US Patent Applications in Skin Care Actives and Formulations Published
from 2006 to 2007

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US PATENT APPLICATIONS IN SKIN CARE ACTIVES PUBLISHED FROM 2006 TO 2007



Application No.: US20060002868A1  Published: 05/Jan/2006

Title: Cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/883505   Filing Date: 01/Jul/2004

Abstract:Use of cosmetic compositions comprising an --hydroxyaldehyde self-tanning agent and a water-soluble vitamin B3 compound as a self-tanning composition are provided. The cosmetic compositions are useful for imparting a natural, even and durable tan to the skin when topically applied.

Priority:

Inventor: CROOK TERESA B [GB]; STEPHENS ALISON F [GB]


Application No.: US20060002872A1  Published: 05/Jan/2006

Title: Solubilization of triazine UV-screening agents with arylalkyl benzoate compounds/amide-based oils and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172885   Filing Date: 05/Jul/2005

Abstract:Topcially applicable photoprotective compositions having improved sun protection factor, cosmetic properties and/or stability contain: (a) at least one 1,3,5-triazine UV-screening agent, (b) at least one mixture including: (i) at least one arylalkyl benzoate compound, and (ii) at least one oil containing in its structure at least one amide unit.

Priority: FR20040051421 Applic. Date: 2004-07-02; US20040589007P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]; FIANDINO CECILE [FR]


Application No.: US20060002873A1  Published: 05/Jan/2006

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds/amide-based oils and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172902   Filing Date: 05/Jul/2005

Abstract:Topically applicable, photostable compositions with respect to UV radiation contain at least one dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least one amide-based oil.

Priority: FR20040051417 Applic. Date: 2004-07-02; US20040589010P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]


Application No.: US20060002874A1  Published: 05/Jan/2006

Title: Topical pharmaceutical composition to treat hyperpigmentation of the skin

Applicant/Assignee:

Application No.: 11/150821   Filing Date: 10/Jun/2005

Abstract:Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

Priority: US2000-607892 Applic. Date: 2000-06-30; US2002-178082 Applic. Date: 2002-06-21; US2001-972008 Applic. Date: 2001-10-04; US2000-738410 Applic. Date: 2000-12-14; US2000-569889 Applic. Date: 2000-05-11; US1999-465098 Applic. Date: 1999-12-16; US2000-738395 Applic. Date: 2000-12-14

Inventor: MAIBACH HOWARD I [US]; LUO ERIC C [US]; HSU TSUNG-MIN [US]


Application No.: US20060002882A1  Published: 05/Jan/2006

Title: Rinse-out cosmetic composition comprising elastomeric film-forming polymers, use thereof for conditioning keratin materials

Applicant/Assignee:

Application No.: 11/171315   Filing Date: 01/Jul/2005

Abstract:The present disclosure relates to a cosmetic composition comprising, in a cosmetically acceptable medium, at least one elastomeric film-forming polymer, wherein film obtained by drying the at least one elastomeric film-forming polymer at ambient temperature and at a relative humidity of 55%+-5%, has properties comprising: (a) an elongation at break (epsilonb) of greater than or equal to 800%, (b) an instantaneous recovery (Ri) at least equal to 75%, after an elongation of 150%, and (c) a recovery (R300) at 300 seconds of greater than 80%, the at least one elastomeric film-forming polymer being water-soluble. This composition makes it possible, for example, to condition keratin fibers such as the hair.

Priority: FR20040007305 Applic. Date: 2004-07-01; US20040587853P Applic. Date: 2004-07-15

Inventor: ROLLAT-CORVOL ISABELLE [FR]; GAWTREY JONATHAN [FR]


Application No.: US20060002884A1  Published: 05/Jan/2006

Title: Anti-ageing skin cosmetic

Applicant/Assignee:

Application No.: 10/520562   Filing Date: 07/Jan/2005

Abstract:The invention relates to a cosmetic based on various natural raw materials, which can be used to counter ageing processes of the human skin. The inventive cosmetic contains 0.1-5% by weight of an extract from a mixture of fig leaves and fruits, 0.1-3% by weight of an extract from pomegranate fruits, 0.001-0.5% by weight of a ground dry mixture of rosemary stems and leaves, 0.01-3% by weight of liposomes containing an extract from peeled musk melons, 0.1-5% by weight of liposomes containing a plankton extract containing the photolyase enzyme, 0.1-5% by weight of liposomes containing 0.1 to 0.5% by weight, in relation to the liposome weight, of a micrococcus lysate containing the UV-endonuclease enzyme

and up to 100% by weight, other active substances, carrier substances, adjuvants or mixtures thereof.

Priority: DE20021031468 Applic. Date: 2002-07-08; WO2003DE02157 Applic. Date: 2003-06-23

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Application No.: US20060002910A1  Published: 05/Jan/2006

Title: Agent for the anti-adhesion of skin pathogenic flora

Applicant/Assignee:

Application No.: 11/217930   Filing Date: 01/Sep/2005

Abstract:Bacterial agents for preparing compositions which are for cosmetic, pharmaceutical or veterinary use and which are intended to stabilize and/or regulate the cutaneous ecosystem of mammals. These bacterial agents are extracts of a bacterium, or a bacterium and are selected for their adhesion to skin cells and anti-adhesion to pathogens of the cutaneous system. The invention also relates to compositions containing such agents.

Priority: EP19990204489 Applic. Date: 1999-12-22; US2002-177589 Applic. Date: 2002-06-21; WO2000EP12719 Applic. Date: 2000-12-13

Inventor: BAUR MARKUS [DE]; ZINK RALF [CH]; AUZANNEAU ISABELLE [FR]; BUFFARD KARINE [FR]


Application No.: US20060002944A1  Published: 05/Jan/2006

Title: Treatment of complement-associated disorders

Applicant/Assignee:

Application No.: 11/159919   Filing Date: 22/Jun/2005

Abstract:The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.

Priority: US2004-964263 Applic. Date: 2004-10-12; US1999-380138 Applic. Date: 1999-08-25; WO1999US05028 Applic. Date: 1999-03-08; WO1998US24855 Applic. Date: 1998-11-20; US19980078936P Applic. Date: 1998-03-20; US2004-767374 Applic. Date: 2004-01-29; US2004-767904 Applic. Date: 2004-01-29; US2001-953499 Applic. Date: 2001-09-14; WO2003US31207 Applic. Date: 2003-10-01; US2003-633008 Applic. Date: 2003-07-31; US2002-265542 Applic. Date: 2002-10-03; US1999-254465 Applic. Date: 1999-03-05

Inventor: ASHKENAZI AVI [US]; HELMY KARIM Y [US]; FONG SHERMAN [US]; GODDARD AUDREY [US]; GURNEY AUSTIN L [US]; KATSCHKE KENNETH J JR [US]; LOOKEREN MENNO V [US]; WOOD WILLIAM I [US]


Application No.: US20060002987A1  Published: 05/Jan/2006

Title: Dissolvable film composition

Applicant/Assignee:

Application No.: 11/158153   Filing Date: 21/Jun/2005

Abstract:A system, a kit and methods for delivering an effective amount of a labile active to the skin, comprising a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.

Priority: US20040581842P Applic. Date: 2004-06-22

Inventor: BEVACQUA ANDREW J [US]; LENTINI PETER J [US]; KEELER TRACY N [US]; ZECCHINO JULLES R [US]; VASSILIOU PAULINE [US]


Application No.: US20060003017A1  Published: 05/Jan/2006

Title: Antioxidants in clusters of structured water

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 11/190567   Filing Date: 27/Jul/2005

Abstract:The invention relates to structured water and its antioxidant activity. In addition, the present invention relates to antioxidants incorporated within the cluster structure of either electropositive (S water) or electronegative (I water). The structured water, having the antioxidant within its cluster structure, has a stabilizing effect on the antioxidant. In addition, the antioxidant activity inherent to structured water is enhanced by the presence of the antioxidant within its cluster structure. The present invention also includes methods of removing or reducing free radicals on the skin and thereby preventing the signs of skin aging and the risks of cancer associated with the presence of free radicals in the skin.

Priority: US2002-183819 Applic. Date: 2002-06-27

Inventor: IONITA-MANZATU VASILE [US]; IONITA-MANZATU MIRELA [US]; CIOCA GHEORGHE [US]; BEVACQUA ANDREW J [US]


Application No.: US20060003907A1  Published: 05/Jan/2006

Title: Detergent composition with benefit agents

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/980478   Filing Date: 03/Nov/2004

Abstract:A water-in-oil emulsion system as a storage stable carrier of high pH sensitivity benefit agents or actives comprising i) an aqueous phase including at least one water soluble and/or dispersible benefit agent

ii) a hydrophobic protective carrier phase for the aqueous phase containing the benefit agent

and iii) an emulsifier or a dispersant. Also provided is a rinse off non-liquid cleansing composition comprising the water-in-oil emulsion system and a second phase which is a continuous alkaline phase.

Priority: IN2003MU01166 Applic. Date: 2003-11-06

Inventor: KRISHNAN VENKATESWARAN [IN]; SHAH PANKAJ C [IN]; SIVAKUMAR ANANTHASUBRAMANIAN [IN]


Application No.: US20060003919A1  Published: 05/Jan/2006

Title: Cosmetic/dermatological applications of LIF

Applicant/Assignee:

Application No.: 11/137344   Filing Date: 26/May/2005

Abstract:Leukemia inhibitory factor ("LIF"), an LIF analogue, an LIF mimetic, a product capable of stimulating the expression of endogenous LIF and mixtures thereof are useful for maintaining and/or stimulating the regenerative power of a population of human undifferentiated skin stem cells and/or epidermal progenitors, and are also useful for treating dry and/or chapped and/or aged skin and/or hair loss, as well as for treating skin burns and promoting skin regeneration and/or cicatrization.

Priority: FR20040051034 Applic. Date: 2004-05-26; US20050641434P Applic. Date: 2005-01-06

Inventor: FORTUNEL NICOLAS [FR]; BERNARD DOMINIQUE [FR]; FERRARIS CORINNE [FR]; REGNIER MARCELLE [FR]


Application No.: US20060003969A1  Published: 05/Jan/2006

Title: Compositions and methods for treating pathological infections

Applicant/Assignee:

Application No.: 11/172285   Filing Date: 30/Jun/2005

Abstract:The present invention relates to compositions and methods for treating pathological infections. An embodiment of the present invention is directed to a topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment which includes a pharmaceutically effective amount of an anti-yeast, anti-fungal or antibacterial pharmaceutically active agent

and a pharmaceutically acceptable carrier.

Priority: US20040589215P Applic. Date: 2004-07-02; US20040590813P Applic. Date: 2004-07-23

Inventor: MANANDHAR MADHUSUDAN P [US]


Application No.: US20060004071A1  Published: 05/Jan/2006

Title: Triple anti-irritant composition

Applicant/Assignee: MEDICIS PHARMACEUTICAL CORPORATION

Application No.: 10/884146   Filing Date: 02/Jul/2004

Abstract:The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.

Priority:

Inventor: BHATIA KULJIT S [US]; PATEL BHIKU G [US]; GANS EUGENE H [US]


Application No.: US20060005325A1  Published: 12/Jan/2006

Title: Leave-in cosmetic composition comprising at least one elastomeric film-forming polymer and use thereof for conditioning keratin materials

Applicant/Assignee:

Application No.: 11/171211   Filing Date: 01/Jul/2005

Abstract:Disclosed is a leave-in cosmetic composition comprising, in a cosmetically acceptable medium, at least one elastomeric film-forming polymer chosen such that the film obtained by drying this polymer, in an aqueous or alcoholic medium, at ambient temperature and at a relative humidity of 55%, has a mechanical profile comprising: (a) an elongation at break (epsilonb) of greater than or equal to 800%, (b) an instantaneous recovery (Ri) at least equal to 75%, after an elongation of 150%, and (c) a recovery (R300) at 300 seconds of greater than 80%.

Priority: FR20040007304 Applic. Date: 2004-07-01; US20040587856P Applic. Date: 2004-07-15

Inventor: SAMAIN HENRI [FR]; ROLLAT-CORVOL ISABELLE [FR]; GAWTREY JONATHAN [FR]


Application No.: US20060008426A1  Published: 12/Jan/2006

Title: Cosmetic and dermatological photoprotective formulations

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/087395   Filing Date: 23/Mar/2005

Abstract:Cosmetic or dermatological preparations which have a UVA balance of more than 15, and use thereof.

Priority: DE200410014614 Applic. Date: 2004-03-23; DE200410020627 Applic. Date: 2004-04-27

Inventor: DORING THOMAS [DE]; SUGAR MARTIN [DE]; WOLBER RAINER [DE]; WENDEL VOLKER [DE]; BLATT THOMAS [DE]; MUNDT CLAUDIA [DE]; SCHULZ JENS [DE]; BATZER JAN [DE]; DIPPE RIXA [DE]


Application No.: US20060008428A1  Published: 12/Jan/2006

Title: Method of promoting the penetration of a cosmetic active and composition therefore

Applicant/Assignee: L'OREAL

Application No.: 11/153380   Filing Date: 16/Jun/2005

Abstract:The invention relates to a method of promoting the penetration of a cosmetic active, wherein a composition in the form of a water-in-oil emulsion is applied topically, said emulsion comprising a fatty phase with a polarity ba greater than or equal to 0.1 and comprising a mixture of at least two oils, and in that the application of said emulsion is made simultaneously, with an interval or sequentially in time with the application of the cosmetic active.

Priority: FR20040006539 Applic. Date: 2004-06-16; US20040621804P Applic. Date: 2004-10-26

Inventor: SEYLER NATHALIE [FR]; GUIRAMAND CAROLE [FR]; RIBAUD CHRISTELE [FR]


Application No.: US20060008429A1  Published: 12/Jan/2006

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate/bis-resorcinyl triazine compounds and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172932   Filing Date: 05/Jul/2005

Abstract:Topically applicable, photostable compositions with respect to UV radiation contain at least one dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least one bis-resorcinyl triazine compound.

Priority: FR20040051419 Applic. Date: 2004-07-02; US20040589009P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]


Application No.: US20060008430A1  Published: 12/Jan/2006

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds and photoprotective cosmetic compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172949   Filing Date: 05/Jul/2005

Abstract:Topically applicable cosmetic/dermatological photoprotective compositions contain at least one dibenzoylmethane UV-screening agent, and, as a photostabilizer therefor, at least one arylalkyl benzoate compound of formula (I) or (II) below: with the proviso that: (i) the subject compositions are characteristically devoid of any octyl methoxycinnamate

and (ii) same are other than a solution of butyl methoxydibenzoylmethane in 2-phenylethyl benzoate, 2-phenylethyl o-toluate, 2-phenylethyl p-toluate or in a 2-phenylethyl o-toluate/2-phenylethyl p-toluate (1/1) mixture.

Priority: FR20040051416 Applic. Date: 2004-07-02; US20040588984P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]


Application No.: US20060008436A1  Published: 12/Jan/2006

Title: Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/671508   Filing Date: 29/Sep/2003

Abstract:Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in which Hy is a heterocycle of 4 to 7 atoms, optionally comprising carbonyl/thiocarbonyl functional groups, and G is O, S or NH.

Priority: FR20020012018 Applic. Date: 2002-09-27; US20020415462P Applic. Date: 2002-10-03

Inventor: BOULLE CHRISTOPHE [FR]; ROZOT ROGER [FR]; DALKO MARIA [FR]


Application No.: US20060008437A1  Published: 12/Jan/2006

Title: Hair and skin care composition

Applicant/Assignee:

Application No.: 10/885166   Filing Date: 06/Jul/2004

Abstract:The present invention provides cosmetic compositions that form a durable film or coating on surfaces such as hair or skin. The compositions of the invention comprise one or more anionic silicones and one or more high molecular weight esters, the combination of which provides a durable film. Methods for treatment of hair and skin employing the compositions of the invention are also provided.

Priority:

Inventor: ROBINSON FREDA E [US]; BUCKRIDGE KENNETH [US]; FLEISSMAN LEONA G [US]


Application No.: US20060008438A1  Published: 12/Jan/2006

Title: Multi-phased personal care composition

Applicant/Assignee:

Application No.: 11/178047   Filing Date: 08/Jul/2005

Abstract:The present invention is a multi-phased personal care composition that contains at least two visually distinct phases. At least one of the visually distinct phases is a benefit phase that has a Flow Onset Temperature of at least about 97 DEG F.

and wherein said visually distinct phases form a pattern

and wherein said visually distinct phases are packaged in physical contact with one another and are stable.

Priority: US20040586740P Applic. Date: 2004-07-09

Inventor: VELARDE ANDRES E [US]; HEDGES STEVEN K [US]; SMITH EDWARD D III [US]; WEI KARL S [US]


Application No.: US20060008487A1  Published: 12/Jan/2006

Title: Method of skin care and/or treatment using thioredoxin

Applicant/Assignee:

Application No.: 11/179170   Filing Date: 12/Jul/2005

Abstract:Methods for the prevention and treatment of skin damage arising from the exposure to UV radiation and other stressors capable of leading to the formation of free radicals, using the small dithiol protein thioredoxin in a dermatologically acceptable carrier that can be applied topically are disclosed. Some embodiments may include other proteins such as superoxide dismutase and/or catalase, as well as other antioxidant molecules such as reduced glutathione, vitamin E, vitamin C, lycopene, astaxanthin and/or tocotrienols.

Priority: US20040587217P Applic. Date: 2004-07-12

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]


Application No.: US20060009398A1  Published: 12/Jan/2006

Title: Compositions comprising gelatin-glycine and carotenoids

Applicant/Assignee: MAVI SUD S.R.L

Application No.: 11/177500   Filing Date: 11/Jul/2005

Abstract:The invention relates to cosmetic and pharmaceutical agents and compositions useful in the treatment of those phenomena and manifestations generally causing or accompanying the aging of skin, ocular tissues and other tissues. In particular the invention relates to the use of different mixture of carotenoids, preferably lutein, and gelatin-glycine for improving hydration, elasticity and lipid content of the skin and for protecting skin and ocular tissues from hazardous radiations.

Priority: EP20040103266 Applic. Date: 2004-07-09

Inventor: MORGANTI PIERFRANCESCO [IT]; ROBERTS RICHARD L [US]


Application No.: US20060009494A1  Published: 12/Jan/2006

Title: Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes

Applicant/Assignee:

Application No.: 11/168017   Filing Date: 27/Jun/2005

Abstract:Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administering, topically or systemically, at least one of (i) an inhibitor of the matrix degrading enzymes and (ii) a cytokine inhibitor that alleviates inflammation and thus also alleviate neutrophil infiltration. Alleviating the matrix degradation and renormalizing procollagen biosynthesis allows for reduced inflammation and better natural repair of acne-affected skin. Inhibiting cytokines alleviates induction of MMPs in resident skin cells, and also alleviates inflammation with its concommitant induction of neutrophils from the blood stream bringing MMPs and elastase into the acne lesion. Dimishing the presence of matrix-degrading enzymes in the acne lesion reduces imperfect repair of the skin and thus decreases scarring in acne-affected skin.

Priority: US2001-852154 Applic. Date: 2001-05-09; US2000-576597 Applic. Date: 2000-05-22; US19990134984P Applic. Date: 1999-05-20

Inventor: VOORHEES JOHN J [US]; KANG SEWON [US]; FISHER GARY J [US]


Application No.: US20060010004A1  Published: 12/Jan/2006

Title: Method for providing customized products

Applicant/Assignee:

Application No.: 11/176138   Filing Date: 07/Jul/2005

Abstract:In a first aspect a method for producing a customized product is disclosed. The method includes providing a high internal phase emulsion, providing at least one other component of a customized product, generating a customized product formula based at least in part on consumer data and mixing the emulsion with the at least one other component in accordance with the customized product formula to produce the customized product. In a second aspect, a method of manufacturing a customized personal product using an oil-in-water high internal phase emulsion is disclosed.

Priority: US20040586603P Applic. Date: 2004-07-09

Inventor: DECKNER GEORGE E [US]


Application No.: US20060013769A1  Published: 19/Jan/2006

Title: Transdermal drug delivery formulations and method of determining optimal amounts of vasodilators therein

Applicant/Assignee:

Application No.: 10/893733   Filing Date: 16/Jul/2004

Abstract:A method for determining and demonstrating the role of vasodilator chemical agents in the development and practice of transdermal drug delivery systems. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.

Priority:

Inventor: CARTER STEPHEN [US]; ZHU ZHEN [US]; PATEL KANU [US]


Application No.: US20060013782A1  Published: 19/Jan/2006

Title: Use of active extracts to improve the appearance of skin, lips, hair and/or nails

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/155359   Filing Date: 17/Jun/2005

Abstract:There is provided a composition having at least one of the following active extracts Butea frondosa, Naringi crenulata, Stenoloma chusana, or any combinations thereof. There is also provided a composition having at least one of the following additional extracts Azadirachta indica, Glycyrrhiza glabra linn., Morinda citrifolia, tomato glycolipid or any combinations thereof in combination with one or more of the active extracts. The compositions and methods of the invention are effective to improve the aesthetic appearance of skin, lips, hair and/or nails, especially by lightening the skin, lips, hair and/or nails.

Priority: WO2003US39893 Applic. Date: 2003-12-16; US2002-321706 Applic. Date: 2002-12-17

Inventor: MAHALINGAM HARISH [US]; JONES BRIAN C [US]; MCCAIN NICOLE [US]; LIMTRAKUL PORNNGARM [TH]


Application No.: US20060013788A1  Published: 19/Jan/2006

Title: Cosmetic composition for caring for or making up keratin materials, comprising at least one polyester, and method of use thereof

Applicant/Assignee:

Application No.: 11/179463   Filing Date: 13/Jul/2005

Abstract:The present disclosure relates to a cosmetic composition, for caring for or making up keratin materials, comprising, in a cosmetically acceptable medium, i) at least one polyester derived from the esterification, with a polycarboxylic acid, of an aliphatic hydroxycarboxylic acid ester comprising at least two hydroxyl groups and ii) at least one volatile oil. The present disclosure also relates to a method of imparting to a cosmetic composition at least one cosmetic property chosen from gloss, staying-power and comfort properties.

Priority: FR20040051514 Applic. Date: 2004-07-13; US20040591625P Applic. Date: 2004-07-28

Inventor: FILIPPI VANINA [FR]


Application No.: US20060013792A1  Published: 19/Jan/2006

Title: Solid water-in-oil cosmetic emulsion

Applicant/Assignee:

Application No.: 11/182801   Filing Date: 18/Jul/2005

Abstract:Disclosed is a solid water-in-oil emulsion comprising an aqueous phase emulsified with at least one emulsifying surfactant in a fatty phase comprising at least one ester oil and at least one wax, wherein the at least one ester oil is present in an amount greater than the at least one wax and wherein the emulsion has, after at least one month at 37 DEG C., a hardness wherein the penetration force is greater than or equal to 45 g. Also disclosed is a non-therapeutic cosmetic process for making up or caring for the skin, comprising the application to the skin of a composition comprising said emulsion.

Priority: FR20040051549 Applic. Date: 2004-07-16; US20040601989P Applic. Date: 2004-08-17

Inventor: FONTAINE JACQUELINE [FR]; THEMENS AGNES [FR]


Application No.: US20060013793A1  Published: 19/Jan/2006

Title: Solid water-in-oil cosmetic emulsion

Applicant/Assignee:

Application No.: 11/182849   Filing Date: 18/Jul/2005

Abstract:Disclosed herein is a solid water-in-oil emulsion comprising an aqueous phase emulsified in a fatty phase comprising at least one ester oil and at least one wax, and at least one silicone surfactant comprising at least one polyhydroxylated chain or at least one alkyl dimethicone copolyol chosen from C8-C22 alkyl dimethicone copolyols, as well as a process for making up or caring for skin, comprising applying to the skin the emulsion.

Priority: FR20040051548 Applic. Date: 2004-07-16; FR20040051550 Applic. Date: 2004-07-16; US20040601990P Applic. Date: 2004-08-17; US20040602328P Applic. Date: 2004-08-18

Inventor: THEMENS AGNES [FR]


Application No.: US20060013794A1  Published: 19/Jan/2006

Title: Cosmetic or pharmaceutical composition comprising peptides with the sequences arggly-ser

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 10/534355   Filing Date: 09/May/2005

Abstract:The invention relates to the use of at least one peptide, with the sequence (AA)n-Arg-Gly-Ser-(AA)n, where (AA) is any amino acid or a derivative thereof and n=0 to 3, as an active ingredient in or for the preparation of a cosmetic and/or dermatological and/or pharmaceutical preparation. The invention also relates to the use thereof for the treatment, amongst others, of the effects of cutaneous aging and/or the use thereof against cellulite, to a composition comprising the same and to a cosmetic method for the treatment of the skin using said peptide or said composition.

Priority: FR20020014012 Applic. Date: 2002-11-08; FR20030009889 Applic. Date: 2003-08-13; WO2003FR03280 Applic. Date: 2003-11-04

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; BOTTO JEAN-MARIE [FR]


Application No.: US20060013866A1  Published: 19/Jan/2006

Title: Transdermal drug delivery formulations with optimal amounts of vasodilators therein

Applicant/Assignee:

Application No.: 10/893778   Filing Date: 16/Jul/2004

Abstract:Topical drug delivery formulations with optical amounts of vasodilator. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.

Priority:

Inventor: CARTER STEPHEN G [US]; ZHU ZHEN [US]; PATEL KANU [US]


Application No.: US20060014158A1  Published: 19/Jan/2006

Title: Use of a fibroblast growth factor-binding protein for the treatment and diagnosis of diabetic wound healing problems

Applicant/Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V

Application No.: 10/927322   Filing Date: 26/Aug/2004

Abstract:The present invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides, and functional variants of these polypeptides, respectively, or of nucleic acids encoding these polypeptides or variants, or of functional variants of these nucleic acids, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for treating, diagnosing and/or preventing wound healing disturbances which are characterized by a reduced quantity of FGF-BP, in particular diabetes-associated wounds, and also to the use of at least one FGF-BP polypeptide as depicted in SEQ ID No. 1 and SEQ ID No. 3 and/or of at least one FGF-BP-encoding nucleic acid as depicted in SEQ ID No. 2 and SEQ ID No. 4 and/or of antibodies or antibody fragments which are directed against an FGF-BP polypeptide which can be used in accordance with the invention, or functional variants thereof, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for identifying pharmacologically active substances which increase the activity of expression of FGF-BP.

Priority: EP20020004299 Applic. Date: 2002-02-28; WO2003EP02122 Applic. Date: 2003-02-28; US20020362497P Applic. Date: 2002-03-06

Inventor: GOPPELT ANDREAS [AT]; BITTNER MICHAELA [AT]


Application No.: US20060014240A1  Published: 19/Jan/2006

Title: Extraction and purification method of active constituents from stem of lonicera japonica thunb., its usage for anti-inflammatory and analgesic drug

Applicant/Assignee: SK CHEMICALS CO., LTD

Application No.: 10/527139   Filing Date: 08/Mar/2005

Abstract:Disclosed is a method for extracting and purifying active constituents from honeysuckle (Lonicera japonica Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

Priority: KR20020055106 Applic. Date: 2002-09-11; KR20020058494 Applic. Date: 2002-09-26; WO2003KR01851 Applic. Date: 2003-09-08

Inventor: KWAK WIE-JONG [KR]; CHO YONG-BAIK [KR]; HAN CHANG-KYUN [KR]; SHIN HEE J [KR]; RYU KEUN H [KR]; YOO HUNSEUNG [KR]; RHEE HAI I [KR]


Application No.: US20060014282A1  Published: 19/Jan/2006

Title: Cell and tissue engineering utilizing LIF

Applicant/Assignee: L'OREAL

Application No.: 11/137402   Filing Date: 26/May/2005

Abstract:Leukemia Inhibitory Factor ("LIF"), an LIF analogue, an LIF mimetic and a product capable of stimulating the expression of endogenous LIF, and mixtures thereof are useful, for (i) promoting the multiplication, in vitro, of a population of human skin stem cells and/or epidermal progenitors while maintaining them in an undifferentiated state, and/or for (ii) maintaining and/or increasing their capacity to generate a pluristratified epithelium, in particular a pluristratified epidermis and/or all or some of the skin appendages

also a library or a culture of human undifferentiated skin stem cells and/or epidermal progenitors is obtained in the presence of LIF, as are reconstructed epidermides and/or reconstructed skin, and kits for producing libraries of cells or reconstructed epidermides, and stem cells or reconstructed epidermides are prepared for the treatment of individuals exhibiting damaged skin (individuals suffering from third degree burns and individuals suffering from genetic diseases affecting the skin).

Priority: FR20040051037 Applic. Date: 2004-05-26; US20050641435P Applic. Date: 2005-01-06

Inventor: FORTUNEL NICOLAS [FR]; BERNARD DOMINIQUE [FR]; FERRARIS CORINNE [FR]; REGNIER MARCELLE [FR]


Application No.: US20060014832A1  Published: 19/Jan/2006

Title: Highly pure bases of 3,3-dipheyl propylamine monoesters

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/532836   Filing Date: 26/Apr/2005

Abstract:The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterised in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments.

Priority: DE20031015917 Applic. Date: 2003-04-08; WO2004EP03567 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]


Application No.: US20060018848A1  Published: 26/Jan/2006

Title: Photoprotective compositions comprising methyltrialkylsilanes containing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function

Applicant/Assignee: L'OREAL

Application No.: 11/189975   Filing Date: 27/Jul/2005

Abstract:Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active in the field of UV radiation.

Priority: FR20030000909 Applic. Date: 2003-01-28; WO2003EP15038 Applic. Date: 2003-12-19; US20030450708P Applic. Date: 2003-03-03

Inventor: RICHARD HERVE [FR]


Application No.: US20060018849A1  Published: 26/Jan/2006

Title: Cosmetic or dermatological preparations of the oil-in-water type

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/191230   Filing Date: 27/Jul/2005

Abstract:The present invention includes cosmetic or dermatological preparations of the oil-in-water type comprising an oil phase having incorporated therein one or more citric esters of the general structural formula in which R<1>, R<2 >and R<3>, independently of one another, are chosen from the group consisting of ethyl, propyl and butyl, and R<4 >is a hydrogen atom or a CH3(CO) group

and a water phase, where the difference in density between the oil phase and the water phase (determinable using a computerized digital density meter of the type DMA 45 from chempro/PA at 25 DEG C.) is not greater than 0.01 g.cm<-3>. The present invention also includes a method for the stabilization of oil-in-water formulations.

Priority: DE20001000210 Applic. Date: 2000-01-05; US2002-190075 Applic. Date: 2002-07-03; WO2000EP12780 Applic. Date: 2000-12-15

Inventor: MULLER ANJA [DE]


Application No.: US20060018868A1  Published: 26/Jan/2006

Title: Use of a cotton honeydew extract as active ingredient in or for preparing a cosmetic and/or pharmaceutical composition

Applicant/Assignee: SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS S.A

Application No.: 10/537359   Filing Date: 03/Jun/2005

Abstract:The invention concerns the use, as active principle, in or for preparing a composition, of an efficient amount of at least one extract of cotton honeydew, the extract or the composition being designed for care of keratinous substrates. The invention also concerns a cosmetic and/or pharmaceutical composition containing said extract, and a method for cosmetic treatment of the skin using said cotton honeydew extract or the composition containing same.

Priority: FR20020015189 Applic. Date: 2002-12-03; WO2003FR03557 Applic. Date: 2003-12-02

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; PEYRONEL DOMINIQUE [FR]


Application No.: US20060018933A1  Published: 26/Jan/2006

Title: Novel drug delivery system

Applicant/Assignee:

Application No.: 11/134631   Filing Date: 19/May/2005

Abstract:A novel modified release dosage form comprising of a high solubility active ingredient, which utilizes dual retard technique to effectively reduce the quantity of release controlling agents. Present invention can optionally comprise additionally another active ingredient as an immediate release form or modified release form. Present invention also relates to a process for preparing the said formulation.

Priority: IN2002MU00698 Applic. Date: 2002-08-05; IN2002MU00696 Applic. Date: 2002-08-05; IN2003MU00081 Applic. Date: 2003-01-22; US2003-630348 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; NADKARNI SUNIL S [IN]; GUPTA VINOD K [IN]


Application No.: US20060018934A1  Published: 26/Jan/2006

Title: Novel drug delivery system

Applicant/Assignee:

Application No.: 11/134632   Filing Date: 19/May/2005

Abstract:A novel modified release dosage form comprising of a high solubility active ingredient, which utilizes dual retard technique to effectively reduce the quantity of release controlling agents. Present invention can optionally comprise additionally another active ingredient as an immediate release form or modified release form. Present invention also relates to a process for preparing the said formulation.

Priority: IN2002MU00698 Applic. Date: 2002-08-05; IN2002MU00696 Applic. Date: 2002-08-05; IN2003MU00081 Applic. Date: 2003-01-22; US2003-630348 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; NADKARNI SUNIL S [IN]; GUPTA VINOD K [IN]


Application No.: US20060018937A1  Published: 26/Jan/2006

Title: Steroid kit and foamable composition and uses thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/114410   Filing Date: 26/Apr/2005

Abstract:A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a steroid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product

and an outlet capable of releasing the pressurized product as a foam

wherein the pressurized product comprises a foamable composition including: i. a steroid

ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight

iii. a surface-active agent

iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent

v. water

and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid

and mixtures thereof.

Priority: WO2003IB05527 Applic. Date: 2003-10-24; IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29

Inventor: FRIEDMAN DORON [IL]; BESONOV ALEX [IL]; TAMARKIN DOV [IL]; EINI MEIR [IL]


Application No.: US20060020007A1  Published: 26/Jan/2006

Title: Compositions containing policosanol and biotin and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/898889   Filing Date: 26/Jul/2004

Abstract:A composition is provided which contains policosanol and biotin and which may be used for treating, preventing and or reducing metabolic syndrome, hypercholesterolemia and hypoglycemia related diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, obesity, insulin resistance, dyslipidemia, raised blood pressure, fatigue, premenstrual syndrome, anxiety, depression and/or neurodegenerative disorders, and/or raising HDL cholesterol in humans and animals. The method comprises administering policosanol and biotin which together effectively lower blood glucose levels and lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to biotin.

Priority:

Inventor: BERLIN ROGER [US]


Application No.: US20060020031A1  Published: 26/Jan/2006

Title: Compositions containing policosanol and omega-3 fatty acids and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/898897   Filing Date: 26/Jul/2004

Abstract:A composition is provided which contains policosanol and omega-3 fatty acids and which may be used for treating and or reducing hypercholesterolemic diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), sudden cardiac death, ventricular fibrillation, tachycardia, hypertension, inflammation, thrombosis, deep-vein thrombosis, stroke, macular degeneration, autoimmune and/or immunoregulatory diseases, cardiovascular diseases, anxiety, depression and/or neurodegenerative disorders, and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and omega-3 fatty acids which together effectively lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to omega-3 fatty acids.

Priority:

Inventor: BERLIN ROGER [US]


Application No.: US20060020046A1  Published: 26/Jan/2006

Title: Compositions comprising lycopene for the treatment and prevention of angiogenesis associated pathologies

Applicant/Assignee: DMS IP ASSETS B.V

Application No.: 10/504829   Filing Date: 16/Aug/2004

Abstract:The invention is concerned with the use of lycopene, optionally in combination with vitamin E and/or C or other biologically active ingredients as disclosed in the specification, in the manufacture of a composition for the primary and secondary prevention of angiogenesis-associated pathologies and coadjuvant treatment thereof

as well as with particular novel formulations comprising lycopene.

Priority: EP20020003544 Applic. Date: 2002-02-15; WO2003EP01149 Applic. Date: 2003-02-06

Inventor: GORALCZYK REGINA [CH]; JUNG KLAUS [DE]; LEIN MICHAEL [DE]; BARELLA LUCA [CH]; SILER ULRICH [CH]; STOCKLIN ELISABETH [CH]; WERTZ KARIN [DE]


Application No.: US20060022177A1  Published: 02/Feb/2006

Title: Nanoparticulate organc uv absorber

Applicant/Assignee:

Application No.: 10/509636   Filing Date: 29/Sep/2004

Abstract:The present invention relates to a UV absorber which comprises a finely divided polymer with a volume-average particle size of from 5 to 1 000 nm, to a process for its preparation, and to its use for stabilizing molding compositions and coating films and as a light protection factor in cosmetic formulations.

Priority: DE20021015752 Applic. Date: 2002-04-10; WO2003EP03692 Applic. Date: 2003-04-09

Inventor: KOENEMANN MARTIN [US]


Application No.: US20060024243A1  Published: 02/Feb/2006

Title: Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Applicant/Assignee: AGIS INDUSTRIES (1983) LTD

Application No.: 11/194518   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical foamable composition for topical application of nitroimidazoles such as Metronidazole and a process of manufacturing the same is disclosed. A method of treatment of skin and scalp disorders, especially of rosacea, acne and foul smelling lesions, by dispensing nitroimidazoles such as Metronidazole in foamable composition is also disclosed.

Priority: US20040592524P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; UZAN RINA [IL]; BRAGHINSKI BELA [IL]


Application No.: US20060024251A1  Published: 02/Feb/2006

Title: Water-in-oil emulsion foundation comprising a polyol

Applicant/Assignee:

Application No.: 10/784909   Filing Date: 24/Feb/2004

Abstract:The invention relates to a fluid foundation in the form of water-in-oil emulsion comprising an oil and an aqueous phase comprising a polyol, and optionally polymethyl methacrylate particles, the water+polyol/oil weight ratio being greater than or equal to 0.8. The foundation slides well on the skin and has a sensation of lightness when applied.

Priority: FR20030006150 Applic. Date: 2003-05-22; US20030506774P Applic. Date: 2003-09-30

Inventor: GARDEL NADIA [FR]; BARROIS VERONIQUE [FR]; CHAMPENOIS SANDRINE [FR]


Application No.: US20060024365A1  Published: 02/Feb/2006

Title: Novel dosage form

Applicant/Assignee:

Application No.: 11/134633   Filing Date: 19/May/2005

Abstract:A dosage form comprising of a high dose, high solubility active ingredient as modified release and a low dose active ingredient as immediate release where the weight ratio of immediate release active ingredient and modified release active ingredient is from 1:10 to 1:15000 and the weight of modified release active ingredient per unit is from 500 mg to 1500 mg

a process for preparing the dosage form.

Priority: IN2002MU00699 Applic. Date: 2002-08-05; IN2002MU00697 Applic. Date: 2002-08-05; IN2003MU00080 Applic. Date: 2003-01-22; IN2003MU00082 Applic. Date: 2003-01-22; US2003-630446 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; SADANAND SUNIL [IN]; GUPTA VINOD K [IN]


Application No.: US20060024383A1  Published: 02/Feb/2006

Title: Compositions containing policosanol and chromium and/or chromium salts and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/900049   Filing Date: 27/Jul/2004

Abstract:A composition is provided which contains policosanol and chromium and/or chromium salts and which may be used for treating, preventing and or reducing metabolic syndrome, hypercholesterolemia and hypoglycemia related diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, obesity, insulin resistance, dyslipidemia, raised blood pressure, fatigue, premenstrual syndrome, anxiety, depression and/or neurodegenerative disorders, and/or raising HDL cholesterol and/or lean body mass in humans and animals. The method comprises administering policosanol and chromium and/or chromium salts which together effectively lower blood glucose levels and lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to chromium and/or chromium salts.

