US Patent Applications in Skin Care Actives and Formulations Published in 2008

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US PATENT APPLICATIONS IN SKIN CARE ACTIVES PUBLISHED IN 2008



Application No.: US20080002882A1  Published: 03/Jan/2008

Title: Brand protection and product autentication using portable devices

Applicant/Assignee:

Application No.: 11/477486   Filing Date: 30/Jun/2006

Abstract:The present invention is a method and apparatus for protection of products and packaging against counterfeiting using dedicated authentication protocol coupled with portable devices. It is based on the product identification information, i.e., PIN, generated by the product manufacturer, stored in the product database and added to product or packaging in an open and/or a hidden form. The open part is directly available to the consumer before buying, opening or consuming the product or package or damaging its integrity while the hidden part is only revealed after these operations. The hidden information can also be disappearing after a predefined interval of time or number of trials or usages. Both parts are communicated to the authentication server in a predefined order to verify the product or package authenticity. The presence, absence, or multiple requests for the same product PIN, confirm or reject product authenticity or detect attempt at attacking the system or at using counterfeited products.

Priority:

Inventor: VOLOSHYNOVSKYY SVYATOSLAV [CH]; KOVAL OLEKSIY [CH]; PUN THIERRY [CH]


Application No.: US20080003190A1  Published: 03/Jan/2008

Title: Antibacterial botanicals

Applicant/Assignee:

Application No.: 11/821288   Filing Date: 22/Jun/2007

Abstract:A method is disclosed for the preparation of an antimicrobial botanical active from a natural plant. The method comprises the steps of: (a) selecting a plant from the group consisting of: Allspice (Pimenta diocia), Applephenon(R), a commercially available green apple extract (Nikka Whisky Distillery, Ashai Breweries Ltd, Tokyo, JP), ripe autumn olive berry (Eleagnus umbelifera), dried "Baes pepper korns from the Island of Guadalupe, commercially available cinnamon powder, commercially available cocoa powder, cloves (Syzgium aromaticum), corn tassels (Zea mays), curly dock seeds (Rumex crispus), dried hops leaves (Humulus lupulus), dried Lavender flowers (Lavendula provence), Linden tree catkin (Tilia americana), dried Oak tree catkins (Quercus alba), dried Oregano leaves (Origanum vulgare), chinese Prickly Ash (Pericarpium zanthoxylli), and commercially available dried green tea leaves (Camellia sinensis)

and (b) forming a natural botanical extract from said plant in an amount effective for exerting at least one of the following properties and physiological actions on microbes: (1) inhibiting the growth of gram-positive and gram-negative microorganisms, and (2) inhibiting the growth of yeast and fungi.

Priority: US20060817918P Applic. Date: 2006-07-03

Inventor: WILLE JOHN J JR [US]


Application No.: US20080003191A1  Published: 03/Jan/2008

Title: Composition combining a C-glycoside derivative and an emulsifying polymer

Applicant/Assignee: L'OREAL

Application No.: 11/822107   Filing Date: 02/Jul/2007

Abstract:The present invention relates to a cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium, at least one C-glycoside derivative and at least one emulsifying polymer chosen from polyolefins containing polar portion(s) and amphiphilic polymers comprising at least one acrylamido-2-methylpropanesulfonic acid (AMPS) unit.

Priority: FR20060006023 Applic. Date: 2006-07-03; US20060836390P Applic. Date: 2006-08-09

Inventor: SIMONNET JEAN-THIERRY [FR]; CHEVALIER VERONIQUE [FR]


Application No.: US20080003192A1  Published: 03/Jan/2008

Title: Functional compositions containing cationic hydrophobically modified polysaccharides for personal care, household & institutional and pet care products

Applicant/Assignee:

Application No.: 11/824317   Filing Date: 29/Jun/2007

Abstract:This invention relates to functional compositions for use in personal care, household & institutional and pet care applications and which contain cationic hydrophobically modified polysaccharides thereby permitting a reduction in the amount of active ingredient material present in the functional composition over amounts typically found in conventional functional compositions while substantially maintaining the level of performance of the functional composition when compared to the level of performance of the conventional functional composition.

Priority: US20060817483P Applic. Date: 2006-06-29

Inventor: MODI JASHAWANT J [US]


Application No.: US20080003271A1  Published: 03/Jan/2008

Title: Compositions with Several Hyaluronic Acid Fractions for Cosmetic Use

Applicant/Assignee: NOVOZYMES BIOPOLYMER A/S

Application No.: 11/769141   Filing Date: 27/Jun/2007

Abstract:The present invention provides a moisturizing, cosmetic, or anti-wrinkle product comprising at least two hyaluronic acid fractions, or salts thereof, wherein a fraction has an average molecular weight in the range of 8,000-100,000 Da, and a fraction has an average molecular weight in the range of 100,000-500,000 Da.

Priority: DK20060000865 Applic. Date: 2006-06-28; DK20060000937 Applic. Date: 2006-07-07; US20060819683P Applic. Date: 2006-07-10; US20060817766P Applic. Date: 2006-06-29

Inventor: ABDELLAOUI KHADIJA S [DK]; MALLE BIRGITTE M [DK]


Application No.: US20080003277A1  Published: 03/Jan/2008

Title: Agent for improving tissue penetration

Applicant/Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSHAFTEN E.V GENZYME CORPORATION

Application No.: 11/716669   Filing Date: 12/Mar/2007

Abstract:The invention concerns a pharmaceutical preparation which improves penetration of active substances through the tissue membrane or barrier of the target organ.

Priority: DE20011022855 Applic. Date: 2001-05-11; US2003-477562 Applic. Date: 2003-11-12; WO2002EP05242 Applic. Date: 2002-05-13

Inventor: EIBL HANSJORG [DE]; HOFFMANN PETER [US]


Application No.: US20080003283A1  Published: 03/Jan/2008

Title: DIPEPTIDYL PEPTIDASE INHIBITORS

Applicant/Assignee: TAKEDA PHARMACEUTICAL COMPANY, INC TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 11/835295   Filing Date: 07/Aug/2007

Abstract:Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US2005-080992 Applic. Date: 2005-03-15; US20040553571P Applic. Date: 2004-03-15; US20040629524P Applic. Date: 2004-11-18

Inventor: FENG JUN [US]; GWALTNEY STEPHEN L [US]; STAFFORD JEFFREY A [US]; ZHANG ZHIYUAN [US]; ELDER BRUCE J [US]; ISBESTER PAUL K [US]; PALMER GRANT J [US]; SALSBURY JONATHAN S [US]; ULYSSE LUCKNER [US]


Application No.: US20080004246A1  Published: 03/Jan/2008

Title: Transporter enhanced corticosteroid activity

Applicant/Assignee:

Application No.: 11/802403   Filing Date: 22/May/2007

Abstract:Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl 17alpha-alkoxycarbonyloxy-11beta-hydroxyandrost-4-en-3-one-17beta-carboxylate type and the corresponding Delta<1,4>-compounds are described. The enhancing agents have the formula: wherein Z1 is carbonyl, beta-hydroxymethylene or methylene

R2 is H, -OH or -OCOR3 wherein R3 is C1-C5 alkyl

Y is -OH, -SH or -OCOR4 wherein R4 is C1-C5 alkyl, cyclopentylethyl or diethylaminoethyl

and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated.

Priority: US20060808118P Applic. Date: 2006-05-25

Inventor: BODOR NICHOLAS S [US]


Application No.: US20080004329A1  Published: 03/Jan/2008

Title: Pharmaceutical compositions of ropinirole and methods of use thereof

Applicant/Assignee: JAZZ PHARMACEUTICALS

Application No.: 11/823028   Filing Date: 26/Jun/2007

Abstract:The present invention comprises compositions for pharmaceutical drug delivery of an indolone (e.g., ropinirole), or a pharmaceutically acceptable salt thereof. The composition may, for example, be a gel suitable for transdermal application. The compositions of the present invention typically comprise a hydroalcoholic vehicle, one or more antioxidant, and one or more buffering agent, wherein the pH of the gel is usually between about pH 7 and about pH 9. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional solvent(s), antioxidant(s), cosolvent(s), penetration enhancer(s), buffering agent(s), and/or gelling agent(s). The compositions may be used for the treatment of a variety of neurological disorders.

Priority: US20060817259P Applic. Date: 2006-06-29

Inventor: JAMIESON GENE [US]; CARRARA DARIO NORBERTO [CH]; GRENIER ARNAUD [FR]


Application No.: US20080008669A1  Published: 10/Jan/2008

Title: Photostable sunscreen compositions comprising cinnamate ester UV-B filters and s-triazine compounds

Applicant/Assignee: L'OREAL

Application No.: 11/702167   Filing Date: 05/Feb/2007

Abstract:Photostable sunscreen compositions containing at least one cinnamic acid ester UV-B filter and at least one particular s-triazine compound have improved effectiveness with respect to UV-B radiation.

Priority: FR20060050392 Applic. Date: 2006-02-03; US20060773656P Applic. Date: 2006-02-16

Inventor: RICHARD HERVE [FR]; CANDAU DIDIER [FR]


Application No.: US20080008673A1  Published: 10/Jan/2008

Title: Compositions comprising at least one C-glycoside derivative

Applicant/Assignee:

Application No.: 11/822060   Filing Date: 02/Jul/2007

Abstract:The present disclosure relates to the combination of at least one C-glycoside derivative with at least one additional cosmetic or dermatological ingredient and/or active agent. Disclosed herein are cosmetic and/or dermatological compositions containing such a combination in a physiologically acceptable medium, or alternatively, a cosmetic or dermatological assembly comprising at least two separate compositions respectively containing for one the C-glycoside derivative and for the other the cosmetic or dermatological ingredient and/or active agent. Also disclosed is a cosmetic treatment method for caring for, cleansing and/or making up the skin and/or its appendages using the combination or the composition(s) according to the invention.

Priority: US20060817683P Applic. Date: 2006-07-03

Inventor: WILLEMIN CLAUDIE [FR]; BISSEY-BEUGRAS LAURE [FR]; SENEE JEROME [FR]


Application No.: US20080008674A1  Published: 10/Jan/2008

Title: Use of C-glycoside derivative for improving the skin's barrier function

Applicant/Assignee: L'OREAL

Application No.: 11/822114   Filing Date: 02/Jul/2007

Abstract:The present invention relates to a cosmetic method for improving and/or reinforcing the skin's barrier function comprising at least a step of applying to the skin a composition comprising at least one C-glycoside derivative.

Priority: FR20060006025 Applic. Date: 2006-07-03; US20060836659P Applic. Date: 2006-08-10

Inventor: BURNIER VERONIQUE [FR]; BESNE ISABELLE [FR]


Application No.: US20080008677A1  Published: 10/Jan/2008

Title: COMPOSITIONS COMPRISING AT LEAST ONE ORGANIC POLYMER AND A MIXTURE OF VOLATILE AND NONVOLATILE SOLVENTS

Applicant/Assignee: L'OREAL

Application No.: 11/858633   Filing Date: 20/Sep/2007

Abstract:Compositions, for example cosmetic compositions, comprising at least one organic polymer, such as a crosslinked organosoluble polymer, and a mixture of at least two solvents, one of which is volatile and incompatible with the polymer, and the other of which is nonvolatile and compatible with the polymer. These compositions make it possible to form on keratin materials a deposit whose volume increases over time, without the intervention of an external stimulus. These compositions can be, for example, mascaras, lipsticks or anti-wrinkle formulas in the form of a cream or a foundation. The cosmetic treatment processes using these compositions.

Priority: FR19990009265 Applic. Date: 1999-07-16; US2003-621534 Applic. Date: 2003-07-17; US2000-618031 Applic. Date: 2000-07-17

Inventor: FERRARI VERONIQUE [FR]; TOURNILHAC FLORENCE [FR]


Application No.: US20080008727A1  Published: 10/Jan/2008

Title: Compositions comprising adapalene dissolved with cyclodextrins

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 11/812889   Filing Date: 22/Jun/2007

Abstract:Cosmetic/pharmaceutical compositions comprising adapalene dissolved in an aqueous medium with cyclodextrin and/or derivatives thereof, notably as inclusion complexes therewith, are useful as cosmetics and for the therapeutic treatment, e.g., of acne.

Priority: FR20040013760 Applic. Date: 2004-12-22; WO2005FR03173 Applic. Date: 2005-12-16

Inventor: FREDON LAURENT [FR]; ORSONI SANDRINE [FR]; FERRANDIS AGNES [FR]; MALLARD CLAIRE [FR]


Application No.: US20080008748A1  Published: 10/Jan/2008

Title: METHOD FOR TREATING PAIN USING A SUBSTITUTED 2-AMINOTETRALIN COMPOUND

Applicant/Assignee:

Application No.: 11/764907   Filing Date: 19/Jun/2007

Abstract:A method for treating pain, particularly non-inflammatory musculoskeletal pain such as fibromyalgia, myofascial pain or back pain, in a subject comprises administering to the subject a substituted 2-aminotetralin compound as defined herein, illustratively rotigotine.

Priority: EP20060012815 Applic. Date: 2006-06-22

Inventor: BEYREUTHER BETTINA [DE]; SCHELLER DIETER [DE]; FREITAG JOACHIM [DE]; BIANCHINE JOSEPHE [US]


Application No.: US20080009453A1  Published: 10/Jan/2008

Title: Pharmceutical Compositions Containing Polydatin or Its Salts and Their Application

Applicant/Assignee: SHENZHEN NEPTUNUS PHARMACEUTICAL CO., LTD

Application No.: 10/492405   Filing Date: 04/Aug/2003

Abstract:The invention discloses pharmaceutical compositions containing polydatin or its pharmaceutically acceptable salts with the effect of improving microcirculation, and their application in preparing drugs which can improve microcirculation. The compositions are an non-gastrointestinal injection preparation, the preparation can be an aqueous solution which have pH 7.0-10.0 comprising 5-50% propandiol. The dosage forms of the compositions may be lyophilizing powder injection, oral form, suppository of procto-administration and other forms of administrations comprising unguent, ointment, paste film coating and the like. The compositions may be used to treat and/or prevent diseases related to microcirculation blockage. The unit form may contain 1-1000 mg polydatin or its derivatives. The invention solves the problem of using polydatin to improve microcirculation. The composition of the invention can be used in treating shock, cardiac and cerebrovascular diseases, diseases of sense organs, diabetes complication, vaculitis related to blockage of blood vessel, hemorrhoid related to circulation obstruction, skin injury and burn.

Priority: CN20021034928 Applic. Date: 2002-10-08; WO2003CN00621 Applic. Date: 2003-08-04

Inventor: ZHAO JINHUA [CN]; KANG HUI [CN]; ZHAO KESEN [CN]; HUANG XULIANG [CN]; ZHAO GUILING [CN]; LI JING [CN]; FENG HANLIN [CN]; YAO GUANGHUI [CN]; YAO QIAN [CN]; LIN SHENGZHAO [CN]; ZHOU QI [CN]


Application No.: US20080009550A1  Published: 10/Jan/2008

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORP

Application No.: 11/901423   Filing Date: 17/Sep/2007

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain dialkylhydroxyamine stabilizers, dialkylhydroxylamine stabilizer salts, nitrone stabilizers or amine oxide stabilizers. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US2004-970112 Applic. Date: 2004-10-21; US20030515889P Applic. Date: 2003-10-30

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MERVIN G [US]


Application No.: US20080009802A1  Published: 10/Jan/2008

Title: Method of treating acne with stratum corneum piercing device

Applicant/Assignee:

Application No.: 11/113937   Filing Date: 25/Apr/2005

Abstract:The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device including a microprotrusion member having a skin-contacting surface and plurality of stratum corneum-piercing microprotrusions thereon.

Priority:

Inventor: LAMBINO DANILO [AU]; LIU JUE-CHEN [US]; SUN YING [US]; MCDONOUGH JUSTIN [US]; WU JEFFREY M [US]; MAGHRIBI MARIAM [US]


Application No.: US20080014160A1  Published: 17/Jan/2008

Title: Antiperspirant Gel Compositions

Applicant/Assignee:

Application No.: 11/856322   Filing Date: 17/Sep/2007

Abstract:The present invention relates to antiperspirant compositions comprising a cationic hydrophobically modified polymeric gelling agent and an acidic antiperspirant compound. The antiperspirant compositions are transparent, phase stable, non-whitening and non-staining to the skin and clothing following topical application. The present invention also is directed to methods of using the antiperspirant compositions.

Priority: US2003-646856 Applic. Date: 2003-08-22; US20060845541P Applic. Date: 2006-09-18

Inventor: FAIVRE DAVID [BE]; PUROHIT PINKY G [US]; TAMARESELVY KRISHNAN [US]; KRZYSIK DUANE G [US]; GHIRARDI DORINA [BE]; SUARES ALAN J [US]


Application No.: US20080014162A1  Published: 17/Jan/2008

Title: Method to treat skin in need of a calmative using at least one C-Glycoside derivative

Applicant/Assignee: L'OREAL

Application No.: 11/822160   Filing Date: 02/Jul/2007

Abstract:The present invention concerns a non-therapeutic method to prevent and/or treat a skin in need of a calmative using a C-glycoside derivative.

Priority: FR20060006015 Applic. Date: 2006-07-03; US20060836391P Applic. Date: 2006-08-09

Inventor: WILLEMIN CALUDIE [FR]; BURNIER VERONIQUE [FR]


Application No.: US20080014169A1  Published: 17/Jan/2008

Title: Compositions for Topical Enzymatic Debridement

Applicant/Assignee: COLLEGIUM PHARMACEUTICAL, INC

Application No.: 11/843158   Filing Date: 22/Aug/2007

Abstract:Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

Priority: US2005-147567 Applic. Date: 2005-06-08; US20050642835P Applic. Date: 2005-01-11; US20040608991P Applic. Date: 2004-09-10; US20040604900P Applic. Date: 2004-08-27; US20040580085P Applic. Date: 2004-06-16

Inventor: TRUMBORE MARK W [US]; RARIY ROMAN V [US]; HIRSH MARK [US]; HIRSH JANE C [US]; SAUNDERS JULIE A [US]


Application No.: US20080014180A1  Published: 17/Jan/2008

Title: Hemangio-colony forming cells

Applicant/Assignee:

Application No.: 11/787262   Filing Date: 13/Apr/2007

Abstract:Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.

Priority: US20060792224P Applic. Date: 2006-04-14; US20060801993P Applic. Date: 2006-05-19; US20060846163P Applic. Date: 2006-09-20; US20060852142P Applic. Date: 2006-10-16; US20060860676P Applic. Date: 2006-11-22; US20070918832P Applic. Date: 2007-03-19

Inventor: LANZA ROBERT [US]; LU SHI-JIANG [US]


Application No.: US20080014224A1  Published: 17/Jan/2008

Title: Methods of Making Compositions Comprising Films

Applicant/Assignee:

Application No.: 11/457610   Filing Date: 14/Jul/2006

Abstract:The invention relates to methods of making films having active ingredients. A film that is substantially free of active ingredient is introduced into a medium comprising an active ingredient. At least a portion of the active ingredient is transferred from the medium to the film. The films can be used in a variety of applications, including oral care, personal care, cleansing and/or home care compositions.

Priority:

Inventor: BOYD THOMAS J [US]; DILLON RENSL [US]; MILLER JEFFREY M [US]; VISCIO DAVID B [US]; GAFFAR ABDUL [US]


Application No.: US20080014231A1  Published: 17/Jan/2008

Title: Treatment articles capable of delivering intensive care and overall treatment simultaneously

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/827939   Filing Date: 13/Jul/2007

Abstract:The present invention relates to treatment articles capable of delivering intensive care and overall care simultaneously. The articles comprise a first substrate, a second substrate which substantially covers the first substrate at-use, a first treatment composition and a second treatment composition wherein the delivery of the skin care active to the skin is initiated by the treatment composition. The articles also comprises a first substrate which contains a first treatment composition, a second substrate which substantially cover the first substrate at-use and a treatment composition wherein delivery of the first treatment composition is initiated by the second treatment composition. Preferred articles of the present invention comprise facial treatment masks.

Priority: US20060831106P Applic. Date: 2006-07-14

Inventor: OKANO TOSHIHIKO [JP]


Application No.: US20080014232A1  Published: 17/Jan/2008

Title: TWO-COAT MAKE-UP PRODUCT, ITS USE AND A KIT CONTAINING THE MAKE-UP PRODUCT

Applicant/Assignee: L'OREAL

Application No.: 11/829362   Filing Date: 27/Jul/2007

Abstract:A cosmetic make-up product containing a first and a second composition, the first composition comprising, in a physiologically acceptable medium, dispersed polymer particles surface-stabilized with a stabilizer in a liquid organic phase and a coloring agent, and the second composition comprising a second physiologically acceptable medium.

Priority: FR20010004938 Applic. Date: 2001-04-10; FR20020001438 Applic. Date: 2002-02-06; US2005-044180 Applic. Date: 2005-01-28; US2002-118962 Applic. Date: 2002-04-10; US20010293982P Applic. Date: 2001-05-30

Inventor: ARNAUD PASCAL [FR]; LE CHAUX LAURE [FR]; FERRARI VERONIQUE [FR]; LEBRE CAROLINE [FR]


Application No.: US20080014250A1  Published: 17/Jan/2008

Title: Bifunctionalized polysaccharides

Applicant/Assignee: PROTEINS AND PEPTIDES MANAGEMENT

Application No.: 11/783402   Filing Date: 09/Apr/2007

Abstract:The present invention relates to a dextran and/or dextran derivative bifunctionalized by at least one imidazolyl radical Im and at least one hydrophobic group Hy, the said radical and the said group being each identical and/or different and grafted or bonded to the dextran and/or dextran derivative via one or more connecting arms R, Ri or Rh and functional groups F, Fi or Fh and the pharmaceutical compositions comprising one of the said dextrans and at least one active principle.

Priority: FR20060003130 Applic. Date: 2006-04-07; US20060790532P Applic. Date: 2006-04-10

Inventor: SOULA GERARD [FR]; SOULA REMI [FR]; SOULA OLIVIER [FR]


Application No.: US20080014393A1  Published: 17/Jan/2008

Title: Functionalized substrates comprising perfume microcapsules

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/895602   Filing Date: 24/Aug/2007

Abstract:An article comprising: a functionalized substrate comprising: a composition susceptible to aqueous attack, comprising a water-soluble material, a partially water soluble material, a water-dispersible materials, a water-disintegrating materials, and mixtures thereof

a plurality of microcapsules encapsulating a perfume, wherein said plurality of microcapsules is incorporated with said functionalized substrate

and a total perfume loading level of from about 1% to about 95% by weight of said functionalized substrate.

Priority: US2007-800616 Applic. Date: 2007-05-07; US20060798158P Applic. Date: 2006-05-05

Inventor: DENOME FRANK W [US]; BERGES-CABRERA TANIA E [US]; WAHL ERROL H [US]; BROWN JODI L [US]; FOSSUM RENAE D [US]; CATALFAMO VINCENZO [US]; GIZAW YONAS [US]; BOEKLEY LOIS J [US]


Application No.: US20080015200A1  Published: 17/Jan/2008

Title: Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor

Applicant/Assignee: JANSSEN PHARMACEUTICA N.V

Application No.: 11/827354   Filing Date: 10/Jul/2007

Abstract:Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Priority: US20060830192P Applic. Date: 2006-07-11

Inventor: CHAVEZ FRANK [US]; CURTIS MICHAEL P [US]; EDWARDS JAMES P [US]; GOMEZ LAURENT [US]; GRICE CHERYL A [US]; KEARNEY AARON M [US]; SAVALL BRAD M [US]


Application No.: US20080015202A1  Published: 17/Jan/2008

Title: Thiazole Derivatives Having Vap-1 Inhibitory Activity

Applicant/Assignee: ASTELLAS PHARMA INC

Application No.: 11/574946   Filing Date: 08/Sep/2005

Abstract:A compound of the formula (I): U-V-W-X-Y-Z (I) wherein U is lower alkyl

V is -CONH- or -NR<1>CO- wherein R<1 >is a hydrogen or lower alkyl

W is a bond or lower alkylene

X is a bivalent residue derived from optionally substituted thiazole

Y is a bond or lower alkylene

and Z is a group of the formula: wherein R<2 >is a group of the formula: -A-B-D-E-F-G wherein A is a bond or lower alkylene

B is a bond, -NH- or D is a bond, -CS- or -CO-

E is a bond or -NH-

F is a bond, -CO-, -O- or -SO2-

and G is lower alkyl, optionally protected amino, -OH, phenyl, R<3 >is lower alkyl, provided that when Z is a group of the formula: then G should not be amino, when Z is a group of the formula: then G should not be when Z is a group of the formula: and G is optionally protected amino, then D should be -CS-, or then A should be lower alkylene, B or E should be -NH- and F should be -CO-

or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor as well as a pharmaceutical composition and a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

Priority: AU20040905183 Applic. Date: 2004-09-09; WO2005JP16984 Applic. Date: 2005-09-08

Inventor: INOUE TAKAYUKI [JP]; TOJO TAKASHI [JP]; MORITA MASATAKA [JP]


Application No.: US20080015271A1  Published: 17/Jan/2008

Title: Fatty acid pharmaceutical foam

Applicant/Assignee: STIEFEL RESEARCH AUSTRIALIA PTY LTD

Application No.: 11/826199   Filing Date: 12/Jul/2007

Abstract:The present invention provides a foamable composition comprising water and an organic solvent, wherein the organic solvent comprises a fatty acid. The composition may further comprise a pharmaceutically active agent. The composition of the invention is also useful for the treatment of a dermatological disorder in a mammal by the topical administration of the composition.

Priority: US20060830949P Applic. Date: 2006-07-14

Inventor: ABRAM ALBERT Z [AU]; GOLDSTEIN IULIAN [AU]


Application No.: US20080019930A1  Published: 24/Jan/2008

Title: Dibenzoylmethane sunscreens photostabilized with arylalkyl amide or ester compounds

Applicant/Assignee: L'OREAL

Application No.: 11/819037   Filing Date: 25/Jun/2007

Abstract:Improvedly effective and photostable sunscreen compositions combine a dibenzoylmethane screening agent and a specific arylalkyl amide or ester compound of the following formulae (I), (II) or (III):

Priority: FR20060052621 Applic. Date: 2006-06-23; FR20060052620 Applic. Date: 2006-06-23; US20060819638P Applic. Date: 2006-07-11; US20060819637P Applic. Date: 2006-07-11

Inventor: CANDAU DIDIER [FR]; LUCET-LEVANNIER KARINE [FR]


Application No.: US20080019957A1  Published: 24/Jan/2008

Title: TOPICALLY APPLIED PROBUCOL-CONTAINING AGENT WITH PROTECTIVE AND REGENERATIVE EFFECT

Applicant/Assignee:

Application No.: 11/780662   Filing Date: 20/Jul/2007

Abstract:A method of treating skin changes and conditions in human skin including applying a topical preparation that includes an active agent including probucol, a derivative of probucol or a combination of probucol and a derivative of probucol.

Priority: US20060807899P Applic. Date: 2006-07-20

Inventor: NEUDECKER BIRGIT [DE]; DIEDRICH FALKO [DE]; WIELAND EBERHARD [DE]


Application No.: US20080019975A1  Published: 24/Jan/2008

Title: Novel Regimens for Treating Diseases and Disorders

Applicant/Assignee: BIOASSETS DEVELOPMENT CORPORATION

Application No.: 11/775206   Filing Date: 09/Jul/2007

Abstract:Methods and materials are provided for induction-maintenance regimens of targeted anti-inflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred embodiments include administration of one or more TATs using an induction regimen comprising a lower dose per administration administered by a more invasive and/or more localized route, followed by administration of one or more TATS using a maintenance regimen, comprising a higher dose per administration administered by a less invasive and/or less localized route.

Priority: US20060847493P Applic. Date: 2006-09-27; US20060819555P Applic. Date: 2006-07-07

Inventor: GORMAN JAMES R [US]


Application No.: US20080020000A1  Published: 24/Jan/2008

Title: Clostridium botulinum c3 exotransferase compositions and methods for treating tumour spreading

Applicant/Assignee: BIOAXONE THERAPEUTIQUE

Application No.: 10/573658   Filing Date: 29/Sep/2004

Abstract:Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a cancer in a mammal. The compositions can each effect or arrest combination of two or more of tumor cell proliferation, migration, angiogenesis, and metalloproteinase secretion.

Priority: US2004-902878 Applic. Date: 2004-08-02; US20030506162P Applic. Date: 2003-09-29; WO2004CA01763 Applic. Date: 2004-09-29

Inventor: MCKERRACHER LISA [CA]


Application No.: US20080020028A1  Published: 24/Jan/2008

Title: TRANSDERMAL DOSAGE FORM COMPRISING AN ACTIVE AGENT AND A SALT AND A FREE-BASE FORM OF AN ADVERSE AGENT

Applicant/Assignee: EURO-CELTIQUE S.A

Application No.: 11/865387   Filing Date: 01/Oct/2007

Abstract:This invention relates to a tamper-resistant transdermal dosage form comprising an active agent, such as an opioid, or a pharmaceutically acceptable salt thereof, a free base of an adverse agent, such as an opioid antagonist, and a pharmaceutically acceptable salt of an adverse agent, such as an opioid antagonist. The transdermal dosage form allows an effective amount of the active agent, or a pharmaceutically acceptable salt thereof, to be transdermally administered to an animal. The invention further relates to methods for treating or preventing pain in an animal comprising contacting the skin of an animal in need thereof with the transdermal dosage form of the invention for an amount of time sufficient to treat or prevent pain.

Priority: US2003-645654 Applic. Date: 2003-08-20

Inventor: SHEVCHUK IHOR [US]; REIDENBERG BRUCE [US]


Application No.: US20080020067A1  Published: 24/Jan/2008

Title: Skin Moisturizer

Applicant/Assignee:

Application No.: 10/594900   Filing Date: 31/Mar/2005

Abstract:The present invention provides an oral skin moisturizer that is readily available to those who are suffering from dry skin, has no side effects, and when orally ingested, enhances the moisture-retaining ability of the skin. The invention also provides food products or the like that contain the oral skin moisturizer. Specifically, the oral skin moisturizer contains, as an active ingredient, a extract of a plant of the genus Lepidium of the family Cruciferae. More specifically, the oral skin moisturizer contains as an active ingredient a extract of maca (Lepidium meyenii Walp). Food products, liquors, functional food products, and pharmaceutical products containing the oral skin moisturizer are also provided.

Priority: JP20040101734 Applic. Date: 2004-03-31; WO2005JP06324 Applic. Date: 2005-03-31

Inventor: KODA HIROFUMI [JP]; KISO YOSHINOBU [JP]; MATSUMOTO TAKEHIRO [JP]


Application No.: US20080020073A1  Published: 24/Jan/2008

Title: USE OF OLIGOSACCHARIDES TO STIMULATE BETA-ENDORPHIN PRODUCTION

Applicant/Assignee:

Application No.: 11/841240   Filing Date: 20/Aug/2007

Abstract:The invention concerns the use of at least an oligosaccharide comprising 2 to 6 sugars and containing at least 2 galactose units, preferably 2 vicinal end-of-chain galactose motifs, or a plant extract containing same, as a cosmetic or dermatological agent, in particular for stimulating the beta-endorphin production in the skin. The invention enables to provide care for sensitive skins, in particular to fight against skin sensitivity, uncomfortable reactions, to provide sensations of well-being, and to produce a local analgesic action.

Priority: FR20000008879 Applic. Date: 2000-07-07; US2003-332136 Applic. Date: 2003-01-06; WO2001FR02154 Applic. Date: 2001-07-05

Inventor: BONTE FREDERIC [FR]; DUMAS MARC [FR]; LHERMITE STEPHANE [FR]; SAUNOIS ALEX [FR]


Application No.: US20080020976A1  Published: 24/Jan/2008

Title: ANTIMICROBIALLY ACTIVE PEPTIDE

Applicant/Assignee: EBERHARD-KARLS-UNIVERSITAET TUEBINGEN UNIVERSITAETSKILINIKUM

Application No.: 10/735481   Filing Date: 12/Dec/2003

Abstract:An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.

Priority: DE20011029983 Applic. Date: 2001-06-13; WO2002EP06238 Applic. Date: 2002-06-07

Inventor: GARBE CLAUS [DE]; SCHITTEK BIRGIT [DE]


Application No.: US20080020993A1  Published: 24/Jan/2008

Title: Regulation of cell proliferation and differentiation using topically applied nucleic acid molecules

Applicant/Assignee:

Application No.: 11/798438   Filing Date: 14/May/2007

Abstract:Methods are disclosed for the regulation of cell differentiation and proliferation, e.g., for treating hyperproliferative skin disorder, such as psoriasis, and skin cancer for enhancing wound healing, for stimulating hair growth and inhibiting hair growth, by administration of nucleic acid molecules encoding parathyroid hormone (PTI), parathyroid related peptide (PTHrP), or fragment, analog or derivative thereof, and salts thereof, encapsulated by particular liposomes or incorporated into a porous biocompatable matrix.

Priority: US2003-398449 Applic. Date: 2003-07-23; WO2001US31082 Applic. Date: 2001-10-05; US20000238134P Applic. Date: 2000-10-06

Inventor: HOLICK MICHAEL F [US]


Application No.: US20080020995A1  Published: 24/Jan/2008

Title: Use of Cyclodextrin Complexes Containing Lipoic Acid

Applicant/Assignee:

Application No.: 11/720350   Filing Date: 08/Aug/2005

Abstract:The invention relates to the use of cyclodextrin complexes containing lipoic acid, said complexes consisting of at least one representative of the series of unsubstituted alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin, and at least one representative of the series of racemic alpha-lipoic acid, racemic dihydrolipoic acid and the derivatives thereof, for producing a food supplement, a functional food supplement, a clinical nutrition product and/or a cosmetic preparation in the non-medical field of application. Said complex, which contains at least 20 wt. % of the cyclodextrin component, preferably in food quality, can also contain water and reaction products or secondary reaction products from the complex production, especially alpha-cyclodextrin being used. The cyclodextrin/(dihydro)liponic acid complexes can be used, preferably combined with other bioactive components, aromas and/or texturing products, and also the standard formulation auxiliary agents, to produce an agent for preventing and/or treating symptoms of an inflammatory nature and especially arthritis, damage to the liver function and especially alcohol intoxication, paraesthesiae and neuropathies, and for producing agents having cytoprotective and/or antiphlogistic and/or antinociceptive (analgesic) properties and/or properties that counteract the formation of radicals. Said complexes can also preferably be used to produce an agent for stimulating glucose metabolism and/or transport in muscles and/or lipocytes, agents for reinforcing the energy metabolism of the body and the brain, agents for increasing the endurance, capacity, attentiveness, concentration of the memory, agents for the prevention and/or treatment of diabetes Typ2, and agents for caring for at least partially keratinised parts of the body, especially the skin, hair, fingernails and toenails. The invention enables products to be obtained, which can be taken by the end consumer under improved compliance conditions in the non-medical field of indication, due to the distinctive stability of the agents.

Priority: DE200410060914 Applic. Date: 2004-12-17; WO2005EP08577 Applic. Date: 2005-08-08

Inventor: PURPURA MARTIN [DE]; SCHUTT WOLFGANG [DE]


Application No.: US20080021418A1  Published: 24/Jan/2008

Title: LIPOLYSIS STIMULATOR

Applicant/Assignee: KAO CORPORATION

Application No.: 11/782160   Filing Date: 24/Jul/2007

Abstract:The present invention is directed to a lipolysis stimulator and a slimming agent which stimulate or facilitate lipolysis of accumulated adipose tissue, to thereby exert the body slimming effect. The lipolysis stimulator or the slimming agent of the present invention contains as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca, polygala root, plantago herb, calumba, zuikorodoku, garden nasturtium, kidachiumanosuzukusa, bayberry, cogon grass, kohon, shoyokanzo, Japanese white birch, tanjin, kikubafuro, white mustard, common sunflower, ground ivy, Chinese wolfberry, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, fenugreek, English walnut, sozuku, koniwa-zakura, gardenia, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed.

Priority: JP20030203095 Applic. Date: 2003-07-29; JP20040156535 Applic. Date: 2004-05-26; US2004-900102 Applic. Date: 2004-07-28

Inventor: MORI SHINOBU [JP]; KUSUOKU HIROSHI [JP]; SATO MAYUMI [JP]


Application No.: US20080025930A1  Published: 31/Jan/2008

Title: Anti-aging Compositions Comprising Menyanthes Trifoliata Leaf Extracts and Methods of Use Thereof

Applicant/Assignee:

Application No.: 11/461093   Filing Date: 31/Jul/2006

Abstract:An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers of peroxynitrite. Also disclosed are methods of using such a composition, which include treating the skin for signs of chronological or pre-mature aging.

Priority:

Inventor: CORSTJENS HUGO [BE]; DECLERCQ LIEVE [BE]; SENTE ILSE [BE]; LOBSTEIN ANNELISE [FR]; WENIGER BERNARD [FR]; ANTON ROBERT [FR]


Application No.: US20080025931A1  Published: 31/Jan/2008

Title: Cosmetic method for limiting age-related hollowing of the face

Applicant/Assignee:

Application No.: 11/822162   Filing Date: 03/Jul/2007

Abstract:Disclosed herein is a cosmetic method for remodelling the face and/or limiting age-related hollowing of the face, by applying to the skin of the face and/or the neck, a composition containing, in a physiologically acceptable medium, at least one extract of a non-fruiting non-photosynthetic filamentous bacterium.

Priority: FR20060052782 Applic. Date: 2006-07-03; US20060830113P Applic. Date: 2006-07-12

Inventor: PELLETIER PASCALE [FR]; MARION CATHERINE [FR]


Application No.: US20080025932A1  Published: 31/Jan/2008

Title: Skin care compositions containing a sugar amine

Applicant/Assignee:

Application No.: 11/893184   Filing Date: 15/Aug/2007

Abstract:Topical skin care compositions containing sugar amines in combination with selected skin care actives and methods of using such compositions to regulate the condition of skin are disclosed. The compositions contain a safe and effective amount of a sugar amine in combination with either a safe and effective amount of a terpene alcohol and a safe and effective amount of a retinoid

a safe and effective amount of a terpene alcohol and a safe and effective amount of a peptide

a safe and effective amount of a retinoid and a safe and effective amount of a peptide

a safe and effective amount of tocopherol sorbate

or a safe and effective amount of a vitamin B3 compound.

Priority: US2006-412264 Applic. Date: 2006-04-27; US2002-097716 Applic. Date: 2002-03-13; US20010277805P Applic. Date: 2001-03-22

Inventor: BISSETT DONALD L [US]; GOODMAN LAURA J [US]; JEWELL-MOTZ ELIZABETH A [US]


Application No.: US20080025940A1  Published: 31/Jan/2008

Title: Administration of 3-sulfanylpropanamide compounds for stimulating hair and eyelash growth and/or for stopping the loss and/or limiting the depigmentation thereof

Applicant/Assignee: L'OREAL

Application No.: 11/882331   Filing Date: 31/Jul/2007

Abstract:3-Sulfanylpropanamide compounds of formula (I) or salts and/or solvates thereof: are useful for caring for and/or making up keratin fibers, especially human keratin fibers, to induce and/or stimulate the growth, to stop the loss and/or to increase the density thereof, and/or to improve the appearance and/or to reduce the canities thereof, and/or to stimulate the pigmentation and/or to limit the depigmentation and/or bleaching thereof.

Priority: FR20050050279 Applic. Date: 2005-01-31; WO2006EP01545 Applic. Date: 2006-01-23

Inventor: BRETON PHILIPPE [FR]; BOULLE CHRISTOPHE [FR]


Application No.: US20080025941A1  Published: 31/Jan/2008

Title: Compositions containing quaternary ammonium compounds

Applicant/Assignee: NOVAGALI PHARMA SA

Application No.: 11/822603   Filing Date: 09/Jul/2007

Abstract:This invention relates to compositions containing quaternary ammonium compounds in which the nitrogen atom is substituted by at least one alkyl group having at least 12 carbon atoms, characterized in that said composition includes at least 20% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 14 carbon atoms and more than 5%, preferably more than 7% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 16 carbon atoms. This invention also relates to ophthalmic oil-in-water emulsions containing such compositions, said ophthalmic emulsions being useful for eye care or for the treatment of eye conditions.

Priority: US2006-494493 Applic. Date: 2006-07-28

Inventor: RABINOVICH-GUILATT LAURA [FR]; LAMBERT GREGORY [FR]; LALLEMAND FREDERIC [FR]; PHILIPS BETTY [FR]


Application No.: US20080026013A1  Published: 31/Jan/2008

Title: Compositions containing quaternary ammonium compounds

Applicant/Assignee:

Application No.: 11/494493   Filing Date: 28/Jul/2006

Abstract:This invention relates to compositions containing quaternary ammonium compounds in which the nitrogen atom is substituted by at least one alkyl group having at least 12 carbon atoms, characterized in that the composition includes at least 20% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 14 carbon atoms and more than 5%, preferably more than 7% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 16 carbon atoms. This invention also relates to ophthalmic oil-in-water emulsions containing such compositions, said ophthalmic emulsions being useful for eye care or for the treatment of eye conditions.

Priority:

Inventor: RABINOVICH-GUILATT LAURA [FR]; LAMBERT GREGORY [FR]; LALLEMAND FREDERIC [FR]; PHILIPS BETTY [FR]


Application No.: US20080026014A1  Published: 31/Jan/2008

Title: Nasal Stick for the Application of Medicaments and Skin Care Substances

Applicant/Assignee:

Application No.: 10/532460   Filing Date: 31/Oct/2003

Abstract:A stick for the topical or transmucosal application of a skin care or active agent onto and via the nasal mucosa, respectively, is provided, wherein the stick material contains a composition of at least one carrier substance and at least one skin care or active agent, which is capable of acting on the nasal mucosa and/or being resorbed by it or which contains at least one volatile substance that acts on the deeper respiratory tract and/or is being resorbed by the deeper respiratory tract. Furthermore, the use of a medical skin care or cosmetical stick or of a stick material or of a refill cartridge containing said material for the topical or transmucosal application is described.

Priority: DE20021050944 Applic. Date: 2002-10-31; WO2003EP12150 Applic. Date: 2003-10-31

Inventor: MICHEL OLAF [DE]


Application No.: US20080027018A1  Published: 31/Jan/2008

Title: Electrotransfer of nucleic acid into tissue cells

Applicant/Assignee:

Application No.: 11/514354   Filing Date: 01/Sep/2006

Abstract:The electrotransfer of a nucleic acid into tissue cells, in particular in a muscle or a tumoral tissue, is carried out by an electric stimulation of the tissue as follows: first with at least one, preferably a single, pulse of a High Voltage field strength of between 200 and 2000 volts/cm second with a single pulse of Low Voltage field strength of between 50 and 200 volts/cm and of duration of between 300 ms and 2000 ms.

Priority: EP20050291825 Applic. Date: 2005-09-02; US20050713623P Applic. Date: 2005-09-02

Inventor: MIR LUIS [FR]; MIKLAVCIC DAMIJAN [SI]


Application No.: US20080027033A1  Published: 31/Jan/2008

Title: Method and Composition for Treatment of Cutaneous Lesions

Applicant/Assignee: ACRUX DDS PTY LTD

Application No.: 10/579756   Filing Date: 19/Nov/2004

Abstract:A method of treatment or prophylaxis of a cutaneous lesion in an animal the method comprising topically applying to an area of skin of the animal a composition comprising: one or more metal chelators

one or more transforming growth factor modulators

and one or more dermal penetration enhancers.

Priority: US20030523138P Applic. Date: 2003-11-19; WO2004AU01609 Applic. Date: 2004-11-19

Inventor: GONDA IGOR [AU]; MORGAN TIMOTHY MATTHIAS [AU]; WILKINS NINA FRANCES [AU]


Application No.: US20080027094A1  Published: 31/Jan/2008

Title: Tropane Compounds and Pharmaceutical Compositions Comprising the Same as an Active Ingredient

Applicant/Assignee: ONO PHARMACEUTICAL CO., LTD

Application No.: 11/661310   Filing Date: 29/Aug/2005

Abstract:The conventional anticholinergic drugs for administration through inhalation have been considered to have the possibility of aggravating dysuria associated with prostatic hyperplasia mediated by blood, and it has been demanded that the conventional anticholinergic drugs for administration through inhalation will have to show reduced side effects or adverse reactions. The present invention relates to a compound represented by the general formula (I): (wherein A represents

and R<1>, R<2>, R<3 >and R<1 >each a hydrogen atom or a substituent

R<5 >is a substituent

X<-> is an anion

the symbol: denotes an exo-form or endo-form, or their mixture), its salt or solvation product thereof. They are useful as a prophylactic and/or therapeutic agent with reduced side effects or adverse reactions for the diseases mediated by the muscarinic receptor.

Priority: JP20040250284 Applic. Date: 2004-08-30; JP20050023439 Applic. Date: 2005-01-31; JP20050196926 Applic. Date: 2005-07-06; WO2005JP15659 Applic. Date: 2005-08-29

Inventor: NAKAI HISAO [JP]; NISHIYAMA TOSHIHIKO [JP]; NAKAMURA NOBUYUKI [JP]; FUJITA MANABU [JP]


Application No.: US20080027365A1  Published: 31/Jan/2008

Title: HEMOSTATIC DEVICE WITH OXIDIZED CELLULOSE PAD

Applicant/Assignee:

Application No.: 11/754592   Filing Date: 29/May/2007

Abstract:In one aspect, an apparatus for promoting hemostasis includes oxidized cellulose in the form of a compressible, shapeable mass that is formed into a sheet for placement on a bleed site. In a second aspect, a sleeve for promoting hemostasis includes a tubular shell having at least one open end and oxidized cellulose material attached to an inner surface of the tubular shell. The open end of the tubular shell is dimensioned to receive a limb such that donning the sleeve causes at least a portion of the oxidized cellulose material to be placed in contact with a bleeding wound. In a third aspect, a bandage includes a substrate and oxidized cellulose material attached to a surface of the substrate. The oxidized cellulose material is arranged to contact a bleeding wound when the bandage is applied thereto.

Priority: US20060810447P Applic. Date: 2006-06-01

Inventor: HUEY RAYMOND J [US]


Application No.: US20080029121A1  Published: 07/Feb/2008

Title: Sheet structure having at least one colored surface

Applicant/Assignee: L'OREAL

Application No.: 11/790403   Filing Date: 25/Apr/2007

Abstract:The present invention relates to a sheet structure for application to a region of the human body, including the face, the structure comprising: a colored matrix

a first substrate situated on a first side of the matrix, a first surface of the sheet structure being defined by the first substrate

and a second substrate situated on a second side of the matrix, opposite the first, a second surface of the sheet structure being defined by the second substrate

the first and second substrates having different opacities, and at least one of the first and second substrates having an opacity that is low enough to enable the subjacent colored matrix to show through in such a manner that the first and second surfaces of the matrix appear to be of different colors.

Priority: FR20060051463 Applic. Date: 2006-04-25; US20060799356P Applic. Date: 2006-05-11

Inventor: GUERET JEAN-LOUIS [FR]; TUGAS CASANOVES MONTSERRAT [FR]


Application No.: US20080031833A1  Published: 07/Feb/2008

Title: Combined energy and topical composition application for regulating the condition of mammalian skin

Applicant/Assignee:

Application No.: 11/712174   Filing Date: 28/Feb/2007

Abstract:Method for regulating the condition of mammalian skin comprising the steps of applying a first personal care composition to an area of skin where regulation is desired, wherein the first personal care composition comprises at least one skin care active selected from the group consisting of niacinamide, salicylic acid, peptides, N-acetyl glucosamine, panthenol, butylated hydroxytoluene, N-acyl amino acid compounds, hexamidine, green tea, ascorbyl glucoside, hexanediol, pentanediol, a skin lightening agent, a heat shock protein potentiator, and mixtures thereof, and delivering energy to the area of skin by contacting the skin with an energy delivery device for a treatment period of at least 2 1/2 minutes, wherein the energy delivery device comprises a skin-contacting surface that is controllably heatable to a temperature of from 37 DEG C. to 50 DEG C.

Priority: US20060781891P Applic. Date: 2006-03-13

Inventor: OBLONG JOHN E [US]; KEMP HELEN R [US]


Application No.: US20080031842A1  Published: 07/Feb/2008

Title: Personal cleansing compositions

Applicant/Assignee:

Application No.: 11/893347   Filing Date: 15/Aug/2007

Abstract:The present invention is a lathering cleansing composition comprising an alkyl ethoxylated polymer, at least one lathering surfactant, an acrylate cross linked copolymer and a particulate material and a lathering surfactant. These compositions provide good lathering and are readily rinsed. The particulate materials enhance cleansing and exfoliation or provide conditioning befits without damage and, or irritation.

Priority: US2004-797981 Applic. Date: 2004-03-11

Inventor: KUHLMAN DENNIS E [US]; KYTE KENNETH E III [US]; COFFINDAFFER TIMOTHY W [US]; MCCLURE MATTHEW D [US]


Application No.: US20080031845A1  Published: 07/Feb/2008

Title: Personal care compositions that deposit hydrophilic benefit agents

Applicant/Assignee:

Application No.: 11/894142   Filing Date: 20/Aug/2007

Abstract:A personal care composition comprising a hydrophilic liquid, a structurant for said hydrophilic liquid, a surface active, a lipid, and an aqueous phase

wherein said lipid, said hydrophilic liquid, said structurant, and said surface active form a lipid phase

wherein said hydrophilic liquid, said structurant, and said surface active are connected to said lipid in said lipid phase. These compositions provide improved skin and/or hair moisturization, appearance, aesthetics and skin and/or hair conditioning during and/or after application, and are useful in providing improved deposition to the desired area of the skin and/or hair. The present invention is further directed to a method of using the personal care composition.

Priority: US2005-103254 Applic. Date: 2005-04-11; US20040564259P Applic. Date: 2004-04-21

Inventor: STELLA QING [US]; PAGE STEVEN H [US]; KACHER MARK L [US]; WEI KARL S [US]; EL-NOKALY MAGDA [US]


Application No.: US20080031907A1  Published: 07/Feb/2008

Title: COSMETIC AND PHARMACEUTICAL FOAM

Applicant/Assignee: FOAMIX LTD

Application No.: 11/770342   Filing Date: 28/Jun/2007

Abstract:The invention relates to uses of an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent as a flame retardant or flame resistant foam. The hydrophobic solvent is preferably mineral oil

medium chain triglycerides

isopropyl myristearate or octyl dodecanol, silicone oil or vegetable oil or mixtures thereof. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, also making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil-soluble pharmaceutical and cosmetic agents.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20020429546P Applic. Date: 2002-11-29

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20080031909A1  Published: 07/Feb/2008

Title: Encapsulated Cosmetic Materials

Applicant/Assignee: DSM IP ASSETS B.V

Application No.: 11/792376   Filing Date: 30/Nov/2005

Abstract:Cosmetic materials, e.g., sunscreen agents are encapsulated by means of a compound of the formula (I) where X is O or NR5

EWG is an electron-withdrawing group

R1, R2, R3, R5 are equal to an H, alykl, cycloalkyl, aryl, or heterocyclic group

or R1, R2 and R5 or R1, R2 and R3 together form a heterocyclic group

and wherein at least one NH or NH2 group, attached to an electron-attracting atom or to an atom that is connected to electron-attracting atom or group such as oxygen, nitrogen and sulphur, is present.

Priority: EP20040029375 Applic. Date: 2004-12-10; WO2005EP12752 Applic. Date: 2005-11-30

Inventor: VAN BENTHEM RUDOLFUS A [NL]; POSCHALKO ALEXANDER [CH]; VOLLHARDT JUERGEN H [CH]


Application No.: US20080031935A1  Published: 07/Feb/2008

Title: Cholinesterase Inhibitors In Liposomes And Their Production And Use

Applicant/Assignee:

Application No.: 11/578191   Filing Date: 21/Apr/2005

Abstract:The invention relates to a pharmaceutical composition based on an active ingredient that is enclosed in liposomes for topical, transdermal application. The interior of said liposomes comprises an acidic, aqueous medium containing at least one cholinesterase inhibitor, preferably from the group containing donepezil, rivastigmine, galantamine, physostigmine, heptylphysostigmine, phenserine, tolserine, cymserine, thiatolserine, thiacymserine, neostigmine, huperzine, tacrine, metrifonate and dichlorvos, or an enantiomer or derivative of at least one of said compounds. In addition, the invention relates to a method for producing said composition, optionally in a sterile form and also to the use of the liposomes charged with the active ingredient in various galenic formulations for topical, transdermal application with a depot effect in the epidermis, for the prophylaxis and/or treatment of cutaneous neuropathic pain or the loss of cutaneous sensory function as a result of neuropathy.

Priority: AT20040000696 Applic. Date: 2004-04-22; WO2005AT00138 Applic. Date: 2005-04-21

Inventor: BODENTEICH ANGELIKA [AT]; BOCKMANN JOSEF [AT]; FRANTSITS WERNER [AT]; PIRICH EBERHARD [AT]; WAGNER ANDREAS [AT]; VORAUER-UHL KAROLA [AT]


Application No.: US20080031967A1  Published: 07/Feb/2008

Title: Compositions, products and methods for controlling weight in a mammal

Applicant/Assignee:

Application No.: 11/973423   Filing Date: 09/Oct/2007

Abstract:Compositions for controlling mammalian weight, said compositions comprising one or more lipolytic agents for stimulating mammalian lipolysis and/or thermogenic agents for modulating mammalian thermogenesis. Products, consumer and otherwise, comprising said compositions and methods of using both the present compositions and products to control mammalian weight.

Priority: US2005-032341 Applic. Date: 2005-01-10

Inventor: BASCOM CHARLES C [US]; YOUNGQUIST ROBERT S [US]; WALANSKI AMY A [US]; HO BEGONIA Y [US]; FUENTES GARY R [US]


Application No.: US20080031979A1  Published: 07/Feb/2008

Title: USE OF EXTRACTS FOR THE TREATMENT OF VIRAL DISORDERS

Applicant/Assignee:

Application No.: 11/462384   Filing Date: 04/Aug/2006

Abstract:The present invention relates to plant extracts and compositions containing such plant extracts useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.

Priority:

Inventor: SALIOU CLAUDE [US]; BODDUPALLI SEKHAR [US]; MAHMOOD KHALID [US]


Application No.: US20080031981A1  Published: 07/Feb/2008

Title: Cosmetic composition containing an extract of Limnocitrus littoralis

Applicant/Assignee: LVMH RECHERCHE

Application No.: 11/805390   Filing Date: 23/May/2007

Abstract:The invention relates to a cosmetic composition, characterized in that it contains, as active agent, an extract of Limnocitrus littoralis obtained by extraction with an extraction solvent selected from the group comprising alcohols and aqueous-alcoholic mixtures, in a cosmetically acceptable vehicle compatible with topical application. It further relates to a method of cosmetic treatment intended especially for soothing non-pathological skin manifestations of inflammatory origin and/or preventing and/or combating the effects of intrinsic and/or photoinduced ageing, comprising the application to the skin of a cosmetic composition of the invention.

Priority: FR20060052784 Applic. Date: 2006-07-04

Inventor: SAUVAN NANCY [FR]; RENIMEL ISABELLE [FR]; LAMY CECILE [FR]; DUPONT DELPHINE [FR]


Application No.: US20080032918A1  Published: 07/Feb/2008

Title: Mast cell-derived renin

Applicant/Assignee: CORNELL RESEARCH FOUNDATION, INC

Application No.: 11/657343   Filing Date: 24/Jan/2007

Abstract:The invention relates to the discovery that renin is present in mast cells and can act in a localized manner to initiate and/or exacerbate a number of conditions. Thus, the invention provides methods for treating cardiac, vascular, lung, liver, cervical, intestinal, muscle, pancreatic, brain, kidney, skin and other conditions that involve inhibiting the synthesis and/or release of renin from mast cells and/or inhibiting the activity of renin after release from mast cells. The methods of the invention can also involve inhibiting elements of the local renin-angiotensin system (e.g. inhibiting ACE and angiotensin II receptors), thereby inhibiting angiotensin II produced locally from mast-cell-derived renin.

Priority: US2004-964567 Applic. Date: 2004-10-13; US20030512142P Applic. Date: 2003-10-17

Inventor: SILVER RANDI B [US]; LEVI ROBERTO [US]


Application No.: US20080032926A1  Published: 07/Feb/2008

Title: Knockout Non-Human Animal

Applicant/Assignee:

Application No.: 11/659807   Filing Date: 09/Aug/2005

Abstract:The present invention relates to a knockout non-human animal whose genome comprises a disruption in at least one allele of the PHF3 gene, useful in developing drugs for diseases with the onset of atopic dermatitis or the like

a totipotent cell such as an ES cell which is essential to production of the above non-human animal

use thereof

and so on.

Priority: JP20040233089 Applic. Date: 2004-08-10; WO2005JP14881 Applic. Date: 2005-08-09

Inventor: NAITO YOSHIKAZU [JP]; OEDA KENJI [JP]; SUKATA TOKUO [JP]; INOUE YOSHIFUMI [JP]


Application No.: US20080032998A1  Published: 07/Feb/2008

Title: Pyrazolopyrimidines, a process for their preparation and their use as medicine

Applicant/Assignee: MERZ PHARMA GMBH & CO. KGAA

Application No.: 11/890230   Filing Date: 03/Aug/2007

Abstract:Substituted pyrazolopyrimidine derivatives of formula (I) wherein R<1 >represents chloro or bromo

R<2>, R<3>, R<4>, R<5>, R<6 >and R<7 >independently represent e.g. hydrogen or C1-6-alkyl

R<8 >represents a radical R<9 >or a radical R<10>, whereby one of the two radicals R<8 >represents R<9 >and the other radical R<8 >represents Ret

R<9 >represents e.g. a phenyl or thiophene group, and R<10 >represents e.g. hydrogen or methyl

are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Priority: US20060835820P Applic. Date: 2006-08-04; US20060877544P Applic. Date: 2006-12-28

Inventor: DANYSZ WOJCIECH [DE]; DEKUNDY ANDRZEJ [DE]; HECHENBERGER MIRKO [DE]; HENRICH MARKUS [DE]; JATZKE CLAUDIA [DE]; NAGEL JENS [DE]; PARSONS CHRISTOPHER G R [DE]; WEIL TANJA [DE]; FOTINS JURIS [LV]; GUTCAITS ALEKSANDRS [LV]; KALVINSH IVARS [LV]; ZEMRIBO RONALDS [LV]; KAUSS VALERJANS [LV]


Application No.: US20080033037A1  Published: 07/Feb/2008

Title: Utilisation de la silymarine et/ou de ses constituants comme agents promoteur de la pigmentation de la peau ou des cheveux

Applicant/Assignee: GREENPHARMA BIOALTERNATIVES

Application No.: 11/818943   Filing Date: 13/Feb/2006

Abstract:The present invention relates to the use of silymarin, or of the main constituents thereof alone or as a mixture, chosen from silybin (or 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine), isosilybin, silydianin, silychristin, silandrin, silymonin and taxifolin, isolated enantiomers thereof and also salts thereof, for the manufacture of compositions for inducing, restoring or stimulating pigmentation of the skin, body hair or head hair. The invention also relates to the use of these agents for the manufacture of compositions for preserving the integrity of the hair, for limiting its loss and for stimulating hair regrowth. Silymarin or the constituents thereof alone or as a mixture are obtained by extraction of a plant of the genus Silybum.

Priority: FR20050001446 Applic. Date: 2005-02-11

Inventor: BERNARD PHILIPPE [FR]; BERNARD FRANCOIS-XAVIER [FR]


Application No.: US20080033038A1  Published: 07/Feb/2008

Title: Compositions of polyphenols and methods of use

Applicant/Assignee:

Application No.: 11/825346   Filing Date: 05/Jul/2007

Abstract:The subject invention concerns materials and methods for treating or preventing any condition or disease that is treatable by a green tea polyphenol, or an analog, isomer, metabolite, or prodrug thereof, wherein the polyphenol is administered as an intranasal formulation to a person or animal in need of treatment. In one embodiment, the intranasal polyphenol formulation comprises (-)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. The subject invention also concerns materials and methods for treating or preventing dementia, such as AIDS-dementia in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof. In one embodiment, a composition of the invention increases expression or activity of a protein that exhibits alpha-secretase activity.

Priority: US20060819527P Applic. Date: 2006-07-07; US20060819248P Applic. Date: 2006-07-07

Inventor: SHYTLE R D [US]; TAN JUN [US]


Application No.: US20080033058A1  Published: 07/Feb/2008

Title: Personal care compositions that deposit hydrophilic benefit agents

Applicant/Assignee:

Application No.: 11/894141   Filing Date: 20/Aug/2007

Abstract:A personal care composition comprising a hydrophilic benefit active, a multi-wetting material, and an aqueous phase, wherein the hydrophilic benefit active may be a hydrophilic solid or a hydrophilic liquid with a structurant, wherein the multi-wetting material and the hydrophilic benefit active form a multi-wetting phase. These compositions provide improved skin and/or hair moisturization, appearance, aesthetics and skin and/or hair conditioning during and/or after application, and are useful in providing improved deposition to the desired area of the skin and/or hair. The present invention is further directed to a method of using the personal care composition.

Priority: US2005-103317 Applic. Date: 2005-04-11; US20040564283P Applic. Date: 2004-04-21

Inventor: STELLA QING [US]; PAGE STEVEN H [US]; KACHER MARK L [US]; WEI KARL S [US]; EL-NOKALY MAGDA [US]


Application No.: US20080033060A1  Published: 07/Feb/2008

Title: Use Of A Compound Modulating At Least One Receiver Selected In A Group Comprising An Interleukin 8 Type B Receptor And Pacap-1 Receptor For Porparing A Pharmaceutical Composition For Rosacea Treatment

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 10/589991   Filing Date: 17/Feb/2005

Abstract:The invention relates to the use of a modulator of at least one receptor chosen from the group comprising the IL-8RB receptor and the PAC-1 receptor for the preparation of a pharmaceutical composition for treating rosacea.

Priority: FR20040001716 Applic. Date: 2004-02-20; WO2005FR00366 Applic. Date: 2005-02-17

Inventor: DOLFI FABRIZIO [FR]; SAFONOVA IRINA [FR]


Application No.: US20080033119A1  Published: 07/Feb/2008

Title: SILOXANE POLYMERS AND USES THEREOF

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 11/830479   Filing Date: 30/Jul/2007

Abstract:A method for preparing a siloxane polymer comprising the steps of (a) providing an aldehyde-based redox initiator

and (b) reacting said redox initiator with a siloxane having a plurality of end-capped hydride moieties to form a siloxane polymer having a plurality of terminal aldehyde moieties.

