published: 31/Dec/2009

Title: Sprayable skin protectant formulation and method of use

Applicant/Assignee:

Application No.: 12/217042   Filing Date: 30/Jun/2008

Abstract:The present disclosure is directed to a skin protectant formulation that is designed to be sprayed onto human skin for the purpose of protecting the skin. In particular, an exemplary formulation of the present disclosure contains at least a carrier, a structurant and a skin protectant agent. An exemplary formulation contains a carrier comprising at least water, a structurant comprising at least a laponite clay, and a skin protectant agent comprising petrolatum. Typically, the skin protectant formulation will comprise at least about 30 wt. % of a skin protectant agent. A continuous spray dispenser may be used to apply the skin protectant formulation to reduce the need for rubbing as the treated area can be covered by a mist of the skin protectant formulation requiring no need to rub for application or small droplets that do not require extensive time for rubbing in.

Priority:

Inventor: SEIDLING JEFFERY RICHARD [US]; WENZEL SCOTT W [US]; LEMKE SARAH ANNE [US]; JOHNSON KROY DONALD [US]; MUNDSCHAU STACY AVERIC [US]


Application No.: US20090324521A1  Published: 31/Dec/2009

Title: Personal Care Article For Sequentially Dispensing Compositions With Variable Concentrations Of Hydrophobic Benefit Materials

Applicant/Assignee:

Application No.: 12/361492   Filing Date: 28/Jan/2009

Abstract:The personal care article comprises a single chamber package and a personal care product. The package comprises a dispensing orifice, a first zone, a second zone and a third zone that are located proximal, medial and distal to the dispensing orifice. The personal care product comprises a first, a second and a third personal care composition with a first, second, and third concentration of hydrophobic benefit material. The first, second, and third personal care compositions are substantially within the first, second and third zones. The personal care product comprises a second concentration that is greater than the first and third concentration of hydrophobic benefit material. The personal care product is sequentially dispensed, such that, the first personal care composition is capable of being substantially dispensed prior to the second and third personal care compositions and the second is capable of being substantially dispensed prior to the third personal care composition.

Priority: US2007-881551 Applic. Date: 2007-07-27

Inventor: CETTI JONATHAN ROBERT [US]; PUTMAN CHRISTOPHER DEAN [US]; FARRIS RICHARD DUFFY [US]; WEI KARL SHIQING [US]; ABSHER SARAH NOELLE [US]


Application No.: US20090324522A1  Published: 31/Dec/2009

Title: SKIN PROTECTANT COMPOSITIONS

Applicant/Assignee: WESTERN HOLDINGS, LLC

Application No.: 12/487526   Filing Date: 18/Jun/2009

Abstract:A topical composition for the protection of skin from damage caused by ultraviolet radiation. The composition includes a direct antioxidant and a phase 2 enzyme inducer (indirect antioxidant) in cosmetic and dermopharmaceutical compositions that protects and prevents skin damage and aging caused by UV radiation. In a particular embodiment, the composition includes a broccoli extract in combination with a composition including Hibiscus flower extract, Ferula Assa Foetida root extract, pear fruit extract, and green tea leaf extract, which exhibit a synergistic effect in protecting the skin from the adverse effects of ultraviolet radiation. In another embodiment, the composition further includes Vitamin C and Vitamin E. The antioxidant compositions can be incorporated into cosmetics, pharmaceutical compositions, sunscreen products, moisturizing lotions, skin toners, and other skin care products.

Priority: US20080073720P Applic. Date: 2008-06-18

Inventor: CHEVREAU NATHALIE [US]


Application No.: US20090324570A1  Published: 31/Dec/2009

Title: Photostabilization of Retinoids with Alkoxycrylene Compounds

Applicant/Assignee: HALLSTAR INNOVATIONS CORP

Application No.: 12/533598   Filing Date: 31/Jul/2009

Abstract:The photostabilizing electronic excited state energy-particularly singlet state energy from retinoid compounds-has been found to be readily transferred to (accepted by) alpha-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter "alkoxycrylenes") on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen

and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.

Priority: US2008-022758 Applic. Date: 2008-01-30; US2007-891281 Applic. Date: 2007-08-09

Inventor: BONDA CRAIG A [US]; PAVLOVIC ANNA [US]; ZHANG JEAN [US]


Application No.: US20090324584A1  Published: 31/Dec/2009

Title: Nucleic Acid of Formula (I): GIXmGn, or (II): CIXmCn, in Particular as an Immune-Stimulating Agent/Adjuvant

Applicant/Assignee: CUREVAC GMBH

Application No.: 12/375178   Filing Date: 31/Jul/2007

Abstract:The present invention relates to a nucleic acid of the general formula (I): GlXmGn, or (II): ClXmCn, which may be modified by a lipid. The nucleic acid of the invention acts as an immune-stimulating agent inducing the innate immune response. The invention relates further to a pharmaceutical composition (in a first embodiment), each containing an immune-stimulating agent according to the invention in combination with a pharmaceutically active carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). In another embodiment, the inventive nucleic acid is combined with at least one pharmaceutically active component, a pharmaceutically acceptable carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). Accordingly, the present invention is directed to a vaccine, which corresponds to a pharmaceutical composition of the invention (second embodiment), wherein the pharmaceutically active component induces a specific immune response (e.g. an antigen). The present invention relates likewise to the use of a nucleic acid of the invention or a pharmaceutical composition according to the invention for the treatment of infectious diseases, autoimmune diseases, allergies or cancer diseases.