Priority:

Inventor: BERLIN ROGER [US]


Application No.: US20060025457A1  Published: 02/Feb/2006

Title: Isoindoline compounds and methods of their use

Applicant/Assignee: CELGENE CORPORATION

Application No.: 10/900332   Filing Date: 28/Jul/2004

Abstract:Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclosed.

Priority:

Inventor: MULLER GEORGE W [US]; MAN HON-WAH [US]


Application No.: US20060025486A1  Published: 02/Feb/2006

Title: Compositions containing policosanol and B vitamins and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/900040   Filing Date: 27/Jul/2004

Abstract:A composition is provided which contains policosanol and B vitamins and which may be used for treating and or reducing hypercholesterolemia and hyperhomocysteinemia diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, Lp(a), triglycerides, homocysteine, coronary heart disease (heart attacks and strokes), carotid artery disease, inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, anxiety, depression, neurodegenerative disorders (such as but not limited to Alzheimers), and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and B vitamins which together effectively lower the risk of heart disease. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to B vitamins.

Priority:

Inventor: BERLIN ROGER [US]


Application No.: US20060028545A1  Published: 09/Feb/2006

Title: Vision thermalization for sightless & visually impaired

Applicant/Assignee:

Application No.: 10/914257   Filing Date: 09/Aug/2004

Abstract:A Vision Thermalization, "VT" light-to-heat transducer, versatile video transformation system, via Biophysics Resonance of forehead cells with thin film transistors infrared "display" (1kx0.0015Cx640x480 VGA) and alternative image processing methodology thereof to convert, for the sightless and visually impaired, light waves, or TV received signals or 2D/3D video camera signals into infrared patterns of sensible heat waves such as produced by the product of voltage and current in an active matrix of thin film transistors (AM-TFT), typically used with liquid crystal displays, in order to exploit the viper-like thermal vision sensibility of 10 parts/million (0.003C/305K) and biophysics resonance of thermo regulating amino acids.

Priority:

Inventor: STAPLETON JOHN J [US]


Application No.: US20060029556A1  Published: 09/Feb/2006

Title: Aqueous-alcoholic depigmenting gels

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/150176   Filing Date: 13/Jun/2005

Abstract:Topically applicable, stable and non-irritating aqueous-alcoholic cosmetic/dermatological gels suited for cutaneous depigmentation contain water, at least one alcohol, at least one gelling agent, at least one phenolic compound, at least one retinoid, and, optionally, at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

Priority: FR20020015750 Applic. Date: 2002-12-12; WO2003EP15021 Applic. Date: 2003-12-03; US20020434433P Applic. Date: 2002-12-19

Inventor: LOUIS FABIENNE [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]


Application No.: US20060029563A1  Published: 09/Feb/2006

Title: Cutanceous metabolic bio-activator

Applicant/Assignee: JEAN-NOEL THOREL

Application No.: 10/537816   Filing Date: 07/Jun/2005

Abstract:The invention relates to a cosmetic composition comprising a bio-active system which combines (i) a stable form in aqueous solution of ATP (adenosine-tri-phosphate) with optionally an ATP precursor, e.g. Gp4G (diguanosine tetraphosphate), or Ap4A (diadenosine tetraphosphate), and (ii) at least one biomimetic peptide comprising at most six amino acids, mimicking a cutaneous polypeptide or a cutaneous protein, or a biomolecule which is agonist or antagonist in relation to the aforementioned polypeptide or protein. According to the invention, the composition takes the form of a water-in-oil or oil-in-water emulsion, the bio-active system being included in the aqueous phase.

Priority: FR20020016871 Applic. Date: 2002-12-30; FR20020016872 Applic. Date: 2002-12-30; FR20020016873 Applic. Date: 2002-12-30; FR20020016874 Applic. Date: 2002-12-30; WO2003FR03883 Applic. Date: 2003-12-23

Inventor: THOREL JEAN-NOEL [FR]; REDZINIAK GERARD [FR]


Application No.: US20060029623A1  Published: 09/Feb/2006

Title: Invert emulsions comprising at least one active agent sensitive to water and cosmetic/dermatological applications thereof

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/196301   Filing Date: 04/Aug/2005

Abstract:Cosmetic/dermatological compositions useful for the treatment of a variety of dermatological conditions, including keratinization disorders, acne, eczema, psoriasis, etc., comprise an invert emulsion containing at least one active agent sensitive to the presence of water, notably a derivative of vitamin D, and solubilized in a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7

these invert emulsions exhibit good stability and avoid crystallization of the active agent and/or chemical degradation thereof.

Priority: FR20030001349 Applic. Date: 2003-02-05; WO2004EP04526 Applic. Date: 2004-02-03; US20030452940P Applic. Date: 2003-03-10

Inventor: ASTRUC FANNY [FR]; ORSONI SANDRINE [FR]; BRZOKEWICZ ALAIN [FR]


Application No.: US20060029624A1  Published: 09/Feb/2006

Title: Low-residue deodorant or antiperspirant stick based on an oil-in-water dispersion

Applicant/Assignee:

Application No.: 11/192389   Filing Date: 28/Jul/2005

Abstract:Deodorant or antiperspirant sticks based on an oil-in-water dispersion for application to the skin.

Priority: DE200410036689 Applic. Date: 2004-07-28

Inventor: BANOWSKI BERNHARD [DE]; WADLE ARMIN [DE]; CLASS MARCUS [DE]


Application No.: US20060029654A1  Published: 09/Feb/2006

Title: Analgesic patch for sports injury rehabilitation medicine and method to alleviate pain

Applicant/Assignee:

Application No.: 11/196964   Filing Date: 04/Aug/2005

Abstract:The present invention relates to a method for topical treatment of pain resulting from a sports injury, including injuries to bones and soft tissue, such as ligaments, muscles or tendons. The method includes the steps of: applying to skin of a subject suffering from pain resulting from a sports injury a transdermal drug delivery system comprising a formulation comprising a pain-relieving amount of a local anesthetic and a pharmaceutically acceptable carrier, wherein the transdermal drug delivery system is applied to a skin site proximate to or in the region of a sports injury, and relieving the pain. The concentrated local anesthetic in the patch penetrates deeply below the skin to the injury site to inhibit pain receptors throughout the damaged body tissue.

Priority: US20040598694P Applic. Date: 2004-08-04

Inventor: CASSEL R D [US]


Application No.: US20060029657A1  Published: 09/Feb/2006

Title: Topical skin protectant compositions

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 11/089030   Filing Date: 25/Mar/2005

Abstract:Skin protectant compositions that are free of cholesterol and suitable for topical application to skin of a mammal. In a preferred embodiment, these skin protectant compositions comprise a ceramide

a squalane

a phytosterol-containing liposome

a phospholipid-containing ingredient

at least one triglyceride

and at least one dermatologically acceptable excipient. These compositions are capable of restoring or repairing a skin lipid barrier of a mammal, and treating skin conditions associated therewith.

Priority: US20040556428P Applic. Date: 2004-03-26

Inventor: POPP KARL F [US]; WAGNER JOHN A [US]


Application No.: US20060029673A1  Published: 09/Feb/2006

Title: Transdermal administration of (r)-3,3-diphenylpropylamin-monoesters

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/533683   Filing Date: 26/Apr/2005

Abstract:The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3 alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.

Priority: DE20031015878 Applic. Date: 2003-04-08; WO2004EP03574 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]


Application No.: US20060029683A1  Published: 09/Feb/2006

Title: Appendix of 2.7% (approx.) 9% saline, 56% saline

Applicant/Assignee:

Application No.: 11/017708   Filing Date: 05/Sep/2005

Abstract:The name of invention is Saline and the Saline is NaCl sol. is distinguished by density. In this invention solution, Pus at wound can be removed without curettage and antibiotics by lysis of phosphatide of H+. In 2.7% (approx.) 9% Saline sol. of in potential power of semipermeable memb., Membrane formation and cell mutiplication become by electric passive transport of H+. In this sol. cell culture is possible. In 56%(9% (approx.) 56%) Saline sol. out of potential power of semipermeable memb. thick memb. be made, and the thick memb. can substituted for skin. Unnecessary cell can be removed without operation by memb. disfunction of Osmosis. And Transformation of tissue can be repaired by absorption press.

Priority: KR20040031376U Applic. Date: 2004-02-25

Inventor: KIM ARAN [KR]


Application No.: US20060029689A1  Published: 09/Feb/2006

Title: Skin protection composition

Applicant/Assignee: HOUOUDOU CO., LTD

Application No.: 11/246194   Filing Date: 11/Oct/2005

Abstract:The present invention provides: a skin protection composition that can effectively suppress intrusion of contagious bacteria such as Pseudomonas aeruginosa, Bacillus subtilis, Bacillus anthracis, Escherichia coli, Staphylococcus aureus, or MRSA, and viruses such as influenza virus from wounds, skin and mucosa such as those of the eyes, nose, throat, ears, anus and vagina into the body, and can also suppress growth of the bacteria and viruses

a skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria

a composition to prevent and/or treat bacterial and viral infections including hospital infections

an antiseptic

and a filter apparatus that can effectively suppress intrusion into the body and growth therein of contagious bacteria and viruses. The skin protection composition

skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria

composition to prevent and/or treat bacterial and viral infections including hospital infections

antiseptic

and filter apparatus that can effectively suppress intrusion into the body of contagious bacteria and viruses characterized by comprising Sasa extract, or Sasa extract and an organic acid as the active component.

Priority: WO2003JP04635 Applic. Date: 2003-04-11

Inventor: TSUCHIDA YUUZOU [JP]; TSUCHIDA KOTAROU [JP]; TSUCHIDA KENJIROU [JP]; WATANABE KUNITOMO [JP]; NAKAMURA YOSHIKO [JP]; IWASAWA ATSUO [JP]


Application No.: US20060030510A1  Published: 09/Feb/2006

Title: Detergent composition with benefit agents

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER CONOPCO, INC

Application No.: 11/197186   Filing Date: 04/Aug/2005

Abstract:A rinse off liquid or gel cleansing composition comprising a continuous phase comprising one or more detergent actives and a dispersed phase comprising one or more hydrophobic materials, the dispersed phase comprising a water soluble or dispersible benefit agent which is sensitive to a detergent active and/or high pH, which benefit agent is dispersed in the hydrophobic material.

Priority: IN2004MU00830 Applic. Date: 2004-08-04

Inventor: DABHOLKAR NANDINI S [IN]; KRISHNAN VENKARESWARAN [IN]; SHAH PANKAJ C [IN]; SIVAKUMAR ANANTHASUBRAMANIAN [IN]


Application No.: US20060034779A1  Published: 16/Feb/2006

Title: Foamable compositions containing vitamin D3 analogues, processes for preparing same and methods of treatment utilizng same

Applicant/Assignee: AGIS INDUSTRIES (1983) LTD

Application No.: 11/194521   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical foamable composition for topical application of vitamin D3 analogues such as calcipotriene and a process of manufacturing the same is disclosed. A method of treatment of skin and scalp disorders, especially of psoriasis or ear infections, by dispensing vitamin D3 analogues such as calcipotriene in a foamable composition is also disclosed.

Priority: US20040592380P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; ZEEVI AMIRA [IL]


Application No.: US20060034786A1  Published: 16/Feb/2006

Title: Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages

Applicant/Assignee: L'OREAL

Application No.: 11/202192   Filing Date: 12/Aug/2005

Abstract:Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

Priority: FR20030050023 Applic. Date: 2003-02-12; WO2004FR00325 Applic. Date: 2004-02-12; US20030456563P Applic. Date: 2003-03-24

Inventor: MICHELET JEAN-FRANCOIS [FR]; COMMO STEPHANE [FR]


Application No.: US20060034902A1  Published: 16/Feb/2006

Title: Microprojection apparatus and system with low infection potential

Applicant/Assignee:

Application No.: 11/201617   Filing Date: 10/Aug/2005

Abstract:A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.

Priority: US20040600638P Applic. Date: 2004-08-10

Inventor: CORMIER MICHEL J [US]; DADDONA PETER [US]; ANDERSON ROLFE [US]


Application No.: US20060034903A1  Published: 16/Feb/2006

Title: Apparatus and method for transdermal delivery of natriuretic peptides

Applicant/Assignee:

Application No.: 11/201625   Filing Date: 10/Aug/2005

Abstract:An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide-containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.

Priority: US20040600560P Applic. Date: 2004-08-11

Inventor: MAA YUH-FUN [US]; SELLERS SCOTT [US]; DADDONA PETER [US]; KAMBERI MARIKA [US]; GOPALAKRISHNAN VIDHYA [US]; SILBER B M [US]; STONEBANKS FRANK [US]


Application No.: US20060034904A1  Published: 16/Feb/2006

Title: Transdermal delivery using emcapsulated agent activated by ultrasound and or heat

Applicant/Assignee: ULTRA-SONIC TECHNOLOGIES, L.L.C

Application No.: 10/541001   Filing Date: 28/Jun/2005

Abstract:A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium ( 150 ) for holding the microcapsules

placing the medium for holding the microcapsules on a surface of a patch ( 100 ) adjacent the skin ( 320 ) of a human or animal

and applying energy ( 200 ) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.

Priority: US20020437541P Applic. Date: 2002-12-31; WO2003US41850 Applic. Date: 2003-12-31

Inventor: WEIMANN LUDWIG J [US]


Application No.: US20060034905A1  Published: 16/Feb/2006

Title: Adhesive composition

Applicant/Assignee:

Application No.: 11/198468   Filing Date: 04/Aug/2005

Abstract:An adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use as blister pads and wound dressings.

Priority: US20040599593P Applic. Date: 2004-08-05

Inventor: SINGH PARMINDER [US]; CLEARY GARY W [US]; KULICHIKHIN VALERY G [RU]; ANTONOV SERGEY [RU]


Application No.: US20060034952A1  Published: 16/Feb/2006

Title: Agent for inhibiting the growth of mammalian hair

Applicant/Assignee:

Application No.: 10/988804   Filing Date: 15/Nov/2004

Abstract:The present invention comprises of a composition for post-hair-removal topical application for inhibiting mammalian hair growth & application thereof. The present invention also embraces a method of inhibiting mammalian hair growth by applying an effective amount of the composition to the skin. The composition comprises of a hair growth-inhibiting agent and a dermatologically acceptable vehicle.

Priority: IN2004MU00873 Applic. Date: 2004-08-13

Inventor: KONDHALKAR MRINMAYEE B [IN]


Application No.: US20060035373A1  Published: 16/Feb/2006

Title: Stem cell libraries

Applicant/Assignee:

Application No.: 11/003840   Filing Date: 06/Dec/2004

Abstract:A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.

Priority: WO2003US34811 Applic. Date: 2003-10-31; US20020423041P Applic. Date: 2002-11-01; US20030454576P Applic. Date: 2003-03-13

Inventor: ZHANG HONGBING [US]; WILLIAMS LEWIS T [US]; CHU KETING [US]; COHEN FRED [US]


Application No.: US20060035893A1  Published: 16/Feb/2006

Title: Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/189643   Filing Date: 26/Jul/2005

Abstract:The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

Priority: EP20040018808 Applic. Date: 2004-08-07

Inventor: JUNG BIRGIT [DE]; HIMMELSBACH FRANK [DE]


Application No.: US20060036098A1  Published: 16/Feb/2006

Title: Carbonylamino-benzimidazole derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/533259   Filing Date: 29/Apr/2005

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair,

HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20020422914P Applic. Date: 2002-11-01; WO2003US34345 Applic. Date: 2003-10-28

Inventor: KIM YUNTAE [US]; HANNEY BARBARA [US]; DUGGAN MARK E [US]; SPENCER KEITH L [US]


Application No.: US20060036222A1  Published: 16/Feb/2006

Title: Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/915642   Filing Date: 10/Aug/2004

Abstract:Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates such as feces and menses. The skin care formulation comprises a bodily exudate modifying agent neutralizer to neutralize the possible negative effects on skin barrier function caused by the bodily exudate modifying agents coming into direct contact with the wearer's skin.

Priority:

Inventor: COHEN JASON C [US]; KOENIG DAVID W [US]; BROCK EARL D [US]; BARATIAN STEPHEN A [US]; CUNNINGHAM COREY [US]; BALDWIN STEPHEN [US]


Application No.: US20060036223A1  Published: 16/Feb/2006

Title: Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/915721   Filing Date: 10/Aug/2004

Abstract:Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates such as feces and menses. The skin care formulation comprises a film forming agent that, upon transfer to the skin, can form a continuous film layer on the skin to retard harmful agents.

Priority:

Inventor: BALDWIN STEPHEN [US]; CUNNINGHAM COREY [US]; COHEN JASON C [US]; KOENIG DAVID W [US]; BROCK EARL D [US]; BARATIAN STEPHEN A [US]


Application No.: US20060039881A2  Published: 23/Feb/2006

Title: COMPOSITIONS COMPRISING AT LEAST ONE ORGANIC POLYMER AND A MIXTURE OF VOLATILE AND NONVOLATILE SOLVENTS

Applicant/Assignee: L'OREAL S.A

Application No.: 10/621534   Filing Date: 17/Jul/2003

Abstract:Abstract of the Disclosure Compositions, for example cosmetic compositions, comprising at least one organic polymer, such as a crosslinked organosoluble polymer, and a mixture of at least two solvents, one of which is volatile and incompatible with the polymer, and the other of which is nonvolatile and compatible with the polymer. These compositions make it possible to form on keratin materials a deposit whose volume increases over time, without the intervention of an external stimulus. These compositions can be, for example, mascaras, lipsticks or anti-wrinkIe formulas in the form of a cream or a foundation. The cosmetic treatment processes using these compositions.

Priority: US2003-621534 Applic. Date: 2003-07-17; FR19990009265 Applic. Date: 1999-07-16; US2000-618031 Applic. Date: 2000-07-17

Inventor: FERRARI VERONIQUE [FR]; TOURNILHAC FLORENCE [FR]


Application No.: US20060039898A1  Published: 23/Feb/2006

Title: Method of skin care and/or treatment using rice (Oryza sativa) hemoglobin or other hexacoordinated, non-symbiotic plant hemoglobins

Applicant/Assignee:

Application No.: 11/190605   Filing Date: 27/Jul/2005

Abstract:Methods for the prevention and treatment of skin damage arising from exposure to nitric oxide and other pollutant oxidizing species, using rice (Oriza sativa) hemoglobin or other plant hexacoordinated, non-symbiotic hemoglobins, in a dermatologically acceptable carrier that can be topically applied to the skin areas, including lips. In some embodiments, other proteins such as superoxide dismutase and/or catalase or antioxidants are included.

Priority: US20040591340P Applic. Date: 2004-07-27

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]


Application No.: US20060039931A1  Published: 23/Feb/2006

Title: Stable cream preparations of phenyl-pyridone compounds for topical application

Applicant/Assignee: MEPHA AG

Application No.: 10/527555   Filing Date: 11/Mar/2005

Abstract:The invention relates to a pharmaceutical cream preparation for topical application in the form of an oil-in-water (o/w) emulsion, containing the following constituents in the lipophilic phase: (i) an optionally substituted 1-phenyl-2-(1H)-pyridone compound or a pharmaceutically acceptable salt thereof, as an active ingredient, (ii) at least one surface-active solubilising agent having an HLB value between 15 and 20, (iii) at least one emulsifier having an HLB value between 8 and 15, and (iv) optionally other carrier materials and additives known per se selected from the group containing triglycerides, penetration amplifiers, preserving agents and anti-oxidants. The invention also relates to the use of the preparation as a topical cream preparation for the treatment or prophylaxis of skin diseases.

Priority: CH20020001556 Applic. Date: 2002-09-13; WO2003CH00615 Applic. Date: 2003-09-11

Inventor: SCHEIWE MAX W [DE]; CENTIKAYA YALCIN [CH]


Application No.: US20060039936A1  Published: 23/Feb/2006

Title: Emulsification system for use in cosmetics

Applicant/Assignee: L'OREAL

Application No.: 10/920615   Filing Date: 18/Aug/2004

Abstract:Disclosed are cosmetic compositions containing water, at least one non-polar and/or polar oil, and an emulsification system comprising a polyoxyethylene oxide C12-C24 fatty acid ester

a sucrose fatty acid ester of vegetable origin, and a glyceryl and/or sorbitan C12-C24 fatty acid ester, and methods of making and using the compositions.

Priority:

Inventor: FARES HANI [US]; GROSSO RITA M [US]; FOLTIS SIDNEY PETER [US]; HANSENNE ISABELLE [US]


Application No.: US20060039938A1  Published: 23/Feb/2006

Title: Cosmetic method of caring for greasy skin

Applicant/Assignee: L'OREAL

Application No.: 11/204158   Filing Date: 16/Aug/2005

Abstract:The present invention relates to a cosmetic method of caring for greasy skin by topical application to the skin of a composition containing, in a physiologically acceptable medium suitable for topical application to the skin and containing an aqueous phase: (a) porous particles having an average diameter by volume of less than or equal to 10 mum and containing at least one active intended for the treatment of greasy skin and (b) particles of at least one sebum-absorbing and/or sebum-adsorbing compound having a number-average particle size of more than 10 mum.

Priority: FR20040008937 Applic. Date: 2004-08-17; US20040606128P Applic. Date: 2004-09-01

Inventor: JOSSE DELPHINE [FR]


Application No.: US20060039939A1  Published: 23/Feb/2006

Title: Associative thickeners for aqueous systems

Applicant/Assignee: LUBRIZOL ADVANCED MATERIALS, INC

Application No.: 11/206393   Filing Date: 18/Aug/2005

Abstract:Thiocarbonate compounds which, in one embodiment, are utilized as a rheology modifier or associative thickener. The thiocarbonate compounds thicken or increase the viscosity of a composition, preferably an aqueous composition when used in an effective amount. In one preferred embodiment, the thiocarbonate compounds include at least one hydrophilic group containing repeat unit such as derived from acrylic acid, and at least one hydrophobic group to enhance association with other compounds and thus increase viscosity of a composition. Aqueous composition comprising a latex and thiocarbonate associative thickeners are described.

Priority: US20040603448P Applic. Date: 2004-08-20

Inventor: LAI JOHN T [US]; HSU SHUI-JEN R [US]; TAMARESELVY KRISHNAN [US]


Application No.: US20060039961A1  Published: 23/Feb/2006

Title: Percutaneous absorption accelerator

Applicant/Assignee:

Application No.: 11/137883   Filing Date: 26/May/2005

Abstract:The present invention has as an object to provide a composition for external use on skin whose percutaneous absorption of an active component is increased, whereby a large amount of the active component can be delivered into the skin. By employing diglycerol and a low molecular weight betaine together, a percutaneous absorption accelerator excellent in permeability of an active component is provided. According to the percutaneous absorption accelerator of the present invention, the accelerated percutaneous absorption amount of an active component is greatly increased, whereby an effect which the active component essentially possesses is sufficiently exhibited.

Priority: JP20040160158 Applic. Date: 2004-05-28; CA20052508096 Applic. Date: 2005-05-20

Inventor: INAOKA SATOSHI [JP]; TSUNETSUGU SHUICHI [JP]


Application No.: US20060039972A1  Published: 23/Feb/2006

Title: Effervescent composition including a grape-derived component

Applicant/Assignee:

Application No.: 10/922075   Filing Date: 19/Aug/2004

Abstract:The invention features an effervescent composition that includes at least one grape-derived component, at least one effervescent agent, and optionally at least one active agent, where the sum of the weight of the grape-derived component and the weight of the active agent constitute at least about 10% by weight of the composition, with the weight of the grape-derived component being greater than weight of the active agent.

Priority:

Inventor: ALDRITT MARY [US]; LEE ROBERT E [US]; WEHLING FRED [US]


Application No.: US20060039978A1  Published: 23/Feb/2006

Title: Self-forming phospholipidic gels

Applicant/Assignee:

Application No.: 10/534746   Filing Date: 12/May/2005

Abstract:A phospholipid gel is spontaneously formed when combining a first phospholipid, a second phospholipid, and water, wherein the first phospholipid is a neutral phospholipid and the second phospholipid is a negatively charged phospholipid. The first and second phospholipids are of natural origin, semi-synthetic origin, or synthetic origin. Preferably, they are di(C8-C22 acyl) phosphatidyl choline and di(C8-C22 acyl) phosphatidyl glycerol. The total phospholipid concentration is within a range of 6-40% by weight.

Priority: DE20021055285 Applic. Date: 2002-11-26; WO2003DE03883 Applic. Date: 2003-11-24

Inventor: DIEDERICHS JULIA E [DE]


Application No.: US20060040836A1  Published: 23/Feb/2006

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 11/201377   Filing Date: 10/Aug/2005

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain sterically hindered amine salt compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US20040603590P Applic. Date: 2004-08-23

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MERVIN G [US]; MARTIN WANDA H [US]


Application No.: US20060040899A1  Published: 23/Feb/2006

Title: Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies

Applicant/Assignee:

Application No.: 11/121044   Filing Date: 04/May/2005

Abstract:Provided are compounds and methods for the prevention and treatment of autoimmune disorders and of allergies using such compositions in which autoantigens or allergens previously used for treating autoimmune disorders and allergies are used in combination with bisphosphonates or the derivatives thereof. Bisphosphonic acids and derivatives thereof generally corresponding to Formula I illustrated below are useful in the production of pharmaceutical formulations that may be used for the prevention and treatment of various autoimmune diseases or allergies. The bisphosphonic acids and the derivatives thereof which are used are those represented by the Formula I: in which the variables A1, A2, A3, A4, R1, R2 and X are selected from a range of substituents as outlined in the specification.

Priority: US2000-719946 Applic. Date: 2000-12-15

Inventor: JOMAA HASSAN [DE]


Application No.: US20060040914A1  Published: 23/Feb/2006

Title: Meso-substituted porphyrins

Applicant/Assignee: L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA DI ESERCIZIO S.P.A

Application No.: 10/532278   Filing Date: 21/Apr/2005

Abstract:Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitising agents, in particular in photodynamnic therapy, are herein described.

Priority: IT2002FI00200 Applic. Date: 2002-10-21; WO2003EP11642 Applic. Date: 2003-10-21

Inventor: RONCUCCI GABRIO [IT]; DEI DONATA [IT]; GIUNTINI FRANCESCA [IT]; CHITI GIACOMO [IT]; NISTRI DANIELE [IT]; FANTETTI LIA [IT]; PASCHETTA VALENTINA [IT]; COCCHI ANNALISA [IT]


Application No.: US20060040975A1  Published: 23/Feb/2006

Title: Fused ring NK1 antagonists

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/100226   Filing Date: 06/Apr/2005

Abstract:A compound having the general structure shown in Formula 1: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Priority: US20040560343P Applic. Date: 2004-04-07

Inventor: XIAO DONG [US]; PALANI ANANDAN [US]; WANG CHENG [US]; TSUI HON-CHUNG [US]; SHIH NENG-YANG [US]; REICHARD GREGORY A [US]


Application No.: US20060041016A1  Published: 23/Feb/2006

Title: Composition and method for the treatment of psoriasis

Applicant/Assignee:

Application No.: 11/204491   Filing Date: 16/Aug/2005

Abstract:The use of a prostaglandin A2 derivative, and prodrugs of the compound, for the manufacture of a medicament for the treatment and/or alleviation of psoriasis is presented, as well as a method of treatment, involving the topical application of such prostaglandins. Compositions containing a therapeutically active, and physiologically acceptable amount of the above compound or derivatives thereof, as such or in the form of a prodrug, in a suitable vehicle are also described. Importantly, the derivatives can be applied in therapeutically active amounts without or with only minimal side effects, such as hyperemia, irritation or pain.

Priority: SE20040002029 Applic. Date: 2004-08-17

Inventor: STJERNSCHANTZ JOHAN [FI]; RESUL BAHRAM [SE]


Application No.: US20060041248A1  Published: 23/Feb/2006

Title: Pharmaceutical compositions delivery system and methods

Applicant/Assignee:

Application No.: 10/923937   Filing Date: 23/Aug/2004

Abstract:A method, system and applicator for the solvent-less delivery of a bio-active material to a receiver. The applicator includes a discharge device, a reservoir which holds a bioactive material, and a solvent at a supercritical fluid state for delivering the bioactive material through the discharge device to the receiver. A spacer may be positioned between the discharge device and the receiver. The receiver may have a plurality of different bio-active material to be applied to a subject, each located at a different location on the receiver.

Priority:

Inventor: PATTON DAVID L [US]; SPOONHOWER JOHN P [US]; NELSON DAVID J [US]; POCHAN JOHN M [US]; KEEFE TIMOTHY [US]; REED KENNETH J [US]; MEHTA RAJESH V [US]; JAGANNATHAN RAMESH [US]


Application No.: US20060045857A1  Published: 02/Mar/2006

Title: Sunless tanning composition and methods for using

Applicant/Assignee:

Application No.: 10/933128   Filing Date: 02/Sep/2004

Abstract:A sunless tanning composition is provided according to the invention. The sunless tanning composition includes a polymer component, a tanning active component, water, and the composition is provided as an emulsion and has a viscosity of less than about 25 cSt. A method for using a sunless tanning composition is provided.

Priority:

Inventor: ROSZELL JAMES A [US]


Application No.: US20060045858A1  Published: 02/Mar/2006

Title: Composition and method for reducing harmful effects of ultraviolet radiation impinging on the skin

Applicant/Assignee:

Application No.: 11/211191   Filing Date: 25/Aug/2005

Abstract:A composition is provided that is suitable for topical administration for the treatment of skin to reduce the harmful effects of ultraviolet radiation impinging on the skin, the composition comprising acetylsalicylic acid and sodium bicarbonate. Also provided is a method for treating skin to reduce the harmful effects of ultraviolet radiation impinging on the skin comprising topically administering to the skin a therapeutically effective amount of a composition comprising acetylsalicylic acid and sodium bicarbonate. Also provided is an aqueous composition suitable as an additive to a composition of cosmetics comprising acetylsalicylic acid and sodium bicarbonate. Also provided is a method of manufacturing a cosmetic composition, comprising obtaining an aqueous composition that includes acetylsalicylic acid and sodium bicarbonate, and combining the aqueous composition with cosmetic ingredients to create the cosmetic composition.

Priority: US20040604888P Applic. Date: 2004-08-26

Inventor: FULLER PETER E [US]


Application No.: US20060045859A1  Published: 02/Mar/2006

Title: S-triazine sunscreens bearing hindered para-aminobenzalmalonate/para-aminobenzalmalonamide and aminobenzoate/aminobenzamide substituents

Applicant/Assignee:

Application No.: 11/214865   Filing Date: 31/Aug/2005

Abstract:Novel s-triazine sunscreens have the structural formula (I): and are formulated into cosmetic/dermatological photoprotective compositions useful for photoprotecting keratinous substances against the damaging effects of UV-radiation.

Priority: FR20040009292 Applic. Date: 2004-09-02; US20040614210P Applic. Date: 2004-09-30

Inventor: RICHARD HERVE [FR]; LEJUSTE CATHERINE [FR]


Application No.: US20060045861A1  Published: 02/Mar/2006

Title: Reduced odor in low molecular weight cationic polygalactomannan

Applicant/Assignee:

Application No.: 11/202469   Filing Date: 12/Aug/2005

Abstract:A reduced odor composition is composed of at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a weight average molecular weight (Mw) having a lower limit of 5,000 and an upper limit of 200,000, a light transmittance in a 10% aqueous solution of greater than 80% at a light wavelength of 600 nm, a protein content of less than 1.0% by weight of polysaccharide, and a trimethylamine content of less than 25 ppm in a 10% aqueous solution of the polymer. This composition is prepared by treating the polymer with reagents that reduce the molecular weight of the polymer, removing the water-insoluble solid material, and removing odorous components, including trimethylamine (TMA) and other amines and low molecular weight components from the aqueous phase to produce a polymer that when used in a functional system such as household care, personal care or pet care products has reduced or no odor at acidic, neutral, or alkaline pH values.

Priority: US20040605556P Applic. Date: 2004-08-31

Inventor: BEJGER THOMAS P [US]; ERAZO-MAJEWICZ PAQUITA [US]; HOPKINS DANIEL L [US]; KOSTAS JOHN N [US]; KUO PONG-KUEN P [US]; MODI JASHAWANT J [US]; XU ZU-FENG [US]


Application No.: US20060045890A1  Published: 02/Mar/2006

Title: Topical skin care compositions

Applicant/Assignee:

Application No.: 10/928823   Filing Date: 27/Aug/2004

Abstract:A novel combination of silicon resin, amorphous silica and low oil absorbing spherical powder is described which when added to topical skin care compositions containing high concentrations of active agents, improves their aesthetic feel and ease of application.

Priority:

Inventor: GONZALEZ ANTHONY D [US]; HUBBARD BARBARA J [US]; ANDERSON GLEN [US]; KALAFSKY ROBERT E [US]


Application No.: US20060045892A1  Published: 02/Mar/2006

Title: Cosmetic compositions

Applicant/Assignee: MOLECULAR RESEARCH CENTER, INC

Application No.: 10/925851   Filing Date: 25/Aug/2004

Abstract:A composition and method for improving skin appearance by reducing skin redness and symptoms associated with skin inflammation, irritation and skin aging by topically treating skin is disclosed. In this composition and method, an active material having the formula given below is applied to the patient at the site of said condition: wherein R<1 >is selected from -OH and C1-C3 alkyl OH

and R<2>, R<3>, R<4>, R<5 >and R<6 >are independently selected from -H, -OH, C1-C6 alkyl, and C3-C6 cycloalkyl. The active material should contain no more than five -OH groups. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures of those materials. A method of maintaining healthy hair and reducing hair loss using these actives is also disclosed.

Priority:

Inventor: CHOMCZYNSKI PIOTR [US]


Application No.: US20060045894A1  Published: 02/Mar/2006

Title: Compound for neck skin firming

Applicant/Assignee:

Application No.: 10/932690   Filing Date: 01/Sep/2004

Abstract:A topical compound for reducing sagging or wrinkles in the neck area of human skin. The compound includes safe and effective amounts of a mild topical astringent (such as Camphor) for skin tightening, a topical antispasmodic (such as benzyl cinnamate) for skin smoothing, and a topical skin irritant to increase localized skin circulation. The compound can also optionally include palmitoyl pentapeptide-3 to stimulate production of collagen and elastin in skin, a mushroom ferment extract to increase the cell turnover rate skin, and to increase hydration, skin firmness and elimination of fine facial lines, a cocao ferment extract to inhibit lipid peroxidation, inhibit excess ornithine decarboxylase activity, and stimulate cutaneous blood flow to reduce lines and wrinkles, and a Lactobacillus lysate extract to stimulate collagen production. These ingredients are mixed in a dermatologically acceptable carrier for topical application.

Priority:

Inventor: BROWN VERA [US]; FISHMAN YORUM [US]


Application No.: US20060046250A1  Published: 02/Mar/2006

Title: Novel use of aim 3 acting as a tumor suppressor

Applicant/Assignee:

Application No.: 10/536257   Filing Date: 25/May/2005

Abstract:The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.

Priority: WO2004KR02202 Applic. Date: 2004-09-01

Inventor: KIM SUNGHOON [KR]


Application No.: US20060046943A1  Published: 02/Mar/2006

Title: Functional systems with reduced odor cationic polygalactomannan

Applicant/Assignee:

Application No.: 11/211001   Filing Date: 24/Aug/2005

Abstract:A reduced odor composition is composed of a functional system such as household care, personal care or pet care products and at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a cationic degree of substitution (DS) lower limit of about 0.01 and an upper limit of about 3.0 and weight average molecular weight (Mw) having a lower limit of 200,000 and an upper limit of 2,000,000 a concentration with a lower limit of 0.005 wt % and an upper limit of 10 wt %, and a trimethylamine content of less than 25 ppm, wherein the composition, at an alkaline pH, has no discernible amine odor.

Priority: US20040605556P Applic. Date: 2004-08-31

Inventor: ERAZO-MAJEWICZ PAQUITA [US]; MODI JASHAWANT M [US]


Application No.: US20060051305A1  Published: 09/Mar/2006

Title: Methods of producing lignin peroxidase and its use in skin and hair lightening

Applicant/Assignee: R.B.T. (RAKUTO BIO TECHNOLOGIES) LTD

Application No.: 10/538778   Filing Date: 10/Jun/2005

Abstract:Methods of producing lignin peroxidase are provided. Also provided are methods and cosmetic compositions suitable for skin and hair lightening as well as kits and an article-of manufacturing including active ingredients for skin and hair lightening.

Priority: US20020432678P Applic. Date: 2002-12-12; WO2003IL01055 Applic. Date: 2003-12-11

Inventor: BELINKY PAULA [IL]; LASSER HAIM [IL]; DOSORETZ CARLOS [IL]


Application No.: US20060051339A1  Published: 09/Mar/2006

Title: Composition for treatment of oily skin and acne prevention and methods of making and using same

Applicant/Assignee:

Application No.: 11/221431   Filing Date: 08/Sep/2005

Abstract:Compositions and methods for the prevention and treatment of oily skin and the prevention and treatment of open comedos and acne using the enzyme lipase and an acceptable carrier are disclosed.

Priority: US20040608015P Applic. Date: 2004-09-08

Inventor: SIVAK HANNAH N [US]


Application No.: US20060051366A1  Published: 09/Mar/2006

Title: Use of soluble CD26 as inhibitor of angiogenesis and inflammation

Applicant/Assignee:

Application No.: 11/208288   Filing Date: 18/Aug/2005

Abstract:The present invention relates to soluble CD26 or a biologically active variant of the soluble CD26 that effectively inhibits angiogenesis and inflammation in a mammalian subject, pharmaceutical compositions comprising the soluble CD26 and the use of soluble CD26 in methods of treatment.

Priority: US20040605013P Applic. Date: 2004-08-26

Inventor: CHANG CHIWEN [GB]


Application No.: US20060051425A1  Published: 09/Mar/2006

Title: Method of microencapsulation

Applicant/Assignee: TAGRA BIOTECHNOLOGIES LTD

Application No.: 11/208007   Filing Date: 22/Aug/2005

Abstract:The present invention provides methods for microencapsulation of active ingredients for topical application, whereby single-layer and multi-layer, preferably double-layer, microcapsules, are obtained. The microcapsules protect the active ingredients, maintain their original activity throught processing, formulation and storage, and enable controlled release of the active ingredient only upon application onto the skin.