Priority: US20060835013P Applic. Date: 2006-08-02

Inventor: ASIRVATHAM EDWARD T [US]


Application No.: US20080033334A1  Published: 07/Feb/2008

Title: Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor

Applicant/Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Application No.: 11/888978   Filing Date: 03/Aug/2007

Abstract:Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Priority: US20060835654P Applic. Date: 2006-08-03

Inventor: GURTNER GEOFFREY C [US]; DAUSKARDT REINHOLD H [US]; LONGAKER MICHAEL T [US]; YOCK PAUL [US]


Application No.: US20080038203A1  Published: 14/Feb/2008

Title: Compositions and Methods for Topical Diagnostic and Therapeutic Transport

Applicant/Assignee: REVANCE THERAPEUTICS, INC

Application No.: 10/591486   Filing Date: 03/Mar/2005

Abstract:Compositions and therapeutic methods are provided that are useful agent for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGE The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

Priority: US20040550014P Applic. Date: 2004-03-03; WO2005US06931 Applic. Date: 2005-03-03

Inventor: DAKE MICHAEL D [US]; WAUGH JACOB M [US]


Application No.: US20080038216A1  Published: 14/Feb/2008

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/503570   Filing Date: 11/Aug/2006

Abstract:Personal care composition comprising from about 0.1% to about 15% of an emulsifying silicone elastomer

from about 0.1% to about 40% of at least one solidifying agent

from about 1% to about 75% of an aqueous phase

from about 0.1% to about 74% water

wherein the composition is in the form of a water-in-oil emulsion, has a first hardness of from about 2 g to about 45 g at a first temperature of 21 DEG C., and a second hardness at a second temperature of 33 DEG C., wherein the second hardness is 65% or less of the first hardness.

Priority:

Inventor: ZUKOWSKI JOSEPH MICHAEL [US]; BREYFOGLE LAURIE ELLEN [US]; TANNER PAUL ROBERT [US]; STUMP KARA JOANN [US]; ZHU CHU [US]


Application No.: US20080038228A1  Published: 14/Feb/2008

Title: Method

Applicant/Assignee: DANISCO A/S

Application No.: 10/571992   Filing Date: 24/Sep/2004

Abstract:The present invention relates to the use of a microorganism and/or a metabolite thereof to at least increase the amount of a COX-1 mRNA in a cell. The present invention further relates to the use of a microorganism and/or a metabolite thereof in the manufacture of a medicament to treat the side effects associated with nonsteroidal antiinflammatory drugs (NSAIDs). The present invention further relates to a pharmaceutical preparation comprising in combination a nonsteroidal antiinflammatory drug (NSAIDs) and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The present invention yet further relates to a pharmaceutical preparation comprising in combination betaine or a pharmaceutically acceptable salt thereof and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The microorganism may suitably be a bacterium, preferably from the genus Bifidobacterium.

Priority: GB20030023039 Applic. Date: 2003-10-01; WO2004IB03273 Applic. Date: 2004-09-24

Inventor: RAUTONEN NINA [FI]; NURMI JUSSI [FI]; NURMINEN PAIVI [FI]; PUOLAKKAINEN PAULI [FI]


Application No.: US20080038243A1  Published: 14/Feb/2008

Title: WOUND HEALING COMPOSITIONS AND METHODS USING TROPOELASTIN AND LYSYL OXIDASE

Applicant/Assignee: MATRIX DESIGN

Application No.: 11/838028   Filing Date: 13/Aug/2007

Abstract:The present invention provides compositions and methods for promoting wound healing. The composition comprises virgin monomers of tropoelastin and lysyl oxidase. When the lysyl oxidase comes in contact with the tropoelastin, cross-linking of the tropoelastin monomers will occur to form elastin. Contacting the tropoelastin and lysyl oxidase together and applying the mixture to a wound before substantial cross-linking has occurred promotes wound healing by holding the damaged tissue together, increasing the rate of healing, and decreasing the amount of scarring.

Priority: US2004-973664 Applic. Date: 2004-10-26; US2000-498305 Applic. Date: 2000-02-04

Inventor: ENSLEY BURT D [US]


Application No.: US20080038251A1  Published: 14/Feb/2008

Title: MN/CA IX and MAPK inhibition

Applicant/Assignee:

Application No.: 11/726065   Filing Date: 20/Mar/2007

Abstract:The invention is based upon the discovery that the mitogen-activated protein kinase (MAPK) pathway can increase CA9 expression independently of HIF-1, as well as increasing CA9 expression under HIF-1-dependent pathways initiated by hypoxia or high cell density. Disclosed herein are novel therapeutic methods for treating preneoplastic/neoplastic diseases associated with abnormal MN/CA IX expression, using MAPK pathway inhibitors. Preferably, the MAPK pathway inhibitors are raf kinase inhibitors, particularly the raf kinase inhibitor Sorafenib. Further disclosed are methods for patient therapy selection for MAPK pathway inhibitors, preferably in combination with other cancer therapies, based on detection of abnormal MN/CA9 gene expression in preneoplastic/neoplastic tissues.

Priority: US20060784284P Applic. Date: 2006-03-20

Inventor: PASTOREKOVA SILVIA [SK]; PASTOREK JAROMIR [SK]


Application No.: US20080038264A1  Published: 14/Feb/2008

Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES

Applicant/Assignee: GENENTECH, INC

Application No.: 11/537311   Filing Date: 29/Sep/2006

Abstract:The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US2003-370715 Applic. Date: 2003-02-21; US20020359461P Applic. Date: 2002-02-22

Inventor: BODARY SARAH C [US]; CLARK HILARY [US]; HUNTE BRISDELL [US]; JACKMAN JANET K [US]; SCHOENFELD JILL R [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]; WU THOMAS D [US]


Application No.: US20080038299A1  Published: 14/Feb/2008

Title: Skincare Compositions Comprising Salicylic Acid

Applicant/Assignee: RECKITT & COLMAN (OVERSEAS) LIMITED

Application No.: 10/590061   Filing Date: 19/Feb/2005

Abstract:There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises alicylic acid or a salt thereof and hydrolysed milk protein. The composition is useful in the treatments of acne.

Priority: GB20040003702 Applic. Date: 2004-02-19; GB20040019260 Applic. Date: 2004-08-31; WO2005GB00503 Applic. Date: 2005-02-19

Inventor: STRODTHOLZ IRIS [DE]; SCHMIDT TIMM [DE]; STRAHINJIC IVANA [DE]


Application No.: US20080038300A1  Published: 14/Feb/2008

Title: Self-Adhesive Skin Patch and Combination Set for Cosmetic Skin Care

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/547098   Filing Date: 29/Mar/2006

Abstract:The present invention relates to a skin patch comprising a matrix adhering to the skin and containing at least one active cosmetic substance and a combination with a skin wrapping to generate an effective compression for the treatment of cellulite and/or striae.

Priority: DE200510023149 Applic. Date: 2005-05-13; DE200510053909 Applic. Date: 2005-11-11; WO2006EP61137 Applic. Date: 2006-03-29

Inventor: JASPERS SOEREN [DE]; HARTKOPF CARSTEN [DE]; GAEDE CHRISTIAN [DE]; BODENSCHATZ STEFAN [DE]; POST KATHARINA [NL]; SCHULZ JENS [DE]; WOELLER KARL-HEINZ [DE]


Application No.: US20080038360A1  Published: 14/Feb/2008

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/502866   Filing Date: 11/Aug/2006

Abstract:Personal care composition comprising from about 0.1% to about 15% of an emulsifying silicone elastomer

from about 1% to about 90% of an aqueous phase

and from about 0.001% to about 5% of a coated particulate comprising a core material and a coating material, wherein the coated particulate has a size of from about 5 microns to about 100 microns and comprises from about 1% to about 15%, by weight of the coated particulate, of the coating material, and wherein the coating material comprises polysiloxanes.

Priority:

Inventor: ZUKOWSKI JOSEPH MICHAEL [US]; GRIFFITHS-BROPHY SUSAN ADAIR [US]


Application No.: US20080038374A1  Published: 14/Feb/2008

Title: New Use

Applicant/Assignee: LIPOPEPTIDE AB

Application No.: 11/632553   Filing Date: 26/Jul/2005

Abstract:The present invention relates to the use of a vitamin D compound active in up-regulating the expression and production of hCAP18 in humans for the manufacture of a medicament for treatment of conditions deficient in or benefiting from LL-37. The vitamin D active compound can be used as a medicament for treatment of injured tissues, chronic ulcers, burn wounds, skin infections and atopic dermatitis and for improving the microvasculature. UVB irradiation can also be used to up-regulate hCAP18.

Priority: SE20040001943 Applic. Date: 2004-07-28; WO2005SE01184 Applic. Date: 2005-07-26

Inventor: STAHLE MONA [SE]; WEBER GUNTHER [SE]; HEILBORN JOHAN [SE]


Application No.: US20080038388A1  Published: 14/Feb/2008

Title: Method of Obtaining a Firming Active Principle, Active Principle Thus Obtained and Uses Thereof

Applicant/Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE SILAB

Application No.: 11/661808   Filing Date: 25/Aug/2005

Abstract:The invention relates to a method of obtaining a firming active principle resulting from the solubilisation of Cucurbita pepo seed meal treated by means of enzymatic hydrolysis. The invention also relates to the active principle thus obtained and to the uses thereof in cosmetics.

Priority: FR20040051951 Applic. Date: 2004-09-01; WO2005FR50685 Applic. Date: 2005-08-25

Inventor: PAUFIQUE JEAN [FR]


Application No.: US20080038822A1  Published: 14/Feb/2008

Title: Virus clearance of neoplastic cells from mixed cellular compositions

Applicant/Assignee: ONCOLYTICS BIOTECH INC

Application No.: 11/807921   Filing Date: 30/May/2007

Abstract:The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.

Priority: US2004-931728 Applic. Date: 2004-08-31; US2001-847355 Applic. Date: 2001-05-03; US20010268054P Applic. Date: 2001-02-13; US20010276782P Applic. Date: 2001-03-16; US20000201990P Applic. Date: 2000-05-03; US20000205389P Applic. Date: 2000-05-19

Inventor: MORRIS DONALD [CA]; THOMPSON BRADLEY G [CA]; COFFEY MATTHEW C [CA]


Application No.: US20080039405A1  Published: 14/Feb/2008

Title: Modification of percutaneous absorption of topically active materials

Applicant/Assignee: CRODA, INC

Application No.: 11/788759   Filing Date: 20/Apr/2007

Abstract:The present invention relates to methods of influencing the flux or surface retention time of a topically active pharmaceutical ingredient through skin and formulations relating thereto.

Priority: US20060794602P Applic. Date: 2006-04-25

Inventor: LANGLEY NIGEL A [US]; PEREIRA ABEL G [US]; JOSEPH LAURIE B [US]


Application No.: US20080039458A1  Published: 14/Feb/2008

Title: Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine

Applicant/Assignee: MERZ PHARMA GMBH & CO. KGAA

Application No.: 11/890199   Filing Date: 03/Aug/2007

Abstract:Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y<1>, Y<2>, Y<3>, Y<4 >represent N or C-, whereby at least two of the groups Y<1 >to Y<4 >represent a carbon atom, R<1 >represents chloro or bromo, R<2 >to R<7 >represent e.g. hydrogen, methyl or ethyl

and R<10 >and R<11 >independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Priority: US20060835820P Applic. Date: 2006-08-04; US20060877544P Applic. Date: 2006-12-28

Inventor: DANYSZ WOJCIECH [DE]; DEKUNDY ANDRZEJ [DE]; HECHENBERGER MIRKO [DE]; HENRICH MARKUS [DE]; JATZKE CLAUDIA [DE]; NAGEL JENS [DE]; PARSONS CHRISTOPHER G R [DE]; WEIL TANJA [DE]; FOTINS JURIS [LV]; GUTCAITS ALEKSANDRS [LV]; KALVINSH IVARS [LV]; ZEMRIBO RONALDS [LV]; KAUSS VALERJANS [LV]


Application No.: US20080039476A1  Published: 14/Feb/2008

Title: Pyrazolopyrimidines, a process for their preparation and their use as medicine

Applicant/Assignee: MERZ PHARMA GMBH & CO. KGAA

Application No.: 11/890211   Filing Date: 03/Aug/2007

Abstract:The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y<1>, Y<2 >and Y<3 >independently are e.g. CR<10>, NH, S or O, whereby at least one of Y<1>, Y<2 >and Y<3 >represents CR<10>

R<1 >represents chloro or bromo

R<2>, R<3>, R<4>, R<5>, R<6 >and R<7 >represent e.g. hydrogen or C1-C6-alkyl, and R<10 >represents e.g. hydrogen, halogen or phenyl

which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.

Priority: US20060835820P Applic. Date: 2006-08-04; US20060877544P Applic. Date: 2006-12-28

Inventor: DANYSZ WOJCIECH [DE]; DEKUNDY ANDRZEJ [DE]; HECHENBERGER MIRKO [DE]; HENRICH MARKUS [DE]; JATZKE CLAUDIA [DE]; NAGEL JENS [DE]; GRAHAM RAPHAEL PARSONS CHRISTO [DE]; WEIL TANJA [DE]; FOTINS JURIS [LV]; GUTCAITS ALEKSANDRS [LV]; KALVINSH IVARS [LV]; ZEMRIBO RONALDS [LV]; KAUSS VALERJANS [LV]


Application No.: US20080044365A1  Published: 21/Feb/2008

Title: Concave or annular particles of silicone materials for increasing the sun protection factor of aqueous photoprotective compositions comprising same

Applicant/Assignee: L'OREAL

Application No.: 11/812901   Filing Date: 22/Jun/2007

Abstract:Sunscreen compositions having increased SPF contain at least one aqueous phase, at least one organic UV screening agent and/or at least one inorganic UV screening agent, notably at least one wetting agent, and an effective SPF-increasing amount of concave or annular particles of a silicone material, formulated into a physiologically acceptable medium therefor.

Priority: FR20060052593 Applic. Date: 2006-06-22; US20060819636P Applic. Date: 2006-07-11

Inventor: SIMONNET JEAN-THIERRY [FR]; L ALLORET FLORENCE [FR]


Application No.: US20080044372A1  Published: 21/Feb/2008

Title: Transfer-resistant makeup removing compositions

Applicant/Assignee:

Application No.: 11/894084   Filing Date: 20/Aug/2007

Abstract:The invention relates to a cleansing composition suitable for topical application to human skin, more particularly to an oil-based cleansing composition containing a silicone elastomer gelling agent for removal of make-up from the skin.

Priority: US2001-902048 Applic. Date: 2001-07-10; US20000217120P Applic. Date: 2000-07-10; US20000217872P Applic. Date: 2000-07-12

Inventor: VATTER MICHAEL L [US]


Application No.: US20080044397A1  Published: 21/Feb/2008

Title: COMPOSITIONS TO REDUCE OR PREVENT SKIN CANCER

Applicant/Assignee: ESSENTIAL SKINCARE, LLC

Application No.: 11/465876   Filing Date: 21/Aug/2006

Abstract:Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing therapeutically effective amounts of human alkaline phosphatase, transferrin and alpha1-antitrypsin. In some embodiments, the composition is topically administered and includes all three proteins. Alkaline phosphatase, alone or in combination with transferrin and alpha1-antitrypsin can also be administered by injection with or without simultaneous or sequential topical administration. Administration of compositions topically and/or by injection can be part of a more complex cancer therapy including chemotherapy, radiotherapy, surgery, and electrochemotherapy.

Priority:

Inventor: KISS ZOTAN [US]


Application No.: US20080044444A1  Published: 21/Feb/2008

Title: Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/825406   Filing Date: 05/Jul/2007

Abstract:The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester

a stabilizer selected from the group consisting of at least one surface-active agent

at least one polymeric agent and mixtures thereof

a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US2005-078902 Applic. Date: 2005-03-11; US2007-717897 Applic. Date: 2007-03-13; US2007-653205 Applic. Date: 2007-01-12; US2004-835505 Applic. Date: 2004-04-28; US2004-911367 Applic. Date: 2004-08-04; US20060818634P Applic. Date: 2006-07-05; US20020429546P Applic. Date: 2002-11-29; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BERMAN TAL [IL]; ZIV ENBAL [IL]; SCHUZ DAVID [IL]


Application No.: US20080044494A1  Published: 21/Feb/2008

Title: Skin care compositions containing silicone elastomers

Applicant/Assignee:

Application No.: 11/894085   Filing Date: 20/Aug/2007

Abstract:The present invention relates to a topical skin care composition having improved aesthetics containing a pentapeptide, a tacky solvent, and a dermatologically acceptable delivery system containing the tacky solvent in combination with a silicone elastomer and a carrier for the elastomer. The present invention also relates to methods of using such compositions to regulate the condition of mammalian skin while retaining good aesthetics.

Priority: US2002-132792 Applic. Date: 2002-04-25; US2000-613266 Applic. Date: 2000-07-10

Inventor: ROBINSON LARRY R [US]; HA ROBERT B K [US]; SUNKEL JORGE M [US]; VATTER MICHAEL L [US]


Application No.: US20080044502A1  Published: 21/Feb/2008

Title: USE OF AN AQUEOUS OR HYDROALCOHOLIC EXTRACT OF BAUHINIA FOR THE PREPARATION OF A COMPOSITION

Applicant/Assignee:

Application No.: 11/779344   Filing Date: 18/Jul/2007

Abstract:The present invention relates to a composition comprising an aqueous or hydroalcoholic extract of bauhinia and to the use of an aqueous or hydroalcoholic extract of bauhinia for the preparation of a composition for the care, preservation or improvement of the general state of the skin or hair, for the prophylaxis or prevention of human skin or human hair ageing processes and for the prophylaxis and/or treatment of diseases associated with skin ageing.

Priority: DE20031029955 Applic. Date: 2003-07-03; US2004-876632 Applic. Date: 2004-06-28

Inventor: WIRTH CORINNA [DE]; BUCHHOLZ HERWIG [DE]


Application No.: US20080045467A1  Published: 21/Feb/2008

Title: Composition Containing Ginsenoside F1 Or Compound K For Skin External Application

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 10/586973   Filing Date: 01/Jun/2004

Abstract:The present invention relates to an inhibitor for the biosynthesis of gelatinase comprising ginsenoside F1 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) or compound K (20-0-beta-D-glucopyranosyl-20(S)-protopanaxadiol), which is a chief metabolite of ginseng saponin, as an active ingredient

and a cosmetic/medical composition for the prevention of skin-aging comprising the same which is superior in inhibiting the decomposition of epidermal-dermal junction and also in accelerating the generation thereof.

Priority: KR20040004714 Applic. Date: 2004-01-26; WO2004KR01305 Applic. Date: 2004-06-01

Inventor: KIM SU-NAM [KR]; KANG BYUNG YOUNG [KR]; KIM SU-JONG [KR]; LEE SO-HEE [KR]; CHOI GYU-HO [KR]; LEE BYEONG-GON [KR]; KIM HAN-KON [KR]


Application No.: US20080045479A1  Published: 21/Feb/2008

Title: Compositions and methods for regulating mammalian keratinous tissue

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/891860   Filing Date: 14/Aug/2007

Abstract:Skin care compositions and methods for regulating the condition of mammalian keratinous tissue containing an effective amount of a dipalmitoyl hydroxyproline salt and a second skin care compound selected from hexamidine compounds, sugar amine compounds and their combination.

Priority: US2003-418594 Applic. Date: 2003-04-17

Inventor: ROBINSON LARRY R [US]; TANNER PAUL R [US]


Application No.: US20080045594A1  Published: 21/Feb/2008

Title: Use of at Least One Conjugated Triene-Containing Fatty Acid for Preparing a Medicine for Treating Inflammation

Applicant/Assignee: LABORATOIRES EXPANSCIENCE

Application No.: 11/572769   Filing Date: 20/Jul/2005

Abstract:The invention concerns the use of at least one conjugated triene-containing fatty acid for preparing a medicine for treating inflammation selected among the group consisting of alpha-eleostearic acid, catalpic acid, calendic acid, jacaric acid, licanic acid and beta-eleostearic acid for making a medicine for treating inflamatory diseases and/or metabolic disorders following an inflammation. The inflammatory diseases and/or metabolic disorders following an inflammation may be skin cancers, sun burn, benign summer light eruption, allergic and/or irritative reactions, gingivitis and periodontitis, vulvitis and vaginitis or arthritis and arthrosis. The medicine also enables healing to be promoted. Said fatty acid conjugates can also be used in the cosmetic treatment of cellulitis.

Priority: FR20040008230 Applic. Date: 2004-07-26; WO2005FR01859 Applic. Date: 2005-07-20

Inventor: PICCIRILLI ANTOINE [FR]; PICCARDI NATHALIE [FR]; MISKA PHILIPPE [FR]


Application No.: US20080045880A1  Published: 21/Feb/2008

Title: Device and method for single-needle in vivo electroporation

Applicant/Assignee:

Application No.: 11/804703   Filing Date: 18/May/2007

Abstract:Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue

Priority: US2007-704591 Applic. Date: 2007-02-09; US20060772255P Applic. Date: 2006-02-11

Inventor: KJEKEN RUNE [US]; MATHIESEN IACOB [US]; TJELLE ELISABETH T [US]; MCHUGH GEORGE [US]


Application No.: US20080048453A1  Published: 28/Feb/2008

Title: Tethered Wind Turbine

Applicant/Assignee:

Application No.: 11/830769   Filing Date: 30/Jul/2007

Abstract:The tethered wind turbine uses an aerodynamic, flow-concentrating shape and lighter-than-air construction utilizing a lifting gas and an electrically conductive tether fixed to ground to reap energy from the wind at low or high altitude. The design has no need for the large, expensive, bulky and unsightly tower structures, pivoting nacelles, or gearboxes presently used in conventional horizontal axis windmills. The tethered wind turbine of this invention easily and passively floats aloft downwind to a direction and position that is aligned with the wind. The invention uses sensors and control modules to fly gracefully at an optimal altitude in most wind regimes and also to ascend/descend when appropriate to seek shelter from extreme weather conditions. Ideally, the tethered wind turbine of this invention would utilize carbon nanotube materials in its tether for both structural and conductive purposes. The ring-wing section profile in the preferred embodiment of this invention optimally would have a very low coefficient of drag. A major benefit of this invention is potentially much lower cost per installed kilowatt capacity and a lower operating cost per kilowatt hour delivered to the end user.

Priority: US20060834518P Applic. Date: 2006-07-31

Inventor: AMICK DOUGLAS J [US]


Application No.: US20080050317A1  Published: 28/Feb/2008

Title: Oleaginous pharmaceutical and cosmetic foam

Applicant/Assignee: FOAMIX LTD

Application No.: 11/894668   Filing Date: 20/Aug/2007

Abstract:The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition

at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition

a therapeutically effective amount of at least one active agent

and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2004-835505 Applic. Date: 2004-04-28; US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]


Application No.: US20080050318A1  Published: 28/Feb/2008

Title: Use of a combination of components with an inhibitory synergistic effect on calcium channels to prevent or treat wrinkles and fine lines

Applicant/Assignee: L'OREAL S.A

Application No.: 11/434266   Filing Date: 16/May/2006

Abstract:Disclosed herein is a composition for topical application to skin, comprising, in a physiologically acceptable medium (i) at least one peptide comprising at least one amino acid sequence derived from the amino acid sequence of the protein SNAP 25, and (ii) at least one calcium-channel inhibitor. Further disclosed is the use of this combination in a composition suitable for topical application to the skin, as an agent for preventing or treating wrinkles and fine lines, such as expression wrinkles, as well as a cosmetic treatment process comprising applying to the skin the composition.

Priority: FR20020014183 Applic. Date: 2002-11-13; US2003-705857 Applic. Date: 2003-11-13; US20020427575P Applic. Date: 2002-11-20

Inventor: RENAULT BEATRICE [FR]


Application No.: US20080050332A1  Published: 28/Feb/2008

Title: Method of skin care and/or treatment using glutaredoxin

Applicant/Assignee:

Application No.: 11/510166   Filing Date: 25/Aug/2006

Abstract:Methods for the prevention and treatment of skin damage arising from the exposure to UV radiation, air pollution and other stressors capable of leading to the formation of free radicals, using the small-dithiol protein glutaredoxin in a dermatologically acceptable carrier that can be applied topically are disclosed. Some embodiments may include other proteins such as superoxide dismutase and/or catalase, as well as other antioxidant molecules such as reduced glutathione, vitamin E, vitamin C, lycopene, astaxanthin and/or tocotrienols.

Priority:

Inventor: SIVAK HANNAH NAOMI [US]


Application No.: US20080050398A1  Published: 28/Feb/2008

Title: Composition Comprising Beta-Defensin 2

Applicant/Assignee:

Application No.: 11/864386   Filing Date: 28/Sep/2007

Abstract:The invention relates to compositions comprising at least one peptide with a structure or structural pattern of beta-defensin 2 and/or its derivatives, especially human beta-defensin 2. The compositions are selected in particular from cosmetic and/or pharmaceutical compositions, cleaning and/or washing agents, water-treatment agents and cooling lubricants. The invention also relates to the use of peptides with a structure or structural pattern of beta-defensin 2 and/or its derivatives, especially human beta-defensin 2, as an antimicrobial active ingredient in the aforementioned agents.

Priority: DE200510014687 Applic. Date: 2005-03-29; WO2006EP02760 Applic. Date: 2006-03-25

Inventor: BOCKMUEHL DIRK [DE]; HOEHNE HEIDE-MARIE [DE]


Application No.: US20080050409A1  Published: 28/Feb/2008

Title: Water based clear sunscreen and insect repellent composition

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/510304   Filing Date: 25/Aug/2006

Abstract:A clear, water based, homogeneous insect repellent sunscreen composition, comprising an oil soluble hydrophobic sunscreen component, an amido insect repellent component, an alcohol component, and water.

Priority:

Inventor: PECHKO ANDREW H [US]; POLYWODA VINCENT T [US]


Application No.: US20080050424A1  Published: 28/Feb/2008

Title: TRANSDERMAL THERAPEUTIC SYSTEM FOR TREATING PARKINSONISM

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG SCHWARZ PHARMA LIMITED

Application No.: 11/931666   Filing Date: 31/Oct/2007

Abstract:A transdermal therapeutic system (TTS) comprises a silicone-based polymer adhesive system having distributed therein (-)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol free base in an amount of about 5% to 40% by weight. The adhesive system comprises a silicone adhesive and an additive having increased solubility for the active substance, in an amount effective to increase dissolving capacity of the matrix for the active substance.

Priority: DE19981014084 Applic. Date: 1998-03-30; US2004-936620 Applic. Date: 2004-09-07; US2000-647290 Applic. Date: 2000-11-28; WO1999EP01795 Applic. Date: 1999-03-18

Inventor: MULLER WALTER [DE]; PECK JAMES V [US]


Application No.: US20080050434A1  Published: 28/Feb/2008

Title: Novel Composition for Topical Delivery

Applicant/Assignee:

Application No.: 10/593136   Filing Date: 17/Mar/2005

Abstract:Pharmaceutical composition for topical administration comprising of at least one active ingredient, its salts, esters, hydrates or derivatives

a gelator system consisting of a fiend of surfactants, a solvent system comprising at least one oily component

an aqueous phase

optionally containing one or more stabilizing agent

and other pharmaceutically acceptable excipients

and process for preparing such compositions are provided. Also provided is a method for the management/treatment of fungal, bacterial or microbial infections, inflammations, autoimmune conditions, or hormonal disorders which comprises administering a pharmaceutically effective amount of such pharmaceutical composition to a subject in need of such treatment. The compositions of the present invention are non-greasy and easily water washable, and provides an enhanced localization of hydrophobic and/or amphiphilic active ingredients on the skin.

Priority: IN2004DE00501 Applic. Date: 2004-03-18; WO2005IN00086 Applic. Date: 2005-03-17

Inventor: JAIN RAJESH [IN]; CHAND KOUR [IN]; SINGH SUKHJEET [IN]; SIHORKAR VAIBHAV [IN]


Application No.: US20080051312A1  Published: 28/Feb/2008

Title: FOAMABLE COMPOSITIONS CONTAINING ALCOHOL

Applicant/Assignee: THE CLOROX COMPANY

Application No.: 11/466657   Filing Date: 23/Aug/2006

Abstract:This invention relates to compositions containing lower (C1-C4) alcohol and a polymeric fluorosurfactant formulated for being dispensed as a foam product. More particularly, the invention relates to improved compositions formulated with polymeric fluorosurfactants with pendant perfluoroalkyl side chains of a fully fluorinated chain length of C1-C7. The compositions also relate to use for personal care, such as skin sanitizing and cleansing.

Priority:

Inventor: LESTAGE DAVID [US]; SCHEUING DAVID R [US]; CUMBERLAND SCOTT L [US]; TEMPLIN GRANT [US]


Application No.: US20080051408A1  Published: 28/Feb/2008

Title: Use of a Pde 5 Inhibitor for Treating and Preventing Hypopigmentary Disorders

Applicant/Assignee:

Application No.: 11/660351   Filing Date: 15/Jul/2005

Abstract:The invention relates to the use of PDE5 inhibitors, preferably sildenafil or tadalafil, optionally in combination with a further active ingredient, for treating and/or preventing hypopigmentary disorders.

Priority: EP20040019695 Applic. Date: 2004-08-19; US20040603069P Applic. Date: 2004-08-19; WO2005EP07747 Applic. Date: 2005-07-15

Inventor: PEUKER HEIDEMARIE [DE]


Application No.: US20080051463A1  Published: 28/Feb/2008

Title: ANTHRACENE COMPOUNDS AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOR DISORDERS

Applicant/Assignee: AETERNA ZENTARIS GMBH

Application No.: 11/833254   Filing Date: 03/Aug/2007

Abstract:The present invention provides novel anthracene compounds according to the formulae (I) and (II) and also selected anthracene compound compounds. The present invention furthermore provides a process for preparing such anthracene compounds. Also provided are pharmaceutical formulations comprising these anthracene compounds. The anthracene compounds provided are particularly suitable for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions which can be treated by inhibiting tubulin polymerization and/or by inhibiting microtubuli-based motor proteins, in particular various tumor disorders.

Priority: EP20060016401 Applic. Date: 2006-08-07; US20070894935P Applic. Date: 2007-03-15; US20060835431P Applic. Date: 2006-08-04

Inventor: GERLACH MATTHIAS [DE]; GUNTHER ECKHARD [DE]; SCHMIDT PETER [DE]; PRINZ HELGE [DE]; BOHM KONRAD [DE]; UNGER EBERHARD [DE]


Application No.: US20080051490A1  Published: 28/Feb/2008

Title: Medical Devices and Applications of Polyhydroxyalkanoate Polymers

Applicant/Assignee:

Application No.: 11/836615   Filing Date: 09/Aug/2007

Abstract:Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Priority: US2007-623593 Applic. Date: 2007-01-16; US2004-020896 Applic. Date: 2004-12-22; US2002-136499 Applic. Date: 2002-05-01; US2000-535146 Applic. Date: 2000-03-24; US19990142238P Applic. Date: 1999-07-02; US19990126180P Applic. Date: 1999-03-25

Inventor: WILLIAMS SIMON F [US]; MARTIN DAVID P [US]; SKRALY FRANK A [US]


Application No.: US20080051692A1  Published: 28/Feb/2008

Title: APPLICATOR CARTRIDGE FOR AN ELECTROKINETIC DELIVERY SYSTEM FOR SELF ADMINISTRATION OF MEDICAMENTS

Applicant/Assignee: TRANSPORT PHARMACEUTICALS, INC

Application No.: 11/565335   Filing Date: 30/Nov/2006

Abstract:An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.

Priority: US20050740678P Applic. Date: 2005-11-30; US20060743528P Applic. Date: 2006-03-17; US20060743746P Applic. Date: 2006-03-24

Inventor: PETERSEN JOHN S [US]; GOLDBERG DENNIS I [US]; KELLAND JAMES W [US]; EHTEREDGE ROBERT W [US]; BARSNESS MICHAEL S [US]; CHANG KUOWEI [US]


Application No.: US20080051695A1  Published: 28/Feb/2008

Title: HIGH-ASPECT-RATIO MICRODEVICES AND METHODS FOR TRANSDERMAL DELIVERY AND SAMPLING OF ACTIVE SUBSTANCES

Applicant/Assignee:

Application No.: 11/932593   Filing Date: 31/Oct/2007

Abstract:High-aspect-ratio microdevices comprising microneedles, microknives and microblades and their manufacturing methods are disclosed. These devices can be used for the delivery of therapeutic agents across the skin or other tissue barriers to allow chemical and biological molecules getting into the circulation systems. The microneedles can also be used to withdraw body fluids for analysis of clinically relevant species when the device has an integrated body fluid sensor or sensor array in the vicinity of microneedles.

Priority: US2005-908584 Applic. Date: 2005-05-18

Inventor: XU BAI [US]


Application No.: US20080057011A1  Published: 06/Mar/2008

Title: Composition structured with a polymer containing a heteroatom and an Organogelator

Applicant/Assignee: L'OREAL S.A.,

Application No.: 11/826997   Filing Date: 19/Jul/2007

Abstract:A physiologically acceptable composition, in particular a cosmetic composition, comprising at least one liquid fatty phase which comprises (i) at least one structuring polymer having a polymer skeleton which comprises at least one hydrocarbon-based repeating unit comprising at least one hetero atom

and (ii) at least one organogelator.

Priority: US2002-129377 Applic. Date: 2002-10-16; WO2001IB02780 Applic. Date: 2001-12-12

Inventor: FERRARI VERONIQUE [FR]


Application No.: US20080057090A1  Published: 06/Mar/2008

Title: Wrinkle masking film composition for skin

Applicant/Assignee:

Application No.: 11/515150   Filing Date: 01/Sep/2006

Abstract:A film product composition that has a refractive index that matches the refractive index of the skin. The composition is made from polymers, polymers plus additives, including plasticizers, which have an average effective or actual refractive index of from 1.4 to 1.6. The refractive index of the composition matches the skin's refractive index, and therefore is helpful at masking skin fissures and imperfections such as wrinkles, cracks, abrasions and the like.

Priority:

Inventor: MCENTIRE EDWARD ENNS [US]; STOCKL REBECCA REID [US]; MUNJAL RAMESH CHAND [US]; CHRISTIAN VICKY LYNN [US]


Application No.: US20080057091A1  Published: 06/Mar/2008

Title: COMPOSITIONS WITH SEVERAL HYALURONIC ACID FRACTIONS FOR COSMETIC USE

Applicant/Assignee: NOVOZYMES BIOPOLYMER A/S

Application No.: 11/773736   Filing Date: 05/Jul/2007

Abstract:The present invention provides a moisturizing, cosmetic, or anti-wrinkle product comprising at least two hyaluronic acid fractions, or salts thereof, wherein a fraction has an average molecular weight in the range of 8,000-100,000 Da, and a fraction has an average molecular weight in the range of 500,000-1,100,000 Da.

Priority: DK20060000938 Applic. Date: 2006-07-07; US20060819684P Applic. Date: 2006-07-10

Inventor: ABDELLAOUI KHADIJA S [DK]; MALLE BIRGITTE M [DK]


Application No.: US20080058285A1  Published: 06/Mar/2008

Title: Colored perfumed compositions comprising at least one alkyl-beta,beta'-diphenylacrylate or alkyl alpha-cyano-beta,beta'-diphenylacrylate compound and at least one soluble organic UV-A filter

Applicant/Assignee: L'OREAL, PARIS, FRANCE

Application No.: 11/892942   Filing Date: 28/Aug/2007

Abstract:Topically applicable colored and perfumed compositions, well suited for perfuming such human keratinous substrates as the skin, lips and/or integuments, contain, formulated into a cosmetically acceptable medium: a) at least 1% by weight of a perfuming substance

b) at least one volatile alcohol and/or volatile silicone oil

c) at least one coloring agent which is soluble in said medium

d) at least 0.2% by weight of at least one alkyl beta,beta'-diphenylacrylate or alkyl alpha-cyano-beta,beta'-diphenylacrylate compound

and a) at least one organic UV-A filter which is soluble in said medium

b) and, optionally, water.

Priority: FR20060007619 Applic. Date: 2006-08-30; US20070899628P Applic. Date: 2007-02-06

Inventor: PICARD-LESBOUEYRIES ELISABETH [FR]; DESGRANGES LILIANE L [FR]


Application No.: US20080058412A1  Published: 06/Mar/2008

Title: 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same

Applicant/Assignee: GENFIT

Application No.: 10/585329   Filing Date: 07/Jan/2005

Abstract:The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for preparing said derivatives.

Priority: FR20040000123 Applic. Date: 2004-01-08; FR20040009257 Applic. Date: 2004-09-01; WO2005FR00040 Applic. Date: 2005-01-07

Inventor: CAUMONT-BERTRAND KARINE [FR]; DELHOMEL JEAN-FRANCOIS [FR]


Application No.: US20080063607A1  Published: 13/Mar/2008

Title: Oleaginous pharmaceutical and cosmetic foam

Applicant/Assignee: FOAMIX LTD

Application No.: 11/894798   Filing Date: 20/Aug/2007

Abstract:The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.

Priority: US2007-653205 Applic. Date: 2007-01-12; US2004-911367 Applic. Date: 2004-08-04; US2006-430599 Applic. Date: 2006-05-09; US2004-835505 Applic. Date: 2004-04-28; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]; DANZIGER JORGE [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]


Application No.: US20080063677A1  Published: 13/Mar/2008

Title: THERAPEUTIC, NUTRACEUTICAL AND COSMETIC APPLICATIONS FOR EGGSHELL MEMBRANE AND PROCESSED EGGSHELL MEMBRANE PREPARATIONS

Applicant/Assignee: NEW LIFE RESOURCES, LLC

Application No.: 11/943169   Filing Date: 20/Nov/2007

Abstract:The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membranes processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.

Priority: US2004-797747 Applic. Date: 2004-03-10

Inventor: LONG FRANK D [US]; ADAMS RANDALL G [US]; DEVORE DALE P [US]; FRANKLIN MARSHALL R [US]


Application No.: US20080063698A1  Published: 13/Mar/2008

Title: Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use

Applicant/Assignee: NOVEN PHARMACEUTICALS, INC

Application No.: 11/897189   Filing Date: 29/Aug/2007

Abstract:The invention relates to compositions and methods for making a transdermal drug delivery system capable of achieving substantially zero-order kinetics for delivery of the active agent over a period of time in excess of 24 hours and at least 72 hours, comprising a pharmaceutically acceptable active agent carrier and a rosin ester which provides a crystal inhibiting and drug stabilizing effect on the active agents incorporated therein.

Priority: US2004-751152 Applic. Date: 2004-01-02; US2003-353624 Applic. Date: 2003-01-29; US2001-010342 Applic. Date: 2001-12-05; US20000251294P Applic. Date: 2000-12-05

Inventor: HARTWIG ROD L [US]


Application No.: US20080063736A1  Published: 13/Mar/2008

Title: Composition Having Effect Of Moxibustion And Press Pellet Using The Same

Applicant/Assignee:

Application No.: 11/628275   Filing Date: 28/Nov/2005

Abstract:Disclosed herein is a composition with moxibustion effects comprising 20-40% by weight of an artemisia extract, 0-20% by weight of an auxiliary herbal material, 0-20% by weight of a resin and 30-60% by weight of a far-infrared radiating powder. Further disclosed is a method for preparing the composition, a press pellet for skin stimulation using the composition, and patch and sheet formulations comprising the composition. When the press pellet using the composition is attached to the affected parts or acupoints in a simple manner, acupuncture, moxibustion, far-infrared radiation and anion emission effects can be simultaneously attained.

Priority: KR20040033932U Applic. Date: 2004-11-30; KR20050068646 Applic. Date: 2005-07-27; WO2005KR04022 Applic. Date: 2005-11-28

Inventor: KIM JIN SUB [KR]


Application No.: US20080064034A1  Published: 13/Mar/2008

Title: Multi-Cellular Test Systems

Applicant/Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWAND

Application No.: 11/597167   Filing Date: 02/Mar/2005

Abstract:The invention relates to methods for testing substances using multicellular in vitro test systems, in particular systems that resemble organs, and to devices and kits for carrying out said methods.

Priority: DE200410025080 Applic. Date: 2004-05-21; WO2005EP02197 Applic. Date: 2005-03-02

Inventor: KRUSE CHARLI [DE]; FUHR GUENTER [DE]


Application No.: US20080064641A1  Published: 13/Mar/2008

Title: Novel Peptide and Pharmaceutical Composition Containing Said Peptide

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS LABORATOIRES D'ANJOU CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Application No.: 11/572774   Filing Date: 29/Jul/2005

Abstract:The invention relates to a novel peptide, a pharmaceutical composition containing said peptide and to the use of said composition for treating various skin alternations. More particularly, the treatment of said alterations consists in reinforcing the derma-epidermal junction and the cell-matrix and/or cell-cell adherence of epidermis and in promoting the repair of a cutaneous surface.

Priority: FR20040008383 Applic. Date: 2004-07-29; WO2005FR01999 Applic. Date: 2005-07-29

Inventor: ROUSSELLE PATRICIA [FR]


Application No.: US20080064668A1  Published: 13/Mar/2008

Title: 1,3-Diacylated, 26,27-Alkyl/Haloakyl Vitamin D3 Compounds and Methods of Use Thereof

Applicant/Assignee: BIOXELL S.P.A

Application No.: 10/572995   Filing Date: 24/Sep/2004

Abstract:The invention provides (1,3)di-acylated vitamin D3 analogs of cholecalciferol, substituted at carbon (20) with methyl or cyclopropyl wherein carbon (16) is a single or double bond, and carbon (23) is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon (25). The invention provides pharmaceutically acceptable esters, salts, and pro-drugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and pharmaceutical compositions containing the compounds are also disclosed.

Priority: GB20030022395 Applic. Date: 2003-09-24; GB20040004567 Applic. Date: 2004-03-01; US20030505735P Applic. Date: 2003-09-24; WO2004US31412 Applic. Date: 2004-09-24

Inventor: USKOKOVIC MILAN R [US]; ADORINI LUCIANO [IT]; PENNA GIUSEPPE [IT]; COLLI ENRICO [IT]


Application No.: US20080064687A1  Published: 13/Mar/2008

Title: Novel thiourea derivatives and the pharmaceutical compositions containing the same

Applicant/Assignee:

Application No.: 11/727413   Filing Date: 26/Mar/2007

Abstract:The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Priority: KR20000048385 Applic. Date: 2000-08-21; KR20000048388 Applic. Date: 2000-08-21; KR20000085126 Applic. Date: 2000-12-29; US2002-169805 Applic. Date: 2002-07-09; WO2001KR01407 Applic. Date: 2001-08-20

Inventor: SUH YOUNG G [KR]; OH UH T [KR]; KIM HEE D [KR]; LEE JEE W [KR]; PARK HYEUNG G [KR]; PARK OK H [KR]; LEE YONG S [KR]; PARK YOUNG H [KR]; JOO YUNG H [KR]; CHOI JIN K [KR]; LIM KYUNG M [KR]; KIM SUN Y [KR]; KIM JIN K [KR]; KOH HYUN J [KR]; MOH JOO H [KR]; JEONG YEON S [KR]; YI JUNG B [KR]; OH YOUNG I [KR]


Application No.: US20080064714A1  Published: 13/Mar/2008

Title: Novel Pyrrolodihydroisoquinolines

Applicant/Assignee: NYCOMED GMBH

Application No.: 11/794494   Filing Date: 11/Jan/2006

Abstract:The invention relates to novel pyrrolodihydroisoquinoline derivatives which are efficacious inhibitors of cellular (hyper)proliferation and/or inducers of apoptosis in cancer cells.

Priority: EP20050100155 Applic. Date: 2005-01-12; WO2006EP50165 Applic. Date: 2006-01-11

Inventor: VENNEMANN MATTHIAS [DE]; BAR THOMAS [DE]; BRAUNGER JUERGEN [DE]; GEKELER VOLKER [DE]; GIMMNICH PETRA [DE]; CIAPETTI PAOLA [FR]; CONTRERAS JEAN-MARIE [FR]; WERMUTH CAMILLE G [FR]


Application No.: US20080064720A1  Published: 13/Mar/2008

Title: 2,6-Quinolinyl And 2,6-Naphthyl Derivatives, Processes For Preparing Them And Their Uses As Vla-4 Inhibitors

Applicant/Assignee: UCB, S.A UCB PHARMA S.A

Application No.: 10/513347   Filing Date: 15/Apr/2003

Abstract:The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent inflammatory diseases such as for example asthma, allergic rhinitis, sinusitis, conjunctivitis, food allergy, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and atherosclerosis. Formula (I): wherein X is N or CH.

Priority: EP20020009746 Applic. Date: 2002-04-30; WO2003EP03909 Applic. Date: 2003-04-15

Inventor: LASSOIE MARIE-AGNES [BE]; KNERR LAURENT [FR]; DEMAUDE THEIRRY [BE]; DE LAVELEYE-DEFAIS FRANCOISE [FR]; KOGEJ THIERRY [BE]; QUERE LUC [BE]; ROUTIER SYLVAIN [FR]; GUILLAUMET GERALD [FR]


Application No.: US20080064755A1  Published: 13/Mar/2008

Title: Topical application of adapalene for the long-term treatment of acne vulgaris

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 11/878736   Filing Date: 26/Jul/2007

Abstract:Administration of adapalene in a topical medicament to a patient so as to sustain its biological response in the treatment of acne vulgaris, wherein the administration pattern of the topical medicament comprises topically applying onto the afflicted skin area a therapeutically effective amount of adapalene at least once every two days for at least 6 months.

Priority: WO2006EP01140 Applic. Date: 2006-01-23; US20050647306P Applic. Date: 2005-01-26

Inventor: GRAEBER MICHAEL [US]


Application No.: US20080069779A1  Published: 20/Mar/2008

Title: Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/900072   Filing Date: 10/Sep/2007

Abstract:Vitamin and flavonoid containing compositions are provided that are stable to degradation. Stabilized compositions include one or more features including a hygroscopic solvent at a sufficient concentration to provide an Aw value of the hygroscopic vitamin and or flavonoid containing composition of less than 0.9, antioxidant flavonoids that are preferentially oxidized before the vitamin, preservatives, and hydrocarbon propellants selected to reduce the oxidation potential of the composition.

Priority: US2006-430599 Applic. Date: 2006-05-09; US2004-835505 Applic. Date: 2004-04-28; US20060843140P Applic. Date: 2006-09-08; US20060784793P Applic. Date: 2006-03-21; US20050679020P Applic. Date: 2005-05-09; US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BERMAN TAL [IL]; SCHUZ DAVID [IL]


Application No.: US20080069784A1  Published: 20/Mar/2008

Title: Regulation of mammalian keratinous tissue using skin and/or hair care actives

Applicant/Assignee:

Application No.: 11/820386   Filing Date: 19/Jun/2007

Abstract:Personal care compositions containing an active selected from the group consisting of Lauryl p-Cresol Ketoxime, Bis-abolol and ginger extract, 4-(1-Phenylethyl)1,3-benzenediol, Lupin (Lupinus albus) oil & wheat (Triticum vulgare) germ oil unsaponifiables, Hydrolyzed lupin protein, Extract of L-lysine and L-arginine peptides, Oil soluble vitamin C, Evodia rutaecarpa fruit extract, Zinc pidolate and zinc PCA, Unsaponifiable fraction of olive (olea Europaea) oil, Alpha-linoleic acid, p-thymol, and combinations thereof are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US20060818152P Applic. Date: 2006-06-30

Inventor: MILLIKIN CHERI L [US]; BISSETT DONALD L [US]; CLEAR ROSE M [US]


Application No.: US20080069787A1  Published: 20/Mar/2008

Title: ACIDIC COMPOSITION FOR EXTERNAL USE, AND AGENT FOR ACCELERATING PENETRATION INTO SKIN OR THE LIKE OF COSMETIC PREPARATION, HAIR-GROWING AGENT AND PREPARATION FOR EXTERNAL USE EACH CONTAINING THE COMPOSITION

Applicant/Assignee:

Application No.: 11/851939   Filing Date: 07/Sep/2007

Abstract:An acidic composition for external use which contains an acidic poly saccharide and water as essential ingredients, and an agent for accelerating the penetration into skin or the like of a cosmetic preparation, hair-growing agent or preparation for external use, each containing the composition. The composition is easy to manufacture, and shows a stronger cosmetic or therapeutic effects than conventional compositions.

Priority: JP20010326552 Applic. Date: 2001-10-24; JP20010166901 Applic. Date: 2001-06-01; US2003-479210 Applic. Date: 2003-12-01

Inventor: TANAKA MASAYA [JP]


Application No.: US20080069808A1  Published: 20/Mar/2008

Title: Ec Sod and Cell Transducing Ec Sod and Use Thereof

Applicant/Assignee: BIO CLUE & SOLUTION CO., LTD

Application No.: 10/577775   Filing Date: 29/Oct/2004

Abstract:The present invention relates to an EC SOD, a cell-transducing EC SOLD, and the use thereof. More particularly, the present invention relates to an EC SOD, an EC SOD fusion protein enhanced Cell-transduction ability, and the use thereof for preventing or treating skin diseases.

Priority: KR20030076629 Applic. Date: 2003-10-31; WO2004KR02757 Applic. Date: 2004-10-29

Inventor: KIM TAE-YOON [KR]; CHOUNG BO-YEUN [KR]


Application No.: US20080069837A1  Published: 20/Mar/2008

Title: Composition and method for treating cancer using herpes virus

Applicant/Assignee:

Application No.: 11/827108   Filing Date: 09/Jul/2007

Abstract:The present invention provides a herpes virus in which a non-essential gene for replication is inactivated. More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.

Priority: JP20010300931 Applic. Date: 2001-09-28; JP20010139094 Applic. Date: 2001-05-09; WO2002JP04547 Applic. Date: 2002-05-09; US2003-477444 Applic. Date: 2003-11-07

Inventor: NISHIYAMA YUKIHIRO [JP]


Application No.: US20080069841A1  Published: 20/Mar/2008

Title: Pharmaceutical Compositions Containing Botulinum Neurotoxin A2

Applicant/Assignee:

Application No.: 11/659448   Filing Date: 03/Aug/2005

Abstract:A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics select from the group consisting of

(a) a much longer duration of action

(b) a much faster rate of onset of muscular paralysis

(c) a significantly greater intramuscular safety margin

(d) a selective action on inhibition of skeletal muscle contraction

(e) a selective action on inhibition of pain-related (nociceptive) nerve cell function: Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.

Priority: GB20040017367 Applic. Date: 2004-08-04; GB20040021290 Applic. Date: 2004-09-24; GB20040021288 Applic. Date: 2004-09-24; GB20040023952 Applic. Date: 2004-10-28; GB20040023953 Applic. Date: 2004-10-28; WO2005GB03036 Applic. Date: 2005-08-03

Inventor: PANJWANI NAVEED [GB]; WEBB PAUL [GB]; PICKETT ANDY [GB]


Application No.: US20080069876A1  Published: 20/Mar/2008

Title: Method for preparing solid dosage forms that form a paste, cream or gel when diluted for final use

Applicant/Assignee:

Application No.: 11/901120   Filing Date: 14/Sep/2007

Abstract:Solid compositions capable of forming a paste, cream or gel suitable for use as a personal hygiene product when diluted with a liquid are disclosed. Methods of making and using solid compositions capable of forming a paste, cream or gel suitable for use as a personal hygiene product when diluted with a liquid are also disclosed.

Priority: US20060825698P Applic. Date: 2006-09-14

Inventor: MOORE RYAN G [US]


Application No.: US20080069898A1  Published: 20/Mar/2008

Title: Topical Compositions Comprising Myrica Gale Oil

Applicant/Assignee:

Application No.: 11/719064   Filing Date: 05/Jan/2005

Abstract:The use of Myrica gale oil in the manufacture of a composition for the treatment of the skin or other exposed surfaces of the body is disclosed. Compositons prepared in accordance with the invention are particularly useful as anti-acne and anti-dandruff products. Myrica gale oil may bai used with other active agents which have complementary benefits.

Priority: GB20040024891 Applic. Date: 2004-11-11; WO2005GB00016 Applic. Date: 2005-01-05

Inventor: SMITH CHRISTOPHER F [GB]; GALLEY EDWARD [GB]; BENEST EILIDH R [GB]


Application No.: US20080070864A1  Published: 20/Mar/2008

Title: Quinazolinone Modulators Of Nuclear Receptors

Applicant/Assignee: X-CEPTOR THERAPEUTICS, INC

Application No.: 10/506721   Filing Date: 04/Mar/2003

Abstract:Compounds, pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, quinazolinones are provided for modulating the activity of farnesoid X receptor (FXR) and/or orphan nuclear receptors.

Priority: US20020363132P Applic. Date: 2002-03-07; WO2003US06793 Applic. Date: 2003-03-04

Inventor: MARTIN RICHARD [US]; KAHL JEFFREY D [US]; FLATT BRENTON T [US]; GRIFFITH RONALD [US]


Application No.: US20080070874A1  Published: 20/Mar/2008

Title: Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes

Applicant/Assignee:

Application No.: 11/881214   Filing Date: 26/Jul/2007

Abstract:Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administering, topically or systemically, at least one of (i) an inhibitor of the matrix degrading enzymes and (ii) a cytokine inhibitor that alleviates inflammation and thus also alleviate neutrophil infiltration. Alleviating the matrix degradation and renormalizing procollagen biosynthesis allows for reduced inflammation and better natural repair of acne-affected skin. Inhibiting cytokines alleviates induction of MMPs in resident skin cells, and also alleviates inflammation with its concommitant induction of neutrophils from the blood stream bringing MMPs and elastase into the acne lesion. Diminishing the presence of matrix-degrading enzymes in the acne lesion reduces imperfect repair of the skin and thus decreases scarring in acne-affected skin.

Priority: US2005-169072 Applic. Date: 2005-06-27; US2000-576597 Applic. Date: 2000-05-22; US19990134984P Applic. Date: 1999-05-20

Inventor: VOORHEES JOHN J [US]; FISHER GARY J [US]; KANG SEWON [US]


Application No.: US20080072628A1  Published: 27/Mar/2008

Title: Kind of Yarn of Leather and Its Production Process

Applicant/Assignee: TIANWEI TEXTILE TECHNOLOGY (SHENZHEN) CO., LTD

Application No.: 11/571882   Filing Date: 21/Mar/2003

Abstract:This Invention provides a kind of leather yarn and its process of production, wherein the yarn is made of 1 (approx.) 100% WT of leather fiber, being mechanically opened from leather, and 0 (approx.) 99% WT of textile fiber. Leather fiber and textile fiber are disposed longitudinally, interlaced with each other and twisted together to form leather yarn. Process of making yarn of leather fiber is as follows: tanning animal pelage with conventional tanning process, then sorting, swelling, opening fiber, degumming, decoloring, edulcorating, grading, blending, clearing, carding, drawing, and spinning. This Invention can improve availability of animal pelage, broaden application field of animal pelage, and solve problems of low availability of animal pelage and reclamation and recycling of worn-out leather.

Priority: CN20041051407 Applic. Date: 2004-09-09; WO2005CN00350 Applic. Date: 2005-03-21

Inventor: LIU LIJIN [CN]


Application No.: US20080075684A1  Published: 27/Mar/2008

Title: Keratin-Binding Polypeptides

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/597815   Filing Date: 22/Nov/2006

Abstract:The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

Priority: DE200410025805 Applic. Date: 2004-05-24; DE200510011988 Applic. Date: 2005-03-14; WO2005EP05599 Applic. Date: 2005-05-24

Inventor: BARG HEIKO [DE]; SUBKOWSKI THOMAS [DE]; LEMAIRE HANS-GEORG [DE]; BOLLSCHWEILER CLAUS [DE]; PTOCK ARNE [DE]


Application No.: US20080075689A1  Published: 27/Mar/2008

Title: Aqueous Preparations Comprising at Least One Water-Soluble or Water-Dispersible Copolymer with Cationgenic Groups

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/629885   Filing Date: 15/Jun/2005

Abstract:The present invention relates to aqueous preparations comprising at least one water-soluble or water-dispersible copolymer with cationogenic groups which comprises at least one monomer with at least one protonatable nitrogen atom and at least one further monomer copolymerizable therewith in copolymerized form, and at least one cosmetically acceptable carrier, where the pH of the aqueous preparation has a value in the range from pH 4 to pH 6.

Priority: DE200410029773 Applic. Date: 2004-06-21; DE200510009668 Applic. Date: 2005-02-28; DE200510010108 Applic. Date: 2005-03-02; WO2005EP06401 Applic. Date: 2005-06-15

Inventor: PIEROBON MARIANNA [DE]; KIM SON N [DE]; HOSSEL PETER [DE]


Application No.: US20080075691A1  Published: 27/Mar/2008

Title: Permucosal Composition and Method of Improving Permucosal Absorption

Applicant/Assignee: OTSUKA PHARMACEUTICAL CO., LTD

Application No.: 11/662094   Filing Date: 12/Sep/2005

Abstract:An object of the invention is to provide a composition for transmucosal administration that enables pharmacologically active peptides and proteins to be efficiently absorbed through the mucosa such as the pulmonary mucosa, nasal mucosa, oral mucosa, vaginal mucosa, gastric mucosa, gastrointestinal mucosa or the like. A composition for transmucosal administration are prepared by adding (i) at least one member selected from the group consisting of peptides and proteins having pharmacological activity

and (ii) at least one member selected from the group consisting of chitosan oligosaccharides having a polymerization degree of from 2 to 20, derivatives thereof, glucosamine, and salts thereof.

Priority: JP20040268891 Applic. Date: 2004-09-15; WO2005JP16739 Applic. Date: 2005-09-12

Inventor: YAMAMOTO AKIRA [JP]; YAMADA KEIGO [JP]


Application No.: US20080075707A1  Published: 27/Mar/2008

Title: Use of placental alkaline phosphatase to promote skin cell proliferation

Applicant/Assignee: ESSENTIAL SKINCARE, LLC

Application No.: 11/528172   Filing Date: 27/Sep/2006

Abstract:Methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of undamaged mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective amount of human placental alkaline phosphatase, or an active derivative. The composition can be administered topically or by injection. Embodiments of the invention also provide regimens for restoring or maintaining the strength and thickness of aging skin, comprising periodically administering a composition by topical application. Other embodiments of the invention further provide methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of transplanted skin. A composition for topical application is also provided by some embodiments of the invention.

Priority:

Inventor: KISS ZOLTAN [US]


Application No.: US20080075798A1  Published: 27/Mar/2008

Title: Personal care compositions comprising pear seed extract

Applicant/Assignee:

Application No.: 11/897083   Filing Date: 29/Aug/2007

Abstract:Personal care compositions comprising an active component, use of such compositions, and methods of marketing such compositions. In one embodiment, the active component comprises pear seed extract. The personal care compositions can be applied topically, ingested orally, injected, or used as part of a regimen.

Priority: US20060841080P Applic. Date: 2006-08-30

Inventor: OSBORNE ROSEMARIE [US]; MULLINS LISA A [US]; EICKHOFF DAVID J [US]; ROBINSON LARRY R [US]; FINLAY DEBORAH R [US]


Application No.: US20080076720A1  Published: 27/Mar/2008

Title: Personal care compositions having kinetin or zeatin

Applicant/Assignee:

Application No.: 11/804802   Filing Date: 21/May/2007

Abstract:A personal care composition may comprise a member selected from a group consisting of kinetin, zeatin, and combinations thereof

niacinamide

and a dermatologically-acceptable carrier. A personal care composition may comprise an N-acyl amino acid compound, a skin care active, a member selected from a group consisting of kinetin, zeatin, and combinations thereof, and a dermatologically-acceptable carrier. A personal care composition may comprise a hexamidine compound, a skin care active, a member selected from a group consisting of kinetin, zeatin, and combinations thereof, and a dermatologically acceptable carrier.

Priority: US2006-482314 Applic. Date: 2006-07-07; US2003-627533 Applic. Date: 2003-07-25; US2004-977848 Applic. Date: 2004-10-29; US2004-780267 Applic. Date: 2004-02-17; US2003-379252 Applic. Date: 2003-03-04; US20050697819P Applic. Date: 2005-07-08; US20030516502P Applic. Date: 2003-10-31

Inventor: XIE SANCAI [US]; SREEKRISHNA KOTIKANYADANAM [US]; NEWLAND ABBY B [US]; BASCOM CHARLES C [US]; KACZVINSKY JOSEPH R JR [US]; LAMMERS KAREN MARIE [US]; VANOOSTHUYZE KRISTINA E I [GB]; BISSETT DONALD L [US]; ROBINSON LARRY R [US]; OSBORNE ROSEMARIE [US]; TANNER PAUL R [US]


Application No.: US20080076755A1  Published: 27/Mar/2008

Title: Anti-Inflammatory Agents

Applicant/Assignee: CAMBRIDGE ENTERPRISE LIMITED

Application No.: 11/573851   Filing Date: 10/Aug/2005

Abstract:The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein y is any integer from 1 to 8

z is any integer from 1 to 8

with the proviso that y and z cannot both equal 1

X is -C -(Y)k-(R<1>)n or SO2-(Y)k (R<1>)n

k is 0 or 1

Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group)

or Y is a cycloalkenyl or polycycloalkenyl group.

Priority: GB20040018375 Applic. Date: 2004-08-18; WO2005GB03139 Applic. Date: 2005-08-10

Inventor: GRAINGER DAVID J [GB]; FOX DAVID J [GB]


Application No.: US20080076758A1  Published: 27/Mar/2008

Title: Pharmaceutical compounds

Applicant/Assignee: PIRAMED LIMITED GENENTECH, INC

Application No.: 11/789468   Filing Date: 24/Apr/2007

Abstract:Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Priority: US20060795048P Applic. Date: 2006-04-26

Inventor: FOLKES ADRIAN [GB]; SHUTTLEWORTH STEPHEN [GB]; CHUCKOWREE IRINA [GB]; OXENFORD SALLY [GB]; WAN NAN CHI [GB]; CASTANEDO GEORGETTE [US]; GOLDSMITH RICHARD [US]; GUNZNER JANET [US]; HEFFRON TIM [US]; MATHIEU SIMON [US]; OLIVERO ALAN [US]; SUTHERLIN DANIEL P [US]; ZHU BING-YAN [US]


Application No.: US20080076768A1  Published: 27/Mar/2008

Title: Pharmaceutical compounds

Applicant/Assignee: PIRAMED LIMITED

Application No.: 11/789423   Filing Date: 24/Apr/2007

Abstract:A thienopyrimidine of formula (I): and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110alpha subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.