Priority: DE200610035618 Applic. Date: 2006-07-31; WO2007EP06772 Applic. Date: 2007-07-31

Inventor: HOERR INGMAR [DE]; PROBST JOCHEN [DE]; KETTERER THOMAS [DE]; SCHEEL BIRGIT [DE]


Application No.: US20090324609A1  Published: 31/Dec/2009

Title: METHOD OF TREATING AUTOIMMUNE DISEASE WITH MESENCHYMAL STEM CELLS

Applicant/Assignee: GENZYME CORPORATION

Application No.: 12/188922   Filing Date: 08/Aug/2008

Abstract:Methods and compositions for treating an autoimmune disease, such as new onset type 1 diabetes (T1D) in a subject using autologous or allogeneic mesenchymal stem cells administered to the subject prior to autoimmune-induced complete depletion of insulin-producing pancreatic beta cells, e.g., within six months of new onset type 1 diabetes (T1D) diagnosis or prior to the onset of disease in a subject determined to be at high risk for T1D.

Priority: US20070954973P Applic. Date: 2007-08-09

Inventor: LODIE TRACEY [US]; YOUD MICHELE [US]; TUBO ROSS [US]; EISENBEIS SCOTT [US]


Application No.: US20090324663A1  Published: 31/Dec/2009

Title: KIT FOR FORMULATING A COSMETIC PRODUCT

Applicant/Assignee: L'OREAL

Application No.: 12/555161   Filing Date: 08/Sep/2009

Abstract:The present invention relates to kits for formulating a cosmetic product, containing an aqueous composition and at least one water-soluble anhydrous film, the aqueous composition and the film(s) being mixed together extemporaneously to form the cosmetic product.

Priority: FR20040004125 Applic. Date: 2004-04-19; US2005-105528 Applic. Date: 2005-04-14; US20040567312P Applic. Date: 2004-05-03

Inventor: LEGENDRE JEAN-YVES [FR]; GUIRAMAND CAROLE [FR]; CASSIN GUILLAUME [FR]; SIMONNET JEAN-THIERRY [FR]


Application No.: US20090324693A1  Published: 31/Dec/2009

Title: Delivery Product for Topical Compositions

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 12/164872   Filing Date: 30/Jun/2008

Abstract:A delivery product is used to deliver a skin composition to the skin of a user. The delivery product includes a thermo-responsive polymer film. The polymer film is solid at room temperature but, once contacted with the skin, increases in temperature and degrades. A skin composition is associated with the polymer film. The skin composition can be applied to a surface of the film or can be incorporated into the film. The skin composition is released by the polymer film for treating the skin of the user.

Priority:

Inventor: LEMKE SARAH ANNE [US]; JOHNSON KROY DONALD [US]


Application No.: US20090324700A1  Published: 31/Dec/2009

Title: METHODS AND COMPOSITIONS FOR THE INHIBITION OF CATHEPSINS

Applicant/Assignee:

Application No.: 12/121592   Filing Date: 15/May/2008

Abstract:Methods and compositions for modulating cell death by contacting a cell with an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. In addition, methods of treating a subject by providing the subject a composition that includes an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. The Spi2A polypeptide and Spi2A polypeptide equivalent can be delivered to the subject using gene therapy techniques. The subject can be a patient with a disease associated with an abnormal rate of cell death, such as septic shock or myocardial infarction. Also disclosed are methods of preparing and storing donor granulocytes, involving contacting the donor granulocytes with an Spi2A polypeptide or an Spi2A polypeptide equivalent.

Priority: US2004-782401 Applic. Date: 2004-02-19; US20030448285P Applic. Date: 2003-02-19

Inventor: ASHTON-RICKARDT PHILIP [US]


Application No.: US20090324709A1  Published: 31/Dec/2009

Title: LIPOSOMAL FORMULATIONS

Applicant/Assignee: ITALFARMACO, S.A

Application No.: 12/554216   Filing Date: 04/Sep/2009

Abstract:The invention relates to formulations of hydrophilic substances encapsulated in liposomes, to the method of encapsulation of the hydrophilic substances in the liposomes and the use of said formulations in the prevention and/or treatment of diseases and/or disorders in humans and animals.