Priority: GB19990027202 Applic. Date: 1999-11-17; US2002-130529 Applic. Date: 2002-09-30; WO2000IL00759 Applic. Date: 2000-11-16

Inventor: KVITNITSKY EMMA [IL]; SHAPIRO YURY [IL]; PRIVALOV OLGA [IL]; OLEINIK IRENA [IL]; POLISHER IGOR [IL]


Application No.: US20060051439A1  Published: 09/Mar/2006

Title: Antioxidant, skin preparation for external use, cosmetic and food

Applicant/Assignee: NICHIREI BIOSCIENCES INC

Application No.: 10/535382   Filing Date: 22/Jul/2005

Abstract:The invention relates to antioxidants that make effective use of acerola seeds, which have conventionally been discarded, that have high safety and excellent antioxidative effect in skin preparations for external use, cosmetics, and food, and that contain acerola seed extract as an active component. The invention also relates to skin preparations for external use, cosmetics, and food containing the antioxidant.

Priority: JP20020341191 Applic. Date: 2002-11-25; WO2003JP14885 Applic. Date: 2003-11-21

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]


Application No.: US20060052276A1  Published: 09/Mar/2006

Title: Perfume compositions

Applicant/Assignee:

Application No.: 10/521449   Filing Date: 14/Jan/2005

Abstract:A perfume composition comprising a perfume component capable of inhibiting the production of odoriferous steroids by micro-organisms on the skin. The perfume component is capable of inhibiting the biotransformation of androstadienols to androstenones.

Priority: GB20020016633 Applic. Date: 2002-07-18; GB20020027740 Applic. Date: 2002-11-28; WO2003GB03083 Applic. Date: 2003-07-16

Inventor: PERRING KEITH D [GB]; BRADSHAW DAVID J [GB]; BEHAN JOHN M [GB]; CAWKILL PAULA M [GB]


Application No.: US20060052287A1  Published: 09/Mar/2006

Title: Polyethylene glycol - peptide copper complexes and compositions and methods related thereto

Applicant/Assignee: PROCYTE CORPORATION

Application No.: 11/204772   Filing Date: 16/Aug/2005

Abstract:This invention relates to compositions comprising polyethylene glycol molecules coupled to peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

Priority: US20040602715P Applic. Date: 2004-08-18

Inventor: PATT LEONARD M [US]


Application No.: US20060052296A1  Published: 09/Mar/2006

Title: Method of cell growth inhibition with agnoprotein

Applicant/Assignee: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OFHIGHER EDUCATION

Application No.: 10/517710   Filing Date: 27/Jul/2005

Abstract:The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the absence of any other polyoma virus protein or viral replication.

Priority: US20020388019P Applic. Date: 2002-06-12; WO2003US18519 Applic. Date: 2003-06-11

Inventor: KHALILI KAMEL [US]


Application No.: US20060052318A1  Published: 09/Mar/2006

Title: Tyrosinase activity cntrolling agent, process for producing the same and external preparations containing the same

Applicant/Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY TOYO BOSEKI KABUSHIKI KAISHA

Application No.: 10/530789   Filing Date: 08/Apr/2005

Abstract:Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.

Priority: JP20020297040 Applic. Date: 2002-10-10; JP20020353403 Applic. Date: 2002-12-05; JP20030117973 Applic. Date: 2003-04-23; JP20030294543 Applic. Date: 2003-08-18; WO2003JP13018 Applic. Date: 2003-10-10

Inventor: TOKIWA YUTAKA [JP]; KITAGAWA MASARU [JP]; YOSHINO KENJI [JP]; YANAGIDANI SHUSAKU [JP]; RAKU TAKAO [JP]; TOTANI TETSUZO [JP]; SHIMAKAWA HIROMI [JP]


Application No.: US20060052322A1  Published: 09/Mar/2006

Title: Combination treatment of cancer with elicitor of gene product expression and gene-product targeting agent

Applicant/Assignee: INTROGEN THERAPEUTICS, INC

Application No.: 11/150521   Filing Date: 10/Jun/2005

Abstract:The present invention concerns cancer therapy employing an expression construct that affects regulation of one or more particular nucleic acid sequences that encodes a gene product to which an agent is then targeted. In specific embodiments, the present invention relates to the use of p53 gene therapy to treat cancers in combination with Erbitux(TM)(cetuximab). Viral and non-viral gene delivery systems are disclosed.

Priority: US20040579036P Applic. Date: 2004-06-11

Inventor: ROTH JACK A [US]; SCHUMACHER GUIDO [DE]; CHADA SUNIL [US]


Application No.: US20060052375A1  Published: 09/Mar/2006

Title: Bis-alkylbenzylamines

Applicant/Assignee:

Application No.: 10/531232   Filing Date: 13/Apr/2005

Abstract:Compounds of Formula (1), wherein R1 is hydrogen

C1-C18alkyl

trifluoromethyl

C3-C8cycloalkyl

phenylC1-C5alkyl

phenyl-C1-C5alkoxy

mono- or di-N-C1-C5alkamino-C1-C5alkyl

amino-di-N-C1-C5alkylamino-C1-C5alkyl

C1-C5alkoxy-C1-C5alkyl

R2 is C2-C20alkyl

hydroxy-C1-C20alkyl

phenyl

phenyl-C1-C5alkyl

phenyl-C1-C5alkoxy

mono- or di-N-C1-C5alkylamino-C1-C5alkyl

amino-di-N-C1-C5alkylamino-C1-C5alkyl

or heteroaryl-C1-C5alkyl

or R1 and R2 together with the nitrogen atom bonding them form a 5- to 7-membered monocyclic heterocyclic ring

are described. They are suitable for the antimicrobial treatment of surfaces, especially as antimicrobial active ingredients against gram-positive and gram-negative bacteri

Priority: EP20020405898 Applic. Date: 2002-10-21; CH20030000091 Applic. Date: 2003-01-22; WO2003EP11384 Applic. Date: 2003-10-14

Inventor: MARQUAIS-BIENEWALD SOPHIE [FR]; HOLZL WERNER [FR]; PREUSS ANDREA [CH]; MEHLIN ANDREAS [DE]; BRUNNER FREDERIC [CH]


Application No.: US20060052405A1  Published: 09/Mar/2006

Title: Hair loss prevention

Applicant/Assignee:

Application No.: 11/208864   Filing Date: 22/Aug/2005

Abstract:Compositions to prevent or reduce hair loss, allowing the body to maintain normal, healthy hair growth, comprising a penetration enhancer together with a testosterone blocker or a vascular enhancer, or both.

Priority: US2000-619142 Applic. Date: 2000-07-19

Inventor: KNOWLES W R [US]


Application No.: US20060052406A1  Published: 09/Mar/2006

Title: Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor

Applicant/Assignee: ISREAL INSTITUTE FOR BIOLOGICAL RESEARCH ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

Application No.: 10/512673   Filing Date: 08/Jul/2005

Abstract:There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

Priority: US20020377433P Applic. Date: 2002-05-03; WO2003IL00357 Applic. Date: 2003-05-01

Inventor: FISHER ABRAHAM [IL]; BAR-NER NIRA [IL]; KARTON YISHAI [IL]


Application No.: US20060052410A1  Published: 09/Mar/2006

Title: 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents

Applicant/Assignee: WYETH

Application No.: 11/219940   Filing Date: 06/Sep/2005

Abstract:This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I:

Priority: US20040607766P Applic. Date: 2004-09-07

Inventor: VU AN T [US]


Application No.: US20060057075A1  Published: 16/Mar/2006

Title: Pharmaceutical and cosmeceutical wash-off mousse shampoo compositions, processes for preparing the same and uses thereof

Applicant/Assignee:

Application No.: 11/194582   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical mousse shampoo composition formulated for application to hirsute areas, such as the human scalp, and containing an active pharmaceutical ingredient as well as a cleansing agent is disclosed. Methods of treatment using the same and processes of preparing the same are also disclosed.

Priority: US20040592405P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; ZEEVI AMIRA [IL]; AVRAM NIR [IL]; UZAN RINA [IL]; SHILO-VOLIN HAGIT [IL]; HOLLANDER EREZ [IL]; BURIAKOVSKY OLGA [IL]


Application No.: US20060057092A1  Published: 16/Mar/2006

Title: Cosmetic use of a composition including an ascorbic acid compound and polyamide particles

Applicant/Assignee: L'OREAL

Application No.: 11/224959   Filing Date: 14/Sep/2005

Abstract:The present invention relates to the cosmetic use, for the care of greasy skin, of a composition including, in a physiologically acceptable medium, (a) at least one water-soluble ascorbic acid compound and (b) porous polyamide particles having a mean diameter, by volume, of less than or equal to 10 mum, provided that the composition is not a water-in-oil emulsion.

Priority: FR20040052074 Applic. Date: 2004-09-16; US20040612875P Applic. Date: 2004-09-27

Inventor: MARION CATHERINE [FR]


Application No.: US20060057110A1  Published: 16/Mar/2006

Title: Antigen-presenting cells for neuroprotection and nerve regeneration

Applicant/Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 10/517666   Filing Date: 13/Dec/2004

Abstract:Pharmaceutical compositions and methods for preventing or inhibiting neuronal degeneration, or for promoting nerve regeneration, in the central nervous system (CNS) or peripheral nervous system (PNS), in the treatment of an injury, disorder or disease of the CNS or PNS, comprise antigen-presenting cells, preferably dendritic cells, that have been pulsed with an agent selected from the group consisting of: (a) a nervous system (NS)-specific antigen or an analog thereof

(b) a peptide derived from an NS-specific antigen or from an analog thereof, or an analog or derivative of said peptide

(c) a copolymer selected from the group consisting of Copolymer 1, a Copolymer 1-related peptide or polypeptide, and poly-Glu<50> Tyr<50>

and (d) a non-self antigen.

Priority: US20020388296P Applic. Date: 2002-06-14; WO2003IL00500 Applic. Date: 2003-06-12

Inventor: EISENBACH-SCHWARTZ MICHAL [IL]; COHEN AVRAHAM [IL]


Application No.: US20060057113A1  Published: 16/Mar/2006

Title: Novel adenoviruses, nucleic acids coding therefor, and use thereof

Applicant/Assignee:

Application No.: 10/531366   Filing Date: 14/Apr/2005

Abstract:The present invention is related to an adenovirus expressing a first protein which is selected from the group comprising an E1B protein and an E4 protein, priorto a second protein which is selected from the group comprising an E1A protein.

Priority: DE20021048039 Applic. Date: 2002-10-15; DE20031022530 Applic. Date: 2003-05-19; DE20031024085 Applic. Date: 2003-05-27; WO2003EP05583 Applic. Date: 2003-05-27; WO2003EP11427 Applic. Date: 2003-10-15

Inventor: HOLM PER S [DE]


Application No.: US20060057168A1  Published: 16/Mar/2006

Title: Microemulsion process and composition

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/216668   Filing Date: 31/Aug/2005

Abstract:There is provided a process for the preparation of an oil in water (O/W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the method including the steps of a) Admixing a first part including at least one of the group consisting of animal, mineral or vegetable oils, silanes, siloxanes, esters, fatty acids, fats, halogen compounds or alkoxylated alcohols

and one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40-99 DEG C., preferably 45-95 DEG C., more preferably 65-85 DEG C. with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2 DEG C. and said phase assembly temperature, said third part if necessary being premixed and heated until the components are dissolved and including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water it also includes a non-surfactant amphiphilic type compound and/or surfactant. The phase assembly temperature can be determined visually by the achievement of translucence in the composition or by measures such as conductivity which peaks and then is maintained at a plateau whilst phase assembly occurs. It has been found that whilst if a non-surfactant amphiphilic type compound such as the polyol is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

Priority: US20050670722P Applic. Date: 2005-04-12; US20040606278P Applic. Date: 2004-08-31

Inventor: LARM MARIA G [AU]; HARDING RONALD [AU]


Application No.: US20060057175A1  Published: 16/Mar/2006

Title: Broad spectrum preservation blends

Applicant/Assignee: ARCH CHEMICALS, INC

Application No.: 11/224397   Filing Date: 12/Sep/2005

Abstract:A composition having effective broad spectrum preservation activity comprising a mixture of caprylyl glycol or one or more analogs thereof, or mixtures thereof with a preservative selected from the group consisting of: (1) chloroxylenol and 2-phenoxyethanol, (2) chloroxylenol and chlorphenesin, (3) chlorphenesin and 2-phenoxyethanol, and (4) chloroxylenol, chlorphenesin and 2-phenoxyethanol.

Priority: US20040610772P Applic. Date: 2004-09-16

Inventor: CICCOGNANI DIANA T [US]; DINICOLA KEVIN N [US]; HINDEN STEPHEN D [US]; ROBERTS KATHERINE P [US]


Application No.: US20060057229A1  Published: 16/Mar/2006

Title: External skin preparations for suppressing sebum secretion

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 11/270438   Filing Date: 10/Nov/2005

Abstract:A drug for external application to the skin, for inhibiting sebum secretion, comprising a matrix metalloproteinase inhibitor.

Priority: JP20000197309 Applic. Date: 2000-05-26; JP20010151391 Applic. Date: 2001-05-21; US2002-277000 Applic. Date: 2002-11-20; WO2001JP04336 Applic. Date: 2001-05-23

Inventor: INOMATA SHINJI [JP]; KOBAYASHI KOJI [JP]


Application No.: US20060057237A1  Published: 16/Mar/2006

Title: Extract with anti-tumor and anti-poisonous activity

Applicant/Assignee:

Application No.: 10/530905   Filing Date: 08/Apr/2005

Abstract:Extracts of the plant Calotropis procera, having a pharmacological activity, in particular an anti-poisonous activity, and active compounds isolated thereof are described. Furthermore, methods for the extraction of the extracts are disclosed. Also, a pharmaceutical composition or product for the treatment of cancer which includes an effective amount of the described extracts or an active compound thereof, a therapeutic compound and optionally a pharmaceutical acceptable carrier are described.

Priority: WO2002EP11310 Applic. Date: 2002-10-09; WO2003EP11192 Applic. Date: 2003-10-09

Inventor: DARRO FRANCIS [BE]; BRAEKMAN JEAN-CLAUDE [BE]; GUISSOU PIERRE [BF]; NACOULMA ODILE G [BF]; EL YAZIDI MOHAMED [BE]; DEWELLE JANIQUE [BE]; VAN GINKEL ROB [BE]; VAN DAMME MARC [BE]; KISS ROBERT [BE]


Application No.: US20060062832A1  Published: 23/Mar/2006

Title: Sanitizing wipes with microbicidal properties cross-reference to related applications

Applicant/Assignee:

Application No.: 11/130455   Filing Date: 16/May/2005

Abstract:A biodegradable sanitizing and microbicidal wipe composition using food additive ingredients or ingredients regarded as safe by the FDA. The wipes hereof are safe for sanitizing and disinfecting food, food contact, and environmental surfaces and skin, hands and other body parts.

Priority: US20040611559P Applic. Date: 2004-09-20

Inventor: LOPES JOHN A [US]


Application No.: US20060062837A1  Published: 23/Mar/2006

Title: Dual activating TDD

Applicant/Assignee:

Application No.: 10/945658   Filing Date: 21/Sep/2004

Abstract:Preferred embodiment FIG. 1 , comprises a novel transdermal delivery device for ensuring longer shelf life of unstable drugs comprising a patch for disbursement of therapeutic drugs to the skin of a user

said patch comprising an inbuilt injection port in which the user injects the diluent and/or active ingredient(s) into the drug reservoir to activate said drug delivery device, wherein the device comprises various permeablity rate-controlling membranes to accommodate a specific drug being introduced to the device, wherein upon removing the protective outer layer, of the preferred embodiment FIG. 1 . the device is ready to be placed on the skin by the patient. Additional embodiment replaces the injection port with a separate sealed diluent pouch reservoir.

Priority:

Inventor: PUTMAN ROGER T SR [US]


Application No.: US20060062838A1  Published: 23/Mar/2006

Title: BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY

Applicant/Assignee: CHRONO THERAPEUTICS, INC

Application No.: 11/162525   Filing Date: 13/Sep/2005

Abstract:Systems and methods for treating diseases, addictions and disorders in humans and animals involving synchronizing and tailoring the administration of drug compounds with the body's natural circadian rhythms, in order to counteract symptoms when they are likely to be at their worst. Automated and pre programmable transdermal drug administration system are used. This system can also utilize a pump or pressurized reservoir, and/or a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with micro-fabricated structures commonly referred to as Micro-needles, or heat, or iontophoresis, sonophoresis, or a wide range of chemical permeation enhancers.

Priority: US20040609418P Applic. Date: 2004-09-13; US2005-162517 Applic. Date: 2005-09-13

Inventor: DIPIERRO GUY [US]; GIANNOS STEVEN A [US]


Application No.: US20060062859A1  Published: 23/Mar/2006

Title: Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes

Applicant/Assignee:

Application No.: 11/197980   Filing Date: 05/Aug/2005

Abstract:The present invention relates to a composition and custom business model and methods to measure genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplements with custom formulations to optimize health outcomes.

Priority: US20040599829P Applic. Date: 2004-08-05

Inventor: BLUM KENNETH [US]; MESHKIN BRIAN [US]; DOWNS BERNARD W [US]


Application No.: US20060063235A1  Published: 23/Mar/2006

Title: DNA encoding the human serine protease C-E

Applicant/Assignee:

Application No.: 10/988164   Filing Date: 12/Nov/2004

Abstract:Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.

Priority: US2002-040803 Applic. Date: 2002-01-07; US1999-386629 Applic. Date: 1999-08-31

Inventor: DARROW ANDREW [US]; QI JENSON [US]; ANDRADE-GRODON PATRICIA [US]


Application No.: US20060063732A1  Published: 23/Mar/2006

Title: Compositions and methods for gene therapy

Applicant/Assignee:

Application No.: 11/253435   Filing Date: 18/Oct/2005

Abstract:The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.

Priority: US2002-220983 Applic. Date: 2002-12-12; WO2001US09618 Applic. Date: 2001-03-23; US20000191902P Applic. Date: 2000-03-24

Inventor: VOGEL JEAN-MARIE [US]; BOSCHETTI EGISTO [FR]


Application No.: US20060063835A1  Published: 23/Mar/2006

Title: Composition based on triethyl citrate for the treatment of bacterial infections of the skin

Applicant/Assignee:

Application No.: 10/526152   Filing Date: 24/Feb/2005

Abstract:This invention concerns a composition for topical use containing as an active ingredient triethyl citrate either pure or in combination with synergists, and the pharmaceutical or cosmetic use of the composition, on its own or in association with an antibiotic, at least in the treatment of cutaneous pathologies directly or indirectly affected by bacterial infections.

Priority: IT2002BS00078 Applic. Date: 2002-09-02; WO2003IT00530 Applic. Date: 2003-09-02

Inventor: DE PAOLI AMBROSI GIANFRANCO [IT]


Application No.: US20060063856A1  Published: 23/Mar/2006

Title: Washable marker ink composition

Applicant/Assignee: MATTEL, INC

Application No.: 10/944980   Filing Date: 20/Sep/2004

Abstract:The present invention provides a fluorescent marker ink coloring composition incorporating an optical brightener, a film-forming agent, an aqueous carrier, and a colorant. The optical brightener is an amphoteric distyryl fluorescent whitener which generates a special effect in the dried marking ink composition. The coloring composition can optionally include one or more of a humectant, a surfactant, a preservative, a drying agent, a pH regulant, a bittering agent or a fragrance. The present invention further provides a writing instrument comprising the coloring composition.

Priority:

Inventor: CORDOVA ABIMAEL [US]


Application No.: US20060064068A1  Published: 23/Mar/2006

Title: Film-forming compositions for protecting skin from body fluids and articles made therefrom

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/273355   Filing Date: 14/Nov/2005

Abstract:The present invention relates to a film-forming barrier composition useful for protecting the skin from body fluids, such as urine, feces, menses. The composition comprises a skin conditioning agent, a viscosity enhancing agent and an oleophilic film-forming agent. Optionally, the lotion may comprise skin care ingredients for treating or maintaining skin health. The composition may be applied to the skin by suitable delivery vehicles, such as absorbent articles or components thereof, sheet materials, pads, bandages, sponges, foam pads, pumps, sprays, depending on the viscosity of the composition.

Priority: US2001-898880 Applic. Date: 2001-07-03

Inventor: KLOFTA THOMAS J [US]; STAUDIGEL JAMES A [US]; DECKNER GEORGE E [US]


Application No.: US20060067893A1  Published: 30/Mar/2006

Title: UV-absorbing lipid vesicles

Applicant/Assignee: GALAXY SURFACTANTS LIMITED

Application No.: 10/953832   Filing Date: 29/Sep/2004

Abstract:Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher levels of photoprotection to skin and hair. The vesicular compositions of the present invention are made from cationic UV-absorbing lipids of Formula I wherein,

Priority:

Inventor: KOSHTI NIRMAL M [IN]; NAIK SHUBHANGI D [IN]; JADHAV TANAJI S [IN]


Application No.: US20060067894A1  Published: 30/Mar/2006

Title: Film foaming hydroalcoholic foam

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/187217   Filing Date: 22/Jul/2005

Abstract:The present invention provides a foam composition comprising an active agent. In particular, the foam composition produces a water resistant, preferably very water resistant, film upon application.

Priority: WO2004AU00170 Applic. Date: 2004-02-12; US20030447445P Applic. Date: 2003-02-12

Inventor: HUGGINS JOAN K [AU]; HOULDEN ROBERT J [AU]


Application No.: US20060067901A1  Published: 30/Mar/2006

Title: Antiperspirant compositions

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 10/952949   Filing Date: 29/Sep/2004

Abstract:What is described herein is an antiperspirant composition including an active antiperspirant ingredient, and a phenylethyl, benzyl or substituted benzyl ester as additive therein, which is an aryl carboxylic ester of 2-phenylethyl alcohol, 1-phenylethyl alcohol or benzyl alcohol, which leaves a reduced visible white chalky residue on the skin of the user.

Priority:

Inventor: BERTZ STEVEN H [US]; OROFINO STEVEN A [US]; GOMEZ BLANCA [US]


Application No.: US20060067927A1  Published: 30/Mar/2006

Title: Methods and compositions related to the modulation of intercellular junctions

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 11/171490   Filing Date: 29/Jun/2005

Abstract:The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

Priority: US20040584438P Applic. Date: 2004-06-29

Inventor: CHANDRASEKARAN AARTHI [US]; SENGUPTA SHILADITYA [US]; BERRY DAVID A [US]; HOLLEY KRISTINE [US]; ZHAO GANLIN [US]; SASISEKHARAN RAM [US]


Application No.: US20060067943A1  Published: 30/Mar/2006

Title: Stabilization of alum-adjuvanted immunologically active agents

Applicant/Assignee:

Application No.: 11/237200   Filing Date: 27/Sep/2005

Abstract:A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.

Priority: US20040614161P Applic. Date: 2004-09-28; US20050649275P Applic. Date: 2005-01-31

Inventor: MAA YUH-FUN [US]; SELLERS SCOTT [US]


Application No.: US20060067957A1  Published: 30/Mar/2006

Title: Self-heating cosmetic products

Applicant/Assignee:

Application No.: 10/542536   Filing Date: 18/Jul/2005

Abstract:The invention refers to cosmetic products having a self-warming effect. The composition is substantially water-free and contains 0.1 to 40% by weight of a hydrophilic aluminum-rich zeolite with a pore size in the range of 0.3 to 0.5 nm, 1 to 99% by weight of a disperse oil phase, 0.1 to 50% by weight of a non-ionic surface-active agent, 0.1 to 40% by weight of an emollient, 0.1 to 20% by weight of a thickener, and up to 100% by weight cosmetic carrier substances, auxiliary substances, active substances and mixtures thereof, with the provisio that no polyvalent alcohols and polar solvents are contained. The products have an enhanced water absorption, cleansing effect and a silk-like feeling.

Priority: DE20031002096 Applic. Date: 2003-01-16; WO2004EP00317 Applic. Date: 2004-01-16

Inventor: HWANG DONNA H [US]; CERNASOV DOMNICA [US]; MACCHIO RALPH [US]


Application No.: US20060068032A1  Published: 30/Mar/2006

Title: Compositions and methods for treating angiogenesis-related diseases, wounds and cosmetic use of components of Angelica sinensis, and methods of preparation thereof

Applicant/Assignee: SUNNY BIODISCOVERY, INC

Application No.: 10/948590   Filing Date: 24/Sep/2004

Abstract:Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from Angelica sinensis, or a fraction or a lyophilizate thereof, or one or more active component contained in said extract.

Priority:

Inventor: ZHAO HUI [US]; BOJANOWSKI KRZYSZTOF [US]; ARIA FARIBA [US]; MORTEZAEI REZA [US]


Application No.: US20060069051A1  Published: 30/Mar/2006

Title: AChE antisense oligonucleotide as an anti-inflammatory agent

Applicant/Assignee:

Application No.: 11/187719   Filing Date: 21/Jul/2005

Abstract:Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

Priority: IL20030158600 Applic. Date: 2003-10-26; WO2004IL00978 Applic. Date: 2004-10-26

Inventor: SOREQ HERMONA [IL]; DORI AMIR [IL]; WIRGUIN ITZHAK [IL]; IFERGANE GAL [IL]; YIRMIYA RAZ [IL]


Application No.: US20060069057A1  Published: 30/Mar/2006

Title: Medicaments containing xenogeneic oligo- and/or polyribonucleotides

Applicant/Assignee:

Application No.: 11/250067   Filing Date: 13/Oct/2005

Abstract:The invention relates to medicaments that contain xenogenic oligo- or/and polyribonucleotides as the effective component. The invention further relates to the use of said xenogenic oligo- or/and polyribonucleotides for treating herpesviridae infections and skin tumors.

Priority: DE19991040748 Applic. Date: 1999-08-27; US2002-049216 Applic. Date: 2002-04-18; WO2000EP08279 Applic. Date: 2000-08-24

Inventor: SEINFELD HUGO [DE]


Application No.: US20060069068A1  Published: 30/Mar/2006

Title: Methods and compositions for the treatment of diseases characterized by pathological calcification

Applicant/Assignee: NANOBAC PHARMACEUTICALS, INC

Application No.: 11/102798   Filing Date: 11/Apr/2005

Abstract:Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate-crystal nucleation and crystal growth, and/or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification-induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

Priority: US2004-891483 Applic. Date: 2004-07-15

Inventor: KAJANDER E O [US]; AHO K M [FI]; CIFTCIOGLU N [US]; MILLICAN B [US]


Application No.: US20060069069A1  Published: 30/Mar/2006

Title: Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate compounds and their pharmaceutical uses

Applicant/Assignee: NANOBAC PHARMACEUTICALS, INC

Application No.: 11/180921   Filing Date: 14/Jul/2005

Abstract:A composition is provided which contains calcium chelators, bisphosphonates, and/or citrate compounds and which may be used for treating and or reducing pathological calcifications, heavy metal poisoning, the growth of Nanobacterium Calcifying Nano-Particles and calcification-induced diseases in humans and animals. The method includes administering a therapeutic composition of calcium chelators, bisphosphonates, and/or citrate compounds which effectively inhibit or treat the development of calcifications in vivo. Typically, the administered composition includes about 0.1-10:1 parts by weight of calcium chelators, bisphosphonates, and/or citrate compounds.

Priority: US20040587869P Applic. Date: 2004-07-15

Inventor: KAJANDER E O [FI]; AHO K M [FI]; CIFTCIOGLU NEVA [US]; MILLICAN B [US]


Application No.: US20060069131A1  Published: 30/Mar/2006

Title: Novel complexes of fatty acid esters of polyhydroxyalkanes and pyridine carboxy derivatives

Applicant/Assignee: ASTION DERMATOLOGY A/S

Application No.: 10/517592   Filing Date: 15/Aug/2005

Abstract:The present invention relates to novel combinations of fatty acid derivatives and pyridine carboxy derivatives, including fatty acid esters with glycerol and 3-carboxy pyridine derivatives such as niacinamide. Such combinations have surprisingly shown antiviral and anti-microbial activity and the use for the treatment of inflammatory conditions and infections is disclosed herein.

Priority: DK20020000951 Applic. Date: 2002-06-20; US20020389879P Applic. Date: 2002-06-20; WO2003DK00423 Applic. Date: 2003-06-20

Inventor: WEIDNER MORTEN S [DK]


Application No.: US20060070189A1  Published: 06/Apr/2006

Title: Textile treatment agent

Applicant/Assignee:

Application No.: 11/230199   Filing Date: 19/Sep/2005

Abstract:A textile aftertreatment composition comprising (a) a skin-protecting oil and (b) urea and/or urea derivative

lactic acid and/or a lactic salt

citric acid and/or a citric acid salt wherein the composition is in the form of an emulsion. The composition is conducive directly or indirectly to the health of the skin and can be used as a supplement to the classical textile treatment compositions such as laundry detergents or fabric softeners.

Priority: DE20031011852 Applic. Date: 2003-03-17; WO2004EP02232 Applic. Date: 2004-03-05

Inventor: RAEHSE WILFRIED [DE]; RUFFER ULRIKE [DE]


Application No.: US20060073110A1  Published: 06/Apr/2006

Title: High DS cationic polygalactomannan for skincare products

Applicant/Assignee:

Application No.: 11/223525   Filing Date: 09/Sep/2005

Abstract:A skin care composition is provided with a) from about 1 to about 90 wt % of a surfactant, b) at least about 0.05 wt % of a cationic polymer wherein the cationic polymer has a mean average molecular weight (Mw) from about 2,000 to about 10,000,000 Dalton, and the cationic polymer has a cationic degree of substitution (DS) greater than 0.25 to about 3.0, and c) at least one skin care active ingredient, wherein the skin care composition provides at least one of the functions of cleansing, protection, moisturizing, firming, conditioning, occlusive barrier, emolliency, depositing, and anti-wrinkling to the skin.

Priority: US20040613007P Applic. Date: 2004-09-24

Inventor: MODI JASHAWANT J [US]


Application No.: US20060073182A1  Published: 06/Apr/2006

Title: Conveniently implantable sustained release drug compositions

Applicant/Assignee:

Application No.: 11/236426   Filing Date: 27/Sep/2005

Abstract:This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.

Priority: US20040614484P Applic. Date: 2004-10-01; US20050709665P Applic. Date: 2005-08-19

Inventor: WONG VERNON G [US]; WOOD LOUIS L [US]


Application No.: US20060073219A1  Published: 06/Apr/2006

Title: Penetrating carrier, anti-fungal composition using the same and method for treatment of dermatophytes

Applicant/Assignee:

Application No.: 10/956073   Filing Date: 04/Oct/2004

Abstract:A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifingal composition a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of eucalyptus globulus, peppermint, cedarwood, and Manuka

along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

Priority:

Inventor: SELNER MARC [US]


Application No.: US20060074051A1  Published: 06/Apr/2006

Title: Therapeutic stem cell growth factor composition, anti-inflammatory composition, and uses thereof

Applicant/Assignee: IMMUNOPATH PROFILE, INC

Application No.: 11/212530   Filing Date: 26/Aug/2005

Abstract:The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid

wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising a mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein

and at least one essential lipid.

Priority: US2000-639859 Applic. Date: 2000-08-16; US19990149338P Applic. Date: 1999-08-17

Inventor: GIRSH LEONARD S [US]


Application No.: US20060074097A1  Published: 06/Apr/2006

Title: Regulation of mammalian keratinous tissue using hexamidine compositions

Applicant/Assignee:

Application No.: 11/246317   Filing Date: 07/Oct/2005

Abstract:A method of facilitating the cosmetic delivery of a hexamidine compound to keratinous tissue via a composition including the hexamidine compound, including the step of incorporating a thickening agent that is not negatively-charged into the composition.

Priority: US2004-780267 Applic. Date: 2004-02-17; US2003-379252 Applic. Date: 2003-03-04

Inventor: BISSETT DONALD L [US]; CLEAR ROSE M [US]; ROBINSON LARRY R [US]


Application No.: US20060078518A1  Published: 13/Apr/2006

Title: Cosmetic compositions containing fluorescent colorants for natural skin appearance

Applicant/Assignee:

Application No.: 11/205570   Filing Date: 17/Aug/2005

Abstract:Cosmetic or personal care compositions which comprise at least one fluorescent colorant other than white and at least one non-fluorescent colorant, are useful in preparing colored cosmetic or personal care preparations providing an enhanced skin appearance.

Priority: US20040603591P Applic. Date: 2004-08-23

Inventor: ELDER STEWART T [US]; MORTON COLIN J H [CH]; ANDRIANOV CHRISTINA L [US]


Application No.: US20060078568A1  Published: 13/Apr/2006

Title: Use of the residues from wine production

Applicant/Assignee:

Application No.: 11/229295   Filing Date: 16/Sep/2005

Abstract:A cosmetic or pharmaceutical preparation comprising a winemaking residue is comprised of from about 1 to about 10% by weight of polyphenols and from about 25 to about 50% by weight of proteins, based on the dry residue weight. The press residues obtained in the flocculation of the fermented grape juice contain synergistic mixtures of polyphenols and proteins from the yeasts and increase the efficacy of the cosmetic or pharmaceutical preparations into which they are added for countering the effects of skin aging and damage to fibroblasts and kerotinocytes caused by UV-A and UV-B radiation.

Priority: FR19990016868 Applic. Date: 1999-12-22; US2002-399593 Applic. Date: 2002-06-21; WO2000EP12650 Applic. Date: 2000-12-13

Inventor: PAULY GILLES [FR]; HENRY FLORENCE [FR]


Application No.: US20060078577A1  Published: 13/Apr/2006

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 10/960516   Filing Date: 08/Oct/2004

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority:

Inventor: DECHOW FREDERICK J [US]


Application No.: US20060078579A1  Published: 13/Apr/2006

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/066485   Filing Date: 28/Feb/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]


Application No.: US20060078580A1  Published: 13/Apr/2006

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/150254   Filing Date: 13/Jun/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2005-066485 Applic. Date: 2005-02-28; US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]


Application No.: US20060078600A1  Published: 13/Apr/2006

Title: Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 10/544565   Filing Date: 05/Aug/2005

Abstract:The invention relates to a transdermal therapeutic system (TTS) comprising at least one pharmacological active substance, which is suitable for heating up to a temperature above skin temperature, thereby promoting the permeation rate of the active substance. The transdermal therapeutic system comprises at least one layer containing the active substance and one peelable backing layer, and is characterize in that the layer containing the active substance mainly consists of a polysiloxane in which the active substance is partially dissolved.

Priority: DE20031004989 Applic. Date: 2003-02-07; DE200410003224 Applic. Date: 2004-01-22; WO2004EP00944 Applic. Date: 2004-02-03

Inventor: MULLER WALTER [DE]


Application No.: US20060078943A1  Published: 13/Apr/2006

Title: Method for obtaining anti-idiotype antibodies

Applicant/Assignee: OMRIX BIOPHARMACEUTICALS INC

Application No.: 10/515499   Filing Date: 06/Sep/2005

Abstract:A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease

(b) binding the autoantibodies to a solid phase to form an affinity matrix

(c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components

(d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix

(e) providing a molecular library comprising a plurality of molecule members

and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.

Priority: US20020383136P Applic. Date: 2002-05-28; WO2003IL00424 Applic. Date: 2003-05-22

Inventor: NUR ISRAEL [IL]; SHOENFELD YEHUDA [IL]


Application No.: US20060079419A1  Published: 13/Apr/2006

Title: Depositable solids

Applicant/Assignee:

Application No.: 11/198364   Filing Date: 05/Aug/2005

Abstract:A stable, rinsable multi-phase personal care composition is described comprising at least two visually distinct phases. At least one visually distinct phase comprises from about 1% to about 99% of a depositable solid by weight of the composition

and wherein said stable multi-phase personal care composition provides at least about 0.2% Depositable Solids.

Priority: US20040617392P Applic. Date: 2004-10-08; US20040628036P Applic. Date: 2004-11-15; US20050680116P Applic. Date: 2005-05-12

Inventor: WAGNER JULIE ANN [US]; WEI KARL SHIQING [US]; SMITH EDWARD DEWEY III [US]; MIDHA SANJEEV [US]; HEINRICH JAMES MERLE [US]


Application No.: US20060079422A1  Published: 13/Apr/2006

Title: Personal care composition containing a cleansing phase and a benefit phase

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/227379   Filing Date: 15/Sep/2005

Abstract:Personal care compositions comprising a cleansing phase and a benefit phase. These products are intended to provide a multi-phase personal care composition that is packaged in physical contact while remaining stable and providing improved in-use and after-use hair and skin benefits.

Priority: US20040617392P Applic. Date: 2004-10-08

Inventor: MIDHA SANJEEV [US]; WELLS ROBERT L [US]; COMSTOCK BRYAN G [US]; HEINRICH JAMES M [US]; NIEBAUER MICHAEL F [US]


Application No.: US20060079696A1  Published: 13/Apr/2006

Title: Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

Applicant/Assignee: GENFIT

Application No.: 11/235707   Filing Date: 27/Sep/2005

Abstract:This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.

Priority: FR20040010192 Applic. Date: 2004-09-27

Inventor: MASSON CHRISTOPHE [FR]; CAUMONT-BERTRAND KARINE [FR]


Application No.: US20060083698A1  Published: 20/Apr/2006

Title: Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249398   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one oil containing at least one amide structural unit and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052367 Applic. Date: 2004-10-19; US20040623034P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]


Application No.: US20060083699A1  Published: 20/Apr/2006

Title: Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249521   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, notably at least one 4-hydroxybenzylidenemalonate compound, 4-hydroxycinnamate compound, fluorene compound, piperidinol salt, or mixture thereof, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052368 Applic. Date: 2004-10-19; US20040623580P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]


Application No.: US20060083738A1  Published: 20/Apr/2006

Title: Treatment of cancer by the use of anti fas antibody

Applicant/Assignee: FUSION ANTIBODIES LIMITED

Application No.: 10/514604   Filing Date: 02/Dec/2005

Abstract:The present invention provides a method of killing cancer cells and method of treatment of cancer comprising administration of a therapeutically effective amount of a) a specific binding member which binds to a cell death receptor or a nucleic acid encoding said binding member and (b) a chemotherapeutic agent. The binding member pereferably binds to a Fas receptor. Also described are medicaments for use in treating cancer.

Priority: GB20020011377 Applic. Date: 2002-05-17; GB20020014885 Applic. Date: 2002-06-27; WO2003GB02109 Applic. Date: 2003-05-16

Inventor: JOHNSTON PATRICK G [GB]; LONGLEY DANIEL [GB]


Application No.: US20060083776A1  Published: 20/Apr/2006

Title: Preparations for topical application and methods of delivering an active agent to a substrate

Applicant/Assignee:

Application No.: 11/248017   Filing Date: 11/Oct/2005

Abstract:A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate. Multi-layer dressings and methods particularly suited for management of wound exudate and effective debridement of wound eschar.

Priority: WO2004US35686 Applic. Date: 2004-10-27; US20030514709P Applic. Date: 2003-10-27

Inventor: BOTT RICHARD R [US]; BRANDSTADT KURT F [US]; KOLLAR CSILLA [US]; LANE THOMAS H [US]; LILES DONALD T [US]; SALDJENO MAE [US]; THOMAS XAVIER J [FR]; MURPHY KEVIN P [US]; SCHALAU GERALD K II [US]


Application No.: US20060084066A1  Published: 20/Apr/2006

Title: Surrogate markers of neuropathic pain

Applicant/Assignee:

Application No.: 10/784004   Filing Date: 20/Feb/2004

Abstract:The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.