Priority: US20060794966P Applic. Date: 2006-04-26

Inventor: CHUCKOWREE IRINA [GB]; FOLKES ADRIAN [GB]; HANCOX TIM [GB]; SHUTTLEWORTH STEPHEN [GB]


Application No.: US20080076831A1  Published: 27/Mar/2008

Title: Hemorrhoid reliever and method of use

Applicant/Assignee:

Application No.: 11/525357   Filing Date: 22/Sep/2006

Abstract:A composition containing chlorhexidine enabling treatment of many types of discomforts, including hemorrhoid pain and itching without discomfort.

Priority:

Inventor: GOETZ BERNARD [US]


Application No.: US20080078043A1  Published: 03/Apr/2008

Title: SELF-CLEANING HAIR BRUSH WITH REPLACEABLE PRELOADED BRISTLE MAT

Applicant/Assignee: THE HARTZ MOUNTAIN CORPORATION

Application No.: 11/925152   Filing Date: 26/Oct/2007

Abstract:A brush for hygienic purposes includes a handle with a lower and an upper portion and a head. The upper portion is sized and shaped to capture the head. Preferably the head is a removable cartridge and includes a flexible base with a plurality bristles and a pad with holes disposed over the bristles. The pad could be a foam or sponge matrix or could be a stack of sheets removable one at a time. Upper portion of the handle is curved to provide a predetermined shape to the head. Optionally, a vibrating device is incorporated in the brush so that the brush can be used as to massage the skin or scalp.

Priority: US2007-702902 Applic. Date: 2007-02-06; US2006-480149 Applic. Date: 2006-06-30; US20060774054P Applic. Date: 2006-02-16; US20060771142P Applic. Date: 2006-02-07

Inventor: MCKAY WILLIAM D [US]


Application No.: US20080081024A1  Published: 03/Apr/2008

Title: Photoprotective compositions comprising synergistic combination of sunscreen active compounds

Applicant/Assignee:

Application No.: 11/541763   Filing Date: 02/Oct/2006

Abstract:Compositions for topical application to skin and/or hair, comprising photoprotecting synergistically effective amounts of sunscreen active agents octinoxate, octocrylene, and amiloxate

methods of protecting skin and/or hair against deleterious effects of sunlight/UV radiation by topical application of compositions.

Priority:

Inventor: BEASLEY DONATHAN G [US]; MEYER THOMAS A [US]


Application No.: US20080081077A1  Published: 03/Apr/2008

Title: Method of wound/burn healing using copper-zinc compositions

Applicant/Assignee:

Application No.: 11/648278   Filing Date: 29/Dec/2006

Abstract:Composition and methods for alleviating or eliminating wounds and/burns by providing an effective amount of one or more copper, zinc and copper-zinc compositions are disclosed. Treatment is accomplished through the use of topical compositions containing one or more copper or zinc salts and/or copper-zinc compounds or complexes, particularly copper-zinc malonate active ingredient.

Priority: US20060848616P Applic. Date: 2006-09-28

Inventor: FARYNIARZ JOSEPH R [US]; RAMIREZ JOSE E [US]


Application No.: US20080081811A1  Published: 03/Apr/2008

Title: Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton

Applicant/Assignee: BANYU PHARMACEUTICAL CO., LTD

Application No.: 11/596735   Filing Date: 19/May/2005

Abstract:The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2

Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N

however, at least one of Y1, Y2, Y3, Y4 and Y5 is N

Z1 and Z2, which may be identical or different, are each CH or N

n is an integer from 1 to 3

R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group

R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like

and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

Priority: JP20040178974 Applic. Date: 2004-05-21; WO2005JP09593 Applic. Date: 2005-05-19

Inventor: IWASAWA YOSHIKAZU [JP]; SHIBATA JUN [JP]; SHIMAMURA TADASHI [JP]; KURIHARA HIDEKI [JP]; MITA TAKASHI [JP]; KAWANISHI NOBUHIKO [JP]; HASHIHAYATA TAKASHI [JP]; KAWAMURA MIKAKO [JP]; SAGARA TAKESHI [JP]; ARAI SACHIE [JP]; HIRAI HIROSHI [JP]


Application No.: US20080085260A1  Published: 10/Apr/2008

Title: Formulation for repelling insects and attracting fish

Applicant/Assignee:

Application No.: 11/973924   Filing Date: 10/Oct/2007

Abstract:Disclosed is a novel formulation and process for the effective repelling of insects without the adverse effects of repelling fish. Further the formulation is stable enough for long term storage, has a high rate of durability on the skin, and has been shown in cases to attract fish.

Priority: US20060828954P Applic. Date: 2006-10-10

Inventor: TINGHITELLA MICHAEL [US]


Application No.: US20080085263A1  Published: 10/Apr/2008

Title: Liquid Depot Formulations

Applicant/Assignee:

Application No.: 11/628007   Filing Date: 06/Jun/2005

Abstract:the present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol

b) at least one phospholipid

c) at least one biocompatible, oxygen containing, low viscosity organic solvent

wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Priority: GB20040012530 Applic. Date: 2004-06-04; GB20050000807 Applic. Date: 2005-01-14; GB20050007811 Applic. Date: 2005-04-18; WO2005GB02217 Applic. Date: 2005-06-06

Inventor: THURESSON KRISTER [SE]; TIBERG FREDRIK [SE]; JOHANSSON MARKUS [SE]; HARWIGSSON IAN [SE]; JOABSSON FREDRIK [SE]


Application No.: US20080085278A1  Published: 10/Apr/2008

Title: BINDING MEMBER WHICH BINDS TO BOTH LEWIS-Y AND LEWIS-B HAPTENS, AND ITS USE FOR TREATING CANCER

Applicant/Assignee: SCANCELL LIMITED

Application No.: 11/831125   Filing Date: 31/Jul/2007

Abstract:The invention relates to the use of a binding member which binds to Lewisand Lewis haptens in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to Lewisand Lewis haptens and cancer cells and induces cells death.

Priority: GB20010011628 Applic. Date: 2001-05-11; US2002-476233 Applic. Date: 2002-05-10; WO2002GB02182 Applic. Date: 2002-05-10

Inventor: DURRANT LINDA G [GB]; PARSONS TINA [GB]


Application No.: US20080085858A1  Published: 10/Apr/2008

Title: Pharmaceutical Composition

Applicant/Assignee: KYOWA HAKKO KOGYO CO., LTD

Application No.: 11/576970   Filing Date: 13/Oct/2005

Abstract:The present invention provides a pharmaceutical composition comprising (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, a therapeutic and/or preventive agent for chronic skin diseases comprising (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, a therapeutic and/or preventive agent for chronic skin diseases to be administered simultaneously or separately with an interval comprising (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) an immunosuppressant, as active ingredients

and the like.

Priority: JP20040299104 Applic. Date: 2004-10-13; JP20050113265 Applic. Date: 2005-04-11; WO2005JP18854 Applic. Date: 2005-10-13

Inventor: HARADA DAISUKE [JP]; KOBAYASHI KATSUYA [JP]; MANABE HARUHIKO [JP]; OHSHIMA ETSUO [JP]


Application No.: US20080085961A1  Published: 10/Apr/2008

Title: Novel natural oil gels and their applications

Applicant/Assignee: APPLECHEM, INC

Application No.: 11/973826   Filing Date: 09/Oct/2007

Abstract:The invention is an article of manufacture, comprising a blend of: (A) from 1 to 50 weight percent of at least one block copolymer, wherein the block copolymer has at least one polystyrene block and at least one unsaturated rubber segment

and (B) from 99 to 50 weight percent of a natural oil. The natural oil of this invention is of natural animal, plant or vegetable oils or mixtures thereof, and the block copolymers have a polystyrene block and a rubber block where the rubber blocks are unsaturated rubbers such as polyisoprene, polybutadiene, or mixtures thereof. The block copolymers useful for the present invention are triblock polymers, radial (star) polymers, multiblock polymers, diblock polymers, or mixtures thereof.

Priority: US20060850586P Applic. Date: 2006-10-10; US20070900512P Applic. Date: 2007-02-09; US20070900518P Applic. Date: 2007-02-09

Inventor: LIN SAMUEL [US]


Application No.: US20080089850A1  Published: 17/Apr/2008

Title: Compositions Comprising Combinations of Sensates

Applicant/Assignee:

Application No.: 11/548586   Filing Date: 11/Oct/2006

Abstract:Compositions comprising a first sensate, a second sensate, and a cationic polymeric compound are described, as well as methods for using such compositions in oral care and personal care applications.

Priority:

Inventor: HASKEL ARIEL [US]; HARMALKER SUBHASH [US]; MATTAI JAIRAJH [US]


Application No.: US20080089851A1  Published: 17/Apr/2008

Title: Brown Algae Cell Lyophilisate, Method For The Obtention Thereof

Applicant/Assignee: BIOTECHMARINE

Application No.: 11/813861   Filing Date: 14/Dec/2005

Abstract:This invention is related to a freeze-dried product of cells of brown algae, the process for obtaining thereof, a cosmetic composition containing thereof, a food complement containing thereof, and the use thereof.

Priority: FR20050000389 Applic. Date: 2005-01-14; WO2005FR03125 Applic. Date: 2005-12-14

Inventor: MEKIDECHE NICOLE [FR]


Application No.: US20080089853A1  Published: 17/Apr/2008

Title: Amphoteric Ethyl Methacrylate Copolymers and Use Thereof

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/665898   Filing Date: 19/Oct/2005

Abstract:The present invention relates to amphoteric copolymers which comprise ethyl methacrylate, if appropriate a N-vinyllactam compound, at least one monoethylenically unsaturated carboxylic acid and at least one compound with alpha,beta-ethylenically unsaturated double bond and at least one cationogenic and/or cationic group in copolymerized form, to cosmetic and pharmaceutical compositions which comprise such copolymers, to preparation methods, and to the use of these copolymers.

Priority: DE200410051541 Applic. Date: 2004-10-22; WO2005EP11241 Applic. Date: 2005-10-19

Inventor: NGUYEN-KIM SON [DE]; WINTER GABI [DE]; LAUBENDER MATTHIAS [DE]


Application No.: US20080089870A1  Published: 17/Apr/2008

Title: Cultured Melanocytes on Bioploymer Membranes for Treatment of Hyper and Hypopigmentation Disorders

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD

Application No.: 11/872431   Filing Date: 15/Oct/2007

Abstract:The present invention relates to a graft wherein cultured autologous melanocytes are delivered using a biopolymer. The present invention describes the composition, method of preparation and its properties relating to safety and efficacy. The graft of the present invention has a potential use in treating hyper- and hypopigmentation disorders.

Priority: IN2006MU01697 Applic. Date: 2006-10-13

Inventor: GHOSH DEEPA [IN]; SHENOY SUDHEER [IN]; KUCHROO PUSHPA [IN]; SHAH VIRU [IN]


Application No.: US20080089906A1  Published: 17/Apr/2008

Title: Use of substances to protect FGF-2 or FGF-beta growth factor

Applicant/Assignee:

Application No.: 11/803805   Filing Date: 16/May/2007

Abstract:The invention relates to substances which are capable of protecting FGF-2, to a composition for preventing or controlling degradation of FGF-2, and a method of protecting FGF-2 in the skin from degradation. In particular, the invention relates to an extract of Hibiscus Abelmoschus or ambrette, a rebokza extract, a gougizi berry extract, a banha extract, a lessonia extract, a mustard flour extract, a wooyin extract, a barley extract, and/or a sesame extract, in amounts effective to protect FGF-2 from its degradation. Further, the present invention allows the extracellular matrix to be restructured, particularly at the dermis, which is useful, for example, for controlling aging.

Priority: FR20060054316 Applic. Date: 2006-10-17; FR20070054725 Applic. Date: 2007-04-26

Inventor: RIVAL DELPHINE [FR]; BONNET SEBASTIEN [FR]; ORLY ISABELLE [FR]; PERRIER ERIC [FR]


Application No.: US20080089913A1  Published: 17/Apr/2008

Title: Capsule Whose Envelope Is Separately Imperceptible During The Topical Use Thereof

Applicant/Assignee: BEIERSDORF AG

Application No.: 10/569382   Filing Date: 27/Aug/2004

Abstract:A capsule for cosmetic and/or dermatological ingredients and processes for the production thereof. The capsule comprises an envelope which is solid, semisolid and/or dimensionally stable and comprises one or more substances which are selected from waxes, emulsifiers, and natural and synthetic polymers. The capsule may also comprise a filling.

Priority: DE20031039747 Applic. Date: 2003-08-27; DE20031040106 Applic. Date: 2003-08-30; DE20031057639 Applic. Date: 2003-12-10; WO2004EP09563 Applic. Date: 2004-08-27

Inventor: KALLMAYER VOLKER [DE]; NIELSEN JEANS [DE]; BLECKMANN ANDREAS [DE]; RIEDEL HEIDI [DE]; ECKERT JULIA [DE]; RASCHKE THOMAS [DE]; TEUBER FRANK [DE]; ZU PUTLITZ CORINNA [DE]; CONZELMANN STEPHANIE [DE]; LISTE KATHRIN [DE]; KRUSE UTA [DE]; ECKHARD YVONNE [DE]


Application No.: US20080089921A1  Published: 17/Apr/2008

Title: APPARATUS FOR PIEZOELECTRIC LAYER-WISE PUMP AND VALVE FOR USE IN LOCAL ADMINISTRATION OF BIOLOGICAL RESPONSE MODIFIERS AND THERAPEUTIC AGENTS

Applicant/Assignee: PHARMACO KINESIS CORP PHARMACO KINESIS CORPORATION

Application No.: 11/959419   Filing Date: 18/Dec/2007

Abstract:A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment.

Desired dosing and scheduling of anti-tumor agents in a local setting is provided In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery. In one embodiment, reporting the events in the tumor site via an RF link to the external control box is provided.

Priority: US2003-614685 Applic. Date: 2003-07-03; US20020393933P Applic. Date: 2002-07-03

Inventor: SHACHAR YEHOSHUA [US]


Application No.: US20080089946A1  Published: 17/Apr/2008

Title: Synergistic Phytoceutical Compositions

Applicant/Assignee:

Application No.: 11/924122   Filing Date: 25/Oct/2007

Abstract:Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.

Priority: US2005-271940 Applic. Date: 2005-11-10

Inventor: OLALDE RANGEL JOSE A [VE]


Application No.: US20080090758A1  Published: 17/Apr/2008

Title: CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF

Applicant/Assignee: AETERNA ZENTARIS GMBH

Application No.: 11/850747   Filing Date: 06/Sep/2007

Abstract:The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

Priority: EP20060018750 Applic. Date: 2006-09-07; US20060842357P Applic. Date: 2006-09-06

Inventor: GUENTHER ECKHARD [DE]; SCHAEFER OLAF [DE]; TEIFEL MICHAEL [DE]; PAULINI KLAUS [DE]


Application No.: US20080090760A1  Published: 30/Aug/2007

Title: Compositions and methods for inhibiting cellular proliferation

Applicant/Assignee:

Application No.: 11/636353   Filing Date: 08/Dec/2006

Abstract:Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis.

Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.

Priority: US20050749276P Applic. Date: 2005-12-09

Inventor: HOLMES CHRISTOPHER P [US]; YIN QUN [US]; ZEMEDE GENET H [US]; ANGELL YVONNE M [US]; FREDERICK BRIAN T [US]; XU CAIDING [US]


Application No.: US20080090772A1  Published: 17/Apr/2008

Title: Oligosaccharide Aldonic Acids and Their Topical Use

Applicant/Assignee:

Application No.: 11/872459   Filing Date: 15/Oct/2007

Abstract:Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and/or extrinsic aging, as well as with changes or damage caused by extrinsic factors

general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa

for general oral care, as well as treatment and prevention of oral and gum diseases

and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Priority: US2004-811998 Applic. Date: 2004-03-30; US2001-987023 Applic. Date: 2001-11-13; US2000-487228 Applic. Date: 2000-01-19; US19990141264P Applic. Date: 1999-06-30

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]


Application No.: US20080090841A1  Published: 17/Apr/2008

Title: METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES

Applicant/Assignee: PARION SCIENCES, INC

Application No.: 11/851803   Filing Date: 07/Sep/2007

Abstract:The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.

Priority: US20060845171P Applic. Date: 2006-09-18; US20060842669P Applic. Date: 2006-09-07

Inventor: JOHNSON MICHAEL R [US]; BOUCHER RICHARD C [US]; HIRSH ANDREW J [US]


Application No.: US20080090916A1  Published: 17/Apr/2008

Title: Compounds for Treating Urinary Incontinence

Applicant/Assignee:

Application No.: 11/795453   Filing Date: 25/Jan/2006

Abstract:The invention relates to compounds of formula (I) or a pharmaceutically acceptable solvate or salt thereof, including a solvate of such a salt, wherein R<1 >is a group such that a compound of formula (I) is a prodrug of 1R,2S-methoxamine that is converted within the kidney tubules into its active form or an active metabolite thereof. The compounds find particular use in the treatment or prophylaxis of urinary incontinence.

Priority: GB20050001580 Applic. Date: 2005-01-25; WO2006GB00256 Applic. Date: 2006-01-25

Inventor: THOMPSON JEFFREY M [GB]; GRUSS HANS J [GB]; UNGAR ALEXANDER [GB]


Application No.: US20080095731A1  Published: 24/Apr/2008

Title: Personal Care Compositions Comprising Alpha-Glucans and/or Beta-Glucans

Applicant/Assignee:

Application No.: 11/961232   Filing Date: 20/Dec/2007

Abstract:Personal care compositions containing at an alpha-glucan and/or beta-glucan

at least one additional skin and/or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof

and a dermatologically acceptable carrier.

Priority: WO2006US23470 Applic. Date: 2006-06-14; US20050692643P Applic. Date: 2005-06-21; US20050696312P Applic. Date: 2005-07-01

Inventor: MITRA SHEKHAR [US]


Application No.: US20080095735A1  Published: 24/Apr/2008

Title: Skin-Protective Polymer For Use In Teat Care Compositions

Applicant/Assignee:

Application No.: 11/795454   Filing Date: 31/Jan/2005

Abstract:This invention relates generally to the field of antimicrobial teat care compositions. More particularly, it relates to a skin-adhering antimicrobial composition comprising a copolymer which contains methacrylic acid and 2-acrylamido-2-methyl-propane sulfonic acid (AMPS) monomeric units, the antimicrobial composition hindering the transfer of bacteria from the environment to underlying teat surfaces and orifices, and which is compatible with both mammalian tissue, including skin, and teat dip compositions.

Priority: WO2005US02906 Applic. Date: 2005-01-31

Inventor: KROSS ROBERT D [US]


Application No.: US20080095806A1  Published: 24/Apr/2008

Title: Composition And Method For Treating Inflammatory Diseases Using Protease Inhibitors

Applicant/Assignee:

Application No.: 10/535609   Filing Date: 20/Nov/2003

Abstract:Compositions containing a protease inhibitor and methods of use and production are described. The compositions contain an effective amount of a protease inhibitor in a carrier or diluent and are used for the treatment of inflammatory or hyperproliferic mucocutaneous disorders. The carrier or diluent is preferably a gelling agent, and the composition is a topical gel formulation containing alpha 1 -antitrypsin in an aqueous liquid or viscous gel formulation.

Priority: US20020427702P Applic. Date: 2002-11-20; WO2003GB05049 Applic. Date: 2003-11-20

Inventor: BATHURST IAN C [US]; PEMBERTON PHILIP A [US]; SUNDIN DAVID J [US]; MAYHEW JAMES W [US]; ANGEL ARTURO J [US]; BARR PHILIP J [US]


Application No.: US20080095810A1  Published: 24/Apr/2008

Title: Nanoparticles Of Chitosan And Polyethyleneglycol As A System For The Administration Of Biologically-Active Molecules

Applicant/Assignee: ADVANCED IN VITRO CELL TECHNOLOGIES, S.L

Application No.: 11/908599   Filing Date: 14/Mar/2006

Abstract:The present invention relates to nanoparticle systems for the release of biologically active molecules formed by the chitosan polymer or its derivatives, chemically modified with polyethylene glycol and crosslinked with a crosslinking agent. These systems are especially useful for pharmaceutical compositions, vaccines and cosmetic formulations.

Priority: ES20050000590 Applic. Date: 2005-03-14; WO2006ES00123 Applic. Date: 2006-03-14

Inventor: ALONSO FERNANDEZ MA J [ES]; JANES KEVIN [ES]; CSABA NOEMI [ES]


Application No.: US20080095812A1  Published: 24/Apr/2008

Title: Systems providing antimicrobial activity to an environment

Applicant/Assignee: BIOLARGO LIFE TECHNOLOGIES, INC

Application No.: 11/973933   Filing Date: 11/Oct/2007

Abstract:A process reduces the microbial content in land mass by providing molecular iodine in the land mass in a concentration in aqueous material in the land mass of at least 5 or 10 parts per million. The molecular iodine may be added in gaseous or liquid or solid state, and may be formed in situ using available water, added water and/or alcohol in the reaction.

Priority: US20060850976P Applic. Date: 2006-10-11

Inventor: CODE KENNETH R [CA]


Application No.: US20080095831A1  Published: 24/Apr/2008

Title: TOPICAL FORMULATION OF MULTILAMELLAR VESICLES COMPOSITION FOR PERCUTANEOUS ABSORPTION OF PHARMACEUTICALLY ACTIVE AGENT

Applicant/Assignee:

Application No.: 11/463646   Filing Date: 10/Aug/2006

Abstract:A composition of multilamellar vesicles for the delivery of pharmaceutically-active substances through the skin of a mammal, the composition including between about 1 to about 30% Cyclomethicone 5-.N.F., between about 1 to about 30% PEG-12 Dimethicone

between about 3 to about 14% Cyclopentasiloxane and PEG 12 Dimethicone Crosspolymers, between about 0.9 to about 9% Lauryl PEG/PPG-18/18 Methicone, between about 2 to 5% Sepigel 305, between about 1 to about 4%, Carbopol ETD 2020 solution (2%), up to 100% Water, and Sodium hydroxide to a pH between about 6-6.5.

Priority:

Inventor: MC GRAW THOMAS L [US]


Application No.: US20080095848A1  Published: 24/Apr/2008

Title: Pharmaceutical Composition For Topical Use In Form Of Xerogels Or Films And Methods For Production

Applicant/Assignee: LUDWIG-MAXIMILIAN-UNIVERSITY

Application No.: 10/591098   Filing Date: 03/Mar/2005

Abstract:The present invention relates to dry delivery system comprising a xerogel or film with applied active ingredients for topical active ingredient delivery or other purposes. Said delivery system are obtainable by a method according to the invention. The present invention also provides for methods for achieving defined localization of stable or unstable active substances on dry xerogels or films, which can be reconstituted into hydrogels. From the obtained delivery systems, the active substances are released with advantageous release kinetics.

Priority: EP20040005008 Applic. Date: 2004-03-03; WO2005EP02261 Applic. Date: 2005-03-03

Inventor: STABENAU ANKE [DE]; WINTER GERHARD [DE]; SCHMIDT ROLAND [DE]


Application No.: US20080095861A1  Published: 24/Apr/2008

Title: Antimicrobial and sporicidal composition

Applicant/Assignee:

Application No.: 11/637602   Filing Date: 11/Dec/2006

Abstract:Germicidal compositions with enhanced activity towards killing microbiological spores and vetgetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.

Priority: US2003-346216 Applic. Date: 2003-01-16; US20020350416P Applic. Date: 2002-01-18

Inventor: WALKER EDWARD B [US]


Application No.: US20080095866A1  Published: 24/Apr/2008

Title: Topical Compositions Containing Phosphorylated Polyphenols

Applicant/Assignee: AJINOMOTO OMNICHEM S.A ESTEE LAUDER COORDINATION CENTER N.V

Application No.: 11/574252   Filing Date: 26/Feb/2007

Abstract:The present invention provides topical compositions containing phosphorylated polyphenols in combination with a topically acceptable carrier. The compositions of the invention provide a means for delayed delivery of the polyphenol to keratinous tissues, such as skin, hair and nails, with enzymes of the keratinous tissue dephosphorylating the polyphenol, and returning it to its native active form. The compositions are particularly useful in the regulation of skin conditions.

Priority: WO2004BE00132 Applic. Date: 2004-09-14

Inventor: DECLERCQ LIEVE [BE]; CORSTJENS HUGO [BE]; MAES DANIEL [US]; VAN BRUSSEL WILLY [BE]; SCHELKENS GEERT [BE]


Application No.: US20080096914A1  Published: 24/Apr/2008

Title: Tetrahydropyridothiophenes for the Treatment of Proliferative Diseases Such as Cancer

Applicant/Assignee: ALTANA PHARMA AG 4SC AG

Application No.: 11/883596   Filing Date: 08/Feb/2006

Abstract:Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Priority: EP20050100895 Applic. Date: 2005-02-09; EP20050104488 Applic. Date: 2005-05-25; EP20050112158 Applic. Date: 2005-12-14; WO2006EP50782 Applic. Date: 2006-02-08

Inventor: PEKARI KLAUS [DE]; SCHMIDT MATHIAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [DE]; BARTELS BJORN [DE]


Application No.: US20080096965A1  Published: 24/Apr/2008

Title: (Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators

Applicant/Assignee: NEWRON PHARMACEUTICALS S.P.A

Application No.: 11/574751   Filing Date: 28/Jul/2005

Abstract:The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

Priority: EP20040021525 Applic. Date: 2004-09-10; WO2005EP08200 Applic. Date: 2005-07-28

Inventor: BARBANTI ELENA [IT]; THALER FLORIAN [IT]; CACCIA CARLA [IT]; FARIELLO RUGGERO [IT]; SALVATI PARTRICIA [IT]


Application No.: US20080097423A1  Published: 24/Apr/2008

Title: Epilating Apparatus

Applicant/Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V

Application No.: 11/576376   Filing Date: 20/Sep/2005

Abstract:The present invention relates to an epilating apparatus ( 10 ) comprising means ( 12 ) for extracting hairs from skin and means ( 16, 20 ) for reducing pain. In accordance with the present invention the means ( 16, 20 ) for reducing pain apply at least two of the following stimuli: heat, cold, vibration.

Priority: EP20040104793 Applic. Date: 2004-09-30; WO2005IB53095 Applic. Date: 2005-09-20

Inventor: MOSER WOLFGANG [AT]; SAMONIGG GERT [AT]; SCHRETTLINGER JOACHIM [AT]


Application No.: US20080097559A1  Published: 24/Apr/2008

Title: Method and apparatus for carrying out the controlled heating of dermis and vascular tissue

Applicant/Assignee:

Application No.: 11/825902   Filing Date: 10/Jul/2007

Abstract:Method for effecting a controlled heating of tissue within the region of dermis which employs heater implants which are configured with a thermally insulative generally flat support functioning as a thermal barrier. From the surface of this thermal barrier are supported one or more electrodes within a radiofrequency excitable circuit as well as an associated temperature sensing circuit. A model of R.F. current path flow is developed resulting in a current path index permitting a prediction of current path flow. Improved electrode excitation is developed with an intermittent R.F. excitation of electrodes shortening therapy time and improving skin protection against thermal trauma.

Priority: US2006-583621 Applic. Date: 2006-10-19

Inventor: EGGERS PHILIP E [US]; EGGERS ANDREW R [US]; EGGERS ERIC A [US]


Application No.: US20080097607A1  Published: 24/Apr/2008

Title: Pigmentable epidermis equivalent prepared from matrix cells and methods for the production thereof

Applicant/Assignee: L'OREAL

Application No.: 11/826370   Filing Date: 13/Jul/2007

Abstract:Epidermis equivalents capable of pigmentation include cells derived from the differentiation of matrix cells

reconstructed skins comprised thereof, optionally containing hair follicles, are useful for evaluating the effect of topical cosmetic, pharmaceutical or dermatological products and may also be used for the preparation of grafts suited to be transplanted on mammals, more particularly on human patients such as victims of third-degree burns.

Priority: FR20060052984 Applic. Date: 2006-07-13; US20060832593P Applic. Date: 2006-07-24

Inventor: BAKKAR KHALID [FR]; ASSELINEAU DANIEL [FR]


Application No.: US20080102090A1  Published: 01/May/2008

Title: Pharmaceutical Compositon Containing Botulinum Neurotoxin A2

Applicant/Assignee:

Application No.: 11/659449   Filing Date: 03/Aug/2005

Abstract:A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics selected from the group consisting of

(a) a much longer duration of action

(b) a much faster rate of onset of muscular paralysis

(c) a significantly greater intramuscular safety margin

(d) a selective action on inhibition of smooth muscle contraction

(e) a selective action on inhibition of pain-related (nociceptive) nerve cell function: Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.

Priority: GB20040017367 Applic. Date: 2004-08-04; GB20040021288 Applic. Date: 2004-09-24; GB20040021290 Applic. Date: 2004-09-24; GB20040023950 Applic. Date: 2004-10-28; GB20040023953 Applic. Date: 2004-10-28; WO2005GB03057 Applic. Date: 2005-08-03

Inventor: PANJWANI NAVEED [GB]; WEBB PAUL [GB]; PICKETT ANDY [GB]


Application No.: US20080102106A1  Published: 01/May/2008

Title: Wound Healing Composition Comprising Substances From Diptera Larvae

Applicant/Assignee: ALPHA-BIOCARE GMBH

Application No.: 11/814193   Filing Date: 01/Dec/2006

Abstract:Disclosed is a wound healing composition comprising a mixture of substances that are obtained from diptera larvae, are heat-resistant at 100 DEG C., and have molecular weights ranging from 500 to 10,000 Dalton. Also, disclosed are the use of said composition as well as a method for the production thereof.

Priority: DE200510061246 Applic. Date: 2005-12-20; WO2006EP69210 Applic. Date: 2006-12-01

Inventor: D HAESE JOCHEN [DE]; MEHLHORN HEINZ [DE]; RUZICKA THOMAS [DE]; SCHMIDT JURGEN [DE]; STEGE HELGER [DE]


Application No.: US20080102157A1  Published: 01/May/2008

Title: Flavored chewable foams and a process for their production

Applicant/Assignee:

Application No.: 11/586099   Filing Date: 25/Oct/2006

Abstract:Flavored chewable foams for the oral care sector are produced from a polyurethane-polyurea and a sensorially active substance (e.g., taste substance and/or aroma substance) by foaming a polyurethane-urea dispersion, drying that dispersion and incorporating the sensorially active substance into the polyurethane-urea dispersion before, during or after foaming of the dispersion.

Priority:

Inventor: HOFACKER STEFFEN [DE]; FELLER THOMAS [DE]; MICHAELIS THOMAS [DE]; DOERR SEBASTIAN [DE]; SCHWANNECKE DIRK [US]


Application No.: US20080103184A1  Published: 01/May/2008

Title: COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 11/967423   Filing Date: 31/Dec/2007

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2005-138097 Applic. Date: 2005-05-26; US2001-774557 Applic. Date: 2001-01-31; US20000193645P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL A [US]; MCIVER JOHN M [US]; YOUNGQUIST ROBERT S [US]


Application No.: US20080103460A1  Published: 01/May/2008

Title: Method for making an appliance for delivering a composition, the appliance having an elastic layer and a shielding layer

Applicant/Assignee:

Application No.: 11/590443   Filing Date: 31/Oct/2006

Abstract:Disclosed is a method for making an appliance adapted to transfer to, or associate with, the skin or tissue of a user, a composition, e.g., a moisturizing formulation. Because of possible interactions between the formulation and/or formulation ingredients and elastic polymers that may be employed to help give the appliance elastic qualities, the method comprises steps for providing an elastic layer or member and a shielding layer or member, with the shielding member interposed between the composition/formulation and the elastic member. The shielding layer and elastic layer may be integrally connected to one another, as in a film comprising two layers. Typically the shielding layer will be impermeable to the composition/formulation (e.g., by employing polymers, such as polypropylene comprising crystalline portions, such that the mass transport of the formulation through the shielding member is stopped or substantially impeded).

Priority:

Inventor: CLOSE KENNETH B [US]; ARENDT JONATHAN K [US]; ANDERSON GARY V [US]


Application No.: US20080104787A1  Published: 08/May/2008

Title: Motorized personal skin care implement

Applicant/Assignee: CONOPCO INC., D/B/A UNILEVER

Application No.: 11/591954   Filing Date: 02/Nov/2006

Abstract:A motorized personal skin care implement capable of use with a disposable, single-use, skin care pad is disclosed with a molded hook arrangement for releasably but firmly holding the pad while cleansing or treating the skin but allowing for quick removal and replacement with a fresh cleansing or treatment pad. A method of using the skin care implement and a kit containing at least one pad and the implement is also described.

Priority:

Inventor: KEENAN DIANE MARIE [US]; MURRAY LIAM ANTHONY [US]; WILLIAMS DAVID ROBERT [US]; BRENNAN MICHAEL AUGUSTINE [US]


Application No.: US20080107677A1  Published: 08/May/2008

Title: DERMAL DROPS

Applicant/Assignee:

Application No.: 11/836375   Filing Date: 09/Aug/2007

Abstract:Dermal drops that, when applied topically to animal subjects, can ameliorate symptoms of conditions such as diabetes and Parkinson's disease are prepared as concentrates of the culture filtrate of a Basidiomycete fungus grown under appropriate conditions. The concentrate can also be used as a convenient source of liquid compost factor.

Priority: US20060837159P Applic. Date: 2006-08-10

Inventor: HIROMOTO BRYAN [US]


Application No.: US20080107720A1  Published: 08/May/2008

Title: Topical delivery of codrugs

Applicant/Assignee: PSIVIDA, INC

Application No.: 12/006596   Filing Date: 04/Jan/2008

Abstract:The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.

Priority: US2006-636774 Applic. Date: 2006-12-11; US2002-299597 Applic. Date: 2002-11-19; US20010331512P Applic. Date: 2001-11-19

Inventor: WALTERS KENNETH A [GB]; SHIMIZU ROBERT [US]; ASHTON PAUL [US]; CYNKOWSKA GRAZYNA [US]; CYNKOWSKI TADEUSZ [US]; GAUTHIER ERIC [US]


Application No.: US20080107747A1  Published: 08/May/2008

Title: Pain relief composition

Applicant/Assignee:

Application No.: 12/004336   Filing Date: 18/Dec/2007

Abstract:Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles

an effective amount of a cooling component

an effective amount of a heat minimizing or blocking component

an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves

and an effective amount of a soothing and anti-inflammatory complex for the joints and/or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.

Priority: WO2006US41288 Applic. Date: 2006-10-23

Inventor: ROEDERER JOY E [US]


Application No.: US20080107761A1  Published: 08/May/2008

Title: Composition and Method For Promoting the Production of and/or Enhancing the Activity of Fibulin-5

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 11/792604   Filing Date: 16/Dec/2005

Abstract:There is provided a composition for promoting the production of and/or enhancing the activity of fibulin-5, said composition comprising as an active ingredient one or a plurality of pharmaceutical agents selected from the group consisting of extracts of Caesalpinia crista, extracts of Psophocarpus tetragonolobus, phytic acid and a pharmaceutically acceptable salt thereof, and L- hydroxyproline and a pharmaceutically acceptable salt thereof.

Priority: JP20040365935 Applic. Date: 2004-12-17; WO2005JP23553 Applic. Date: 2005-12-16

Inventor: OGURA YUKI [JP]; AMANO SATOSHI [JP]; SONEHARA NOBUKO [JP]


Application No.: US20080111005A1  Published: 15/May/2008

Title: Water-Based Antiperspirant and Aerosol Dispenser Therefor

Applicant/Assignee: SARA LEE

Application No.: 11/917486   Filing Date: 16/Jun/2005

Abstract:An antiperspirant system which includes a water-based antiperspirant which feels comfortable on the skin and a capillary aerosol dispenser is disclosed. The antiperspirant system includes: a pressurized container ( 51 ) in which a water-based antiperspirant composition with one or more astringent active salts and a propellant are present, a valved outlet ( 41 ) on the surface of the container through which antiperspirant is ejected into an inlet port ( 111 ) of a capillary tube ( 11 ), a capillary tube ( 11 ) with one inlet port ( 111 ) and one exit port through which antiperspirant is dispensed from the system, and a coupling means ( 12 ) to closely couple the inlet port of the capillary tube ( 11 ) to the valved outlet ( 41 ) of the pressurized container ( 51 ). The void volume between the inlet port and the valved outlet is minimized, such that upon use of the antiperspirant system, the valved outlet, the capillary tube, and the void volume do not become obstructed by solid deposits of the astringent active salt.

Priority: WO2005EP06467 Applic. Date: 2005-06-16

Inventor: CAMPBELL STUART JOHN [NL]; DE BEER ANDREW IWAN [NL]


Application No.: US20080112897A1  Published: 15/May/2008

Title: Product release system to atomize cosmetic hair or skin compositions containing UV filters

Applicant/Assignee:

Application No.: 11/471444   Filing Date: 20/Jun/2006

Abstract:A product release system for atomizing cosmetic hair or skin compositions is described, which has (a) pressure-resistant packaging, (b) a capillary-containing spray head, and (c) a propellant-containing cosmetic composition containing at least one UV filter. The atomization is done using the capillary. The capillary preferably has a diameter of 0.1 to 1 mm and a length of 5 to 100 mm. The spray rate is preferably 0.01 to 5 g/s. The composition can particularly be a gel, wax, or emulsion.

Priority: DE200510028388 Applic. Date: 2005-06-20

Inventor: SCHIEMANN HARTMUT [DE]; KRAUSE THOMAS [DE]; FRANZKE MICHAEL [DE]; WEBER DIRK [CH]; MOENKS MONIKA [CH]; BAUMEISTER JAN [CH]; FLORIG ELLEN [DE]


Application No.: US20080112904A1  Published: 15/May/2008

Title: Sunscreen Compositions And Methods Of Use

Applicant/Assignee:

Application No.: 11/740201   Filing Date: 25/Apr/2007

Abstract:The invention encompasses additives for addition to a bodywash, where the additives contain one or more sunscreens, and where a bodywash which contains the additive imparts to the skin an SPF of at least about 2, in some cases at least about 5, or 10, or 15. Also described are methods of making and using the additives.

Priority: US2006-350409 Applic. Date: 2006-02-07; US2005-076565 Applic. Date: 2005-03-08

Inventor: TRAYNOR DANIEL HENRY [US]; MARKOWITZ STEVEN M [US]; COMPTON DAVID L [US]; TRAYNOR HENRY G [US]; DULAK MICHAEL [US]


Application No.: US20080112906A1  Published: 15/May/2008

Title: Dispersible non-borate metal salt or chelate treated polygalactomannan polymers for use in personal care and household care applications

Applicant/Assignee:

Application No.: 11/982511   Filing Date: 02/Nov/2007

Abstract:The present invention relates to polygalactomannan compositions, and more particularly guar gum compositions, which, when crosslinked with organic chelating agents, such as non-borate metal salt or chelates, to form discrete guar particles which are capable of being easily dispersed in water which permits subsequent processing of the guar, such as washing. The guar and its derivatives are desirable for use in applications such as personal care and household care products.

Priority: US20060856486P Applic. Date: 2006-11-03

Inventor: ERAZO-MAJEWICZ PAQUITA [US]; KROON GIJSBERT [NL]; MAJEWICZ THOMAS G [US]


Application No.: US20080112907A1  Published: 15/May/2008

Title: Dispersible cationic polygalactomannan polymers for use in personal care and household care applications

Applicant/Assignee:

Application No.: 11/982591   Filing Date: 02/Nov/2007

Abstract:The present invention relates to polygalactomannan compositions, and more particularly cationic guar gum compositions, which, when crosslinked with glyoxal, from discrete guar particles which are capable of being easily dispersed in water which permits subsequent processing of the guar, such as washing. The guar and its derivatives are desirable for use in applications such as personal care, household care products and the like.

Priority: US20060856486P Applic. Date: 2006-11-03

Inventor: CHAN ANITA N [US]; ERAZO-MAJEWICZ PAQUITA [US]; KROON GIJSBERT [NL]; MAJEWICZ THOMAS G [US]


Application No.: US20080112909A1  Published: 15/May/2008

Title: COMPOSITIONS FOR PROVIDING COLOR TO ANIMATE OBJECTS AND RELATED METHODS

Applicant/Assignee: PPG INDUSTRIES OHIO, INC

Application No.: 12/017541   Filing Date: 22/Jan/2008

Abstract:Methods for providing color to animate objects, i.e., living things, as well as compositions, such as personal care compositions and agrochemical compositions, suitable for application to such animate objects. The compositions include colorants that include a radiation diffraction material comprising an ordered periodic array of particles held in a matrix, and/or a dispersion of polymer-enclosed nanoparticles.

Priority: US2006-337062 Applic. Date: 2006-01-20; US2004-876031 Applic. Date: 2004-06-24; US20070886142P Applic. Date: 2007-01-23; US20030482167P Applic. Date: 2003-06-24

Inventor: FALER DENNIS L [US]; MCCOLLUM GREGORY J [US]; MUNRO CALUM H [US]; POLK W D [US]


Application No.: US20080112915A1  Published: 15/May/2008

Title: Dna Delivery with Gemini Cationic Surfactants

Applicant/Assignee:

Application No.: 10/577025   Filing Date: 25/Oct/2004

Abstract:The invention provides a delivery system for a biologically active agent comprising a gemini surfactant in admixture with the biologically active agent in a topical formulation for treatment of skin disorders or metabolic diseases. The invention also provides pharmaceutical compositions in topical formulations comprising the delivery system as set out above, in admixture with pharmaceutically acceptable carriers, diluents, excipients, or supplements suitable for application to the skin or mucosal membrane. Methods of preparation and use are also described.

Priority: US20030514197P Applic. Date: 2003-10-24; WO2004CA01870 Applic. Date: 2004-10-25

Inventor: FOLDVARI MARIANNA [CA]; VERRALL RONALD E [CA]; BADEA ILDIKO [CA]


Application No.: US20080112960A1  Published: 15/May/2008

Title: MN/CA IX and EGFR Pathway Inhibition

Applicant/Assignee: INSTIUTE OF VIROLOGY OF THE SLOVAK ACADEMY OF SCIENCES

Application No.: 11/927150   Filing Date: 29/Oct/2007

Abstract:The invention is based upon the discovery that the EGFR pathway can stimulate a previously unknown tumorigenic function of CA IX, via phosphorylation of the sole tyrosine residue present in CA IX's intracellular domain. EGFR-phosphorylated CA IX then interacts with the p85 subunit of PI3K to activate Akt, which in turn is associated with anti-apototic function and increased cell survival. The latter finding indicates that there is a positive feedback loop for CA9 expression mediated by the PI3K pathway in preneoplastic/neoplastic diseases. Disclosed herein are novel therapeutic methods for treating preneoplastic/neoplastic diseases associated with abnormal MN/CA IX expression, using EGFR pathway inhibitors. Preferably, the EGFR pathway inhibitors are tyrosine kinase inhibitors or EGFR-specific antibodies.

Further disclosed are methods for patient therapy selection for EGFR pathway inhibitors, preferably in combination with other cancer therapies, based on detection of abnormal MN/CA9 gene expression in preneoplastic/neoplastic tissues.

Priority: US20060855507P Applic. Date: 2006-10-31

Inventor: DORAI THAMBI [US]


Application No.: US20080112991A1  Published: 15/May/2008

Title: METHOD OF ENHANCING SKIN ABSORPTION OF NUTRIENTS AND ACTIVE AGENTS

Applicant/Assignee: COTY B.V

Application No.: 12/016034   Filing Date: 17/Jan/2008

Abstract:The present invention relates to a cosmetic composition which contains electric carriers apart from specific active agents and auxiliaries. According to the present invention, the composition contains 0.1 to 10% by weight of a cosmetically acceptable, solid electret material with a particle size of 0.05 to 100 mum, which electret material is to be brought in the electrete state and has an induced permanent dipole moment and a permanent electric field with a field strength of 500 to 10<7 >Vm<-1>, as well as cosmetic carrier substances, auxiliaries, further active agents or a mixture thereof in an amount ranging up to 100% by weight.

Priority: DE20021057240 Applic. Date: 2002-12-04; US2003-725659 Applic. Date: 2003-12-02

Inventor: GOLZ-BERNER KARIN [MC]; WALZEL BERND [CH]; ZASTROW LEONHARD [MC]


Application No.: US20080113004A1  Published: 15/May/2008

Title: LOCAL ADMINISTRATION OF GALLIUM COMPOSITIONS TO TREAT PAIN

Applicant/Assignee:

Application No.: 11/936607   Filing Date: 07/Nov/2007

Abstract:Provided are methods of treating pain, including neuropathic pain, in human and veterinary individuals. These methods employ locally administrable pharmaceutical gallium compositions, including pharmaceutical gallium compositions suitable for administration to the skin and mucous membranes. The compositions comprise pharmaceutically acceptable gallium compounds, such as gallium maltolate or gallium nitrate, together with pharmaceutically acceptable carriers suitable for local administration, including those suitable for topical administration. The administration of such compositions provides relief from pain, itching, allodynia, hyperalgesia, and related symptoms.

Priority: US20060858182P Applic. Date: 2006-11-09

Inventor: BERNSTEIN LAWRENCE R [US]


Application No.: US20080113012A1  Published: 15/May/2008

Title: Method for using transdermal system with fentanyl

Applicant/Assignee: HEXAL AG

Application No.: 12/006879   Filing Date: 07/Jan/2008

Abstract:This invention relates to a transdermal system containing fentanyl as the active ingredient and consisting of or comprising a substrate, a mixture of the following ingredients applied to the substrate: the active ingredient, an oil-based aloe vera extract, a resin, and an adhesive, as well as a layer laminated to the mixture applied to the substrate.

Priority: DE20021009724 Applic. Date: 2002-03-06; US2003-379923 Applic. Date: 2003-03-05

Inventor: TISA-BOSTEDT KATALIN [DE]; FISCHER WILFRIED [DE]; LEICHS CHRISTIAN [DE]


Application No.: US20080113013A1  Published: 15/May/2008

Title: Transdermal, Therapeutic System With Activatable Oversaturation and Controlled Permeation Promotion

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEMS AG

Application No.: 11/793983   Filing Date: 08/Dec/2005

Abstract:A transdermal therapeutic system (TTS) that is essentially composed of two compartments and is provided with activatable oversaturation and controlled permeation promotion. The invention more particularly relates to a TTS wherein an oversaturated active ingredient solution is produced in an active-substance-containing polymer matrix when the system is applied to the skin, caused by the controlled supply of one or several substances promoting the permeation of the pharmaceutical active ingredient

to the two compartments from which the inventive transdermal therapeutic system is assembled

and to the production of the transdermal therapeutic system from the two compartments.

Priority: DE200410062614 Applic. Date: 2004-12-24; WO2005EP13133 Applic. Date: 2005-12-08

Inventor: KOCH ANDREAS [DE]


Application No.: US20080114017A1  Published: 15/May/2008

Title: Novel Indolopyridines, Benzofuranopyridines and Benzothienopyridines

Applicant/Assignee:

Application No.: 11/795763   Filing Date: 26/Jan/2006

Abstract:Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and X have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

Priority: EP20050100526 Applic. Date: 2005-01-27; WO2006EP50467 Applic. Date: 2006-01-26

Inventor: VENNEMANN MATTHIAS [DE]; BAR THOMAS [DE]; BRAUNGER JURGEN [DE]; GIMMNICH PETRA [DE]


Application No.: US20080114044A1  Published: 15/May/2008

Title: Compounds And Compositions As Ppar Modulators

Applicant/Assignee: IRM LLC

Application No.: 11/596596   Filing Date: 12/May/2005

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.

Priority: US20040571003P Applic. Date: 2004-05-14; WO2005US16672 Applic. Date: 2005-05-12

Inventor: EPPLE ROBERT [US]; RUSSO ROSS [US]; AZIMIOARA MIHAI [US]; XIE YONGPING [US]


Application No.: US20080114058A1  Published: 15/May/2008

Title: Use Of Lignan Compounds For Treating Or Preventing Inflammatory Disease

Applicant/Assignee:

Application No.: 11/813590   Filing Date: 06/Jan/2006

Abstract:The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a pharmaceutical composition for the treatment or prevention of an inflammatory disease, comprising a lignan compound represented by Formula I, as well as a treating method and the use of an inflammatory disease using the lignan compound. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX- 2 and TNF-alpha. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.

Priority: KR20050001761 Applic. Date: 2005-01-07; WO2006KR00065 Applic. Date: 2006-01-06

Inventor: HWANG JAE-KWAN [KR]; KIM DO-UN [KR]; CHUNG JAE-YOUN [KR]; CHUNG HEE-CHUL [KR]; HAN KYU-LEE [KR]


Application No.: US20080114281A1  Published: 15/May/2008

Title: Transdermal Delivery System for Polynucleotides

Applicant/Assignee: TRANSPHARMA MEDICAL LTD

Application No.: 10/597431   Filing Date: 25/Jan/2005

Abstract:The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

Priority: IL20040160033 Applic. Date: 2004-01-25; US20040626479P Applic. Date: 2004-11-10; WO2005IL00089 Applic. Date: 2005-01-25

Inventor: BIRCHALL JAMES [GB]; LEVIN GALIT [IL]; GERSHONOWITZ AMIKAM [IL]


Application No.: US20080115846A1  Published: 22/May/2008

Title: Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers

Applicant/Assignee: L'OREAL

Application No.: 11/653868   Filing Date: 17/Jan/2007

Abstract:Enhanced SPF and/or reduced fluffing fluid compositions for photoprotecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system capable of screening out UV radiation

and (b) at least one ester-terminated poly(ester amide) (ETPEA) polymer, formulated into (c) a topically applicable, cosmetically acceptable aqueous support therefor

the subject aqueous compositions are advantageously vaporizable, especially in the form of sprays, confined within a pressurization device.

Priority: FR20060050192 Applic. Date: 2006-01-19; US20060762127P Applic. Date: 2006-01-26

Inventor: JOSSO MARTIN [FR]; CHEVALIER CYRIL [FR]; GAUDRY ANNE-LAURE [FR]


Application No.: US20080118449A1  Published: 22/May/2008

Title: COSMETIC FORMULATIONS OF PICEATANNOL AND RETINOIDS AND METHODS OF USE THEREOF

Applicant/Assignee:

Application No.: 11/562250   Filing Date: 21/Nov/2006

Abstract:A cosmetic composition for skin care containing retinol and piceatannol is disclosed. In embodiments of the cosmetic composition piceatannol is preferably present in an amount of 0.001 to 10% by weight, and more preferably 0.1 to 1% by weight, based on the total weight of the composition. The piceatannol-containing cosmetic composition of the present invention alleviates adverse effects of retinol, such as skin irritation, and also enhances the skin care effect of retinol.

Priority:

Inventor: RONLAN ALVIN [US]


Application No.: US20080118458A1  Published: 22/May/2008

Title: Agent containing L-Carnitine or L-Carnitine derivatives and at least one other specific substance

Applicant/Assignee:

Application No.: 11/970187   Filing Date: 07/Jan/2008

Abstract:Compositions, in particular, for the treatment of the hair or of the skin, comprising at least one compound which is selected from L-carnitine or L-carnitine derivatives and at least one further substance which is selected from the group formed from active ingredients obtainable from the plants of the genus Echinacea, and also taurine and derivatives thereof.

Priority: DE200510031705 Applic. Date: 2005-07-05; WO2006EP06193 Applic. Date: 2006-06-27

Inventor: GIESEN MELANIE [DE]; SCHROEDER KLAUS RUDOLF [DE]; PETERSOHN DIRK [DE]


Application No.: US20080118463A1  Published: 22/May/2008

Title: Light Pharmaceutical Water and Therapeutic Compositions and Methods Thereof

Applicant/Assignee:

Application No.: 11/817930   Filing Date: 11/Mar/2005

Abstract:This invention relates to pharmaceutical water, which comprises from 99.760 to 99.999% of light isotopologue <1>H2 <16>O and up to 100% of residual isotopologues <1>H2 <17>O, <1>H2 <18>O, <1>H<2>H<16>O, <1>H<2>H<17>O, <1>H2H <18>O, <2>H2 <16>O, <2>H2 <17>O, and <2>H2 <18>O, for the production of finished product, intermediate reagent preparation, and analytical processes in pharmaceutical industry. Further, the invention relates to pharmaceutical compositions comprising a biologically active agent and said pharmaceutical water, wherein said agent is selected from the group consisting of drugs, physiologically active peptides, physiologically active proteins, and nucleic acids. Further, the invention relates to method of administering a biologically active agent to a mammal in need thereof, which method comprises a step of administering to said mammal said therapeutic composition.

Priority: WO2005RU00105 Applic. Date: 2005-03-11

Inventor: POMYTKIN IGOR ANATOLIEVICH [RU]; SOLOVIEV SERGEY PAVLOVICH [RU]


Application No.: US20080118537A1  Published: 22/May/2008

Title: Cosmetic composition containing hydrophilic spherical polymethylsilsesquioxane powder

Applicant/Assignee: GRANT INDUSTRIES, INC

Application No.: 11/603269   Filing Date: 21/Nov/2006

Abstract:A cosmetic composition is disclosed containing hydrophilic, spherical powder of polymethylsilsesquioxane having a particle size ranged from 1-20 microns with a narrow particle size distribution. The hydrophilic, spherical powder in the composition is prepared by a process comprising (1) hydrolyzing and condensing methyltrimethoxysilane in water in the presence of a thickener as suspending agent, an oil as surface tension modifier and an acid or base as catalyst to form spherical particles, (2) post-hydrolyzing the spherical particles in an aqueous NaOH solution and (3) purifying the spherical particles by repeated washing and vacuum stripping.

Priority:

Inventor: WANG JAMES J [US]; HUNG JIN L [US]


Application No.: US20080118557A1  Published: 22/May/2008

Title: SUSTAINED-RELEASE FORMULATIONS OF TOPIRAMATE

Applicant/Assignee: SUPERNUS PHARNACEUTICALS, INC

Application No.: 11/941475   Filing Date: 16/Nov/2007

Abstract:Pharmaceutical compositions of topiramate for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile. Method of treating or preventing pathological disorders in mammalian subjects comprising the administration of the novel formulations disclosed herein is also provided.

Priority: US20060859502P Applic. Date: 2006-11-17

Inventor: LIANG LIKAN [US]; WANG HUA [US]; BHATT PADMANABH P [US]; VIEIRA MICHAEL L [US]


Application No.: US20080118568A1  Published: 22/May/2008

Title: Benefit agent containing delivery particle

Applicant/Assignee:

Application No.: 11/986094   Filing Date: 20/Nov/2007

Abstract:The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, compositions for cleaning, fabric care, or coating onto various substrates, textiles or surfaces, such particles increase the efficiency of benefit agent delivery, thereby allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.

Priority: US20060861996P Applic. Date: 2006-11-30; US20060860645P Applic. Date: 2006-11-22

Inventor: SMETS JOHAN [BE]; SANDS PEGGY DOROTHY [US]; GUINEBRETIERE SANDRA JACQUELIN [US]; PINTENS AN [BE]; DIHORA JITEN ODHAVIJ [US]


Application No.: US20080118579A1  Published: 22/May/2008

Title: Medical Device and Its use

Applicant/Assignee: VIVOXID OY

Application No.: 11/666297   Filing Date: 02/Nov/2005

Abstract:The invention relates to a medical device comprising non-sintered bioactive glass particles or fibres having a diameter in the range 5-100 mum, bioactive glass comprising SiO2, Na2O, CaO, K2O, MgO, B2O3 and P2O5, wherein the amount of SiO2 is 50-65 wt-% of the final total weight, Na2O is 5-26 wt-% of the final total weight, CaO is 10-25 wt-% of the final total weight, K2O is 0-15 wt-% of the final total weight, MgO is 0-6 wt-% of the final total weight, B2O3 is 0-4 wt-% of the final total weight, and P2O5 is 0-4 wt-% of the final total weight, provided that the total amount of Na2O and K2O is 10-30 wt-% of the final total weight The device is essentially drug free. The invention also relates to the use of said composition for treating lesions associated with compromised or poor vascularisation and for preventing avascular fibrosis.

Priority: EP20040396075 Applic. Date: 2004-11-02; WO2005FI00468 Applic. Date: 2005-11-02

Inventor: JARVELAINEN HANNU [FI]; LAATO MATTI [FI]; SALONEN JUKKA [FI]; VEDEL ERIK [FI]


Application No.: US20080118591A1  Published: 22/May/2008

Title: Bactericidal Formulations

Applicant/Assignee:

Application No.: 11/719261   Filing Date: 15/Nov/2005

Abstract:The invention relates to bactericidal formulations that come into contact with human body, particularly wash formulations including liquid soaps, comprising perfume ingredients active against gram-negative bacteria. Such compositions contact the target site, for example the skin surface, only for a short time, usually not longer than 30 seconds. Therefore the antibacterial action has to be of the bactericidal type and rapid. Furthermore, the bactericidal activity has to be sufficiently high to ensure an effect even when applied to wet substrates that will dilute the bactericidal formulation.

Priority: GB20040025305 Applic. Date: 2004-11-17; WO2005CH00676 Applic. Date: 2005-11-15

Inventor: NATSCH ANDREAS [CH]


Application No.: US20080118734A1  Published: 22/May/2008

Title: Coating Compositions

Applicant/Assignee: DOW CORNING IRELAND LTD

Application No.: 11/569100   Filing Date: 13/May/2005

Abstract:A method for forming an active material containing coating on a substrate, which method comprises the steps of: i) introducing one or more gaseous or atomised liquid and/or solid coating-forming materials which undergo chemical bond forming reactions within a plasma environment and one or more active materials which substantially do not undergo chemical bond forming reactions within a plasma environment, into an atmospheric or low pressure non-thermal equilibrium plasma discharge and/or an excited gas stream resulting therefrom, and ii) exposing the substrate to the resulting mixture of atomised coating-forming and at least one active material which are deposited onto the substrate surface to form a coating

wherein the substrate is not a wipe, cloth or sponge for household care or depilatory care or a water solute household cleaning unit dose product.

Priority: GB20040010749 Applic. Date: 2004-05-14; WO2005GB01828 Applic. Date: 2005-05-13

Inventor: GOODWIN ANDREW JAMES [IE]; LEADLEY STUART ROBERT [IE]; O'NEILL LIAM [IE]; DUFFIELD PAUL JOHN [GB]; MCKECHNIE MALCOLM TOM [GB]; PUGH SIMON [GB]


Application No.: US20080119492A1  Published: 22/May/2008

Title: Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation

Applicant/Assignee:

Application No.: 11/374312   Filing Date: 28/Jul/2006

Abstract:The present invention relates to compositions and methods for treating cancer and other disease states characterized by abnormal cell proliferation. In particular, the present invention relates to certain novel non-nucleoside pharmacologically active compounds that alter telomere and telomerase functions, regulate cell proliferation and/or treat cancer and other diseases characterized by abnormal cell proliferation. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, and to treat cancer or to inhibit the proliferation of the rumor cells, and to treat other proliferative conditions.

Priority: US20050704184P Applic. Date: 2005-07-29

Inventor: LEHN JEAN-MARIE [FR]; MERGNY JEAN-LOUIS [FR]; PETITJEAN ANNE [CA]; TEULADE-FICHOU MAIA-PAULE [FR]; TCHIRKOV ANDREI [FR]; VERRELLE PIERRE [FR]


Application No.: US20080119504A1  Published: 22/May/2008

Title: NEW APORPHINE ESTERS AND THEIR USE IN THERAPY

Applicant/Assignee: AXON BIOCHEMICALS B.V

Application No.: 12/021560   Filing Date: 29/Jan/2008

Abstract:New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivates are also disclosed.

Priority: WO2001SE01658 Applic. Date: 2001-07-20; US2003-344420 Applic. Date: 2003-07-15; US2005-061881 Applic. Date: 2005-02-22; SE20000002934 Applic. Date: 2000-08-17

Inventor: WIKSTROM HAKAN [NL]; DIJKSTRA DURK [NL]; CREMERS THOMAS [NL]; ANDREN PER E [SE]; MARCHAIS SANDRINE [NL]; JURVA ULRIK [NL]


Application No.: US20080119527A1  Published: 22/May/2008

Title: Composition for combating the localized hyperpigmentation of dark skin

Applicant/Assignee: L'OREAL

Application No.: 11/898426   Filing Date: 12/Sep/2007

Abstract:The present invention relates to a composition comprising, in a physiologically acceptable medium, at least one copolymer of a styrene monomer and of an ethylenically unsaturated dicarboxylic acid and at least one anti-seborrhoeic active agent.

Priority: FR20060053752 Applic. Date: 2006-09-15; US20060847918P Applic. Date: 2006-09-29

Inventor: BALDO FRANCINE [FR]


Application No.: US20080119546A1  Published: 22/May/2008

Title: TREATMENT OF HYPERPROLIFERATIVE CONDITIONS OF BODY SURFACES

Applicant/Assignee:

Application No.: 12/020852   Filing Date: 28/Jan/2008

Abstract:The present invention relates to pharmaceutical formulations comprising an anthracycline and the uses thereof for treatment of clinical conditions of body surfaces such as skin and mucosal membranes, wherein abnormal cell differentiation and/or hyperproliferation is a primary factor of the pathogenesis. In particular the invention relates to treatment of psoriasis, and preferably to treatment of psoriasis with valrubicin topically applied.

Priority: DK20010001218 Applic. Date: 2001-08-14; US2004-486648 Applic. Date: 2004-07-23; WO2002DK00530 Applic. Date: 2002-08-12

Inventor: BYMOSE BJARNE [DK]; CHRISTENSEN THOMAS BROE [DK]


Application No.: US20080119558A1  Published: 22/May/2008

Title: Drug for Inhibiting Production of Matrix Metalloprotease-9

Applicant/Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Application No.: 10/535672   Filing Date: 08/Oct/2003

Abstract:A drug for inhibiting the production of matrix metalloproteinase-9 which contains leptomycin B or its derivative as the active ingredient can specifically inhibit the production of MMP-9 compared with MMP-2, furthermore, has an effect of inhibiting the production of MMP-9 even under stimulating the differentiation by adding calcium at a high concentration or adding TGF-beta, and under stimulating for inducing inflammation by adding TNF-alpha or adding IL-2alpha.