Priority: ES20040000826 Applic. Date: 2004-04-02; ES20040002862 Applic. Date: 2004-11-26; US2005-599587 Applic. Date: 2005-04-01; WO2005ES00171 Applic. Date: 2005-04-01

Inventor: MOSCOSO DEL PRADO JAIME [ES]; CHANTRES ANTORANZ JOSE RAMON [ES]; ELORZA BARROETA MARIA ANGELES [ES]; ELORZA BARROETA BEGONA [ES]; CORDOBA DIAZ MANUEL [ES]


Application No.: US20090324737A1  Published: 31/Dec/2009

Title: Antimicrobial And Sporicidal Composition

Applicant/Assignee:

Application No.: 12/540845   Filing Date: 13/Aug/2009

Abstract:Germicidal compositions with enhanced activity towards killing microbiological spores and vegetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.

Priority: US2006-637603 Applic. Date: 2006-12-11; US2003-346216 Applic. Date: 2003-01-16; US20020350416P Applic. Date: 2002-01-18

Inventor: WALKER EDWARD B [US]


Application No.: US20090324752A1  Published: 31/Dec/2009

Title: COSMETIC USE OF ACTIVE INGREDIENTS INCREASING THE PRODUCTION OF GROWTH FACTORS

Applicant/Assignee: CHANEL PARFUMS BEAUTE

Application No.: 12/304637   Filing Date: 11/Jun/2007

Abstract:The invention relates to a cosmetic skin care method, intended to prevent and/or treat at least one cutaneous sign of ageing, including topical application to the skin of a composition containing at least one botanical active ingredient which increases the production by keratinocytes of at least one growth factor chosen from bFGF and PDGF.

Priority: FR20060005210 Applic. Date: 2006-06-12; US20060831667P Applic. Date: 2006-07-19; WO2007EP55714 Applic. Date: 2007-06-11

Inventor: LASSERRE CHRISTELLE MARIE SUZANNE [US]; MAESTRO YANNICK GERARD [FR]


Application No.: US20090325890A1  Published: 31/Dec/2009

Title: USE OF GALACTOSE C-GLYCOSIDE DERIVATIVES AS PROTECTIVE AGENT AND/OR GAMA DELTA T LYMPHOCYTE ACTIVATOR

Applicant/Assignee: L'OREAL

Application No.: 12/296313   Filing Date: 05/Apr/2007

Abstract:The present invention relates to the use of at least one galactose-derived C-glycoside of general formula (I): as an agent for protecting and/or stimulating the activity and/or the proliferation of gamma-delta T lymphocyte cells (gammadeltaT cells) in a composition containing a cosmetically or pharmaceutically acceptable medium. The composition will find applications for promoting skin tissue repair, for reequilibrating epidermal proliferation and differentiation disorders which appear with lack of sleep, and for improving the appearance of the head of hair and limiting hair loss.

Priority: FR20060051272 Applic. Date: 2006-04-07; WO2007EP53383 Applic. Date: 2007-04-05

Inventor: BRETON LIONEL [FR]


Application No.: US20090325894A1  Published: 31/Dec/2009

Title: TETRACYCLIC ANTHRAQUINONES POSSESSING ANTI-CANCER PROPERTIES

Applicant/Assignee:

Application No.: 12/504751   Filing Date: 17/Jul/2009

Abstract:The present invention provides aminoside tetracyclic anthraquinones represented by formula (I) or formula (II), wherein the peptides are introduced to connect tetracyclic anthraquinones and fatty acid saturated or unsaturated in order to make the anticancer agents to be absorbed and released selectively

meanwhile some water-solubility groups are also introduced into the branched chain, aminosaccharide and tetracyclic moiety of the compounds to improve the water-solubility. The present invention also provides the preparative method and the use thereof as pharmaceutically active components for treating the diseases cured by aminoside tetracyclic anthraquinone, for example cancer, such as intestines, liver, gastric, breast, lung, ovary, prostate, brain glioma, lymph, skin, pigment, thyroid gland, multiple bone marrow cancer and leukemia.

Priority: CN20071056476 Applic. Date: 2007-01-18; WO2007CN00390 Applic. Date: 2007-02-05

Inventor: ZHANG HESHENG [CN]

 

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US PROVISIONAL PATENT APPLICATIONS IN SKIN CARE ACTIVES PUBLISHED IN 2009
This list includes Provisional Patent Applications published in the United States. The list was retrieved by searching the claims section of all patent applications published. Salient search
terms include skin care active ingredients having properties such as anti-ageing, anti-wrinkle, antioxidant, acne control benefits, skin whitening or lightening, blemish removal, etc. This
category includes technology related to the synthesis and delivery of actives such as peptides, exfoliants, α-hydroxy acids, herbals, free radical scavengers, "green" derived molecules and
compounds having unique sensory properties.
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