Priority:

Inventor: SAH DINAH W Y [US]; CATE RICHARD [US]; EHRENFELS CHRISTIAN W [US]; SZAK SUZANNE [US]; BANDARU RAJASEKHAR [US]


Application No.: US20060084123A1  Published: 20/Apr/2006

Title: MN and hypoxia

Applicant/Assignee:

Application No.: 11/166997   Filing Date: 24/Jun/2005

Abstract:The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

Priority: US20050649661P Applic. Date: 2005-02-03; US20040598941P Applic. Date: 2004-08-05; US20010341036P Applic. Date: 2001-12-13; US2002-319003 Applic. Date: 2002-12-13

Inventor: HARRIS ADRIAN L [GB]; RATCLIFFE PETER J [GB]; VORDERMARK DIRK [DE]


Application No.: US20060084589A1  Published: 20/Apr/2006

Title: Solubilizing systems for flavors and fragrances

Applicant/Assignee:

Application No.: 11/255032   Filing Date: 19/Oct/2005

Abstract:The present invention provides compositions and clear oil-in-water microemulsion containing up to 80% w/w of an oil, a surfactant system, a w/w oil/surfactant system ratio between 1 and 3, and a solubilizing-aid ingredient which is not a surfactant neither a VOC compound, the latter being present in an amount sufficient to ensure that the ratio oil/(surfactant +solubilizing aid) is comprised between 0.1 and 5. The present invention concerns also the articles and products associated the compositions and microemulsions, and the methods to manufacture them.

Priority: US20040620557P Applic. Date: 2004-10-20

Inventor: VLAD FLORIN J [US]; MOUNIER REMY [FR]; WONG KENNETH [CH]; DAUGERON AUDE [FR]; HERD THOMAS [US]


Application No.: US20060084602A1  Published: 20/Apr/2006

Title: Platelet-derived growth factor compositions and methods of use thereof

Applicant/Assignee: BIOMIMETIC THERAPEUTICS, INC

Application No.: 11/159533   Filing Date: 23/Jun/2005

Abstract:A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

Priority: US2004-965319 Applic. Date: 2004-10-14

Inventor: LYNCH SAMUEL E [US]


Application No.: US20060084604A1  Published: 20/Apr/2006

Title: Transepithelial delivery of peptides with incretin hormone activities

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 11/219145   Filing Date: 02/Sep/2005

Abstract:Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.

Priority: US20040620001P Applic. Date: 2004-10-19

Inventor: KITAURA CHIEKO [JP]; MINOMI KENJIRO [JP]; OKUBO KATSUYUKI [JP]; OKADA KEISAKU [JP]; KAGEHISA NATSUKO [JP]; KAMIYAMA MASASHI [JP]; HOU ZHENG [US]; LIU JIAN [US]; SONG YUCHENG [US]; YU LEI [US]


Application No.: US20060084684A1  Published: 20/Apr/2006

Title: Topically applicable pharmaceutical preparation

Applicant/Assignee: ALTANA PHARMA AG

Application No.: 10/515698   Filing Date: 11/Aug/2005

Abstract:A topical pharmaceutical preparation for administering a slightly soluble PDE 4 inhibitor that has a surprisingly good systemic bioavailability is described.

Priority: EP20020011830 Applic. Date: 2002-05-28; DE20021023828 Applic. Date: 2002-05-28; DE20031011613 Applic. Date: 2003-03-14; WO2003EP05524 Applic. Date: 2003-05-27

Inventor: BOLLE CHRISTINA [DE]; LINDER RUDOLF [DE]


Application No.: US20060084799A1  Published: 20/Apr/2006

Title: Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use

Applicant/Assignee:

Application No.: 10/948571   Filing Date: 24/Sep/2004

Abstract:The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.

Priority: US20030505144P Applic. Date: 2003-09-24; US20040548191P Applic. Date: 2004-03-01; US20040589826P Applic. Date: 2004-07-22; US20040589788P Applic. Date: 2004-07-22

Inventor: WILLIAMS LEWIS T [US]; CHU KETING [US]; LEE ERNESTINE [US]; HESTIR KEVIN [US]; WONG JUSTIN [US]; DOBERSTEIN STEPHEN K [US]


Application No.: US20060088471A1  Published: 27/Apr/2006

Title: Compounds for enzyme inhibition

Applicant/Assignee: PROTEOLIX, INC

Application No.: 11/254541   Filing Date: 19/Oct/2005

Abstract:Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and/or dosing purposes.

Priority: US20040620573P Applic. Date: 2004-10-20; US20050674834P Applic. Date: 2005-04-26

Inventor: BENNETT MARK K [US]; BUCHHOLZ TONIA J [US]; DEMO SUSAN D [US]; LAIDIG GUY J [US]; LEWIS EVAN R [US]; SMYTH MARK S [US]


Application No.: US20060088489A1  Published: 27/Apr/2006

Title: Sustained release of active molecules from polymers topically applied to skin or hair

Applicant/Assignee:

Application No.: 11/259458   Filing Date: 26/Oct/2005

Abstract:The invention relates to a polymer for topical delivery of biologically active ingredients, the polymer comprising at least one moiety: U-B-A in which U represents a physiologically acceptable unit of an oligomer or polymer, A represents a biologically active component, and B represents one or more bond(s) linking A to U, which bond is capable of being disrupted by a biological, physical or chemical process occurring in or on skin.

Priority: US20040622583P Applic. Date: 2004-10-27

Inventor: GIACOMONI PAOLO [US]; GROSS RICHARD [US]; LACZYNSKI STEPHEN [US]


Application No.: US20060088515A1  Published: 27/Apr/2006

Title: Methods and devices for sustained in-vivo release of an active agent

Applicant/Assignee:

Application No.: 11/238144   Filing Date: 27/Sep/2005

Abstract:The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.

Priority: US20040623150P Applic. Date: 2004-10-27; US2005-238104 Applic. Date: 2005-09-27

Inventor: HIGUCHI JOHN [US]; LI S K [US]; HIGUCHI WILLIAM I [US]; HASTINGS MATTHEW S [US]


Application No.: US20060088561A1  Published: 27/Apr/2006

Title: Pharmaceutical composition for topical application

Applicant/Assignee: FOAMIX LTD

Application No.: 11/294318   Filing Date: 05/Dec/2005

Abstract:A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.

Priority: US2003-392071 Applic. Date: 2003-03-19; US2000-653267 Applic. Date: 2000-08-31; US20000216162P Applic. Date: 2000-07-03; WO2001IL00025 Applic. Date: 2001-01-10; IL20000133968 Applic. Date: 2000-01-10; IL20000133969 Applic. Date: 2000-01-10; IL20000137051 Applic. Date: 2000-06-27; IL20000137052 Applic. Date: 2000-06-27; IL20020150644 Applic. Date: 2002-07-17; US2000-526509 Applic. Date: 2000-03-16

Inventor: EINI MEIR [IL]; TAMARKIN DOV [IL]


Application No.: US20060088580A1  Published: 27/Apr/2006

Title: Hormone-containing transdermal therapeutic system with an active substance reservoir based on vinylacetate-vinylpyrrolidone copolymer with improved cohesion

Applicant/Assignee:

Application No.: 10/507628   Filing Date: 07/Oct/2005

Abstract:A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.

Priority: DE20021011832 Applic. Date: 2002-03-16; WO2003EP02521 Applic. Date: 2003-03-12

Inventor: MECONI REINHOLD [DE]; KLEIN ROBERT-PETER [DE]; KLEIN URSULA H [DE]; SEIBERTZ FRANK [DE]; BECKER FRANZ-JOSEF [DE]; COTTE URSULA [DE]


Application No.: US20060088612A1  Published: 27/Apr/2006

Title: Composition for treatment of topical infection and methods of making and using same

Applicant/Assignee:

Application No.: 11/218872   Filing Date: 02/Sep/2005

Abstract:Compositions and methods for the prevention and treatment of topical infections using essential oil or extract from Minthostachys mollis (Peperina) or other herbs of the family Lamiaceae, or any combination of its individual chemical components and an acceptable carrier are disclosed.

Priority: US20040606679P Applic. Date: 2004-09-02

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]


Application No.: US20060088852A1  Published: 27/Apr/2006

Title: Method for determining the homeostasis of hairy skin

Applicant/Assignee:

Application No.: 11/158209   Filing Date: 20/Jun/2005

Abstract:The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating hairy skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating hairy skin and to a method for producing a cosmetic or pharmaceutical preparation for treating hairy skin.

Priority: DE20021060931 Applic. Date: 2002-12-20; WO2003EP14070 Applic. Date: 2003-12-11

Inventor: PETERSOHN DIRK [DE]; SCHLOTMANN KORDULA [DE]; GASSENMEIER THOMAS [DE]; HOLTKOETTER OLAF [DE]; CONRADT MARCUS [DE]; HOFMANN KAY [DE]


Application No.: US20060089342A1  Published: 27/Apr/2006

Title: Topical anti-microbial compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY ARCH CHEMICALS, INC

Application No.: 11/299195   Filing Date: 08/Dec/2005

Abstract:Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Priority: US2000-599624 Applic. Date: 2000-06-22

Inventor: GAVIN DAVID F [US]; MARCHETTA ANTHONY R [US]; NELSON JOHN D JR [US]; POLSON GEORGE [US]; SCHWARTZ JAMES R [US]; TURLEY PATRICIA A [US]


Application No.: US20060089389A1  Published: 27/Apr/2006

Title: Combination

Applicant/Assignee:

Application No.: 11/295928   Filing Date: 07/Dec/2005

Abstract:The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof

(ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof

and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

Priority: US2003-362340 Applic. Date: 2003-06-16; WO2001EP09587 Applic. Date: 2001-08-20; US20000327553P Applic. Date: 2000-08-22

Inventor: ALLISON MALCOLM [CH]; GATLIN MARJORIE R [US]


Application No.: US20060089406A1  Published: 27/Apr/2006

Title: Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases

Applicant/Assignee:

Application No.: 10/528308   Filing Date: 12/Sep/2005

Abstract:The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at least one inhibitor of fatty acid oxidation for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of a chronic and/or an atopic skin disease.

Priority: US20020411962P Applic. Date: 2002-09-19; WO2003EP10397 Applic. Date: 2003-09-18

Inventor: NIELAND JOHN [DE]; GANDER-MEISTERNST IRENE [DE]; ROHRBACH MARTIN [DE]; NAVE BARBARA [DE]


Application No.: US20060090271A1  Published: 04/May/2006

Title: Processes for modifying textiles using ionic liquids

Applicant/Assignee:

Application No.: 11/263391   Filing Date: 31/Oct/2005

Abstract:Processes for modifying a textile to improve its performance which comprise the steps of a) contacting a textile comprising fibers with a treating composition comprising an ionic liquid under conditions sufficient to modify at least surfaces of the fibers, thereby provide a performance improvement to treated textile

b) optionally, contacting a textile comprising fibers with a composition comprising a benefit agent

and c) at least partially removing the treating composition from the textile. In specific embodiments, the surface modification comprises a partial dissolution of at least one outer layer of the fibers and/or crystal structure change in at least surfaces of the fibers. The surface modification can impart improvements to the textile or allow embedding or attachment of a benefit agent in the fibers.

Priority: US20040624053P Applic. Date: 2004-11-01

Inventor: PRICE KENNETH N [US]; WANG JIPING [US]; WASHINGTON NODIE M [US]; HECHT STACIE E [US]; MIRACLE GREGORY S [US]; SCHEIBEL JEFFREY J [US]


Application No.: US20060090777A1  Published: 04/May/2006

Title: Multiphase cleaning compositions having ionic liquid phase

Applicant/Assignee:

Application No.: 11/263392   Filing Date: 31/Oct/2005

Abstract:A multiphase cleaning composition comprises a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase. The first phase may comprise, for example, an aqueous phase or a silicone solvent system. Methods of cleaning a soiled surface comprise contacting a soiled surface with a multiphase wash liquor including a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase, and removing soils from the surface.

Priority: US20040624127P Applic. Date: 2004-11-01

Inventor: HECHT STACIE E [US]; PRICE KENNETH N [US]; BERGER PATRICIA S [US]; FOLEY PETER R [US]; HUTTON HOWARD D III [US]; SHOWELL MICHAEL S [US]; GARDNER ROBB R [US]; NIEHOFF RAYMOND L [US]; SEDDON KENNETH R [GB]; GUNARATNE HARAMBAGE QUINTAS N [GB]; EARLE MARTYN [GB]


Application No.: US20060093553A1  Published: 04/May/2006

Title: Cd26-based therapies for cancers and immune disease

Applicant/Assignee:

Application No.: 10/514738   Filing Date: 19/Oct/2005

Abstract:Therapeutic methods comprising administering a composition comprising CD26 thereof in conjunction with chemotherapeutic agents or radiotherapeutic agents for the prevention and treatment of cancers are provided. Also provided are methods for potentiating immune responses comprising administering a composition comprising CD26.

Priority: US20020381606P Applic. Date: 2002-05-17; WO2003US15499 Applic. Date: 2003-05-15

Inventor: DANG NAM H [US]; MORIMOTO CHIKAO [JP]


Application No.: US20060093588A1  Published: 04/May/2006

Title: Device for bio-affinity material

Applicant/Assignee: GLYCOREX TRANSPLANTATION AB

Application No.: 11/304364   Filing Date: 15/Dec/2005

Abstract:Bio-affinity material containing at least one biologically active saccharide which is covalently bound via at least one spacer to a cross-linked matrix and that the material is autoclaved. Apparatus for contacting body fluids with the bio-affinity material is disclosed.

Priority: US2002-114314 Applic. Date: 2002-04-03; US1996-091486 Applic. Date: 1996-12-23; US2000-722241 Applic. Date: 2000-11-27; WO2001SE00241 Applic. Date: 2001-02-07

Inventor: NILSSON KURT G L [SE]


Application No.: US20060093633A1  Published: 04/May/2006

Title: Cosmetic and/or dermatological preparation comprising 2,3-dibenzylbutyrolactones

Applicant/Assignee:

Application No.: 10/515000   Filing Date: 26/Sep/2005

Abstract:Cosmetic and/or dermatological preparation containing one or more 2,3-dibenzylbutyrolactone derivatives and/or their glycosides besides optionally additional cosmetic and/or dermatological active ingredients, auxiliary agents, and additives.

Priority: DE20021023486 Applic. Date: 2002-05-27; WO2003EP05347 Applic. Date: 2003-05-22

Inventor: STAB FRANZ [DE]; WOLBER RAINER [DE]; BLATT THOMAS [DE]; KOLBE LUDGER [DE]; MUNDT CLAUDIA [DE]; GALLIANT STEFAN [DE]; VENZKE KIRSTEN [DE]; DIECK KAREN T [DE]; BREITENBACH UTE [DE]


Application No.: US20060093634A1  Published: 04/May/2006

Title: Personal care compositions and concentrates for making the same

Applicant/Assignee: LONZA INC

Application No.: 11/112479   Filing Date: 22/Apr/2005

Abstract:The present invention relates to color stable personal care compositions that provide anti-oxidiation, moisturization, and/or prevent biodegradation in personal care formulations. These compositions contain erythorbic acid or a salt thereof, caffeic acid or a salt thereof, delta-gluconolactone, or a mixture thereof. The present invention further relates to methods of moisturizing skin with erythorbic acid or a salt thereof, or delta-gluconolactone. The present invention also relates to concentrates of active ingredients preloaded with a sufficient amount of an anti-oxidation, moisturizing and/or biodegradation prevention agent so that when it is diluted for use, the final formulation includes an anti-oxidation, moisturizing and/or biodegradation prevention effective amount of the anti-oxidation, moisturizing, and/or biodegradation prevention agent.

Priority: US20040565003P Applic. Date: 2004-04-23

Inventor: LUTZ PATRICK J [US]; WINTERS KRISTY A [US]; DUNN KELLY A [US]; GUTH JACOB [US]


Application No.: US20060093659A1  Published: 04/May/2006

Title: Hydroxide-releasing agents as skin permeation enhancers

Applicant/Assignee:

Application No.: 11/303614   Filing Date: 16/Dec/2005

Abstract:A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

Priority: US2003-371352 Applic. Date: 2003-02-19; US2000-738410 Applic. Date: 2000-12-14; US2000-569889 Applic. Date: 2000-05-11; US1999-465098 Applic. Date: 1999-12-16

Inventor: LUO ERIC C [US]; JACOBSON ERIC C [US]; HSU TSUNG-MIN [US]


Application No.: US20060093670A1  Published: 04/May/2006

Title: Sustained-release composition process for producing the same and preparation thereof

Applicant/Assignee:

Application No.: 10/516122   Filing Date: 22/Dec/2005

Abstract:The present invention provides a sustained-release composition by which a sustained-release effect can be obtained for a long time when injecting microparticles of the composition in an amount that can be subcutaneously or intramuscularly injected to a human with ease and without pain. The composition comprises porous hydroxyapatite microparticles having pores embolized by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a mucopolysaccharide, and adding a divalent metal ion. Alternatively, the composition comprises porous hydroxyapatite microparticles having pores embolized in the outer layer by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a water-soluble calcium salt one after another or at one time, and then adding sodium carbonate, sodium hydrogen carbonate, or an aqueous carbonate ion solution.

Priority: JP20020179788 Applic. Date: 2002-06-20; JP20020374173 Applic. Date: 2002-12-25; WO2003JP07251 Applic. Date: 2003-06-09

Inventor: MIZUSHIMA YUTAKA [JP]; TAKAGI YUKIE [JP]; HAGI TOMOMI [JP]; IKOMA TOSHIYUKI [JP]


Application No.: US20060093689A1  Published: 04/May/2006

Title: Skin cosmetics

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 11/302363   Filing Date: 14/Dec/2005

Abstract:Skin cosmetics which are excellent in moistness and persistency of moisture-keeping effect, show light sense of touch when used and have excellent periodical stability. In addition, there are provided skin cosmetics which do not cause stickiness after their use, are excellent in rough skin improving and preventing effects, wrinkle preventing and improving effects, dinginess improving effect and the like, and also have an effect in providing the skin with smoothness and liveliness. Also, in the case of skin cleansing compositions, they exert such effects that they can provide the skin with liveliness and moistness after washing and can effectively remove fishy and ammonia smells or the like filthy smell adhered to the hand, the skin and the like. A skin cosmetic characterized in that it contains (A) at least one substance selected from seed extracts and seed hull extracts of a plant belonging to the genus Carya of the family Juglandaceae in an amount of from 0.00005 to 2% by weight as solid matter, and (B) an additive agent.

Priority: JP20020348360 Applic. Date: 2002-11-29; JP20020370231 Applic. Date: 2002-12-20; JP20020370238 Applic. Date: 2002-12-20; US2003-724354 Applic. Date: 2003-12-01

Inventor: KAWADA IZUMI [JP]; ISHIDA MISAKI [JP]


Application No.: US20060094617A1  Published: 04/May/2006

Title: Benefit agent delivery system comprising ionic liquid

Applicant/Assignee:

Application No.: 11/263389   Filing Date: 31/Oct/2005

Abstract:A benefit agent delivery system comprises a benefit agent, wherein the benefit agent is protected or stabilized by an ionic liquid and wherein the benefit agent is releasable from the system to provide the benefit. For example, the ionic liquid may be physically associated with the benefit agent, such as by coating, encapsulation, or co-crystallization, or may be chemically associated with the benefit agent, such as by chemical reaction. The benefit agent delivery system may be in the form of a concentrate, in a product formulation, or on or associated with a substrate or package. Detergent compositions may include the benefit agent delivery system. Methods for cleaning a soiled substrate comprise contacting a soiled substrate with such a composition, and removing soil from the substrate.

Priority: US20040624051P Applic. Date: 2004-11-01

Inventor: PRICE KENNETH N [US]; HECHT STACIE E [US]; JORDAN GLENN T IV [US]; KENNEALLY COREY J [US]; AOUAD YOUSEF G [US]; SHOWELL MICHAEL S [US]; MIRACLE GREGORY S [US]


Application No.: US20060094628A1  Published: 04/May/2006

Title: Multi-phase personal cleansing compositions comprising a lathering cleansing phase and a non-lathering structured aqueous phase

Applicant/Assignee:

Application No.: 11/263749   Filing Date: 01/Nov/2005

Abstract:The present invention relates to multi-phase personal cleansing compositions containing a lathering cleansing phase and a separate non-lathering structured aqueous phase wherein the two phases are packaged in physical contact while remaining stable over time.

Priority: US2004-001796 Applic. Date: 2004-12-02; US20030532798P Applic. Date: 2003-12-24; US20040576199P Applic. Date: 2004-06-02

Inventor: WEI KARL S [US]; SMITH EDWARD D III [US]


Application No.: US20060094635A1  Published: 04/May/2006

Title: Aqueous cleansing composition with gel flakes

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/978511   Filing Date: 01/Nov/2004

Abstract:An aqueous liquid cleansing and optional moisturizing composition is provided having a surfactant

a thickening or structuring agent, and gel flakes containing in a preferred embodiment plate-like particles. The gel flakes provide unique aesthetics to the cleansing composition. In another preferred embodiment the inventive cleansing composition includes a free skin conditioning agent having a weight average particle size in the range about 1 to about 500 microns or a clear suspending surfactant system.

Priority:

Inventor: PEREIRA DANIEL [US]


Application No.: US20060094699A1  Published: 04/May/2006

Title: Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy

Applicant/Assignee:

Application No.: 11/246814   Filing Date: 07/Oct/2005

Abstract:Combination therapy comprising the administration of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist for treating some forms of cancer, diseases and disorders having inflammation as a component, and to minimize the side effects associated with glucorticoid receptor agonist therapy.

Priority: DK20030000570 Applic. Date: 2003-04-11; DK20030000566 Applic. Date: 2003-04-11; DK20030000565 Applic. Date: 2003-04-11; DK20030000569 Applic. Date: 2003-04-11; DK20030000567 Applic. Date: 2003-04-11; DK20030000571 Applic. Date: 2003-04-11; DK20030000776 Applic. Date: 2003-05-22; DK20030000777 Applic. Date: 2003-05-22; DK20030000972 Applic. Date: 2003-06-27; DK20030000990 Applic. Date: 2003-06-30; DK20030000778 Applic. Date: 2003-05-22; DK20030000989 Applic. Date: 2003-06-30; DK20030000988 Applic. Date: 2003-06-30; DK20030000998 Applic. Date: 2003-07-02; DK20030001910 Applic. Date: 2003-12-22; DK20040000009 Applic. Date: 2004-01-06; DK20030000568 Applic. Date: 2003-04-11; WO2004DK00248 Applic. Date: 2004-04-06; US20030467284P Applic. Date: 2003-05-02; US20030467453P Applic. Date: 2003-05-02; US20030467363P Applic. Date: 2003-05-02; US20030467362P Applic. Date: 2003-05-02; US20030467443P Applic. Date: 2003-05-02; US20030475157P Applic. Date: 2003-06-02; US20030475195P Applic. Date: 2003-06-02; US20030486078P Applic. Date: 2003-07-10; US20030486098P Applic. Date: 2003-07-10; US20030486094P Applic. Date: 2003-07-10; US20030486095P Applic. Date: 2003-07-10; US20030486097P Applic. Date: 2003-07-10; US20040537099P Applic. Date: 2004-01-16

Inventor: KAMPEN GITA CAMILLA T [DK]; ANDERSEN HENRIK S [DK]


Application No.: US20060094720A1  Published: 04/May/2006

Title: NK1 antagonists

Applicant/Assignee:

Application No.: 11/300848   Filing Date: 15/Dec/2005

Abstract:Disclosed are NK1 antagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, using the compounds of formula (I).

Priority: US2003-612176 Applic. Date: 2003-07-02; US20020393708P Applic. Date: 2002-07-03

Inventor: SHIH NENG-YANG [US]; WANG STEVEN [US]; REICHARD GREGORY [US]; XIAO DONG [US]; WANG CHENG [US]


Application No.: US20060094781A1  Published: 04/May/2006

Title: Method of treating extracellular matrix

Applicant/Assignee: SYNERON MEDICAL LTD

Application No.: 10/980822   Filing Date: 04/Nov/2004

Abstract:A method for treating skin tissue or extracellular matrix in a body region. A precursor of a photosensitive compound is introduced into the body region. One or more enzymes converting the precursor to the photosensitive compound are then introduced into the body region so as to convert the precursor to the photosensitive compound in the extracellular matrix of the body region.

Priority:

Inventor: ECKHOUSE SIMON [IL]; KREINDEL MICHAEL [IL]; SHILOH JOSEPH [IL]


Application No.: US20060094988A1  Published: 04/May/2006

Title: Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy

Applicant/Assignee:

Application No.: 11/262452   Filing Date: 27/Oct/2005

Abstract:Obesity or fat deposits are treated with ultrasound. In one embodiment, a waveguide-based apparatus and method are disclosed for applying ultrasound to a treatment-subject for the purpose of providing treatment or therapy for obesity, fat-deposits, cosmetic benefit or other bodily therapy tasks. In another embodiment, a novel apparatus and method are disclosed for providing at least one such treatment or therapy using a liquid-based waveguide. In yet another embodiment, a wearable apparatus is disclosed that incorporates a waveguide of the invention. Any of the embodiments has application to hospital use, clinical use or home use, for example, and the place of use will likely be determined by which treatment mechanism is employed and at what power-level.

Priority: US20040623535P Applic. Date: 2004-10-28

Inventor: TOSAYA CAROL A [US]; BLUMENFELD LEE [US]; SLIWA JOHN W JR [US]


Application No.: US20060095103A1  Published: 04/May/2006

Title: Aesthetic thermal sculpting of skin

Applicant/Assignee: APSARA MEDICAL CORPORATION

Application No.: 11/298420   Filing Date: 09/Dec/2005

Abstract:Method, system and apparatus for carrying out a controlled heating of dermis to achieve a percentage of linear collagen shrinkage. Implants are employed which preferably are configured as a thermal barrier defining support an outwardly disposed support surface of which carries one or more heater segments. Located along heating channels at the interface between dermis and next adjacent subcutaneous tissue, the structure protects the latter from thermally induced damage while directing heat energy into the former.

Priority: US2003-733970 Applic. Date: 2003-12-11; US20050677955P Applic. Date: 2005-05-05

Inventor: EGGERS PHILIP E [US]; CAMPBELL-WHITE ANNETTE [US]; TOTH BRYANT A [US]


Application No.: US20060099159A1  Published: 11/May/2006

Title: Novel amine, amide, sulphonamide and carbamate derivatives of benzalmalonic salts and photoprotective cosmetic compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/315249   Filing Date: 23/Dec/2005

Abstract:Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least one novel amine, amide, sulphonamide or carbamate substituted benzalmalonic salt compound.

Priority: FR20030002561 Applic. Date: 2003-03-03; US2004-787759 Applic. Date: 2004-02-27; US20030483652P Applic. Date: 2003-07-01

Inventor: RICHARD HERVE [FR]; LUPPI BERNADETTE [FR]


Application No.: US20060099160A1  Published: 11/May/2006

Title: Composition intended to be applied to the skin and the integuments

Applicant/Assignee:

Application No.: 10/529872   Filing Date: 12/Oct/2005

Abstract:The present invention relates to a composition intended to be applied to the skin, the lips and/or the integuments, comprising, in a physiologically acceptable medium, at least one composite pigment comprising:-a mineral core,-at least one organic pigment at least partially covering the mineral core,and-at least one binder for fixing the organic pigment onto the mineral core.

Priority: FR20020012215 Applic. Date: 2002-10-02; US20020428723P Applic. Date: 2002-11-25; WO2003IB04306 Applic. Date: 2003-10-01

Inventor: DUMOUSSEAUX CHRISTOPHE [JP]


Application No.: US20060099167A1  Published: 11/May/2006

Title: Personal care composition containing a non-guar galactomannan polymer derivative

Applicant/Assignee:

Application No.: 11/264645   Filing Date: 01/Nov/2005

Abstract:Personal care compositions comprise (a) from about from about 5 wt. % to about 35 wt. % of a detersive surfactant

(b) at least about 0.05 wt. % of a galactomannan polymer derivative having a mannose to galactose ratio of greater than 2:1 on a monomer to monomer basis, the galactomannan polymer derivative selected from a cationic galactomannan polymer derivative and an amphoteric galactomannan polymer derivative having a net positive charge, the galactomannan polymer derivative having a molecular weight from about 1,000 to about 10,000,000 and a cationic charge density from about 0.9 meq/g to about 7 meq/g

and (c) at least about 20 wt. % of an aqueous carrier. Methods of treating hair or skin comprise applying the personal care composition as described above to the hair or skin and rinsing the hair or skin.

Priority: US20040625511P Applic. Date: 2004-11-05

Inventor: STAUDIGEL JAMES A [US]; PEFFLY MARJORIE M [US]; PLIEGO SALVADOR [US]; DECKNER GEORGE E [US]


Application No.: US20060099196A1  Published: 11/May/2006

Title: Photoprotective orally administrable composition for skin

Applicant/Assignee:

Application No.: 11/314043   Filing Date: 20/Dec/2005

Abstract:An orally administrable composition for the photoprotection of the skin which comprises a photoprotecting effective amount of i) at least one probiotic lactic acid bacterium or a culture supernatant thereof, and ii) at least one yeast, included into an orally acceptable carrier.

Priority: EP20020075701 Applic. Date: 2002-02-21; US2003-695833 Applic. Date: 2003-10-30; US2004-504906 Applic. Date: 2004-08-18; WO2003EP01686 Applic. Date: 2003-02-18

Inventor: BRETON LIONEL [FR]; BUREAU-FRANZ ISABELLE [CH]; GUENICHE AUDREY [FR]


Application No.: US20060099223A1  Published: 11/May/2006

Title: Enzymetic hydrolysate of algae and method for preparing the same

Applicant/Assignee: TAIYEN BIOTECH CO. LTD

Application No.: 11/041692   Filing Date: 24/Jan/2005

Abstract:An enzymatic hydrolysate of algae and a method for preparing the same are disclosed. After rehydrating dry algae, an insoluble pellet is digested by using a specific enzymatic reaction condition, so as to produce the soluble and bioactive enzymatic hydrolysate of algae. The enzymatic hydrolysate of algae, which comprises a mixture of polysaccharides and polypeptides, can promote a growth of skin cells cultured in vitro and be formulated in cosmetic, food or skin external agent compositions.

Priority: TW20040134535 Applic. Date: 2004-11-11

Inventor: CHEN PO-HAN [TW]; HUANG MING-HUNG [TW]


Application No.: US20060099247A1  Published: 11/May/2006

Title: Liquid, gas and/or vapor phase delivery systems

Applicant/Assignee: BYRD-WALSH, LLC

Application No.: 10/986101   Filing Date: 10/Nov/2004

Abstract:This invention relates generally to liquid, gas and/or vapor phase delivery systems and, more particularly, to delivery systems that incorporate at least one layer, film and/or capsule that produces a liquid, gas and/or vapor phase compound or compounds for use therein.

Priority:

Inventor: CANTWELL EVELYNA D [US]; CANTWELL JOHN W [US]; LYUBLINSKI EFIM Y [US]; VAKS YEFIM [US]


Application No.: US20060099273A1  Published: 11/May/2006

Title: Sterile preparations and compositions including stinging capsules and methods of producing and using same

Applicant/Assignee: NANOCYTE INC

Application No.: 10/981522   Filing Date: 05/Nov/2004

Abstract:A sterile stinging capsule preparation and methods of producing and using same are provided.

Priority: US2004-868802 Applic. Date: 2004-06-17; US2003-406202 Applic. Date: 2003-04-04; US2001-963672 Applic. Date: 2001-09-27; US20000235910P Applic. Date: 2000-09-28

Inventor: LOTAN TAMAR [IL]


Application No.: US20060099550A1  Published: 11/May/2006

Title: Device and method for delivering an oral care agent

Applicant/Assignee: RANIR/DCP CORPORATION

Application No.: 10/985709   Filing Date: 10/Nov/2004

Abstract:An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Priority:

Inventor: FAASSE ADRIAN L [US]; KLEMM STEVEN R [US]; GROENEWEG GLEN E [US]; THELEN ALAN G [US]


Application No.: US20060100141A1  Published: 11/May/2006

Title: Anti-allergic complex molecules

Applicant/Assignee: RAMOT AT TEL AVIV UNIVERSITY LTD

Application No.: 11/214588   Filing Date: 29/Aug/2005

Abstract:The present invention discloses novel anti-allergic complex molecules, and in particular, peptidic or peptidomimetic molecules, that includes a first part which is competent for cell penetration and a second part which is able to reduce or abolish mast cell degranulation, in particular to reduce or abolish allergy mediators, including histamine secretion from mast cells and protein kinase activation, wherein the first part is connected to the second part via a linker or a direct bond that creates a conformational constraint by forming a bend or turn.

Priority: IL20000140473 Applic. Date: 2000-12-21; US2003-465826 Applic. Date: 2003-06-20; WO2001IL01186 Applic. Date: 2001-12-20

Inventor: EISENBERG RONIT [IL]; RAZ TAMAR [IL]


Application No.: US20060100165A1  Published: 11/May/2006

Title: Topical application of ivermectin for the treatment of dermatological conditions/afflictions

Applicant/Assignee: GALDERMA S.A

Application No.: 11/255910   Filing Date: 24/Oct/2005

Abstract:Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.

Priority: FR20030005048 Applic. Date: 2003-04-24; WO2004EP04950 Applic. Date: 2004-04-22; US20030468994P Applic. Date: 2003-05-09

Inventor: MANETTA VINCENT [US]; WATKINS GARY R [US]


Application No.: US20060100187A1  Published: 11/May/2006

Title: Synergistic combinations of macrolide t-cell modulator or immunosuppressant and a retinoid

Applicant/Assignee:

Application No.: 10/550358   Filing Date: 23/Sep/2005

Abstract:Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.

Priority: GB20030007864 Applic. Date: 2003-04-04; WO2004EP03511 Applic. Date: 2004-04-02

Inventor: GRASSBERGER MAXIMILIAN [AT]; HIRSCH STEFAN [DE]; MAYER FRIEDRICH K [CH]; MEINGASSNER JOSEF G [AT]; PAUL CARLE [FR]; SEKKAT NABILA [CH]; STUTZ ANTON [AT]


Application No.: US20060104912A1  Published: 18/May/2006

Title: Mousse composition

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/303298   Filing Date: 16/Dec/2005

Abstract:A pharmaceutical aerosol foam composition including an effective amount of a pharmaceutically active ingredient

an occlusive agent

an aqueous solvent

and an organic cosolvent, the pharmaceutically active ingredient being insoluble in both water and the occlusive agent

the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use.

Priority: AU1998PP05831 Applic. Date: 1998-09-11; US2004-766202 Applic. Date: 2004-01-27; US2001-719662 Applic. Date: 2001-01-30; WO1999AU00735 Applic. Date: 1999-09-08

Inventor: ABRAM ALBERT Z [AU]


Application No.: US20060104924A1  Published: 18/May/2006

Title: Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249304   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one arylalkyl benzoate compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052370 Applic. Date: 2004-10-19; US20040623038P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]


Application No.: US20060104926A1  Published: 18/May/2006

Title: Whitening agent, skin preparation for external use and cosmetic

Applicant/Assignee: NICHIREI BIOSCIENCE INC NICHIREI BIOSCIENCES INC

Application No.: 10/537958   Filing Date: 22/Jul/2005

Abstract:The invention relates to a whitening agent that makes effective use of camu camu seeds, which have conventionally been discarded, and that has high safety and whitening effect useful in cosmetics and the like, as well as skin preparations for external use and cosmetics containing the whitening agent. The whitening agent of the present invention contains camu camu seed extract as an active component, and the skin preparations for external use and cosmetics of the present invention contain the whitening agent.

Priority: JP20020362507 Applic. Date: 2002-12-13; WO2003JP15656 Applic. Date: 2003-12-08

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]


Application No.: US20060104927A1  Published: 18/May/2006

Title: Compound, process for producing the same and use thereof

Applicant/Assignee: NICHIREI BIOSCIENCES INC

Application No.: 10/543801   Filing Date: 29/Jul/2005

Abstract:The compound of the present invention is a component originated from a natural material, camu camu (Myrciaria dubia), has strong antioxidative activity and stable whitening effect, and is represented by the formula (1). The antioxidant, whitening agent, skin preparation for external use, cosmetics, and food of the present invention are characterized by the inclusion of the compound represented by the formula (1).

Priority: JP20030042486 Applic. Date: 2003-02-20; WO2003JP16544 Applic. Date: 2003-12-24

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]


Application No.: US20060105000A1  Published: 18/May/2006

Title: Compositions for treating infected skin and mucous membrane comprising an anti-microbial agent and an essential oil

Applicant/Assignee: J.P.M.E.D. LTD

Application No.: 10/535961   Filing Date: 20/May/2005

Abstract:The invention provides a composition of matter for treating infected skin and mucousal membranes, said composition comprising at least one anti-microbial drug

and at least one essential oil, in combination with a substantially, alcohol-free carrier system, said carrier being selected from a liquid carrier or a semi-solid carrier, said carrier system being selected from isotonic system and a moderately hypertonic system.

Priority: IL20020152993 Applic. Date: 2002-11-21; IL20030158901 Applic. Date: 2003-11-17; WO2003IL00980 Applic. Date: 2003-11-19

Inventor: FRIEDMAN DORON I [IL]


Application No.: US20060105005A1  Published: 18/May/2006

Title: Skin care formulation containing whole egg powder

Applicant/Assignee:

Application No.: 11/328399   Filing Date: 10/Jan/2006

Abstract:A skin care formulation is provided, the formulation comprises dehydrated whole egg, at least one emollient substance and at least one humectant substance and the dehydrated whole egg is hydrated during the manufacturing process.

Priority: US2005-294838 Applic. Date: 2005-12-07; US2002-260344 Applic. Date: 2002-10-01; US2002-039793 Applic. Date: 2002-01-08

Inventor: MARENICK MICHAEL [US]; ALBRIGHT ROBERT L [US]


Application No.: US20060105028A1  Published: 18/May/2006

Title: Systems and methods for treating warts

Applicant/Assignee:

Application No.: 11/271020   Filing Date: 10/Nov/2005

Abstract:The present invention is drawn to systems and methods for treating warts. The system can comprise a wart treatment formulation comprising a substance for treating warts and a cavity patch comprising an open cavity being configured to become a closed cavity upon application and adherence to a skin surface. The closed cavity can be configured to contain the wart treatment formulation.

Priority: US20040627555P Applic. Date: 2004-11-12

Inventor: ZHANG JIE [US]; WARNER KEVIN S [US]


Application No.: US20060105030A1  Published: 18/May/2006

Title: Transdermal therapeutic system

Applicant/Assignee:

Application No.: 11/087754   Filing Date: 24/Mar/2005

Abstract:The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer. Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir

a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir

and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy.

The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the Restless Leg Syndrome and Periodic Limb Movement Disorder.

The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.