Priority: JP20020336867 Applic. Date: 2002-11-20; JP20030286386 Applic. Date: 2003-08-05; JP20030136738 Applic. Date: 2003-05-15; WO2003JP12898 Applic. Date: 2003-10-08

Inventor: KOBAYASHI TAKASHI [JP]


Application No.: US20080124282A1  Published: 29/May/2008

Title: Oil-containing deodorizing aerosol compositions having skin-cooling active substances

Applicant/Assignee:

Application No.: 11/948192   Filing Date: 30/Nov/2007

Abstract:Essentially alcohol-free deodorizing aerosol compositions which contain selected oils, a skin-cooling active substance, a deodorizing active substance and a propellant gas.

Priority: DE200510025495 Applic. Date: 2005-06-01; WO2006EP04931 Applic. Date: 2006-05-24

Inventor: EMMERLING WINFRIED [DE]; HEINSOHN ULRIKE [DE]


Application No.: US20080124287A1  Published: 29/May/2008

Title: Cosmetic composition having whitening effect comprising extract of pulsatilla radix as main ingredient

Applicant/Assignee:

Application No.: 11/898896   Filing Date: 17/Sep/2007

Abstract:Disclosed is whitening cosmetic composition comprising extract of Pulsatillae Radix as main ingredient if necessary, additionally comprising ingredient(s) selected from the group consisting of ranunculin, deoxypodophyllotoxin and 3-O-alpha-L-ramnopyranosyl(1->2)-[beta-D-glucopyranosyl(1-4)]-alpha-L-arabinopyranoside(SB 365 ) obtained from the extract of Pulsatillae Radix and auxiliary ingredient(s) selected from the group consisting extract of Ulmaceae Cortex and extract of Glycyrrhizae Radix. The present composition has an excellent whitening effect.

Priority: KR20020057653 Applic. Date: 2002-09-23; US2005-086919 Applic. Date: 2005-03-23; WO2003KR01905 Applic. Date: 2003-09-18

Inventor: KIM JONG SEOK [KR]; KIM HYE YOUNG [KR]; KIM JONG UK [KR]


Application No.: US20080124297A1  Published: 29/May/2008

Title: Method for reducing allergencity in indoor spaces

Applicant/Assignee: MEDACHIEVE, INC

Application No.: 11/979239   Filing Date: 31/Oct/2007

Abstract:According to this invention, allergenicity in an indoor space is reduced by denaturing allergens in allergen reservoirs that are capable of producing respiratory or skin reactions and physically removing the allergens from the allergen reservoirs in the indoor space. The allergen reservoirs may also be treated with pesticides and fungicides/fungistats to prevent reinfestation of house dust mites, molds and cockroaches.

Priority: US2006-529586 Applic. Date: 2006-09-29; US2005-239473 Applic. Date: 2005-09-30; US2002-153612 Applic. Date: 2002-05-24; US20010293183P Applic. Date: 2001-05-25

Inventor: PAYTON HUGH W [US]


Application No.: US20080124303A1  Published: 29/May/2008

Title: Methods and compositions for treatment of viral infections

Applicant/Assignee: CAVIT SCIENCES, INC

Application No.: 11/827491   Filing Date: 12/Jul/2007

Abstract:A novel method of treating and preventing viral diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of viral infections and the diseases associated with such viral infections. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made compositions comprising a substance exhibiting Tubercin and/or SSM activity or a functional derivative thereof.

Priority: US2005-298629 Applic. Date: 2005-12-12

Inventor: KING COLM [US]


Application No.: US20080124312A1  Published: 29/May/2008

Title: Polyamine Compositions

Applicant/Assignee:

Application No.: 11/666937   Filing Date: 07/Nov/2005

Abstract:The present invention provides a method of inhibiting formation of solid hydrates in a conduit used to contain a flowing, water-containing hydrocarbon, which method comprises introducing into said hydrocarbon in said conduit a gas which raises the pressure threshold for hydrate formation for said water-containing hydrocarbon, said gas being introduced in a manner which causes it to travel along at least part of said conduit in the direction of hydrocarbon flow.

Priority: NO20040004818 Applic. Date: 2004-11-05; WO2005GB04279 Applic. Date: 2005-11-07

Inventor: LOVAAS ERIK [NO]


Application No.: US20080124344A1  Published: 29/May/2008

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC

Application No.: 11/814549   Filing Date: 18/Jul/2006

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20050708312P Applic. Date: 2005-08-15; WO2006US27777 Applic. Date: 2006-07-18

Inventor: COMBS KATHERIN E [US]; CULBERTSON LING LING [US]; DELMAS-MATA JUAN [US]; DE SAUVAGE FREDERIC [US]; FAN LIANGFEN [US]; FRANTZ GRETCHEN [US]; GREEN LESLIE JANE [US]; MASSEY ERIN MARIE [US]; MCLAIN DINA REBECCA [US]; MONTGOMERY CHARLES [US]; PAYNE BOBBY JOE [US]; PEALE FRANKLIN [US]; PHILLIPS HEIDI [US]; ROHRER MICHELLE [US]; SEVAUX TRACY E W [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; STALA JOY ANNE [US]; TANG TRACY TZU-LING [US]; WANG CHING-YUN [US]; XIONG WEN [US]; VOGEL PETER [US]


Application No.: US20080124402A1  Published: 29/May/2008

Title: N-(Pyridin-3-Yl)-2-Phenylbutanamides As Androgen Receptor Modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 11/666525   Filing Date: 25/Oct/2005

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20040623442P Applic. Date: 2004-10-29; WO2005US39931 Applic. Date: 2005-10-25

Inventor: KIM YUNTAE [US]; CLOSE JOSHUA [US]; DUGGAN MARK E [US]; HANNEY BARBARA [US]; MEISSNER ROBERT S [US]; MUSSELMAN JEFFREY [US]; PERKINS JAMES J [US]; WANG JIABING [US]


Application No.: US20080124504A1  Published: 29/May/2008

Title: Durable honeycomb structures

Applicant/Assignee:

Application No.: 11/605632   Filing Date: 29/Nov/2006

Abstract:A method for manufacturing an inorganic honeycomb structure that resists water damage after drying comprises compounding a base batch mixture including inorganic powders, a batch cross-link agent, an aqueous vehicle, and a cross-linkable batch constituent, and forming the batch mixture into a honeycomb core or skin component while reacting the cross-link agent with cross-linkable batch constituent.

Priority:

Inventor: FABER MARGARET KATHLEEN [US]; LAWRENCE ROBERT GORDON [US]; MIAO WEIGUO [US]; WANG JIANGUO [US]


Application No.: US20080124766A1  Published: 29/May/2008

Title: Scaffold Material Capable of Inducing Biological Hard Tissue or Soft Tissue

Applicant/Assignee:

Application No.: 11/663729   Filing Date: 26/Sep/2005

Abstract:To provide an implant material which exhibits relatively high mechanical binding with an osteoblast and also high strength. [MEANS FOR SOLVING PROBLEMS] A scaffold material ( 10 ) capable of inducing a biological hard tissue, which comprises a rod ( 11 ) having a trunk portion ( 21 ) and bride girders ( 22 ), a binding layer ( 13 ) formed on the periphery of the rod and a metal fiber layer ( 14 ) formed on the periphery of the binding layer, and which further has a reinforcing layer ( 15 ) formed on the periphery of the metal fiber layer ( 14 ). The binding layer ( 13 ) has pores having an average pore size of less than 100 m, and the metal fiber layer ( 14 ) has pores having an average pore size of 100 to 400 m.

Priority: JP20040278152 Applic. Date: 2004-09-24; JP20040279979 Applic. Date: 2004-09-27; WO2005JP17655 Applic. Date: 2005-09-26

Inventor: KUBOKI YOSHINORI [JP]; SEKI YASUO [JP]; SHIOTA HIROYUKI [JP]


Application No.: US20080125399A1  Published: 29/May/2008

Title: 17 Beta-Acetamide-4-Azasteroids As Androgen Receptor Modulators

Applicant/Assignee:

Application No.: 10/594853   Filing Date: 04/Apr/2005

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20040560385P Applic. Date: 2004-04-08; WO2005US11537 Applic. Date: 2005-04-04

Inventor: WANG JIABING [US]; MCVEAN CAROL A [US]


Application No.: US20080125408A1  Published: 29/May/2008

Title: PENEM PRODRUG

Applicant/Assignee: PFIZER INC

Application No.: 11/938942   Filing Date: 13/Nov/2007

Abstract:The invention relates to prodrugs of sulopenem of formula (I): wherein R<1 >is -(C2-C8)alkyl, or a solvate or hydrate thereof. The invention also relates to the preparation, formulation, and use of the prodrugs of sulopenem to treat a disorder such as an infection in a patient in need thereof.

Priority: US20070978816P Applic. Date: 2007-10-10; US20060865669P Applic. Date: 2006-11-14

Inventor: BRIGHTY KATHERINE ELIZABETH [US]; MARFAT ANTHONY [US]; MCLEOD DALE GORDON [US]; O'DONNELL JOHN P [US]; ANDERSON STEPHEN R [US]


Application No.: US20080125437A1  Published: 29/May/2008

Title: MAPK/ERK KINASE INHIBITORS

Applicant/Assignee: TAKEDA SAN DIEGO, INC

Application No.: 11/876635   Filing Date: 22/Oct/2007

Abstract:Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Priority: US20060862569P Applic. Date: 2006-10-23

Inventor: DONG QING [US]; FEHER VICTORIA [US]; KALDOR STEPHEN W [US]; TOMITA NAOKI [JP]


Application No.: US20080125452A1  Published: 29/May/2008

Title: Indolopyridines,Benzofuranopyridines and Benzothienopyridines

Applicant/Assignee: ALTANA PHARMA AG

Application No.: 11/795762   Filing Date: 26/Jan/2006

Abstract:Compounds of a certain formula (I), in which R1, R2, R3, R4, R5 and X have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

Priority: EP20050100594 Applic. Date: 2005-01-28; EP20050100913 Applic. Date: 2005-02-09; WO2006EP50465 Applic. Date: 2006-01-26

Inventor: VENNEMANN MATTHIAS [DE]; BAR THOMAS [DE]; BRAUNGER JURGEN [DE]; GIMMNICH PETRA [DE]; BECKERS THOMAS [DE]; SCHMIDT MATHIAS [DE]; CIOSSEK THOMAS [DE]; NAPPE SANDRA [DE]


Application No.: US20080131386A1  Published: 05/Jun/2008

Title: Topical product formulations containing strontium for reducing skin irritation

Applicant/Assignee: COSMEDERM TECHNOLOGIES, INC

Application No.: 11/979154   Filing Date: 31/Oct/2007

Abstract:Topical formulations containing aqueous-soluble divalent strontium cation in a suitable topical formulation vehicle, and methods of using these formulations to inhibit skin irritation, are disclosed.

Priority: US2001-992491 Applic. Date: 2001-11-21; US2001-871576 Applic. Date: 2001-05-31; US1998-149886 Applic. Date: 1998-09-08; US1996-666978 Applic. Date: 1996-06-20; US1994-362100 Applic. Date: 1994-12-21

Inventor: HAHN GARY S [US]; THUESON DAVID O [US]


Application No.: US20080131437A1  Published: 05/Jun/2008

Title: Use Of Soluble Cd164 Variants In Inflammatory And/Or Autoimmune Disorders

Applicant/Assignee: LABORATOIRES SERONA S.A MERCK SERONO S.A

Application No.: 11/814389   Filing Date: 24/Jan/2006

Abstract:The present invention relates to sCD164 variants and therapeutic uses thereof, in particular for treating or preventing inflammatory or autoimmune disorders.

Priority: EP20050100432 Applic. Date: 2005-01-24; US20050655382P Applic. Date: 2005-02-23; WO2006EP50422 Applic. Date: 2006-01-24

Inventor: SABORIO GABRIELA [FR]; POWER CHRISTINE [FR]; PROUDFOOT AMANDA [FR]


Application No.: US20080131501A1  Published: 05/Jun/2008

Title: Enhanced immediate release formulations of topiramate

Applicant/Assignee: SUPERNUS PHARMACEUTICALS, INC

Application No.: 11/987806   Filing Date: 04/Dec/2007

Abstract:The present invention provides enhanced immediate release formulations of topiramate, in which 80% of the active ingredient is released in the period of time of not more than 30 min. These formulations may be advantageously used for the treatment of acute neurological conditions, such as migraine.

Priority: US20060872497P Applic. Date: 2006-12-04

Inventor: LIANG LIKAN [US]; BHATT PADMANABH P [US]; WANG HUA [US]


Application No.: US20080138296A1  Published: 12/Jun/2008

Title: Foam prepared from nanoemulsions and uses

Applicant/Assignee: FOAMIX LTD

Application No.: 11/975621   Filing Date: 19/Oct/2007

Abstract:The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water nano emulsion composition includes: (a) a nano oil globule system, comprising substantially of sub-micron oil globules

(b) about 0.1% to about 5% by weight of at least one stabilizing agent, selected from the group consisting of (i) a non-ionic surfactant, (ii) an ionic surfactant, and (iii) a polymeric agent

and (c) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration. The present invention further provides methods of treating, alleviating or preventing a disorder of the skin, body cavity or mucosal surface using such foamable compositions

and to methods of producing such foams having an improved bubble size.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2006-389742 Applic. Date: 2006-03-27; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20050717058P Applic. Date: 2005-09-14; US20020429546P Applic. Date: 2002-11-29

Inventor: TAMARKIN DOV [IL]; BESONOV ALEX [IL]; EINI MEIR [IL]; DANZIGER JORGE [IL]


Application No.: US20080138302A1  Published: 12/Jun/2008

Title: Cosmetic composition comprising at least one volatile ester

Applicant/Assignee:

Application No.: 11/984725   Filing Date: 21/Nov/2007

Abstract:The present application relates to a cosmetic composition comprising at least one ester corresponding to formula (I) below: R1COOR2 (I) in which R1 represents H or a linear or branched hydrocarbon-based radical, and R2 represents a linear or branched hydrocarbon-based radical, with the proviso that: when R2 is a linear hydrocarbon-based radical and R1 is H or a linear hydrocarbon-based radical, then 7<=R1+R2<=8

and when at least one of R1 and R2 is a branched hydrocarbon-based radical, then 8<=R1+R2<=10, with the proviso that, when R1 is tert-butyl, then R2 is not isohexyl. This composition can be used as a product for caring for and/or making up keratin materials, in particular the skin, the lips and/or the integuments.

Priority: FR20060055073 Applic. Date: 2006-11-23; US20060872777P Applic. Date: 2006-12-05

Inventor: AUGUSTE FREDERIC [FR]; FOURON JEAN-YVES [FR]


Application No.: US20080138303A1  Published: 12/Jun/2008

Title: Photoprotective cosmetic compositions comprising silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups and non-silicon-containing lipophilic triazine compound UV-screening agents

Applicant/Assignee: L'OREAL

Application No.: 11/987213   Filing Date: 28/Nov/2007

Abstract:UV-photoprotective, topically applicable cosmetic/dermatological compositions contain: (a) at least one silicon-containing s-triazine substituted with two aminobenzoate or aminobenzamide groups of specific formula (I), and (b) at least one non-silicon-containing lipophilic 1,3,5-triazine compound UV-screening agent, such compositions having improved photoprotective effectiveness in the UV-B range and the 1,3,5-triazine compound(s) being improvedly soluble therein.

Priority: FR20060055166 Applic. Date: 2006-11-28; US20060873564P Applic. Date: 2006-12-08

Inventor: CANDAU DIDIER [FR]; RICHARD HERVE [FR]


Application No.: US20080138379A1  Published: 12/Jun/2008

Title: Methods, treatments, and compositions for modulating Hedgehog pathways

Applicant/Assignee:

Application No.: 12/001869   Filing Date: 13/Dec/2007

Abstract:The present invention relates to prevention of congenital deformations The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events gene expression during prenatal development, post-natal development and during development in the adult organism.

Priority: US2006-591398 Applic. Date: 2006-11-01

Inventor: JENNINGS-SPRING BARBARA L [US]


Application No.: US20080138386A1  Published: 12/Jun/2008

Title: Crosslinkable Saccharide-Siloxane Compositions, and Networks, Coatings and Articles Formed Therefrom

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 11/793067   Filing Date: 22/Dec/2005

Abstract:The invention provides a cross-linkable composition comprising a saccharide-siloxane copolymer according to a specified structural formula, a crosslinking agent, and, optionally, solvent. Cross-linked polymeric networks, cured coatings, and articles of manufacture formed from the inventive compositions are also provided, as well as processes and methods of manufacturing the inventive cross-linkable compositions and applications thereof.

Priority: US20040638871P Applic. Date: 2004-12-23; WO2005US46780 Applic. Date: 2005-12-22

Inventor: JOFFRE ERIC JUDE [US]; MCAULIFFE JOSEPH C [US]; KOLLAR CSILLA [US]; THOMAS XAVIER [FR]; GANTNER DAVID C [US]


Application No.: US20080138390A1  Published: 12/Jun/2008

Title: Transdermal Delivery System For Use With Basic Permeation Enhancers

Applicant/Assignee:

Application No.: 11/547987   Filing Date: 07/Apr/2005

Abstract:The present invention includes transdermal delivery systems having a polymeric active agent reservoir fabricated from an admixture of polyisobutylene and an insoluble hydrophilic polymer in powdered form, which provide numerous advantages in the transdermal delivery of active agents using basic enhancer compositions. For example, the systems of the invention provide for (1) increased permeation of the active agent through the skin, (2) an improved capability of extracting the active agent and enhancer from the transdermal systems, (3) enhanced structural integrity, (4) good chemical stability, (5) reduced phase separation, and (6) decreased cold flow.

Priority: US20040560499P Applic. Date: 2004-04-07; WO2005US12163 Applic. Date: 2005-04-07

Inventor: HSU TSUNG-MIN [US]; JACOBSON ERIC C [US]; LUO ERIC C [US]; HICKEY ALAN T J [US]; GRICENKO NICOLE T [US]


Application No.: US20080138420A1  Published: 12/Jun/2008

Title: Microencapsulation Product and Process

Applicant/Assignee:

Application No.: 11/792727   Filing Date: 07/Dec/2005

Abstract:Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-diethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.

Priority: US20040634219P Applic. Date: 2004-12-08; WO2005US44222 Applic. Date: 2005-12-07

Inventor: SPEAKER TYCHO J [US]


Application No.: US20080138913A1  Published: 12/Jun/2008

Title: Composition for Prevention, Treatment, and Diagnosis of Chronic Inflammatory Airway Diseases

Applicant/Assignee:

Application No.: 11/722712   Filing Date: 02/Jan/2006

Abstract:A pharmaceutical composition for preventing or treating chronic inflammatory airway diseases comprising alpha-enolase protein as an active ingredient is provided. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing chronic inflammatory airway diseases comprising alpha-enolase protein. The present invention further provides a composition for screening a therapeutic agent for chronic inflammatory airway diseases, comprising one or more of alpha-enolase protein or autoantibodies to alpha-enolase obtained from patients with chronic inflammatory airway diseases, and a method for screening a therapeutic agent for chronic inflammatory airway diseases using this composition. The present invention still further provides methods for diagnosing, preventing or treating chronic inflammatory airway diseases using alpha-enolase protein.

Priority: KR20050000098 Applic. Date: 2005-01-03; KR20050013584 Applic. Date: 2005-02-18; KR20050135454 Applic. Date: 2005-12-30; WO2006KR00005 Applic. Date: 2006-01-02

Inventor: JEON SOOK-YEONG [KR]; NAHM DONG-HO [KR]


Application No.: US20080139432A1  Published: 12/Jun/2008

Title: Personal care composition containing a non-guar galactomannan polymer derivative and an anionic surfactant system

Applicant/Assignee:

Application No.: 11/264497   Filing Date: 01/Nov/2005

Abstract:Personal care compositions comprise (a) from about 0.01 wt. % to about 10 wt. % of a galactomannan polymer derivative having a mannose to galactose ratio of greater than 2:1 on a monomer to monomer basis, the galactomannan polymer derivative selected from a cationic galactomannan polymer derivative and an amphoteric galactomannan polymer derivative having a net positive charge, wherein the cationic galactomannan polymer has a molecular weight from about 1,000 to about 10,000,000 and a cationic charge density from about 0.7 meq/g to about 7 meq/g

(b) from about 5 wt. % to about 35 wt. % of an anionic surfactant system, the anionic surfactant system comprising at least one anionic surfactant and having an ethoxylate level and an anion level, (i) wherein the ethoxylate level is from about 1 to about 6, and (ii) wherein the anion level is from about 1.5 to about 6

and (c) an aqueous carrier. Personal care compositions as described above further comprise from about 0.01 wt. % to about 10 wt. % of one or more conditioning agents. Methods of treating hair or skin comprise applying the personal care compositions as described above to the hair or skin and rinsing the hair or skin.

Priority: US20040625633P Applic. Date: 2004-11-05

Inventor: PEFFLY MARJORIE MOSSMAN [US]; STAUDIGEL JAMES ANTHONY [US]; PLIEGO SALVADOR [US]; DECKNER GEORGE ENDEL [US]


Application No.: US20080139453A1  Published: 12/Jun/2008

Title: Multiple emulsion compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/001526   Filing Date: 12/Dec/2007

Abstract:The present invention relates to an O/W/O emulsion comprising

a) an external oil phase which comprises an emulsifying crosslinked siloxane elastomer and a solvent for the emulsifying crosslinked siloxane elastomer

and b) an O/W type primary emulsion which comprises an internal oil phase dispersed in an aqueous phase dispersed in the external oil phase wherein the aqueous phase comprises from about 0.01% to about 10% of a hydrophobically modified polymeric emulsifier, wherein when shear stress is applied to the O/W/O emulsion during spreading on skin, at least a portion of the primary emulsion is released from the O/W/O emulsion. The present invention also relates to an O/W/O emulsion composition comprising: a) from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer

b) from about 0.01% to about 10% of a hydrophobically modified polymeric emulsifier

c) from about 1% to about 40% of a solvent for the emulsifying crosslinked siloxane elastomer

and d) water, wherein when shear stress is applied to the composition during spreading on skin, phase separation is occurred.

Priority: US20060874533P Applic. Date: 2006-12-12

Inventor: YOSHIMI NAOHISA [JP]; TANAKA HIDEKAZU [JP]


Application No.: US20080139457A1  Published: 12/Jun/2008

Title: Therapeutic compositions comprising chorionic gonadotropins and HMG CoA reductase inhibitors

Applicant/Assignee: VIRGINIA COMMONWEALTH UNIVERSITY

Application No.: 11/521213   Filing Date: 14/Sep/2006

Abstract:The invention provides improved methods and compositions for the treatment of cancer in a subject comprising administering to said subject a therapeutically effective amount of a composition comprising a chorionic gonadotropin or a therapeutically active fragment or analogue thereof in combination with an HMG CoA reductase inhibitor. The compositions and methods may also comprise geranylgeranyltransferase inhibitors (GGTI) and farnesyltransferase inhibitors (FTI) instead of or in addition to the HMG CoA reductase inhibitors of the invention.

Priority: US20050717205P Applic. Date: 2005-09-16

Inventor: DENT PAUL [US]


Application No.: US20080139488A1  Published: 12/Jun/2008

Title: Compositions comprising avermectin/azelaic acid compounds useful for treating, e.g., rosacea

Applicant/Assignee: GALDERMA S.A

Application No.: 11/898911   Filing Date: 17/Sep/2007

Abstract:Pharmaceutical/dermatological compositions useful for the prevention/treatment of disorders of the skin, especially rosacea, contain thus effective amounts of at least one avermectin compound, e.g., ivermectin, and at least one azelaic acid compound or salt or derivative thereof, formulated into a physiologically acceptable medium therefor.

Priority: FR20050002645 Applic. Date: 2005-03-17; WO2006FR00570 Applic. Date: 2006-03-15

Inventor: KAOUKHOV ALEXANDRE [FR]; PERNIN COLETTE [FR]


Application No.: US20080139513A1  Published: 12/Jun/2008

Title: TRANSDERMAL DELIVER OF ACTIVE AGENTS

Applicant/Assignee: NOVAVAX, INC

Application No.: 11/862150   Filing Date: 26/Sep/2007

Abstract:A composition for transdermal delivery of a non-traditional active agent is described. The compositions comprise: (a) a non-traditional transdermal active agent

(b) a solvent

(c) a non-miscible liquid

(d) a stabilizer

and (e) water, wherein the composition is formulated into an emulsion.

Priority: US20060847092P Applic. Date: 2006-09-26

Inventor: LEE ROBERT [US]; SHENOY DINESH [US]; BANDAK STEVE [US]


Application No.: US20080139630A1  Published: 12/Jun/2008

Title: N-(2-Benzyl)-2-Phenylbutanamides As Androgen Receptor Modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 11/628685   Filing Date: 03/Jun/2005

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies,

cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20040577698P Applic. Date: 2004-06-07; WO2005US19554 Applic. Date: 2005-06-03

Inventor: HANNEY BARBARA [US]; KIM YUNTAE [US]; KROUT MICHAEL R [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]; MUSSELMAN JEFFREY [US]; PERKINS JAMES J [US]; WANG JIABING [US]


Application No.: US20080143214A1  Published: 19/Jun/2008

Title: SELF-CONTAINED VOLTAGE GENERATING SYSTEMS

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/958633   Filing Date: 18/Dec/2007

Abstract:A self-contained voltage generating system is incorporated in a package or device for housing a product. There is at least one piezoelectric element incorporated in the package or device and the piezoelectric element generates a source of voltage when it is activated. The voltage is then used to perform various activities on other elements that are part of the package or device, such as operate a motor, provide heat, provide ultrasonic energy, furnish light, provide acoustic energy, and provide vibration energy. The piezoelectric elements are in the form of discrete particles, piezoelectric fibers, filaments, transducers, and actuators.

Priority: US20060875467P Applic. Date: 2006-12-18

Inventor: MCNAMARA WILLIAM E [US]; KUREK JOHN S [US]; LAMBERTY LISA [US]; VOGEL RONALD F [US]; GONZALEZ ANTHONY D [US]; CERUTTI DAVID [US]; ORNOSKI GREGORY A [US]


Application No.: US20080145324A1  Published: 19/Jun/2008

Title: UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups

Applicant/Assignee: L'OREAL

Application No.: 11/998421   Filing Date: 30/Nov/2007

Abstract:UV-photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane UV-sunscreen compound and at least one photostabilizing silicon-containing s-triazine compound substituted with two aminobenzoate or aminobenzamide groups.

Priority: FR20050051434 Applic. Date: 2005-05-31; WO2006EP05333 Applic. Date: 2006-05-15; US20050697969P Applic. Date: 2005-07-12

Inventor: RICHARD HERVE [FR]; CANDAU DIDIER [FR]


Application No.: US20080145330A1  Published: 19/Jun/2008

Title: AGENT FOR INHIBITING THE GROWTH OF MAMMALIAN HAIR

Applicant/Assignee:

Application No.: 11/957459   Filing Date: 16/Dec/2007

Abstract:The present invention comprises of a composition for post-hair-removal topical application for inhibiting mammalian hair growth & application thereof. The present invention also embraces a method of inhibiting mammalian hair growth by applying an effective amount of the composition to the skin. The composition comprises of a hair growth-inhibiting agent and a dermatologically acceptable vehicle.

Priority: IN2004MU00873 Applic. Date: 2004-08-13; US2004-988804 Applic. Date: 2004-11-15

Inventor: KONDHALKAR MRINMAYEE BHUSHAN [IN]


Application No.: US20080145331A1  Published: 19/Jun/2008

Title: COMPOSITONS AND MEHTODS OF INDUCING HAIR GROWTH UTILIZING CONTINUS COGGYGRIA

Applicant/Assignee: J&J CONSUMER COMPANIES, INC

Application No.: 11/952399   Filing Date: 07/Dec/2007

Abstract:This application relates to compositions and methods for inducing hair growth and improving hair quality utilizing extracts of Cotinus coggygria in an amount effective to induce hair growth when applied topically to an area of the skin on which hair growth is desired.

Priority: US20060869770P Applic. Date: 2006-12-13

Inventor: BRUNING ELIZABETH [US]; STONE VIOLETTA IOTSOVA [US]; ZHAO RENBIN [US]


Application No.: US20080145336A1  Published: 19/Jun/2008

Title: Isoindoline compounds and methods of their use

Applicant/Assignee: CELGENE CORPORATION

Application No.: 12/070322   Filing Date: 15/Feb/2008

Abstract:Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclosed.

Priority: US2004-900332 Applic. Date: 2004-07-28

Inventor: MULLER GEORGE W [US]; MAN HON-WAH [US]


Application No.: US20080145388A1  Published: 19/Jun/2008

Title: Product for the Targeted Release of Two-Compartment Active Substances

Applicant/Assignee:

Application No.: 11/886352   Filing Date: 16/Feb/2006

Abstract:The invention relates to a product for the targeted release of active substances, especially detergents and/or cosmetic active substances. The inventive product has a layer structure, one layer being impermeable to the active substance and another layer being permeable to the active substance. The two layers define a compartment between them which contains the active substance and optionally a gas-releasing component. The product is preferably suitable for single use and can be used as a cosmetic agent and/or as a cleaning agent.

Priority: DE200510012247 Applic. Date: 2005-03-15; WO2006EP01391 Applic. Date: 2006-02-16

Inventor: ROREGER MICHAEL [DE]; LI QIAN-YI [DE]; SCHNITZLER IRIS [DE]; SCHUMACHER DIERK [DE]


Application No.: US20080145415A1  Published: 19/Jun/2008

Title: Bioresorbable Fillers Constituted by Phospholipid Liposomes and Hyaluronic Acid and/or the Derivatives Thereof

Applicant/Assignee:

Application No.: 11/920009   Filing Date: 21/Apr/2006

Abstract:The present invention describes a new bioresorbable filler constituted by hyaluronic acid and/or the derivatives thereof structured with/in phospholipid liposomes, which increase the residence time of the starting polymer in situ. Said fillers described herein are substantially intended to increase the soft tissues in aesthetic surgery and dermocosmetics for the correction of mild to medium defects, but because of their special characteristics they can also be used in other fields of application.

Priority: WO2006EP03898 Applic. Date: 2006-04-21

Inventor: CALLEGARO LANFRANCO [IT]; GALESSO DEVIS [IT]; TAGLIENTI ANNA [IT]


Application No.: US20080145456A1  Published: 19/Jun/2008

Title: Medicated Production For Local Use Based On Natural Materials

Applicant/Assignee:

Application No.: 11/908700   Filing Date: 25/May/2006

Abstract:The subject of the invention is a medicated product for local use based on natural materials which said product is suitable for alleviating respectively eliminating pain of different locomotor complaints of the body applying the product through the skin surface. The product according to the invention contains menthol in water solution, ethylene-diamine-tetra-acetic acid-alkali metal, salt (EDTA), furthermore in given case it contains carrier, diluter and/or other auxiliary substances applied in producing products for local use, characterized by that, the product contains essential oils furthermore non-ionic surface-active emulsifying agent and substances in the composition of the product as follows:

Aethereum gerani 0.1 . . . 3 mass %, preferably 1.5 mass %, Aethereum rosmarini 0.1 . . . 2 mass %, preferably 0.5 mass %, Aethereum citri 0.5 . . . 3 mass %, preferably 1 mass %, Mentholum 0.1 . . . 3 mass %, preferably 1 mass %, EDTA 2Na 1 . . . 6 mass %, preferably 3 mass %.

Priority: HU20050000530 Applic. Date: 2005-05-25; WO2006HU00048 Applic. Date: 2006-05-25

Inventor: HUTAS ISTVAN [HU]


Application No.: US20080146478A1  Published: 19/Jun/2008

Title: ENCAPSULATED ACTIVE MATERIAL CONTAINING NANOSCALED MATERIAL

Applicant/Assignee: INTERNATIONAL FLAVORS & FRAGRANCES INC

Application No.: 11/611501   Filing Date: 15/Dec/2006

Abstract:The present invention is directed to novel capsules containing active material and nanoscaled material and to methods for making capsules with enhanced performance and stability. The capsules are well suited for use in personal care applications, laundry products and perfume and fragrance products.

Priority:

Inventor: LEI YABIN [US]; POPPLEWELL LEWIS MICHAEL [US]; JOYCE CAROL [US]


Application No.: US20080146545A1  Published: 19/Jun/2008

Title: Macrocyclic compounds useful as inhibitors of kinases and HSP90

Applicant/Assignee:

Application No.: 11/891652   Filing Date: 10/Aug/2007

Abstract:Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

Priority: US20060837154P Applic. Date: 2006-08-11; US20060858731P Applic. Date: 2006-11-13

Inventor: WINSSINGER NICOLAS [FR]; BARLUENGA SOFIA [FR]; KARPLUS MARTIN [US]


Application No.: US20080146633A1  Published: 19/Jun/2008

Title: COMPOSITIONS FOR SKIN LIGHTENING AND TONING DOWN PIGMENT DISORDERS, COMPRISING CREATININE AND/OR CREATININE DERIVATIVES AS ACTIVE SUBSTANCES

Applicant/Assignee: GOLDSCHMIDT GMBH

Application No.: 12/038272   Filing Date: 27/Feb/2008

Abstract:Compositions are provided for lightening skin and toning down pigment disorders which include, as active substances, at least one of the compounds of the general formula (I) and/or salts thereof in which R<1 >is H, alkyl, hydroxyalkyl, or a carboxyalkyl radical having 2 to 30 carbon atoms

and R<2 >is H or a hydrocarbon radical having 1 to 30 carbon atoms which may be branched or unbranched and may or may not contain double bonds.

Priority: EP20020003483 Applic. Date: 2002-02-15; US2003-367229 Applic. Date: 2003-02-14

Inventor: LERSCH PETER [DE]; WEITEMEYER CHRISTIAN [DE]


Application No.: US20080146806A1  Published: 19/Jun/2008

Title: Octahydropyrrolo[2,3C]Pyridine Derivatives and Pharmaceutical Use Thereof

Applicant/Assignee: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V

Application No.: 11/658084   Filing Date: 20/Jul/2005

Abstract:The present invention is related to octahydropyrrolo[2,3,c]pyridine derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Priority: EP20040103483 Applic. Date: 2004-07-21; US20040589621P Applic. Date: 2004-07-21; WO2005EP53501 Applic. Date: 2005-07-20

Inventor: SWINNEN DOMINIQUE [FR]; BOMBRUN AGNES [FR]


Application No.: US20080149504A1  Published: 26/Jun/2008

Title: Child's Fragrant Cleaning Implement

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/024435   Filing Date: 01/Feb/2008

Abstract:A disposable child sized cleaning implement is provided. The disposable child sized cleaning implement is releasably carrying a personal care composition which comprises a fragrance composition.

Priority: US2004-948476 Applic. Date: 2004-09-23; US2003-737236 Applic. Date: 2003-12-16

Inventor: BENJAMIN JOYCE MARIE [US]; MASON MICHAEL WAYNE [US]; MASON JENNA [US]


Application No.: US20080152607A1  Published: 26/Jun/2008

Title: POLYCONDENSATE, COMPOSITION CONTAINING A POLYCONDENSATE, METHOD OF TREATMENT, AND METHOD OF PREPARATION

Applicant/Assignee: L'OREAL

Application No.: 11/766118   Filing Date: 21/Jun/2007

Abstract:The present application relates to a polycondensate that can be obtained by reaction: of polyol containing 3 to 6 hydroxyl groups

of non-aromatic, saturated or unsaturated mono-carboxylic acid

of aromatic monocarboxylic acid containing 7 to 11 carbon atoms

and of polycarboxylic acid, saturated or unsaturated, or even aromatic, linear, branched and/or cyclic, containing at least 2 carboxyl groups COOH

and/or a cyclic anhydride of such a polycarboxylic acid. The application also relates to a method of cosmetic treatment employing said composition, the polycondensate thus defined and a method of preparation of the polycondensate.

Priority: FR20060052591 Applic. Date: 2006-06-22; US20060817073P Applic. Date: 2006-06-29

Inventor: MALLE GERARD [FR]; MONDET JEAN [FR]; BLIN XAVIER [FR]; RODRIGUEZ IVAN [FR]; GIUSTINIANI PASCAL [FR]


Application No.: US20080152894A1  Published: 26/Jun/2008

Title: Treated substrates having improved delivery of impregnated ingredients

Applicant/Assignee: AMCOL HEALTH & BEAUTY SOLUTIONS

Application No.: 11/643327   Filing Date: 20/Dec/2006

Abstract:An article of manufacture containing polymeric microparticles, optionally loaded with an active agent, impregnated into a porous substrate is disclosed.

Priority:

Inventor: BEIHOFFER THOMAS W [US]; CURETON KEVIN [US]


Application No.: US20080153781A1  Published: 26/Jun/2008

Title: ANTI-WRINKLE AGENT

Applicant/Assignee: R & R INC

Application No.: 12/040374   Filing Date: 29/Feb/2008

Abstract:A medicament having an anti-wrinkle action, which comprises as an active ingredient a retinoid having a fundamental structure of a phenyl substituted carbamoyl benzoic acid or a phenyl substituted carboxamide benzoic acid (for example, 4-(2,4-bistrimethylsilylphenylcarboxamide) benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid, or the like).

Priority: JP20040068454 Applic. Date: 2004-03-11; US2004-932097 Applic. Date: 2004-09-02

Inventor: SHUDO KOICHI [JP]; FUJII SEISHIRO [JP]


Application No.: US20080153786A1  Published: 26/Jun/2008

Title: Controlled release of drugs into/through the skin

Applicant/Assignee: GALDERMA S.A

Application No.: 12/000187   Filing Date: 10/Dec/2007

Abstract:The slow and sustained, controlled release of a drug into and through the skin includes topically applying onto the skin of an individual in need of such treatment, a composition containing at least one solubilized drug, at least one film-forming silicone, and at least one volatile solvent.

Priority: WO2006EP05831 Applic. Date: 2006-05-22

Inventor: ANDRES PHILIPPE [FR]; MALLARD CLAIRE [FR]


Application No.: US20080153839A1  Published: 26/Jun/2008

Title: USE OF ANISIC ACID FOR PROMOTING DESQUAMATION

Applicant/Assignee: L'OREAL

Application No.: 11/954416   Filing Date: 12/Dec/2007

Abstract:Use of anisic acid or a derivative thereof for promoting desquamation of the skin and/or for stimulating epidermal renewal. Associated compositions. Especially useful for improving the radiance of the complexion and/or the grain of the skin and/or for smoothing out the skin's microrelief, and/or for attenuating age spots.

Priority: FR20060055445 Applic. Date: 2006-12-12; US20060870850P Applic. Date: 2006-12-20

Inventor: COTTON THIERRY [FR]; AMAR DAVID [FR]


Application No.: US20080153901A1  Published: 26/Jun/2008

Title: Avermectin/benzoyl peroxide compositions for treating afflictions of the skin, e.g., rosacea

Applicant/Assignee: GALDERMA S.A

Application No.: 12/000181   Filing Date: 10/Dec/2007

Abstract:The invention relates to a pharmaceutical composition, especially a dermatological composition, containing, in a physiologically acceptable medium, at least one compound of the avermectin family, and benzoyl peroxide, and also to its use for the manufacture of a medicament for treating skin conditions, especially rosacea.

Priority: FR20050005917 Applic. Date: 2005-06-10; WO2006FR01300 Applic. Date: 2006-06-08

Inventor: KAOUKHOV ALEXANDRE [FR]; PERNIN COLETTE [FR]


Application No.: US20080153912A1  Published: 26/Jun/2008

Title: Compositions and Methods of Their Use for Improving the Condition and Appearance of Skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 12/025133   Filing Date: 04/Feb/2008

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and/or aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include active agents which increase expression levels of genes associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and/or aesthetic appearance of skin.

Priority: US2004-021242 Applic. Date: 2004-12-22

Inventor: DRYER LAURENCE [US]; PTCHELINTSEV DMITRI [US]


Application No.: US20080153916A1  Published: 26/Jun/2008

Title: Use of Adamantyl Methoxydiphenyl Propenoic Acid For the Treatment of Acne

Applicant/Assignee: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A

Application No.: 11/911749   Filing Date: 05/May/2006

Abstract:The use of a substance belonging to the class of atypical retinoids for the topical treatment of acne is described. In particular the effects on an animal model for this skin disease of a pharmaceutical or cosmetic compound for topical use containing adamantyl methoxydiphenyl propenoic acid formulated in a gel are demonstrated.

Priority: IT2005RM00248 Applic. Date: 2005-05-20; WO2006EP62088 Applic. Date: 2006-05-05

Inventor: PISANO CLAUDIO [IT]; VESCI LOREDANA [IT]


Application No.: US20080159569A1  Published: 03/Jul/2008

Title: Method and Arrangement for the Sensitive Detection of Audio Events and Use Thereof

Applicant/Assignee:

Application No.: 11/817704   Filing Date: 03/Mar/2006

Abstract:The invention relates to a method, to a device and to uses thereof for the sensitive detection of audio events in order to obtain sensations and feelings of the living skin. The audio event is broken down in to several spectral ranges, and from the signals which represent said range, control voltages are determined for a defined selection of predetermined transmitters which act upon and/or in the living skin. The selection and allocation of the control voltages is dependant on a signal analysis which uses signals which represent the spectral range. The invention relates both to the rendering of deaf people sensitive to music and to the transmission of signals to deaf people.

Priority: DE200510011358 Applic. Date: 2005-03-04; WO2006DE00410 Applic. Date: 2006-03-03

Inventor: HANSEN JENS [DE]


Application No.: US20080159957A1  Published: 03/Jul/2008

Title: Anti-Cancer and Anti-Infectious Disease Compositions and Methods for Using Same

Applicant/Assignee:

Application No.: 10/530000   Filing Date: 01/Oct/2003

Abstract:The present invention provides methods and compositions for treating and/or preventing cancer in a subject via administration of a non-pathogenic virus. The present invention also provides methods and compositions for treating and/or preventing infectious diseases in a subject via administration of a non-pathogenic.

Priority: US20020414649P Applic. Date: 2002-10-01; US20020414660P Applic. Date: 2002-10-01; WO2003US31320 Applic. Date: 2003-10-01

Inventor: KAVANAUGH W MICHAEL [US]; MACKICHAN MARY LEE [US]; SLOANE DAVID L [US]


Application No.: US20080159970A1  Published: 03/Jul/2008

Title: KIT COMPRISING SILICONE COMPOUNDS AND A COSMETIC AND/OR DERMATOLOGICAL ACTIVE AGENT

Applicant/Assignee: L'OREAL

Application No.: 11/961031   Filing Date: 20/Dec/2007

Abstract:Kit for making up or non-therapeutically caring for keratin material(s), containing at least 0.01% by weight relative to the total weight of the composition of a moisturizer agent for improving the appearance of the keratin materials, at least two different compositions conditioned separately, the kit comprising at least one compound X and at least one compound Y, and at least one catalyst, with at least one of the compounds X and Y being a silicone compound, and the compounds X and Y being capable of reacting together via a hydrosilylation reaction in the presence of a catalyst, when they are placed in contact with each other, the moisturizer agent(s) being present in at least one of the two first compositions, or in a third composition separate from the first two.

Priority: US20060870915P Applic. Date: 2006-12-20

Inventor: WILLEMIN CLAUDIE [FR]


Application No.: US20080159971A1  Published: 03/Jul/2008

Title: USE OF DHEA OR PRECURSORS OR METABOLIC DERIVATIVES THEREOF AS A DEPIGMENTING AGENT

Applicant/Assignee: L'OREAL S.A

Application No.: 12/037413   Filing Date: 26/Feb/2008

Abstract:The use of DHEA or at least one of its biological precursors or of its metabolic derivatives in or for the manufacture of a composition for topical application to the skin, as a pigmentation regulator for the skin or its superficial growths, especially as a depigmenting and/or bleaching agent for the skin, in particular in the treatment of pigmentation marks, and as a pro-pigmenting agent for superficial body growths.

Priority: FR19990012773 Applic. Date: 1999-10-13; US2000-686997 Applic. Date: 2000-10-12

Inventor: DE LACHARRIERE OLIVIER [FR]; NOUVEAU STEPHANIE [FR]


Application No.: US20080160034A1  Published: 03/Jul/2008

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENENTECH, INC

Application No.: 11/572702   Filing Date: 23/Aug/2005

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20040604323P Applic. Date: 2004-08-25; WO2005US29782 Applic. Date: 2005-08-23

Inventor: BRENNAN JANE [GB]; DE SAUVAGE FREDERIC J [US]; YE WEILAN [US]; EDWARDS JOEL A [US]; HUANG WENHU [US]; MONTGOMERY CHARLES [US]; PAYNE BOBBY JOE [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; VOGEL PETER [US]


Application No.: US20080160109A1  Published: 03/Jul/2008

Title: Compositions and methods of their use for improving the condition and appearance of skin

Applicant/Assignee: AVON PRODUCTS INC

Application No.: 11/647648   Filing Date: 29/Dec/2006

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents, or synthetic equivalents thereof, which inhibit or decrease expression of C-reactive protein expression, production or secretion, thereby reducing, inhibiting, or ameliorating dermatological signs of aging. The compositions of the invention may be topically applied to the skin, or are delivered by directed means to a site in need thereof, in an amount effective in improving the condition and aesthetic appearance of skin.

Priority:

Inventor: DRYER LAURENCE [US]; TAFURI SHERRIE R [US]; PTCHELINTSEV DMITRI [US]


Application No.: US20080161328A1  Published: 03/Jul/2008

Title: 5-Substituted quinazolinone derivatives and compositions comprising and methods of using the same

Applicant/Assignee: CELGENE CORPORATION

Application No.: 11/904551   Filing Date: 26/Sep/2007

Abstract:Provided are 5-substituted quinazolinone compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US20060847471P Applic. Date: 2006-09-26

Inventor: MULLER GEORGE W [US]; MAN HON-WAH [US]


Application No.: US20080161341A1  Published: 03/Jul/2008

Title: Novel imidazothiazoles and imidazoxazoles

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 11/973147   Filing Date: 05/Oct/2007

Abstract:The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Priority: US20060849873P Applic. Date: 2006-10-06

Inventor: CALDERWOOD DAVID J [US]; FRANK KRISTINE E [US]; BORHANI DAVID W [US]; DAVIS HEATHER M [US]; JOSEPHSOHN NATHAN S [US]; SKINNER BARBARA S [US]


Application No.: US20080161377A1  Published: 03/Jul/2008

Title: Use of L-2-thiohistidine or one of its derivatives as a depigmenting agent in cosmetics

Applicant/Assignee: LVMH RECHERCHE

Application No.: 12/005823   Filing Date: 28/Dec/2007

Abstract:The invention relates to the use of L-2-thiohistidine, or a cosmetically acceptable salt or ester of its acid group, as a depigmenting agent in a cosmetic composition or for the preparation of a cosmetic composition. It further relates to a method of cosmetic care for toning down or eliminating pigment spots on the skin and/or lightening the complexion by the application of this cosmetic composition. The invention provides a highly depigmenting composition.

Priority: FR20060056063 Applic. Date: 2006-12-29

Inventor: ANDRE PATRICE [FR]; MARTEAU CLARISSE [FR]; RENIMEL ISABELLE [FR]; MOREAU MARIELLE [FR]


Application No.: US20080161394A1  Published: 03/Jul/2008

Title: Cosmetic composition comprising at least one volatile carbonic acid ester

Applicant/Assignee:

Application No.: 11/984726   Filing Date: 21/Nov/2007

Abstract:The present application relates to a cosmetic composition comprising at least one carbonic acid ester corresponding to formula (I) below: R1-O-CO-O-R2 (I) in which R1 and R2 are identical or different and represent a linear or branched hydrocarbon-based radical, with the proviso that: when R1 and R2 are linear, they each contain from 1 to 6 carbon atoms, with 6<=R1+R2<=7

and when R1 and/or R2 are branched, they each contain from 1 to 8 carbon atoms, with 6<=R1+R2<=9. This composition can be used as a product for caring for and/or making up keratin materials, in particular the skin, the lips and/or the integuments.

Priority: FR20060055063 Applic. Date: 2006-11-23; FR20060055069 Applic. Date: 2006-11-23; FR20060055071 Applic. Date: 2006-11-23; FR20060055074 Applic. Date: 2006-11-23; US20060872776P Applic. Date: 2006-12-05; US20060872775P Applic. Date: 2006-12-05; US20060872481P Applic. Date: 2006-12-04; US20060872483P Applic. Date: 2006-12-04

Inventor: FOURON JEAN-YVES [FR]; AUGUSTE FREDERIC [FR]


Application No.: US20080161746A1  Published: 03/Jul/2008

Title: PROTECTED LITHIUM ELECTRODES FOR ELECTRO-TRANSPORT DRUG DELIVERY

Applicant/Assignee: POLYPLUS BATTERY COMPANY

Application No.: 11/946791   Filing Date: 28/Nov/2007

Abstract:This invention provides new and novel devices and methods for administering lithium (Li) ions to a mammalian subject, especially the delivery of lithium (Li) ions to a body component for example across a body or tissue surface such as skin or a mucosal membrane, or for delivery of lithium ions directly to bodily fluids in a controllable and reproducible manner. In certain embodiments the device comprises a donor electrode that is a donor of a lithium ion

a protective architecture that is ionically conductive to the lithium ion, configured for application to a skin surface and positioned to isolate said donor electrode from the skin surface

and a counter electrode assembly configured for application to a skin surface, where said counter electrode assembly comprises a counter electrode operably coupled to said donor electrode.

Priority: US20060867553P Applic. Date: 2006-11-28; US20070970729P Applic. Date: 2007-09-07

Inventor: VISCO STEVEN J [US]; NIMON YEVGENIY S [US]


Application No.: US20080161782A1  Published: 03/Jul/2008

Title: MICROPORE DELIVERY OF ACTIVE SUBSTANCES

Applicant/Assignee: RELIANT TECHNOLOGIES, INC

Application No.: 11/925697   Filing Date: 26/Oct/2007

Abstract:A method and device for delivering active substances into and through the skin for treatment of the skin during and/or following fractional laser radiation treatment of the skin are described.

Priority: US20060863115P Applic. Date: 2006-10-26

Inventor: CHAN KIN F [US]; HANTASH BASIL M [US]; BEDI VIKRAMADITYA P [US]; FRANGINEAS GEORGE [US]


Application No.: US20080166303A1  Published: 10/Jul/2008

Title: Colored or colorable foamable composition and foam

Applicant/Assignee:

Application No.: 11/900328   Filing Date: 10/Sep/2007

Abstract:There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1) a flowable carrier composition

2) a color agent

wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent

b) a propellant at a concentration of about 3% to about 25% by weight of the total composition

wherein the base composition has a first color

and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.

Priority: US20060843144P Applic. Date: 2006-09-08

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20080166311A1  Published: 10/Jul/2008

Title: Use of agglomerated hydroxyethylcellulose in pharmaceutical, personal care and household care applications

Applicant/Assignee:

Application No.: 12/008217   Filing Date: 09/Jan/2008

Abstract:The present invention is related to the use of glyoxal-free compositions, more particularly, to the use of hydroxyethylcellulose agglomerated with low molecular weight hydroxyethylcellulose in consumer products, in particular, pharmaceutical, personal care (excluding oral care compositions), as well as household care applications.

Priority: US20070879855P Applic. Date: 2007-01-10

Inventor: MODI JASHAWANT J [US]


Application No.: US20080166335A1  Published: 10/Jul/2008

Title: Slimming Cosmetic Composition Comprising a Metalloproteinase as an Active Agent

Applicant/Assignee:

Application No.: 10/592457   Filing Date: 08/Mar/2005

Abstract:The invention relates to a slimming cosmetic composition comprising, by way of an active agent, at least one inhibitor of metalloproteinases -2 and/or -9 or a plant extract containing said metalloproteinase inhibitor. The invention also relates to the use of an inhibitor of metalloproteinases -2 and/or -9 or a plant extract containing said inhibitor in a slimming cosmetic product. The invention further relates to the cosmetic use of an inhibitor of metalloproteinases -2 and/or -9 or a plant extract containing said inhibitor as an agent that prevents adipocyte differentiation for the preparation of a slimming composition.

Priority: FR20040050461 Applic. Date: 2004-03-08; WO2005FR00554 Applic. Date: 2005-03-08

Inventor: COURTIN OLIVIER [FR]


Application No.: US20080166413A1  Published: 10/Jul/2008

Title: Topical pharmaceutical formulations and methods of treatment

Applicant/Assignee: PHARMAKODEX LIMITED

Application No.: 12/077331   Filing Date: 19/Mar/2008

Abstract:In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35 DEG C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.

Priority: GB20000015617 Applic. Date: 2000-06-26; US2002-312475 Applic. Date: 2002-12-23; WO2001GB02823 Applic. Date: 2001-06-26

Inventor: STANIFORTH JOHN NICHOLAS [GB]; TOBYN MICHAEL JOHN [GB]


Application No.: US20080166436A1  Published: 10/Jul/2008

Title: Composition for normalizing otitis externa in mammals

Applicant/Assignee: APPERON INC

Application No.: 11/651745   Filing Date: 10/Jan/2007

Abstract:Otitis externa is a condition of the outer ear canal in mammalian animals, especially dogs and cats, marked by inflammation and infection of tissue, buildup of ear wax, and draining of ear exudate. Symptoms of infection are, among others, excessive cerumen, alopecia in the ear flap, crusts, and ear pruritis. Typical causes of otitis externa are fungi, bacteria, and mites. A medicating mixture in accordance with the invention, comprising cold-pressed citrus oil, deionized water, and, optionally, hydrolysates of milk proteins, when applied topically to an infected ear canal can produce significant reduction in symptoms. In a clinical study, 95% of an infected population of dogs were normalized without other or further treatment.

Priority:

Inventor: PUSILLO GARY [US]


Application No.: US20080167360A1  Published: 10/Jul/2008

Title: Cycloalkylidene Compounds as Selective Estrogen Receptor Modulators

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION GLAXOSMITHKLINE LLC

Application No.: 11/915436   Filing Date: 24/May/2006

Abstract:The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.

Priority: US20050684433P Applic. Date: 2005-05-25; WO2006US20185 Applic. Date: 2006-05-24

Inventor: FANG JING [US]; HEYER DENNIS [US]; KATAMREDDY SUBBA REDDY [US]; BATCHELOR KENNETH WILLIAM [US]; CALDWELL RICHARD DANA [US]


Application No.: US20080167375A1  Published: 10/Jul/2008

Title: TREATMENT OF CUTANEOUS NEUROGENIC INFLAMMATION

Applicant/Assignee: ASTION PHARMA A/S

Application No.: 11/760289   Filing Date: 08/Jun/2007

Abstract:The glyceryl fatty acid monoester of octanoic acid, i.e. 1-glyceryl monocaprylate has, unlike other glyceryl fatty acid esters, such as 1-glyceryl monocaprate, been shown to inhibit cutaneous neurogenic inflammation. Therefore, this invention features uses and dermatological compositions of 1-glyceryl monocaprylate or analogues thereof for the treatment of cutaneous neurogenic inflammation, such as pruritus, pruritic skin disorders and seborrheic dermatitis, even without the need of co-administering other anti-inflammatory agents.

Priority: DK20060000776 Applic. Date: 2006-06-08

Inventor: WEIDNER MORTEN SLOTH [DK]


Application No.: US20080169215A1  Published: 17/Jul/2008

Title: Cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/009051   Filing Date: 16/Jan/2008

Abstract:The present invention relates to a composition comprising from about 0.1% to about 10% of a hydrophobic structuring agent

from about 0.1% to about 10% of a hydrophilic surfactant

from about 0.01% to about 5% of a non-crosslinked water-soluble polymer

and water, wherein the composition has a viscosity above about 15,000 cps, and has a highest G' below about 15,000 dyne/cm<2 >and a highest tan delta above about 0.4 in the angular frequency range of from about 0.1 rad/sec to about 1 rad/sec. The present invention also relates to a cosmetic product comprising a) a composition comprising from about 0.1% to about 10% of a hydrophobic structuring agent, from about 0.1% to about 10% of a hydrophilic surfactant

from about 0.01% to about 5% of a non-crosslinked water soluble polymer and water, and b) a container which contains the composition, wherein the composition has a viscosity above 15,000 cps, and recovers its surface flatness to have a Sa below 80 within about 24 hours when its surface is distorted to have a Sa above about 150.

Priority: US20070880598P Applic. Date: 2007-01-16

Inventor: TANAKA HIDEKAZU [JP]; KARITA MASAFUMI [JP]; UCHIKAWA SATOKO [JP]; SAITO YUJIN [JP]; MATSUBARA AKIRA [JP]


Application No.: US20080170904A1  Published: 17/Jul/2008

Title: SPREADING IMPLEMENT

Applicant/Assignee: ACRUX DDS PTY LTD

Application No.: 11/678673   Filing Date: 26/Feb/2007

Abstract:This invention relates to an implement 1 for applying a volume of liquid to a treatment surface. The implement includes a support means 3 onto which is mounted a receptacle 2, the receptacle defining a reservoir space 4 which receives the liquid. The receptacle includes a wall 6 having a working surface that is used to spread the liquid over the treatment surface. The wall 6 is resiliently deformable so in use the working surface maintains contact with the treatment surface when spreading the liquid. The implement has a specific application in applying a transdermal lotion to the axilla area of the user. The invention also relates to a system for transdermal administration of a physiological active agent from a liquid composition and a method of conducting the same.

Priority: US20070884482P Applic. Date: 2007-01-11

Inventor: BAYLY PETER [AU]; BAYLY MARK SIMON [AU]; AHLSTROM MAGNUS [AU]


Application No.: US20080171002A1  Published: 17/Jul/2008

Title: Products For Receptor Mediated Activation And Maturation Of Monocyte-Derived Dendritic Cells By A Phosphorylated Glucomannane Polysaccharide

Applicant/Assignee: GOURMETCEUTICALS, LLC

Application No.: 11/781135   Filing Date: 20/Jul/2007

Abstract:Phosphorylated glucomannan polysaccharide compositions are shown to effectively enhance healthy immune function. Dosage forms including pills, sprays, functional foods and cosmetics may achieve this benefit while being essentially free of storage protein from nongerminated seeds of Ricinus communis.

Priority: US20060832316P Applic. Date: 2006-07-20

Inventor: TUDURI JOSE ANTONIO MATJI [ES]; GOMEZ-PAMO ANTONIO F GUERRERO [ES]; LEBRERO JOSE LUIS ALONSO [ES]; LINDEMANN GARRETT [US]; CABRERA MANUEL LOPEZ [ES]; RODRIGUEZ PEDRO MAJANO [ES]; OTERO RICARDO MORENO [ES]; GOMEZ DIEGO SERRANO [ES]; LOPEZ ANGEL CORBI [ES]; VILCHEZ SAMUEL MARTIN [ES]


Application No.: US20080171005A1  Published: 17/Jul/2008

Title: Composition for making-up the skin comprising at least one resin, at least one block copolymer and at least one solid fatty substance, free from volatile oil

Applicant/Assignee:

Application No.: 12/000936   Filing Date: 19/Dec/2007

Abstract:Disclosed herein is a composition for make-up and/or care of the skin comprising a fatty phase, comprising: at least one resin of number average molecular weight less than or equal to 10,000 g/mol, selected from rosin, derivatives of rosin, and hydrocarbon resins, at least one hydrocarbon block copolymer, at least one fatty substance whose melting point is greater than 25 DEG C. chosen from waxes and pasty fatty substances, wherein said composition comprises less than 5% of volatile oil.

Priority: FR20060055650 Applic. Date: 2006-12-19; FR20060055651 Applic. Date: 2006-12-19; US20070878419P Applic. Date: 2007-01-04; US20070878420P Applic. Date: 2007-01-04

Inventor: JACQUES VERONIQUE [FR]; SCHWARTZ VERONIQUE [FR]; BLIN XAVIER [FR]; ILEKTI PHILIPPE [FR]


Application No.: US20080171014A1  Published: 17/Jul/2008

Title: Interleukin-13 binding proteins

Applicant/Assignee:

Application No.: 11/899819   Filing Date: 07/Sep/2007

Abstract:The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

Priority: US20060843249P Applic. Date: 2006-09-08

Inventor: WU CHENGBIN [US]; DIXON RICHARD W [US]; BELK JONATHAN P [US]; ARGIRIADI MARIA A [US]; YING HUA [US]; CUFF CAROLYN A [US]; MELIM TERRY L [US]; KUMAR SHANKAR [US]; HINTON PAUL R [US]; CHEN YAN [US]


Application No.: US20080171036A1  Published: 17/Jul/2008

Title: TACI ANTIBODIES AND USES THEREOF

Applicant/Assignee:

Application No.: 11/841802   Filing Date: 20/Aug/2007

Abstract:TACI receptor antibodies are provided. The TACI antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the TACI antibodies are also provided.

Priority: US2003-626914 Applic. Date: 2003-07-25; US20020398530P Applic. Date: 2002-07-25

Inventor: CHUNTHARAPAI ANAN [US]; GREWAL IQBAL [US]; KIM KYUNG JIN [US]; YAN MINHONG [US]


Application No.: US20080171076A1  Published: 17/Jul/2008

Title: Dermatological and/or Cosmetic Composition Containing Polypeptides

Applicant/Assignee:

Application No.: 10/589863   Filing Date: 23/Dec/2004

Abstract:The present invention relates to the use of proteins of the UCP family, or UCP protein polypeptide or peptide fragments, as an active agent, alone or in association with at least one other active agent, in or for the preparation of a pharmaceutical and/or dermatological and/or cosmetic composition. The invention also relates to any composition containing the aforementioned active ingredient, as well as its use as a slimming agent.

Priority: FR20040001593 Applic. Date: 2004-02-18; WO2004FR03357 Applic. Date: 2004-12-23

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; BOTTO JEAN-MARIE [FR]


Application No.: US20080171729A1  Published: 17/Jul/2008

Title: Use Of A Steroid For Enhancement Of Skin Permeability

Applicant/Assignee: NOVARTIS AG

Application No.: 11/571895   Filing Date: 15/Jul/2005

Abstract:A method for enhancing skin permeability by administration of a tetracyclic compound and improved methods for treatment of disorders by administration of a tetracyclic compound and a pharmaceutically active compound.