Priority: DE20001043321 Applic. Date: 2000-08-24; DE20031041317 Applic. Date: 2003-09-03; DE20001053397 Applic. Date: 2000-10-20; WO2004DE01133 Applic. Date: 2004-05-30; US2003-362248 Applic. Date: 2003-07-07; WO2001EP09824 Applic. Date: 2001-08-24; US2003-362183 Applic. Date: 2003-07-21; WO2001EP09823 Applic. Date: 2001-08-24; US2003-362182 Applic. Date: 2003-07-03; WO2001EP09826 Applic. Date: 2001-08-24

Inventor: WINDT-HANKE FRED [DE]; GUNTHER CLEMENS [DE]; HOROWSKI REINHARD [DE]; TACK JOHANNES [DE]; ENGFER ADALBERT [DE]; BOSTEDT KATALIN T [DE]; SCHENK DIRK [DE]


Application No.: US20060106000A1  Published: 18/May/2006

Title: Use of inositol-tripyrophosphate in treating tumors and diseases

Applicant/Assignee:

Application No.: 11/175979   Filing Date: 06/Jul/2005

Abstract:Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.

Priority: US20040585804P Applic. Date: 2004-07-06

Inventor: NICOLAU CLAUDE [US]; GREFERATH RUTH [DE]; FYLAKTAKIDOU KONSTANTINA C [GR]; LEHN JEAN-MARIE [FR]


Application No.: US20060110341A1  Published: 25/May/2006

Title: Cosmetic compositions containing Sophora alopecuroides L. extracts

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/997204   Filing Date: 24/Nov/2004

Abstract:Disclosed are extracts of Sophora alopecuroides L. as cosmetic skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. Also disclosed are active ingredients in the extracts, including Alopecurone A, Alopecurone B, Sophoraflavone-G, Sophoraflavone-I, Sophoraflavone-K, and mixtures thereof. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin and are available in nature.

Priority:

Inventor: HARICHIAN BIJAN [US]; ZOU MINLIANG [CN]; WANG HONGQIANG [CN]


Application No.: US20060110342A1  Published: 25/May/2006

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/246296   Filing Date: 11/Oct/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2005-150254 Applic. Date: 2005-06-13; US2005-066485 Applic. Date: 2005-02-28; US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]


Application No.: US20060110343A1  Published: 25/May/2006

Title: Cosmetic or dermopharmaceutical compositions comprising tyramine derivatives, method for preparing same, and use thereof

Applicant/Assignee: SEDERMA SAS

Application No.: 10/519118   Filing Date: 29/Sep/2005

Abstract:The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine derivatives and their salts. The invention also concerns the method for preparing same and use thereof for reducing pigmaentation.

Priority: FR20020007965 Applic. Date: 2002-06-26; WO2003FR01950 Applic. Date: 2003-06-25

Inventor: LINTNER KARL [FR]


Application No.: US20060110379A1  Published: 25/May/2006

Title: Linkage of agents using microparticles

Applicant/Assignee: PERICOR SCIENCE, INC

Application No.: 11/125830   Filing Date: 10/May/2005

Abstract:Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.

Priority: US2000-620783 Applic. Date: 2000-07-21; US1999-359920 Applic. Date: 1999-07-22; US1999-234358 Applic. Date: 1999-01-20; US19980071908P Applic. Date: 1998-01-20

Inventor: GREEN HOWARD [US]; COMPTON BRUCE J [US]; COREY GEORGE D [US]; DJIAN PHILIPPE [FR]


Application No.: US20060110413A1  Published: 25/May/2006

Title: Novel Molecules dervied from noraporphine

Applicant/Assignee: SEDERMA SAS

Application No.: 10/525985   Filing Date: 15/Sep/2005

Abstract:The invention concerns novel molecules derived from noraporphine, as well as cosmetic and dermopharmaceutical compositions containing one or several of said derivatives, alone or combined with a plant extract, in particular glaucium flavum, and particularly preparations for reducing pigmentation, with anti-ageing effect or for slimming.

Priority: FR20020010810 Applic. Date: 2002-08-30; WO2003FR02400 Applic. Date: 2003-07-29

Inventor: LINTNER KARL [FR]


Application No.: US20060110449A1  Published: 25/May/2006

Title: Pharmaceutical composition

Applicant/Assignee:

Application No.: 11/257348   Filing Date: 24/Oct/2005

Abstract:The present invention relates to formulations useful for treating respiratory disorders associated with the production of mucus glycoprotein, skin disorders, and allergic conjunctivitis while substantially reducing adverse effects associated with the administration of non-selective anti-cholinergic agents and methods of use thereof.

Priority: US20040622507P Applic. Date: 2004-10-27; US20040621783P Applic. Date: 2004-10-25

Inventor: LORBER RICHARD R [US]; STAUDINGER HERIBERT W [US]; WARD ROBERT E [US]


Application No.: US20060111263A1  Published: 25/May/2006

Title: Derivatized polysaccharide polymer

Applicant/Assignee: RHODIA INC

Application No.: 11/282501   Filing Date: 18/Nov/2005

Abstract:Derivatized polysaccharide polymers that contain a fructan polymer substrate bearing one or more cationic substituent groups are useful in home and fabric care applications, in oilfield applications, and in emulsion polymerization applications.

Priority: US20040629402P Applic. Date: 2004-11-19

Inventor: GUNN EUEN [US]; GABBIANELLI ALVINO [US]; CROOKS REGAN [US]; SHANMUGANANDAMURTHY KRISHNAMUR [US]


Application No.: US20060111376A1  Published: 25/May/2006

Title: 2,4-Diamino quinazoline and pyridopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Applicant/Assignee:

Application No.: 10/525906   Filing Date: 14/Nov/2005

Abstract:The invention provides novel compounds or the formula II: wherein R1, R2, R3 and R4 are independently hydrogen of a group that liberates the free amine in vivo, for example -CO-alkyl, preferably -CO-C1-C3 alkyl or pivalate

or -COhaloalkyl, preferably -CO-C1-C3 haloalkyl, most preferably -CO-C1-C3 chloroalkyl

wherein W is: and @ denotes the points of attachment and wherein the ester can be located in either direction

wherein n and m are independently 0-5

wherein one but not both or X and Y can be nitrogen, or X is C-A and/or Y is C-B

wherein A and B are independently selected from hydrogen, alkyl optionally substituted with a halogen, an electron donor group such as amino, alkylamino, dialkylamino or hydroxy, or an electron acceptor group such as nitro, cyano. trihaloalkyl or amido, alkoxy or halogen

and pharmacologically acceptable salts thereof. Provided that when R1 to R4 are hydrogen, both X and Y are C-H, n is 1 and -(CH2)n- is attached to the bridging oxygen of the ester group W, then m cannot be 0 or 1.

Priority: GB20020019897 Applic. Date: 2002-08-27; WO2003GB03714 Applic. Date: 2003-08-27

Inventor: HALLBERG ANDERS [SE]; GRAFFNER-NORDBERG MALIN [SE]; BOMAN ARNE [SE]; SEIFERT ELISABETH [SE]


Application No.: US20060111416A1  Published: 25/May/2006

Title: Octahydropyrrolo[3,4-C]pyrrole derivatives

Applicant/Assignee:

Application No.: 11/285653   Filing Date: 21/Nov/2005

Abstract:The present invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives of formula (I): and to processes for the preparation thereof, compositions containing the same and the uses thereof.

Priority: EP20040106044 Applic. Date: 2004-11-24; EP20050100474 Applic. Date: 2005-01-26; US20050664619P Applic. Date: 2005-03-22

Inventor: LANE CHARLOTTE A L [GB]; PRICE DAVID A [GB]


Application No.: US20060111423A1  Published: 25/May/2006

Title: Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus-associated disease

Applicant/Assignee:

Application No.: 11/260543   Filing Date: 26/Oct/2005

Abstract:The present invention includes compositions and methods for the treatment and prevention of conditions associated with Human Cytomegalovirus (HCMV) infection. HCMV-associated conditions include infections (active and latent), benign cell-proliferative conditions, pre-cancerous cell-proliferative conditions, and cancerous conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3'-diindolylmethane (DIM), or a DIM-related indole, in combination with an inhibitor of a membrane bound Growth Factor Receptor (GFR), to treat conditions associated with exposure to HCMV. In certain embodiments, the compositions of the invention can be used in combination with radiation therapy.

Priority: US20040622333P Applic. Date: 2004-10-26

Inventor: ZELIGS MICHAEL A [US]


Application No.: US20060111633A1  Published: 25/May/2006

Title: Instantaneous ultrasonic measurement of bladder volume

Applicant/Assignee:

Application No.: 10/523681   Filing Date: 23/Sep/2005

Abstract:An apparatus and methods to quantify the volume of urine in a human bladder with a limited number of acoustic beams is disclosed. In a first version the apparatus is composed of a transducers assembly that transmits a plurality of narrow ultrasound beams in different directions towards the bladder and receives the returning ultrasound signals

a receiver detector for processing the returned signals

an analog-to-digital converter

a memory to store the digitized data and a volume display allowing to define the optimal position of the transducer assembly. The apparatus also includes a signal processing software that automatically determines the bladder Depth D and Height H and computes the volume of urine using an empirical formula corrected by specific, empirically measured, filling dependant correction factors. In a second version a single wide angle ultrasound beam transducer transmitting ultrasound signals at fundamental frequency is used to quantify the urine volume. Return signals originating from a depth beyond the usual position of the posterior wall depth of a filled bladder are analyzed for presence of higher harmonic signals which in turn are related to presence or absence of urine. Both methods or a combination thereof can be used us a simple warning device for presence of residual urine after voiding or indicate the presence of a critical bladder urine filling level.

Priority: GB20020018547 Applic. Date: 2002-08-09; WO2003EP07807 Applic. Date: 2003-07-01

Inventor: MCMORROW GERALD [US]; BAARTMANS HENRI [NL]; BOM NICOLAAS [NL]; LANCEE CHARLES T [NL]


Application No.: US20060112503A1  Published: 01/Jun/2006

Title: Solid personal care composition

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/289058   Filing Date: 29/Nov/2005

Abstract:Disclosed is a personal care composition comprising: (a) at least a solid hydrophobic component

and (b) no more than 25% by weight of the composition of a soap component, and the composition having: (i) a needle penetration, as measured according to the ASTM Test Method D5, of from about 1 to about 40 at 25 DEG C.

(ii) a yield stress of at least about 1500 Pa at 25 DEG C.

and (iii) a viscosity of between about 1 mPas and about 10,000,000 mPas at 100 DEG C.

Priority: US20040631385P Applic. Date: 2004-11-29

Inventor: HATANO SATORU [JP]; LAM VIRGINIA A [US]


Application No.: US20060113070A1  Published: 01/Jun/2006

Title: Heat exchanger of ventilating sytem

Applicant/Assignee: LG ELECTRONICS INC

Application No.: 10/538070   Filing Date: 04/Feb/2003

Abstract:A heat exchanger of a ventilating system includes: heat exchange plates having first air passage through which indoor air being discharged to outside of a building passes and a second air passage through which outdoor air of the building passes which are sequentially formed: first corrugation plates attached to the first air passage

and second corrugation plates attached to the second air passage, wherein the heat exchange plates are made of a paper material with numerous fine holes that are able to generate a capillary phenomenon and loess which radiates far infrared ray. Heat exchange and moisture exchange between the indoor air and the outdoor air are performed simultaneously, and a cleaning function of removing a harmful material contained in outdoor air can be carried out.

Priority: WO2003KR00245 Applic. Date: 2003-02-04

Inventor: LEE SEONG-HWAN [KR]; SHIN SOO-YEON [KR]


Application No.: US20060115441A1  Published: 01/Jun/2006

Title: Underarm cosmetic method and compositions

Applicant/Assignee: CONOPCO INC, D/B/A UNILEVER

Application No.: 11/284298   Filing Date: 21/Nov/2005

Abstract:A method of inhibiting skin darkening whilst inhibiting perspiration in the underarm which comprises incorporating into a antiperspirant composition comprising an astringent salt comprising an aluminium and/or zirconium salt, a triglyceride oil and optionally an active acid comprising an aliphatic dicarboxylic acid, especially C6-C12 such as azelaic acid, an unsaturated C18 aliphatic carboxylic acid such as a linoleic acid or an hydroxybenzoic acid such as salicylic acid, at a ratio to said astringent salts, x:y, of 1:<4 in which x represents the weight concentration of said triglyceride oil plus 4 times the weight concentration of active carboxylic acid and y represents the weight concentration of said astringent salts. The composition can additionally comprise glycerol and/or a chelating agent for a transition metal.

Priority: GB20040025945 Applic. Date: 2004-11-26

Inventor: JAMES ALEXANDER G [GB]; MARTI VERNON P J [GB]; PATERSON SARAH E [GB]; POPLE JENNIFER E [GB]; TURNER GRAHAM A [GB]


Application No.: US20060115480A1  Published: 01/Jun/2006

Title: Disease treatment via antimicrobial peptide inhibitors

Applicant/Assignee:

Application No.: 10/539558   Filing Date: 17/Jun/2005

Abstract:A method of treating a disease in a subject in need thereof is disclosed. The method comprises providing to the subject a therapeutically effective amount of a compound being capable of decreasing an activity and/or level of an antimicrobial peptide (AMP) and/or AMP-like molecule, thereby treating the disease in the subject in need thereof.

Priority: IL20020153557 Applic. Date: 2002-12-19; IL20030156980 Applic. Date: 2003-07-17; WO2003IL01094 Applic. Date: 2003-12-21

Inventor: HILLMAN YITZCHAK [IL]


Application No.: US20060115504A1  Published: 01/Jun/2006

Title: Cosmetic compositions comprising a fine and porous powder

Applicant/Assignee: ARKEMA FRANCE

Application No.: 11/268967   Filing Date: 08/Nov/2005

Abstract:Our invention is a water/oil emulsion comprising a porous powder, the particles of the powder having the following characteristics: an apparent specific surface of 1 to 299 m<2>/g, measured by nitrogen absorption according to the ISO 9277 BET method

a linseed oil absorption of between 45 g/100 g of powder and 160 g/100 g of powder, measured according to ISO 787-5. The mean diameter of the particles of the powder is between 2 mum and 100 mum, preferably from 2 to 50 mum, more advantageously still from 2 to 20 mum. The powder is chosen from a powder formed of polyamides, of polyesteramides, of polyurethanes, of poly(methyl methacrylate)s, of acrylic polymers, of polyesters, of silicones, of polyethylenes and of silicas.

Another subject-matter of our invention is the use of the emulsion for obtaining a make-up and/or care product for the skin which is nonshiny, nonoily, nonsticky and/or nontacky, as well as the use of the fine powder for improving the feel and/or the appearance of a cosmetic emulsion.

Priority: FR20040012690 Applic. Date: 2004-11-30

Inventor: LOYEN KARINE [FR]; KOHLER SOPHIE [FR]


Application No.: US20060115811A1  Published: 01/Jun/2006

Title: Cytochrome p450ra1-2 and related proteins

Applicant/Assignee: CYTOCHROMA INC

Application No.: 10/148883   Filing Date: 13/Feb/2003

Abstract:The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders and cancer.

Priority: US20000178314P Applic. Date: 2000-01-27; US19990171110P Applic. Date: 1999-12-16; WO2000CA01493 Applic. Date: 2000-12-15

Inventor: WHITE JAY [CA]; PETKOVICH MARTIN P [CA]; JONES GLENVILLE [CA]; RAMSHAW HEATHER [CA]


Application No.: US20060116319A1  Published: 01/Jun/2006

Title: Method for identifying and treating photodamaged skin

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/998685   Filing Date: 29/Nov/2004

Abstract:The present invention relates to modulation of MAP2K2 and DUSP-1 genes and proteins encoded thereby. More specifically, the present invention relates to modulation of MAP2K2 and DUSP-1 genes to detect and condition photo-damaged skin, preferably, chronically photo-damaged skin, as well as to identify active compounds and compositions for skin conditioning.

Priority:

Inventor: IOBST SUSANNE T [US]; SCHILLING KURT M [US]; BOYD CHARLES D [US]; URSCHITZ JOHANN G E [US]; OKIMOTO GORDON S [US]


Application No.: US20060116360A1  Published: 01/Jun/2006

Title: Method of administering anti-angiogenic agents and a method of treating disease using same

Applicant/Assignee:

Application No.: 11/288989   Filing Date: 29/Nov/2005

Abstract:A method of administering an anti-angiogenic agent to a human or an animal comprising administering the anti-angiogenic agent such that a plasma concentration of the anti-angiogenic agent in the human or animal is substantially continuously maintained above 1 ng/mL.

Priority: US20040631502P Applic. Date: 2004-11-29; US20050715238P Applic. Date: 2005-09-08; US20050732065P Applic. Date: 2005-11-01

Inventor: FOGLER WILLIAM E [US]; SIDOR CAROLYN [US]; TRESTON ANTHONY M [US]; VOLKER KIRK M [US]


Application No.: US20060116489A1  Published: 01/Jun/2006

Title: Composition containing a silicone copolymer and an AMPS-like polymer and/or organic powder

Applicant/Assignee: L'OREAL

Application No.: 11/324431   Filing Date: 04/Jan/2006

Abstract:A composition containing, in a physiologically acceptable medium, (1) at least one aqueous phase containing particles of a substantially linear block silicone copolymer, and (2) at least one polymer containing at least one monomer having an ethylenic unsaturation and a sulphonic group, and/or at least on organic powder.

Priority: FR20020000097 Applic. Date: 2002-01-04; FR20020000099 Applic. Date: 2002-01-04; FR20020000095 Applic. Date: 2002-01-04; FR20020000096 Applic. Date: 2002-01-04; US2003-334979 Applic. Date: 2003-01-02

Inventor: LENNON PAULA [FR]


Application No.: US20060118119A1  Published: 08/Jun/2006

Title: Inextensible headgear and cpap or ventilator mask assembly with same

Applicant/Assignee:

Application No.: 10/523607   Filing Date: 10/Mar/2005

Abstract:A headgear ( 200 ) for a respiratory mask ( 202 ) of a ventilator or CPAP device is provided. The headgear includes a strap portion ( 204, 206 ) formed of a substantially inextensible material. The strap portion has formed on one end thereof a connecting structure configured to connect to a mask of the ventilator or CPAP device. One advantage is that the mask will not or at least will be less inclined to lift off the face as mask pressure is increased.

Priority: US20020400686P Applic. Date: 2002-08-05; WO2003AU00988 Applic. Date: 2003-08-05

Inventor: BERTHON-JONES MICHAEL [AU]; GUNARATNAM MICHAEL K [AU]; BATEMAN PETER E [AU]; JENKINSON PHILIP J [AU]; MALOUF GORDON J [AU]


Application No.: US20060120980A1  Published: 08/Jun/2006

Title: Novel dermatological composition using bio-activating organocatalysts

Applicant/Assignee:

Application No.: 11/292227   Filing Date: 01/Dec/2005

Abstract:The invention provides novel dermatological compositions and related methods useful in the activation of skin growth factors and growth receptors. Compositions of the invention act upon follicle cells and other skin targets to induce hair growth, facilitate dermal cell repair, and enhance skin health. Compositions comprise a bio-activating organocatalyst in a pharmaceutically acceptable carrier, adapted for use on an animal's skin or hair.

Priority: US20040632479P Applic. Date: 2004-12-02

Inventor: EBERL JAMES J [US]


Application No.: US20060120986A1  Published: 08/Jun/2006

Title: Mild cleaning preparation

Applicant/Assignee:

Application No.: 10/534970   Filing Date: 21/Dec/2005

Abstract:Cosmetic preparation containing a) at least two surfactants from the group of the compounds sodium lauryl sarcosinate, sodium monoalkylphosphate, disodium lauryl sulfosuccinate, disodium cocoyl glutamate, alpha-olefin sulfonate and lauryl glucoside, with a total surfactant concentration of 3 to 1% by weight, b) one or more hydrocolloids in a total concentration of 0.05 to 1% by weight, c) one or more water-soluble salts in a concentration of 1 to 4 % by weight, respectively based on the total weight of the preparation, in addition to optionally further cosmetic or dermatological active ingredients, auxiliary agents and additives and water.

Priority: DE20021036063 Applic. Date: 2002-08-07; WO2003EP07704 Applic. Date: 2003-07-16

Inventor: ALBRECHT HARALD [DE]; KOCH PETER [DE]; RUPPERT STEPHAN [DE]; KOHUT MICHAELA [DE]


Application No.: US20060121064A1  Published: 08/Jun/2006

Title: Method of preventive treatment of allergy by mucosal administration of an allergy vaccine

Applicant/Assignee: ALK-ABELLO A/S

Application No.: 11/269681   Filing Date: 09/Nov/2005

Abstract:The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising administering an allergy vaccine containing the allergen as active substance to a mucosal surface of the subject, a) wherein the subject to be treated is sensitised so as to exhibit an IgE response specific to the allergen, b) wherein the subject to be treated is free of clinical symptoms of the allergy associated with the allergen, and c) wherein the preventive treatment is aimed at preventing or reducing subsequent clinical symptoms of the allergy associated with the allergen.

Priority: DK20040001730 Applic. Date: 2004-11-10; US20040626454P Applic. Date: 2004-11-10; US20050686914P Applic. Date: 2005-06-03

Inventor: BRIMNES JENS [DK]; KILDSGAARD JENS [DK]


Application No.: US20060121069A1  Published: 08/Jun/2006

Title: Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 11/334689   Filing Date: 18/Jan/2006

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandins analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2001-774556 Applic. Date: 2001-01-31; US20000193844P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL A [US]; MCIVER JOHN M [US]; YOUNGQUIST ROBERT S [US]


Application No.: US20060121097A1  Published: 08/Jun/2006

Title: Treatment articles capable of conforming to an underlying shape

Applicant/Assignee:

Application No.: 11/270949   Filing Date: 12/Nov/2005

Abstract:Treatment articles capable of conforming to an underlying shape and methods for their use are provided. The articles comprise a water insoluble substrate having at least one elongation zone where at least a portion of the elongation zone has been incrementally stretched. The article also includes a treatment composition which preferably delivers a skin care active. Preferred articles of the present invention comprise facial treatment masks.

Priority: US20040627566P Applic. Date: 2004-11-12

Inventor: LODGE RICHARD W [US]; MIYAMOTO MIWA [JP]; MIYAMOTO KOUICHI [JP]; OHNISHI KAZUYUKI [JP]


Application No.: US20060121099A1  Published: 08/Jun/2006

Title: Process for making nonwoven articles

Applicant/Assignee: NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION

Application No.: 11/276191   Filing Date: 17/Feb/2006

Abstract:Method for preparing an active-containing nonwoven article involving fixing active ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto a surface by normal triggering mechanisms, which include the action of a liquid or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with wettability of the fabric or paper. Additionally, ingredients incompatible and reactive with each other can be treated onto the same web and kept as separate particles fixed to the surface until released.

Priority: US2003-639845 Applic. Date: 2003-08-13; US2002-219548 Applic. Date: 2002-08-15

Inventor: SOLAREK DANIEL B [US]


Application No.: US20060121101A1  Published: 08/Jun/2006

Title: Method for oxygen treatment of intact skin

Applicant/Assignee:

Application No.: 11/269433   Filing Date: 08/Nov/2005

Abstract:Oxygen therapy for healthy or inflamed but intact skin involves placing an oxygen-generating dressing onto the skin to be treated, the oxygen-generating bandage being a one-time use dressing capable of generating oxygen for only a short period of time, not to exceed about 4 hours.

Priority: US20040634322P Applic. Date: 2004-12-08

Inventor: LADIZINSKY DANIEL A [US]


Application No.: US20060121102A1  Published: 08/Jun/2006

Title: Transdermal systems for the delivery of estrogens and progestins

Applicant/Assignee:

Application No.: 11/237284   Filing Date: 27/Sep/2005

Abstract:Transdermal systems are provided for administering an estrogen and/or a progestin to a mammalian female. The systems are monolithic, having a drug reservoir that serves as the means for ensuring adhesion to the skin during drug administration. The drug reservoir includes the active agent(s), a low molecular weight organic acid as a permeation enhancer, and an additional vehicle, in an adhesive matrix. Methods for using the systems for transdermal delivery of active agents are also provided, including methods for providing hormone replacement therapy and for preventing ovulation.

Priority: US20040613663P Applic. Date: 2004-09-27

Inventor: CHIANG CHIA-MING [US]


Application No.: US20060121133A1  Published: 08/Jun/2006

Title: Antioxidant dietary supplement compositions and methods for maintaining healthy skin

Applicant/Assignee:

Application No.: 11/273514   Filing Date: 14/Nov/2005

Abstract:Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.

Priority: US20040632481P Applic. Date: 2004-12-02; US20050708498P Applic. Date: 2005-08-16

Inventor: CHOMCZYNSKI PIOTR [US]


Application No.: US20060121489A1  Published: 08/Jun/2006

Title: High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 10/851947   Filing Date: 20/May/2004

Abstract:The present invention includes composition and methods for making and using a combinatorial library to identify thioaptamers that bind to targets on or about pathogens. Compositions, kits and methods are also provided for the identification of pathogens, e.g., viral, bacterial or other proteins related infectious disease, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.

Priority: US20030472897P Applic. Date: 2003-05-23

Inventor: GORENSTEIN DAVID G [US]; LUXON BRUCE A [US]; BARRETT ALLAN [US]; HOLBROOK MICHAEL [US]; BASSETT SUZANNE [US]; SOMASUNDERAM ANOMA [US]


Application No.: US20060122147A1  Published: 08/Jun/2006

Title: Combination preparation of hyaluronic acid and at least oe local anesthetic and the use thereof

Applicant/Assignee:

Application No.: 10/529924   Filing Date: 28/Nov/2005

Abstract:The invention relates to a combination preparation comprising an active agent A from the group hyaluronic acid, the salts and fragments thereof, at least one active agent B from the group of local anaesthetics and derivatives thereof and also if necessary further additives. These combination preparations are used for the medical treatment of degenerative and traumatic diseases of all joints, for the treatment of articular cartilage and cartilage bone defects and also meniscus and intervertebral disc lesions, such as e.g. arthrosis, articular rheumatism, osteochondritis dissecans, flake fractures, meniscus lesions and for the treatment of skin and mucous membrane changes, also from cosmetic aspects.

Priority: DE20021046340 Applic. Date: 2002-10-04; WO2003EP10822 Applic. Date: 2003-09-30

Inventor: WOHLRAB DAVID [DE]


Application No.: US20060122246A1  Published: 08/Jun/2006

Title: Cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product and/or for preventing and/or treating cellulite

Applicant/Assignee: LABORATOIRES EXPANSCIENCE

Application No.: 10/561173   Filing Date: 16/Dec/2005

Abstract:The invention relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product, and to an associated cosmetic treatment method. The invention also relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, for preventing and/or treating cellulite.

Priority: FR20030007333 Applic. Date: 2003-06-18; WO2004FR01504 Applic. Date: 2004-06-17

Inventor: MSIKA PHILIPPE [FR]; PICCIRLLI ANTOINE [FR]; PICCARDI NATHALIE [FR]


Application No.: US20060123501A1  Published: 08/Jun/2006

Title: Method for treating inflammatory disorders

Applicant/Assignee:

Application No.: 11/292007   Filing Date: 02/Dec/2005

Abstract:The invention features a method of treating an inflammatory disorder, such as sepsis, in a subject. The method involves administering to the subject an antagonist of cIAP2 expression and/or function, so that the disorder is treated.

Priority: US20040632952P Applic. Date: 2004-12-06

Inventor: KORNELUK ROBERT G [CA]; HOLCIK MARTIN [CA]; CONTE DAMIANO [CA]; LEFEBVRE CHARLES [CA]; LACASSE ERIC [CA]


Application No.: US20060123561A1  Published: 15/Jun/2006

Title: Use of water structurants to provide fabric care benefits in a non-aqueous fabric treatment system

Applicant/Assignee: THE PROCTER & GAMBLE & COMPANY

Application No.: 11/345414   Filing Date: 01/Feb/2006

Abstract:Water structurants are used in combination with a lipophilic fluid and water to deliver fabric care benefits to a fabric article in a non-aqueous fabric treatment system. Water structurants are effective in minimizing fabric damages (e.g., shrinkage, pilling, loss of shapes) from the fabric treatment process. Compositions comprising the water structurants for use in a non-aqueous fabric treating process are also disclosed. The compositions are capable of delivering the fabric care benefits to the fabric article and minimizing fabric damages.

Priority: US2002-238293 Applic. Date: 2002-09-10; US20050650395P Applic. Date: 2005-02-04; US20050687079P Applic. Date: 2005-06-03

Inventor: WANG JIPING [US]; FLEISCH KELLI A [US]; GARDNER ROBB R [US]; RADOMYSELSKI ARSENI V [US]


Application No.: US20060127318A1  Published: 15/Jun/2006

Title: Composition and method of a topical treatment of neurodermatitis

Applicant/Assignee: BIONICS PHARMA GMBH

Application No.: 11/272881   Filing Date: 15/Nov/2005

Abstract:A composition for the topical treatment of dermal irritation and pain symptoms of neurodermatitis comprising a topical pharmaceutical formulation which contains a therapeutically appropriate dose of a sodium channel blocker selected from the group of ester- or amide-type local anesthetics, wherein the sodium channel blocker is released directly on or in the skin underneath the applied pharmaceutical formulation.

Priority: DE200410059613 Applic. Date: 2004-12-10

Inventor: LIEDTKE RAINER K [DE]


Application No.: US20060127343A1  Published: 15/Jun/2006

Title: Administration of urea compounds for combating signs of cutaneous aging

Applicant/Assignee: L'OREAL

Application No.: 11/260139   Filing Date: 28/Oct/2005

Abstract:Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

Priority: FR20040011783 Applic. Date: 2004-11-04; US20040634540P Applic. Date: 2004-12-10

Inventor: BERNARD DOMINIQUE [FR]; SIMONETTI LUCIE [FR]


Application No.: US20060127371A1  Published: 15/Jun/2006

Title: ASB transcription repressor proteins and nucleic acids and their application in expansion of stem cells

Applicant/Assignee:

Application No.: 10/536491   Filing Date: 25/Nov/2003

Abstract:The present invention relates to methods for expansion of stem or progenitor cells. These methods rely on Asb-a polypeptides or nucleic acids to temporarily suppress differentiation of the cells, thus allowing proliferation and self-renewal of the stem or progenitor cells. Abs-a polypeptides and coding sequences define a class of polypeptides and nucleic acids that are both structurally and functionally highly conserved among vertebrates. Asb-a polypeptides contain 6 ankyrin repeats and a SOCS box that mediate the effect of the polypeptide on the regulation of specific subsets of genes involved in differentiation. The invention discloses various methods to increase the intracellular concentration of an Asb-a polypeptide for suppression of terminal differentiation of the stem or progenitor cells. The invention further relates to Asb-a polypeptides and nucleic acids, vectors and host cells for use in methods for their production and for use in the method for expansion of stem or progenitor cells, as well as to stem or progenitor cells containing exogenous Asb-a polypeptides and nucleic acids.

Priority: EP20020079903 Applic. Date: 2002-11-25; WO2003NL00831 Applic. Date: 2003-11-25

Inventor: PEPPELENBOSCH MAIKEL P [NL]; ZIVKOVIC DANICA [NL]; DIKS SANDER [NL]; BINK ROBERT J [NL]


Application No.: US20060127393A1  Published: 15/Jun/2006

Title: Antibodies to Dkk-1

Applicant/Assignee: AMGEN INC

Application No.: 11/197665   Filing Date: 04/Aug/2005

Abstract:The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

Priority: US20040598791P Applic. Date: 2004-08-04

Inventor: LI JI [US]; SHEN WENYAN [US]; LU HSIENG S [US]; RICHARDS WILLIAM G [US]


Application No.: US20060127426A1  Published: 15/Jun/2006

Title: Cosmetic effervescent cleansing pillow with rupturable packet

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/010253   Filing Date: 13/Dec/2004

Abstract:A cleansing article is provided which includes an effervescent cleanser composition held within a rupturable packet and the packet is held within a porous receptacle. The effervescent cleanser composition is an intimate mixture of an acid material such as citric acid, an alkaline material such as sodium bicarbonate, and a surfactant.

Priority:

Inventor: ROSS MICHAEL E [US]; STEIGER DENNIS I [US]


Application No.: US20060127430A1  Published: 15/Jun/2006

Title: Controlled-Release of Cosmetic and Pharmaceutical Agents via Osmotic Nano-Diffusion from Zeolite Cage Complexes

Applicant/Assignee: BIODERM RESEARCH

Application No.: 11/307824   Filing Date: 24/Feb/2006

Abstract:The present invention discloses the application of cage complexes of zeolites for topical controlled delivery of organic cosmetic and pharmaceutical active agents. The treatment and protection of skin surface requires that certain organic cosmetic and pharmaceutical active agents be delivered slowly and allowed to remain on skin surface for extended periods. Zeolite cage complexes of the present invention do not absorb into skin and affect a controlled release of cosmetic and pharmaceutical agents by an osmotic nano-diffusion method upon contact with water. Topical treatments that includes skin aging, anti-wrinkle, antioxidants, skin whitening, acne, rosacea, sun screens, UV blocks, anesthetics, skin soothers, anti-irritants, anti-inflammatory agents, vitamins, hormones, and such that require a controlled release of active agents are now practical by the present invention.

Priority: US2003-418495 Applic. Date: 2003-04-18

Inventor: GUPTA SHYAM K [US]


Application No.: US20060127431A1  Published: 15/Jun/2006

Title: Regulation of mammalian hair growth

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/344771   Filing Date: 01/Feb/2006

Abstract:The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt

a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives

and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

Priority: US2004-783151 Applic. Date: 2004-02-19; US20030451910P Applic. Date: 2003-03-04

Inventor: OBLONG JOHN E [US]; MCPHAIL SARA J [US]; MCARTHUR SHANNON C [US]; BASCOM CHARLES C [US]; EICKHOFF DAVID J [US]; MCIVER JOHN M [US]


Application No.: US20060127873A1  Published: 15/Jun/2006

Title: Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors

Applicant/Assignee:

Application No.: 10/521524   Filing Date: 20/Sep/2005

Abstract:The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.

Priority: US20020395991P Applic. Date: 2002-07-16; WO2003CA01069 Applic. Date: 2003-07-16

Inventor: HOEMANN CAROLINE [CA]; CHENITE ABDELLATIF [CA]; BUSCHMANN MICHAEL [CA]; SARREQI ALESSIO [CA]; SUN JUN [CA]


Application No.: US20060128588A1  Published: 15/Jun/2006

Title: Enzyme stabilization

Applicant/Assignee:

Application No.: 11/297697   Filing Date: 08/Dec/2005

Abstract:A method is disclosed for stabilizing liquid enzyme-containing liquid formulations by adding at least one boron compound and at least one alpha-hydroxy-mono-carboxylic acid or the salt of an alpha-hydroxy-mono-carboxylic acid capable of forming an enzyme-stabilizing compound. An enzyme-stabilized formulation is disclosed comprising an alpha-hydroxy-mono-carboxylic acid or the salt of an alpha-hydroxy-mono-carboxylic acid, a boron containing compound capable complexing with an alpha-hydroxy-mono-carboxylic acid, the complex formed by the boron compound and the an alpha-hydroxy-mono-carboxylic acid, and an enzyme. The invention applies to both enzyme concentrate raw materials, and to useful product formulations.

Priority: US20040634564P Applic. Date: 2004-12-09

Inventor: LENOIR PIERRE M [CH]


Application No.: US20060128592A1  Published: 15/Jun/2006

Title: Cosmetic effervescent cleansing pillow with water soluble or dispersible packet

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/009659   Filing Date: 10/Dec/2004

Abstract:A cleansing article is provided which includes an effervescent cleanser composition held within a water-soluble packet and the packet is held within a receptacle formed from a first and second substrate sheet. At least a portion of one of the substrate sheets must be water permeable. The effervescent cleanser composition is an intimate mixture of an acid material such as citric acid, an alkaline material such as sodium bicarbonate, and a surfactant.

Priority:

Inventor: ROSS MICHAEL E [US]; TURBETT JAMES L [US]; LAGATOL SHAUNA M [US]


Application No.: US20060128766A1  Published: 15/Jun/2006

Title: Triazole substituted aminobenzophenone compounds

Applicant/Assignee: LEO PHARMA A/S

Application No.: 11/292064   Filing Date: 02/Dec/2005

Abstract:The invention relates to novel compounds according to formula Ia and Ib, said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases, or cancer.

Priority: US20040635000P Applic. Date: 2004-12-13

Inventor: ERIK RYTTER OTTOSEN [DK]


Application No.: US20060128770A1  Published: 15/Jun/2006

Title: Thiazole derivatives

Applicant/Assignee: FUJISAWA PHARMACEUTICAL CO. LTD

Application No.: 11/345492   Filing Date: 02/Feb/2006

Abstract:A compound of the formula (I): R<1>-NH-X-Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

Priority: US2004-764529 Applic. Date: 2004-01-27; US20030442509P Applic. Date: 2003-01-27; US20030458369P Applic. Date: 2003-03-31; US20030517377P Applic. Date: 2003-11-06

Inventor: INOUE TAKAYUKI [JP]; TOJO TAKASHI [JP]; MORITA MASATAKA [JP]; OHKUBO MITSURU [JP]; YOSHIHARA KOUSEI [JP]; NAGASHIMA AKIRA [JP]


Application No.: US20060129025A1  Published: 15/Jun/2006

Title: Systems for and methods of atrioventricular valve regurgitation and reversing ventricular remodeling

Applicant/Assignee:

Application No.: 10/519585   Filing Date: 27/Jun/2003

Abstract:Methods of and devices for restoring the normal geometry of a heart, including but not limited to the structures supporting the atrioventricular valves. The techniques and devices described herein operate on the principle of displacement, both active and passive, to reverse cardiac remodeling and limit ischemic atrioventricular valve regurgitation.

Priority: US20020392332P Applic. Date: 2002-06-27; WO2003US20450 Applic. Date: 2003-06-27

Inventor: LEVINE ROBERT A [US]; HUNG JUDY W [US]; GUERRERO J LUIS [US]; VLAHAKES GUS J [US]


Application No.: US20060129057A1  Published: 15/Jun/2006

Title: Active muscle display device

Applicant/Assignee: NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY

Application No.: 10/527087   Filing Date: 14/Nov/2005

Abstract:In order to provide an active muscle display unit that extracts a firing pattern of the individual motor unit without applying a load to living organisms and display the extracted motor unit, the active muscle display unit comprises multiple electrodes 1 that are arranged on a skin surface, a surface electromyogram measuring part 32 that measures a surface electromyogram on the skin surface at the multiple electrodes 1, a motor unit separating part 33 that estimates the individual motor unit constituting an active muscle based on the surface electromyogram measured by the surface electromyogram measuring part 32, a motor unit position estimating part 35 that estimates a three-dimensional position of the firing motor unit based on the motor unit estimated to be the firing motor unit by the motor unit separating part 33,

and a display part 38 that displays the motor unit estimated by the motor unit position estimating part 35 in an image.

Priority: WO2002JP09302 Applic. Date: 2002-09-11

Inventor: MAEKAWA SATOSHI [JP]; FUJIWARA YOSHIHISA [JP]; KOTANI MANABU [JP]; ARIMOTO TAKAHIKO [JP]; KOTANI HIROKO [JP]


Application No.: US20060134044A1  Published: 22/Jun/2006

Title: Cosmetic composition comprising a sequenced polymer and a plasticizer

Applicant/Assignee:

Application No.: 10/529318   Filing Date: 25/Mar/2005

Abstract:A subject matter of the invention is a cosmetic composition comprising a cosmetically acceptable organic liquid medium, a block polymer and a plasticizer, characterized in that: the block polymer is a film-forming linear ethylenic polymer, the plasticizer is a compound, the nature and the amount of which are such that the composition is capable of forming a film having a hardness of less than or equal to 35 seconds, the hardness of the film being measured using a Persoz pendulum according to Standard NF-T-30-016, and in particular a compound having a solubility parameter deltah ranging from 5.5 to 11 (J/cm<3>)<1/2>. Application to making-up and caring for keratinous substances, in particular the skin.

Priority: FR20020011949 Applic. Date: 2002-09-26; FR20020016437 Applic. Date: 2002-12-20; FR20030006121 Applic. Date: 2003-05-21; WO2003FR02844 Applic. Date: 2003-09-26

Inventor: BLIN XAVIER [FR]; FERRARI VERONIQUE [FR]


Application No.: US20060134047A1  Published: 22/Jun/2006

Title: Personal care and household compositions of hydrophobically-modified polysaccharides

Applicant/Assignee:

Application No.: 11/300628   Filing Date: 14/Dec/2005

Abstract:A conditioning composition is used in functional systems (personal care and household care compositions) that has a nonionic hydrophobically modified cellulose ether (HMCE) having a weight average molecular weight (Mw) with a lower limit of 400,000 and an upper limit of 2,000,000 and a hydrophobic substitution lower limit of 0.6 wt % and an upper limit amount which renders said cellulose ether insoluble in a 5 wt % solution of surfactant and less than 0.05% by weight soluble in water and wherein the cellulose ether provides conditioning benefit to the functional system substrate. This composition has at least one active functional system ingredient.

Priority: US20040636682P Applic. Date: 2004-12-16

Inventor: BAKEEV KIRILL N [US]; ERAZO-MAJEWICZ PAQUITA [US]; MODI JASHAWANT J [US]; NGUYEN TUYEN T [US]; RMAILE HASSAN H [US]


Application No.: US20060134095A1  Published: 22/Jun/2006

Title: Antioxidative composition and composition for external use

Applicant/Assignee:

Application No.: 10/543529   Filing Date: 13/Sep/2005

Abstract:As a technical means of enabling the application of a fullerene and an analogue thereof in various fields relating to biocompatibility to achieve a novel function, in particular as a means of applying the same to a cosmetic product, a formulated skin preparation for external use or the like, an antioxidative composition comprising as an active ingredient at least one kind of a fullerene, a fullerene-containing oxygen derivative and the fullerene and the fullerene-containing oxygen derivative modified with or clathrated in an organic compound is prepared.

Priority: JP20030017866 Applic. Date: 2003-01-27; JP20030086523 Applic. Date: 2003-02-20; WO2004JP00699 Applic. Date: 2004-01-27

Inventor: ITO SHINOBU [JP]; MATSUBAYASHI KENJI [JP]


Application No.: US20060134110A1  Published: 22/Jun/2006

Title: CD55-Interaction partners and the uses thereof

Applicant/Assignee: CANCER REASEARCH TECHNOLOGY LIMITED

Application No.: 10/536636   Filing Date: 22/Aug/2005

Abstract:The invention relates to the use of a binding member which binds to both SCR1 and SCR2 of CD55 in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to SCR1 and SCR2 of CD55 and neutralising CD55 and making cancer cells susceptible to complement mediated attack.

Priority: GB20020027644 Applic. Date: 2002-11-27; WO2003GB05163 Applic. Date: 2003-11-26

Inventor: DURRANT GILLIAN L [GB]


Application No.: US20060134140A1  Published: 22/Jun/2006

Title: Compositions and methods for treating tumor spreading

Applicant/Assignee:

Application No.: 10/902878   Filing Date: 02/Aug/2004

Abstract:Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a cancer in a mammal. The compositions can each effect or arrest combination of two or more of tumor cell proliferation, migration, angiogenesis, and metalloproteinase secretion.

Priority: US20030506162P Applic. Date: 2003-09-29; US2002-118079 Applic. Date: 2002-04-09; CA20022367636 Applic. Date: 2002-01-15; CA20012362004 Applic. Date: 2001-11-13; CA20012342970 Applic. Date: 2001-04-12

Inventor: LASKO DANA [CA]; MCKERRACHER LISA [CA]


Application No.: US20060134151A1  Published: 22/Jun/2006

Title: Novel sulfamide derivatives and cosmetic use thereof

Applicant/Assignee: L'OREAL

Application No.: 11/289551   Filing Date: 30/Nov/2005

Abstract:The present invention relates to the cosmetic use of a compound of formula (I) and also the cosmetically acceptable salts thereof, solvates thereof and isomers thereof, for non-therapeutic skincare. The invention also relates to compounds of general formula (II)

Priority: FR20040052821 Applic. Date: 2004-11-30; US20040638371P Applic. Date: 2004-12-27

Inventor: MARAT XAVIER [FR]; MULLER BENOIT [FR]


Application No.: US20060134155A1  Published: 22/Jun/2006

Title: Compositions and methods of their use for improving the condition and appearance of skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/021242   Filing Date: 22/Dec/2004

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and/or aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include active agents which increase expression levels of genes associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and/or aesthetic appearance of skin.

Priority:

Inventor: DRYER LAURENCE [US]; PTCHELINTSEV DMITRI [US]


Application No.: US20060134156A1  Published: 22/Jun/2006

Title: Method for caring for the skin and associated kit

Applicant/Assignee: L'OREAL

Application No.: 11/287420   Filing Date: 28/Nov/2005

Abstract:The present invention relates to a method for caring for the skin, intended to soften cutaneous signs of ageing, by the successive application to the skin, wetted beforehand, of four compositions, namely: a microdermabrasion composition, a peeling composition, a soothing composition and an anti-ageing composition having a given constitution. It also relates to a kit having four separate packagings, each of which includes one of the abovementioned compositions.

Priority: FR20040053043 Applic. Date: 2004-12-17; US20050663202P Applic. Date: 2005-03-21

Inventor: MARION CATHERINE [FR]


Application No.: US20060134186A1  Published: 22/Jun/2006

Title: Oxygenating agents for enhancing host responses to microbial infections

Applicant/Assignee:

Application No.: 10/509285   Filing Date: 27/Jun/2005

Abstract:Oxygenating agents are used in the present invention for the novel purpose of treating microbial infections. The invention takes advantage of the fact that the increase in tissue pO2 produced thereby can enhance the efficacy of the body's own antimicrobial defenses (including tissue repair), while also improving the efficacy of adjunctive agents that may be co-administered, such as antimicrobial agents, antioxidants, cytokine modulators, endotoxin antagonists and growth factors. The oxygenating agents of the present invention achieve the desired increased pO2 in the tissues without having to resort to the risks and expenses of hyper-baric oxygen therapy (HBO). The oxygenating agents can be administered systemically, regionally, or topically.

Priority: US20020367732P Applic. Date: 2002-03-28; WO2003US09226 Applic. Date: 2003-03-26

Inventor: CARLTON RICHARD M [US]; GALPIN JEFFREY E [US]


Application No.: US20060134221A1  Published: 22/Jun/2006

Title: Methods for producing block copolymer/amphiphilic particles

Applicant/Assignee: VICAL INCORPORATED

Application No.: 11/292280   Filing Date: 02/Dec/2005

Abstract:The invention relates to a method for manufacturing cell delivery particles, pharmaceutical component-particle dispersions, compositions comprising cell delivery particles and pharmaceutical compositions comprising pharmaceutical component-particle dispersions. The method comprises homogenization of mixtures comprising amphiphilic components and a block copolymer to form stable particles. The invention is also directed to cell delivery particles and pharmaceutical component-particle dispersions produced by the claimed methods and compositions comprising same. In certain embodiments, the cell delivery particles may further comprise co-lipids. The invention further relates to methods of generating an immune response, treating or preventing a disease or condition, or delivering a biologically active molecule to cells in vitro comprising administration of the pharmaceutical compositions described herein.

Priority: US20040632612P Applic. Date: 2004-12-03

Inventor: GEALL ANDREW [US]


Application No.: US20060135385A1  Published: 22/Jun/2006

Title: Reduced odor toilet bar composition

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO., INC

Application No.: 11/151112   Filing Date: 13/Jun/2005

Abstract:Toilet bar compositions are described that contain specific odor masking agent(s). The odor masking agent(s) reduce malodor without the need for elevated amounts of masking fragrances that individuals may not prefer and who use the composition for personal cleansing or who are exposed to the composition.

Priority: US2004-019794 Applic. Date: 2004-12-22

Inventor: MASSARO MICHAEL [US]; MERAVIGLIA SANDRA D [US]; ABBAS SYED H [US]; KHARA BIPINCHANDRA J [US]; SHEVADE MAKARAND S [US]; VAN VLIJMEN MICHAEL B [US]


Application No.: US20060135392A1  Published: 22/Jun/2006

Title: Cleansing composition in the form of an aerosol foam without anionic surfactant, and uses in cosmetics

Applicant/Assignee: L'OREAL S.A

Application No.: 11/287298   Filing Date: 28/Nov/2005

Abstract:The present disclosure relates to foaming cleansing compositions without anionic surfactant, comprising, in a cosmetically acceptable medium: a) greater than 2% by weight in terms of active material of a non-betaine amphoteric or zwitterionic surfactant, relative to the total weight of the composition, b) at least one non-ionic surfactant, c) at least one propellant. The present disclosure also relates to aerosol devices containing such a composition and also to the use of these compositions in cosmetics or dermatology, for instance for cleansing keratin materials such as the skin, the hair or the scalp.

Priority: FR20040052773 Applic. Date: 2004-11-26; US20040635960P Applic. Date: 2004-12-15

Inventor: RIBERY DELPHINE [FR]; PENVERNE ISABELLE [FR]


Application No.: US20060135397A1  Published: 22/Jun/2006

Title: Liquid cleansing composition comprising at least one anionic surfactant and its use for cleansing human keratin materials

Applicant/Assignee: L'OREAL S.A

Application No.: 11/287300   Filing Date: 28/Nov/2005

Abstract:The present disclosure relates to a liquid cleansing composition, comprising, in a cosmetically acceptable aqueous medium: (a) at least one anionic surfactant

(b) at least one electrolyte, (c) at least one copolymer of methacrylic acid and of a C1-C4 alkyl acrylate, present in an amount of less than 0.5% by weight of active material, relative to the total weight of the composition. The present disclosure also relates to the use of the compositions in cosmetics or dermatology, such as products for cleansing human keratin materials, for instance the skin, and to their use for improving the stability of the texture of the composition at low temperature.

Priority: FR20040052780 Applic. Date: 2004-11-26; US20040634542P Applic. Date: 2004-12-10

Inventor: BISSEY-BEUGRAS LAURE [FR]; RIBERY DELPHINE [FR]


Application No.: US20060135513A1  Published: 22/Jun/2006

Title: Methods of treating tumors

Applicant/Assignee:

Application No.: 11/350313   Filing Date: 07/Feb/2006

Abstract:The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.

Priority: US2002-301263 Applic. Date: 2002-11-21; US2000-730666 Applic. Date: 2000-12-06; US19990169122P Applic. Date: 1999-12-06; US19990169127P Applic. Date: 1999-12-06; US19990169128P Applic. Date: 1999-12-06

Inventor: CALABRESI PAUL [US]; DARNOWSKI JAMES [US]


Application No.: US20060135587A1  Published: 22/Jun/2006

Title: Method and compounds for promoting healing and reducing inflammation

Applicant/Assignee:

Application No.: 10/519645   Filing Date: 22/Sep/2005

Abstract:This invention relates to methods of promoting healing and reducing inflammation, and compositions therefore. In particular, the invention relates to the use of 1,3-dialkyl-4,5-bis(N-methylcarbamoyl)imidazolium salts to promote wound healing and to reduce inflammation. Novel compounds and compositions are also provided. In one preferred embodiment the invention provides a method of treatment of myocardial infarction.

Priority: RU20020120366 Applic. Date: 2002-08-01; WO2003AU00972 Applic. Date: 2003-07-31

Inventor: SAPRONOV NIKOLAY S [RU]; PIOTROVSKY LEVON B [RU]; GAVROVSKAYA LUIDMILA K [RU]


Application No.: US20060135620A1  Published: 22/Jun/2006

Title: Novel compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection

Applicant/Assignee: NOVAREMED LIMITED

Application No.: 10/530116   Filing Date: 29/Nov/2005

Abstract:The present invention provides compounds, pharmaceutical compositions and methods for treating, immuno-allergical diseases, autoimmune diseases, and organ or tissue rejection following transplantation.

Priority: US20020415508P Applic. Date: 2002-10-03; WO2003IB04993 Applic. Date: 2003-10-01

Inventor: KAPLAN ELIAHU [IL]


Application No.: US20060135640A1  Published: 22/Jun/2006

Title: Low peak exotherm curable compositions

Applicant/Assignee:

Application No.: 11/214207   Filing Date: 29/Aug/2005

Abstract:Compositions having a curable unsaturated compound, an adhesion promoter and curing agent which have a peak exotherm of less than 50.degree. C. are disclosed. The compositions when cured are flexible bioadhesives which are also disclosed. Non-curable diluents can be included in the compositions. Flexible bioadhesives formed on biological structures and having low peak exotherms upon curing of curable compositions to form the flexible bioadhesives are disclosed. Compositions having a curable unsaturated compound and a curing agent and a peak exotherm of less than 50.degree. C. are included in the invention.

Priority: US2004-925583 Applic. Date: 2004-08-25; US2000-552994 Applic. Date: 2000-04-21

Inventor: MONTGOMERY ROBERT E [US]; CIPOLLA ANTHONY J [US]


Application No.: US20060135906A1  Published: 22/Jun/2006

Title: Iontophoretic device and method for administering immune response-enhancing agents and compositions

Applicant/Assignee:

Application No.: 11/280805   Filing Date: 16/Nov/2005

Abstract:An iontophoresis device and method delivers an immune response-enhancing agent, or composition thereof via iontophoresis. The device may include an active electrode assembly having a drug solution holding portion, comprising an immune response-enhancing agent, or composition thereof

and a non-active electrode assembly. An iontophoresis device delivers an immune response-enhancing agent via iontophoresis. The device includes an active electrode assembly and a non-active electrode assembly, wherein the active electrode assembly comprises: a first electrode element operable to provide an electrical potential of a first polarity and a drug solution holding portion arranged on a front surface of the first electrode member.

Priority: US20040627952P Applic. Date: 2004-11-16; US20050714538P Applic. Date: 2005-05-16; US2005-129321 Applic. Date: 2005-05-16

Inventor: MATSUMURA AKIHIKO [JP]; REED STEVEN G [US]


Application No.: US20060140894A1  Published: 29/Jun/2006

Title: Olefin wax, silicone-modified olefin waxes, silicone-base cold-setting compositions made by using the same, and cosmetics containing the same

Applicant/Assignee: SHIN-ETSU CHEMICAL CO. LTD

Application No.: 10/531377   Filing Date: 26/Sep/2005

Abstract:An olefin wax (A) is (i) a copolymer (A1) obtained by copolymerizing ethylene and at least one diene or a copolymer (A2) obtained by copolymerizing ethylene, at least one olefin selected from alpha-olefins of 3 to 12 carbon atoms and at least one diene

wherein (ii) the content of unsaturated groups per one molecule is in the range of 0.5 to 3.0 groups

(iii) the density is in the range of 870 to 980 kg/m<3>

(iv) the melting point is in the range of 70 to 130 DEG C.

(v) the number-average molecular weight is in the range of 400 to 5,000

and (vi) the ratio (Mw/Mn) of the weight-average molecular weight to the number-average molecular weight is not more than 4.0. A silicone-modified olefin wax can be obtained by reacting hydrogen silicone with the olefin wax (A). Cosmetics contain the silicone-modified olefin wax.

Priority: JP20020302202 Applic. Date: 2002-10-16; WO2003JP13265 Applic. Date: 2003-10-16

Inventor: TOYODA HIDEO [JP]; UOSAKI HIROTAKA [JP]; KAN KOUJIRO [JP]; ICHINOHE SHOJI [JP]; SHIMIZU TORU [JP]


Application No.: US20060140984A1  Published: 29/Jun/2006

Title: Cosmetic and pharmaceutical foam

Applicant/Assignee: FOAMIX LTD

Application No.: 10/532618   Filing Date: 22/Dec/2005

Abstract:The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.

Priority: IL20020152486 Applic. Date: 2002-10-25; US20020429546P Applic. Date: 2002-11-29; WO2003IB05527 Applic. Date: 2003-10-24

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20060140995A1  Published: 29/Jun/2006

Title: Methods for treating ectoparasite infections on the mammalian body

Applicant/Assignee:

Application No.: 10/519372   Filing Date: 23/Dec/2004

Abstract:Methods for treating ectoparasites, their nymphs, and their egg infestations on animal skin and hair, wherein the compositions used in the methods contain at least one monohydric aralkyl alcohol in a quantity sufficient to provide pesticidal activity

the compositions are applied to the infected areas in a quantity sufficient to completely saturate both the hair and the skin in the infected areas with the composition

and the compositions can be readily washed out of the infected areas by rinsing with water.

Priority:

Inventor: PRECOPIO MICHAEL J [US]


Application No.: US20060141046A1  Published: 29/Jun/2006

Title: Particles for the delivery of active agents

Applicant/Assignee: IVREA PHARMACEUTICALS, INC

Application No.: 11/283064   Filing Date: 17/Nov/2005

Abstract:Formulations of active agent particles of less than 100 microns in a droplet of dispersant, which is coated with a matrix of cationic and anionic polymers, are efficient vehicles for delivering active agents to tissues such as skin and mucosal membranes. Such formulations are able to deliver compounds to skin with little associated irritation. Prior art topical formulations typically have the disadvantage of causing significant skin irritation.

Priority: US2005-123958 Applic. Date: 2005-05-06; US2004-839907 Applic. Date: 2004-05-06; US20040634885P Applic. Date: 2004-12-09

Inventor: CATTANEO MAURIZIO V [US]


Application No.: US20060141078A1  Published: 29/Jun/2006

Title: Composition comprising a rice protein hydrolysate and an agent for increasing glycosaminoglycan synthesis

Applicant/Assignee: L'OREAL

Application No.: 11/266287   Filing Date: 04/Nov/2005

Abstract:The present invention relates to a process for preventing and/or reducing the signs of ageing of the skin, in particular for remodelling the face and/or limiting the age-related hollowing of the face, by applying to facial skin a composition containing, in a physiologically acceptable medium, at least one rice protein hydrolysate and at least one agent for increasing glycosaminoglycan synthesis.

Priority: FR20040052593 Applic. Date: 2004-11-10; US20050643172P Applic. Date: 2005-01-13

Inventor: GUILLOU VERONIQUE [FR]; THIRY ANNABELLE [FR]


Application No.: US20060141598A1  Published: 29/Jun/2006

Title: Promotion of peroxisomal catalase function in cells

Applicant/Assignee: WAYNE STATE UNIVERSITY

Application No.: 10/533124   Filing Date: 27/Dec/2005

Abstract:The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor. Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Disclosed are novel compositions and methods for restoring catalase in peroxisomes by use of targeted catalase modified at its C-terminus and/or N-terminus, optionally in combination with polypeptides which promote cellular uptake of proteins, to prevent or overcome the changes that follows aging or that are associated with a number of diseases or disorders.

Priority: US20020422100P Applic. Date: 2002-10-30; WO2003US34512 Applic. Date: 2003-10-30

Inventor: TERLECKY STANLEY R [US]; WALTON PAUL A [CA]


Application No.: US20060142203A1  Published: 29/Jun/2006

Title: Compositions and methods comprising protein activated receptor antagonists

Applicant/Assignee:

Application No.: 10/608886   Filing Date: 26/Jun/2003

Abstract:Compositions and methods comprising protein activated receptor antagonists are provided More particularly, the present invention relates to the use of proteins, peptides and biomolecules that bind to protein activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.

Priority: US20020391655P Applic. Date: 2002-06-26; US20020398662P Applic. Date: 2002-07-26; US20030458095P Applic. Date: 2003-03-27; US20030466296P Applic. Date: 2003-04-29

Inventor: HEMBROUGH TODD [US]; PRIBLUDA VICTOR [US]


Application No.: US20060142304A1  Published: 29/Jun/2006

Title: Method for treating or preventing pruritic and neurogenic skin disorders

Applicant/Assignee:

Application No.: 11/315773   Filing Date: 22/Dec/2005

Abstract:This invention relates to methods of treatments, compositions, and kits for providing rapid relief to the user for pruritic and neurogenic skin disorders. The invention also provides methods of treatments, compositions, and kits for preventing such conditions.

Priority: US20040639382P Applic. Date: 2004-12-27

Inventor: SOUTHALL MICHAEL [US]; LIEBEL FRANK [US]


Application No.: US20060142373A1  Published: 29/Jun/2006

Title: Medicaments for the Treatment or Prevention of Fibrotic Diseases

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/275223   Filing Date: 20/Dec/2005

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030770 Applic. Date: 2004-12-24

Inventor: PARK JOHN E [DE]; ROTH GERALD J [DE]; HECKEL ARMIN [DE]; CHAUDHARY NVEED [DE]; BRANDL TRIXI [DE]; DAHMANN GEORG [DE]; GRAUERT MATTHIAS [DE]


Application No.: US20060147377A1  Published: 06/Jul/2006

Title: Animal model for the fast identification of pharmaceutical active compounds in vivo

Applicant/Assignee: JANSSEN PHARMACEUTICA N.V

Application No.: 10/547518   Filing Date: 03/Mar/2004

Abstract:In a first aspect the present invention provides a tumor cell line stably transfected with an expression vector containing a reporter gene, preferably a fluorescent protein, operably linked to a promotor that also controls expression of a protein that is associated with tumor regression, stabilisation of tumor growth or inhibition of metastatic growth, characterised in that said cell line is capable to form a tumor when implanted or injected into the non-human animal. Compared to the traditional in vivo models, the present invention differs in that the reporter gene is not constitutively expressed, but only after exposure to a test compound that results in the expression of a protein or enzyme associated with tumor regression, stabilisation of tumor growth or inhibition of metastatic growth.

Only when a compound to be tested got into circulation and infiltrated the tumor it may generate the reporter signal, provided it promotes the expression of a protein associated with tumor regression and the promoter of said protein is operably linked to the reporter gene.

Priority: WO2003EP02264 Applic. Date: 2003-03-05; WO2004EP02195 Applic. Date: 2004-03-03

Inventor: BELIEN ANN T J [BE]; ARTS JANINE [BE]; MARIEN ANN O A [BE]; VALCKX ANNEMIE F [BE]


Application No.: US20060147383A1  Published: 06/Jul/2006

Title: Sprayable compositions comprising pharmaceutical active agents, volatile silicones and a non-volatile oily phase

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/315259   Filing Date: 23/Dec/2005

Abstract:Compositions in the form of a spray contain a pharmaceutical active agent, at least one volatile silicone and a non-volatile oily phase, formulated into a physiologically acceptable medium, are well suited for improved transdermal administration in cosmetics and dermatology.

Priority: FR20030007551 Applic. Date: 2003-06-23; WO2004EP07203 Applic. Date: 2004-06-18

Inventor: MALLARD CLAIRE [FR]; PITRE FRANCK [FR]; FREDON LAURENT [FR]


Application No.: US20060147396A1  Published: 06/Jul/2006

Title: Composition containing ascorbic acid

Applicant/Assignee: L'OREAL

Application No.: 11/322216   Filing Date: 03/Jan/2006

Abstract:The invention relates to a composition in oil-in-water emulsion form containing ascorbic acid or a derivative thereof, at least one polysaccharide hydrophilic gelling agent, at least one C16-C22 fatty acid sorbitan ester, at least one ethoxylated fatty acid ester and at least one polymer containing a sulpho-functional monomer.

Priority: FR20050050008 Applic. Date: 2005-01-03; US20050641741P Applic. Date: 2005-01-07

Inventor: MONELLO ALDO [FR]


Application No.: US20060147403A1  Published: 06/Jul/2006

Title: Non-transfer cosmetic composition comprising a sequenced polymer

Applicant/Assignee: L'OREAL C.A

Application No.: 10/529264   Filing Date: 19/Dec/2005

Abstract:The invention relates to a cosmetic composition comprising at least one cosmetically acceptable organic liquid medium and at least one film-forming linear block ethylenic polymer, the said polymer being such that, when it is present in sufficient amount in the composition, the said composition is capable of forming a deposit that has a transfer of less than or equal to 35%. Application to making up and caring for keratin materials, especially the skin and the lips.

Priority: FR20020011949 Applic. Date: 2002-09-26; FR20020016437 Applic. Date: 2002-12-20; FR20030006121 Applic. Date: 2003-05-21; WO2003FR02845 Applic. Date: 2003-09-26

Inventor: FERRARI VERONIQUE [FR]; BLIN XAVIER [FR]; LION BERTRAND [FR]


Application No.: US20060147430A1  Published: 06/Jul/2006

Title: Adipose-derived stem cells for tissue regeneration and wound healing

Applicant/Assignee: PRIMEGEN BIOTECH LLC

Application No.: 11/323276   Filing Date: 30/Dec/2005

Abstract:Compositions and methods for promoting tissue regeneration, particularly skin regeneration, with adipose-derived stem cells are provided. Additionally methods and compositions for promoting tissue regeneration with adipose-derived stem cell side population cells are provided. The adipose-derived cells are administered in a tissue regenerating effect amount optionally with a bioactive agent. Additionally the adipose derived cells can be autologous or syngeneic.

Priority: US20040641034P Applic. Date: 2004-12-30

Inventor: SAYRE CHAUNCEY B [US]; SILVA FRANCISCO J [US]


Application No.: US20060147439A1  Published: 06/Jul/2006

Title: Agent and compositions comprising the same for inhibiting lipases and phospholipases in body fluids, cells and tissues

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD RELIANCE LIFE SCIENCE PVT. LTD

Application No.: 11/093637   Filing Date: 30/Mar/2005

Abstract:The present invention deals with a protein and compositions comprising the same for inhibition of lipases and phospholipases in the body fluids, cells, and tissues for the prevention and treatment of metabolic syndrome, cardiovascular disorders, and inflammatory diseases. The protein is either isolated from plant species or synthesized or produced by recombinant DNA technology.

Priority: US20040557624P Applic. Date: 2004-03-30

Inventor: UPADHYAY SHAKTI N [IN]; YADAV RAMAN P [IN]; ANSARI ARIF [IN]; RAO S HARINARAYANA [IN]


Application No.: US20060147508A1  Published: 06/Jul/2006

Title: Concurrent Enhancement of Skin Penetration of Organic Base Active Agents and Organic Hydroxy Acid Active Agents as Their Ion-Pair Complexes

Applicant/Assignee: BIODERM RESEARCH

Application No.: 11/307729   Filing Date: 18/Feb/2006

Abstract:This invention relates to concurrent enhancement of skin penetration of certain organic nitrogen heterocyclic base active agents and certain organic acid active agents, especially organic hydroxy acids. This concurrent enhancement of skin penetration also provides enhanced bioavailability of both organic nitrogen heterocyclic base active agent and organic hydroxy acid active agent. The organic nitrogen heterocyclic base active agents and organic hydroxy acid active agents are first combined to form an ion-pair complex, which includes an in-situ mixing process, and said ion-pair complex is applied topically, whereupon said ion-pair complex undergoes enhanced skin penetration and upon reaching uppermost living part of skin and having reached therein the physiological pH of 7.4, said ion-pair complex dissociates to release its constituent organic nitrogen heterocyclic base active agent and said organic acid active agent in a bioavailable form.

Priority: US2002-265000 Applic. Date: 2002-10-04; US2002-290933 Applic. Date: 2002-11-07; US2002-280519 Applic. Date: 2002-10-25; US2003-439349 Applic. Date: 2003-05-15; US2003-394851 Applic. Date: 2003-03-22

Inventor: GUPTA SHYAM K [US]


Application No.: US20060147510A1  Published: 06/Jul/2006

Title: Method for treating non-neuropathic pain

Applicant/Assignee: ENDO PHARMACEUTICALS, INC

Application No.: 11/336001   Filing Date: 20/Jan/2006

Abstract:A method including topically administering an effective amount of local anesthetic to a patient is disclosed. The method is effective for inducing analgesia for treating non-neuropathic pain. Non-neuropathic pain suitable for treatment according to the invention includes pain associated with sports injuries

sprains

strains

soft-tissue injury

repetitive motion injury

carpal tunnel syndrome

injury to tendons, ligament, and muscles

conditions such as fibromyalgia, bursitis, castrochondritis, myofascial pain, and pain associated with arthritis, inflammation, contusions, post-surgical pain, and nociceptive pain. Preferably, the lidocaine is applied via a transdermal patch applied near the locus of pain.

Priority: US2001-045341 Applic. Date: 2001-10-25

Inventor: GALER BRADLEY S [US]


Application No.: US20060148716A1  Published: 06/Jul/2006

Title: Peptidic sulfonamides

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 10/544625   Filing Date: 05/Aug/2005

Abstract:The invention relates to novel peptides which are biologically active as ligands of blood platelet integrin GPIIbIIIa and the alphav integrins, preferably the alphavbetas and alphavbeta3 integrin, having the formula (I): R<1>-Arg-X-Asp-Leu-Asp-Ser-Leu-Arg-R<2 >(I), in which R<1 >denotes H, acetyl or acyl and R<2 >denotes -Oh, OR<3 >NH2,NHR<3>, N(R<3>)2 R<3 >denotes atkyl, aralkyl, aryl, Het and X denotes an amino acid of the formula (II), in which A denotes (CH2)n R<4 >denotes H, alkyl, aralkyl or aryl, and n denotes 1, 2, 3, 4, 5 or 6, and the amino acid of the formula (II) is bonded to the adjacent Arg via a peptide bond of the alpha-amino group and to the alpha-amino group of the adjacent Asp via a peptide bond of the alpha-carboxyl group.

Priority: EP20030002556 Applic. Date: 2003-02-06; WO2004EP00211 Applic. Date: 2004-01-14

Inventor: JONCZYK ALFRED [DE]; GROTH ULRICH [DE]; ZISCHINSKY GUNTHER [DE]


Application No.: US20060148883A1  Published: 06/Jul/2006

Title: Medicaments for the Treatment or Prevention of Fibrotic Diseases

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/275226   Filing Date: 20/Dec/2005

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030769 Applic. Date: 2004-12-24

Inventor: PARK JOHN E [DE]; CHAUDHARY NVEED [DE]; ROTH GERALD J [DE]; HECKEL ARMIN [DE]; LEHMANN-LINTZ THORSTEN [DE]; KLEY JOERG [DE]


Application No.: US20060148903A1  Published: 06/Jul/2006

Title: Capsaicinoid gel formulation and uses thereof

Applicant/Assignee: ALGORX PHARMACEUTICALS, INC

Application No.: 11/286059   Filing Date: 23/Nov/2005

Abstract:The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 mug to 10,000 mug.

Priority: US20040630577P Applic. Date: 2004-11-24

Inventor: BURCH RONALD M [US]; ANDERSON TIMOTHY A [US]; LAZAR JEFF [US]


Application No.: US20060153788A1  Published: 13/Jul/2006

Title: Enhanced efficacy antiperspirant active

Applicant/Assignee:

Application No.: 11/034477   Filing Date: 13/Jan/2005

Abstract:An enhanced efficacy aluminum only salt active. The method for making such active comprises the steps of (a) providing an aqueous solution of an aluminum salt having a Band III polymer concentration of at least about 20%

(b) adding to the aqueous solution of step (a) an aqueous solution of a monomeric aluminum salt to form a mixture

and (c) rapidly drying the mixture to form a product powder. The active comprises an aluminum only salt having a Band III polymer concentration of at least about 20%, an aluminum to anion ratio of from about 1.1:1 to about 1.8:1 and a level of monomeric aluminum of from about 2% to about 20% of the total aluminum.

Priority:

Inventor: SWAILE DAVID F [US]; BEIMESCH WAYNE E [US]; GOOD DAVID [US]; SMITH SCOTT E [US]


Application No.: US20060153791A1  Published: 13/Jul/2006

Title: Repeat sequence protein polymer active agent congjugates, methods and uses

Applicant/Assignee: GENENCOR INTERNATIONAL, INC

Application No.: 11/351712   Filing Date: 10/Feb/2006

Abstract:Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.

Priority: US2004-845936 Applic. Date: 2004-05-14; US20030470464P Applic. Date: 2003-05-14

Inventor: COLLIER KATHERINE D [US]; CUEVAS WILLIAM A [US]; KUMAR MANOJ [US]


Application No.: US20060153792A1  Published: 13/Jul/2006

Title: Novel cosmetic formulations based on a gel-forming and/or thickening agent and applications of same

Applicant/Assignee:

Application No.: 10/530082   Filing Date: 08/Dec/2005

Abstract:The invention relates to the field of the necessities of life and more particularly to the field of cosmetics, hygiene and skin products. More specifically it relates to aqueous, fluid or gelled, cosmetic compositions intended to be applied to the skin, the mucous membranes or the teguments, characterized in that they contain, as active ingredient, a gelling and/or thickening agent formed from a combination of three constituents, namely a polyacrylamide and ammonium acrylate copolymer and/or an anionic acrylic copolymer, lecithins or phospholipids of plant origin, and a polyglyceryl acylate, in combination or in a mixture with excipients or appropriate vehicles for topical use. These compositions can incorporate other appropriate active ingredients in particular for use in cosmetics. Use in cosmetics or in skin products for the production of perfectly stable emulsions, gels, or creams.

Priority: FR20020012202 Applic. Date: 2002-10-02; WO2003FR02898 Applic. Date: 2003-10-02

Inventor: ARNAUD JEAN-PIERRE [FR]; LE FUR AGNES [FR]


Application No.: US20060153793A1  Published: 13/Jul/2006

Title: Aqueous polymer dispersion and use thereof in cosmetics

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 10/564485   Filing Date: 13/Jul/2004

Abstract:The present invention relates to an aqueous polymer dispersion which is obtainable by free-radical polymerization of a monomer mixture which comprises at least one amide-group-containing compound, at least one crosslinker and at least one monomer with at least one cationogenic and/or cationic group. The invention further relates to the polymers obtainable by drying such a polymer dispersion, and to cosmetic or pharmaceutical compositions which comprise such a polymer dispersion or such a polymer.

Priority: DE20031031865 Applic. Date: 2003-07-14; WO2004EP07741 Applic. Date: 2004-07-13

Inventor: CHRISSTOFFELS LYSANDER [US]


Application No.: US20060153808A1  Published: 13/Jul/2006

Title: Cancer immunotherapy incorporating p53

Applicant/Assignee: INTROGEN THERAPEUTICS, INC

Application No.: 11/281922   Filing Date: 17/Nov/2005

Abstract:A method of stimulating an immune response to a tumor in an immunocompetent subject by administering a p53 expression construct to a tumor. The construct expresses p53 in tumor cells in an amount sufficient to stimulate an immune response against the tumor. Both viral and non-viral delivery systems are contemplated. The method can be combined with chemotherapy agents as well as with other cancer therapies.

Priority: US20040628990P Applic. Date: 2004-11-17

Inventor: CRISTOFANILLI MASSIMO [US]; KRISHNAMURTHY SAVITRI [US]; MENANDER KERSTIN [US]; HORTOBAGYI GABRIEL N [US]


Application No.: US20060153886A1  Published: 13/Jul/2006

Title: Ambiphilic porous matrix

Applicant/Assignee: PHARES PHARMACEUTICAL RESEARCH N.V

Application No.: 10/547193   Filing Date: 27/Feb/2004

Abstract:Compositions are described which are capable of forming external reservoirs comprising a polymeric matrix for adsorbing sebum in exchange for beneficial oils and transfer of hydrating components to the skin. The compositions may be lotions, creams, gels, pastes, lip sticks and water and oil systems. There is also described a method of preparing said lotions, creams, etc containing an ambiphilic powder mixture or complex comprising synthetic porous agglomerates, a lipophilic component, hydrophilioc attractant/polymer, optionally biologically active compound and excipients.

Priority: EP20030251212 Applic. Date: 2003-02-27; WO2004EP01985 Applic. Date: 2004-02-27

Inventor: LEIGH MATHEW L S [CH]; LEIGH STEVE [NL]; KUNG ELSA [CH]; VAN HOOGEVEST PETER [CH]


Application No.: US20060153889A1  Published: 13/Jul/2006

Title: Discontinuous surface coating for particles

Applicant/Assignee:

Application No.: 11/324943   Filing Date: 04/Jan/2006

Abstract:The present invention relates to particle compositions comprising a core particle that is partially coated with a first hydrophilic deposit and a hydrophobic polymeric finish, contains a small amount of water, and a compatible active present in the deposit, the finish or both. Additional alternating deposits, hydrophobic, hydrophilic or both, can be present between the first hydrophilic deposit and the hydrophobic polymeric finish. Similarly, additional compatible actives can be present in one or more of the additional alternating deposits. The invention also relates to methods of preparing the particle compositions.

Priority: US20050642721P Applic. Date: 2005-01-10

Inventor: FRIEL FRANCIS M [US]; LEE WILSON A [US]; SHIDARA AYA [US]; MERCADO CLARA G [US]; LEAVER ERIC J [US]


Application No.: US20060153891A1  Published: 13/Jul/2006

Title: Meta-stable insect repellent emulsion composition and method of use

Applicant/Assignee:

Application No.: 11/371582   Filing Date: 09/Mar/2006

Abstract:There is provided an improved insect repellent emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has an insect repellent active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from being bitten by insects in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a insect repellent emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free insect repellent composition.

Priority: US2002-334171 Applic. Date: 2002-12-30; US2001-032847 Applic. Date: 2001-12-26

Inventor: GONZALEZ ANTHONY D [US]; PECHKO ANDREW H [US]; POLYWODA VINCENT T [US]


Application No.: US20060153926A1  Published: 13/Jul/2006

Title: Compositions, products and methods for controlling weight in a mammal

Applicant/Assignee:

Application No.: 11/032341   Filing Date: 10/Jan/2005

Abstract:Compositions for controlling mammalian weight, said compositions comprising one or more lipolytic agents for stimulating mammalian lipolysis and/or thermogenic agents for modulating mammalian thermogenesis. Products, consumer and otherwise, comprising said compositions and methods of using both the present compositions and products to control mammalian weight.