Priority: GB20040017205 Applic. Date: 2004-08-02; US20040605328P Applic. Date: 2004-08-27; GB20040015994 Applic. Date: 2004-07-16; WO2005EP07740 Applic. Date: 2005-07-15

Inventor: MEINGASSNER JOSEF GOTTFRIED [AT]


Application No.: US20080175825A1  Published: 24/Jul/2008

Title: Mixed cell populations for tissue repair and separation technique for cell processing

Applicant/Assignee:

Application No.: 11/983008   Filing Date: 05/Nov/2007

Abstract:The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing. Embodiments are also applicable to harvesting (and/or washing) particles within a liquid or solution within a chamber.

Priority: US20060856504P Applic. Date: 2006-11-03; US20070932702P Applic. Date: 2007-06-01

Inventor: HAMPSON BRIAN [US]; GOLTRY KRISTIN [US]; SMITH DOUG [US]; ROWLEY JONATHAN A [US]; VENTURI NAIA [US]


Application No.: US20080176848A1  Published: 24/Jul/2008

Title: N-Sulphonylpyrroles and Their Use as Histone Deacetylase Inhibitors

Applicant/Assignee: NYCOMED GMBH 4SC AG

Application No.: 11/885832   Filing Date: 14/Mar/2006

Abstract:Compounds of a certain formula (I) in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Priority: EP20050102019 Applic. Date: 2005-03-15; EP20050108735 Applic. Date: 2005-09-21; WO2006EP60712 Applic. Date: 2006-03-14

Inventor: MAIER THOMAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [DE]; ZIMMERMANN ASTRID [DE]; SCHNEIDER SIEGFRIED [DE]; GEKELER VOLKER [DE]


Application No.: US20080176928A1  Published: 24/Jul/2008

Title: Avermectin/hydrocortisone compositions for treating afflictions of the skin, E.G., rosacea

Applicant/Assignee: GALDERMA S.A

Application No.: 12/000186   Filing Date: 10/Dec/2007

Abstract:Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and hydrocortisone or salt, ester or derivative thereof, are useful for treating afflictions of the skin, especially rosacea.

Priority: FR20050005919 Applic. Date: 2005-06-10; WO2006FR01299 Applic. Date: 2006-06-08

Inventor: KAOUKHOV ALEXANDRE [FR]; PERNIN COLETTE [FR]


Application No.: US20080176954A1  Published: 24/Jul/2008

Title: Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 12/076860   Filing Date: 24/Mar/2008

Abstract:Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4 DEG C. and 40 DEG C.

Priority: FR20010016747 Applic. Date: 2001-12-21; US2002-326389 Applic. Date: 2002-12-23; US20020351382P Applic. Date: 2002-01-28

Inventor: ORSONI SANDRINE [FR]; WILLCOX NATHALIE [FR]


Application No.: US20080177217A1  Published: 24/Jul/2008

Title: Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation

Applicant/Assignee:

Application No.: 11/596525   Filing Date: 16/May/2005

Abstract:Treating of localized bacterial infection, comprising locally applying Taurolidine to the infection. A device for insertion into the body, the device comprising Taurolidine to render the device infection resistant. A medication for treating bacterial infections, comprising Taurolidine carried by one of: gels, liquid, thixotropic gels, colloidal mixtures, dispensal suspensions, injectable polymers, or a microparticle. A method for treating blood, comprising: removing blood from the body

treating the blood with Taurolidine

and returning the treated blood.

Priority: US20040571272P Applic. Date: 2004-05-14; WO2005EP05438 Applic. Date: 2005-05-16

Inventor: POLASCHEGG HANS-DIETRICH [AT]


Application No.: US20080181858A1  Published: 31/Jul/2008

Title: Sunscreen Compositions

Applicant/Assignee: NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION

Application No.: 11/955346   Filing Date: 12/Dec/2007

Abstract:Sunscreen compositions comprising one or more sunscreen agents (inorganic and combinations of inorganic and organic), one or more film forming polymers (synthetic or naturally derived), and heat treated xanthan gum. The sunscreen composition provides higher pre- and post-immersion SPF values, as well as a means for reducing the amount of sunscreen agents in a formulation without forfeiting efficacy.

Priority: US20070887370P Applic. Date: 2007-01-31; US20070951090P Applic. Date: 2007-07-20; US20070987948P Applic. Date: 2007-11-14

Inventor: DAVIS JENNIFER [US]; PETERSEN DOREEN [US]


Application No.: US20080181905A1  Published: 31/Jul/2008

Title: Nanoemulsion Vaccines

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Application No.: 11/966763   Filing Date: 28/Dec/2007

Abstract:The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

Priority: US2002-162970 Applic. Date: 2002-06-05; US20010296048P Applic. Date: 2001-06-05

Inventor: BAKER JAMES R [US]; HAMOUDA TAREK [US]


Application No.: US20080181953A1  Published: 31/Jul/2008

Title: COMPOSITION CONTAINING A TENSIONING POLYMER AND HYBRID PARTICLES, METHODS OF USE

Applicant/Assignee: L'OREAL

Application No.: 11/970560   Filing Date: 08/Jan/2008

Abstract:Composition containing, in a physiologically acceptable medium, a tensioning polymer and organic-mineral hybrid particles. Process, particularly for facial skin, in particular wrinkled skin, involving the application of the invention composition to the skin.

Priority: FR20070052577 Applic. Date: 2007-01-09; US20070885033P Applic. Date: 2007-01-16

Inventor: CASSIN GUILLAUME [FR]


Application No.: US20080181956A1  Published: 31/Jul/2008

Title: Oil-in-water personal care composition

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/700379   Filing Date: 31/Jan/2007

Abstract:A personal care composition in the form of an oil-in-water emulsion is disclosed that provides improves skin feel. The personal care composition comprises from a silicone elastomer

a silicone fluid

a particulate material having a refractive index of less than about 1.8

a polymeric thickener

and water. The personal care composition may be substantially devoid of opacifying particulate material. A consumer product comprising the personal care composition is also disclosed. The consumer product allows for the application of the personal care composition to the skin or other keratinous tissue.

Priority:

Inventor: HA ROBERT BAO KIM [US]; TANNER PAUL ROBERT [US]; ELSBROCK ROBERT JOHN [US]


Application No.: US20080181963A1  Published: 31/Jul/2008

Title: Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 12/076859   Filing Date: 24/Mar/2008

Abstract:Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, said dermatological/cosmetic composition having physical stability without loss of viscosity over time at a temperature ranging from 4 DEG C. to 40 DEG C., said dermatological/cosmetic composition having a stable flow threshold over time as measured by viscosity measurements for rheograms which measure a shear stress tau for a given rate gradient gamma and which measure a rate gradient gamma for a given shear stress tau, the yield value (tau0) being extrapolated visually or by calculation.

Priority: FR20010016747 Applic. Date: 2001-12-21; US2002-326389 Applic. Date: 2002-12-23; US20020351382P Applic. Date: 2002-01-28

Inventor: ORSONI SANDRINE [FR]; WILLCOX NATHALIE [FR]


Application No.: US20080181974A1  Published: 31/Jul/2008

Title: Cosmetic composition containing an amber extract

Applicant/Assignee: LVMH RECHERCHE

Application No.: 11/888181   Filing Date: 31/Jul/2007

Abstract:The invention relates to a cosmetic composition comprising the following as active agents: a first active agent consisting of an amber extract, and at least one other cosmetically active agent selected from the group consisting of extracts of Bertholletia excelsa, extracts of Potentilla erecta, magnesium aspartate, peptides acting on muscle contraction, particularly acetyl hexapeptide 3, peptides and their derivatives grafted with a fatty acid, particularly a C16 fatty acid, promoting collagen synthesis, particularly palmitoyl oligopeptide pentapeptide 3 or palmitoyl tetrapeptide 7, soy flour hydrolyzates and plant glycolipids, particularly cereal glycosphingolipids and more particularly wheat glycosphingolipids. It further relates to the use of an amber extract as a cosmetic agent acting on the dermal supporting proteins and/or the enzymatic systems that degrade the dermal proteins and/or the glycan-type essential components of the extracellular matrix, particularly proteoglycans, for improving the essential biomechanical properties of the skin, namely firmness and elasticity, in the preparation of a cosmetic composition.

Priority: FR20070052973 Applic. Date: 2007-01-30

Inventor: CAUCHARD JEAN-HUBERT [FR]; BONTE FREDERIC [FR]; ARCHAMBAULT JEAN-CHRISTOPHE [FR]


Application No.: US20080182780A1  Published: 31/Jul/2008

Title: Method of Preventing or Reducing Scarring of Human Skin

Applicant/Assignee:

Application No.: 11/960327   Filing Date: 19/Dec/2007

Abstract:Insulin or a peroxisome proliferator-activated receptor (PPAR) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the PPAR agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring whilst enhancing re-epithelialisation of the wound and thus provides a dual action wound healing treatment. The present invention accordingly provides a highly effective prophylactic treatment for any individual suffering tissue trauma to reduce and/or prevent normal and/or pathological scarring.

Priority: GB20000029138 Applic. Date: 2000-11-29; WO2001GB05273 Applic. Date: 2001-11-29; US2002-239904 Applic. Date: 2002-09-26

Inventor: LINGE CLAIRE [GB]; MACKIE IAN PAUL [GB]


Application No.: US20080182787A1  Published: 31/Jul/2008

Title: AGENT AND COMPOSITIONS COMPRISING THE SAME FOR INHIBITING LIPASES AND PHOSPHOLIPASES IN BODY FLUIDS, CELLS AND TISSUES

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD

Application No.: 11/927923   Filing Date: 30/Oct/2007

Abstract:The present invention deals with a protein and compositions comprising the same for inhibition of lipases and phospholipases in the body fluids, cells, and tissues for the prevention and treatment of metabolic syndrome, cardiovascular disorders, and inflammatory diseases. The protein is either isolated from plant species or synthesized or produced by recombinant DNA technology.

Priority: US2005-093637 Applic. Date: 2005-03-30; US20040557624P Applic. Date: 2004-03-30

Inventor: UPADHYAY SHAKTI N [IN]; YADAV RAMAN P [IN]; ANSARI ARIF [IN]; RAO S HARINARAYANA [IN]


Application No.: US20080182894A1  Published: 31/Jul/2008

Title: METHOD OF PROVIDING PREPARATION FOR TOPICAL APPLICATION AND SUPPLEMENT MEETING CLIENT'S NEEDS

Applicant/Assignee: AJINOMOTO CO., INC

Application No.: 12/020791   Filing Date: 28/Jan/2008

Abstract:The present invention provides a method of efficiently providing, to a client, a preparation for topical application and a supplement suitable for the client. This method entails inputting the part desired by the client to be improved and an improvement effect desired for the part into a system, which will determine the composition of nutritional components of a preparation for topical application and a supplement that are suitable for the improvement effect desired for the part to be improved by referring to a database, in which compositions of nutritional components of supplements are registered in advance.

Priority: JP20050219669 Applic. Date: 2005-07-28; WO2006JP315446 Applic. Date: 2006-07-28

Inventor: TAKINO YOSHINOBU [JP]; SAGAWA KOICHIRO [JP]; AMINO YUSUKE [JP]


Application No.: US20080187575A1  Published: 07/Aug/2008

Title: Pyrimidine Derivatives

Applicant/Assignee:

Application No.: 11/661041   Filing Date: 29/Aug/2005

Abstract:The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above-mentioned diseases and disorders.

Priority: US20040604685P Applic. Date: 2004-08-27; WO2005EP09291 Applic. Date: 2005-08-29

Inventor: KLEBL BERT [DE]; BAUMANN MATTHIAS [DE]; HOPPE EDMUND [DE]; BREHMER DIRK [DE]; DAUB HENRIK [DE]; KERI GYORGY [HU]; VARGA ZOLTAN [HU]; MAROSFALVI JENO [HU]; ORFI LASZLO [HU]


Application No.: US20080187592A1  Published: 07/Aug/2008

Title: Cosmetic Composition Comprising A Tensioning Agent And A Hydroxyalkyl Urea

Applicant/Assignee: L'OREAL

Application No.: 11/720287   Filing Date: 22/Nov/2005

Abstract:The present invention relates to a cosmetic composition, in particular an anti-wrinkle composition, comprising, in a physiologically acceptable medium suitable for topical application to facial skin: (a) at least one tensioning agent chosen from: plant proteins and hydrolysates thereof, mixed silicates, colloidal particles of inorganic filler and synthetic polymers

and (b) at least one hydroxyalkyl urea of given formula. It also relates to the use of this hydroxyalkyl urea for improving the remanence of the tensioning effect afforded by a tensioning agent, and also to a process for treating wrinkled skin by applying to said skin a composition this hydroxyalkyl urea and a tensioning agent.

Priority: FR20040052768 Applic. Date: 2004-11-26; US20040634283P Applic. Date: 2004-12-09; WO2005EP14176 Applic. Date: 2005-11-22

Inventor: CASSIN GUILLAUME [FR]


Application No.: US20080187596A1  Published: 07/Aug/2008

Title: Benefit agent containing delivery particle

Applicant/Assignee:

Application No.: 12/077417   Filing Date: 18/Mar/2008

Abstract:The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.

Priority: US2005-145904 Applic. Date: 2005-06-06; US20040578761P Applic. Date: 2004-06-10; US20040620030P Applic. Date: 2004-10-19

Inventor: DIHORA JITEN ODHAVJI [US]; JAMES MARTIN IAN [IT]; SMETS JOHAN [BE]


Application No.: US20080188416A1  Published: 07/Aug/2008

Title: TISSUE FILLERS AND METHODS OF USING THE SAME

Applicant/Assignee: FREEDOM-2, INC

Application No.: 12/026457   Filing Date: 05/Feb/2008

Abstract:The invention relates to tissue filler compositions that are alterable or removable on demand. Also provided are methods for filling or augmenting tissue using the tissue fillers described herein, and correcting such tissue implants as required.

Priority: US20070888260P Applic. Date: 2007-02-05

Inventor: BERNSTEIN ERIC F [US]


Application No.: US20080188423A1  Published: 07/Aug/2008

Title: PI-3 KINASE INHIBITOR PRODRUGS

Applicant/Assignee: SEMAFORE PHARMACEUTICALS, INC

Application No.: 11/962612   Filing Date: 21/Dec/2007

Abstract:The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.

Priority: US2005-111201 Applic. Date: 2005-04-20; US2004-818145 Applic. Date: 2004-04-05; US20030460137P Applic. Date: 2003-04-03

Inventor: GARLICH JOSEPH R [US]; DURDEN DONALD L [US]; PATTERSON MARY [US]; SU JINGDONG [US]; SUHR ROBERT G [US]


Application No.: US20080188445A1  Published: 07/Aug/2008

Title: TETRACYCLINE COMPOSITIONS FOR TOPICAL ADMINISTRATION

Applicant/Assignee: WARNER CHILCOTT COMPANY INC

Application No.: 12/024794   Filing Date: 01/Feb/2008

Abstract:Multi-part pharmaceutical formulations containing tetracycline for topical administration, as well as methods of making and administering the same, are disclosed.

Priority: US20070887867P Applic. Date: 2007-02-02

Inventor: MULDOON BRENDAN [IE]; WOOLFSON DAVID [IE]; MCCULLAGH STEPHEN [IE]


Application No.: US20080188446A1  Published: 07/Aug/2008

Title: TETRACYCLINE COMPOSITIONS FOR TOPICAL ADMINISTRATION

Applicant/Assignee: WARNER CHILCOTT COMPANY INC

Application No.: 12/024723   Filing Date: 01/Feb/2008

Abstract:Pharmaceutical formulations containing tetracycline for topical administration, as well as methods of making and administering the same, are disclosed.

Priority: US20070887866P Applic. Date: 2007-02-02

Inventor: MULDOON BRENDAN [IE]; WOOLFSON DAVID [IE]; MCCULLAGH STEPHEN [IE]


Application No.: US20080188453A1  Published: 07/Aug/2008

Title: MAPK/ERK KINASE INHIBITORS

Applicant/Assignee:

Application No.: 11/932615   Filing Date: 31/Oct/2007

Abstract:Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Priority: US20060863748P Applic. Date: 2006-10-31

Inventor: ADAMS MARK E [US]; DONG QING [US]; KALDOR STEPHEN W [US]; KANOURI TOULIK [US]; WALLACE MICHAEL B [US]


Application No.: US20080188568A1  Published: 07/Aug/2008

Title: Increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages

Applicant/Assignee:

Application No.: 12/012647   Filing Date: 05/Feb/2008

Abstract:The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment

the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

Priority: US20070899433P Applic. Date: 2007-02-05

Inventor: SUVANPRAKORN PICHIT [TH]; VAYUMHASUWAN PANIDA [TH]; ZAIAS NARDO [US]


Application No.: US20080188846A1  Published: 07/Aug/2008

Title: Methods and Devices For the Non-Thermal, Electrically-Induced Closure of Blood Vessels

Applicant/Assignee:

Application No.: 11/663672   Filing Date: 20/Sep/2005

Abstract:Methods and devices for the non-thermal, electrically-induced temporary or permanent closure of blood vessels. The subject methods and devices employ pulsed electrical energy according to a defined regime to effect controlled occlusion of targeted blood vessels without heating the vessel and with minimal damage to adjacent tissue. The extent of vessel closure, i.e., temporary (vasoconstriction) or permanent (thrombosis), is controlled based on the manipulation of various parameters of the electrical stimulation regime as well as the configuration of the electrodes used to apply the regime.

Priority: US20040612835P Applic. Date: 2004-09-24; WO2005US33856 Applic. Date: 2005-09-20

Inventor: PALANKER DANIEL V [US]; VANKOV ALEXANDER B [US]


Application No.: US20080193385A1  Published: 14/Aug/2008

Title: COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY

Applicant/Assignee:

Application No.: 11/931076   Filing Date: 31/Oct/2007

Abstract:The present invention relates to compositions and methods for alleviating the painful symptoms due to neuropathy. Specifically, the method involves administering to a patient a composition comprising a nitric oxide donor that may be applied topically on the legs or arms to alleviate the negative effects due to neuropathy.

Priority: US20070900099P Applic. Date: 2007-02-08

Inventor: MAIBACH TODD [US]


Application No.: US20080193386A1  Published: 14/Aug/2008

Title: Compositions for Treating Alopecia or Promoting Hair Growth

Applicant/Assignee: MEDIGENES CO., LTD

Application No.: 11/909461   Filing Date: 24/Mar/2006

Abstract:The present invention relates to a composition for treating alopecia or promoting hair growth, which contains the blood plasma or serum as an active ingredient. The inventive composition is effective in hair growth, hair growth promotion and hair loss prevention.

Priority: KR20050024358 Applic. Date: 2005-03-24; WO2006KR01093 Applic. Date: 2006-03-24

Inventor: YOO WON-MIN [KR]; YOO NAE-CHOON [KR]; KEUM KI-CHANG [KR]; LEE SANG-YUP [KR]; LEE GENE [KR]


Application No.: US20080193393A1  Published: 14/Aug/2008

Title: Delivery System for Topically Applied Compounds

Applicant/Assignee: LIPO CHEMICALS INC

Application No.: 11/662996   Filing Date: 13/Sep/2005

Abstract:A delivery system for topically applied compounds is disclosed. The delivery system contains a fatty acid, a phospholipid, and an oil, and is activated by the addition of water. The delivery system is admixed with a topically applied compound and water to provide a composition suitable for application to the skin or hair. The relative amounts of delivery system ingredients provide round, flexible vesicles that allow penetration of the topically applied compound to the epidermis and dermis, vesicles having a partially ruptured membrane for a controlled delivery of the topically applied drug to the epidermis and dermis, completely ruptured vesicles in the form of lamellar sheets that allow the topically applied compound to be retained in the stratum corneum, and mixtures thereof.

Priority: US20040613034P Applic. Date: 2004-09-24; WO2005US32749 Applic. Date: 2005-09-13

Inventor: DAYAN NAVA [US]


Application No.: US20080193397A1  Published: 14/Aug/2008

Title: Use of Peroxide Decomposers Method For the Treatment of a Material Other Than the Human Body

Applicant/Assignee: BASF AKTIENGESELLSCAFT

Application No.: 11/914186   Filing Date: 12/May/2006

Abstract:The invention relates to the use of compounds with certain sulfur and optionally nitrogen atom-containing structures as peroxide decomposers in cosmetic and pharmaceutical agents for treating the skin. The invention also relates to cosmetic and pharmaceutical agents comprising compounds having such structures.

Priority: DE200510022292 Applic. Date: 2005-05-13; WO2006EP04487 Applic. Date: 2006-05-12

Inventor: KROLL MANFRED [DE]; WAGENBLAST GERHARD [DE]; PTOCK ARNE [DE]; HAREMZA SYLKE [DE]; JENTZSCH AXEL [DE]


Application No.: US20080193398A1  Published: 14/Aug/2008

Title: Derivatives of Heptaazaphenalene, Methods for Obtaining Them, and Their Use as Protecting Agents Against Uv Radiation

Applicant/Assignee: ISDIN, S.A

Application No.: 11/995489   Filing Date: 13/Jul/2006

Abstract:The present invention relates to new heptaazaphenalene derivatives of general Formula (I) and to methods for obtaining them. The physicochemical properties of said compounds allow them to be used as UV radiation absorbents.

Priority: ES20050001746 Applic. Date: 2005-07-13; WO2006EP64201 Applic. Date: 2006-07-13

Inventor: TRULLAS CARLES [ES]; PELEJERO CARLES [ES]; PANYELLA COSTA DAVID [ES]; CORBERA JORDI [ES]; HOLENZ JORG [ES]


Application No.: US20080193404A1  Published: 14/Aug/2008

Title: Isoalkane Mixture, Its Preparation And Use

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/913248   Filing Date: 11/May/2006

Abstract:The present invention relates to an isoalkane mixture, to a method for its preparation and to cosmetic or pharmaceutical compositions which comprise such a mixture.

Priority: DE200510022021 Applic. Date: 2005-05-12; WO2006EP04461 Applic. Date: 2006-05-11

Inventor: LANGE ARNO [DE]; ULONSKA ARMIN [DE]; WENDEL VOLKER [DE]


Application No.: US20080193449A1  Published: 14/Aug/2008

Title: Antibodies specific for DKK-1

Applicant/Assignee:

Application No.: 12/012885   Filing Date: 06/Feb/2008

Abstract:Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.

Priority: US20070900226P Applic. Date: 2007-02-08

Inventor: AN ZHIQIANG [US]; CHEN FANG [US]; FISHER JOHN E [US]; GLANTSCHNIG HELMUT [US]; KIMMEL DONALD B [US]; RESZKA ALFRED A [US]; WANG FUBAO [US]


Application No.: US20080193507A1  Published: 14/Aug/2008

Title: Wound Healing Profile

Applicant/Assignee:

Application No.: 10/589150   Filing Date: 14/Feb/2005

Abstract:The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterised by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.

Priority: GB20040003220 Applic. Date: 2004-02-13; GB20040003226 Applic. Date: 2004-02-13; GB20040026252 Applic. Date: 2004-11-30; US20040556194P Applic. Date: 2004-03-25; US20040556155P Applic. Date: 2004-03-25; US20040632425P Applic. Date: 2004-12-01; WO2005GB00511 Applic. Date: 2005-02-14

Inventor: KEMP PAUL [GB]; TALAS GYORGYI [GB]; SUTHERLAND JENNIFER [GB]; BATTEN MARGARET [GB]; JOHNSON PENELOPE ANN [GB]; SHERING ANDREW [GB]; MCWHAN MICHAEL [GB]


Application No.: US20080193517A1  Published: 14/Aug/2008

Title: Polymer Conjugates of K-252A and Derivatives Thereof

Applicant/Assignee: CREABILIS THERAPEUTICS S.P.A

Application No.: 12/064461   Filing Date: 25/Aug/2006

Abstract:The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. In a particular aspect, the invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system. In a further preferred aspect, the invention relates to the use of the polymer conjugates in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis. In a still further aspect, the invention relates to the use of the polymer conjugates in the prevention, alleviation and treatment of NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula (I).

Priority: US20050710890P Applic. Date: 2005-08-25; US20050720454P Applic. Date: 2005-09-27; US20060811469P Applic. Date: 2006-06-07; WO2006EP08374 Applic. Date: 2006-08-25

Inventor: TRAVERSA SILVIO [IT]; BAGNOD RAFFAELLA [IT]; BARONE DOMENICO [IT]; BERTARIONE RAVA ROSSA LUISA [IT]; FUMERO SILVANO [IT]; MAINERO VALENTINA [IT]; MARCONI ALESSANDRA [IT]; ODERDA CECILIA [CH]; PINCELLI CARLO [IT]; LORENZETTO CHIARA [IT]; BECCARIA LUCA [IT]


Application No.: US20080193569A1  Published: 14/Aug/2008

Title: Extraction Method for Producing Plant Extracts, Especially Waltheria Paniculata Extracts Containing Tiliroside

Applicant/Assignee:

Application No.: 11/909348   Filing Date: 27/Feb/2006

Abstract:The present invention relates to a process for the preparation of tiliroside or tiliroside-containing extracts from parts of a plant selected from the Sterculiaceae family, to corresponding extracts, and to the use of the extracts or process products in cosmetics or topical applications.

Priority: DE200510013380 Applic. Date: 2005-03-23; WO2006EP01799 Applic. Date: 2006-02-27

Inventor: WIRTH CORINNA [DE]; BUCHHOLZ HERWIG [DE]; ANDRADE DE SOUZA COSTA ALEXAND [BR]


Application No.: US20080194496A1  Published: 14/Aug/2008

Title: Skin Aging Treatment Comprising Paeoniflorin

Applicant/Assignee: LG HOUSEHOLD & HEALTH CARE LTD

Application No.: 11/571906   Filing Date: 10/May/2005

Abstract:The present invention relates to a skin aging treatment comprising paeoniflorin as an active ingredient. Since paeoniflorin is effective in significantly inhibiting and improving intrinsic skin aging, significantly inhibiting and improving DNA impairment and skin wrinkling caused by UV and improving existing wrinkles, a cosmetic composition and a pharmaceutical composition comprising paeoniflorin may become a very useful skin aging treatments.

Priority: KR20040032641 Applic. Date: 2004-05-10; KR20050018589 Applic. Date: 2005-03-07; KR20050035482 Applic. Date: 2005-04-28; WO2005KR01310 Applic. Date: 2005-05-10

Inventor: PARK HYOUNG-KOOK [KR]; LIM JUN-MAN [KR]; LEE SANG-HWA [KR]; KANG SANG-JIN [KR]; CHO WAN-GOO [KR]


Application No.: US20080194524A1  Published: 14/Aug/2008

Title: Compounds For the Inhibition of Undesired Cell Proliferation and Use Thereof

Applicant/Assignee: JERINI AG

Application No.: 10/583442   Filing Date: 18/Dec/2004

Abstract:The present invention is related to compounds having formula (I) wherein the dashed line indicates a single or double bond or is absent and wherein A<1>-A<9>, Q, R<1>-R<11>, T, U, V, W<1>-W<3>, X<1>, X<2>, Y and Z are as defined in the claims and description, pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament for the treatment of diseases involving abnormal cell proliferation, undesired cell proliferation, abnormal mitosis and/or undesired mitosis.

Priority: EP20030029450 Applic. Date: 2003-12-19; WO2004EP14460 Applic. Date: 2004-12-18

Inventor: KNOLLE JOCHEN [DE]; SCHUTKOWSKI MIKE [DE]; HUMMEL GERD [DE]; TRADLER THOMAS [DE]; JOBRON LAURENCE [DE]; CHRISTNER CLAUDIA [DE]; GIBSON CHRISTOPH [DE]; ZISCHINSKY GUNTHER [DE]


Application No.: US20080194528A1  Published: 14/Aug/2008

Title: Pharmaceutical compositions comprising organopolysiloxane elastomers and solubilized bioactive compounds

Applicant/Assignee: GALDERMA RESEARCH AND DEVELOPMENT

Application No.: 12/000773   Filing Date: 17/Dec/2007

Abstract:Stable, anhydrous pharmaceutical compositions contain an organopolysiloxane elastomer and, as bioactive ingredient, at least one vitamin D compound in a solubilized form, and are useful for the topical treatment of psoriasis and other skin disorders/afflictions.

Priority: FR20050006183 Applic. Date: 2005-06-17; WO2006FR01357 Applic. Date: 2006-06-15

Inventor: BARTHEZ NATHALIE [FR]; TONGLET EMILIE [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]


Application No.: US20080194541A1  Published: 14/Aug/2008

Title: Anti-Inflammatory Agents

Applicant/Assignee: CAMBRIDGE ENTERPRISE LIMITED

Application No.: 11/573637   Filing Date: 10/Aug/2005

Abstract:The invention provides compounds, compositions and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, which are 3-aminocaprolactam derivatives, for the preparation of a medicament intended to treat an inflammatory disorder wherein X is -CO-Y-(R<1>)n or SO2-Y-(R<1>)n

and Y is 0 cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group)

or is 0 cycloalkenyl or polycycloalkenyl group.

Priority: GB20040017863 Applic. Date: 2004-08-11; WO2005GB03133 Applic. Date: 2005-08-10

Inventor: GRAINGER DAVID J [GB]; FOX DAVID JOHN [GB]


Application No.: US20080194574A1  Published: 14/Aug/2008

Title: Pyrazine Derivatives As Effective Compounds Against Infectious Diseases

Applicant/Assignee: AXXIMA PHARMACEUTICALS AG

Application No.: 10/596508   Filing Date: 12/Dec/2006

Abstract:The present invention relates to pyrazine derivatives according to the general formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceutical compounds as well as the use of these compounds for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases, stroke and especially for the treatment of herpesviral induced infections, including opportunistic infections as well as infections and diseases caused by human cytomegalovirus (HCMV).

Priority: EP20030029038 Applic. Date: 2003-12-16; US20030530612P Applic. Date: 2003-12-19; WO2004EP14371 Applic. Date: 2004-12-16

Inventor: EIKHOFF JAN EIKE [DE]; ASHTON MARK RICHARD [GB]; COURTNEY STEPHEN MARTIN [GB]; YARNOLD CHRISTOPHER JOHN [GB]; VARRONE MAURIZIO [GB]; LOKE PUI LENG [GB]; HERGET THOMAS [DE]; SCHWAB WILFRIED [DE]; HAFENBRADL DORIS [DE]


Application No.: US20080194577A1  Published: 14/Aug/2008

Title: 2-Aminopyrimidine modulators of the histamine H4 receptor

Applicant/Assignee:

Application No.: 12/070051   Filing Date: 14/Feb/2008

Abstract:2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Priority: US20070889798P Applic. Date: 2007-02-14

Inventor: CAI HUI [US]; CHAVEZ FRANK [US]; EDWARDS JAMES P [US]; FITZGERALD ANNE E [US]; LIU JING [US]; MANI NEELAKANDHA S [US]; NEFF DANIELLE K [US]; RIZZOLIO MICHELE C [US]; SAVALL BRAD M [US]; SMITH DEBORAH M [US]; VENABLE JENNIFER D [US]; WEI JIANMEI [US]; WOLIN RONALD L [US]


Application No.: US20080194662A1  Published: 14/Aug/2008

Title: CLEANSER COMPOSITION

Applicant/Assignee:

Application No.: 11/674944   Filing Date: 14/Feb/2007

Abstract:A cleanser composition composed of purified water, sodium laureth sulfate, zinc pyrithione, cocamidopropyl betaine, glycerol cocoate, polyquaternium-7, and a cross-linked polyacrylic acid polymer for topical application to an area affected by a skin disorder such as seborrheic dermatitis, perioral dermatitis, rosacea, acne, tinea versicolor, eczema and psoriasis.

Priority:

Inventor: KUNIN AUDREY [US]


Application No.: US20080194664A1  Published: 14/Aug/2008

Title: Avermectin/metronidazole compositions for treating afflictions of the skin, e.g., rosacea

Applicant/Assignee: GALDERMA S.A

Application No.: 12/000182   Filing Date: 10/Dec/2007

Abstract:Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and metronidazole or salt, ester or derivative thereof, are useful for treating afflictions of the skin, especially rosacea.

Priority: FR20050005918 Applic. Date: 2005-06-10; WO2006FR01301 Applic. Date: 2006-06-08

Inventor: KAOUKHOV ALEXANDRE [FR]; PERNIN COLETTE [FR]


Application No.: US20080194699A1  Published: 14/Aug/2008

Title: Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof

Applicant/Assignee:

Application No.: 11/908531   Filing Date: 14/Mar/2006

Abstract:A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.

Priority: US2006-369305 Applic. Date: 2006-03-07; US20050751128P Applic. Date: 2005-12-16; US20050661356P Applic. Date: 2005-03-14; WO2006US09060 Applic. Date: 2006-03-14

Inventor: ALONSO ROBERT [US]; CROOKS PETER A [US]; PIMLEY MARK A [US]; LESSIN STUART R [US]; AL-GHANANEEM ABEER M [US]


Application No.: US20080195016A1  Published: 14/Aug/2008

Title: Multi-Ply Technical Composite Which Is Breathable And Moisturising, Releases Active Constituents And Promotes Their Absorption, And Can Be Uses As A Medical Aid Or To Make Clothing Or Structures That Come Into Direct Contact With Healthy Or Diseased Skin

Applicant/Assignee:

Application No.: 11/909211   Filing Date: 20/Mar/2006

Abstract:A multi-ply technical composite, usable in particular for making medical aids, garments and medical articles, includes at least two layers ( 2, 3 ), the first of which ( 2 ), in contact with the skin, is a cotton fabric (elasticised to a greater or lesser extent) or silk, or fabrics to which chitosan, silver or another antibacterial substance or active constituent is added, and the second, outer layer ( 3 ) is constituted by a semipermeable membrane, such as polyurethane between 5 and 80 microns thick, with considerable elasticity in order to ensure the user's comfort. Receptors rechargeable with active constituents are inserted into fabric ( 2 ) and protected by the polyurethane membrane.

Priority: IT2005MI00467 Applic. Date: 2005-03-22; WO2006IB00616 Applic. Date: 2006-03-20

Inventor: BOTTINI EMILIO [IT]


Application No.: US20080196113A1  Published: 14/Aug/2008

Title: Lipocalin Protein

Applicant/Assignee: ARES TRADING S.A

Application No.: 11/577266   Filing Date: 14/Oct/2005

Abstract:The invention is based on the discovery that the human protein referred to herein as INSP153 protein is a lipocalin.

Priority: GB20040022901 Applic. Date: 2004-10-14; WO2005GB03965 Applic. Date: 2005-10-14

Inventor: FITZGERALD STEPHEN NOEL [GB]; FAGAN RICHARD JOSEPH [GB]; POWER CHRISTINE [FR]; YORKE MELANIE [CH]


Application No.: US20080199411A1  Published: 21/Aug/2008

Title: Cosmetic Composition Comprising as Antiperspirant Agent a Flocculating Water-Soluble Polymer

Applicant/Assignee:

Application No.: 11/660371   Filing Date: 21/Jun/2005

Abstract:The invention relates to a cosmetic composition comprising at least one aqueous phase and at least one antiperspirant active agent, characterized in that the said antiperspirant active agent consists of at least one flocculating water-soluble polymer comprising amine groups on the main chain and in that it does not contain any aluminium and/or zirconium antiperspirant salts. The present invention also relates to a cosmetic process for treating perspiration, which consists in applying to the surface of the skin an effective amount of such a composition. The present invention also relates to the use of a flocculating water-soluble polymer comprising amine groups on the main chain as an antiperspirant active agent in a cosmetic composition, and in particular in a cosmetic composition not containing any aluminium and/or zirconium antiperspirant salts.

Priority: FR20040051867 Applic. Date: 2004-08-18; US20040613517P Applic. Date: 2004-09-28; WO2005EP07370 Applic. Date: 2005-06-21

Inventor: LEMOINE CYRIL [FR]; BEAU NATHALIE [FR]


Application No.: US20080199413A1  Published: 21/Aug/2008

Title: Novel Use of Organic Compounds

Applicant/Assignee:

Application No.: 11/995178   Filing Date: 13/Jul/2006

Abstract:The present invention is directed to the use of a compound selected from the group consisting of beta-carotene, lutein, lycopene and beta-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 for maintaining the energy metabolism, the energy flow and/or the energy production in skin or of skin of animals including humans, for maintaining the respiratory function of the skin of animals including humans, for energizing the skin, maintaining and supporting the radiance and natural glow of the skin of animals including humans and for promoting a healthy appearance of the skin of animals including humans for preventing UV-A radiation-induced mtDNA mutagenesis in skin of animals including humans, as well as for the manufacture of a composition, preferably an orally applicable composition, for these uses and the corresponding methods. The present invention is further directed to the use of a compound selected from the group consisting of beta-carotene, lutein, lycopene and beta-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 in sunscreens as well as daily care products to improve their photoprotective potential, as well as to their use as effective micronutrients for skin maintenance. Furthermore the present invention is directed to compositions, preferably orally applicable compositions, comprising a certain amount of at least one compound selected from the group consisting of beta-carotene, lutein, lycopene and beta-cryptoxanthin and mixtures thereof and combinations thereof with CoQ-10 as active ingredient, characterized in that the amount is effective for such uses as mentioned above.

Priority: EP20050015426 Applic. Date: 2005-07-15; EP20060008285 Applic. Date: 2006-04-21; WO2006EP06851 Applic. Date: 2006-07-13

Inventor: GORALCZYK REGINA [DE]; WERTZ KARIN [DE]


Application No.: US20080199512A1  Published: 21/Aug/2008

Title: Oral Composition For Moisturizing Skin

Applicant/Assignee:

Application No.: 12/065459   Filing Date: 30/Aug/2006

Abstract:Moisture of the skin, skin lipid balance and skin smoothness can be improved by administering an oral composition containing, as active ingredients, proteins and/or protein hydrolysates wherein the total proteins and hydrolysates contain at least 2 wt. % of cysteine residues. Preferably, the hydrolysates have an average molecular weight of between 200 and 4000 Dalton. The composition is administered in such an amount that between 25 and 500 mg of cysteine per day is supplied.

Priority: EP20050108057 Applic. Date: 2005-09-02; WO2006NL50211 Applic. Date: 2006-08-30

Inventor: DUDEK STEFFI [US]


Application No.: US20080200373A1  Published: 21/Aug/2008

Title: Multi-Component Biological Transport Systems

Applicant/Assignee:

Application No.: 10/591485   Filing Date: 03/Mar/2005

Abstract:Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternately, the compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

Priority: US2004-793138 Applic. Date: 2004-03-03; WO2005US06930 Applic. Date: 2005-03-03

Inventor: WAUGH JACOB M [US]; DAKE MICHAEL D [US]


Application No.: US20080200454A1  Published: 21/Aug/2008

Title: CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S

Applicant/Assignee:

Application No.: 12/031010   Filing Date: 14/Feb/2008

Abstract:Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Priority: US20070889977P Applic. Date: 2007-02-15

Inventor: AMERIKS MICHAEL K [US]; AXE FRANK U [US]; EDWARDS JAMES P [US]; GRICE CHERYL A [US]; CAI HUI [US]; GLEASON ELIZABETH ANN [US]; MEDUNA STEVEN P [US]; TAYS KEVIN L [US]; WIENER JOHN J M [US]; WICKBOLDT ALVAH T [US]


Application No.: US20080200783A1  Published: 26/Feb/2004

Title: Method and apparatus for control of skin perfusion for indirect glucose measurement

Applicant/Assignee: SENSYS MEDICAL, INC

Application No.: 10/384049   Filing Date: 07/Mar/2003

Abstract:A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion.

Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.

Priority: US2001-955531 Applic. Date: 2001-09-17; US2003-349573 Applic. Date: 2003-01-22; US20020363345P Applic. Date: 2002-03-08; US20000235369P Applic. Date: 2000-09-26

Inventor: BLANK THOMAS B [US]; RUCHTI TIMOTHY L [US]; MATTU MUTUA [US]; MAKAREWICZ MARCY [US]; MONFRE STEPHEN L [US]; LORENZ ALEXANDER D [US]


Application No.: US20080206153A1  Published: 28/Aug/2008

Title: Copolymers for Cosmetic Agents, Produced in the Presence of Polyfunctional Chain Transfer Agents

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/814448   Filing Date: 20/Jan/2006

Abstract:The present invention relates to cosmetic and pharmaceutical compositions which comprise a copolymer with anionogenic and/or anionic groups which is obtainable by free-radical polymerization of a monomer mixture in the presence of a polyfunctional regulator with at least three functional regulating groups. The invention further relates to a method of producing such a copolymer and to the copolymers obtainable by this method.

Priority: DE200510003010 Applic. Date: 2005-01-21; WO2006EP00516 Applic. Date: 2006-01-20

Inventor: WINTER GABI [DE]; CHRISSTOFFELS LYSANDER [DE]; WOOD CLAUDIA [DE]


Application No.: US20080206155A1  Published: 28/Aug/2008

Title: STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES

Applicant/Assignee: FOAMIX LTD

Application No.: 11/940290   Filing Date: 14/Nov/2007

Abstract:A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight

at least one multi-active agent

at a concentration of about 0.5% to about 15% by weight

water

an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition

and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition

wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents

wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators

(b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase

(c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase

(d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase

(e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion

(f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase

combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.

Priority: US20060858747P Applic. Date: 2006-11-14; US20070899176P Applic. Date: 2007-02-02

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]


Application No.: US20080206156A1  Published: 28/Aug/2008

Title: Continuous spray scalp therapy and dispensing systems for same

Applicant/Assignee:

Application No.: 11/677777   Filing Date: 22/Feb/2007

Abstract:The present invention relates to continuous spray medications involving the scalp, such as minoxidil, finesteride, copper peptides, DHT inhibitors and androgen receptor blockers, for example, in an amount sufficient to stimulate or maintain hair growth. The scalp medication is disposed within a pharmacologically acceptable carrier solution. In further embodiments, the spray scalp medication is dispensed within a product bag containing the medication in liquid form. The product bag is disposed within a container and includes a sheet of gas impervious material having a barrier layer therein. A gaseous propellant is also disposed within the container and is substantially separated from the medication. The valve assembly is selectively operated to produce a fine mist of said medication which is non-chilling, continuous and even.

Priority:

Inventor: CRONK PETER J [US]


Application No.: US20080206159A1  Published: 28/Aug/2008

Title: COMPOSITIONS WITH MODULATING AGENTS

Applicant/Assignee: FOAMIX LTD

Application No.: 11/947751   Filing Date: 29/Nov/2007

Abstract:The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.

Priority: US2004-835505 Applic. Date: 2004-04-28; US2006-430599 Applic. Date: 2006-05-09; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21; US20060861620P Applic. Date: 2006-11-29

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; BERMAN TAL [IL]; SCHUZ DAVID [IL]


Application No.: US20080206161A1  Published: 28/Aug/2008

Title: QUIESCENT FOAMABLE COMPOSITIONS, STEROIDS, KITS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/020381   Filing Date: 25/Jan/2008

Abstract:The present invention relates to an emulsion steroid composition as a foamable vehicle in which the vehicle is stable or stabilized by the presence of at least one quiesence agent

therapeutical kit containing such composition

to methods of treatment using such composition

to methods of enhancing the stability of such composition.

Priority: US20070897638P Applic. Date: 2007-01-26; US20030492385P Applic. Date: 2003-08-04; US2005-114410 Applic. Date: 2005-04-26; US2004-911367 Applic. Date: 2004-08-04; IL20020152486 Applic. Date: 2002-10-25

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]


Application No.: US20080206165A1  Published: 28/Aug/2008

Title: Single-use personal care products and kits comprising same

Applicant/Assignee:

Application No.: 12/001331   Filing Date: 11/Dec/2007

Abstract:Single-use personal care products and kits comprising the same are disclosed. At least some of the single-use products include a pre-measured amount of a shaving composition.

Priority: US20060874086P Applic. Date: 2006-12-11

Inventor: MITRA SHEKHAR [US]; GROH DAVID MATTHEW [US]; GUAY GORDON GERALD [US]


Application No.: US20080206169A1  Published: 28/Aug/2008

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/985383   Filing Date: 15/Nov/2007

Abstract:Personal care composition comprising at least one skin care active selected from the group consisting of acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tributyl citrate, acetyl triethyl citrate, acetyl tyrosine, adipic acid, alanine, arginine, arginine glutamate, benzophenone-3, camphor, gluconolactone, glucose, glycine, histidine hydrochloride, hydroxyproline, maltitol, phenylalanine, succinic acid, buffered lactic acid, tris(tetramethylhydroxypiperidinol) citrate, a boswellic acid compound, and salts, isomers, derivatives, and mixtures of any of the foregoing

and a dermatologically acceptable carrier.

Priority: US20060859361P Applic. Date: 2006-11-16

Inventor: MILLIKIN CHERI LYNN [US]; BISSETT DONALD LYNN [US]


Application No.: US20080206175A1  Published: 28/Aug/2008

Title: Composition for Skin Whitening and Wrinkle Improvement Comprising Vaccinium Uliginosum Extract and Method for Preparation Thereof

Applicant/Assignee:

Application No.: 11/813644   Filing Date: 11/Jan/2006

Abstract:The present invention relates to a composition for the skin whitening and wrinkle improvement, comprising an extract of Vaccinium uliginosum as an active ingredient. The Vaccinium uliginosum extract has the effects of inhibiting and scavenging reactive oxygen species produced in skin tissue as a result of ultraviolet irradiation to the skin, effectively inhibiting tyrosinase activity to inhibit the production of melanin in melanin cells, inhibiting the secretion of cytokines in keratinocytes, promoting the production of procollagen, and inhibiting the decomposition of collagen. Thus, the extract will be useful for the prevention of skin photo aging caused by ultraviolet radiation, the enhancement of skin whitening and the improvement of wrinkles. In addition, the Vaccinium uliginosum extract is suitable to use as a component for improving skin wrinkles in cosmetics, foods and drugs, because the Vaccinium uliginosum extract can achieve the effect of improving skin conditions, even when it is applied to the skin or used internally.

Priority: KR20050002473 Applic. Date: 2005-01-11; KR20050002474 Applic. Date: 2005-01-11; WO2006KR00108 Applic. Date: 2006-01-11

Inventor: CHUNG SE YOUNG [KR]


Application No.: US20080206222A1  Published: 28/Aug/2008

Title: Preventive/Therapeutic Composition For Free Radical Disease

Applicant/Assignee:

Application No.: 11/792520   Filing Date: 05/Aug/2005

Abstract:A preventive/therapeutic composition for free radical diseases, characterized by containing as an active ingredient at least one kind of a fullerene, a fullerene derivative, and a composite comprising a fullerene or fullerene derivative and an organic compound with which the fullerene or derivative has been modified or clathrated. The composition is reduced in side effects, has the high ability to eliminate free radicals in the body, and further has excellent preparation stability.

Priority: JP20040354271 Applic. Date: 2004-12-07; WO2005JP14798 Applic. Date: 2005-08-05

Inventor: MIWA NOBUHIKO [JP]; ITO SHINOBU [JP]; MATSUBAYASHI KENJI [JP]


Application No.: US20080206258A1  Published: 28/Aug/2008

Title: Novel Tetrahydropyridothiophenes

Applicant/Assignee: 4SC AG

Application No.: 11/920572   Filing Date: 24/May/2006

Abstract:Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Priority: EP20050104499 Applic. Date: 2005-05-25; EP20050112150 Applic. Date: 2005-12-14; WO2006EP62613 Applic. Date: 2006-05-24

Inventor: PEKARI KLAUS [DE]; SCHMIDT MATHIAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [DE]; GIMMNICH PETRA [DE]


Application No.: US20080206290A1  Published: 28/Aug/2008

Title: COSMETIC COMBINATION PRODUCT FOR IMPROVING APPEARANCE

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/839384   Filing Date: 15/Aug/2007

Abstract:A cosmetic combination product, wherein the product comprises at least two components selected from (a) one or more dietary supplements, (b) one or more cosmetic preparations for topical application to human skin, and (c) one or more patches for adhesion to human skin. Each of the selected components (a) to (c) comprises at least one cosmetically active substance which is also comprised in the other selected component(s). This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: DE200710009650 Applic. Date: 2007-02-26

Inventor: SCHULZ JENS [DE]; KROEPKE RAINER [DE]; SCHEPKY ANDREAS [DE]; ECKERT JULIA [DE]; KOOP URTE [DE]; FAENGER SABINE [DE]


Application No.: US20080206292A1  Published: 28/Aug/2008

Title: Cosmetic Method for Targeting of Wrinkles

Applicant/Assignee: L'OREL

Application No.: 11/994891   Filing Date: 04/Jul/2006

Abstract:A subject-matter of the invention is a cosmetic method for caring for wrinkled skin, for the purpose of softening the wrinkles, comprising the successive stages: (a) of topical application to the wrinkled areas of a first composition including a pulverulent phase comprising porous particles which comprise at least one antiwrinkle active principle at least partially absorbed in the said particles, the said composition being substantially devoid of solvent for the said active principle, and (b) of topical application to the skin of the face comprising at least the said areas of a second composition including a fatty and/or aqueous phase comprising a solvent for the said active principle.

Priority: FR20050053122 Applic. Date: 2005-10-14; WO2006IB03359 Applic. Date: 2006-07-04

Inventor: CASSIN GUILLAUME [FR]; SIMONNET JEAN-THIERRY [FR]


Application No.: US20080206293A1  Published: 28/Aug/2008

Title: Absorbent substrate with a non-leaching antimicrobial activity and a controlled-release bioactive agent.

Applicant/Assignee: QUICK-MED TECHNOLOGIES, INC UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC

Application No.: 12/036107   Filing Date: 22/Feb/2008

Abstract:This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such as doxycycline. The Wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents as well as bioactive agents. More generally, this invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymeric molecules and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.

Priority: WO2006US32953 Applic. Date: 2006-08-22; US2004-786959 Applic. Date: 2004-02-25; US20050710131P Applic. Date: 2005-08-22

Inventor: TOREKI WILLIAM [US]; LIESENFELD BERND [US]; MOORE DAVID [US]; SCHULTZ GREGORY [US]; OLDERMAN GERALD [US]; STAAB GREGORY [US]


Application No.: US20080206319A1  Published: 28/Aug/2008

Title: Hexosylceramides as Adjuvants and Their Uses in Pharmaceutical Compositions

Applicant/Assignee:

Application No.: 12/090279   Filing Date: 19/Oct/2006

Abstract:The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP20050022771 Applic. Date: 2005-10-19; WO2006EP10086 Applic. Date: 2006-10-19

Inventor: EBENSEN THOMAS [DE]; MORR MICHAEL [DE]; GUZMAN CARLOS A [DE]


Application No.: US20080206373A1  Published: 28/Aug/2008

Title: Personal Care Composition Comprising Botanical Extract

Applicant/Assignee:

Application No.: 12/039409   Filing Date: 28/Feb/2008

Abstract:Personal care composition comprising at least one extract selected from the group consisting of extracts of Terminalia bellerica, Butea monosperma, Mallotus philippinensis, Anogeissus latifolia, Innula racemosa, Ficus benghalensis, Nerium indicum, Psoralea corylifolia, Acacia catechu, Abies pindrow, Cedrus deodara, Emblica officinalis, Moringa oleifera, Glycyrrhiza glabra, and mixtures thereof, and a dermatologically acceptable carrier. Additionally or alternatively, the composition may comprise 2-hexyldecanol.

Priority: US20070904123P Applic. Date: 2007-02-28

Inventor: MILLIKIN CHERI LYNN [US]; GOODMAN LAURA JACKSON [US]; BISSETT DONALD LYNN [US]; ROBINSON LARRY RICHARD [US]; OSBORNE ROSEMARIE [US]


Application No.: US20080206378A1  Published: 28/Aug/2008

Title: Anthelmintic Composition

Applicant/Assignee:

Application No.: 11/813627   Filing Date: 19/Jan/2006

Abstract:A topical formulation comprising as active ingredients, at least one effective agent derived from Streptomyces avermitilis, i.e. a macrocylic lactone e.g. an avermectin or chemically modified or synthetic derivative thereof, e.g. ivermectin, together with another anthelmintic of the sulphonamide type, e.g. clorsulon, in a carrier that facilitates topical administration and delivery of the active ingredients transdermal Iy, e.g. a carrier that is useful for this purpose comprises alcoholic solvents, such as ethanol, and isopropanol, with optional excipients and formulation aids, which may comprise a polymeric species such as PVP or a poloxamer.

Priority: GB20050001220 Applic. Date: 2005-01-21; WO2006GB00211 Applic. Date: 2006-01-19

Inventor: BLAKELY WILLIAM [GB]; CROMIE LILLIAN [GB]


Application No.: US20080207545A1  Published: 28/Aug/2008

Title: Methods and Compositions for Treating 5Alpha-Reductase Type 1 and Type 2 Dependent Conditions

Applicant/Assignee:

Application No.: 11/885384   Filing Date: 20/Oct/2004

Abstract:The invention relates generally to the use of anti-sense oligonucleotides, small interfering RNA, and ribozymes to modulate expression of the human steroid 5alpha-reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders

Priority: US20030512689P Applic. Date: 2003-10-21; US20040545146P Applic. Date: 2004-02-18; WO2004US34510 Applic. Date: 2004-10-20

Inventor: HOKE GLENN D [US]; NIGRA THOMAS P [US]


Application No.: US20080207677A1  Published: 28/Aug/2008

Title: Napthyridine Compounds As Rock Inhibitors

Applicant/Assignee: GPC BIOTECH AG

Application No.: 11/813236   Filing Date: 02/Jan/2006

Abstract:The present invention relates to compounds having a naphthyridine scaffold, and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these naphthyridine derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said naphthyridine compounds have been identified as inhibitors of the protein kinase ROCK2, also known as Rho-kinase, and are useful for the treatment of cancers (tumor growth and metastases), erectile dysfunction, cardiovascular diseases, hypertension, angina pectoris, cerebral ischaemia, cerebral vasospasm, myocardial ischaemia, coronary vasospasm, heart failure, myocardial hypertrophy, atherosclerosis, restenosis, spinal cord injuries, neuronal degeneration, thrombotic disorders, asthma, glaucoma, inflammation, anti-viral diseases (e.g. HIV), and osteoporosis.

Priority: EP20040031078 Applic. Date: 2004-12-31; WO2006EP50005 Applic. Date: 2006-01-02

Inventor: MULLER STEFAN [DE]; SCHWAB WILFRIED [DE]; KLEBL BERT [DE]; HAFENBRADL DORIS [DE]; HOPPE EDMUND [DE]; HORVATH ZOLTAN [HU]; KERI GYORGY [HU]; VARGA ZOLTAN [HU]; ORFI LASZLO [HU]; MAROSFALVI JENO [HU]; MULLER GERHARD [DE]


Application No.: US20080207722A1  Published: 28/Aug/2008

Title: Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders

Applicant/Assignee: LABORATORIES SERONO SA

Application No.: 11/916097   Filing Date: 14/Jul/2006

Abstract:The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.

Priority: EP20050106547 Applic. Date: 2005-07-15; US20050706365P Applic. Date: 2005-08-08; WO2006EP64288 Applic. Date: 2006-07-14

Inventor: BOMBRUN AGNES [CH]; HOOFT VAN HUIJSDUIJNEN ROB [CH]; JORAND-LEBRUN CATHERINE [FR]; VITTE PIERRE-ALAIN [FR]; GERBER PATRICK [CH]


Application No.: US20080207725A1  Published: 28/Aug/2008

Title: Phenyl-Pyrazole Derivatives as Non-Steroidal Glucocorticoid Receptor Ligands

Applicant/Assignee: GLAXO GROUP LIMITED, A CORPORATION

Application No.: 11/917775   Filing Date: 27/Jun/2006

Abstract:A compound of formula (I): wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl

and R<1 >and R<2 >each independently represent hydrogen, fluorine or chlorine

or a physiologically functional derivative thereof.

Priority: GB20050013297 Applic. Date: 2005-06-29; WO2006EP06246 Applic. Date: 2006-06-27

Inventor: BARKER MICHAEL DAVID [GB]; HOUSE DAVID [GB]; JONES HAYDN TERENCE [GB]; MACDONALD SIMON JOHN FAWCETT [GB]; MCLAY IAIN MCFARLANE [GB]


Application No.: US20080207771A1  Published: 28/Aug/2008

Title: Topical Compositions

Applicant/Assignee: RESDEVCO RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 11/914429   Filing Date: 07/May/2006

Abstract:The present invention provides new topical pharmaceutical or cosmetic compositions for the prevention and treatment of irritation of mucous cells, or skin cells, comprising a combination of: xylitol, myoinositol or mannitol or any combination of these

glycerol and/or urea

water

in the absence of any oil in water or wax in water emulsion.

Priority: IL20050168603 Applic. Date: 2005-05-16; WO2006IL00537 Applic. Date: 2006-05-07

Inventor: DIKSTEIN SHABTAY [IL]


Application No.: US20080207774A1  Published: 28/Aug/2008

Title: ANIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/116040   Filing Date: 06/May/2008

Abstract:This invention relates to the field of polymeric materials that can be used in combination with a wide variety of substrates, such as personal care products, textiles, metal, cellulosic materials, plastics, and the like, and to the field of active agents including, for example, antimicrobial, antibacterial and antifungal materials. This invention further relates to latex polymer coatings that comprise at least one active component as well as methods for making and using such latex compositions.

Priority: US2007-895539 Applic. Date: 2007-08-24; US20060839892P Applic. Date: 2006-08-24

Inventor: KRISHNAN VENKATARAM [US]


Application No.: US20080207872A1  Published: 28/Aug/2008

Title: Polytetrafluoroethylene binding peptides and methods of use

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/607734   Filing Date: 01/Dec/2006

Abstract:Combinatorially generated peptides are provided that have binding affinity for Polytetrafluoroethylene (NY). The peptides may be used to deliver benefit agents to various PTFE surfaces.

Priority: US20050750726P Applic. Date: 2005-12-15

Inventor: CUNNINGHAM SCOTT D [US]; LOWE DAVID J [US]; O'BRIEN JOHN P [US]; WANG HONG [US]; WILKINS ANTOINETTE E [US]


Application No.: US20080208179A1  Published: 28/Aug/2008

Title: METHODS OF INCREASING SKIN PERMEABILITY BY TREATMENT WITH ELECTROMAGNETIC RADIATION

Applicant/Assignee: RELIANT TECHNOLOGIES, INC

Application No.: 11/925693   Filing Date: 26/Oct/2007

Abstract:Methods of treating tissue with fractional laser radiation are disclosed. The fractional laser treatment methods reversibly increase skin permeability while maintaining a substantially intact stratum corneum and producing alterations within the epidermis and dermis. The alterations in the epidermis and dermis can include necrosis and/or coagulation. The alterations in the epidermis can include the creation of a plurality of pores in the stratum corneum and/or the creation of vacuoles in the layers of the epidermis below the stratum corneum. The fractional laser treatment methods disclosed herein can be used to provide treatments to the skin, to increase permeation of active substances into or through tissue, to deliver active substances locally or systemically, and to control the delivery of active substances.

Priority: US20060863113P Applic. Date: 2006-10-26

Inventor: CHAN KIN F [US]; HANTASH BASIL M [US]; BEDI VIKRAMADITYA P [US]; FRANGINEAS GEORGE [US]


Application No.: US20080213179A1  Published: 04/Sep/2008

Title: Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions

Applicant/Assignee:

Application No.: 10/544991   Filing Date: 10/Feb/2004

Abstract:The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.

Priority: EP20030075390 Applic. Date: 2003-02-10; US20030446270P Applic. Date: 2003-02-11; US20030491522P Applic. Date: 2003-08-01; WO2004NL00092 Applic. Date: 2004-02-10

Inventor: GAILLARD PIETER JAAP [NL]; DE BOER ALBERTUS GERRIT [NL]; BRINK ARJEN [NL]


Application No.: US20080213191A1  Published: 04/Sep/2008

Title: Composition and/or articles comprising cyclodextrin complexing material

Applicant/Assignee:

Application No.: 11/712771   Filing Date: 01/Mar/2007

Abstract:Personal care products are provided. An exemplary personal care product includes a composition that is applied to the body or clothing, or an article applied against the body

a plurality of particles associated with the composition or a component of the article, the plurality of particles, at least some of the plurality of particles comprising a cyclodextrin complexing material and a first fragrance material, wherein the percent of the first fragrance material that is complexed with the cyclodextrin is greater than about 90%, so that the perceptibility of the first fragrance is minimized prior to its release

and a second fragrance material that is not complexed with the cyclodextrin and that is different from the first fragrance material, wherein the composition or article does not contain an antiperspirant active.

Priority:

Inventor: SCAVONE TIMOTHY ALAN [US]; LEBLANC MICHAEL JUDE [US]; SANKER LOWELL ALAN [US]; SWITZER ADRIAN GREGORY [US]


Application No.: US20080213198A1  Published: 04/Sep/2008

Title: Cosmetic or Dermopharmaceutical Composition Comprising at Least one Udp Glucuronosyl Transferase (Ugt) Enzymes Inducer

Applicant/Assignee: SEDERMA SAS

Application No.: 11/587533   Filing Date: 25/Apr/2005

Abstract:The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect and/or enhance the state of the skin and prevent and/or treat imperfections of the skin.

Priority: FR20040004408 Applic. Date: 2004-04-26; WO2005IB51344 Applic. Date: 2005-04-25

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]


Application No.: US20080213226A1  Published: 04/Sep/2008

Title: COMPOSITIONS INCLUDING AMMONIA OXIDIZING BACTERIA AND METHODS OF USING SAME

Applicant/Assignee:

Application No.: 12/060497   Filing Date: 01/Apr/2008

Abstract:A preparation and method for treating a subject how had developed or is at risk of developing at least one of high blood pressure, Alzheimer's Disease, obesity, and Diabetes Type II, Sickle Cell Anemia, Preeclampsia, Sudden Infant Death Syndrome, or Vascular disease comprising positioning ammonia oxidizing bacteria close proximity of a surface of the subject, of nitric oxide and nitric oxide precursors using ammonia oxidizing bacteria.

Priority: US2004-501415 Applic. Date: 2004-12-29; WO2003US00995 Applic. Date: 2003-01-13; US20020347760P Applic. Date: 2002-01-11; US20020375680P Applic. Date: 2002-04-26; US20020413667P Applic. Date: 2002-09-24

Inventor: WHITLOCK DAVID R [US]


Application No.: US20080213252A1  Published: 04/Sep/2008

Title: METHODS OF TREATING ITCH

Applicant/Assignee:

Application No.: 11/968800   Filing Date: 03/Jan/2008

Abstract:The invention provides methods for preventing and/or treating itch in a subject in need thereof by administration of a protease-activated G-protein coupled Protease Activated Receptor 4 (PAR4) antagonist. The PAR4 antagonist can be combined with a PAR2 antagonist.

Priority: US20070878302P Applic. Date: 2007-01-03

Inventor: LERNER ETHAN [US]; REDDY VEMURI B [US]


Application No.: US20080213374A1  Published: 04/Sep/2008

Title: NANOPARTICULATE SORAFENIB FORMULATIONS

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LIMITED

Application No.: 11/775002   Filing Date: 09/Jul/2007

Abstract:The present invention is directed to compositions comprising a nanoparticulate sorafenib, or a salt, such as a sorafenib tosylate, or derivative thereof, having improved bioavailability. The nanoparticulate sorafenib particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of cancer, renal cancer, and related diseases.

Priority: US20060819367P Applic. Date: 2006-07-10

Inventor: CARTY SARAH [IE]; JENKINS SCOTT [US]; LIVERSIDGE GARY [US]


Application No.: US20080213385A1  Published: 04/Sep/2008

Title: Formulations for 7- (T-Butoxy) Iminomethyl Camptothecin

Applicant/Assignee:

Application No.: 11/996638   Filing Date: 08/Aug/2006

Abstract:The present invention relates to nanoparticulate compositions in which the active agent is a topoisomerase I inhibitor and pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer.

Priority: US20050707190P Applic. Date: 2005-08-10; WO2006EP65159 Applic. Date: 2006-08-08

Inventor: KALB OSKAR [DE]; OTTINGER ISABEL [DE]; STEBLER WALTER [CH]; TAILLARDAT AGNES [CH]; WIRTH WOLFGANG [CH]


Application No.: US20080213451A1  Published: 04/Sep/2008

Title: Flavor Composition or Fragrance Composition, and Flavor-Improving Agents

Applicant/Assignee:

Application No.: 11/991806   Filing Date: 08/Sep/2006

Abstract:The present invention relates to a flavor composition or fragrance composition which can satisfy diversified requirements for flavored products, as well as to a flavor-improving agent which can improve the quality and release of aroma of a beverage or food. More particularly, the present invention relates to a flavor composition or fragrance composition which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, a flavor- or fragrance-added product, a flavor-improving agent which comprises an optically active S-alkyl 2-methylbutanethioate as an active ingredient, and a beverage or food having an improved flavor. The optically active S-alkyl 2-methylbutanethioate includes S-alkyl (R)-2-methylbutanethioate and S-alkyl (S)-2-methylbutanethioate.

Priority: JP20050263950 Applic. Date: 2005-09-12; JP20050263951 Applic. Date: 2005-09-12; WO2006JP317822 Applic. Date: 2006-09-08

Inventor: OGURA MIHARU [JP]; YAGUCHI YOSHIHIRO [JP]; EMURA MAKOTO [JP]; TAKEDA TOSHIHIRO [JP]; YUASA YOSHIFUMI [JP]; SASAKI SHIGEYUKI [JP]


Application No.: US20080214428A1  Published: 04/Sep/2008

Title: WASHING AND CLEANING AGENTS COMPRISING READILY SOLUBLE CAPSULES

Applicant/Assignee: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KG AA) HENKEL AG & CO. KGAA

Application No.: 12/028389   Filing Date: 08/Feb/2008

Abstract:Aqueous washing and cleaning agents that contain capsules in addition to other constituents, the capsules each encompassing an active ingredient in a matrix. The introduction of a combination of aluminum silicate and silicic acid into the matrix improves the solubility characteristics of the capsules in a washing operation.

Priority: DE200510038070 Applic. Date: 2005-08-10; WO2006EP07149 Applic. Date: 2006-07-20

Inventor: ORLICH BERNHARD [DE]; RICHTER BERND [DE]; HOLSKEN SOREN [DE]; VAN DER BURGH STEFAN [DE]


Application No.: US20080214615A1  Published: 04/Sep/2008

Title: N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same

Applicant/Assignee:

Application No.: 11/901291   Filing Date: 14/Sep/2007

Abstract:This invention relates to N-methylaminomethyl-isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US20060845227P Applic. Date: 2006-09-15

Inventor: MULLER GEORGE W [US]; CHEN ROGER SHEN-CHU [US]


Application No.: US20080214658A1  Published: 04/Sep/2008

Title: Composition Comprising Isoorientin for Suppressing Histamine

Applicant/Assignee: UNIGEN, INC

Application No.: 11/908927   Filing Date: 17/Mar/2006

Abstract:The present invention relates to a pharmaceutical composition for the prevention or treatment of diseases mediated by excessive histamine comprising naturally-derived isoorientin, a use of isoorientin for the manufacture of a medicament for the prevention or treatment of diseases mediated by excessive histamine, and a method for preventing or treating diseases mediated by excessive histamine comprising administering a therapeutically effective amount of isoorientin to a subject. The composition, use and method of the present invention show excellent histamine suppression effects, and so can be used for the prevention or treatment of various kinds of allergic disease, atopic disease, inflammatory disease, skin disease, hyperacidity and nervous system disorder.

Priority: KR20050022772 Applic. Date: 2005-03-18; WO2006KR00984 Applic. Date: 2006-03-17

Inventor: WOO SUNG-SICK [KR]; KIM DONG-SEON [KR]; DO SEON-GIL [KR]; LEE YOUNG-CHUL [KR]; OH MI-SUN [KR]; CHA JI-MIN [KR]; JO TAE-HYUNG [KR]


Application No.: US20080214669A1  Published: 04/Sep/2008

Title: Composition and Method For Treating Hyperpigmented Skin

Applicant/Assignee: LIPO CHEMICALS INC

Application No.: 11/793966   Filing Date: 20/Dec/2005

Abstract:An improved cosmetic and dermatological composition and a method for treating hyperpigmented skin is disclosed. The composition demonstrates an enhanced ability to lighten mammalian skin color, and is nontoxic and nonirritating. The composition comprises a hydroxycinnamic acid or a methoxycinnamic acid dissolved in a compound having one or more hydroxy groups, like a monoC1-4alkyl ether of an ethylene glycol or a monoC1-4alkyl ether of a propylene glycol oligomer, and/or a silicone fluid.

Priority: US20050643797P Applic. Date: 2005-01-14; US20050652303P Applic. Date: 2005-02-11; WO2005US46175 Applic. Date: 2005-12-20

Inventor: DAYAN NAVA [US]; RIEMER JED A [US]


Application No.: US20080214985A1  Published: 04/Sep/2008

Title: Active transdermal medicament patch

Applicant/Assignee: ACTIVATEK, INC

Application No.: 12/009409   Filing Date: 18/Jan/2008

Abstract:An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face. Each electrically conductively engages the skin, when the substrate is retained thereon. A power source carried on the substrate is electrically coupled between the medicament matrix and a programmed microprocessor also carried on the substrate. A substantially invariant voltage presented at an output contact of the microprocessor is applied during a predetermined therapy period across the skin between the medicament matrix and the return electrode, inducing transcutaneous migration of medicament into the skin at a substantially constant rate. A light-emitting diode carried on the substrate and coupled to the microprocessor communicates that the patch is operating.

Priority: US2007-701749 Applic. Date: 2007-02-02

Inventor: YANAKI JAMAL S [US]


Application No.: US20080219937A1  Published: 11/Sep/2008

Title: Use of at Least One 2-Alkyl Furan, as Depigmenting or Lightening Active Principle

Applicant/Assignee: LABORATOIRES EXPANSCIENCE

Application No.: 12/064878   Filing Date: 30/Aug/2006

Abstract:The invention concerns the cosmetic use of at least one 2-alkyl furan, as depigmenting active principle, in a depigmenting composition, as well as the associated cosmetic treatment method. The invention also concerns the use of at least one 2-alkyl furan for preparing an active drug as depigmenting agent. The invention further concerns a depigmenting cosmetic composition comprising as depigmenting active principle at least one 2-alkyl furan.

Priority: FR20050008866 Applic. Date: 2005-08-30; WO2006EP65836 Applic. Date: 2006-08-30

Inventor: MSIKA PHILIPPE [FR]; PICCARDI NATHALIE [FR]


Application No.: US20080219938A1  Published: 11/Sep/2008

Title: SPF compositions

Applicant/Assignee:

Application No.: 12/074906   Filing Date: 07/Mar/2008

Abstract:A composition comprising

water purified using ozonation, ionization, or distillation or any combination thereof wherein alcohol may be substituted for, or combined with water

at least one emollient including but not limited to chitosan, and aloe vera gel, individually or in any combination

an oil component with spf boosting agents including but not limited to

silicone oil and essential oils, butter milk, waxes impregnated with inorganic sun-block or sunscreen agent and organic/inorganic micronized particles, wood powder and bentonite clay, keratin, either individually or in any combination

at least one inorganic sun-block or sunscreen agent including any metal oxide, glass microsphere, silica and silica compound, and optionally metal oxide pigments with particles that are micronized, submicronized, nanoparticle sized, or otherwise individually or in any combination that can be homogenized in either a water phase, a water-aloe phase, or an oil phase or any phase of the composition

at least one emulsifier such that the emulsifier includes but is not limited to a phospholipid and/or liposome or an aloe vera gel or an ester of coconut oil individually or in any combination, for emulsification of the water, water-aloe, and/or the oil phases. Any of components are preferably mixed using an homogenizer and an appropriate thickening agent including but not limited to xanthan gum, and/or carageenan, either individually or in any combination that is added as required.

Priority: US20070905453P Applic. Date: 2007-03-07

Inventor: GRUNE GUERRY L [US]


Application No.: US20080219941A1  Published: 11/Sep/2008

Title: COMPOSITIONS AND METHODS FOR REMOVING HAIR STYLING AIDS

Applicant/Assignee:

Application No.: 11/683818   Filing Date: 08/Mar/2007

Abstract:Disclosed are compositions for solubilizing and/or removing a hair styling aid composition from hair. The compositions comprise at least one active solvent, wherein the active solvent is a glycol or an ester

and a carrier composition comprising a liquid vehicle. Also disclosed are methods for solubilizing and/or removing hair styling aids from hair.

Priority:

Inventor: DE LA GUARDIA MARIO M [US]; ADAIR TONY RAY [US]


Application No.: US20080220030A1  Published: 11/Sep/2008

Title: Nanoparticles Comprising Chitosan and Cyclodextrin

Applicant/Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

Application No.: 11/916283   Filing Date: 01/Jun/2006

Abstract:This invention relates to a system comprising nanoparticles designed for the release of biologically active molecules, where the nanoparticles comprise a) at least 40% by weight of chitosan or a derivative thereof and b) less than 60% by weight of a cyclodextrin or a derivative thereof, where both components a) and b) are mixed, without any covalent bond between them. This system allows for the efficient association of biologically active molecules, as well as their subsequent release in a suitable biological environment.

Priority: ES20050001331 Applic. Date: 2005-06-02; WO2006ES00322 Applic. Date: 2006-06-01

Inventor: ALONSO FERNANDEZ MA JOSE [ES]; FUENTES MARCOS GARCIA [ES]; MAESTRELLI FRANCESCA [ES]; MURA PAOLA [ES]


Application No.: US20080220031A1  Published: 11/Sep/2008

Title: Dermocosmetic Preparations

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/996424   Filing Date: 14/Jul/2006

Abstract:The present invention relates to dermocosmetic compositions comprising a compound comprising the structural element of the formula I where the radical Z has the following meaning: H, C1-C22alkyl group, C6-C10-aryl group, C1-C22-alkoxy group or a C6-C10-O-aryl group substituted by a C1-C22-alkyl or C-C22-alkoxy group, and the radicals R<1 >to R<6>, independently of one another, have the following meaning: H, C1-C22-alkyl group, C6-C10-aryl group, O, OH, C1-C22-alkoxy group or a C6-C10-O-aryl group substituted by a C1-C22-alkyl or C1-C22-alkoxy group, it being possible for R<5 >and R<6 >to be bridged in such a way that a five- to eight-membered ring is formed and, in the case of a five-membered ring, this ring may be part of an oligomer as a result of covalent bonds at positions 3 and 4. The invention furthermore relates to the use of said compounds in dermocosmetic formulations and the use of the dermocosmetics according to the invention for reducing skin or hair damage caused by free radicals. The invention furthermore relates to the use of the compounds according to the invention for increasing the stability of dermocosmetic formulations.

Priority: EP20050106825 Applic. Date: 2005-07-25; WO2006EP64264 Applic. Date: 2006-07-14

Inventor: WUNSCH THOMAS [DE]; HAREMZA SYLKE [DE]; JENTZSCH AXEL [DE]; WAGENBLAST GERHARD [DE]


Application No.: US20080220092A1  Published: 11/Sep/2008

Title: Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like

Applicant/Assignee: CHRONO THERAPEUTICS, INC

Application No.: 11/981672   Filing Date: 31/Oct/2007

Abstract:Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, plant extracts, botanicals, nutraceuticals, cosmeceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

Priority: US2005-162525 Applic. Date: 2005-09-13; US20060863686P Applic. Date: 2006-10-31; US20060863677P Applic. Date: 2006-10-31; US20060863671P Applic. Date: 2006-10-31; US20060863666P Applic. Date: 2006-10-31; US20060863654P Applic. Date: 2006-10-31; US20060863640P Applic. Date: 2006-10-31; US20060863618P Applic. Date: 2006-10-31; US20060863613P Applic. Date: 2006-10-31; US20060863608P Applic. Date: 2006-10-31; US20060863607P Applic. Date: 2006-10-31; US20040609418P Applic. Date: 2004-09-13

Inventor: DIPIERRO GUY [US]; GIANNOS STEVEN A [US]


Application No.: US20080221069A1  Published: 11/Sep/2008

Title: Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders

Applicant/Assignee: AUSPEX PHARMACEUTICALS, INC AUSPEX PHARMACEUTICALS

Application No.: 12/064552   Filing Date: 31/Aug/2006

Abstract:The present invention is directed to novel compounds according to formula (I) wherein R1, R2, and X are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

Priority: US20050713822P Applic. Date: 2005-09-02; WO2006US34380 Applic. Date: 2006-08-31

Inventor: SARSHAR SEPEHR [US]


Application No.: US20080221129A1  Published: 11/Sep/2008

Title: New compounds

Applicant/Assignee:

Application No.: 11/825431   Filing Date: 06/Jul/2007

Abstract:The present invention relates to compounds of the formula (I): including pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers, and N-oxides thereof, said compounds being useful as inhibitors of stearoyl-CoA desaturase (SCD). The invention further relates to the use of compounds of the formula (I) for treatment of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, neurological diseases, immune disorders, cancer, essential fatty acid deficiency, acne, psoriasis, rosacea or other skin conditions.

Priority: SE20060001511 Applic. Date: 2006-07-07; US20060860677P Applic. Date: 2006-11-21

Inventor: LUNDBACK THOMAS [SE]; CLIMENT-JOHANSSON ISABEL [SE]; VAGBERG JAN [SE]; LINDEN AURI [SE]; NILSSON JONAS [SE]; WIIK MARIE [SE]; BREMBERG ULF [SE]


Application No.: US20080221189A1  Published: 11/Sep/2008

Title: Use of Metronidazole For Preparing a Pharmaceutical Composition For Treating Pathologies Related to the B-Type Receptor of Interleukin 8 and/or to a Pacap Type 1 Receptor

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 10/590031   Filing Date: 17/Feb/2005

Abstract:The invention relates to use of metronidazole for the preparation of a pharmaceutical composition for treating pathologies involving at least one receptor chosen from the group comprising the IL-8RB receptor and the PAC-1 receptor.

Priority: FR20040001721 Applic. Date: 2004-02-20; WO2005FR00370 Applic. Date: 2005-02-17

Inventor: DOLFI FABRIZIO [FR]; SAFONOVA IRINA [FR]


Application No.: US20080226570A1  Published: 18/Sep/2008

Title: Cosmetic Treatment for Body-Modelling with Sun Protection and Modelling Kit

Applicant/Assignee: COTY PRESTIGE LANCASTER GROUP GMBH

Application No.: 11/912638   Filing Date: 04/May/2006

Abstract:The invention relates to a method for body shaping by means of a sun-protection agent and a corresponding cosmetic product. The inventive method consists in pre-treating by means of a preliminary product containing a caffeine, algae extract, pineapple extract, radical scavenger, copper gluconate, silylpropionic acid and a melanin-stimulating amino acid-containing agent, in subsequently treating by a main product containing, apart from an UVA- and UVB-Filter, at an ratio ranging from 30:70 to 70:30, a green coffee bean oil whose radical scavenger content is 30-60% less than this of the preliminary agent and in post-treating by means of an after-product which comprises the preliminary product constituents and whose silylpropionic acid content is of 2 to 10 times the content of the preliminary product.

Priority: DE200510021805 Applic. Date: 2005-05-04; WO2006EP62039 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Application No.: US20080226571A1  Published: 18/Sep/2008

Title: Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin

Applicant/Assignee:

Application No.: 11/687039   Filing Date: 16/Mar/2007

Abstract:A composition based on labdane-diterpenoids that provides better photo protection against both UV A and UV B radiations in the HaCaT human keratinocyte cell lines is disclosed. The composition comprises 8,13-epoxy-1alpha,6beta,7beta,9alpha-tetrahydroxylabd-14-en-11-one alone and in combination with 6beta-acetoxy-8,13-epoxy-1alpha,7beta,9alpha-trihydroxylabd-14-en-11-one and/or 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one. The composition protects the cells of the skin from harmful UV A and UV B rays through synergistic mechanisms with utility as a safe long-term cosmetic solution for preventing UV-induced skin damage and to induce sunless tanning. Additionally, the composition enhances melanogenesis in B16F1 mouse melanoma cells acting as tanning inducers/accelerators both in the presence or absence of sunlight. Elevation of melanogenesis confers additional protection against UV-induced skin damage.

Priority:

Inventor: MAJEED MUHAMMED [US]


Application No.: US20080226640A1  Published: 18/Sep/2008

Title: C1q Related Protein

Applicant/Assignee: ARES TRADING S.A

Application No.: 11/718204   Filing Date: 28/Oct/2005

Abstract:This invention relates to a novel protein, termed INSP162, herein identified as a secreted protein containing c1q and collagen domains and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.

Priority: GB20040023973 Applic. Date: 2004-10-28; WO2005GB04193 Applic. Date: 2005-10-28

Inventor: FITZGERALD STEPHEN [GB]; FASAN RICHARD JOSEPH [GB]


Application No.: US20080226684A1  Published: 18/Sep/2008

Title: METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 12/047309   Filing Date: 12/Mar/2008

Abstract:The present invention includes compositions, methods, systems and kits for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Priority: US20070894451P Applic. Date: 2007-03-12

Inventor: PEPPAS NICHOLAS A [US]


Application No.: US20080226699A1  Published: 18/Sep/2008

Title: Method and System for Rapid Transdermal Administration

Applicant/Assignee: ACRUX DDS PTY LTD

Application No.: 10/580845   Filing Date: 26/Nov/2004

Abstract:Invention relates to a method for transdermal delivery of a topically applied physiologically active agent comprising: providing a micro-projection apparatus comprising an array of microprojections ( 3 ) extending from a substrate

applying the array of micro-projections to an area of skin to form an array of microscopic holes therein

and contacting the area of skin with a transdermal composition comprising a physiologically active agent and at least one penetration enhancer wherein the formation of the microscopic holes and penetration enhancer facilitate transdermal delivery of the physiologically active agent.

Priority: AU20030906631 Applic. Date: 2003-11-28; WO2004AU01666 Applic. Date: 2004-11-26

Inventor: FINNIN BARRIE CHARLES [AU]; MORGAN TIMOTHY MATTHIAS [AU]; WILKINS NINA FRANCES [AU]; KNORK CHEW NORA YAT [AU]; GONDA IGOR [AU]


Application No.: US20080226706A1  Published: 18/Sep/2008

Title: Use of Repeat Sequence Protein Polymers in Personal Care Compositions

Applicant/Assignee:

Application No.: 12/062305   Filing Date: 03/Apr/2008

Abstract:The present invention provides personal care compositions, and more particularly, personal care compositions comprising a bioactively effective amount of a repeat sequence protein polymer. In some particularly preferred embodiments, the present invention provides personal care compositions comprising an effective amount of at least one fragment of a repeat sequence protein polymer having bioactivity.

Priority: US2004-939036 Applic. Date: 2004-09-10; US2004-800179 Applic. Date: 2004-03-12; US20030454077P Applic. Date: 2003-03-12

Inventor: KUMAR MANOJ [US]


Application No.: US20080226708A1  Published: 18/Sep/2008

Title: Silicone Vesicles Containing Actives

Applicant/Assignee:

Application No.: 12/091185   Filing Date: 25/Oct/2006

Abstract:Processes are disclosed for preparing silicone vesicle compositions and emulsions containing silicone vesicles, the compositions prepared therefrom, and formulated personal and healthcare products containing the silicone vesicles and emulsions compositions.

Priority: US20050732392P Applic. Date: 2005-11-01; US20050732841P Applic. Date: 2005-11-02; WO2006US41831 Applic. Date: 2006-10-25

Inventor: LIN SHAOW BURN [US]; THOMPSON JAMES [US]; NEWTON JOANNA [BE]; POSTIAUX STEPHANIE [BE]


Application No.: US20080226720A1  Published: 18/Sep/2008

Title: Wound Healing Composition

Applicant/Assignee:

Application No.: 10/589227   Filing Date: 14/Feb/2005

Abstract:The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.

Priority: GB20040003220 Applic. Date: 2004-02-13; GB20040003226 Applic. Date: 2004-02-13; GB20040026252 Applic. Date: 2004-11-30; US20040556194P Applic. Date: 2004-03-25; US20040556155P Applic. Date: 2004-03-25; US20040632425P Applic. Date: 2004-12-01; WO2005GB00523 Applic. Date: 2005-02-14

Inventor: KEMP PAUL [GB]; TALAS GYORGYI [GB]; SUTHERLAND JENNIFER [GB]; BATTEN MARGARET [GB]; JOHNSON PENELOPE ANN [GB]; SHERING ANDREW [GB]; MCWHAN MICHAEL [GB]


Application No.: US20080226723A1  Published: 18/Sep/2008

Title: Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same

Applicant/Assignee: CELONOVA BIOSCIENCES, INC

Application No.: 11/931685   Filing Date: 31/Oct/2007

Abstract:Particles are provided for use in restorative procedures to treat erectile dysfunction. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be loaded to provide localized treatment with an active agent directed at restoration of normal penile erectile function and the treatment of erectile dysfunction. Moreover, such particles may be provided to a user with customized coloration or in various coded colors to indicate differing doses of active agent contained therein.

Priority: DE20021030190 Applic. Date: 2002-07-05; WO2003EP07197 Applic. Date: 2003-07-04; US2004-023928 Applic. Date: 2004-12-28

Inventor: FRITZ OLAF [DE]; FRITZ ULF [DE]; WOJCIK RONALD [US]; GASKINS RALPH E [US]


Application No.: US20080226728A1  Published: 18/Sep/2008

Title: Antimicrobial Nanoparticulate Additives Forming Non-Leachable Sustained Antimicrobial Polymeric Compositions

Applicant/Assignee:

Application No.: 11/794492   Filing Date: 01/Jan/2006

Abstract:The present invention provides a particle comprising at least one aliphatic polymer having anti-microbially active quaternary ammonium groups chemically bound thereto. The particle of the invention may be used to inhibit populations of microorganisms and biofilms. Also provided are methods for the preparation of such particles and uses thereof for the inhibition of microorganisms.

Priority: US20040639966P Applic. Date: 2004-12-30; WO2006IL00005 Applic. Date: 2006-01-01

Inventor: DOMB ABRAHAM J [IL]; WEISS ERVIN [IL]; BEYTH NURIT [IL]; FARBER IRA [IL]; DAVIDI MICHAEL PEREZ [IL]


Application No.: US20080227704A1  Published: 18/Sep/2008

Title: CXCL13 binding proteins

Applicant/Assignee:

Application No.: 12/004677   Filing Date: 20/Dec/2007

Abstract:The present invention encompasses CXCL13 binding proteins. Specifically, the invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for CXCL13 and CXCL13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting mouse CXCL13 and for inhibiting mouse CXCL13 activity, e.g., in a mammal suffering from a disorder in which CXCL13 activity is detrimental.

Priority: US20060876375P Applic. Date: 2006-12-21

Inventor: KAMENS JOANNE S [US]


Application No.: US20080227724A1  Published: 18/Sep/2008

Title: Anti-Inflammatory Agents

Applicant/Assignee: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED

Application No.: 10/581274   Filing Date: 30/Nov/2004

Abstract:The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof

wherein X is -CO-R<1 >or -SO2-R<2>, and R<1 >and R<2 >are carbonaceous substituents.

Priority: GB20030027775 Applic. Date: 2003-12-01; GB20040017436 Applic. Date: 2004-08-05; GB20040017734 Applic. Date: 2004-08-10; WO2004GB05030 Applic. Date: 2004-11-30

Inventor: GRAINGER DAVID JOHN [GB]; FOX DAVID JOHN [GB]


Application No.: US20080227842A1  Published: 18/Sep/2008

Title: Non-fluorescent chlorophyll catabolites

Applicant/Assignee: LEOPOLD-FRANZENS-UNIVERSITAT INNSBRUCK

Application No.: 12/073888   Filing Date: 11/Mar/2008

Abstract:The invention relates to a compound of formula (I), or a pharmacologically or cosmetically acceptable salt or derivative thereof, wherein R1 to R5 are selected from the groups R1 representing -alkyl, -vinyl, -CHOH-CH2OH, R2 representing H, -OH, -Oalkyl, -Oacyl, saccharide groups, modified saccharide groups (e.g. malonylated), R3 representing -H, -OH, -Oalkyl, -Oacyl, modified -Oacyl (e.g. malonylated), saccharide groups, modified saccharide groups (e.g. malonylated), R4, R5 representing -COOH, -carbonic esters, for use as drug, antioxidant, food supplement. The invention also relates to a method for producing the compound of formula (I).

Priority: AT20050001488 Applic. Date: 2005-09-12; WO2006AT00370 Applic. Date: 2006-09-06

Inventor: KRAUTLER BERNHARD [AT]; MULLER THOMAS [AT]


Application No.: US20080228151A1  Published: 18/Sep/2008

Title: Transdermal drug delivery with controlled heat for treating musculoskeletal pain and/or inflammation

Applicant/Assignee:

Application No.: 12/074259   Filing Date: 28/Feb/2008

Abstract:Systems and methods for transdermal drug delivery with controlled heat are provided. Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover. The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. In some embodiments, the heating apparatus can include more than one heating element. The systems can further include a drug-containing layer that includes a drug. The drug-containing layer can have a surface area of about 50 cm<2 >to about 400 cm<2>. The systems of the present invention can be deliver ketoprofen in an amount sufficient to produce a mean blood plasma concentration of ketoprofen in a human subject of at least 45 ng/ml within four hours after initial application of the system to a skin surface.

Priority: US20070904208P Applic. Date: 2007-02-28

Inventor: ZHANG JIE [US]; WARNER KEVIN S [US]; NELSON RANDAL [US]; VAWDREY ALAN [US]; STRONG NATHAN [US]; NIU SUYI [US]; WESSMAN MICHAEL D [US]; IVERSON MATTHEW [US]


Application No.: US20080228456A1  Published: 18/Sep/2008

Title: MODELING WOUND HEALING

Applicant/Assignee:

Application No.: 11/869852   Filing Date: 10/Oct/2007

Abstract:Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.

Priority: US20060850690P Applic. Date: 2006-10-10; US20060850896P Applic. Date: 2006-10-11

Inventor: CLERMONT GILLES [US]; HEBDA PATRICIA A [US]; LI YEE KEY [US]; MI QI [US]; STEED DAVID L [US]; SULLIVAN JOSHUA THOMAS [US]; ABBOTT KATHERINE VERDOLINI [US]; VODOVOTZ YORAM [US]; YOTOV IVAN PETROV [US]; AN GARY [US]


Application No.: US20080233062A1  Published: 25/Sep/2008

Title: CATIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/116006   Filing Date: 06/May/2008

Abstract:This invention relates to the field of polymeric materials that can be used in combination with a wide variety of substrates, such as textiles, metal, cellulosic materials, plastics, and the like, and to the field of active agents including, for example, antimicrobial, antibacterial, and antifungal materials. This invention further relates to latex polymer coatings that comprise at least one active component as well as methods for making and using such latex compositions.

Priority: US2007-895541 Applic. Date: 2007-08-24; US20060839973P Applic. Date: 2006-08-24

Inventor: KRISHNAN VENKATARAM [US]


Application No.: US20080233177A1  Published: 25/Sep/2008

Title: Fibre-Free Transdermal Therapeutic System and Method For Its Production

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 11/885716   Filing Date: 28/Feb/2006

Abstract:A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.

Priority: DE200510010255 Applic. Date: 2005-03-07; WO2006EP01840 Applic. Date: 2006-02-28

Inventor: MECONI REINHOLD [DE]


Application No.: US20080234194A1  Published: 25/Sep/2008

Title: GROWTH FACTOR MEDIATED COSMECEUTICALS AND USE THEREOF TO ENHANCE SKIN QUALITY

Applicant/Assignee:

Application No.: 12/052672   Filing Date: 20/Mar/2008

Abstract:It has been discovered that vascular endothelial growth factor ("VEGF") promotes migration of activated (but not differentiating) keratinocytes to skin. This growth factor specifically increases migration of keratinocytes of the "wounded skin" phenotype but does not have significant effects upon differentiated keratinocytes. It also increases collagen deposition and reduces wrinkles, enhances skin quality, and increases skin thickness to normal levels in individuals where skin has thinned due to age or disorder such as diabetes. It is particularly well suited for use as cosmeceuticals when applied in purified form and in known amounts. The data presented in the examples demonstrate efficacy and specificity of VEGF in enhancing migration of normal human keratinocytes as well as formation of new granulation tissue including collagen formation. VEGF induces keratinocyte and fibroblast migration, formation of new tissue, and not only induces deposition of collagen but improves alignment of the collagen fibers. Accordingly, this growth factor is highly suitable for use as a cosmeceutical, especially for skin resurfacing and reduction in wrinkles.

Priority: US20070895942P Applic. Date: 2007-03-20

Inventor: BREM HAROLD [US]; TOMIC MARJANA [US]


Application No.: US20080234195A1  Published: 25/Sep/2008

Title: THERAPEUTIC, NUTRACEUTICAL AND COSMETIC APPLICATIONS FOR EGGSHELL MEMBRANE AND PROCESSED EGGSHELL MEMBRANE PREPARATIONS

Applicant/Assignee: NEW LIFE RESOURCES, LLC

Application No.: 12/060498   Filing Date: 01/Apr/2008

Abstract:The present invention relates to therapeutic, cosmetic, and nutraceutical applications for eggshell membrane, processed eggshell membrane preparations and eggshell membrane isolates. The invention is directed to treating a mammal that will benefit from the administration of naturally occurring material found in eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof by administering to the mammal a composition containing eggshell membrane, processed eggshell membrane, eggshell membrane isolates and combinations thereof, alone or in combination with other active ingredients.

Priority: US2007-943169 Applic. Date: 2007-11-20; US2004-797747 Applic. Date: 2004-03-10; US20030453891P Applic. Date: 2003-03-12; US20030488538P Applic. Date: 2003-07-18; US20030501364P Applic. Date: 2003-09-09

Inventor: LONG FRANK DANIEL [US]; ADAMS RANDALL GENE [US]; DEVORE DALE PAUL [US]; FRANKLIN MARSHALL ROBERT [US]


Application No.: US20080234241A1  Published: 25/Sep/2008

Title: MELANOGENESIS INHIBITORS AND WHITENING AGENTS COMPRISING ERGOSTEROL DERIVATIVE AND COMPOSITIONS CONTAINING ERGOSTEROL DERIVATIVE

Applicant/Assignee: SAKAMOTO BIO CO., LTD

Application No.: 12/128137   Filing Date: 28/May/2008

Abstract:It is intended to provide a substance which is efficacious in whitening sun-burnt skin after UV irradiation and preventing, ameliorating and treating skin pigmentation (for example, spots and freckles caused by sunburn, liver spots) and compositions containing the same. Melanogenesis inhibitors and whitening agents comprising an ergosterol derivative represented by formula (1)

melanogenesis inhibitors and whitening agents containing the ergosterol derivative represented by the formula (1)

melanogenesis inhibitory compositions and whitening compositions containing the ergosterol derivative represented by formula (1)

cosmetics, drugs and external skin preparations containing the ergosterol derivative represented by formula (1)

and melanogenesis inhibitory foods and whitening foods containing the ergosterol derivative represented by formula (1).

Priority: JP20000310290 Applic. Date: 2000-10-11; US2003-399029 Applic. Date: 2003-04-11; WO2001JP08892 Applic. Date: 2001-10-10

Inventor: SAKAMOTO KENJI [JP]; HATA KEISHI [JP]


Application No.: US20080234285A1  Published: 25/Sep/2008

Title: Combination of Organic Compounds

Applicant/Assignee:

Application No.: 10/586013   Filing Date: 21/Jan/2005

Abstract:The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising the renin inhibitor of formula (I) or a pharmaceutically acceptable salt thereof and at least one PDGF receptor tyrosine kinase inhibitor.

Priority: US20040583222P Applic. Date: 2004-06-25; WO2005EP00597 Applic. Date: 2005-01-21

Inventor: FELDMAN DAVID LOUIS [US]


Application No.: US20080234301A1  Published: 25/Sep/2008

Title: Alpha-4 Integrin Mediated Cell Adhesion Inhibitors for the Treatment or Prevention of Inflammatory Diseases

Applicant/Assignee:

Application No.: 10/588235   Filing Date: 08/Feb/2005

Abstract:The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

Priority: GB20040002812 Applic. Date: 2004-02-09; WO2005JP02194 Applic. Date: 2005-02-08

Inventor: WARD ROBERT WILLIAM [GB]; WITHERINGTON JASON [GB]


Application No.: US20080241078A1  Published: 02/Oct/2008

Title: COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING C16-C20 AROMATIC TETRAHYDRO PROSTAGLANDINS

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 12/138733   Filing Date: 13/Jun/2008

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2006-565297 Applic. Date: 2006-11-30; US2001-774555 Applic. Date: 2001-01-31; US20000193846P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL ANTHONY [US]; MCIVER JOHN MCMILLAN [US]; YOUNGQUIST ROBERT SCOTT [US]


Application No.: US20080241079A1  Published: 02/Oct/2008

Title: Skin Care Products

Applicant/Assignee: NEUBOURG SKIN CARE GMBH & CO. KG

Application No.: 12/088599   Filing Date: 21/Jul/2006

Abstract:The invention relates to a formulation comprising an aqueous emulsion and a propellant gas for a foam skin cream, wherein the emulsion comprises urea and hyaluronic acid, at least one free fatty acid and at least two emulsifiers, wherein the hyaluronic acid has a molecular weight of at least 1x10<5 >Da.

Priority: DE200520015309U Applic. Date: 2005-09-28; DE200620004676U Applic. Date: 2006-03-23; US20050721170P Applic. Date: 2005-09-28; US20060785391P Applic. Date: 2006-03-23; WO2006EP64533 Applic. Date: 2006-07-21

Inventor: NEUBOURG THOMAS [DE]


Application No.: US20080241082A1  Published: 02/Oct/2008

Title: Method for the Preparation of Cosmetic Emulsion

Applicant/Assignee: LONZA INC

Application No.: 10/596116   Filing Date: 04/Mar/2008

Abstract:A novel method is disclosed for the preparation of oil-in-water emulsions suitable for cosmetic or topical dermatological products. The method comprises the step of mixing at least one cosmetically active ingredient with an aqueous emulsion of washed vegetable oil bodies (oleosomes) and the temperature of the products does never exceed about 40 DEG C. during the steps of the method.

Priority: EP20040016057 Applic. Date: 2004-07-08; US20040559832P Applic. Date: 2004-04-05; WO2005EP03501 Applic. Date: 2005-04-04

Inventor: GUTH JACOB [US]; LENTNER VICKIE [US]


Application No.: US20080241088A1  Published: 02/Oct/2008

Title: ANTIPERSPIRANT/DEODORANT COMPOSITIONS AND METHODS

Applicant/Assignee:

Application No.: 11/691810   Filing Date: 27/Mar/2007

Abstract:An aqueous based antiperspirant/deodorant composition comprising (a) an antiperspirant active ingredient

(b) at least one water absorbing polymer pretreated with a non-aqueous polar solvent

and (c) water, wherein the pretreated water absorbing polymer inhibits the water absorbing properties of the polymer in the aqueous based composition prior to application to the skin.

Priority:

Inventor: JOSHI VIJAY K [US]; FRANCO PHILIP [US]


Application No.: US20080241089A1  Published: 02/Oct/2008

Title: LOW-RESIDUE DEODORANT OR ANTIPERSPIRANT STICK BASED ON AN OIL-IN-WATER DISPERSION/EMULSION

Applicant/Assignee:

Application No.: 11/938285   Filing Date: 11/Nov/2007

Abstract:Deodorant or antiperspirant sticks based on an oil-in-water dispersion/emulsion for application on the skin.

Priority: DE200510022523 Applic. Date: 2005-05-11; DE200510029776 Applic. Date: 2005-06-24; DE200610004957 Applic. Date: 2006-02-01; WO2006EP04371 Applic. Date: 2006-05-10; US20060788022P Applic. Date: 2006-03-30; US20060788028P Applic. Date: 2006-03-30

Inventor: BANOWSKI BERNHARD [DE]; WADLE ARMIN [DE]; CLAAS MARCUS [DE]


Application No.: US20080241101A1  Published: 02/Oct/2008

Title: Skin vitalizing composition for external use anti-aging preparation

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 12/155285   Filing Date: 02/Jun/2008

Abstract:The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.

Priority: JP20020177601 Applic. Date: 2002-06-18; JP20020323030 Applic. Date: 2002-11-06; US2004-931252 Applic. Date: 2004-09-01; US2002-314165 Applic. Date: 2002-12-09

Inventor: AMANO SATOSHI [JP]; OGURA YUKI [JP]; MATSUNAGA YUKIKO [JP]; TSUDA TAKANARI [JP]; AOYAMA YUKARI [JP]; KOGA NOBUYOSHI [JP]


Application No.: US20080241204A1  Published: 02/Oct/2008

Title: WETTING SOLUTION FOR WET WIPES FOR COSMETIC, PERSONAL HYGIENE, DERMATOLOGICAL AND/OR CLEANING PURPOSES

Applicant/Assignee: ZSCHIMMER & SCHWARZ GMBH & CO. KG

Application No.: 12/060018   Filing Date: 31/Mar/2008

Abstract:The present invention relates to a wetting solution for manufacturing wet wipes or other wet flexible materials, and to such wet wipes for cosmetic, body care, dermatological and/or cleaning purposes, such as cleaning wipes, facial cleaning wipes, make-up remover wipes, refreshment wipes, baby wipes, wet toilet paper or eyeglass cleaning wipes, wherein the preferably aqueous wetting solution contains at least one amino acid ester, preferably from the group of pyrrolidone carboxylic acid esters, as an emulsifier. The invention further relates to the use of such amino acid esters as emulsifiers in wetting solutions for manufacturing said wet tissues.

Priority: EP20070006765 Applic. Date: 2007-03-31

Inventor: LEIKAUF ULRICH [DE]


Application No.: US20080242573A1  Published: 02/Oct/2008

Title: MULTIPHASE PERSONAL CARE COMPOSITION COMPRISING A STRUCTURING SYSTEM THAT COMPRISES AN ASSOCIATIVE POLYMER, A LOW HLB EMULSIFIER AND AN ELECTROLYTE

Applicant/Assignee:

Application No.: 12/054853   Filing Date: 25/Mar/2008

Abstract:The present invention relates to a multiphase personal care composition. The multiphase personal care composition comprises an aqueous structured surfactant phase, a structuring system, and a benefit phase. The aqueous structured surfactant phase comprises from about 5% to about 16%, by weight of the multiphase personal care composition, of a lathering surfactant selected from the group consisting of anionic surfactants, nonionic surfactants, amphoteric surfactants, cationic surfactants or mixtures thereof and a structuring system. The structuring system comprises a non-ionic emulsifier having an HLB of from about 1.4 to about 13

about 0.05% to about 5%, by weight of the multiphase personal care composition, of an associative polymer

and an electrolyte. The benefit phase comprises from about 5% to about 30%, by weight of the multiphase personal care composition, of hydrophobic benefit material.

Priority: US20070921210P Applic. Date: 2007-03-30

Inventor: WEI KARL SHIQING [US]


Application No.: US20080242730A1  Published: 02/Oct/2008

Title: Hydroxamic Acid Derivatives and the Preparation Method Thereof

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 11/919131   Filing Date: 21/Mar/2006

Abstract:The present invention provides hydroxamic acid derivatives represented by the formula, having antioxidation, collagen biosynthesis promotion and skin pore contraction effects, and a method for preparation thereof. Further, the present invention provides skin-care external compositions for preventing skin aging, containing said hydroxamic acid derivatives represented by the formula as an active ingredient.

Priority: KR20050035986 Applic. Date: 2005-04-29; WO2006KR01019 Applic. Date: 2006-03-21

Inventor: RHO HO SIK [KR]; BAEK HEUNG SOO [KR]; LEE JEONG A [KR]; PARK CHANG MAN [KR]; KIM DUCK HOO [KR]; CHANG IH SOOP [KR]; LEE OK SUB [KR]


Application No.: US20080247960A1  Published: 09/Oct/2008

Title: Foaming Tropical Compositions

Applicant/Assignee: RECKITT BENCKISER INC

Application No.: 12/065333   Filing Date: 14/Sep/2006

Abstract:Improved aqueous foaming topical compositions for the application to the human body particularly to the skin which composition provides both a cleaning benefit, and a durable antimicrobial benefit.

Priority: US20050717794P Applic. Date: 2005-09-16; US20060787865P Applic. Date: 2006-03-31; WO2006GB03413 Applic. Date: 2006-09-14

Inventor: YUAN HAOMING [US]


Application No.: US20080247979A1  Published: 09/Oct/2008

Title: Use of a Hydrophobic Zeolite, that Contains and Gives a Slow Release of an Active Element, for Treatment of Skin

Applicant/Assignee:

Application No.: 12/065600   Filing Date: 13/Mar/2006

Abstract:The invention describes the use of a hydrophobic zeolite, that contains an active component, especially a disinfection element, as ethanol, iodine, phenol, cresol or hydrogen peroxide, in a composition for non-medical treatment of the skin, for example as a deodorant. The invention also describes the use of a hydrophobic zeolite, that contains an active component, especially a disinfection element, as ethanol, iodine, phenol, cresol or hydrogen peroxide, for manufacturing of a pharmaceutical preparation for treatment of skin related conditions and diseases, as skin infections. The hydrophobic zeolite is especially selected from that group that comprises silicalite, or hydrophobic ZMS-5, hydrophobic mordenite and hydrophobic zeolite Y.

Priority: SE20050000564 Applic. Date: 2005-03-14; WO2006SE00317 Applic. Date: 2006-03-13

Inventor: BENJAMINSON HAKAN [SE]; ANDERSON STAN [SE]


Application No.: US20080247985A1  Published: 09/Oct/2008

Title: Composition base containing solubilized allantoin and urea for topical preparations

Applicant/Assignee:

Application No.: 11/732962   Filing Date: 05/Apr/2007

Abstract:Substantially homogeneous topical preparations for cosmetic, veterinary, and pharmaceutical use comprise at least one active ingredient solubilized in a novel composition base. The composition base comprises solubilized allantoin at a level of at least 0.5% and urea at a level of at least 10% in an aqueous vehicle.

Priority:

Inventor: ZHANG JERRY [US]


Application No.: US20080247986A1  Published: 09/Oct/2008

Title: Hyaluronidase Inhibitor Containing Poly-Gamma-Glutamic Acid as an Effective Component

Applicant/Assignee: BIOLEADERS CORPORATION

Application No.: 12/090678   Filing Date: 21/Jun/2008

Abstract:The present invention relates to a hyaluronidase inhibitor containing poly-gamma-glutamic acid (PGA) as an active ingredient, a composition for maintaining skin elasticity and a composition for improving allergy, wherein each of the compositions contains PGA as an active ingredient. The inventive compositions containing PGA are effective in maintaining skin moisturization and skin elasticity by effectively inhibiting the activity of hyaluronidase which is an enzyme that degrades hyaluronic acid present in the skin dermis. Also, the compositions can relieve allergic symptoms by inhibiting the permeability of inflammatory cells.

Priority: KR20050099131 Applic. Date: 2005-10-20; WO2005KR03632 Applic. Date: 2005-10-31

Inventor: SUNG MOON HEE [KR]; PARK CHUNG [KR]; CHOI JAE CHUL [KR]; UYAMA HIROSHI [JP]; PARK SO LIM [KR]


Application No.: US20080247994A1  Published: 09/Oct/2008

Title: DNA vaccine

Applicant/Assignee: JUN NISHIHIRA

Application No.: 11/730745   Filing Date: 03/Apr/2007

Abstract:The present invention relates to a DNA vaccine consisting of a vector expressing a part or the whole of a polypeptide regulating production of an inflammatory cytokine, a pharmaceutical composition comprising the DNA vaccine, and a method of preventing or treating an inflammatory disease by using the pharmaceutical composition.

Priority:

Inventor: NISHIHIRA JUN [JP]; KOYAMA YOSHIKAZU [JP]; ONODERA SHIN [JP]


Application No.: US20080248071A1  Published: 09/Oct/2008

Title: Diffusing Particles Based on Organogelling Xerogel Fibers, Method for Preparing Same and Use in Cosmetic Formulations

Applicant/Assignee: PIERRE FABRE DERMO-COSMETIQUE UNIVERSITE PAUL SABATIER TOULOUSE III CENTRE NATIONAL DE LA RECHECHE SCIENTIFIQUE

Application No.: 11/992659   Filing Date: 29/Sep/2006

Abstract:The invention concerns particles consisting essentially of fibers of an organogelling substance in the form of xerogel (dry gel), the fibers being essentially oriented in a common direction and randomly aligned around the longest fiber. The organogelling substance is preferably 1,3:2,4-di-O-benzylidene-D-sorbitol. Said particles, which are in the form of spindles, have interesting optical properties

they have a total light transmittance higher than 0.80, with a diffuse transmittance higher than the specular transmittance. The invention also concerns a method for preparing said particles by solvent evaporation process, by solvent diffusion/evaporation process or by shearing process. The invention finally concerns active particles consisting of said particles whereon is immobilized a dermocosmetically active principle, a dermocosmetic composition comprising said particles or said active particles and a cosmetic treatment method which consists in applying on the skin said dermocosmetic composition.

Priority: FR20050010035 Applic. Date: 2005-09-30; WO2006EP66892 Applic. Date: 2006-09-29

Inventor: DOAT ANNE [FR]; PEREZ EMILE [FR]; RICO-LATTES ISABELLE [FR]; BORDAT PASCAL [FR]


Application No.: US20080249022A1  Published: 09/Oct/2008

Title: Antimicrobial Peptides Derived From Cap18

Applicant/Assignee: OCTOPLUS TECHNOLOGIES B.V ACADEMISCH ZIEKENHUIS LEIDEN

Application No.: 11/658415   Filing Date: 26/Jul/2005

Abstract:The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.

Priority: EP20040077175 Applic. Date: 2004-07-28; WO2005NL00545 Applic. Date: 2005-07-26

Inventor: GROTE JOHANNES JAKOBUS [NL]; DRIJFHOUT JAN WOUTER [NL]; HIEMSTRA PIETER SICCO [NL]; VONK MARCEL JAN [NL]; NELL MAARTJE JOHANNA [NL]; BLOEMBERG GUIDO VINCENT [NL]


Application No.: US20080249032A1  Published: 09/Oct/2008

Title: Derivatives of Arylsulfonamido-Substituted Hydroxamic Acid as Matrix Metalloproteinases Inhibitors

Applicant/Assignee: PROTERA S.R.L

Application No.: 11/659431   Filing Date: 29/Jul/2005

Abstract:Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.

Priority: WO2005EP53722 Applic. Date: 2005-07-29; IT2004FI00174 Applic. Date: 2004-08-03

Inventor: BERTINI IVANO [IT]; FRAGAI MARCO [IT]; LO CONTE MAURO [IT]; LUCHINAT CLAUDIO [IT]; NATIVI CRISTINA [IT]; VENTURI CHIARA [IT]


Application No.: US20080249042A1  Published: 09/Oct/2008

Title: All-Trans-Retinol: All-Trans-13,14-Dihydroretinol Saturase and Methods of Its Use

Applicant/Assignee: UNIVERSITY OF WASHINGTON

Application No.: 11/574976   Filing Date: 09/Sep/2005

Abstract:Compositions of all-trans-retinol: all-trans-13,14-dihydroretinal saturase and methods of use thereof are provided.

Priority: US20040609038P Applic. Date: 2004-09-09; WO2005US32462 Applic. Date: 2005-09-09

Inventor: MOISE ALEXANDER R [US]; KUKSA VLADIMIR A [US]; PALCZEWSKI KRZYSZTOF [US]


Application No.: US20080249064A1  Published: 09/Oct/2008

Title: Activities of an active principle obtained from powdered alfalfa seeds (Medicago sativa), active principle used and process of obtaining the same

Applicant/Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE DITE SILAB

Application No.: 11/902836   Filing Date: 26/Sep/2007

Abstract:The object of the invention is an active principle derived from a powder of alfalfa seeds (Medicago sativa) permitting counteracting, in a manner similar to retinol, the phenomenon of extrinsic aging of the skin, with anti-wrinkle and smoothing properties. The invention also covers the active principle, the procedure of obtaining the same, and the compositions including it.

Priority: FR20040000986 Applic. Date: 2004-02-02; US2005-047854 Applic. Date: 2005-02-02

Inventor: PAUFIQUE JEAN [FR]


Application No.: US20080253973A1  Published: 16/Oct/2008

Title: SENSATION MODIFYING TOPICAL COMPOSITION FOAM

Applicant/Assignee: FOAMIX LTD

Application No.: 11/971197   Filing Date: 08/Jan/2008

Abstract:This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier

(b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent

a warming agent

a relaxing or soothing agent

stimulating or refreshing agent

or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2005-532618 Applic. Date: 2005-12-22; US2004-911367 Applic. Date: 2004-08-04; US2004-835505 Applic. Date: 2004-04-28; US20070879213P Applic. Date: 2007-01-08; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; ZLATKIS ELLA [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]


Application No.: US20080253976A1  Published: 16/Oct/2008

Title: Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof

Applicant/Assignee:

Application No.: 12/062870   Filing Date: 04/Apr/2008

Abstract:Disclosed are personal care compositions, including compositions for oral, throat and skin care comprising a blend of naturally occurring flavor or perfume ingredients or essential oils containing such ingredients, wherein the blend provides excellent antimicrobial activity and comprises at least two components, a first acyclic component selected from citral, neral, geranial, geraniol and nerol and a second cyclic-containing component selected from eucalyptol, carvacrol and eugenol. Preferably, the blend comprises 3, 4, 5 or more of the above components. Greater synergy in terms of antimicrobial efficacy may be obtained the more different components are blended together. The present compositions are effective in killing, suppressing the growth of and/or altering metabolism of microorganisms including those which cause undesirable oral cavity conditions including plaque, caries, calculus, gingivitis, periodontal disease and malodor. Optionally the blend further comprises additional antimicrobial and/or anti-inflammatory components, preferably naturally-occurring as well.

Priority: US20070923652P Applic. Date: 2007-04-16

Inventor: SCOTT DOUGLAS CRAIG [US]; SANKER LOWELL ALAN [US]; GOULBOURNE ERIC ALTMAN [US]


Application No.: US20080253978A1  Published: 16/Oct/2008

Title: Derivatives of Pyrrolyltriazine Together with Methods for Obtaining Them and Their Use as Protecting Agents Uv Radiation

Applicant/Assignee: ISDIN, S.A

Application No.: 11/916450   Filing Date: 06/Jun/2006

Abstract:The present invention relates to new pyrrolyltriazine derivatives of general formula (I) together with method for obtaining them. The physico-chemical properties of said compounds allow them to be used as absorbents of UV radiation.

Priority: ES20050001334 Applic. Date: 2005-06-03; WO2006EP62937 Applic. Date: 2006-06-06

Inventor: TRULLAS CARLES [ES]; PELEJERO CARLES [ES]; PANYELLA DAVID [ES]; CORBERA JORDI [ES]; HOLENZ JORG [ES]; VANO DAVID [ES]


Application No.: US20080253981A1  Published: 16/Oct/2008

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 12/214501   Filing Date: 19/Jun/2008

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain sterically hindered amine salt compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US2005-201377 Applic. Date: 2005-08-10; US20040603590P Applic. Date: 2004-08-23

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MERVIN G [US]; MARTIN WANDA H [US]


Application No.: US20080253986A1  Published: 16/Oct/2008

Title: Cosmetic/dermatological compositions comprising naphthoic acid compounds and polyurethane polymers

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/076169   Filing Date: 14/Mar/2008

Abstract:Cosmetic/dermatological compositions for topical application and useful for the treatment, e.g., of acne, contain, formulated into a physiologically acceptable medium, at least one naphthoic acid compound and at least one polyurethane polymer or derivative thereof, the at least one naphthoic acid compound being dispersed therein.

Priority: FR20050009493 Applic. Date: 2005-09-16; WO2006IB03852 Applic. Date: 2006-09-15

Inventor: MALLARD CLAIRE [FR]; FERRARA EVE [FR]


Application No.: US20080254026A1  Published: 16/Oct/2008

Title: ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE

Applicant/Assignee: NOVARTIS VACCINES AND DIAGNOSTICS, INC

Application No.: 11/932472   Filing Date: 31/Oct/2007

Abstract:Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.

Priority: US2007-577390 Applic. Date: 2007-05-29; WO2004US37152 Applic. Date: 2004-11-04; US2007-578387 Applic. Date: 2007-03-27; WO2004US37281 Applic. Date: 2004-11-04; US2006-577642 Applic. Date: 2006-11-20; WO2004US36954 Applic. Date: 2004-11-04; US2007-578400 Applic. Date: 2007-01-03; WO2004US36955 Applic. Date: 2004-11-04; US2007-578401 Applic. Date: 2007-01-03; WO2004US37159 Applic. Date: 2004-11-04; WO2004US36958 Applic. Date: 2004-11-04; US2006-576943 Applic. Date: 2006-12-01; WO2004US36957 Applic. Date: 2004-11-04; US20030517337P Applic. Date: 2003-11-04; US20030525579P Applic. Date: 2003-11-26; US20040565710P Applic. Date: 2004-04-27; US20040565709P Applic. Date: 2004-04-26; US20040611794P Applic. Date: 2004-09-21; US20040565634P Applic. Date: 2004-04-27; US20040613885P Applic. Date: 2004-09-28

Inventor: LONG LI [US]; LUQMAN MOHAMMAD [US]; YABANNAVAR ASHA [US]; ZAROR ISABEL [US]; CHEN BAO-LU [US]; LU XIAOFENG [US]; LEE SANG HOON [US]; HURST DEBORAH [US]; AUKERMAN SHARON LEA [US]; LOPES DE MENEZES DANIEL E [US]


Application No.: US20080254033A1  Published: 16/Oct/2008

Title: Pharmaceutical Compositions Containing Antagonists to Lrp4, Lrp8 or Megalin for Treatment of Diseases

Applicant/Assignee:

Application No.: 10/586669   Filing Date: 21/Jan/2005

Abstract:The present invention provides LRP4, LRP8 and LRP2 (megalin) polypeptides

polynucleotides encoding such

modulators of LRP4, LRP8 and LRP2 activity

and pharmaceutical compositions for the treatment of diseases. Compositions of the invention contain a pharmaceutically acceptable carrier or excipient and at least one modulator that is capable of binding to or interfering with the activity of LRP4, LRP8, LRP2 and active fragments thereof. The invention provides modulators, such as antibodies, RNAi molecules, anti-sense molecules and ribozymes. Additionally, the invention includes methods for the treatment of diseases, such as proliferative diseases and degenerative diseases, and methods of administration of the compositions of the invention.

Priority: US20040538322P Applic. Date: 2004-01-21; WO2005US01883 Applic. Date: 2005-01-21

Inventor: PIERCE KRISTEN [US]; COLLINS AMY L TSUI [US]; ZHANG HONGBING [US]; WILLIAMS LEWIS THOMAS [US]; BEAURANG PIERRE ALVARO [US]


Application No.: US20080254035A1  Published: 16/Oct/2008

Title: Lipocalin Protein

Applicant/Assignee: ARES TRADING S.A

Application No.: 11/817296   Filing Date: 08/Mar/2006

Abstract:The invention is based on the discovery that the human protein referred to herein as INSP181 protein is a lipocalin.

Priority: GB20050004767 Applic. Date: 2005-03-08; WO2006GB00820 Applic. Date: 2006-03-08

Inventor: YORKE-SMITH MELANIE [CH]; POWER CHRISTINE [FR]; BOSCHERT URSULA [CH]


Application No.: US20080254055A1  Published: 16/Oct/2008

Title: Compositions for Regulation of Hair Growth

Applicant/Assignee:

Application No.: 12/056396   Filing Date: 27/Mar/2008

Abstract:Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing

and a dermatologically-acceptable carrier.

Priority: US20070922786P Applic. Date: 2007-04-11

Inventor: OBLONG JOHN ERICH [US]; STYCZYNSKI PETER B [US]; HENRY JAMES PATRICK [US]; SREEKRISHNA KOTIKANYADANAM [US]


Application No.: US20080254079A1  Published: 16/Oct/2008

Title: NOVEL COMPOSITIONS CONTAINING LYSOZYME AND C-1/C-4 POLYSACCHARIDES AND USE THEREOF IN ORAL CARE, COSMETOLOGY AND DERMATOLOGY, CONTRACEPTION, UROLOGY AND GYNECOLOGY

Applicant/Assignee: SAINT SIMEON LDA

Application No.: 12/100091   Filing Date: 09/Apr/2008

Abstract:A composition comprising a content of a lysozyme and a content of a C-1/C-4 polysaccharide is useful in oral care, cosmetology and dermatology, contraception, urology and gynecology. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. 37 CFR PRG 1.72(b).

Priority: US20070910880P Applic. Date: 2007-04-10

Inventor: FERRARI STEFANO [US]


Application No.: US20080254106A1  Published: 16/Oct/2008

Title: Use Of Pirlindole For The Treatment Of Diseases Which Are Characterized By Proliferation Of T-Lymphocytes And/Or Hyperproliferation Of Keratinocytes In Particular Atopic Dermatitis And Psoriasis

Applicant/Assignee: SWITCH BIOTECH AG

Application No.: 11/718476   Filing Date: 02/Nov/2005

Abstract:The present invention relates to the use of Pirlindole, if needed with suitable adjuvants and additives for the production of a medicament for the treatment of diseases characterized by hyperproliferation of keratinocytes and/or T cells, in particular psoriasis and neurodermatitis as well as compositions comprising Pirlindole and use thereof.

Priority: EP20040025961 Applic. Date: 2004-11-02; WO2005EP11697 Applic. Date: 2005-11-02

Inventor: BELL STEFAN [DE]


Application No.: US20080254107A1  Published: 16/Oct/2008

Title: METHOD AND DEVICE FOR TREATING BURSITIS

Applicant/Assignee: EXIST MARKETING PTY LTD

Application No.: 11/932933   Filing Date: 31/Oct/2007

Abstract:The present invention relates to a method for treating a subject for a condition or inflammation associated with oedema, excess body fluids or oedema and excess body fluids, or for treating a subject for an abscess, boil, blister or cyst. The method comprises applying to the skin surface covering a body part or region affected by said condition, inflammation, abscess, boil, blister or cyst a composition capable of transdermally attracting fluids from the body part or region or its proximity, wherein said composition comprises at least one adsorptive or absorptive agent, and leaving said composition in contact with the skin for sufficient time to allow said composition to transdermally absorb or adsorb at least a portion of the body fluids from said body part or region. The present invention also relates to compositions for absorbing or adsorbing fluids from a body part or region, and which are capable of transdermally attracting fluids from body parts or regions or their proximity.

Priority: AU20070901915 Applic. Date: 2007-04-10

Inventor: JACQUES DANNIEL [AU]


Application No.: US20080254150A1  Published: 16/Oct/2008

Title: Management of dermatitic symptoms of mammalian integument with emollient disinfectant formulations

Applicant/Assignee:

Application No.: 12/080070   Filing Date: 31/Mar/2008

Abstract:Botanically-sourced and botanically-derived emollient sanitation compositions for topical use are disclosed. Representative compositions generally aid reconstitution of the lipid profile of the stratum corneum by providing botanical lipids and/or lipid-derivatives that resemble human sebum-these components being ordinarily diminished with the use of conventional hand sanitizer products. Disclosed features and specifications may be variously controlled, adapted or optionally modified to realize, for example, improved hand sanitizer formulations. Representative embodiments of the present invention generally provide anti-microbial compositions blended with botanically sourced lipids and/or lipid-derivatives to control or otherwise improve dermatitic symptoms associated with frequent use of conventional hand sanitizer products.

Priority: US2003-611775 Applic. Date: 2003-06-30; US2000-478071 Applic. Date: 2000-01-03; US20070920604P Applic. Date: 2007-03-29

Inventor: RHEINS LAWRENCE A [US]; HILL JOHN C [US]; ASHLEY DAVID [US]; BROWN JAMES S [US]; REINHARDT JOHN [US]; BROWN JAMES H [US]


Application No.: US20080254157A1  Published: 16/Oct/2008

Title: Herbal composition for inflammatory disorders

Applicant/Assignee: PIRAMAL LIFE SCIENCES LIMITED

Application No.: 12/079853   Filing Date: 28/Mar/2008

Abstract:This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder.

The invention also relates to tumor necrosis factor- (TNF-alpha) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti-inflammatory agent.