Priority:

Inventor: BASCOM CHARLES C [US]; YOUNGQUIST ROBERT S [US]; WALANSKI AMY A [US]; HO BEGONIA Y [US]; FUENTES GARY R [US]


Application No.: US20060154834A1  Published: 13/Jul/2006

Title: Products comprising an applicator and lipid and aqueous phase

Applicant/Assignee:

Application No.: 10/521070   Filing Date: 08/Jul/2003

Abstract:This invention concerns products for cleansing and other applications, which products comprise an applicator such as a puff (pouf), pad, sponge, cotton ball, swab, brush glove, mitt or bar, to which a lipid and aqueous phase have been applied. The invention further concerns the manufacture and use of such products.

Priority: WO2003EP07397 Applic. Date: 2003-07-08

Inventor: HAUSER MATTHIAS [DE]; ANSMANN ACHIM [DE]; ISSBERNER ULRICH [DE]; JACKWERTH BETTINA [DE]; LEONARD MARK [GB]


Application No.: US20060154852A1  Published: 13/Jul/2006

Title: Beta sheet tapes ribbons in tissue engineering

Applicant/Assignee: UNIVERSITY OF LEEDS

Application No.: 10/521628   Filing Date: 08/Sep/2005

Abstract:There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.

Priority: GB20020016286 Applic. Date: 2002-07-15; WO2003GB03016 Applic. Date: 2003-07-15

Inventor: BODEN NEVILLE [GB]; AGGELI AMALIA [GB]; INGHAM EILEEN [GB]; KIRKHAM JENNIFER [GB]


Application No.: US20060154939A1  Published: 13/Jul/2006

Title: Medicaments for the Treatment or Prevention of Fibrotic Diseases

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/275225   Filing Date: 20/Dec/2005

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1 , the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030768 Applic. Date: 2004-12-24

Inventor: PARK JOHN E [DE]; CHAUDHARY NVEED [DE]; LEHMANN-LINTZ THORSTEN [DE]; HECKEL ARMIN [DE]; ROTH GERALD J [DE]; KLEY JOERG [DE]; BRANDL TRIXI [DE]; DAHMANN GEORG [DE]; GRAUERT MATTHIAS [DE]


Application No.: US20060154947A1  Published: 13/Jul/2006

Title: Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in manufacture of medicaments

Applicant/Assignee:

Application No.: 10/549433   Filing Date: 17/Oct/2005

Abstract:The invention relates to alkaloid reaction products obtainable in a process wherein alkaloids are reacted with an alkylating agent, preferably thiotepa, whereafter unreacted alkylating agent and other water-soluble compounds are removed from the reaction mixture by washing with water or a suitable aqueous solvent, whereafter the reaction mixture is subjected to a treatment with strong acid, preferably hydrogen chloride (HCI), to precipitate a water soluble salt of the reaction products. The precipitated reaction products comprise at least one quaternary alkaloid derivative and are suitable as drugs for prophylactic or therapeutic application, particularly in the treatment of immunological or metabolic dysfunctions, and cancer.

Priority: EP20030006015 Applic. Date: 2003-03-18; WO2004EP02637 Applic. Date: 2004-03-12

Inventor: NOWICKY WASSYL [AT]


Application No.: US20060155113A1  Published: 13/Jul/2006

Title: Replication protein

Applicant/Assignee: CIZZLE BIOTECHNOLOGY LIMITED

Application No.: 10/537228   Filing Date: 13/Jan/2006

Abstract:This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer.

Priority: GB20020028337 Applic. Date: 2002-12-05; US20020433925P Applic. Date: 2002-12-17; WO2003GB05334 Applic. Date: 2003-12-05

Inventor: COVERLEY DAWN [GB]


Application No.: US20060159626A1  Published: 20/Jul/2006

Title: Method for administering a cytokine to the central nervous system and the lymphatic system

Applicant/Assignee:

Application No.: 11/222669   Filing Date: 09/Sep/2005

Abstract:The present invention is directed to a method for delivering cytokines to the central nervous system and the lymphatic system by way of a tissue innervated by the trigeminal nerve and/or olfactory nerve. Cytokines include tumor necrosis factors, interleukins, interferons, particularly interferon-beta and its muteins such as IFN-betaser17. Such a method of delivery can be useful in the treatment of central nervous system disorders, brain disorders, proliferative, viral, and/or autoimmune disorders such as Sjogren's disorder.

Priority: US2002-102163 Applic. Date: 2002-03-20; US2000-733168 Applic. Date: 2000-12-08; US19990200708P Applic. Date: 1999-12-09

Inventor: FREY WILLIAM H II [US]


Application No.: US20060159638A1  Published: 20/Jul/2006

Title: O/W emulsions comprising micronized biologically active agents

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/378483   Filing Date: 20/Mar/2006

Abstract:Topically applicable cosmetic/pharmaceutical oil-in-water emulsions, well suited for treating or caring for the skin and/or superficial body growths therefrom, include a discontinuous fatty phase dispersed in a continuous aqueous phase and comprise an effective amount of at least one biologically active agent (A) and an effective amount of an emulsifying system (B) therefor, the at least one biologically active agent (A) being non-solubilized therein in micronized particulate state, at least 80%, numerically, of the micronized particles having diameters ranging from 1 to 10 mum and at least 50%, also numerically, having diameters of less than 5 mum.

Priority: FR19980016050 Applic. Date: 1998-12-18; US2001-881686 Applic. Date: 2001-06-18; WO1999FR03136 Applic. Date: 1999-12-14

Inventor: SEGURA SANDRINE [FR]; PREUILH ISABELLE [FR]


Application No.: US20060159714A1  Published: 20/Jul/2006

Title: Use of an antioxidant in a dermatological and/or cosmetic composition

Applicant/Assignee:

Application No.: 10/562443   Filing Date: 07/Jul/2004

Abstract:The invention relates to a dermatological and/or cosmetic composition which is intended for the treatment of acne, seborrheic dermatitis and skin disorders associated with the formation of comedones. The invention is characterised in that it contains: as active principle, at least one lipophilic antioxidant which is selected from the group comprising gallates, flavonoids, butyl-hydroxytoluene (BHT), butyl-hydroxyanisole (BHA), octadecenedioic acid and hydroxydecanoic acid

and at least one second active principle in the form of a hydrophilic antioxidant selected from the group comprising mannitol, vitamin C, lysine azelate, rutin and quercetin.

Priority: FR20030008288 Applic. Date: 2003-07-07; WO2004FR01768 Applic. Date: 2004-07-07

Inventor: THOREL JEAN-NOEL [FR]


Application No.: US20060159715A1  Published: 20/Jul/2006

Title: Conjugate of fine porous particles with polymer molecules and the utilization thereof

Applicant/Assignee:

Application No.: 10/563816   Filing Date: 09/Jul/2004

Abstract:A conjugate which comprises fine porous particles (on which functional substance may be adhered) and a polymer based on water-soluble high molecular chain segment, and the use of the conjugate (for the purpose of stably supporting, or slowly releasing, a physiologically active substance, or the like).

Priority: JP20030293242 Applic. Date: 2003-07-09; WO2004JP10162 Applic. Date: 2004-07-09

Inventor: NAGASAKI YUKIO [JP]; TAKAHASHI TADAHITO [JP]; KATAOKA KAZUNORI [JP]; YAMADA YOSHIAKI [JP]


Application No.: US20060159716A1  Published: 20/Jul/2006

Title: Cosmetic emulsion comprising solid particles, method for preparing cosmetic emulsion, and method of using cosmetic emulsion

Applicant/Assignee:

Application No.: 11/305145   Filing Date: 19/Dec/2005

Abstract:The present disclosure relates to a cosmetic composition for making up or caring for the skin in the form of an emulsion comprising an aqueous phase and an oily phase, comprising a dispersion of wax particles with a mean size by volume of less than or equal to 1 mum in the aqueous phase and, dispersed in the oily phase, particles with a mean size by volume of less than or equal to 15 mum. This present disclosure further relates to a process for treating skin with the compositions described herein.

Priority: FR20040053045 Applic. Date: 2004-12-17; US20040638120P Applic. Date: 2004-12-23

Inventor: THEMENS AGNES [FR]; ARNAUD PASCAL [FR]


Application No.: US20060159730A1  Published: 20/Jul/2006

Title: Cosmetic or dermatological article comprising a medium that is soluble in water

Applicant/Assignee: L'OREAL

Application No.: 11/303961   Filing Date: 27/Mar/2006

Abstract:A cosmetic or dermatological article may include: a medium in the form of at least one sheet of a material that is soluble in water at a temperature lower than 20 DEG C.

and at least one cosmetic or dermatological compound carried by the medium.

Priority: FR20050050014 Applic. Date: 2005-01-03; US20050658165P Applic. Date: 2005-03-04

Inventor: SIMON PASCAL [FR]


Application No.: US20060159924A1  Published: 20/Jul/2006

Title: Dry Products Comprising an Applicator and Two Phases

Applicant/Assignee:

Application No.: 10/520952   Filing Date: 08/Jul/2003

Abstract:This invention concerns products for cleansing and other applications, which products comprise an applicator such as a puff (pouf), pad, sponge, cotton ball, swab, brush, glove, mitt or bar, to which a lipid and aqueous phase have been applied and which products have been dried afterwards. The invention further concerns the manufacture and use of such products.

Priority: EP20020077873 Applic. Date: 2002-07-12; EP20030075198 Applic. Date: 2003-01-13; WO2003EP07396 Applic. Date: 2003-07-08

Inventor: HAUSER MATTHIAS [DE]; ISSBERNER ULRICH [DE]; ANNSMANN ACHIM [DE]; JACKWERTH BETTINA [DE]; LEONARD MARK [US]


Application No.: US20060160702A1  Published: 20/Jul/2006

Title: Compositions comprising anti-proliferative agents and use thereof

Applicant/Assignee:

Application No.: 11/289156   Filing Date: 28/Nov/2005

Abstract:The invention relates to anti-proliferative agents derived from plants, wherein the agents are capable of inducing a plant organ into a state of dormancy or maintaining the organ in the state of dormancy. The invention further discloses compositions comprising the anti-proliferative agents and the use of said compositions to inhibit undesired or deleterious cell proliferation in plant or mammal tissue.

Priority: US2003-465911 Applic. Date: 2003-06-20; US2001-915768 Applic. Date: 2001-07-27; US1999-367898 Applic. Date: 1999-11-29; WO1998IL00085 Applic. Date: 1998-02-23

Inventor: SOUDANT ETIENNE [FR]; OPPEN-BEZALEL LEA V [DE]; ZIV MEIRA [IL]; PERRY INON [IL]


Application No.: US20060160718A1  Published: 20/Jul/2006

Title: Sprayable perfume with an improved tenacity

Applicant/Assignee:

Application No.: 11/266060   Filing Date: 02/Nov/2005

Abstract:An alcoholic perfume solution with an improved tenacity when applied onto a surface is described. The solution contains an effective amount of a single polymer capable of extending the diffusion of perfuming ingredients in the air.

Priority: EP20030010264 Applic. Date: 2003-05-07; WO2004IB01603 Applic. Date: 2004-05-03

Inventor: BEAUSSOUBRE PASCAL [FR]; STORA THIERRY [FR]


Application No.: US20060160719A1  Published: 20/Jul/2006

Title: Flavor and fragrance compositions

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 11/333367   Filing Date: 18/Jan/2006

Abstract:The present invention provides a flavor and fragrance composition which comprises, as the active ingredient, an optically active (1S)-8-mercaptomenthone having an S-form/R-form mixing ratio for the configuration at the 4-position in the range of from 65:35 to 95:5 by weight, wherein the flavor and fragrance composition is for use in food and beverage, fragrances and cosmetics, pharmaceuticals or oral compositions and the like

a product which is scented with the flavor and fragrance composition

and a method for enhancing or modulating odor of the flavor and fragrance composition by adding the optically active (1S)-8-mercaptomenthone.

Priority: JP20050009811 Applic. Date: 2005-01-18

Inventor: EMURA MAKOTO [JP]; MASUMURA SATOSHI [JP]; MARUYAMA KENJI [JP]; YAMAMOTO TAKESHI [JP]


Application No.: US20060160762A1  Published: 20/Jul/2006

Title: Methods for the treatment, diagnosis, and prognosis of cancer

Applicant/Assignee: CHILDREN'S MEDICAL CENTER CORPORATION

Application No.: 11/301592   Filing Date: 13/Dec/2005

Abstract:We have discovered that antizyme inhibitor (AZI) is expressed at increased levels in highly proliferating cells. We have also discovered that inhibiting antizyme inhibitor, including inhibiting its expression, reduces the growth of cancer cells. The present invention is directed to the use of inhibitors of antizyme inhibitor for the treatment of cancer, the use of antizyme inhibitor for the diagnosis and prognosis of cancer, and methods for identifying novel cancer treatments.

Priority: US20040635643P Applic. Date: 2004-12-13

Inventor: ZETTER BRUCE R [US]; KIM SONIA [US]; MANGOLD URSULA [US]


Application No.: US20060160876A1  Published: 20/Jul/2006

Title: Indole derivatives

Applicant/Assignee: SALMEDIX, INC CEPHALON, INC

Application No.: 10/957039   Filing Date: 01/Oct/2004

Abstract:Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Priority: US20030508592P Applic. Date: 2003-10-02; US20040556599P Applic. Date: 2004-03-26

Inventor: CHAO QI [US]; ELLIOTT GARY T [US]; LEONI LORENZO [CH]; PHILLIPS MIMI K [US]


Application No.: US20060160894A1  Published: 20/Jul/2006

Title: Benzamides as ppar modulators

Applicant/Assignee: LABORATORIOS S.A.L.V.A.T.,S.A

Application No.: 10/560533   Filing Date: 13/Dec/2005

Abstract:Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position

-A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical

-W is an N- and C-linked biradical selected from several possibilities

and -Z is a carbon radical selected from several possibilities. These compounds are PPARgamma and PPARgamma/PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.

Priority: ES20030001461 Applic. Date: 2003-06-13; WO2004EP06330 Applic. Date: 2004-06-11

Inventor: FERNANDEZ SERRAT ANNA [ES]; SERRA COMAS CARMEN [ES]; BALSA LOPEZ DOLORS [ES]; LLEBARIA SOLDEVILA AMADEU [ES]; FARRERONS GALLEMI CARLES [ES]; MIQUEL BONO IGNACIO J [ES]; CATENA JUAN L [ES]; LAGUNAS ARNAL CARMEN [ES]; CORDOMI MONTOYA ARNAU [ES]; SALCEDO ROCA CAROLINA [ES]; TOLEDO MESA NATIVIDAD [ES]; MARRERO GONZALEZ PEDRO [ES]; HARO BAUTISTA DIEGO [ES]; FERNANDEZ GARCIA ANDRES [ES]


Application No.: US20060160897A1  Published: 20/Jul/2006

Title: Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders

Applicant/Assignee:

Application No.: 11/275258   Filing Date: 21/Dec/2005

Abstract:The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre-malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.

Priority: EP20030014278 Applic. Date: 2003-06-25; WO2004EP06789 Applic. Date: 2004-06-23

Inventor: PELICCI PIER G [IT]; CHIMENTI SERGIO [IT]; COSTANZO ANTONIO [IT]; NISTICO STEVEN P [IT]; PAOLINO DONATELLA [IT]; MINUCCI SAVERIO [IT]


Application No.: US20060161132A1  Published: 20/Jul/2006

Title: Dosage control electrode for iontophoresis device

Applicant/Assignee: TRAVANTI PHARMA INC

Application No.: 10/545761   Filing Date: 15/Aug/2005

Abstract:An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed

the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.

Priority: US2003-371532 Applic. Date: 2003-02-21; WO2003US31373 Applic. Date: 2003-10-02

Inventor: ANDERSON CARTER R [US]; MORRIS RUSSELL L [US]


Application No.: US20060161142A1  Published: 20/Jul/2006

Title: Multiple wavelength laser workstation

Applicant/Assignee: CYNOSURE, INC

Application No.: 11/035680   Filing Date: 14/Jan/2005

Abstract:Lasers capable of lasing at at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium.

Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized.

In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy.

Priority:

Inventor: SIERRA RAFAEL A [US]; KOSCHMANN ERIC C [US]; DAY JOSEPH M [US]; SHERR EVAN A [US]; BOLL JAMES H [US]


Application No.: US20060165619A1  Published: 27/Jul/2006

Title: Cosmetic composition for skin whitening comprising senkyunolide A as active ingredient

Applicant/Assignee: COREANA COSMETICS CO., LTD

Application No.: 11/389284   Filing Date: 27/Mar/2006

Abstract:The present invention relates to cosmetic compositions and more particularly to skin-whitening cosmetic compositions comprising senkyunolide A as an active ingredient. The present invention discloses the novel inhibitory function of senkyunolide A isolated from Cnidium officinale and Ligusticum chuanxiong on the melanocyte-stimulating hormone (MSH), and provides MSH-inhibitory compositions and skin-whitening cosmetic compositions comprising the senkyunolide A. The compositions of the present invention show significantly enhanced skin-whitening effect owing to its efficient inhibition of MSH even in lower concentration.

Priority: KR20020066050 Applic. Date: 2002-10-29; US2003-353010 Applic. Date: 2003-01-29

Inventor: LEE KANG-TAE [KR]; LEE JUNG-NO [KR]; JEONG JEE-HEAN [KR]; LEE YOUNG-JIN [KR]; LEE SEUNG-JI [KR]


Application No.: US20060165623A1  Published: 27/Jul/2006

Title: Natural deodorant composition

Applicant/Assignee: TERRA FIRMA NATUALS, INC

Application No.: 11/042569   Filing Date: 24/Jan/2005

Abstract:The present invention relates to a natural deodorant system and a natural system for topical and systemic delivery of active ingredients, both systems being primarily free of, preferably substantially free of, more preferably essentially free of, and most preferably completely free of ethoxylates or other petrochemical derivatives, and comprising: (a) at least one of (1) glycerine (preferably of plant origin), (2) a polyol selected from the group consisting of galactitol, erythritol, inositol, ribitol, dithioerythritol, dithiothreitol, (3) a sugar alcohol, selected from the group consisting of mannitol, sorbitol, xylitol and maltitol, (4) a hydrogenated starch hydrosylates of at least one of berries, apples or plums, and (5) mixtures thereof

(b) water or a lower monohydric alcohol, selected from the group of methanol, ethanol, propanol and isoproponal, or mixtures thereof, present at a combined concentration of at least 20%

(c) one or more carrageenans (preferably of plant origin) or alginates, or mixtures thereof, present in combined concentrations of less than about 2%

and (d) optionally, one or more thickeners or gums selected from the group consisting of tara, guar, xanthan, Arabic, tragacanth, agar, locust bean gum, ghatti and microcrystalline celluloses.

Priority:

Inventor: WORKMAN TANYA [CA]; RATNIKOVA SVETLANA [CA]


Application No.: US20060165630A1  Published: 27/Jul/2006

Title: Use of amide or ester of sugar and of fatty acid, for treating and/or preventing dry skin

Applicant/Assignee:

Application No.: 10/527311   Filing Date: 08/Aug/2005

Abstract:The present invention relates to the use of at least one amide, a mono- or polyester of suger and of fatty acid, especially linoleic acid, for the preparation of a cosmetic of pharmaceutical composition intented for treating and/or preventing dry skin. It also relates to the use of at least one amide, a sugar mono- or polyester of fatty acid, for the preparation of a cosmetic composition intented for treating oligoseborrhoeic dry skin and/or for stimulating sebum production. It also relates to the use of at least one amide, a mono- or polyester of sugar of linoleic acid for the preparation of a cosmetic or pharmaceutical composition, intented for generating 13-hydroxy-octadecadienoic acid and/or for treating and/or preventing skin disorders and/or disorders of the pilosebaceous unit associated with a deficit of linoleic acid.

Priority: FR20020012827 Applic. Date: 2002-10-15; FR20020012828 Applic. Date: 2002-10-15; WO2003IB04517 Applic. Date: 2003-10-14

Inventor: RUBINSTENN GILLES [FR]; MICHELET JEAN-FRANCOIS [FR]; BERNARD BRUNO [FR]; DALKO MARIA [FR]


Application No.: US20060165632A1  Published: 27/Jul/2006

Title: Use of carbohydrates to improve skin barrier function

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 11/200243   Filing Date: 10/Aug/2005

Abstract:The present invention concerns compositions containing carbohydrate derivatives for enhancing the skin barrier function. The invention further concerns a cosmetic treatment method for enhancing the skin barrier function by applying on the skin compositions comprising carbohydrate derivatives.

Priority: FR20000014557 Applic. Date: 2000-11-13; US2003-436155 Applic. Date: 2003-05-13; WO2001FR03550 Applic. Date: 2001-11-13

Inventor: MEHUL BRUNO [FR]


Application No.: US20060165637A1  Published: 27/Jul/2006

Title: Topical agent containing phytanic acid or a derivative thereof

Applicant/Assignee:

Application No.: 10/559625   Filing Date: 06/Dec/2005

Abstract:The invention relates to agents for topical administration of a compound of formula (I): (CH3)2CH-(CH2)3-CH(CH3)-(CH2)3-CH(CH3)-(CH2)3-C(A)(CH3)-C(B)2-C(O)-R, wherein R represents hydrogen, OR<1>, N(OH)R<1 >or NR<2>R<3>

R<1>, R<2 >and R<3 >independently represent hydrogen C1-C22-alkyl, C1-C22-alkenyl, C7-C12-arylalkyl (particularly benzyl, phenethyl and phenylpropyl), retinyl, tocopheryl, ascorbyl or a radical stemming from an amino acid or a peptide and A and B represent hydrogen atoms or A and a radical B form a double bond and the other radical B represents a hydrogen atom or radical A represents a hydrogen atom and the radicals B together form an oxygen atom or one of the radicals B represents a hydroxyl group and the other radical B and radical A represent hydrogen atoms. Said agents contain a compound of formula (I) and a pharmaceutically and/or cosmetically acceptable carrier provided that the agent does not contain any retinoids.

Priority: EP20030013724 Applic. Date: 2003-06-17; WO2004EP06520 Applic. Date: 2004-06-17

Inventor: VOLLHARDT JURGEN H [CH]; BEUMER RAPHAEL [DE]


Application No.: US20060165643A1  Published: 27/Jul/2006

Title: Cosmetic or dermopharmaceutical compositions containing kombucha

Applicant/Assignee:

Application No.: 10/523333   Filing Date: 29/Aug/2005

Abstract:Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

Priority: FR20020009710 Applic. Date: 2002-07-30; WO2003FR02368 Applic. Date: 2003-07-25

Inventor: LINTNER KARL [FR]


Application No.: US20060165672A1  Published: 27/Jul/2006

Title: Fatigue reducing agent

Applicant/Assignee: KANEKA CORPORATION

Application No.: 10/541020   Filing Date: 28/Jun/2005

Abstract:To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

Priority: JP20030024758 Applic. Date: 2003-01-31; WO2004JP00366 Applic. Date: 2004-01-19

Inventor: FUJII KENJI [JP]; KAWABE TAIZO [JP]; HOSOE KAZUNORI [JP]; HIDAKA TAKAYOSHI [JP]


Application No.: US20060165708A1  Published: 27/Jul/2006

Title: Cancer vaccine containing cancer antigen based on tumor suppressor gene wt1 product and cationic liposomes

Applicant/Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA

Application No.: 10/482327   Filing Date: 29/Dec/2003

Abstract:A cancer vaccine comprising a cancer antigen which comprises, as an active ingredient, the product of a tumor suppressor gene WT1, a partial peptide or a modified version thereof, and a cationic liposome.

Priority: JP20010199449 Applic. Date: 2001-06-29; WO2002JP06597 Applic. Date: 2002-06-28

Inventor: MAYUMI TADANORI [JP]; SUGIYAMA HARUO [JP]; OHSUGI YOSHIYUKI [JP]


Application No.: US20060165739A1  Published: 27/Jul/2006

Title: Alcohol-free microemulsion composition

Applicant/Assignee: MARY KAY INC

Application No.: 11/325605   Filing Date: 03/Jan/2006

Abstract:The present invention concerns compositions that comprise alcohol-free microemulsions and methods for their use that include a surfactant, a lipophilic linker, and/or a hydrophilic linker. These compositions can be used, for example, in cosmetic or hair applications. In certain aspects, compositions of the invention have the ability to microemulsify sebum while providing enhanced cleansing of cosmetic products from the skin or hair. In addition, the compositions have the ability to enhance the penetration of skin or hair active ingredients, such as emollients, humectants, anti-oxidants, lipids, vitamins, botanicals, dyes, tanning compounds, etc.

Priority: US20050642217P Applic. Date: 2005-01-06; US20050667454P Applic. Date: 2005-04-01; US20050669089P Applic. Date: 2005-04-07

Inventor: KOMESVARAKUL NAPAPORN [US]; FALLER JAMES [US]; JONES BRIAN [US]; SCHILTZ JOHN [US]; SZEKERES ERIKA [US]; MENTLIK ANTON [US]; FISHER LOUIS [US]; NICOLL GREGG [US]; SABATINI DAVID [US]; SCAMEHORN JOHN [US]


Application No.: US20060165741A1  Published: 27/Jul/2006

Title: Low pH skin care compositions containing dehydroacetic acid

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/339282   Filing Date: 25/Jan/2006

Abstract:Stable skin care compositions comprising dehydroacetic acid and a dermatologically acceptable carrier. The dermatologically acceptable carrier comprises at least one oil, said oil having a solubility in water of about 5% or less and a solubility parameter of from about 7 to about 15, and the dehydroacetic acid is distributed primarily into said oil. The compositions have a pH of about 4.5 and below.

Priority: US20050647197P Applic. Date: 2005-01-26

Inventor: COFFINDAFFER TIMOTHY W [US]; HA ROBERT B K [US]; O'DONOGHUE MARGARET A [US]; ROBINSON LARRY R [US]


Application No.: US20060165744A1  Published: 27/Jul/2006

Title: Combination liposomal formulations

Applicant/Assignee: NEOPHARM, INC

Application No.: 10/558159   Filing Date: 22/May/2004

Abstract:The present invention provides a composition comprising a physiologically acceptable carrier and two or more agents encapsulated in a liposome, wherein the combination of the two or more agents possess the following properties: (1) cytotoxicity to tumor cells, (2) nutritional properties, (3) use in application to nails, hair, skin or lips or (4) activity against parasites and insects. The invention also provides a method of making such a composition. The invention further provides a method of treating cancer when the combination of the two or more agents is cytotoxic to tumor cells.

Priority: US20030472664P Applic. Date: 2003-05-22; US20030495260P Applic. Date: 2003-08-13; WO2004US16413 Applic. Date: 2004-05-22

Inventor: JAMIL HARIS [US]; AHMAD IMRAN [US]; AHMAD ZAFEER [US]; ANYARAMBHATLA GOPAL [US]


Application No.: US20060165823A1  Published: 27/Jul/2006

Title: Topical delivery agents and methods for making and using therm

Applicant/Assignee:

Application No.: 11/188129   Filing Date: 21/Jul/2005

Abstract:The invention provides methods for making and using topical delivery agents, wherein the delivery agents comprise an oil, e.g., jojoba oil, and an active agent, and formulations made by the methods of the invention.

Priority: WO2004US03558 Applic. Date: 2004-01-21; US20030441909P Applic. Date: 2003-01-21

Inventor: HERRERA HECTOR [US]


Application No.: US20060166925A1  Published: 27/Jul/2006

Title: Substitution derivatives of n6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds

Applicant/Assignee:

Application No.: 10/540993   Filing Date: 15/Aug/2005

Abstract:The invention concerns novel substitution derivatives of N<6>-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N<6>-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.

Priority: CZ20020004273 Applic. Date: 2002-12-30; WO2003CZ00078 Applic. Date: 2003-12-29

Inventor: DOLEZAL KAREL [CZ]; POPA IGOR [CZ]; ZATLOUKAL MAREK [CZ]; LENOBEL RENE [CZ]; HRADECKA DANA [CZ]; VOJTESEK BORIVOJ [CZ]; ULDRIJAN STJEPAN [CZ]; MLEJNEK PETR [CZ]; WERBROUCK STEFAAN [BE]; STRNAD MIROSLAV [CZ]


Application No.: US20060166949A1  Published: 27/Jul/2006

Title: Vitamin d analogues, compositions comprising said analogues and their use

Applicant/Assignee: LEO PHARMA A/S

Application No.: 10/532019   Filing Date: 25/Oct/2005

Abstract:Compounds according to formula I in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6)hydrocarbyl, optionally substituted with one or two hydroxyl group or one or more fluorine atoms, or, together with the carbon atom to which they are both attached, R1 and R2 form a (C3-C6)carbocyclic ring, or one of R1 and R2 taken together with R3 forms a direct bond, such that a triple bond is constituted, or R1 and R2 represent both hydrogen

R3 when not forming a direct bond with one of R1 and R2 represents hydrogen or (C1-C3)hydrocarbyl

X represents (E)-ethylene, (Z)-ethylene, ethynylene, or a bond

Y and Z independently represent hydrogen or methyl

the bond between C#16 and C#17 is depicted with a dotted line to illustrate that said bond may be either a single bond, in which case the projection of the ring substituent is beta, or a double bond

A represents hydroxyl, fluorine or hydrogen

B represents CH2 or H2

the configuration in the 3-position corresponds to the same configuration as in natural vitamin D3 (normal), or the configuration in the 3-position is opposite to that of natural vitamin D3 (epi)

with the proviso that when X represents (E)-ethylene or (Z)-ethylene, one of R1 and R2 taken together with R3 may not form a direct bond, such that a triple bond is constituted

with the further proviso that when X represents a bond R1 and R2 are not hydrogen

with the further proviso that the compound of formula I is not 3(S)-hydroxy-9,10-secocholesta-5(Z),7(E),10(19),22(E),24-penta-ene

and prodrugs and stereo isomeric forms thereof are provided together with their use in therapy, and their use in the manufacture of medicaments.

Priority: DK20020001608 Applic. Date: 2002-10-23; WO2003DK00718 Applic. Date: 2003-10-23

Inventor: BINDERUP ERNST T [DK]; KAI HOLST H [DK]; CLAUS AAGE SVENSGAARD B [DK]; MARTIN JOHN C [DK]


Application No.: US20060166978A1  Published: 27/Jul/2006

Title: Substituted beta carbolines

Applicant/Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH

Application No.: 11/390287   Filing Date: 28/Mar/2006

Abstract:The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of IkappaB kinase is involved.

Priority: EP20000105514 Applic. Date: 2000-03-15; EP20000125169 Applic. Date: 2000-11-18; US2003-627978 Applic. Date: 2003-07-28; US2001-812785 Applic. Date: 2001-03-15

Inventor: RITZELER OLAF [DE]; CASTRO ALFREDO [US]; GRENIER LOUIS [US]; SOUCY FRANCOIS [US]; HANCOCK WAYNE W [US]; MAZDIYASNI HORMOZ [US]; PALOMBELLA VITO [US]; ADAMS JULIAN [US]


Application No.: US20060166990A1  Published: 27/Jul/2006

Title: Novel aminobenzophenone compounds

Applicant/Assignee: LEO PHARMA A/S

Application No.: 10/563474   Filing Date: 09/Jul/2004

Abstract:The invention provides novel compounds according to formula I relates to compounds with the general formula I said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases or cancer.

Priority: US20030489488P Applic. Date: 2003-07-24; WO2004DK00490 Applic. Date: 2004-07-09

Inventor: OTTOSEN ERIK R [DK]; HORNEMAN ANNE M [DK]; LIANG XIFU [DK]; SCHOU SOREN C [DK]; HAVEZ SOPHIE E [DK]; SABROE THOMA P [DK]


Application No.: US20060171968A1  Published: 03/Aug/2006

Title: Method of preventive treatment of allergy by oromucosal administration of an allergy vaccine

Applicant/Assignee: ALK-ABELLO A/S

Application No.: 11/325451   Filing Date: 05/Jan/2006

Abstract:The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising a) administering an allergy vaccine containing the allergen as active substance to the subject via an oromucosal route, b) wherein the subject to be treated is unsensitised in the sense of exhibiting no lgE response specific to the allergen, c) wherein the subject to be treated is free of clinical symptoms of any allergy, and d) wherein the preventive treatment is aimed at preventing or reducing subsequent clinical symptoms of the allergy associated with the allergen.

Priority: DK20050000040 Applic. Date: 2005-01-07; US20050641729P Applic. Date: 2005-01-07

Inventor: BRIMNES JENS [DK]; KILDSGAARD JENS [DK]


Application No.: US20060171971A1  Published: 03/Aug/2006

Title: Composition for wet wipes containing a non-irritating skin health benefit ingredient and the process for making

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/048446   Filing Date: 01/Feb/2005

Abstract:An oil-in-water emulsion composition for wet-wipes delivering a particulate skin health benefit ingredient in the oil phase. A process for making an oil-in-water emulsion composition in which the oil phase is first made as a concentrate and then diluted in water.

Priority:

Inventor: MARSH RANDALL G [US]; SAWIN PHILIP A [US]; VEGA VICTOR N [US]


Application No.: US20060171974A1  Published: 03/Aug/2006

Title: Compounds, formulations, and methods for treating or preventing rosacea

Applicant/Assignee:

Application No.: 11/321093   Filing Date: 29/Dec/2005

Abstract:In methods, compounds, and topical formulations for treatment of rosacea incorporating compounds represented by the formulas below: wherein each of R1, R2, and R3 is independently hydrogen, hologen, alkyl, or alkoxy

each of R4 and R5 is independently hydrogen, alkyl, or alkoxy

and each of R6 and R7 is independently hydrogen, nitro, alkyl, or alkoxy

wherein each of A1, A3, and A4 is independently hydrogen or alkyl

and A2 is independently hydrogen or hydroxy

and wherein each of B1, B2, and B3 is independently hydrogen, hydroxy, or alkoxy

and each of B4 and B5 is independently hydrogen or alkyl, applying such compounds topically as sprays, mists, aerosols, solutions, lotions, gels, creams, ointments, pastes, unguents, emulsions, and suspensions to treat rosacea and its symptoms.

Priority: US2004-853585 Applic. Date: 2004-05-25; US20030473611P Applic. Date: 2003-05-27

Inventor: DEJOVIN JACK [US]; ROSSI THOMAS M [US]


Application No.: US20060171988A1  Published: 03/Aug/2006

Title: Method of treatment using foams as artificial lymph nodes

Applicant/Assignee:

Application No.: 11/045596   Filing Date: 28/Jan/2005

Abstract:The present invention relates to pharmaceutical compositions for the improved activation of cells of the immune system that comprise a biocompatible implantable and an active pharmaceutical ingredient to be integrated into said foam, wherein said composition specifically activates cells of the immune system. In one preferred embodiment, said active pharmaceutical ingredient is selected from endogenous antigens that are selected from tumor-associated antigens. Said foam material can be implanted into a subject in order to produce the pharmaceutical composition in situ. Preferably, said pharmaceutical composition can be present in the form of an artificial lymph node, wherein said artificial lymph node functions as a reservoir for cells of the immune system. The invention also relates to methods for improved immunotherapy, in particular cancer immunotherapy.

Priority:

Inventor: HILF NORBERT [DE]; PINOCY JUERGEN [DE]


Application No.: US20060172011A1  Published: 03/Aug/2006

Title: Medical treatment

Applicant/Assignee:

Application No.: 11/232404   Filing Date: 21/Sep/2005

Abstract:Provided is a particle capable of being inserted into or taken up by a cell comprising i) a polynucleotide coding for a modulator of Notch signalling

and ii) a polynucleotide coding for an antigen or antigenic determinant thereof. Methods for using the particles are also described.

Priority: GB20030006583 Applic. Date: 2003-03-21; GB20030006582 Applic. Date: 2003-03-21; GB20030006621 Applic. Date: 2003-03-22; GB20030006622 Applic. Date: 2003-03-22; GB20030006626 Applic. Date: 2003-03-22; GB20030006624 Applic. Date: 2003-03-22; GB20030006640 Applic. Date: 2003-03-22; GB20030006644 Applic. Date: 2003-03-22; GB20030006650 Applic. Date: 2003-03-22; GB20030006651 Applic. Date: 2003-03-22; GB20030006654 Applic. Date: 2003-03-22; WO2004GB01229 Applic. Date: 2004-03-22

Inventor: CHAMPION BRIAN R [GB]; RAGNO SILVIA [GB]


Application No.: US20060172955A1  Published: 03/Aug/2006

Title: Antibiotic/benzoyl peroxide dispenser

Applicant/Assignee:

Application No.: 11/395802   Filing Date: 31/Mar/2006

Abstract:Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Priority: US2002-121839 Applic. Date: 2002-04-12; US2000-734748 Applic. Date: 2000-12-12

Inventor: VISHNUPAD MOHAN [US]; VISHNUPAD NAOMI [US]


Application No.: US20060173020A1  Published: 03/Aug/2006

Title: 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives

Applicant/Assignee:

Application No.: 11/245314   Filing Date: 06/Oct/2005

Abstract:1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.

Priority: US20040617119P Applic. Date: 2004-10-08

Inventor: HUANG SHENLIN [US]; LIN RONGHUI [US]; CONNOLLY PETER J [US]; EMANUEL STUART L [US]; MIDDLETON STEVEN A [US]; GRUNINGER ROBERT H [US]; WETTER STEVEN K [US]


Application No.: US20060173025A1  Published: 03/Aug/2006

Title: 2-Substituted phenyl-5,7-dialkyl-3,7-dihydropyrrole [2,3-d]pyrimidine-4-one derivatives, the preparation and the pharmaceutical use thereof

Applicant/Assignee: YANGTZE RIVER PHARMACUETICAL (GROUP) CO., LTD TIANJIN NORTH PHARMA SCI-TECH CO., LTD

Application No.: 10/559516   Filing Date: 14/May/2004

Abstract:The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.

Priority: CN20031042399 Applic. Date: 2003-06-06; WO2004CN00487 Applic. Date: 2004-05-14

Inventor: WANG YONGFENG [CN]; ZHAO KEJUN [CN]


Application No.: US20060173043A1  Published: 03/Aug/2006

Title: Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same

Applicant/Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Application No.: 10/564653   Filing Date: 15/Jul/2004

Abstract:The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder,

cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

Priority: KR20030048153 Applic. Date: 2003-07-15; KR20030048154 Applic. Date: 2003-07-15; KR20040052714 Applic. Date: 2004-07-07; KR20040052715 Applic. Date: 2004-07-07; KR20040052718 Applic. Date: 2004-07-07; KR20040052716 Applic. Date: 2004-07-07; KR20040052713 Applic. Date: 2004-07-07; WO2004KR01764 Applic. Date: 2004-07-15

Inventor: HAN GYOON H [KR]; KIM HWAN M [KR]; PARK SONG K [KR]; LEE CHANG-WOO [KR]; HAN SANG B [KR]; LEE KI H [KR]; KHO YUNG H [KR]; YANG JIN H [KR]; PARK BUM W [KR]; LEE HYANG W [KR]; HAN JEUNG W [KR]; RYU DONG K [KR]; LEE JIN H [KR]; CHUN TAE G [KR]; KIM YONG K [KR]; LEE HEE Y [KR]; LEE BONG Y [KR]; KIM JEOM Y [KR]; KIM JI D [KR]; YU KYUNGA [KR]; KIM SUN Y [KR]


Application No.: US20060173076A1  Published: 03/Aug/2006

Title: Antibiotic/benzoyl peroxide dispenser

Applicant/Assignee:

Application No.: 11/395505   Filing Date: 31/Mar/2006

Abstract:Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Priority: US2002-121839 Applic. Date: 2002-04-12; US2000-734748 Applic. Date: 2000-12-12

Inventor: VISHNUPAD MOHAN [US]; VISHNUPAD NAOMI [US]


Application No.: US20060173111A1  Published: 03/Aug/2006

Title: Medical films and articles prepared from emulsion polymers

Applicant/Assignee: ROHM AND HAAS COMPANY

Application No.: 11/335721   Filing Date: 19/Jan/2006

Abstract:Protective film forming compositions useful as medical films and other related wound care and treatment articles, including liquid bandages are prepared from emulsion polymers, including a polymer blend including at least one hard emulsion polymer component and at least one soft emulsion polymer component, having the required dynamic storage modulus and mean Tg of the hard and soft polymer blend components.