Priority: IN2005MU01226 Applic. Date: 2005-09-30; WO2006IB53540 Applic. Date: 2006-09-28; US20050736443P Applic. Date: 2005-11-14

Inventor: CHAUHAN VIJAY [IN]; SUTHAR ASHISH [IN]; SAPRE DHANANJAY [IN]; BAL-TEMBE SWATI [IN]; GANGOPADHYAY ASHOK KUMAR [IN]; KULKARNI-ALMEIDA ASHA [IN]; PARIKH SAPNA HASIT [IN]; GUPTE RAVINDRA DATTATRAYA [IN]; DAGIA NILESH MADHUKAR [IN]; SHARMA SOMESH [IN]; DADARKAR SHRUTA SUDHEER [IN]; JADHAV MAHESH GUNDAJI [IN]; TANNU ADITI AMOL [IN]


Application No.: US20080255160A1  Published: 16/Oct/2008

Title: MAPK/ERK KINASE INHIBITORS

Applicant/Assignee:

Application No.: 11/958999   Filing Date: 18/Dec/2007

Abstract:Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds

methods and intermediates useful for making the compounds

and methods of using said compounds.

Priority: US20060870913P Applic. Date: 2006-12-20

Inventor: DONG QING [US]; GONG XIANCHANG [US]; KALDOR STEPHEN W [US]; KANOUNI TOUFIKE [US]; SCORAH NICHOLAS [US]; WALLACE MICHAEL B [US]; ZHOU FENG [US]


Application No.: US20080255223A1  Published: 16/Oct/2008

Title: Treatment and Prevention of Benign Pigmented Moles (Naevi) Using Artemisinine and the Derivatives Thereof

Applicant/Assignee:

Application No.: 12/089773   Filing Date: 19/Oct/2006

Abstract:A method of treating a benign pigmented mole or a dermatomycosis. The method comprises locally applying to a subject in need thereof artemisinine and/or one or more structurally related compounds. Also disclosed is a plaster which comprises a topical formulation comprising artemisinine and/or one or more structurally related compounds.

Priority: CH20050001686 Applic. Date: 2005-10-20; CH20060000514 Applic. Date: 2006-03-30; WO2006CH00583 Applic. Date: 2006-10-19

Inventor: SIFT CARTER ROSEMARIE [CH]


Application No.: US20080255253A1  Published: 16/Oct/2008

Title: ANIMAL MODEL FOR PROSTATIC STROMAL HYPERPLASIA

Applicant/Assignee: TAIHO PHARMACEUTICALS CO., LTD

Application No.: 12/138320   Filing Date: 12/Jun/2008

Abstract:The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia using the animal model. The animal model for prostatic stromal hyperplasia is produced by implanting the fetal urogenital sinus of a non-human animal under the skin or beneath the prostatic capsule of a non-human animal belonging to the species of the same as or different from the said animal. A substance effective for preventing/treating human benign prostatic hyperplasia can be screened by administering a test substance to the animal model and measuring the preventive or therapeutic effect of the test substance upon the implanted tissue (fetal urogenital sinus or tissue derived therefrom).

Priority: JP20010138123 Applic. Date: 2001-05-09; US2003-477077 Applic. Date: 2003-11-07; WO2002JP04477 Applic. Date: 2002-05-08

Inventor: ODA NOBUYUKI [JP]; MIYOSHI KAZUHISA [JP]; HARUNO AKIHIRO [JP]; MIYAKE HIDEKAZU [JP]


Application No.: US20080260655A1  Published: 23/Oct/2008

Title: SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES

Applicant/Assignee:

Application No.: 12/025547   Filing Date: 04/Feb/2008

Abstract:The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.

Priority: US20060858747P Applic. Date: 2006-11-14; US20070915859P Applic. Date: 2007-05-03; US20070899176P Applic. Date: 2007-02-02; US2007-940290 Applic. Date: 2007-11-14

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; ZIV ENBAL [IL]; EINI MEIR [IL]; BERMAN TAL [IL]; DANZIGER JORGE [IL]; KEYNAN RITA [IL]; SCHUZ DAVID [IL]


Application No.: US20080260662A1  Published: 23/Oct/2008

Title: Sunscreen Compositions Comprising Carotenoids

Applicant/Assignee:

Application No.: 11/795668   Filing Date: 23/Jan/2006

Abstract:The invention concerns methods of treating or preventing the effects of irradiation in a human or non-human animal using carotenoid compounds, preferably diadinoxanthin, diatoxanthin and/or fucoxanthin as well as photoprotective compositions and their use to prepare photoprotective or photoprotected products.

Priority: GB20050001365 Applic. Date: 2005-01-21; WO2006GB00220 Applic. Date: 2006-01-23

Inventor: JOHNSEN GEIR [NO]; LYSAA PER AGE [NO]; AAMODT KRISTIN [NO]


Application No.: US20080260674A1  Published: 23/Oct/2008

Title: Cosmetic Use of Amphoteric Polysaccharide Compounds Containing Cationic Polymer Chain (S)

Applicant/Assignee:

Application No.: 11/660381   Filing Date: 18/Aug/2005

Abstract:The invention relates to the cosmetic use, especially for the cosmetic treatment of keratin materials, of amphoteric polysaccharide compounds containing cationic polymer chain(s), which may be obtained by grafting and polymerization of ethylenic monomers of formula (I), Q<-> onto an anionic polysaccharide of formula (II): in the presence of a catalytic system based on potassium permanganate (KMnO4) and sulfuric acid (H2SO4). The invention also relates to compositions comprising at least one cosmetic active agent and at least one of these amphoteric polysaccharide compounds, in a cosmetically acceptable medium.

Priority: FR20040008997 Applic. Date: 2004-08-19; US20040612170P Applic. Date: 2004-09-23; WO2005EP09985 Applic. Date: 2005-08-18

Inventor: PHILIPPE MICHEL [FR]


Application No.: US20080260675A1  Published: 23/Oct/2008

Title: Depolymerized Scleroglucan for Regulating and Improving the Moisture Content of the Skin

Applicant/Assignee: EVONIK GOLDSCHMIDT GMBH

Application No.: 12/146692   Filing Date: 26/Jun/2008

Abstract:The use of depolymerized scleroglucan alone, or in combination with one or more active ingredients as a moisturizer, and as anti-inflammatory active ingredient for protecting and for restoring a healthy skin barrier in the field of cosmetic or dermatological skincare is disclosed.

Priority: DE200510026061 Applic. Date: 2005-06-07; US2006-448953 Applic. Date: 2006-06-07

Inventor: FARWICK MIKE [DE]; MACZKIEWITZ URSULA [DE]; MECKING MARIA [DE]; SCHICK GEORG [US]; WOLLENWEBER UTE [DE]


Application No.: US20080260677A1  Published: 23/Oct/2008

Title: Transdermal Topical Composition and Its Uses

Applicant/Assignee:

Application No.: 11/909050   Filing Date: 22/Mar/2006

Abstract:An emollient component is provided in a composition, suitable for topical application to skin, comprising a fugitive solvent base comprising at least one alcohol. One advantage of the invention is that the irritancy potential of the composition due to the alcoholic fugitive solvent base is reduced.

Priority: GB20050006141 Applic. Date: 2005-03-24; WO2006GB01058 Applic. Date: 2006-03-22

Inventor: PANDYA ANANT K [GB]


Application No.: US20080260685A1  Published: 23/Oct/2008

Title: PRODRUGS OF CC-1065 ANALOGS

Applicant/Assignee: IMMUNOGEN INC

Application No.: 12/144612   Filing Date: 23/Jun/2008

Abstract:Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described

such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytotoxic drugs in a targeted fashion.

Priority: US2007-649822 Applic. Date: 2007-01-05; US2005-217351 Applic. Date: 2005-09-02; US2003-692856 Applic. Date: 2003-10-27; US2002-116053 Applic. Date: 2002-04-05

Inventor: ZHAO ROBERT YONGXIN [US]; CHARI RAVI V J [US]


Application No.: US20080260749A1  Published: 23/Oct/2008

Title: Novel Tetrahydropyridothiophenes

Applicant/Assignee: NYCOMED GMBH 4SC AG

Application No.: 11/920501   Filing Date: 24/May/2006

Abstract:Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Priority: EP20050104495 Applic. Date: 2005-05-25; EP20050112155 Applic. Date: 2005-12-14; WO2006EP62617 Applic. Date: 2006-05-24

Inventor: PEKARI KLAUS [DE]; SCHMIDT MATHIAS [DE]; BAR THOMAS [DE]; BECKERS THOMAS [DE]; GIMMNICH PETRA [DE]


Application No.: US20080260786A1  Published: 23/Oct/2008

Title: Process for making encapsulated particles

Applicant/Assignee:

Application No.: 12/112732   Filing Date: 30/Apr/2008

Abstract:Method for preparing an active-containing starch matrix and the free flowing, dry powder that results from such a process. The active ingredients can be released (deposited) onto a surface by normal triggering mechanisms, which include the action of a liquid or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels and protection of the active while still being able to delivery this to a substrate when triggered. Additionally, ingredients incompatible and reactive with each other can be blended together as sold/used as a one piece system and no reactions will occur until the matrix is broken or triggered.

Priority: WO2003US25404 Applic. Date: 2003-08-13; US2006-276191 Applic. Date: 2006-02-17; US2003-639845 Applic. Date: 2003-08-13; US2002-219548 Applic. Date: 2002-08-15

Inventor: SOLAREK DANIEL B [US]


Application No.: US20080260788A1  Published: 23/Oct/2008

Title: Skin Cleaning Composition

Applicant/Assignee: GREENBRIDGE ENVIRONMENTAL CONTROL LIMITED

Application No.: 11/569287   Filing Date: 17/May/2005

Abstract:The present invention describes a skin cleaning and disinfecting composition comprising an active component, wherein the active component comprises at least one alcohol, at least one halogen. The present invention also describes corresponding anti-bacterial, anti-viral and anti-fungal compositions, as well as a method of manufacturing same.

Priority: GB20040010968 Applic. Date: 2004-05-17; WO2005GB01909 Applic. Date: 2005-05-17

Inventor: MALYSZEWIEZ CHRISTOPHER [GB]; PEARS IAN GEOFFREY [GB]; LEVENE RAE CLYDE [GB]


Application No.: US20080260808A1  Published: 23/Oct/2008

Title: DEVICE FOR SMOOTHING WRINKLES ON HUMAN SKIN

Applicant/Assignee: BIOFARMITALIA S.P.A

Application No.: 12/098624   Filing Date: 07/Apr/2008

Abstract:Device for smoothing wrinkles on human skin and for enabling skin sections between successive wrinkles to achieve prolonged contact with cosmetic and/or pharmaceutical substances carried by said device.

Priority: IT2007MI00798 Applic. Date: 2007-04-18

Inventor: PINNA FAUSTO [IT]; PINNA MARCO [IT]


Application No.: US20080260864A1  Published: 23/Oct/2008

Title: Topical Compositions for the Treatment of Depilation-Induced Irritation or Prevention Thereof

Applicant/Assignee: MEDIDERMIS LTD

Application No.: 12/067219   Filing Date: 18/Oct/2006

Abstract:The present invention relates to topical compositions comprising as active ingredients Aluminium Chloride and Sulfur for treatment of skin irritation induced by depilation. Said compositions have pharmaceutical and/or cosmetic and/or quasi cosmetic properties. The present invention also involves methods of making and methods of using such compositions. Furthermore, the present invention consists of a method for prevention and/or treatment of skin irritation induced by depilation.

Priority: US20050728562P Applic. Date: 2005-10-21; WO2006IL01198 Applic. Date: 2006-10-18

Inventor: DASCALU AVI [IL]


Application No.: US20080260875A1  Published: 23/Oct/2008

Title: NOVEL SKIN CARE COMPOSITIONS AND METHODS

Applicant/Assignee: BIOPHYSICA, INC

Application No.: 12/134762   Filing Date: 06/Jun/2008

Abstract:Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.

Priority: US2006-509485 Applic. Date: 2006-08-24; US20050713882P Applic. Date: 2005-09-01

Inventor: SOVAK MILOS [US]; SELIGSON ALLEN L [US]; PROKOP JIRI [CZ]


Application No.: US20080261258A1  Published: 23/Oct/2008

Title: Immune Cell Biosensors and Methods of Using Same

Applicant/Assignee: AMAOX, INC

Application No.: 11/631574   Filing Date: 11/Jul/2005

Abstract:The present invention relates to immunological cells that are useful in detecting changes in physiological states, which provide for methods of diagnosing diseases or monitoring the course of patient therapy. Also provided are arrays of antigen presenting cell-specific markers for detecting changes in physiological states, and methods of detecting such changes.

Priority: US20040586546P Applic. Date: 2004-07-09; US20040612454P Applic. Date: 2004-09-23; US20040613733P Applic. Date: 2004-09-28; US20040614924P Applic. Date: 2004-09-29; WO2005US24491 Applic. Date: 2005-07-11

Inventor: SMITH MILTON G [US]; CRAWFORD KEITH D [US]


Application No.: US20080261291A1  Published: 23/Oct/2008

Title: Method of Obtaining Cyanogenic Glycoside and Related Glycosides, as Well as Genin and Sapogenins Derivatives of Plants of the Family Sapotaceae for the Preparation of Cosmetics and Dermatological Compositions

Applicant/Assignee:

Application No.: 11/632961   Filing Date: 21/Jul/2004

Abstract:Procedure for the obtaining of genin and sapogenins extracts by enzymatic hydrolysis of kernels derived of the family Sapotaceae, genus Calocarpum, Chrysophyllum and Lucuma. The enzymes that catalyzes the hydrolysis are exogenous beta-glucosidases, of vegetable or microbial origin. The process uses mainly diverse kernel (seeds removed of the endocarp) derived but can also use the cyanogenic glycoside, lucumin and the related similar glycosides directly. It is also object of protection the process for the obtaining of these glycosides, starting of those kernels derived and the usage of these in the obtaining of genin and sapogenins and its uses in cosmetic and dermatologic compositions. The genin and sapogenins extracts are the main products used with these basic similar aims. The obtained genin extract are used in topical compositions to promote the opening of the pore facilitating the epithelial penetration or it can be used as flavouring or scent agent in foods or in alternating similar uses like in perfumery. The obtained sapogenins extract are used in topical compositions as astringent, defoliant, to favour oily skin penetration, to promote the renovation of the skin, to combat the epithelial aging, the growth of the hair or slow its fallen. The effect of oily skin penetration is enhanced synergised with a lipidic phase of the same Sapotaceae family. Besides the sapogenins have bacteriostatic and fungistatic activity in the compositions, in its topical use or in diverse preparations.

Priority: WO2004MX00052 Applic. Date: 2004-07-21

Inventor: DE LA LLATA ROMERO LUIS [MX]


Application No.: US20080261304A1  Published: 23/Oct/2008

Title: METHODS AND COMPOSITIONS FOR ENHANCING DELIVERY OF DOUBLE-STRANDED RNA OR A DOUBLE-STRANDED HYBRID NUCLEIC ACID TO REGULATE GENE EXPRESSION IN MAMMALIAN CELLS

Applicant/Assignee: NASTECH PHARMACEUTICAL COMPANY INC

Application No.: 12/013274   Filing Date: 11/Jan/2008

Abstract:A double-stranded RNA, preferably a small, interfering (si)RNA or a siHybrid, to which cholesterol moieties are linked.

Priority: US2005-107371 Applic. Date: 2005-04-15; US20040564543P Applic. Date: 2004-04-20

Inventor: AHMADIAN MOHAMMAD [US]; CUI KUNYUAN [US]; CHEN LISHAN [US]; CHEN SHU-CHIH [US]; HOUSTON MICHAEL E [US]


Application No.: US20080261865A1  Published: 23/Oct/2008

Title: Oxidized Lipids and Uses Thereof in the Treatment of Inflammatory Diseases and Disorders

Applicant/Assignee:

Application No.: 10/567543   Filing Date: 27/May/2004

Abstract:Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

Priority: US2003-445347 Applic. Date: 2003-05-27; WO2004IL00453 Applic. Date: 2004-05-27

Inventor: HARATS DROR [IL]; GEORGE JACOB [IL]; HALPERIN GIDEON [IL]


Application No.: US20080261899A1  Published: 23/Oct/2008

Title: AGENT FOR CONTROLLING Bcl-2 EXPRESSION COMPRISING GINSENOSIDE F1 AS AN ACTIVE COMPONENT

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 12/135663   Filing Date: 09/Jun/2008

Abstract:The present invention relates to an agent for controlling Bcl-2 expression comprising ginsenoside F1 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) represented by the following formula 1 as an active component.

Priority: KR20020085716 Applic. Date: 2002-12-28; US2003-539012 Applic. Date: 2003-12-27; WO2003KR02859 Applic. Date: 2003-12-27

Inventor: CHO SI-YOUNG [KR]; LEE EUN-HEE [KR]; KIM SU-JUNG [KR]; SHIN EUI-SEOK [KR]; CHANG HUI-KYOUNG [KR]; KIM DUCK-HEE [KR]; YEOM MYOENG HOON [KR]; WOE KWANG-SIK [KR]; LEE TAE-RYONG [KR]; SIM YOUNG-CHUL [KR]


Application No.: US20080261925A1  Published: 23/Oct/2008

Title: COMPOUNDS, COMPOSITIONS, KITS AND METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID

Applicant/Assignee:

Application No.: 11/966504   Filing Date: 28/Dec/2007

Abstract:Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(S)-1alpha-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1alpha,25-dihydroxyvitamin D3, 2-methylene-1alpha,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-19-nor-(24R)-1alpha,25-dihydroxyvitamin D2, 2-methylene-(20R,25S)-19,26-dinor-1alpha,25-dihydroxyvitamin D3, 2-methylene-19-nor-1alpha-hydroxy-pregnacalciferol, 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20S)-1alpha-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1alpha-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1alpha-hydroxy-19-nor-bishomopregnancalciferol, (2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1alpha-hydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1alpha,25-dihydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof. Compounds that activate retinoic acid receptors, such as retinoyls and retinoyl esters, include 13-cis-retinoic acid, all-trans-retinoic acid, (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexeneyl)nona-2,4,6,8-tetraenoic acid, 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthoic acid, 4-[1-(3,5,5,8,8-pentamethyl-tetralin-2-yl)ethenyl]benzoic acid, retinobenzoic acid, ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate, retinoyl t-butyrate, retinoyl pinacol, retinoyl cholesterol, an isomer thereof, a prodrug thereof for oral compositions, an ester thereof, a salt thereof, and/or, a solute thereof. Combinations of such active ingredients demonstrate synergistic efficacy.

Priority: US20060882705P Applic. Date: 2006-12-29; US20070017217P Applic. Date: 2007-12-28; US20070017219P Applic. Date: 2007-12-28

Inventor: CLAGETT-DAME MARGARET [US]; DELUCA HECTOR F [US]; NIEVES NIRCA J [US]; PLUM LORI A [US]; KAISER MARY E [US]


Application No.: US20080261978A1  Published: 23/Oct/2008

Title: Chemokine receptor modulators

Applicant/Assignee:

Application No.: 12/073648   Filing Date: 07/Mar/2008

Abstract:The invention provides compounds of Formula (I) and pharmaceutical compositions comprising compounds of Formula (I). These compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers

Priority: US20070905580P Applic. Date: 2007-03-08

Inventor: CLARK MICHAEL P [US]; LOCKWOOD MARK A [US]; WAGNER FLORENCE F [US]; NATCHUS MICHAEL G [US]


Application No.: US20080262414A1  Published: 23/Oct/2008

Title: SINGLE USE APPLICATOR CARTRIDGE FOR AN ELECTROKINETIC DELIVERY SYSTEM AND METHOD FOR SELF ADMINISTRATION OF MEDICAMENTS

Applicant/Assignee: TRANSPORT PHARMACEUTICALS, INC

Application No.: 12/105764   Filing Date: 18/Apr/2008

Abstract:An applicator cartridge for use with a device for electrokinetically delivering a medicament to a treatment site, the cartridge including: an applicator head including an active electrode, and a conductive path extending between a pair of electrical contacts, wherein the electrical contacts electrically engage respective contacts on the device when the cartridge is inserted into the device

a matrix support surface of said applicator head adjacent the active electrode

a matrix attached to the matrix support surface and in contact with the active electrode, the matrix having an exposed surface adapted to be applied to the treatment site

a medicament or a medicament and an electrically conductive carrier carried by said matrix

a removable lid covering the exposed surface of the matrix and sealed to the applicator head, the lid is conductively coupled to the applicator head and completes the conductive path on the applicator head, wherein removal of the lid breaks the conductive path.

Priority: US20070913151P Applic. Date: 2007-04-20

Inventor: BARSNESS MICHAEL S [US]; ETHEREDGE ROBERT W [US]


Application No.: US20080262444A1  Published: 23/Oct/2008

Title: Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment

Applicant/Assignee: BIOSERENTACH CO., LTD

Application No.: 11/883118   Filing Date: 30/Jan/2006

Abstract:Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.

Priority: JP20050023276 Applic. Date: 2005-01-31; JP20050296691 Applic. Date: 2005-10-11; WO2006JP301480 Applic. Date: 2006-01-30

Inventor: TAKADA KANJI [JP]


Application No.: US20080262445A1  Published: 23/Oct/2008

Title: Transdermal Delivery of Hydrophobic Bioactive Agents

Applicant/Assignee: DERMATRENDS, INC

Application No.: 11/574928   Filing Date: 08/Sep/2005

Abstract:A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT3) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

Priority: US20040607922P Applic. Date: 2004-09-08; WO2005US31825 Applic. Date: 2005-09-08

Inventor: HSU TSUNG-MIN [US]; HICKEY ALAN T J [US]; JACOBSON ERIC C [US]; GRICENKO NICOLE T [US]


Application No.: US20080262581A1  Published: 23/Oct/2008

Title: CURRENT DENSITY DETECTION AND CONTROL SYSTEM AND METHOD FOR AN ELECTROKINETIC DELIVERY OF MEDICAMENTS

Applicant/Assignee: TRANSPORT PHARMACEUTICALS, INC

Application No.: 12/104515   Filing Date: 17/Apr/2008

Abstract:An apparatus to monitor current density in the application of medicament to a treatment site of a mammalian user of a electrokinetic device including: an applicator cartridge including an active electrode, a matrix carrying a medicament or a medicament and an electrically conductive carrier

a device including an electrical power source connectable to the active electrode, a counter electrode, and an electronic circuit configured to control the application of electrical current through the active electrode to establish a conductive path extending from the power source, through the active electrode, matrix, the treatment site, the user and the counter electrode electrically connected to the power source, and an array of contacts monitoring current density flowing through the matrix and to the treatment site, wherein the array of sensors are arranged monitor the current density at various locations of the matrix and a contact area between the matrix and skin above the treatment site.

Priority: US20070912261P Applic. Date: 2007-04-17

Inventor: BARSNESS MICHAEL S [US]; DOHERTY EDWARD J [US]


Application No.: US20080267889A1  Published: 30/Oct/2008

Title: Cosmetic Cooling Composition

Applicant/Assignee:

Application No.: 11/664509   Filing Date: 13/Sep/2005

Abstract:The invention relates to a cosmetic composition having a cooling effect, particularly a clear gel or a spray. The composition has a long-lasting cooling effect of about 8 hours and comprises a cooling complex consisting of 0.05-0.15% Menthyl Lactate, 0.1-0.2% Menthyl PCA and 0.05-0.2% Ethyl Menthane Carboxamide.

Priority: DE200410048987 Applic. Date: 2004-10-04; WO2005EP09992 Applic. Date: 2005-09-13

Inventor: CERNASOV DOMNICA [US]; MOGHE BHAL [US]; PATEL AMIT [US]; SCHAMPER THOMAS [US]; HWANG DONNA HUI-ING [US]; ESPOSITO ANTHONY [US]


Application No.: US20080267892A1  Published: 30/Oct/2008

Title: 5,6-Diphenyl-1,2,4-Triazinic Dimeric Derivatives and the Use Thereof in the Form of Sun-Protective Agents

Applicant/Assignee: PIERRE FABRE DERMO-COSMETIQUE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) UNIVERSITE CLAUDE BERNARD LYON 1

Application No.: 11/579538   Filing Date: 04/May/2005

Abstract:The invention relates to 5,6-diphenyl-1,2,4-triazinic compounds of general formula (I), wherein identical or different R1, R2, R3 and R4 represent a hydrogen, fluoride, chloride or bromine atom, C1 to C12 linear or branched alkyl, C1 A C18 linear or branched hydroxy, alkoxy poly(ethoxy)-alkoxy with a C1 to C4 alkyl fragment and an ethoxy number ranging from 1 to 4, amino or mono or di-alkylamino with a C1 to C4 alkyl fragment group, X is ortho-, meta- or paraphenylene, 4,4'-biphenylene, 2,4- or 2,6- or 3,4- or 3,5-pyridinylene, 2,2'-bipyridinylene, meta- or paraphenylenediamino, ethylenediamine, 2,2'-piperazinylene, diacyl of formula -(R4CO)2-, wherein r represents a phenyl radical, a 3 to 10 carbon, phenanthrene or anthracene atoms alkyl chain except 1,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)benzene of 2,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)pyridine and of 2,6-bis(5,6-diphenyl-1,2,

4-triazin-3-yl)pyridine, to cosmetic compositions containing said compounds and to the use thereof in the form of sun filters or light-protective agents.

Priority: FR20040004811 Applic. Date: 2004-05-05; WO2005FR01132 Applic. Date: 2005-05-04

Inventor: PICOUL WILLY [FR]; CIUFOLINI MARCO [CA]; BORDAT PASCAL [FR]; TARROUX ROGER [FR]


Application No.: US20080268035A1  Published: 30/Oct/2008

Title: Cationic Polymer Nanoparticles Encapsulating An Active Ingredients, And The Cosmetic Composition Containing The Same

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 12/090680   Filing Date: 18/Oct/2006

Abstract:Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.

Priority: KR20050098057 Applic. Date: 2005-10-18; KR20060101316 Applic. Date: 2006-10-18; WO2006KR04238 Applic. Date: 2006-10-18

Inventor: KIM YONG JIN [KR]; KIM JIN WOONG [KR]; RYU JU HEE [KR]; SHIM JONG WON [KR]; KIM JUN OH [KR]; CHANG IH SEOP [KR]


Application No.: US20080268547A1  Published: 30/Oct/2008

Title: Systems and Methods for Indicating Oxidation of Consumer Products

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 11/547763   Filing Date: 24/Mar/2005

Abstract:The present invention relates to systems and methods using colorimetric indicators of oxidation in consumer products. In particular, betalains are used as oxidation indicators in food, pharmaceutical, and other products.

Priority: US20040561043P Applic. Date: 2004-04-09; WO2005US09695 Applic. Date: 2005-03-24

Inventor: AVENT JASON [US]; NAIK NEEL [US]; MABRY TOM J [US]; PASSINEAU MICHAEL J [US]


Application No.: US20080269095A1  Published: 30/Oct/2008

Title: SOLUBLE PATCH

Applicant/Assignee: L'OREAL

Application No.: 12/169779   Filing Date: 09/Jul/2008

Abstract:An article, preferably a patch, containing: a support in the form of at least one sheet containing fibres that are water-soluble at a temperature of 0-30 DEG C., and a composition carried by the support, containing at least one water-soluble gelling agent which swells in less than 30 seconds in water at a temperature of 20 DEG C. to 30 DEG C.

Priority: FR20050053752 Applic. Date: 2005-12-07; US2006-567336 Applic. Date: 2006-12-06; US20050752051P Applic. Date: 2005-12-21

Inventor: AUBRUN-SONNEVILLE ODILE [FR]


Application No.: US20080269120A1  Published: 30/Oct/2008

Title: ADP-ribosyl transferase fusion variant proteins

Applicant/Assignee: BIOAXONE THERAPEUTIQUE INC

Application No.: 11/808773   Filing Date: 12/Jun/2007

Abstract:The present invention relates to novel chimeric C3-like Rho antagonists and their use for promoting repair and neuron survival in injured mammalian central and peripheral nervous system and for treating or preventing cancer.

Priority: CA20012342970 Applic. Date: 2001-04-12; CA20012362004 Applic. Date: 2001-11-13; CA20022367636 Applic. Date: 2002-01-15; US2006-643940 Applic. Date: 2006-12-22; US2004-902878 Applic. Date: 2004-08-02; US2004-902959 Applic. Date: 2004-08-02; US20030506162P Applic. Date: 2003-09-29

Inventor: MCKERRACHER LISA [CA]; MUNZER JON SCOTT [CA]


Application No.: US20080269282A1  Published: 30/Oct/2008

Title: Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof

Applicant/Assignee: GENMEDICA THERAPEUTICS SL

Application No.: 11/573089   Filing Date: 09/May/2008

Abstract:This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO

also known as vascular adhesion protein-1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.

Priority: US20040598010P Applic. Date: 2004-08-02; WO2005EP53778 Applic. Date: 2005-08-02

Inventor: CLAUZEL LUC MARTI [ES]; VICENTE SILVIA GARCIA [ES]; YRAOLA FONT FRANCESC [ES]; ROYO EXPOSITO MIRIAM [ES]; PALOMERA FERNANDO ALBERICIO [ES]; OLARTE ANTONIO ZORZANO [ES]


Application No.: US20080269685A1  Published: 30/Oct/2008

Title: Solvent-cast microneedle arrays containing active

Applicant/Assignee:

Application No.: 12/148180   Filing Date: 16/Apr/2008

Abstract:In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Priority: US20070923861P Applic. Date: 2007-04-16; US20070925262P Applic. Date: 2007-04-18

Inventor: SINGH PARMINDER [US]; WORSHAM ROBERT WADE [US]; TRAUTMAN JOSEPH C [US]; BAYRAMOV DANIR [US]; BOWERS DANNY LEE [US]; KLEMM ANDY [US]; KLEMM STEVEN RICHARD [US]; CHEN GUOHUA [US]


Application No.: US20080269754A1  Published: 30/Oct/2008

Title: Preparation Tools and Methods of Using the Same

Applicant/Assignee: ORTHOBOND, INC

Application No.: 12/042979   Filing Date: 05/Mar/2008

Abstract:Various devices and methods for accessing and preparing treatment sites within the intervertebral disc space for subsequent negligible-incision surgical (NIS) or percutaneous procedures to treat disc degeneration and disc related back pain are disclosed. Also disclosed is a method for performing a percutaneous spine procedure including preparing a treatment site within the intervertebral disc space for subsequent delivery of a biomaterial to treat disc degeneration and disc related back pain.

Priority: US20070893355P Applic. Date: 2007-03-06; US20070910228P Applic. Date: 2007-04-05; US20070977639P Applic. Date: 2007-10-04; US20080021609P Applic. Date: 2008-01-16

Inventor: LUTZ GREGORY E [US]; HULL HANS [US]; LIN JIMMY [US]


Application No.: US20080274146A1  Published: 06/Nov/2008

Title: Application System for a Plaster Containing an Active Ingredient and a Controlled-Release Agent for Said Active Ingredient

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 12/066216   Filing Date: 25/Aug/2006

Abstract:The present invention relates to an application system for an active ingredient release system, comprising a film-form application strip, which is in each case bonded detachably to an active ingredient-containing plaster and a separate active ingredient release regulator separate there from.

Priority: DE200520014347U Applic. Date: 2005-09-09; WO2006EP08366 Applic. Date: 2006-08-25

Inventor: BARTHOLOMAUS JOHANNES [DE]; KUGELMANN HEINRICH [DE]


Application No.: US20080274155A1  Published: 06/Nov/2008

Title: Chimeric Cannulae Proteins, Nucleic Acids Encoding Them And Methods For Making And Using Them

Applicant/Assignee: VERENIUM CORPORATION

Application No.: 10/593846   Filing Date: 24/Mar/2005

Abstract:The invention provides chimeric cannulae polypeptides and nanotubules and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. In one aspect, the chimeric proteins and polymers (e.g., nanotubules, tubules, bundles, balls, fibers, filaments, sheets, threads, textiles) of the invention comprise a detectable moiety, e.g., a fluorescent protein. In one aspect, the invention provides a flame retardant or heat resistant device comprising a sheeting, a covering, a coating or an adhesive comprising a chimeric protein of the invention.

Priority: US20040556393P Applic. Date: 2004-03-24; US20040605192P Applic. Date: 2004-08-27; WO2005US09927 Applic. Date: 2005-03-24

Inventor: BARTON NELSON R [US]; O'DONOGHUE EILEEN [US]; SHORT RYAN [US]; FREY GERHARD [US]; WEINER DAVID [US]; ROBERTSON DAN E [US]; BRIGGS STEVEN [US]; ZORNER PAUL [US]


Application No.: US20080274999A1  Published: 06/Nov/2008

Title: Hyaluronic Acid Fraction with Moisturizing and Anti-Wrinkle Properties

Applicant/Assignee: NOVOZYMES BIOPOLYMER A/S

Application No.: 11/722814   Filing Date: 22/Dec/2005

Abstract:A moisturizing, cosmetic, or anti-wrinkle product comprising hyaluronic acid or a salt thereof, wherein the hyaluronic acid or salt thereof has an average molecular weight in the range of 0.7-0.9 MDa, compositions comprising said product, and uses of said product.

Priority: DK20050000006 Applic. Date: 2005-01-03; US20050641857P Applic. Date: 2005-01-06; WO2005DK00822 Applic. Date: 2005-12-22

Inventor: ABDELLAOUI KHADIJA SCHWACH [DK]; HALBYE SOREN [DK]


Application No.: US20080275113A1  Published: 06/Nov/2008

Title: Antimicrobial Compositions, Products, And Methods Of Use

Applicant/Assignee:

Application No.: 12/113960   Filing Date: 02/May/2008

Abstract:The present invention comprises an antimicrobial composition. More particularly to an antimicrobial composition that comprises a. from about 0.01% to about 15% of at least one non-anionic surfactant, by weight of the composition

b. from about 0.01% to about 15% of at least one acid, by weight of the composition

c. from about 0% to about 99.85% of water, by weight of the composition

and wherein the composition is foaming.

Priority: US20070927742P Applic. Date: 2007-05-04

Inventor: HUETTER THOMAS EDWARD [US]; INGLIN THOMAS ALFRED [US]; COFFINDAFFER TIMOTHY WOODROW [US]; MARTIN KELLY LEE [US]; LEUKART BRIAN GILBERT [US]; KUHLMAN DENNIS EUGENE [US]


Application No.: US20080275118A1  Published: 06/Nov/2008

Title: HEALTH AND COSMETIC COMPOSITION AND REGIME FOR STIMULATING HAIR GROWTH AND THICKENING ON THE HEAD, INCLUDING THE SCALP, EYELASHES, AND EYEBROWS, AND WHICH DISCOURAGES HAIR LOSS

Applicant/Assignee:

Application No.: 12/137799   Filing Date: 12/Jun/2008

Abstract:This invention relates to compositions and processes for stimulating the growth of mammalian hair comprising the topical application of compositions comprising a hair growth stimulating and/or hair loss prevention agent, and a hair and/or skin lightening and/or neutralization agent, in association with a topical pharmaceutical carrier. Unlike other products, the composition of the invention can be used with dyed/treated hair so as to not affect the color of the hair.

Priority:

Inventor: SHAW MARI M [US]; COHEN MARC S [US]; SWARTZ NANCY G [US]


Application No.: US20080279764A1  Published: 13/Nov/2008

Title: METHOD AND COMPOSITION FOR TREATING CANCER

Applicant/Assignee:

Application No.: 12/044761   Filing Date: 07/Mar/2008

Abstract:A method for treating cancer, preventing cancer or delaying the progression of a cancer in an animal or a human comprising the step of: administering to the animal or the human having a cancer a composition in an amount effective to treat cancer, prevent cancer or delay the progression of cancer in the animal or the human. The composition comprises a pharmaceutically acceptable excipient, and ascorbate which is joined to a carrier structure containing an anti-cancer active agent, said carrier structure being capable of releasing the anti-cancer agent in the presence of a reactive oxygen species.

Priority: US20070905902P Applic. Date: 2007-03-09

Inventor: MANGANARO ANTHONY [US]; ROCKWELL KAREN [US]


Application No.: US20080279793A1  Published: 13/Nov/2008

Title: Flavonoids as Synergists for Enhancing the Action of Self-Tanning Substances

Applicant/Assignee:

Application No.: 11/996846   Filing Date: 10/May/2006

Abstract:The invention relates to the use of at least one flavonoid having an uncharged flavan skeleton as synergist for enhancing the action of self-tanning substances, such as trioses and tetroses, in cosmetic and dermatological formulations and to corresponding novel compositions and to the preparation thereof.

Priority: DE200510035683 Applic. Date: 2005-07-27; US20050702983P Applic. Date: 2005-07-28; US20060784588P Applic. Date: 2006-03-23; WO2006EP04384 Applic. Date: 2006-05-10

Inventor: RUDOLPH THOMAS [DE]; BUCHHOLZ HERWIG [DE]; MEDUSKI JERZY [FR]


Application No.: US20080279794A1  Published: 13/Nov/2008

Title: Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin

Applicant/Assignee:

Application No.: 12/214998   Filing Date: 24/Jun/2008

Abstract:The use of (a) hydroxydiphenyl ether compounds of formula wherein R1, R2 and R3 are each independently of the others hydrogen

hydroxy

C1-C20alkyl

hydroxy-substituted C1-C20alkyl

C5-C7cycloalkyl

C1-C20alkoxy

C1-C6alkylcarbonyl

phenyl

or phenyl-C1-C3alkyl

R4 is hydrogen, C1-C20alkyl

hydroxy-substituted C1-C20alkyl

C5-C7cycloalkyl

hydroxy

formyl

acetonyl

allyl

carboxy

carboxy-C1-C3alkyl

carboxyallyl

C2-C20alkenyl

C1-C6alkylcarbonyl

C1-C3alkylcarbonyl-C1-C3alkyl

phenyl

or phenyl-C1-C3alkyl

and R5 is hydrogen

C1-C20alkoxy

or C1-C6alkylcarbonyl

as melanogenesis inhibitors and for lightening the skin.

Priority: EP20030405542 Applic. Date: 2003-07-16; US2004-564712 Applic. Date: 2004-07-07; WO2004EP51379 Applic. Date: 2004-07-07

Inventor: BASCHONG WERNER [CH]; SCHNYDER MARCEL [CH]


Application No.: US20080279797A1  Published: 13/Nov/2008

Title: Cosmetic nanocomposites based on in-situ cross-linked POSS materials

Applicant/Assignee:

Application No.: 11/801287   Filing Date: 09/May/2007

Abstract:A cosmetic composition for caring for and/or making up the skin, lips and/or body in the form of a film, which is non-transferable, long-lasting with a comfortable feeling of use to consumers over long periods of wear time. The composition contains graftable POSS which forms a film when it cures in situ. The invention also relates to using such film for preparing a cosmetic composition and a makeup process and makeup kit comprising the product.

Priority:

Inventor: MAITRA PRITHWIRAJ [US]; ZHENG TAO [US]


Application No.: US20080279900A1  Published: 13/Nov/2008

Title: GEL USEFUL FOR THE DELIVERY OF COSMETIC ACTIVE INGREDIENTS

Applicant/Assignee: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A

Application No.: 11/938001   Filing Date: 09/Nov/2007

Abstract:A gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles is described.

Priority: WO2007EP54574 Applic. Date: 2007-05-11

Inventor: LONGO ANTONIO [IT]; SANTANIELLO MOSE [IT]; RISI PAOLA [IT]


Application No.: US20080279901A1  Published: 13/Nov/2008

Title: Composition comprising encapsulated silicone compounds

Applicant/Assignee: L'OREAL

Application No.: 12/003026   Filing Date: 19/Dec/2007

Abstract:The present invention relates to a cosmetic composition intended for the care and/or make-up of keratinous substance(s) comprising, in a physiologically acceptable medium, at least one compound X, one compound Y and at least one catalyst, with at least one of the compounds X or Y being a polyorganosiloxane, and said compounds X and Y being capable of reacting together by a hydrosilylation reaction in the presence of a catalyst, with at least one compound from the compounds X and Y being present in said composition in an encapsulated form, said catalyst being combined with at least one of said encapsulated compound X or Y.

Priority: FR20060055681 Applic. Date: 2006-12-20; US20070883175P Applic. Date: 2007-01-03

Inventor: PRIGENT FANNY [FR]; SIMMONET JEAN-THIERRY [FR]


Application No.: US20080280835A1  Published: 13/Nov/2008

Title: Novel Use of Peptide Compounds For Treating Muscle Pain

Applicant/Assignee:

Application No.: 12/063956   Filing Date: 18/Aug/2006

Abstract:The present invention is directed to the use of a class of peptide compounds for treating non-inflammatory musculoskeletal pain or/and non-inflammatory osteoarthritic pain.

Priority: EP20050017977 Applic. Date: 2005-08-18; US20060811840P Applic. Date: 2006-06-08; US20060811859P Applic. Date: 2006-06-08; WO2006EP08171 Applic. Date: 2006-08-18

Inventor: BEYREUTHER BETTINA [DE]; STOHR THOMAS [DE]


Application No.: US20080280838A1  Published: 13/Nov/2008

Title: Composition Containing Ginsenoside F1 and Egcg for Preventing Skin Damage

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 10/599290   Filing Date: 01/Jun/2004

Abstract:The present invention relates to a skin-care composition containing ginsenoside F1 and EGCG. More particularly, the present invention relates to an inhibitor of UV-induced apoptosis in epidermal cells showing an excellent skin-care effect by the synergistic interaction of the said ginsenoside F1 and EGCG even at low concentrations, and to a method for inhibiting apoptosis in epidermal cells.

Priority: KR20040020800 Applic. Date: 2004-03-26; WO2004KR01303 Applic. Date: 2004-06-01

Inventor: CHO SI YOUNG [KR]; KANG BYUNG YOUNG [KR]; YEOM MYEONG HOON [KR]; LEE TAE RYONG [KR]; CHANG IH SEOP [KR]


Application No.: US20080280958A1  Published: 13/Nov/2008

Title: Topically applicable pharmaceutical preparation

Applicant/Assignee: NYCOMED GMBH

Application No.: 12/149250   Filing Date: 29/Apr/2008

Abstract:A topical pharmaceutical preparation for administering a slightly soluble PDE4 inhibitor is described. A surprisingly good systemic bioavailability is observed with this dosage form.

Priority: DE20021023828 Applic. Date: 2002-05-28; EP20020011830 Applic. Date: 2002-05-28; DE20031011613 Applic. Date: 2003-03-14; US2005-515698 Applic. Date: 2005-08-11; WO2003EP05524 Applic. Date: 2003-05-27

Inventor: BOLLE CHRISTINA [DE]; LINDER RUDOLF [DE]


Application No.: US20080280989A1  Published: 13/Nov/2008

Title: Hydroxybenzamide Derivatives, the Method For Preparing Thereof and the Cosmetic Composition Containing the Same

Applicant/Assignee:

Application No.: 11/990223   Filing Date: 20/Mar/2006

Abstract:Disclosed is a hydroxybenzamide derivative represented by the following Formula. A method for preparing the same and a cosmetic composition comprising the same are also disclosed. More particularly, the hydroxybenzamide derivative is obtained by reacting a hydroxybenzoic acid having a protecting group introduced thereto with a hydroxyphenyl amine to form a benzamide derivative and by hydrolyzing the benzamide derivative in an aqueous base solution to form a hydroxybenzamide derivative. The cosmetic composition comprising the hydroxybenzamide derivative as an active ingredient has excellent anti-oxidative, anti-aging and skin wrinkle-alleviating effects. wherein R1 represents a C1 (approx.) C10 alkyl group, and n is an integer ranging from 1 to 3.

Priority: KR20050076184 Applic. Date: 2005-08-19; WO2006KR01006 Applic. Date: 2006-03-20

Inventor: KIM SUNG JOONG [KR]; BAEK HEUNG SOO [KR]; RHO HO SIK [KR]; KIM DUCK HEE [KR]; CHANG IH SEOP [KR]; LEE OK SUB [KR]; SHIN HONG JU [KR]; PARK WOO RAM [KR]


Application No.: US20080281355A1  Published: 13/Nov/2008

Title: Joining Element

Applicant/Assignee: ETECH AG

Application No.: 11/913656   Filing Date: 04/May/2006

Abstract:Disclosed is a joining element ( 10 ), especially a suture material for surgical use. Said joining element ( 10 ) is composed of a first material ( 12 ) that is essentially rigid during impingement by a relatively short-lasting tensile load on opposite sides as well as a second material ( 11 ) which is connected to the first material. The second material is substantially rigid during impingement by said tensile load on opposite sides while contracting slowly during a second period of time that is longer than the first period of time.

Priority: CH20050000834 Applic. Date: 2005-05-04; WO2006EP62061 Applic. Date: 2006-05-04

Inventor: MAYER JORG [CH]; GANZ JOCHEN [CH]; KELLER BEAT [CH]; HERTEL RALPH [CH]


Application No.: US20080286211A1  Published: 20/Nov/2008

Title: Using mucin glycoproteins in combination with therapeutic agents to treat epithelial lesions and disorders of impaired mucin function

Applicant/Assignee:

Application No.: 12/150082   Filing Date: 24/Apr/2008

Abstract:The present invention features methods of treating a patient having an epithelial lesion or disorder of impaired mucin function. The present invention further features methods of treating pain associated with epithelial lesions and disorders of impaired mucin function. Epithelial lesions and disorders of impaired mucin function can be treated using a pharmaceutical composition containing mucin glycoproteins in combination with therapeutic agents, e.g., trefoil polypeptides.

Priority: US20070914692P Applic. Date: 2007-04-27

Inventor: BARKER NICHOLAS P [US]


Application No.: US20080286217A1  Published: 20/Nov/2008

Title: Sunscreen compositions and methods

Applicant/Assignee:

Application No.: 11/803188   Filing Date: 14/May/2007

Abstract:Sunscreen compositions are provided for protecting skin from sun-induced damage comprising (i) at least one UV-B or UV-A/UV-B sunblock active, (ii) at least one meroterpene and (iii) a dermatological acceptable carrier. Preferably, the sunblock active will be a UV-A/UV-B sunblock active or said sunscreen compositions will further comprise at least one UV-A sunblock active. Suitable meroterpenes include plant extracts having one or more meroterpene-enriched fractions, especially suited are Bakuchiol and derivatives of Bakuchiol. These skin protective compositions may optionally include an effective amount of one or more skin protective ingredients such as antioxidants, vitamins, anti-inflammatory agents, self-tanning agents and mixtures thereof.

Priority:

Inventor: CHAUDHURI RATAN K [US]


Application No.: US20080286221A1  Published: 20/Nov/2008

Title: Anionic Ethyl Methacrylate Copolymers and Use Thereof

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 11/665881   Filing Date: 19/Oct/2005

Abstract:The present invention relates to copolymers which comprise ethyl methacrylate, at least one alpha,beta-ethylenically unsaturated amide group-containing compound and at least one monoethylenically unsaturated carboxylic acid in copolymerized form, to cosmetic and pharmaceutical compositions which comprise at least one such copolymer, and to the use of these copolymers.

Priority: DE200410051648 Applic. Date: 2004-10-22; WO2005EP11239 Applic. Date: 2005-10-19

Inventor: KIM SON NGUYEN [DE]; WINTER GABI [DE]; LAUBENDER MATTHIAS [DE]


Application No.: US20080286223A1  Published: 20/Nov/2008

Title: Compositions Having a High Antiviral and Antibacterial Efficacy

Applicant/Assignee: THE DAIL CORPORATION

Application No.: 11/791257   Filing Date: 05/Dec/2005

Abstract:Antimicrobial compositions having a rapid antiviral and antibacterial effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain (a) a disinfecting alcohol, (b) an organic acid, and (c) water, wherein the composition has a pH of about 5 or less.

Priority: US20040634464P Applic. Date: 2004-12-09; WO2005US43910 Applic. Date: 2005-12-05

Inventor: FULS JANICE LYNN [US]; TAYLOR TIMOTHY J [US]; FOX PRISCILLA S [US]; RODGERS NANCY D [US]; TOWNER HARRY ERNEST [US]; DALTON JAMES [US]


Application No.: US20080286296A1  Published: 20/Nov/2008

Title: Cyclic-Dinucleotides and Its Conjugates as Adjuvants and Their Uses in Pharmaceutical Compositions

Applicant/Assignee:

Application No.: 12/092747   Filing Date: 08/Nov/2006

Abstract:The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP20050024266 Applic. Date: 2005-11-08; WO2006EP10693 Applic. Date: 2006-11-08

Inventor: EBENSEN THOMAS [DE]; MORR MICHAEL [DE]; GUZMAN CARLOS A [DE]


Application No.: US20080286299A1  Published: 20/Nov/2008

Title: FILM-FORMING RESINS AS A CARRIER FOR TOPICAL APPLICATION OF PHARMACOLOGICALLY ACTIVE AGENTS

Applicant/Assignee: JALEVA, LLC

Application No.: 12/182372   Filing Date: 30/Jul/2008

Abstract:The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

Priority: US20030517319P Applic. Date: 2003-11-03; US20050734608P Applic. Date: 2005-11-07; US2004-754430 Applic. Date: 2004-01-09; WO2006US43572 Applic. Date: 2006-11-07; US2008-091043 Applic. Date: 2008-07-28

Inventor: BATTAGLIA ALEX [US]


Application No.: US20080286349A1  Published: 20/Nov/2008

Title: SYSTEMS, DEVICES, AND METHODS FOR PASSIVE TRANSDERMAL DELIVERY OF ACTIVE AGENTS TO A BIOLOGICAL INTERFACE

Applicant/Assignee:

Application No.: 12/122630   Filing Date: 16/May/2008

Abstract:Systems, devices, and methods for transdermal delivery of one or more therapeutic active agents to a biological interface. A transdermal drug delivery system is provided for passive transdermal delivery of one or more ionizable active agents to a biological interface of a subject. A transdermal drug delivery system includes a backing substrate, and an active agent layer. The active layer includes a thickening agent, a plasticizer, and a therapeutically effective amount of an ionizable active agent.

Priority: US20070957126P Applic. Date: 2007-08-21; US20070956895P Applic. Date: 2007-08-20; US20070955850P Applic. Date: 2007-08-14; US20070938961P Applic. Date: 2007-05-18

Inventor: NOMOTO YOUHEI [JP]; KANAMURA KIYOSHI [JP]; ISHIKAWA IZUMI [JP]; ISHIDA MAYUKO [JP]; ISHIKAWA CHIZUKO [JP]; SAITO AKIYOSHI [JP]


Application No.: US20080286367A1  Published: 20/Nov/2008

Title: Compositions containing benefit agent composites pre-emulsified using colloidal cationic particles

Applicant/Assignee: AMCOL INTERNATIONAL CORPORATION

Application No.: 12/152364   Filing Date: 14/May/2008

Abstract:A cleansing or a surface-conditioning composition comprising a mixture of (i) and (ii) in water: i) a surfactant selected from the group consisting of anionic, non-ionic, zwitterionic, cationic, and mixtures thereof

and ii) a hydrophobic benefit agent in a particulate form having a mean particle size in the range of 1-1,000 micron, and a specific gravity of >=1, not encapsulated within a film or a capsule-like enclosure, the particulate hydrophobic benefit agent comprising: a) a physically-modified form of the hydrophobic benefit agent

and b) a deposition-aid material bonded to the surface of the physically-modified benefit agent material, wherein the bonding between the two said materials is achieved prior to addition to i), wherein said deposition-aid material is not a surfactant having a weight average molecular weight of less than 5,000 Dalton.

Priority: US20070917832P Applic. Date: 2007-05-14

Inventor: SENGUPTA ASHOKE K [US]; LIN ILONA [US]; ST ONGE JASON [US]; HUGHES MELANIE J [GB]


Application No.: US20080286387A1  Published: 20/Nov/2008

Title: Standardized method for recovering enriched Indian date extract (IDE), properties of IDE and applications thereof

Applicant/Assignee:

Application No.: 11/751033   Filing Date: 20/May/2007

Abstract:Disclosed are (i) a standardized method for the recovery of the polyphenolic contents from the seed coats of Tamarindus indica L. (ii) a standardized polyphenolic extract (10%-90%) from the seed coat of Tamarindus indica L. (standardized Indian date extract) and uses thereof as oral/topical, "skin care" and "hair care" nutra-cosmetic formulations. The standardized Indian Date extract of the present invention exhibits anti-collagenase, anti-elastase, anti-5-alpha-reductase and anti-hyaluronidase activities. The standardized Indian date extract of the present invention is suitable for oral/topical, "skin care" and "hair care" nutra-cosmetic formulations either singly or as "cosmetic blends" with other carefully chosen natural plant actives.

Priority:

Inventor: MAJEED MUHAMMED [US]; BAMMI RAJINDER KUMAR [IN]; SANKARAN NATARAJAN [IN]; PRAKASH SUBBAFAKSHMI [US]; ANAND SUSMITHA [IN]; KANHANGAD GANGADHARAN GEETHA [IN]


Application No.: US20080287392A1  Published: 20/Nov/2008

Title: Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate

Applicant/Assignee: SOLARTIUM LLC

Application No.: 12/091462   Filing Date: 16/Oct/2006

Abstract:This invention relates to wound-healing pharmaceutical or cosmetic (anti-skin aging) compositions in the form of a cream based on amino acids and sodium hyaluronate.

Priority: IT2005MI02035 Applic. Date: 2005-10-26; WO2006EP09966 Applic. Date: 2006-10-16

Inventor: CONTI FRANCO [IT]


Application No.: US20080287442A1  Published: 20/Nov/2008

Title: Organic Compounds

Applicant/Assignee: NABRIVA THERAPEUTICS FORSCHUNGS GMBH

Application No.: 11/814673   Filing Date: 11/Jan/2007

Abstract:14-O-[(((C1-6)Alkoxy-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[(((C1-6)Mono- or dialkylamino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-8)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl-(C0-5)-alkyl)-phenylsulfanyl)-acetyl]-mutilins 14-O-[((Guanidino-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Thioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Isothioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.

Priority: EP20060000827 Applic. Date: 2006-01-16; WO2007AT00009 Applic. Date: 2007-01-11

Inventor: THIRRING KLAUS [AT]; ASCHER GERD [AT]; PAUKNER SUSANNE [AT]; HEILMAYER WERNER [AT]; NOVAK RODGER [AT]


Application No.: US20080287495A1  Published: 20/Nov/2008

Title: Novel benzo[d][1,3]-dioxol derivatives

Applicant/Assignee:

Application No.: 11/498334   Filing Date: 31/Jul/2006

Abstract:The present invention relates to an isotopologue of Compound 1 substituted with deuterium at the methylene carbon of the benzodioxol ring. The isotopologues of this invention selective serotonin reuptake inhibitors (SSRIs) and possess unique biopharmaceutical and metabolic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these deuterated isotopologues and methods of treating diseases and conditions that are responsive to increased neuronal serotonin transmission, alone and in combination with additional agents.

Priority: US20050704073P Applic. Date: 2005-07-29

Inventor: TUNG ROGER [US]


Application No.: US20080287502A1  Published: 20/Nov/2008

Title: Transdermal Administration of Proton Pump Inhibitors

Applicant/Assignee: DERMATRENDS, INC

Application No.: 11/547335   Filing Date: 30/Jul/2008

Abstract:A method and composition for the transdermal administration of proton pump inhibitors such as substituted pyridyl methylsulfinyl benzimidazoles, and in particular, omeprazole, lansoprazole, esomeprazole, pantoprazole and raberprazole. The method and composition include the use of a hydroxide-releasing agent as a permeation enhancer to increase the flux of the protein pump inhibitor through a patient's skin or mucosal tissues and optionally also include the use of a carrier such as 1,3-butanediol, dipropylene glycol, and hexylene glycol.

Priority: US20040557790P Applic. Date: 2004-03-30; WO2005US10813 Applic. Date: 2005-03-30

Inventor: HSU TSUNG-MIN [US]; JACOBSON ERIC C [US]; HICKEY ALAN T J [US]; GRICENKO NICOLE T [US]; LUO ERIC C [US]


Application No.: US20080287552A1  Published: 20/Nov/2008

Title: Process for Obtaining an Active Ingredient for Enhancing Cutaneous Mechanical Strength, Active Ingredient and Compositions

Applicant/Assignee: SOCIETE INDUSTRIESLLE LIMOUSINE D'APPLICATION (SILAB) LIEUDIT MADRIAS

Application No.: 12/093716   Filing Date: 17/Nov/2006

Abstract:The object of the invention is a process for obtaining an active ingredient for increasing the mechanical strength of the skin, wherein the process utilizes the following steps: Solubilization of rye fibers and/or seeds and/or bran in water, Simultaneous or successive enzymatic hydrolysis or hydrolyses, Separation of soluble and insoluble phases by filtration, centrifuging, decanting, Treatment of the active fraction, and Sterilizing filtration. The product obtained by the process, cosmetic compositions containing the product, and method of using the product are also disclosed.

Priority: FR20050053497 Applic. Date: 2005-11-18; WO2006FR51188 Applic. Date: 2006-11-17

Inventor: PAUFIQUE JEAN [FR]


Application No.: US20080287857A1  Published: 20/Nov/2008

Title: Device and method for single-needle in vivo electroporation

Applicant/Assignee:

Application No.: 11/894653   Filing Date: 20/Aug/2007

Abstract:Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue

Priority: US2007-804703 Applic. Date: 2007-05-18; US2007-704591 Applic. Date: 2007-02-09; US20060772255P Applic. Date: 2006-02-11

Inventor: KJEKEN RUNE [US]; MATHIESEN IACOB [NO]; TJELLE TORUNN ELISABETH [NO]; MCHUGH GEORGE [US]


Application No.: US20080292193A1  Published: 27/Nov/2008

Title: Image Processing Method and Apparatus

Applicant/Assignee: FOTONATION VISION LIMITED

Application No.: 11/752925   Filing Date: 24/May/2007

Abstract:An image processing technique includes acquiring a main image of a scene and determining one or more facial regions in the main image. The facial regions are analysed to determine if any of the facial regions includes a defect. A sequence of relatively low resolution images nominally of the same scene is also acquired. One or more sets of low resolution facial regions in the sequence of low resolution images are determined and analysed for defects. Defect free facial regions of a set are combined to provide a high quality defect free facial region. At least a portion of any defective facial regions of the main image are corrected with image information from a corresponding high quality defect free facial region.

Priority:

Inventor: BIGIOI PETRONEL [IE]; CORCORAN PETER [IE]; STEINBERG ERAN [US]


Application No.: US20080292560A1  Published: 27/Nov/2008

Title: SILICONE IN GLYCOL PHARMACEUTICAL AND COSMETIC COMPOSITIONS WITH ACCOMMODATING AGENT

Applicant/Assignee:

Application No.: 12/049203   Filing Date: 14/Mar/2008

Abstract:A carrier, composition or foam formulation comprising

a silicone

about 25% to about 98% of a solvent selected from the group consisting of (1) a propylene glycol or derivative and (2) a polyethylene glycol (PEG) or derivative or mixtures thereof

0% to about 48% of at least one secondary solvent

and an Accommodating Agent or Complex

and methods of treatment. A hygroscopic silicone in glycol containing composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and a therapeutic agent.

Priority: US2008-014088 Applic. Date: 2008-01-14; US20070918025P Applic. Date: 2007-03-14; US20070880434P Applic. Date: 2007-01-12; US20070919303P Applic. Date: 2007-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; ZLATKIS ELLA [IL]; BERMAN TAL [IL]; SCHUZ DAVID [IL]


Application No.: US20080292561A1  Published: 27/Nov/2008

Title: Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents

Applicant/Assignee: GLAXO GROUP LIMITED

Application No.: 12/092974   Filing Date: 07/Nov/2006

Abstract:A compound of formula (I): is claimed wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl

R1 represents phenyl, pyridyl or thienyl wherein the phenyl group may be optionally substituted by one or two groups independently selected from fluorine, cyano, -C(O)OCH3 and -C(O)OCH2CH3, and the pyridyl group may be optionally substituted by one fluorine group

and R2 represents methyl or ethyl

along with physiologically functional derivatives thereof, pharmaceutical compositions and formulations thereof, combinations thereof, methods of treatment employing such compounds and processes for preparing the compounds.

Priority: GB20050022880 Applic. Date: 2005-11-09; WO2006EP10730 Applic. Date: 2006-11-07

Inventor: BIGGADIKE KEITH [GB]; HOUSE DAVID [GB]; INGLIS GRAHAM GEORGE ADAM [GB]; MACDONALD SIMON JOHN FAWCETT [GB]; MCLAY IAIN MCFARLANE [GB]; SKONE PHILIP ALAN [GB]


Application No.: US20080292568A1  Published: 27/Nov/2008

Title: 3-Deoxyglucosone and skin

Applicant/Assignee: DYNAMIS THERAPEUTICS, INC

Application No.: 11/818997   Filing Date: 15/Jun/2007

Abstract:The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

Priority: US2002-198706 Applic. Date: 2002-07-18; US20020392530P Applic. Date: 2002-06-27; US20020373103P Applic. Date: 2002-04-17

Inventor: TOBIA ANNETTE [US]; KAPPLER FRANCIS [US]


Application No.: US20080292608A1  Published: 27/Nov/2008

Title: Compounds and Compositions as Ppar Modulators

Applicant/Assignee: IRM LLC

Application No.: 12/092254   Filing Date: 07/Nov/2006

Abstract:The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US20050734592P Applic. Date: 2005-11-07; WO2006US43587 Applic. Date: 2006-11-07

Inventor: EPPLE ROBERT [US]; XIE YONGPING [US]; WANG XING [US]; RUSSO ROSS [US]; COW CHRISTOPHER [US]; AZIMIOARA MIHAI [US]


Application No.: US20080292618A1  Published: 27/Nov/2008

Title: INTRANUCLEAR PROTEIN TRANSDUCTION THROUGH A NUCLEOSIDE SALVAGE PATHWAY

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA U.S. GOVERNMENT, DEPARTMENT OF VETERANS AFFAIRS

Application No.: 12/126810   Filing Date: 23/May/2008

Abstract:Provided herein are conjugate molecules containing a substrate for a nucleoside transport pathway linked to an active agent, wherein the conjugate can be transported into a cell or into the nucleus of a cell via a cellular nucleoside transport pathway. Further provided are methods of delivering a conjugate molecule to a target cell expressing a nucleoside transport pathway, wherein the conjugate contains a substrate for the nucleoside transport pathway linked to an active agent. Also provided are methods for screening for conjugates that are transported by nucleoside transport pathways. Further provided are methods of treating a patient having a disease or disorder affecting tissues expressing nucleoside transport pathways, in which a conjugate containing an agent effective in treating the disorder is administered to the patient. Also provided are methods of treating a patient having an autoimmune disorder involving administering to the patient a compound that inhibits a nucleoside transport pathway.

Priority: US20070931855P Applic. Date: 2007-05-24

Inventor: WEISBART RICHARD H [US]


Application No.: US20080292668A1  Published: 27/Nov/2008

Title: Water-Free Cosmetic Preparation

Applicant/Assignee:

Application No.: 11/628558   Filing Date: 10/Jul/2006

Abstract:A water-free composition, in particular a cosmetic composition, in the form of a pencil with a cast or extruded lead or a workable paste which is suitable for cosmetic uses, in particular in the field of decorative cosmetics, for coloring, improving the appearance of and caring for keratinic materials such as for example the skin, semi-mucous membranes and mucous membranes, eyelashes, eyebrows and the hair. That preparation includes a specifically matched combination of water-soluble and lipid-soluble active substances in the form of a so-called "active substance cocktail". The production and use of that composition are also described.

Priority: DE200520010761U Applic. Date: 2005-07-08; DE200510057593 Applic. Date: 2005-12-02; WO2006EP06735 Applic. Date: 2006-07-10

Inventor: BAARS BEATRICE [DE]; BUGLA MANFRED [DE]; LOTZERICH-BERNHARD KERSTIN [DE]


Application No.: US20080292682A1  Published: 27/Nov/2008

Title: METHOD FOR TREATING ALLERGIC DERMATITIS

Applicant/Assignee: BOVAL COMPANY, L.P

Application No.: 11/754052   Filing Date: 25/May/2007

Abstract:A method for treating oleoresin induced allergic dermatitis by topically contacting an affected area with a therapeutically effective amount of one or more biopolymers for a sufficient amount of time to enable the one or more biopolymers to have an effect and removing the one or more biopolymers from the affected area. The oleoresin can be urushiol, isosolenopsin A, or a combination thereof. The one or more biopolymer can be albumin. The one or more biopolymers can provide a localized anti-inflammatory effect.

Priority:

Inventor: YARBOROUGH CODY L [US]


Application No.: US20080292686A1  Published: 27/Nov/2008

Title: Vaccine

Applicant/Assignee:

Application No.: 10/491482   Filing Date: 30/Sep/2002

Abstract:The present invention provides novel intradermal vaccines and novel uses for adjuvants in the preparation of intradermal vaccines, and also novel methods of treatment comprising them. The intradermal adjuvants, and methods, of the present invention comprise a saponin and a sterol, wherein the saponin and sterol are formulated in a liposome. The intradermal adjuvants are used in the manufacture of intradermal vaccines for humans, and in the intradermal treatment of humans.

Priority: GB20010023580 Applic. Date: 2001-10-01; WO2002EP10931 Applic. Date: 2002-09-30

Inventor: GARCON NATHALIE [BE]


Application No.: US20080292703A1  Published: 27/Nov/2008

Title: Antitumoral Bioconjugates of Hyaluronic Acid or Its Derivatives Obtained by Indirect Chemical Conjugation, and Their Use in the Pharmaceutical Field

Applicant/Assignee:

Application No.: 11/989716   Filing Date: 02/Aug/2006

Abstract:The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.

Priority: IT2005PD00242 Applic. Date: 2005-08-03; WO2006EP07717 Applic. Date: 2006-08-02

Inventor: RENIER DAVIDE [IT]; BETTELLA FABIO [IT]


Application No.: US20080292711A1  Published: 27/Nov/2008

Title: Polysiloxane Coated Metal Oxide Particles

Applicant/Assignee:

Application No.: 11/886732   Filing Date: 20/Mar/2006

Abstract:The invention provides novel coated metal oxide particles, wherein metal oxide particles are coated with a sunscreen on a polysiloxane basis with UV-A and/or UV-B and/or UV-C and/or broadband filter activity and a process for producing coated metal oxide particles and their use especially in cosmetic or dermatological formulations for the protection against harmful effects of sunlight.

Priority: EP20050006450 Applic. Date: 2005-03-23; WO2006EP02537 Applic. Date: 2006-03-20

Inventor: BERG-SCHULTZ KATJA [CH]; VOLLHARDT JUERGEN H [CH]; WESTENFELDER HORST [DE]; SIT FINTAN [SG]


Application No.: US20080292734A1  Published: 27/Nov/2008

Title: COMPOSITIONS AND METHODS FOR TREATMENT OF DERMAL SCARRING AND WRINKLING

Applicant/Assignee:

Application No.: 12/178597   Filing Date: 23/Jul/2008

Abstract:Compositions and methods for treatment of dermal scarring and wrinkling, by application to the skin of a cosmetically effective amount of Plantago major or Plantago Lanceolata. The plantain may be utilized in powdered form in an aqueous paste or poultice, or in a crème base or ointment that is applied to the skin for various periods of time from 1 to 10 hours at a frequency of 1-12 times per week, for a period of 3-50 weeks or more. The composition is effective to remediate dermal scarring and wrinkling, and at least partially restore skin to an undamaged, undeteriorated state.

Priority: WO2007US61006 Applic. Date: 2007-01-24; US20060761627P Applic. Date: 2006-01-24

Inventor: HILL PATRICIA J [US]


Application No.: US20080293711A1  Published: 27/Nov/2008

Title: Chemokine receptor modulators

Applicant/Assignee:

Application No.: 12/073672   Filing Date: 07/Mar/2008

Abstract:The invention provides compounds of Formula (I) and pharmaceutical compositions comprising compounds of Formula (I). These compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers.

Priority: US20070905610P Applic. Date: 2007-03-08

Inventor: CLARK MICHAEL P [US]; LOCKWOOD MARK A [US]; WAGNER FLORENCE F [US]; NATCHUS MICHAEL G [US]; DOROH BRANDON C [US]


Application No.: US20080295960A1  Published: 04/Dec/2008

Title: Silicone Adhesive For Adhesion To Wet Surfaces

Applicant/Assignee:

Application No.: 12/158718   Filing Date: 03/Jan/2007

Abstract:A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups

(ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm2/s at 25 DEG C.

(iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm2/s at 25 DEG C.

(iv) a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000

and optionally, (v) a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds. Other components such as a silicone polyether, a silicone wax, a drug, an excipient, and/or an active ingredient can also be included.

Priority: US20060760254P Applic. Date: 2006-01-19; WO2007US00062 Applic. Date: 2007-01-03

Inventor: SCHALAU II GERALD KENNETH [US]; THOMAS XAVIER JEAN-PAUL [BE]; RAUL VICTOR ALBERT [US]; GANTNER DAVID CLAYTON [US]


Application No.: US20080299045A1  Published: 04/Dec/2008

Title: Composition for Prevention, Treatment, and Diagnosis of Chronic Obstructive Pulmonary Disease (Copd)

Applicant/Assignee:

Application No.: 11/883589   Filing Date: 03/Feb/2006

Abstract:The present invention provides a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease (COPD) comprising cytokeratin 18 protein as an active ingredient. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing COPD comprising cytokeratin 18 protein. The present invention further provides a composition for screening a therapeutic agent for COPD, comprising one or more of cytokeratin 18 protein or autoantibodies to cytokeratin 18 obtained from patients with COPD and a method for screening a therapeutic agent for COPD using this composition. The present invention still further provides methods for diagnosing, preventing or treating COPD using cytokeratin 18 protein.

Priority: KR20050010924 Applic. Date: 2005-02-05; KR20060010285 Applic. Date: 2006-02-02; WO2006KR00380 Applic. Date: 2006-02-03

Inventor: JEON SOOK-YEONG [KR]; NAM DONG-HO [KR]


Application No.: US20080299055A1  Published: 04/Dec/2008

Title: Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof

Applicant/Assignee: PIERRE FABRE DERMO-COSMETIQUE

Application No.: 11/579341   Filing Date: 04/May/2005

Abstract:The invention relates to the use of 5,6-diphenyl-1,2,4-triazinic compounds of general formula (I), wherein cycle penetrating bonds display an ortho, meta or para indifferent substitution position, identical or different R1 and R2 represent a hydrogen, fluoride, chloride or bromine atom, C1 to C12 linear or branched alkyl, C1 A C18 linear or branched hydroxy, alkoxy poly(ethoxy)-alkoxy with a C1 to C4 alkyl fragment and an ethoxy number ranging from 1 to 4, amino or mono or di-alkylamino with a C1 to C4 alkyl fragment group, R3 represents a chlorine atom, a hydroxy, amino, a phenyl possibly 1 to 3 times substituted by a hydroxy radical situated at least in a para or phenyl position possibly 1 to 3 times substituted in an ortho, meta or para position by a C1 to C12 alkoxy or cyano or alkymino group with a C1 to C7 alkyl fragment in the form of active sun filters or light-protective agents and to cosmetic composition containing said compounds.

Priority: FR20040004810 Applic. Date: 2004-05-05; WO2005FR01129 Applic. Date: 2005-05-04

Inventor: REY JEROME [FR]; BORDAT PASCAL [FR]; TARROUX ROGER [FR]


Application No.: US20080299057A1  Published: 04/Dec/2008

Title: Method and compositions for dispersing particulate solids in oil

Applicant/Assignee:

Application No.: 12/154890   Filing Date: 28/May/2008

Abstract:This invention relates to a method for preparing dispersions of solid particles, especially pigments, metal oxides and mineral fillers in organic media, to dispersing compositions used in this method and to dispersions containing these dispersion compositions. The dispersing compositions include an oil soluble surfactant selected from the group consisting of phospholipids, alkyl acids, nonionic surfactants having an HLB less than 10, and mixtures thereof

either an anhydride based polymer selected from the group consisting of polyalkene succinic anhydrides

maleinized polyisoprene

maleinized polybutadiene

maleinized copolymers of isoprene and butadiene

copolymers of styrene and maleic anhydride

derivatives formed by reaction of the anhydride group of the anhydride based polymer with one or more of water, amines, alcohols, and polyols

and mixtures thereof

or a mixture of the said anhydride based polymer with polyhydroxystearic acid

and optionally a liquid oil carrier.

Priority: US20070932165P Applic. Date: 2007-05-29

Inventor: LIN SAMUEL QCHENG SUN [US]


Application No.: US20080299058A1  Published: 04/Dec/2008

Title: Multi-formulation cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/156676   Filing Date: 04/Jun/2008

Abstract:The present invention relates to a cosmetic composition a) from about 10% to about 90% of water-in-oil emulsion as a first formulation which comprises i) from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer

ii) from about 1% to about 40% of a solvent for the emulsifying crosslinked siloxane elastomers

and iii) from about 40% to about 99% of an aqueous phase

and b) from about 10% to about 90% of a second formulation, wherein the first and second formulations are of different formulation, and wherein when shear stress is applied to the composition during spreading on skin, at least a part of the aqueous phase is released from the first formulation.

Priority: US20070933075P Applic. Date: 2007-06-04

Inventor: SAITO YUJIN [US]; TANAKA HIDEKAZU [JP]; HORIUCHI AYUMI [JP]


Application No.: US20080299062A1  Published: 04/Dec/2008

Title: Use of Oxocarboxylic Acids-Containing Combinations for Deodorization

Applicant/Assignee:

Application No.: 11/571774   Filing Date: 11/Jul/2005

Abstract:Described is the use of a combination of an oxocarboxylic acid with metal ions, organic bases or polymers substantive for keratin material for combating, suppressing or eliminating odors of the hair of skin. Preferred oxocarboxylic acids are those of general formula R-C(-O)-A-CO2H wherein R stands for hydrogen or a monovalent organic group and A strands for a divalent organic group or for a single bond. A preferred combination is zinc levulinate which can be used, in particular, for combating the unpleasant odors of sulfur compounds, for example after permanent wave treatments.

Priority: DE200410033206 Applic. Date: 2004-07-09; WO2005EP07485 Applic. Date: 2005-07-11

Inventor: KRIPP THOMAS [DE]; HARPE CAROLIN [DE]; KELLER WALTER [DE]; KISCHKA KARL-HEINZ [DE]


Application No.: US20080299067A1  Published: 04/Dec/2008

Title: Functionalised Siloxanes for Scar Tissue Treatment

Applicant/Assignee: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Application No.: 11/579378   Filing Date: 04/May/2005

Abstract:A novel composition for use in treating a wound, burn or other skin condition comprises one or more compounds of formula (I), wherein: m = 0-6, n = 6-100, Q, R and R' may be independently selected from, C1-5 alkyl, OU, UOCH2CH3, CH2CH3, UOCH3, OH, O(CH2)y(OU)yCH3, (OCH2CH2)yOU, (OCH2CH2)yOH, UOH, UOU', UCO2U', CO2U, UCO2COU, CO2H, UCO2H, COX, UCOX, UCO2 R', CO2COU, Aryl, ArylU, ArylUU, ArylUU'U'', NH2, UNH2, NHU, NUU', NO2, UNO2, UCONH2, CONH2, UCONHU', CONHU, UCONU'U'', CONU'U'', halogen, PO4H3, PO4H3-z, PO4H3-zU (z = 0, 1, 2 or 3), PU3, P U'U''U'''SH, SO2 and SO3H

wherein U, U', U'' and U''' may be independently selected from any alkyl, alkenyl or alkynyl group where the number of carbon atoms is between 1 and 31

wherein X=halogen

wherein y=1-100

provided that Q, R and R' can not all be C1 alkyl

and wherein the compound of formula (I) is present in an amount of at least 1% of the composition.

Priority: US20040568109P Applic. Date: 2004-05-04; WO2005AU00630 Applic. Date: 2005-05-04

Inventor: SANCHEZ WASHINGTON [AU]; GEORGE GRAEME ALLAN [AU]


Application No.: US20080299155A1  Published: 04/Dec/2008

Title: Color cosmetic compositions for topical anti-aging skin treatment

Applicant/Assignee: DISCOVERY PARNERS LLC

Application No.: 11/809981   Filing Date: 04/Jun/2007

Abstract:This invention discloses color cosmetic compositions and methods for anti-aging treatments that utilize plant-based copper antioxidant complexes.

Priority:

Inventor: MCCOOK JOHN PATRICK [US]; DOROGI PETER LADISLAUS [US]; VASILY DAVID BRUCE [US]; LYDIC DEBORAH LYNN [US]; ALLEN DAVID BLAIR [US]


Application No.: US20080299156A1  Published: 04/Dec/2008

Title: SKIN CARE COMPOSITIONS CONTAINING A HIGH INTERNAL PHASE EMULSION

Applicant/Assignee: L'OREAL

Application No.: 12/112337   Filing Date: 30/Apr/2008

Abstract:The present invention is directed to a skin care composition comprising (a) at least one high internal phase emollient-in-water emulsion

(b) at least one fatty compound, capable of forming a liquid crystal

(c) at least one thickening agent

(d) at least one active agent

and (e) water. Also disclosed is a method of treating skin with the above-disclosed skin care composition.

Priority: US20070941335P Applic. Date: 2007-06-01

Inventor: FARES HANI [US]; GUERRERO RITAMARIE [US]; HANSENNE ISABELLE [US]


Application No.: US20080299157A1  Published: 04/Dec/2008

Title: SKIN CARE COMPOSITIONS HAVING UNIQUE TEXTURE PROPERTIES

Applicant/Assignee: L'OREAL

Application No.: 12/112375   Filing Date: 30/Apr/2008

Abstract:The present invention is directed to a skin care composition comprising (a) at least one high internal phase emollient-in-water emulsion

(b) at least one thickening agent

(c) at least one primary emulsifier chosen from a water-in-silicone emulsifier

(d) at least one non-emulsifying silicone elastomer

(e) at least one active agent

and (f) water. Also disclosed is a method of treating skin with the above-disclosed skin care composition.

Priority: US20070941341P Applic. Date: 2007-06-01

Inventor: FARES HANI [US]; STRICKLAND JOHN D [US]; GUERRERO RITAMARIE [US]; HANSENNE ISABELLE [US]


Application No.: US20080299159A1  Published: 04/Dec/2008

Title: Anti-acne skin agent for external use

Applicant/Assignee: FUJIFILM CORPORATION

Application No.: 12/153856   Filing Date: 27/May/2008

Abstract:It is an object of the present invention to provide an anti-acne skin agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size, moisturizing properties, and high permeability into skin. The present invention provides an anti-acne skin agent for external use, which comprises protein nanoparticles containing an active ingredient.

Priority: JP20070144542 Applic. Date: 2007-05-31

Inventor: AIMI MAKIKO [JP]; OGIWARA KAZUTAKA [JP]


Application No.: US20080299166A1  Published: 04/Dec/2008

Title: NOVEL BIOMATERIALS, THEIR PREPARATION AND USE

Applicant/Assignee:

Application No.: 12/178934   Filing Date: 24/Jul/2008

Abstract:The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

Priority: EP20020008809 Applic. Date: 2002-04-19; US2005-511075 Applic. Date: 2005-03-17; WO2003EP04076 Applic. Date: 2003-04-17

Inventor: SZENTE LAJOS [HU]; SZEJTLI JOZSEF [HU]; KIS GYORGY L [CH]; SCHOCH CHRISTIAN [CH]


Application No.: US20080299168A1  Published: 04/Dec/2008

Title: Stabilized Polymeric Delivery System

Applicant/Assignee:

Application No.: 11/667433   Filing Date: 10/Nov/2005

Abstract:The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.

Priority: US20040626780P Applic. Date: 2004-11-10; WO2005US40855 Applic. Date: 2005-11-10

Inventor: DADEY ERIC [US]; ZHOU MINGXING [US]


Application No.: US20080299182A1  Published: 04/Dec/2008

Title: METHODS AND FORMULATIONS FOR TOPICAL GENE THERAPY

Applicant/Assignee:

Application No.: 12/040520   Filing Date: 29/Feb/2008

Abstract:Formulations of viral vectors for topical application are disclosed as well as methods for making the same. Also disclosed are methods of treating a subject or diagnosing disease in a subject using the formulations of the present invention.

Priority: US20070892427P Applic. Date: 2007-03-01

Inventor: ZHANG SHUYUAN [US]; ONISHI ERIC [US]


Application No.: US20080299220A1  Published: 04/Dec/2008

Title: HYDROPHILIC, NON-AQUEOUS PHARMACEUTICAL CARRIERS AND COMPOSITIONS AND USES

Applicant/Assignee:

Application No.: 12/014088   Filing Date: 14/Jan/2008

Abstract:A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25 DEG C.

and (ii) propylene glycol (PG)

about 0% to about 10% of at least one surface active agent

about 0% to about 5% of a polymeric agent

about 0% to about 30% of a secondary hydrophilic solvent

and about 0% to about 5% of a silicone oil

and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.

Priority: US2006-430599 Applic. Date: 2006-05-09; US2004-835505 Applic. Date: 2004-04-28; US2007-947751 Applic. Date: 2007-11-29; US2007-653205 Applic. Date: 2007-01-12; US2004-911367 Applic. Date: 2004-08-04; US20070880434P Applic. Date: 2007-01-12; US20070919303P Applic. Date: 2007-03-21; US20050679020P Applic. Date: 2005-05-09; US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04; US20060861620P Applic. Date: 2006-11-29; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]; SCHUZ DAVID [IL]; BERMAN TAL [IL]; DANZIGER JORGE [IL]; KEYNAN RITA [IL]; ZLATKIS ELLA [IL]


Application No.: US20080299228A1  Published: 04/Dec/2008

Title: TOPICAL COMPOSITIONS COMPRISING A MACROMOLECULE AND METHODS OF USING SAME

Applicant/Assignee:

Application No.: 12/129615   Filing Date: 29/May/2008

Abstract:Compositions, including those in which the active ingredient or agent is stable and capable of penetrating the sites of topical application are provided. The compositions can include a macromolecule, for example, a parathyroid hormone (PTH), a PTH-like hypercalcemic factor (CFF) or biologically active variant of a PTH or CFF in a vehicle comprising a polymer or cationic liposome. The compositions can also include other substances that further promote the stability of the active agent (e.g., buffers, antioxidants or carbohydrates). Also provided are methods for using the compositions for treatment of skin disorders (e.g., hyperproliferative skin disorders, including, but not limited to, for example, psoriasis, acne, rosacea or acne.)

Priority: US20070940509P Applic. Date: 2007-05-29

Inventor: HARRIS ALAN GERALD [US]; JOHNSON KEITH ARTHUR [US]; LUKIC TATJANA [US]


Application No.: US20080305055A1  Published: 11/Dec/2008

Title: Anti-Radical Agents

Applicant/Assignee:

Application No.: 11/792745   Filing Date: 24/Oct/2005

Abstract:Compounds of the formulae (1), (2) and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of formula (3), wherein Gi is hydrogen

C1-C22alkyl

C1-C22alkylthio

C2-C22alkylthioalkyl

C5-C7cycloalkyl

phenyl

C7-C9phenylalkyl

or SO3M

G2 is C1-C22alkyl

C5-C7cycloalkyl

phenyl

or C7-C9phenylalkyl

E is oxyl or hydroxyl

V is -O-

or -NH-

a is 0 or 1 or 2

b, c and d and g are each independently of one another 0 or 1

e is an integer from 1 to 4

f, m, n and p are each independently of one another an integer from 1 to 3

q is 0 or an integer from 1 to 3

Q, T and G3 are as defined in claim 1

G4 and G5 are each independently of the other hydrogen

or C1-C22alkyl

exhibit marked antiinflammatory action.

Priority: EP20040106821 Applic. Date: 2004-12-22; WO2005EP55475 Applic. Date: 2005-10-24

Inventor: BASCHONG WERNER [CH]; REICH OLIVER [DE]; MONGIAT SEBASTIEN [FR]


Application No.: US20080305056A1  Published: 11/Dec/2008

Title: STABLE, LOW VISCOSITY COSMETIC COMPOSITIONS

Applicant/Assignee: EVONIK GOLDSCHMIDT GMBH

Application No.: 12/132307   Filing Date: 03/Jun/2008

Abstract:The invention relates to a cosmetic composition for application to the skin, having: a) 0.05 to 0.5% by weight of a quaternized polysaccharide, 0.05 to 5.0% by weight of a polyethylene glycol derivative or polypropylene glycol derivative and/or 0.05 to 3% by weight of a polymeric quaternized ammonium compound ("polyquaternium"), b) 10 to 40% by weight of oils and/or oil-like constituents, and c) 0.2 to 15% by weight of an ester quat and/or of a dialkyl quat.

Priority: DE200710027030 Applic. Date: 2007-06-08

Inventor: JENNI KLAUS [DE]; MATHIAK RALF [DE]; VEEGER MARCEL [DE]; MEYER JURGEN [DE]


Application No.: US20080305058A1  Published: 11/Dec/2008

Title: Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and merocyanine sulfone compounds

Applicant/Assignee: L'OREAL

Application No.: 11/987111   Filing Date: 27/Nov/2007

Abstract:Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane compound UV-A sunscreen and at least one merocyanine sulfone compound.

Priority: FR20050051398 Applic. Date: 2005-05-27; WO2006EP05332 Applic. Date: 2006-05-15; US20050690502P Applic. Date: 2005-06-15

Inventor: RICHARD HERVE [FR]


Application No.: US20080305059A1  Published: 11/Dec/2008

Title: Skin lightening compositions and methods

Applicant/Assignee:

Application No.: 11/810626   Filing Date: 06/Jun/2007

Abstract:Skin lightening/even toning compositions are provided for reducing skin pigmentation of normal skin and for lightening hyper-pigmented skin said compositions comprising (i) highly purified hexylresorcinol which is substantially free or resorcinol, (ii) optionally, at least one other skin lightening agent, and (iii) a dermatologically acceptable carrier.

Priority:

Inventor: CHAUDHURI RATAN K [US]


Application No.: US20080305060A1  Published: 11/Dec/2008

Title: AQUEOUS-ALCOHOLIC DEPIGMENTING GELS

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/137384   Filing Date: 11/Jun/2008

Abstract:Stable, topically applicable cosmetic/pharmaceutical skin depigmenting compositions contain at least one phenolic compound, at least one retinoid and at least one corticoid, and are formulated as aqueous-alcoholic gels in topically applicable, physiologically acceptable media therefor.

Priority: US20050752593P Applic. Date: 2005-12-22; WO2006EP69611 Applic. Date: 2006-12-12; FR20050012564 Applic. Date: 2005-12-12

Inventor: LOUIS FABIENNE [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]


Application No.: US20080305075A1  Published: 11/Dec/2008

Title: Treatment of Hyperproliferative Diseases with Vinca Alkaloid N-Oxide and Analogs

Applicant/Assignee:

Application No.: 12/111672   Filing Date: 29/Apr/2008

Abstract:The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.

Priority: WO2007US04252 Applic. Date: 2007-02-20; US20060774204P Applic. Date: 2006-02-17

Inventor: CURD JOHN G [US]; KEANA JOHN F W [US]; LALANI ALSHAD S [US]; WESTBERG PAUL B [US]; GOODWIN BRADFORD [US]; HENNER W DAVID [US]


Application No.: US20080305082A1  Published: 11/Dec/2008

Title: 1,4-Bis-N-Oxide-5,8- Dihydroxyanthracenedione Compounds and the Use Thereof

Applicant/Assignee:

Application No.: 11/662599   Filing Date: 14/Sep/2005

Abstract:Disclosed are compounds having Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, A, and B are as defined herein, for use in methods for treating, preventing or ameliorating hyperproliferative disorders, such as cancer and other diseases and conditions. The invention also relates to pharmaceutical compositions and formulations comprising a compound having Formula I, and in combination with one or more other active agents and/or treatments.

Priority: US20040609253P Applic. Date: 2004-09-14; WO2005US32398 Applic. Date: 2005-09-14

Inventor: CURD JOHN G [US]; CAPIZZI ROBERT L [US]; KEANA JOHN F W [US]


Application No.: US20080305096A1  Published: 11/Dec/2008

Title: METHOD AND COMPOSITION FOR PROVIDING CONTROLLED DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES

Applicant/Assignee: UNICITY INTERNATIONAL, INC

Application No.: 11/759410   Filing Date: 07/Jun/2007

Abstract:A method of providing controlled release of a biologically active substance within a subject's digestive system. The biologically active substance is administered concurrently with one or more soluble fibers in an oral dosage unit. The soluble fibers interact with the biologically active substance within the subject's digestive system to moderate and control the release of the biologically active substances in the subject's bloodstream. This provides more constant blood concentrations of the biologically active substances. The amount of soluble fibers in the oral dosage unit is greater than 40% by weight, and in some cases greater than 50% by weight of the oral dosage unit. The oral dosage unit typically contains from about 1 to 15g of soluble fiber, and in some cases from about 3 to 5g of soluble fiber. The biologically active substance may contain phytonutrients that promote the subject's cardiovascular system, immune system, or weight management.

Priority:

Inventor: VERDEGEM PETER J E [US]; HUGHES STEWART F [US]; HEDGES CURTIS A [US]; BANGERTER G PAULO [US]


Application No.: US20080305106A1  Published: 11/Dec/2008

Title: Novel Gene Disruptions, Composition and Methods Relating Thereto

Applicant/Assignee:

Application No.: 11/568901   Filing Date: 12/Apr/2005

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20040571347P Applic. Date: 2004-05-12; WO2005US12478 Applic. Date: 2005-04-12

Inventor: BRENNAN JANE [GB]; DE SAUVAGE FREDERIC J [US]; FILVAROFF ELLEN [US]; GREWAL IQBAL [US]; IRVING BRYAN [US]; JUNUTULA JAGATH REDDY [US]; KIRCHHOFER DANIEL [US]; PEALE FRANKLIN [US]; PHILLIPS HEIDE [US]; TANG TRACY [US]; WICKRAMASINGHE DINELI [US]; YE WEILAN [US]


Application No.: US20080305121A1  Published: 11/Dec/2008

Title: Agents for Regulating the Activity of Interferon-Producing Cells

Applicant/Assignee: GINKGO BIOMEDICAL RESEARCH INSTITUTE CO., LTD

Application No.: 11/629045   Filing Date: 06/Sep/2005

Abstract:The present invention provides agents for regulating the activity of interferon-producing cells (IPCs), which comprise as active ingredients antibodies that bind to BST2 and/or to its homologues, and methods for regulating IPC activity that use these antibodies. According to the present invention, the ability of IPCs to produce interferons (IFNs) and the number of cells can be directly regulated. The present invention also provides uses of BST2 and/or its homologues as markers for IPC activation. Compounds that regulate IPC activation can be screened using the markers for IPC activation.

Priority: JP20040173767 Applic. Date: 2004-06-11; WO2005JP10561 Applic. Date: 2005-06-09

Inventor: OHKAWA JUN [JP]; KAMOGAWA YUMIKO [JP]


Application No.: US20080305154A1  Published: 11/Dec/2008

Title: Transdermal medicament patch and active electrode for same

Applicant/Assignee: ACTIVATEK, INC

Application No.: 11/811241   Filing Date: 08/Jun/2007

Abstract:A transdermal medicament patch includes a biocompatible substrate having a therapeutic face on one side configured for disposition against the skin of a patient, a biocompatible adhesive on the therapeutic face, a planar medicament matrix covering a portion of the therapeutic face, and a release liner covering the portion of therapeutic that is not obscured by the medicament matrix. An aperture formed through the release sheet affords direct access by medicament to the entire surface of the medicament matrix opposite from the therapeutic face of the substrate. An active electrode positioned between the medicament matrix and the therapeutic face of the substrate includes an electrically conductive backing layer positioned against the therapeutic face of the substrate and a pH-control layer covering less than all of the side of the backing layer opposite from the therapeutic face of the substrate. One active electrode design criterion relates the relative size of the pH-control layer to the size of the backing layer

another relates the size of portion of the area of the backing layer that is free of the pH-control lawyer to the size of the pH-control layer. The pH-control layer is made of an electrically conductive material capable of moderating changes in the hydrogen-ion concentration in the medicament matrix during iontophoretic current flow. An electrical contact electrically coupled through the substrate to the backing layer includes a hollow, electrically conductive snap fitting having an open end and a cooperating stud that is inserted into the open end of the snap.

Priority:

Inventor: YANAKI JAMAL S [US]


Application No.: US20080305155A1  Published: 11/Dec/2008

Title: Transdermal Systems Containing Multilayer Adhesive Matrices to Modify Drug Delivery

Applicant/Assignee: MYLAN TECHNOLOGIES, INC

Application No.: 12/057728   Filing Date: 28/Mar/2008

Abstract:A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally

a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug

a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile

and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Priority: US2004-795584 Applic. Date: 2004-03-09

Inventor: JACKSON KRISTIN [US]; MILLER II KENNETH JAMES [US]


Application No.: US20080305193A1  Published: 11/Dec/2008

Title: Cosmetic compositions

Applicant/Assignee:

Application No.: 11/809947   Filing Date: 05/Jun/2007

Abstract:A cosmetic composition suitable for topical application to human or animal skin comprising an effective amount of active ingredient dispersed in an acceptable cosmetic base or carrier, wherein the active ingredient comprises a mixture of an amino acid, a low glycemic glycoside and a Vitamin, wherein the amino acid is L-arginine, and wherein the low glycemic glycoside is derived from kiwi fruit.

Priority:

Inventor: DUPREY JR JAMES R [US]


Application No.: US20080305989A1  Published: 11/Dec/2008

Title: Transdermal delivery peptides and method of use thereof

Applicant/Assignee: NOVOMED TECHNOLOGIES, INC. (SHANGHAI) UNIVERSITY OF SCIENCE & TECHNOLOGY OF CHINA

Application No.: 11/531879   Filing Date: 14/Sep/2006

Abstract:Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, including the improvement of transdermal delivery of drugs or other pharmaceutically active agents, are also disclosed. Nucleic acids, expression vectors, and methods of their use, which encode the transdermal delivery peptides are disclosed. Methods are also provided for in vivo phage display for identifying further peptides with enhanced transdermal delivery capability.

Priority: US20050717497P Applic. Date: 2005-09-15; US20050740613P Applic. Date: 2005-11-29

Inventor: WEN LONG-PING [CN]; CHEN YONGPING [CN]; SHEN YUANYUAN [CN]; GUO XIN [CN]; WANG WEIPING [CN]; ZHANG BRIAN [US]


Application No.: US20080306025A1  Published: 11/Dec/2008

Title: N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/194203   Filing Date: 19/Aug/2008

Abstract:The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine.

Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.

Priority: US2007-621287 Applic. Date: 2007-01-09; US20060757614P Applic. Date: 2006-01-10

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]


Application No.: US20080306103A1  Published: 11/Dec/2008

Title: METHODS AND COMPOSITIONS FOR TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS AND NOVEL COMPOUNDS USEFUL THEREFOR

Applicant/Assignee: ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

Application No.: 12/138261   Filing Date: 12/Jun/2008

Abstract:There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

Priority: US2005-512673 Applic. Date: 2005-07-08; WO2003IL00357 Applic. Date: 2003-05-01; US20020377433P Applic. Date: 2002-05-03

Inventor: FISHER ABRAHAM [IL]; BAR-NER NIRA [IL]; KARTON YISHAI [IL]


Application No.: US20080311053A1  Published: 18/Dec/2008

Title: Fluorinated phosphate ester surfactant and fluorinated alcohol compositions

Applicant/Assignee: MASON CHEMICAL COMPANY

Application No.: 12/157618   Filing Date: 12/Jun/2008

Abstract:Foaming compositions having high solvent content and compositions for foaming high solvent content formulations are disclosed having a fluorinated phosphate ester surfactant ("FPES") of the formula (Ra-O)x-P(O)-(ORb)y in combination with a fluorinated alcohol ("FA") of the formula RcOH, where x is 1 to 3, y is (3-x), Ra is a group R1-R2- with R1 being a fluorinated C6-18hydrocarbon optionally interrupted by groups of one or two non-fluorinated (or less fluorinated) carbons per interruption, and/or optionally interrupted by heteroatoms or functional groups, and Rb is selected from H and positively charged amines, and Rc is the same or different as Ra and if different is selected from the same group of Ra materials as well as from analogous groups to Ra except that they have only 1-3 carbons in the R1 portion of Ra instead of the Ra requirement of at least 4 carbons. The ratio of FA to FPES is at least 5% FA to not more than 95% FPES based on the total FA+FPES weight. The compositions are especially useful for foaming high organic solvent content (>20% by weight solvent) with the solvent being selected from lower aliphatic alcohol, C5-6cyclic saturated or unsaturated alcohols, lower alkyl-C(O)-lower alkyl, lower alkyl-O-C(O)-lower alkyl, lower alkylene glycols, and lower alkylene glycol-mono lower alkyl ethers.

Priority: US20070934632P Applic. Date: 2007-06-14

Inventor: CURTIS MICHAEL ALLEN [US]


Application No.: US20080311059A1  Published: 18/Dec/2008

Title: COMPOSITION FOR SKIN CARE AND METHOD FOR THE SAME

Applicant/Assignee: NATIONAL APPLIED RESEARCH LABORATORIES TAIPEI MEDICAL UNIVERSITY

Application No.: 11/857158   Filing Date: 18/Sep/2007

Abstract:A skin whitening composition and a method for the same are provided. The skin whitening composition comprises a far-infrared ray releasing substance having a primary component of an oxide mineral, wherein the skin whitening composition achieves a whitening effect via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of administering a far-infrared ray releasing substance to a subject and reducing melanogenesis of the subject by inhibiting growth of a pigment cell, wherein the far-infrared releasing substance has an oxide mineral.

Priority: TW20070121948 Applic. Date: 2007-06-15; TW20070121951 Applic. Date: 2007-06-15

Inventor: LIN YUNG-SHENG [TW]; LIN MING-YU [TW]; HUANG TSUNG-TAO [TW]; LEUNG TING-KAI [TW]; SHIH CHWEN-MING [TW]


Application No.: US20080311100A1  Published: 18/Dec/2008

Title: Treatment of Keratinous Dryness With Glycerides

Applicant/Assignee: LABORATOIRES INNEOV

Application No.: 11/920259   Filing Date: 15/May/2006

Abstract:The present invention provides the use of medium chain glyceride(s) as an active ingredient for the preparation of a composition for oral and/or parenteral absorption and intended to prevent and/or treat dry and/or delicate keratinous substances.

Priority: FR20050051264 Applic. Date: 2005-05-16; US20050754214P Applic. Date: 2005-12-28; WO2006FR50445 Applic. Date: 2006-05-15

Inventor: MANISSIER PATRICIA [FR]; MONTASTIER CHRISTIANE [FR]; PICCIRILLI ANTOINE [FR]


Application No.: US20080311107A1  Published: 18/Dec/2008

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant/Assignee: GENETECH, INC

Application No.: 11/814136   Filing Date: 09/Feb/2007

Abstract:The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders

cardiovascular, endothelial or angiogenic disorders

eye abnormalities

immunological disorders

oncological disorders

bone metabolic abnormalities or disorders

lipid metabolic disorders

or developmental abnormalities.

Priority: US20060774895P Applic. Date: 2006-02-17; WO2007US61927 Applic. Date: 2007-02-09

Inventor: BOLLINGER KRISTI RAE [US]; COMBS KATHERIN E [US]; CUNNINGHAM JAIME-JO [US]; CULBERTSON LING LING [US]; DE SAUVAGE FREDERIC J [US]; EDWARDS JOEL A [US]; GREEN LESLIE JANE [US]; GIRGIS ROSEMARY [US]; HORNER ALLISON ANNE BYERS [US]; MCLAIN DINA REBECCA [US]; MONTGOMERY CHARLES [US]; MINZE LAURIE JEANETTE [US]; PAYNE BOBBY JOE [US]; PHILLIPS HEIDI [US]; SEVAUX TRAC ELLEN WILLIS [US]; SHI ZHENG-ZHENG [US]; SPARKS MARY JEAN [US]; STALA JOY ANNE [US]; TANG TRACY TZU-LING [US]; TOWNSEND TERESA GAIL [US]; VOGEL PETER [US]


Application No.: US20080311167A1  Published: 18/Dec/2008

Title: Topical Composition for Treating Pain

Applicant/Assignee:

Application No.: 11/851241   Filing Date: 06/Sep/2007

Abstract:Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as "lipophilic vehicle" or "LV" and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays

needles or catheters

adult diapers

gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

Priority: US20070943552P Applic. Date: 2007-06-12

Inventor: ORONSKY BRYAN T [US]; ORONSKY NEIL C [US]; ORONSKY ARNOLD L [US]


Application No.: US20080311216A1  Published: 18/Dec/2008

Title: Epidermal Growth Factor Composition, A Process Therefor and Its Application

Applicant/Assignee: BHARAT BIOTECH INTERNATIONAL LIMITED

Application No.: 11/915727   Filing Date: 18/May/2006

Abstract:A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, carrier/diluent, and optionally pH regulating agent and humectant.

Priority: IN2005CH00642 Applic. Date: 2005-05-27; WO2006IN00168 Applic. Date: 2006-05-18

Inventor: ELLA KRISHNA MURTHY [IN]; VELLIMEDU SRINIVAS KANNAPPA [IN]


Application No.: US20080312118A1  Published: 18/Dec/2008

Title: HARD SURFACE CLEANING COMPOSITION WITH HYDROPHILIZING AGENT AND METHOD FOR CLEANING HARD SURFACES

Applicant/Assignee: RHODIA INC

Application No.: 12/137738   Filing Date: 12/Jun/2008

Abstract:A composition for cleaning or rinsing hard surfaces in an aqueous or aqueous/alcoholic medium including at least one organophosphorus material for contributing to said surfaces antideposition and/or antiadhesion properties with regard to soiling substances capable of being deposited on the surfaces.

Priority: US20070943517P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES [SG]; HOUGH LAWRENCE ALAN [US]; REIERSON ROBERT LEE [US]


Application No.: US20080312129A1  Published: 18/Dec/2008

Title: Use of Mas G-Protein-Coupled Receptor Agonists and Antagonists, as Apoptotic-Activity Modulators for Study, Prevention and Treatment of Diseases

Applicant/Assignee:

Application No.: 11/922949   Filing Date: 28/Jun/2006

Abstract:The present invention is characterized by the use of Mas G-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study, prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G-protein-coupled receptor agonists and antagonists, including the Ang-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non-embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitative. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.

Priority: BR2005PI02497 Applic. Date: 2005-06-28; WO2006BR00125 Applic. Date: 2006-06-28

Inventor: SOUZA DOS SANTOS ROBSON AUGUSTO [BR]; VELOSO BRANT PINHEIRO SERGIO [BR]; DE FARIA E SILVA RAPHAEL [BR]; SILVA LULA IVANA [BR]; BARROS DE SOUSA FREDERICO [BR]; FREZARD FREDERIC JEAN GEORGES [BR]; DOS REIS ADELINA MARTHA [BR]; DE FRANCA LUIZ RENATO [BR]; FERREIRA ANDERSON JOSE [BR]; SINISTERRA RUBERT DARIO [BR]; CAMPAGNOLE SANTOS MARIA JOSE [BR]; DE OLIVEIRA SAMPAIO WALKYRIE N [BR]; DE CASTRO LEAL MARCELO [BR]


Application No.: US20080312181A1  Published: 18/Dec/2008

Title: Composition and Methods for Skin Care

Applicant/Assignee:

Application No.: 11/914093   Filing Date: 10/May/2006

Abstract:Compositions useful in the treatment of skin atrophy and improvement of skin appearance and texture are disclosed. The methods include the topical administration of vitamin D3 or specific vitamin D3 analogs as an essential ingredient either on its own or in combination with cADPR and or nicotinamide. The compositions are particularly effective in preventing and treating signs of chronological and or photoaging including fine lines, wrinkles and discoloration.

Priority: US20050679329P Applic. Date: 2005-05-10; WO2006IL00552 Applic. Date: 2006-05-10

Inventor: HAREL AVIKAM [IL]; EVEN-CHEN ZEEV [IL]; BLOCH OLGA [IL]


Application No.: US20080312234A1  Published: 18/Dec/2008

Title: NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 11/829531   Filing Date: 27/Jul/2007

Abstract:This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1

VR1

TRPV1) antagonist

and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Priority: EP20060015724 Applic. Date: 2006-07-27; EP20060020620 Applic. Date: 2006-09-29; EP20070004194 Applic. Date: 2007-02-28; US20070893974P Applic. Date: 2007-03-09

Inventor: KIM SUN-YOUNG [KR]; KIM JIN KWAN [KR]; LEE KI-WHA [KR]; WOO BYOUNG YOUNG [KR]; SHIN SONG SEOK [KR]; MOH JOO-HYUN [KR]; KIM SUNG-IL [KR]; JEONG YEON SU [KR]; LIM KYUNG MIN [KR]; CHOI JIN KYU [KR]; HA JUN YONG [KR]; KOH HYUN-JU [KR]; PARK YOUNG-HO [KR]; SUH YOUNG-GER [KR]; KIM HEE-DOO [KR]; PARK HYEUNG-GEUN [KR]; OH UH TAEK [KR]


Application No.: US20080312341A1  Published: 18/Dec/2008

Title: MONO-, DI- AND POLYOL PHOSPHATE ESTERS IN PERSONAL CARE FORMULATIONS

Applicant/Assignee: RHODIA INC

Application No.: 12/137589   Filing Date: 12/Jun/2008

Abstract:A hydrophilized personal care formulation, which can be in the form of a hand or body soap (liquid or bar), lipstick, body wash, makeup remover, skin cleaner, hair conditioner, skin or hair moisturizer. The formulation employs an organophosphorus material or a mixture of an organophosphorus material, for example, mono-, di-, and polyol phosphate esters.

Priority: US20070943487P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES [SG]; HOUGH LAWRENCE ALAN [US]; REIERSON ROBERT LEE [US]


Application No.: US20080312572A1  Published: 18/Dec/2008

Title: Absorbent Article for Application to Human or Animal Skin Surfaces

Applicant/Assignee:

Application No.: 12/091969   Filing Date: 31/Oct/2006

Abstract:The invention relates to an absorbent article for application to human or animal skin surfaces in the region of wounds, consisting of an outer covering (2) which is permeable for liquid substances, and of an inner layer (1) which is surrounded by the covering (2) and which consists essentially of a mixture of an amount of strongly osmotically active substances with an amount of osmotically comparatively weak or osmotically inactive substances, such as cellulose. The inner layer (1) is filled with osmotically active substances in such a way that it is possible to exert on a wound, with the wound fluids contained therein, an osmotic pressure via which the wound fluid can be removed from the organism to be treated, and thus it is possible to assist both in the surfaced wound region and in the depth of the tissue a normal interstitial hydration of tissue by directing endogenous fluids in their direction of flow to the patient's skin surface into the absorbent article, and keeping them there.

Priority: DE200520017211U Applic. Date: 2005-11-02; WO2006EP10482 Applic. Date: 2006-10-31

Inventor: RIESINGER BIRGIT [DE]


Application No.: US20080312579A1  Published: 18/Dec/2008

Title: METHOD AND SYSTEM FOR MITIGATING CURRENT CONCENTRATION IN ELECTROKINETIC DRUG DELIVERY

Applicant/Assignee: TRANSPORT PHARMACEUTICALS, INC

Application No.: 12/139873   Filing Date: 16/Jun/2008

Abstract:An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode

a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.

Priority: US20080033608P Applic. Date: 2008-03-04; US20070944134P Applic. Date: 2007-06-15

Inventor: CHANG KUOWEI [US]; GOLDBERG DENNIS I [US]; ETHEREDGE ROBERT W [US]; BARSNESS MICHAEL S [US]


Application No.: US20080312580A1  Published: 18/Dec/2008

Title: CURRENT CONCENTRATION SYSTEM AND METHOD FOR ELECTROKINETIC DELIVERY OF MEDICAMENTS

Applicant/Assignee: TRANSPORT PHARMACEUTICALS, INC

Application No.: 12/139936   Filing Date: 16/Jun/2008

Abstract:An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail.

Priority: US20070944126P Applic. Date: 2007-06-15

Inventor: BARSNESS MICHAEL S [US]; ETHEREDGE ROBERT W [US]; GOLDBERG DENNIS I [US]; CHAKRABORTY BIRESWAR [US]; DAVIS SHAWN P [US]


Application No.: US20080317679A1  Published: 25/Dec/2008

Title: FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES

Applicant/Assignee: FOAMIX LTD

Application No.: 11/767442   Filing Date: 22/Jun/2007

Abstract:The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor

and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water

a hydrophilic solvent

a hydrophobic solvent

a potent solvent

a polar solvent, a silicone, an emollient, and mixtures thereof

ii. 0% to about 48% of a secondary solvent selected from the group consisting of water

a hydrophilic solvent

a hydrophobic solvent

a potent solvent

a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof

iii. a surface-active agent

iv. about 0% to about 5% by weight of at least one polymeric agent

and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition

wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam

and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US2004-835505 Applic. Date: 2004-04-28; US2006-430437 Applic. Date: 2006-05-09; US2006-430599 Applic. Date: 2006-05-09; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21; US20030530015P Applic. Date: 2003-12-16; US20060815948P Applic. Date: 2006-06-23

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; BERMAN TAL [IL]; BESONOV ALEX [IL]


Application No.: US20080317680A1  Published: 25/Dec/2008

Title: Sunless tanning composition and method of sunless tanning

Applicant/Assignee: PLAYTEX PRODUCTS, INC

Application No.: 12/154524   Filing Date: 23/May/2008

Abstract:A sunless tanning composition having dihydroacetone and an amphoglycinate (amphoacetate) in an amount effective for sunless tanning is provided. Also provided is a method of sunless tanning having the step of topically applying to the skin an effective amount of a sunless tanning composition having dihydroacetone and an amphoglycinate.

Priority: US2005-174044 Applic. Date: 2005-07-01

Inventor: DUEVA-KOGANOV OLGA [US]; RUSSO THOMAS [US]; SANOGUEIRA JAMES [US]


Application No.: US20080317685A1  Published: 25/Dec/2008

Title: Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and siloxane-containing arylalkyl benzoate amide compounds

Applicant/Assignee: L'OREAL

Application No.: 11/987110   Filing Date: 27/Nov/2007

Abstract:Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane sunscreen compound and at least one photostabilizing siloxane-containing arylalkyl amide compound of formula (I) below:

Priority: FR20060055121 Applic. Date: 2006-11-27; US20060873565P Applic. Date: 2006-12-08

Inventor: CANDAU DIDIER [FR]; MULLER BENOIT [FR]; RICHARD HERVE [FR]


Application No.: US20080317690A1  Published: 25/Dec/2008

Title: Film-Forming Resins as a Carrier for Topical Application of Pharmacologically Active Agents

Applicant/Assignee:

Application No.: 12/091043   Filing Date: 07/Nov/2006

Abstract:The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

Priority: US20050734608P Applic. Date: 2005-11-07; WO2006US43572 Applic. Date: 2006-11-07

Inventor: BATTAGLIA ALEX [US]


Application No.: US20080317694A1  Published: 25/Dec/2008

Title: Deodorizing Preparations

Applicant/Assignee: COGNIS DEUTSCHLAND GMBH & CO. KG

Application No.: 12/202990   Filing Date: 02/Sep/2008

Abstract:A deodorizing composition containing: (a) from about 10 to 30% by weight of a dialkyl carbonate corresponding to formula I: wherein R1 is a linear alkyl and/or alkenyl group containing from about 6 to 22 carbon atoms, a 2-ethylhexyl, an isotridecyl, an isostearyl group or a group derived from a polyol containing 2 to 15 carbon atoms and at least two hydroxyl groups

R2 has the same meaning as R1 or is an alkyl group containing from about 1 to 5 carbon atoms

and n and m, independently of one another, represent a number up to 100, and (b) an antiperspirant.

Priority: DE20001002643 Applic. Date: 2000-01-21; US2002-181641 Applic. Date: 2002-07-19; WO2001EP00321 Applic. Date: 2001-01-12

Inventor: BRUENING STEFAN [DE]; GONDEK HELGA [DE]; ANSMANN ACHIM [DE]


Application No.: US20080317733A1  Published: 25/Dec/2008

Title: Cosmeceutical Compositions and Methods with Biologically Active Ingredients

Applicant/Assignee: NUGENE INC

Application No.: 11/766027   Filing Date: 20/Jun/2007

Abstract:Cosmeceutical formulations are personalized to address an individual's nutrient deficiencies and genetic predispositions for premature aging of the skin. Growth factors and high doses of inefficiently absorbed nutrients are nanoencapsulated and delivered topically to improve the function, health, and appearance of skin and hair.

Priority:

Inventor: AZIMI NAZLI [US]


Application No.: US20080317734A1  Published: 25/Dec/2008

Title: NUTRACEUTICAL COMPOSITIONS AND METHODS WITH BIOLOGICALLY ACTIVE INGREDIENTS

Applicant/Assignee: NUGENE INC

Application No.: 11/766036   Filing Date: 20/Jun/2007

Abstract:Nutraceutical formulations are personalized to address an individual's nutrient deficiencies. Growth factors and high doses of inefficiently absorbed nutrients are nanoencapsulated and delivered orally to improve the function, health, and appearance of the individual.

Priority:

Inventor: AZIMI NAZLI [US]; KHARAZMI MOHAMMAD SAEED [US]


Application No.: US20080317795A1  Published: 25/Dec/2008

Title: HIGHLY CHARGED MICROCAPSULES

Applicant/Assignee:

Application No.: 12/125035   Filing Date: 21/May/2008

Abstract:The invention encompasses compositions containing sol-gel microcapsules that are highly positively charged. The sol-gel capsules generally contain additives. The invention also encompasses methods for producing highly charged microcapsules using cationic additives which can include cationic polymers. The methods allow for the encapsulation of polar or non-polar active ingredients.

Priority: US20070939318P Applic. Date: 2007-05-21

Inventor: TRAYNOR DANIEL HENRY [US]; TRAYNOR HENRY G [US]; MARKOWITZ STEVEN M [US]; COMPTON DAVID L [US]


Application No.: US20080317830A1  Published: 25/Dec/2008

Title: Compositions and Methods for the Treatment of Wounds and Scar Tissue

Applicant/Assignee: LIOLABS LLC

Application No.: 11/768053   Filing Date: 25/Jun/2007

Abstract:Compositions for the treatment of wounds and/or scars are described herein. The compositions contain between 1 and up to 30% by weight, more preferably between 1 and 20%, most preferably between about 5 and 10% by weight particles, such as titanium dioxide or a similar material in a pharmaceutically acceptable base or carrier, such as petrolatum. The compositions are less greasy than petrolatum alone, and thus are more aesthetically pleasing. The compositions exhibit occlusive properties comparable to petrolatum. The compositions are absorbed into the skin, unlike petrolatum, and exhibit significant wound healing characteristics not observed with petrolatum alone. In one embodiment, the pharmaceutically acceptable base is petrolatum and the particles are titanium dioxide. The compositions can be used to treat complex, hard to heal wounds, such as diabetic ulcers

pressure sores, such as bed sores

lacerations

bite wounds

burns

penetrating wounds

surgical wounds, etc. The composition can also be used to promote normal healing of scar tissue. The compositions can also be used for the topical delivery of one or more active agent. The compositions can be used to reduce fine lines and wrinkles, and to rehydrate skin or to treat dry skin.

Priority:

Inventor: GOLDSTEIN JAY A [US]; GRUBSTEIN BERNARD [US]; ROTHMAN MICHAEL [US]; LO WHE-YONG [US]; PABST PATREA L [US]


Application No.: US20080317836A1  Published: 25/Dec/2008

Title: Topical compositions for anti-aging skin treatment

Applicant/Assignee: DISCOVERY PARTNERS LLC

Application No.: 11/820426   Filing Date: 19/Jun/2007

Abstract:This invention discloses anti-aging skin treatment compositions and methods that utilize plant-based copper and zinc antioxidant complexes.

Priority:

Inventor: DOROGI PETER LADISLAUS [US]; MCCOOK JOHN PATRICK [US]; VASILY DAVID BRUCE [US]


Application No.: US20080317850A1  Published: 25/Dec/2008

Title: Buccal Delivery System

Applicant/Assignee:

Application No.: 11/910902   Filing Date: 07/Apr/2006

Abstract:A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients

(b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix

(c) 0.05-2% by weight of the total matrix of one or more suspending agents

(d) 0.05-2% by weight of the total matrix of one or more flowing agents

and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.

Priority: AU20050901758 Applic. Date: 2005-04-08; WO2006AU00472 Applic. Date: 2006-04-07

Inventor: HEWITT ERNEST ALAN [AU]; STENLAKE RICHARD JAMES [AU]


Application No.: US20080317856A1  Published: 25/Dec/2008

Title: Compositions Containing A Capillary -Active System With Application -Relevant Differentiability, And The Use Thereof

Applicant/Assignee:

Application No.: 11/659393   Filing Date: 26/Jul/2005

Abstract:This invention relates to compositions with a capillary-active system with application-relevant differentiability and synergistic potential for use in mammals, especially humans. The invention accordingly relates to a composition that has a capillary-active system C optionally containing a capillary activator system CA consisting of drugs that increase blood flow, stabilize the vascular wall, and/or dilate the blood vessels

and/or a capillary-protective system CP comprising drugs for endothelial stabilization, lipoprotein protection, and for stabilization of leukocytes/platelets

and/or a capillary energy supply system CE comprising redox systems and cofactors in energy provision and energy carriers. This system C is combined with a selective action system S. The invention also relates to the use of such compositions, in particular systemically or enterally, especially for the selective control, for example, of structural changes, functional disturbances of the target organs in question (hair, skin, cerebrum, skeleton, muscles, gastrointestinal tract, eyes) as supplements (food supplements, supplementary balanced diet, dietary components), or pharmaceutical agents.

Priority: DE200410041270 Applic. Date: 2004-08-26; WO2005EP08087 Applic. Date: 2005-07-26

Inventor: BEUTLER ROLF D [DE]; SCHMIDT KARL-HEINZ [DE]; FUNKE BETTINA [DE]; BECKER KIRSTIN [DE]


Application No.: US20080317889A1  Published: 25/Dec/2008

Title: Liquid compositions containing solubilized benzoyl peroxide, devices for application of same and methods of treatment using same

Applicant/Assignee:

Application No.: 11/820949   Filing Date: 21/Jun/2007

Abstract:Liquid medicaments incorporate about 1.0-3.0% active benzoyl peroxide (BP) by weight in substantially fully solubilized form, while being substantially free of acetone and other harsh, dermatologically undesirable solvents. The novel compositions are produced by (a) creating an emulsion or slurry of BP in an emollient, topically acceptable ester, and (b) dissolving the emulsion or slurry in absolute alcohol. The medicaments may be used in the treatment of BP-responsive skin conditions in mammals, e.g., acne vulgaris or rosacea. The novel medicaments may be dispensed directly to the affected skin area through the use of an applicator device comprising a fluid reservoir associated with a foam applicator tip, or via a spray dispenser, atomizer or pump spray.

Priority:

Inventor: BLACKMAN STEVEN T [US]


Application No.: US20080318842A1  Published: 25/Dec/2008

Title: Cyclic Isodityrosine Derivatives

Applicant/Assignee:

Application No.: 11/791088   Filing Date: 30/Sep/2005

Abstract:[Problems] To provide a novel cyclic isodityrosine derivative having a physiological effect. [Means for solving problems] A compound represented by general formula (I) or a pharmacologically acceptable salt thereof has an effect of potentiating activity of imipenem, an effect of inhibiting the synthesis of a cholesteryl ester, and so forth: wherein R1 represents a hydrogen atom, an amido group, a Boc group, a Cbz group, an Fmoc group, a BocNH(CH2)5CO- group, a BocNHCH(CH2C6H5)CO- group, or a linear or branched alkyl group

R2 represents a benzoyl group, a benzyl group, a modified benzyl group, or a linear or branched alkyl group

R3 represents a hydrogen group, an -OR5 group, wherein R5 represents a linear or branched alkyl group or an aromatic ring, or an amido group

R4 represents a hydrogen atom, or a linear or branched alkyl group

and X1 and X2 each represent a halogen atom, wherein X1 and X2 may be the same as or different from each other.

Priority: JP20040336698 Applic. Date: 2004-11-19; WO2005JP18182 Applic. Date: 2005-09-30

Inventor: NISHIYAMA SHIGERU [JP]; OBATA RIKA [JP]; TOMODA HIROSHI [JP]


Application No.: US20080319001A1  Published: 25/Dec/2008

Title: Cancer Treatment Using Specific 3,6,9-Substituted Acridines

Applicant/Assignee:

Application No.: 11/886128   Filing Date: 02/Mar/2006

Abstract:The present invention relates to a 3,6,9 acridine compound and optionally substituted derivatives thereof that may be useful in the treatment of cancer. The invention also provides compositions comprising the compounds and uses thereof. Formula (I) wherein each of R1, R2, R3, R4 and R5 is either fluorine or is not present (i.e. represents a hydrogen atom)

n represents 1 or 2.

Priority: GB20050005045 Applic. Date: 2005-03-11; WO2006GB00740 Applic. Date: 2006-03-02

Inventor: MARTINS CHRISTINA [GB]; NEIDLE STEPHEN [GB]; GUNARATNAM MEKALA [GB]; STUART JOHN [GB]; KELLAND LLOYD [GB]


Application No.: US20080319050A1  Published: 25/Dec/2008

Title: Preparation Containing Oxidized Flavonoid Derivatives

Applicant/Assignee:

Application No.: 11/719712   Filing Date: 02/Nov/2005

Abstract:The invention relates to novel compositions, in particular cosmetic and/or pharmaceutical compositions or food supplements, comprising at least one oxidised flavonoid derivative of the formula I, to novel oxidised flavonoid derivatives, and to novel uses of the oxidised flavonoid derivatives.

Priority: DE200410055932 Applic. Date: 2004-11-19; WO2005EP11687 Applic. Date: 2005-11-02

Inventor: CAROLA CHRISTOPHE [DE]; HUBER SYLVIA [DE]; BUCHHOLZ HERWIG [DE]


Application No.: US20080319066A1  Published: 25/Dec/2008

Title: Jasmonate Derivative Compounds, Pharmaceuticals Compounds and Methods of Use Thereof

Applicant/Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD

Application No.: 12/198559   Filing Date: 26/Aug/2008

Abstract:The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.

Priority: US2007-581546 Applic. Date: 2007-02-23; WO2004IL01098 Applic. Date: 2004-12-01; US20030526081P Applic. Date: 2003-12-02

Inventor: FLESCHER ELIEZER [IL]; KASHMAN YOEL [IL]; REISCHER DORIT [IL]; SHIMONY SHIRI [IL]


Application No.: US20080319071A1  Published: 25/Dec/2008

Title: Novel Nutraceutical and Pharmaceutical Compositions and Use Thereof for the Treatment, Co-Treatment or Prevention of Inflammatory Disorders

Applicant/Assignee:

Application No.: 12/279510   Filing Date: 13/Feb/2007

Abstract:The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Priority: EP20060003162 Applic. Date: 2006-02-16; WO2007EP01241 Applic. Date: 2007-02-13

Inventor: RAEDERSTORFF DANIEL [FR]; SCHWAGER JOSEPH [CH]; SCHUELER GOEDE [DE]


Application No.: US20080319370A1  Published: 25/Dec/2008

Title: Method and System for Transdermal Drug Delivery

Applicant/Assignee: ACRUX DDS PTY LTD

Application No.: 12/092452   Filing Date: 03/Nov/2006

Abstract:The present invention relates to a method and a system for transdermal delivery of a physiologically active agent. The invention further relates to a method of treatment using the transdermal delivery system and the use of medicaments (5) from manufacture of such as system.

Priority: AU20050906134 Applic. Date: 2005-11-04; WO2006AU01635 Applic. Date: 2006-11-03

Inventor: WOLPERT JOHN [AU]; WILKINS NINA FRANCES [AU]

 

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US PROVISIONAL PATENT APPLICATIONS IN SKIN CARE ACTIVES PUBLISHED IN 2008
This list includes Provisional Patent Applications published in the United States. The list was retrieved by searching the claims section of all patent applications published. Salient search
terms include skin care active ingredients having properties such as anti-ageing, anti-wrinkle, antioxidant, acne control benefits, skin whitening or lightening, blemish removal, etc. This
category includes technology related to the synthesis and delivery of actives such as peptides, exfoliants, α-hydroxy acids, herbals, free radical scavengers, "green" derived molecules and
compounds having unique sensory properties.
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