Priority: US20050648234P Applic. Date: 2005-01-28

Inventor: KARPOWICZ RICHARD [US]; NAKATANI ALAN I [US]; RICE KATHERINE S [US]


Application No.: US20060177397A1  Published: 10/Aug/2006

Title: Self-tanning product comprising two components and means for artificially coloring the skin

Applicant/Assignee: L'OREAL

Application No.: 11/311691   Filing Date: 20/Dec/2005

Abstract:Self-tanning products for the skin, including compartmentalized kits therefor, comprise at least two components (A) and (B) comprising: a first component (A) containing, formulated into a cosmetically acceptable medium, at least one self-tanning agent, and a second component (B) containing, also formulated into a cosmetically acceptable medium, at least one hydroxyalkylurea of formula (I) in which R1, R2, R3 and R4 each independently represent a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical containing from 1 to 5 hydroxyl groups, at least one of the radicals R1-R4 representing a hydroxyalkyl group, or salt, solvate, or isomer thereof

the components (A) and (B) being present in the same composition or confined separately.

Priority: FR20040053080 Applic. Date: 2004-12-20; US20050646596P Applic. Date: 2005-01-26

Inventor: CANDAU DIDIER [FR]


Application No.: US20060177403A1  Published: 10/Aug/2006

Title: Cosmetic/dermatological compositions comprising a derivative of glucose and of vitamin

Applicant/Assignee: L'OREAL

Application No.: 11/349249   Filing Date: 08/Feb/2006

Abstract:Topically applicable cosmetic/dermatological compositions suited for improving the condition of human keratin fibers, notably human hair, especially for reducing or stopping loss and/or inducing and/or stimulating growth and/or density thereof, contain a thus effective amount of (a) at least one derivative of glucose and of vitamin F, solubilized in a topically applicable, physiologically acceptable medium therefor which includes (b) at least one nonionic surfactant having a hydrophilic/lipophilic balance (HLB) of greater than 10, (c) at least one C1-C4 alcohol and (d) water.

Priority: FR20050050363 Applic. Date: 2005-02-08; US20050672070P Applic. Date: 2005-04-18

Inventor: MEZURE PATRICIA [FR]; DUBIEF CLAUDE [FR]


Application No.: US20060177408A1  Published: 10/Aug/2006

Title: Skin external agents and drugs

Applicant/Assignee: KANEBO COSTMETICS INC KAO CORPORATION

Application No.: 11/400651   Filing Date: 07/Apr/2006

Abstract:The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein R<1 >represents a C1-4 alkylene group

R<2 >and R<3 >each represents a linear or branched C1-8 alkyl group

and n is an integer of 2 to 5.

Priority: JP20000093152 Applic. Date: 2000-03-30; JP20000323637 Applic. Date: 2000-10-24; JP20000341577 Applic. Date: 2000-11-09; US2002-169040 Applic. Date: 2002-06-21; WO2000JP08942 Applic. Date: 2000-12-15

Inventor: UCHIWA HIDEYO [JP]; HIROTSU SACHIYO [JP]; HARATAKE AKINORI [JP]; IKEMOTO TAKESHI [JP]; MATSUI JUNICHI [JP]; YAMAZAKI SHUNSUKE [JP]; YOSHIDA MASAKI [JP]; HAYASE MOTOI [JP]


Application No.: US20060177505A1  Published: 10/Aug/2006

Title: Cleaning composition in solid form

Applicant/Assignee: L'OREAL

Application No.: 11/336844   Filing Date: 23/Jan/2006

Abstract:Cleansing composition provided in solid form and containing, in an anhydrous medium, at least one active agent chosen from salicylic acid and its derivatives, at least one pulverulent foaming surfactant, and at least one water-soluble polymer, it being possible for the quantity of water-soluble polymer to be up to 10% of the total weight of the composition. The composition is preferably provided in powdered or tablet form and it may be incorporated into a sponge. The composition may be used in particular for cleansing greasy skin with a tendency towards acne.

Priority: FR20050050264 Applic. Date: 2005-01-31; US20050661903P Applic. Date: 2005-03-16

Inventor: CALDUK AGNES [FR]


Application No.: US20060178340A1  Published: 10/Aug/2006

Title: Composition comprising soluble glucan oligomer from saccharomyces cerevisiae is2 for immune activation or prevention and treatment of cancer and the preparation method thereof

Applicant/Assignee:

Application No.: 10/549016   Filing Date: 14/Sep/2005

Abstract:The present invention relates to the soluble glucan oligomer having a M.W. ranging from 1,000 to 10,000 prepared by treating insoluble beta-glucan isolated the cell wall of yeast variant IS2 with commercially available beta-glucan hydrolyzing enzymes. The soluble glucan oligomer showed potent efficacy on promoting immune activity and on inhibiting the growth of cancer cell, therefore, it can be used as the therapeutics or health care food for treating and preventing immunodeficiency and cancer disease.

Priority: KR20030016665 Applic. Date: 2003-03-18; WO2004KR00584 Applic. Date: 2004-03-17

Inventor: CHUNG BONG-HYUN [KR]


Application No.: US20060178366A1  Published: 10/Aug/2006

Title: Compounds for the treatment of inflammatory disorders

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/291595   Filing Date: 01/Dec/2005

Abstract:This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-alpha or combinations thereof.

Priority: US2005-142601 Applic. Date: 2005-06-01; US20040576153P Applic. Date: 2004-06-02

Inventor: SIDDIQUI M A [US]; MANSOOR UMAR F [US]; REDDY PANDURANGA A [US]; MADISON VINCENT S [US]


Application No.: US20060178408A1  Published: 10/Aug/2006

Title: Nicotinamide derivatives useful as pde4 inhibitors

Applicant/Assignee:

Application No.: 10/564694   Filing Date: 13/Jul/2004

Abstract:This invention relates to nicotinamide derivatives of general formula (I): in which R<1>, Z and R<2 >have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Priority: GB20030017498 Applic. Date: 2003-07-25; WO2004IB02367 Applic. Date: 2004-07-13

Inventor: BARBER CHRISTOPHER G [GB]; BUNNAGE MARK E [GB]; HARVEY JOHN W [GB]; MATHIAS JOHN P [GB]


Application No.: US20060178504A1  Published: 10/Aug/2006

Title: Eotaxin: eosinophil chemotactic cytokine

Applicant/Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITED

Application No.: 11/362154   Filing Date: 27/Feb/2006

Abstract:A chemoattractant protein called "eotaxin" is capable of attracting eosinophils and of inducing eosinophil accumulation and/or activation in vitro and in vivo. Various types of agents that inhibit or otherwise hinder the production, release or activity of eotaxin may be used therapeutically in the treatment of asthma and other inflammatory diseases.

Priority: GB19930018984 Applic. Date: 1993-09-14; GB19940008602 Applic. Date: 1994-04-29; US2003-622134 Applic. Date: 2003-07-18; US1999-291038 Applic. Date: 1999-04-14; US1996-615232 Applic. Date: 1996-08-13; WO1994GB02006 Applic. Date: 1994-09-14

Inventor: WILLIAMS TIMOTHY J [GB]; JOSE PETER J [GB]; GRIFFITHS-JOHNSON DAVID A [GB]; HSUAN JOHN J [GB]


Application No.: US20060179514A1  Published: 10/Aug/2006

Title: Methods for the production of multimeric protein complexes, and related compositions

Applicant/Assignee: SYNGENTA PARTICIPATIONS AG

Application No.: 10/952500   Filing Date: 29/Sep/2004

Abstract:Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobulins, in association with oil bodies are described. The redox protein is enzymatically active when prepared in association with the oil bodies. Also provided are related nucleic acids, proteins, cells, plants, and compositions.

Priority: US2001-032201 Applic. Date: 2001-12-19; US2001-006038 Applic. Date: 2001-12-04; US20010302885P Applic. Date: 2001-07-05

Inventor: ROOIJEN GIJS V [CA]; ZAPLACHINSKI STEVEN [CA]; HEIFETZ PETER B [US]; BRIGGS STEVEN [US]; DALMIA BIPIN K [US]; VAL GREG D [US]


Application No.: US20060179582A1  Published: 17/Aug/2006

Title: Natural aqueous composition and machine for dry-cleaning textiles and leathers

Applicant/Assignee: TEINTURERIE LESCHAEVE

Application No.: 10/551762   Filing Date: 03/Oct/2005

Abstract:The present invention relates to an aqueous composition for dry cleaning and/or degreasing textiles and/or leathers, which composition is natural and biodegradable. The dry cleaning composition of the invention comprises in particular essential oils and surface active agents, it is etherizable and micronizable, and its ingredients are exclusively of vegetable origin. The invention also relates to a method of dry cleaning and/or degreasing textiles and/or leathers implementing the above-described aqueous composition, the method comprising a succession of stages of tumbling the textiles and/or leathers in a leaktight enclosure, wherein one of the stages consists in impregnating the textiles and/or leathers with a small quantity of an aqueous composition by means of pneumatic atomization at a size no more than 50 mum, for a limited duration, and at a temperature of about 35 DEG to 45 DEG C., until the total weight gain is about 5% to 70%. The invention also relates to a machine for dry cleaning and/or degreasing textiles and/or leathers by implementing said method.

Priority: FR20030004249 Applic. Date: 2003-04-04; WO2004FR00826 Applic. Date: 2004-04-01

Inventor: LESCHAEVE PATRICK [FR]; ELOY CHRISTIAN [FR]


Application No.: US20060182652A1  Published: 17/Aug/2006

Title: Methods for sterilizing biological materials using dipeptide stabilizers

Applicant/Assignee: CLEARANT INC

Application No.: 11/399385   Filing Date: 07/Apr/2006

Abstract:Methods are disclosed for sterilizing biological materials to reduce the level of active biological contaminants or pathogens such as viruses, bacteria, nanobacteria, yeasts, molds, mycoplasmas, ureaplasmas, prions and parasites. These methods involve the use of dipeptide stabilizers in methods of sterilizing biological materials with irradiation.

Priority: US2001-925619 Applic. Date: 2001-08-10

Inventor: BURGESS WILSON [US]; DROHAN WILLIAM N [US]; MACPHEE MARTIN J [US]; MANN DAVID M [US]; MADDOX EWA [US]


Application No.: US20060182690A1  Published: 17/Aug/2006

Title: Alcoholic pump foam

Applicant/Assignee: STOCKHAUSEN GMBH

Application No.: 11/312559   Filing Date: 21/Dec/2005

Abstract:An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to <=99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of +-15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.

Priority: DE200410062775 Applic. Date: 2004-12-21

Inventor: VEEGER MARCEL [DE]; HIMMING MARKUS [DE]


Application No.: US20060182696A1  Published: 17/Aug/2006

Title: Water-soluble anti-dandruff compounds and compositions thereof

Applicant/Assignee: GALAXY SURFACTANTS LIMITED

Application No.: 11/226791   Filing Date: 14/Sep/2005

Abstract:Water-soluble and water dispersible undecylenic amido propyl dimethyl hydroxyl ethoxy ethyl ammonium undecylenate compounds of formula I having anti-dandruff, preservative and sunscreen activity wherein R1, R2 are from C1-C6 carbon atoms, R3 is undecylenic acid, amino group is selected from dimethyl amino propyl amine. Personal care compositions comprising compounds of formula I

Priority: IN2005MU00156 Applic. Date: 2005-02-14

Inventor: PATIL SUDHIR [IN]; MHATRE DILIP [IN]; D SOUZA AVILA [IN]


Application No.: US20060182708A1  Published: 17/Aug/2006

Title: Prebiotically active plant extracts

Applicant/Assignee:

Application No.: 11/336164   Filing Date: 20/Jan/2006

Abstract:The invention relates to plant extracts that have a prebiotic effect on skin, topical cosmetic and pharmaceutical compositions containing said plant extracts, and the use of said plant extracts and compositions, especially for treating the skin.

Priority: DE20031033245 Applic. Date: 2003-07-21; DE200410011968 Applic. Date: 2004-03-10; WO2004EP07708 Applic. Date: 2004-07-13

Inventor: BOCKMUHL DIRK [DE]; HOHNE HEIDE-MARIE [DE]; JASSOY CLAUDIA [DE]; SCHOLLYSSEK REGINE [DE]; WALDMANN-LAUE MARIANNE [DE]; SCHOLZ WOLFHARD [DE]; SATTLER ANDREA [DE]


Application No.: US20060182720A1  Published: 17/Aug/2006

Title: Cell preparation and use of the preparation for treating joints and cartilage defects, and methods for the production thereof

Applicant/Assignee:

Application No.: 10/549684   Filing Date: 19/Sep/2005

Abstract:The invention relates to a cell preparation for therapeutic and/or cosmetic use in humans and/or animals, containing: a) human or animal cells, which

b) had been cultured while using a substance or substance mixtures that activates) CD44 expression of these cells, and which present an increased CD44 expression of these cells.

Priority: DE20031011889 Applic. Date: 2003-03-18; WO2004EP02820 Applic. Date: 2004-03-18

Inventor: WOHLRAB DAVID [DE]


Application No.: US20060182766A1  Published: 17/Aug/2006

Title: Stabilized protein compositions for topical administration and methods of making same

Applicant/Assignee:

Application No.: 11/057481   Filing Date: 14/Feb/2005

Abstract:A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition comprises collagen, elastin, sphingoside and cerebroside. Also provided are pharmaceutical or cosmetic formulations comprising an effective amount of an active agent and the stabilizing composition as well as methods of administering active agents topically or transdermally.

Priority:

Inventor: MODI PANKAJ [CA]


Application No.: US20060182772A1  Published: 17/Aug/2006

Title: Method for the extemporaneous preparation of cosmetic compositions having the texture of a cream and compositions for carrying out said method

Applicant/Assignee:

Application No.: 10/527948   Filing Date: 14/Nov/2005

Abstract:The invention relates to a method for the preparation of cosmetic compositions having the texture of a cream. Said preparation is made at the time when the composition is used and includes bringing the following elements into contact with each other: (A) a liquid phase

(B) a powder containing a gelling agent for the liquid phase (A)

and (C) an active cosmetic ingredient, whereby the elements are brought into contact by adding phase (A) to phase (B), subjecting a solid powder containing phase (B) and phase (A) in an immobilized form to mechanical stress, said mechanical stress releasing phase (A). The invention also relates to compositions which can be used in the above context, especially (1) compositions containing phase (B) (to which phase (A) is added prior to use)

and (2) solid compositions comprising phase (B) and phase (A) in an immobilized form (and which are transformed into a cream when they are applied to the skin).

Priority: FR20020011515 Applic. Date: 2002-09-17; WO2003FR02732 Applic. Date: 2003-09-16

Inventor: SEU-SALERNO MARTINE [FR]; FILLARDET LAURENCE [FR]; BOULIER VIRGINIE [FR]


Application No.: US20060182788A1  Published: 17/Aug/2006

Title: Hydrophilic biocompatible adhesive formulations and uses

Applicant/Assignee:

Application No.: 11/341085   Filing Date: 27/Jan/2006

Abstract:This invention relates to the use of hydrophilic, biocompatible adhesives in drug delivery systems, wound dressings, bioelectrodes, and other systems in which hydrophilic, biocompatible adhesives are desirable. In particular, the invention relates to water-swellable, water-insoluble polymers that in combination render a composition adhesive upon contact with moisture, wherein a first water-swellable, water-insoluble polymer is cationic, a second water-swellable, water-insoluble polymer is anionic, and the polymers are ionically associated with each other to form a polymer matrix.

Priority: US20050648093P Applic. Date: 2005-01-27

Inventor: SINGH PARMINDER [US]; LEE EUN S [US]; SAGI APPALA [US]; FELDSTEIN MIKHAIL M [RU]; BAIRAMOV DANIR F [US]


Application No.: US20060182790A1  Published: 17/Aug/2006

Title: Dermal medicaments application enhancer

Applicant/Assignee:

Application No.: 11/356015   Filing Date: 17/Feb/2006

Abstract:A topical medicament for use in treating tissues comprising: an enhancer for facilitating non-invasive, transdermal delivery and/or enhancing metabolic effect of a therapeutic dosage of LEVULAN(R) KERASTICK(TM) (aminolevulinic acid HCl) into a tissue. The present invention provides a topical, transdermal medicament for use in treating tissues comprising an enhancer for facilitating non-invasive, transdermal delivery of a therapeutic dosage of comprising LEVULAN(R) KERASTICK(TM) (aminolevulinic acid HCl) into a tissue for example wherein the enhancing agent is comprising L.M.X.4(R)The enhancer may be selected from the group consisting of lidocaine, benzyl alcohol, carbomer 940, cholesterol, hydrogenated lecithin, polysorbate 80, propylene glycol, trolamine, vitamin E acetate and water or combinations thereof. The present invention, also, provides a pharmaceutical composition useful for treating tissues in humans and animals which comprises a therapeutically effective amount of LEVULAN(R) KERASTICK(TM) (aminolevulinic acid HCl) or pharmaceutically acceptable salt thereof in combination with a synergistically effective amount of at least one enhancer or pharmaceutically acceptable carrier wherein said enhancer is selected from the group consisting of lidocaine, benzyl alcohol, carbomer 940, cholesterol, hydrogenated lecithin, polysorbate 80, propylene glycol, trolamine, vitamin E acetate and water. The invention, also, provides a method of treating or preventing a human or animal afflicted by a diseases comprising topically administering a pharmaceutical composition which comprises of a therapeutically effective amount of aminolevulinic acid HCl in combination with an enhancer and/or a pharmaceutically acceptable carrier. The invention, also, provides a method wherein the composition further comprises a synergistically effective amount of an enhancer and/or pharmaceutically acceptable salt thereof wherein said enhancer is selected from the group consisting of lidocaine, benzyl, carbomer 940, cholesterol, hydrogenated lecithin, polysorbate 80, propylene glycol, trolamine, vitamin E acetate, water and combinations thereof.

Priority: US20050653487P Applic. Date: 2005-02-17

Inventor: MAYORAL FLOR [US]


Application No.: US20060182794A1  Published: 17/Aug/2006

Title: Stabilized compositions for topical administration and methods of making same

Applicant/Assignee: DPM THERAPEUTICS CORP

Application No.: 11/259778   Filing Date: 27/Oct/2005

Abstract:A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition preferably comprises collagen, elastin, sphingoside and cerebroside. Also provided are pharmaceutical or cosmetic formulations comprising an effective amount of an active agent and the stabilizing composition as well as methods of administering active agents topically or transdermally.

Priority: US2005-057481 Applic. Date: 2005-02-14

Inventor: MODI PANKAJ [CA]


Application No.: US20060182824A1  Published: 17/Aug/2006

Title: Use of galactomannans as an active cosmetic agent

Applicant/Assignee:

Application No.: 11/341106   Filing Date: 27/Jan/2006

Abstract:This invention relates to a method for increasing the adhesion of basal keratinocytes to the Dermoepidermal Junction (DEJ) in a subject, comprising administrating an effective amount of a cosmetic or dermatological composition comprising galactomannans on the skin of the subject, in particular for preventing and/or treating skin aging.

Priority: FR20050000889 Applic. Date: 2005-01-28

Inventor: LUCAS CAROLINE [FR]; POIRIER FREDERIQUE [FR]; LAPERDRIX CELINE [FR]


Application No.: US20060183664A1  Published: 17/Aug/2006

Title: Pharmaceutical composition for delayed hypersensitivity

Applicant/Assignee:

Application No.: 10/496851   Filing Date: 27/May/2004

Abstract:The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

Priority: GB20010029848 Applic. Date: 2001-12-13; GB20010031103 Applic. Date: 2001-12-31; WO2002GB05658 Applic. Date: 2002-12-13

Inventor: TAKIZAWA TOSHIAKI [JP]; TAMIYA MASAKI [JP]; SAITO NAOHIRO [JP]; KANKE TORU [JP]; MATSUMOTO JIRO [JP]; WADA YASUSHI [JP]; KAWAGOE JUNICHI [JP]; FERRELL WILLIAM R [GB]; LOCKHART JOHN C [GB]


Application No.: US20060183679A1  Published: 17/Aug/2006

Title: Peptides having a high cysteine content

Applicant/Assignee:

Application No.: 10/540305   Filing Date: 19/Dec/2005

Abstract:The invention relates to cysteine containing peptides of the structure XXCCXXXXXXXCXXXCXXXXXXQXXCXXXCXCXXXXXXXCXXXXXX, of the structure XXCCXXXXXXXCXXXCXXXXXXXXXCXXXCXCXXXXTXXCXXXXXX and of the structure XXCCXXXXXXXCXXXCXXXXXXXXXXCXXXCXCXXXXXXXXCXXXXXX, wherein X, independently of one another, represents any naturally occurring amino acid, as well as to nucleic acid sequences encoding said peptides, to vectors comprising said sequences, as well as to pharmaceutical compositions containing said peptides and their use as pharmaceutics, particularly for the treatment of cancers.

Priority: DE20021060537 Applic. Date: 2002-12-21; WO2003DE04228 Applic. Date: 2003-12-20

Inventor: KEREK FRANZ [DE]


Application No.: US20060183799A1  Published: 17/Aug/2006

Title: Biologically active oils

Applicant/Assignee:

Application No.: 10/559599   Filing Date: 02/Dec/2005

Abstract:A process for the production of fats or oils and their extracts containing biologically-active chemical compounds from a lipid substrate, the process comprising: a) inoculation of a lipid substrate with fungally derived lipolytic enzymes b) incubating the inoculated substrate for a period of between about 7-120 days at a temperature of between about 4-35 DEG C., at a humidity of between about 75-100%, and C) processing said substrate mixture to obtain a biologically active fat or oil.

Priority: AU20030902823 Applic. Date: 2003-06-04; WO2004AU00745 Applic. Date: 2004-06-04

Inventor: TURNER ATHOL GILLIES [AU]


Application No.: US20060183822A1  Published: 17/Aug/2006

Title: Ampholytic copolymer and use thereof

Applicant/Assignee:

Application No.: 10/541157   Filing Date: 30/Jun/2005

Abstract:The present invention relates to an ampholytic copolymer, to polyelectrolyte complexes which comprise such an ampholytic copolymer, and to cosmetic or pharmaceutical compositions which comprise at least one ampholytic copolymer or one polyelectrolyte complex.

Priority: DE20021061750 Applic. Date: 2002-12-30; WO2003EP14944 Applic. Date: 2003-12-29

Inventor: NGUYEN-KIM SON [DE]; SCHUCH HORST [DE]; KAISER THOMAS [DE]; WOOD CLAUDIA [DE]


Application No.: US20060188457A1  Published: 24/Aug/2006

Title: Bodywashes containing additives

Applicant/Assignee: AQUEA SCIENTIFIC CORPORATION

Application No.: 11/350397   Filing Date: 07/Feb/2006

Abstract:The invention encompasses bodywashes containing an additive. The additive may contain a sunscreen. The additive may contain 2, 3, or more than three sunscreens. Optionally, one or more of the sunscreens may be encapsulated. The invention further encompasses methods of making and using bodywashes containing an additive, e.g., an additive containing a sunscreen.

Priority: US2005-076517 Applic. Date: 2005-03-08; US2005-076565 Applic. Date: 2005-03-08; US2005-076089 Applic. Date: 2005-03-08; US2005-076088 Applic. Date: 2005-03-08; US2005-076507 Applic. Date: 2005-03-08; US20050648961P Applic. Date: 2005-01-31

Inventor: TRAYNOR DANIEL H [US]; MARKOWITZ STEVEN M [US]; COMPTON DAVID L [US]; TRAYNOR HENRY G [US]; DULAK MICHAEL [US]


Application No.: US20060188458A1  Published: 24/Aug/2006

Title: Sunscreen compositions and methods of use

Applicant/Assignee: AQUEA SCIENTIFIC CORPORATION

Application No.: 11/350409   Filing Date: 07/Feb/2006

Abstract:The invention encompasses additives for addition to a bodywash, where the additives contain one or more sunscreens, and where a bodywash which contains the additive imparts to the skin an SPF of at least about 2, in some cases at least about 5, or 10, or 15. Also described are methods of making and using the additives.

Priority: US2005-076565 Applic. Date: 2005-03-08; US2005-076088 Applic. Date: 2005-03-08; US2005-076089 Applic. Date: 2005-03-08; US2005-076517 Applic. Date: 2005-03-08; US2005-076507 Applic. Date: 2005-03-08; US20050648961P Applic. Date: 2005-01-31

Inventor: TRAYNOR DANIEL H [US]; MARKOWITZ STEVEN M [US]; COMPTON DAVID L [US]; TRAYNOR HENRY G [US]; DULAK MICHAEL [US]


Application No.: US20060188462A1  Published: 24/Aug/2006

Title: Skin care compositions containing a sugar amine

Applicant/Assignee:

Application No.: 11/412355   Filing Date: 27/Apr/2006

Abstract:Topical skin care compositions containing sugar amines in combination with selected skin care actives and methods of using such compositions to regulate the condition of skin are disclosed. The compositions contain a safe and effective amount of a sugar amine in combination with either a safe and effective amount of a terpene alcohol and a safe and effective amount of a retinoid

a safe and effective amount of a terpene alcohol and a safe and effective amount of a peptide

a safe and effective amount of a retinoid and a safe and effective amount of a peptide

a safe and effective amount of tocopherol sorbate

or a safe and effective amount of a vitamin B3 compound.

Priority: US2002-097716 Applic. Date: 2002-03-13; US20010277805P Applic. Date: 2001-03-22

Inventor: BISSETT DONALD L [US]; GOODMAN LAURA J [US]; JEWELL-MOTZ ELIZABETH A [US]


Application No.: US20060188467A1  Published: 24/Aug/2006

Title: Skin care composition containing a sugar amine

Applicant/Assignee:

Application No.: 11/412259   Filing Date: 27/Apr/2006

Abstract:Topical skin care compositions containing sugar amines in combination with selected skin care actives and methods of using such compositions to regulate the condition of skin are disclosed. The compositions contain a safe and effective amount of a sugar amine in combination with either a safe and effective amount of a terpene alcohol and a safe and effective amount of a retinoid

a safe and effective amount of a terpene alcohol and a safe and effective amount of a peptide

a safe and effective amount of a retinoid and a safe and effective amount of a peptide

a safe and effective amount of tocopherol sorbate

or a safe and effective amount of a vitamin B3 compound.

Priority: US2002-097716 Applic. Date: 2002-03-13; US20010277805P Applic. Date: 2001-03-22

Inventor: BISSETT DONALD L [US]; GOODMAN LAURA J [US]; JEWELL-MOTZ ELIZABETH A [US]


Application No.: US20060188468A1  Published: 24/Aug/2006

Title: Cosmetic and pharmaceutical substances based on polyelectrolyte complexes

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 10/564627   Filing Date: 13/Jul/2004

Abstract:The present invention relates to cosmetic and pharmaceutical compositions which comprise at least one polyelectrolyte complex which comprises a copolymer with cationogenic groups based on vinylimidazole and an acid-group-containing polymer. The invention further relates to the use of these polyelectrolyte complexes.

Priority: DE20031031870 Applic. Date: 2003-07-14; WO2004EP07742 Applic. Date: 2004-07-13

Inventor: NGUYEN-KIM SON [DE]; MULLER GABI [DE]; WOOD CLAUDIA [DE]; HOSSEL PETER [DE]


Application No.: US20060188533A1  Published: 24/Aug/2006

Title: Delivery of bio-available compounds with anhydrous topical preparations

Applicant/Assignee:

Application No.: 11/340043   Filing Date: 26/Jan/2006

Abstract:The disclosed systems and methods for delivery of bio-available compounds in topical preparations generally include anhydrous carrier particles adapted to carry bio-available compounds. The carrier particles may be admixed with anhydrous formulation material that is suitably adapted to suspend and/or separate the carrier particles. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to realize improved production and/or use of carrier particles that may be employed to deliver bio-available compounds in order to achieve a desired purpose. Exemplary embodiments of the present invention generally provide anhydrous carrier particles that may be mixed with substantially anhydrous topical preparations.

Priority: US20050647677P Applic. Date: 2005-01-26; US20050670570P Applic. Date: 2005-04-11

Inventor: BROWN J S [US]; HILL JOHN [US]; TRYON J R [US]; WARD MICHELE [US]


Application No.: US20060188546A1  Published: 24/Aug/2006

Title: Medical devices employing novel polymers

Applicant/Assignee: POLYMERIX CORPORATION

Application No.: 10/716577   Filing Date: 18/Nov/2003

Abstract:Medical devices with at least one surface comprising a polymer or polymers on the surface are provided. The polymer or polymers are capable of breaking down (e.g., including, but not limited to, hydrolyzing) in the physiologic milieu to form an active agent or agents under physiologic conditions, and can contain other active agents dispersed within or appended to the polymer matrix. Methods of delivering an active agent to an interior surface of a vein or artery are also provided.

Priority: US2002-273244 Applic. Date: 2002-10-17; US2000-627215 Applic. Date: 2000-07-27; US1999-422294 Applic. Date: 1999-10-21; WO1998US18816 Applic. Date: 1998-09-10; US2001-917194 Applic. Date: 2001-07-27; US20020427476P Applic. Date: 2002-11-18; US19970058328P Applic. Date: 1997-09-10; US20010261337P Applic. Date: 2001-01-12; US20000220707P Applic. Date: 2000-07-27

Inventor: GIROUX KAREN [US]


Application No.: US20060188558A1  Published: 24/Aug/2006

Title: Transdermal systems having control delivery system

Applicant/Assignee: MYLAN TECHNOLOGIES, INC

Application No.: 11/062084   Filing Date: 18/Feb/2005

Abstract:Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.

Priority:

Inventor: JACKSON KRISTIN [US]; MILLER KENNETH J II [US]; BHAT PAVAN [US]


Application No.: US20060188573A1  Published: 24/Aug/2006

Title: Composite materials and particles

Applicant/Assignee:

Application No.: 11/336819   Filing Date: 23/Jan/2006

Abstract:A method or concept for producing a composite material having at least an amphifilic (i.e., surface-active) and polymer component, and the composite material formed thereby, includes providing a mixture of at least one each of polymer and amphifilic compound in a volatile solvent or solvent mixture and providing a phase diagram of the chemical system describing how the components of the chemical system interact in thermodynamic stable phases as a function of temperature, concentration and pressure. The polymer should be a homopolymer, a random block copolymer or a mixture thereof, preferably biodegradable. The amphifilic compound can form a bilayer-containing phase. The solvent is removed from the mixture by a process selected from the phase diagram considering the desired final composite material, whereby a material is formed. The composite material is useful for applications such as encapsulation of therapeutically active components or for applications such as surface coating.

Priority: SE20030001722 Applic. Date: 2003-06-10; WO2004SE00917 Applic. Date: 2004-06-10

Inventor: IMBERG ANNA [SE]


Application No.: US20060189552A1  Published: 24/Aug/2006

Title: Dispenser for dispensing three or more actives

Applicant/Assignee:

Application No.: 11/339650   Filing Date: 25/Jan/2006

Abstract:Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first active ingredient are packaged within and dispensed from a common dispenser. By packaging these two active ingredients in this manner, long shelflife and convenient dispensing and application are provided.

Priority: US2002-121839 Applic. Date: 2002-04-12; US2000-734748 Applic. Date: 2000-12-12

Inventor: VISHNUPAD MOHAN [US]; VISHNUPAD NAOMI [US]


Application No.: US20060189631A1  Published: 24/Aug/2006

Title: Substituted imidazopyrimidines for the prevention and treatment of cancer

Applicant/Assignee: LABORATORIOS S.A.L.V.A.T., S.A

Application No.: 11/340856   Filing Date: 27/Jan/2006

Abstract:Compounds of general formula (I), wherein from A1 to A5, and from B1 to B5 are H, alkyl, alkoxyl, halogen, carboxylic derivatives or sulfur derivatives, among others

and from P1 to P3 are H, halogen, alkyl or alkoxyl, among others. Said compounds may be used for the chemoprevention and treatment of both precancerous lesions and cancer.

Priority: ES20030001906 Applic. Date: 2003-07-30; WO2004EP08476 Applic. Date: 2004-07-29

Inventor: CATENA RUIZ JUAN L [ES]; GALLEMI CARLES F [ES]; SERRAT ANNA F [FR]; COMAS CARMEN S [ES]; BALSA LOPEZ DOLORS [ES]; LAGUNAS ARNAL CARMEN [ES]; SALCEDO ROCA CAROLINA [ES]; FERNANDEZ GARCIA ANDRES [ES]


Application No.: US20060189691A1  Published: 24/Aug/2006

Title: Use of urocanic acid being able to acidify the cell cytoplasm and for preventing or halting cellular proliferation in a person

Applicant/Assignee:

Application No.: 10/565202   Filing Date: 26/Nov/2004

Abstract:The use of urocanic acid or another pharmaceutically acceptable agent being able to acidify the cell cytoplasm, for the manufacture of a pharmaceutical composition useful for causing inhibition or halting of transformed or non-transformed cell proliferation in a person or an animal, where an effective amount of the agent is administered in an essentially non-dissociated form to the person or animal. The use of the agent as an enhancer for other therapeutically active agents, and a pharmaceutical composition, are also disclosed.

Priority: FI20030001793 Applic. Date: 2003-12-09; WO2004FI00717 Applic. Date: 2004-11-26

Inventor: LEINO LASSE [FI]; LAIHIA JARMO [FI]


Application No.: US20060189692A1  Published: 24/Aug/2006

Title: Novel anti-proliferative pharmaceutical composition

Applicant/Assignee: BIOCIS PHARMA OY

Application No.: 11/408056   Filing Date: 21/Apr/2006

Abstract:The use of urocanic acid or another pharmaceutically acceptable agent being able to acidify the cell cytoplasm for the manufacture of a pharmaceutical composition useful for causing inhibition or halting of transformed or non-transformed cell proliferation in a person or an animal, where an effective amount of the agent is administered in an essentially non-dissociated form to the person or animal. The use of the agent as an enhancer for other therapeutically active agents, and a pharmaceutical composition, are also disclosed.

Priority: FI20030001793 Applic. Date: 2003-12-09; US2004-565202 Applic. Date: 2004-11-26; WO2004FI00717 Applic. Date: 2004-11-26

Inventor: LEINO LASSE [FI]; LAIHIA JARMO [FI]


Application No.: US20060190299A1  Published: 24/Aug/2006

Title: Active agent delivery method

Applicant/Assignee:

Application No.: 11/399815   Filing Date: 07/Apr/2006

Abstract:A method for active agent delivery is provided which includes orchestrating focus groups and clinical studies and the distribution of educational materials and guidelines for counseling patients with regard to what the patients need to know and what the patients must do in order to both avoid adverse side effects while taking doses of active agent and to receive prescriptions for the doses.

Priority: US2004-016188 Applic. Date: 2004-12-17; US2002-308332 Applic. Date: 2002-12-02

Inventor: JOSHI TERESA G [US]; WALKER PATRICIA S [US]


Application No.: US20060191995A1  Published: 31/Aug/2006

Title: Secure transaction system

Applicant/Assignee: SOURCE, INC

Application No.: 11/343734   Filing Date: 31/Jan/2006

Abstract:The system of the present invention comprises a personal Virtual Safety Deposit Box where users are able to enroll their identification methods, financial accounts and personal information. Once authenticated, this information is transferred to a master file within a central databank. Enrollment enables the user to link each item (collectively referred to as the "stored data") to any one of the plurality of identification methods they enter. Thereafter, the user may employ their enrolled identification methods to select a desired one of the stored data fields. A secure intermediary uses the identification method and a selection method to determine which of the stored data fields the user desires to employ by accessing a database containing each of the stored data fields and the corresponding selection method. The selected field is activated and any relevant outside agencies are notified of the transaction and the transaction is concluded.

Priority: US20050649372P Applic. Date: 2005-02-01; US20050677075P Applic. Date: 2005-05-03

Inventor: STEWART RICHARD G [US]; STEWART RICHARD J [US]


Application No.: US20060193789A1  Published: 31/Aug/2006

Title: Film forming foamable composition

Applicant/Assignee: FOAMIX LTD

Application No.: 11/337747   Filing Date: 23/Jan/2006

Abstract:A foamable composition, includes (1) about 6% to about 70% by weight of at least one organic carrier

(2) about 0.1% to about 5% by weight of at least one surface-active agent

(3) about 0.01% to about 5% by weight of at least one film forming agent

(4) water

and (5) about 3% to about 25% by weight of the total composition of at least one liquefied or compressed gas propellant. The composition is substantially alcohol free and is used in treating, alleviating or preventing a disorder.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; WO2003IB05527 Applic. Date: 2003-10-24; US2004-922358 Applic. Date: 2004-08-20; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20030497648P Applic. Date: 2003-08-25

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20060193797A1  Published: 31/Aug/2006

Title: Chroman derivatives as lipoxygenase inhibitors

Applicant/Assignee: GALILEO PHARMACEUTICALS, INC

Application No.: 11/349813   Filing Date: 07/Feb/2006

Abstract:The present invention is concerned with certain novel derivatives of Formula I: wherein X and R<1 >to R<10 >are as described in the specification, and where either R<5 >is OH, -NRORor -NR-NRR, or R<7 >is -NRORor -NR-NRR, or C-R<7>R<8 >is C-NORor C-N-NRR, which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of skin care and/or pharmaceutical compositions for the treatment of lipoxygenase mediated disorders.

Priority: US20050656644P Applic. Date: 2005-02-25

Inventor: ZHANG WEI [US]; CHEN JIAN [US]; BODDUPALLI SEKHAR [US]


Application No.: US20060193798A1  Published: 31/Aug/2006

Title: Aqueous Polymer Dispersion

Applicant/Assignee:

Application No.: 11/381252   Filing Date: 02/May/2006

Abstract:An aqueous polymer dispersion prepared by free-radical polymerization of vinyl acetate in the presence of at least one ionic emulsifier, at least one free-radical initiator and at least one protective colloid, wherein the polymerization is carried out in the presence of a polymerization regulator and wherein the ratio by weight of protective colloid to ionic emulsifier is at least 4:1 and wherein the ratio by weight of vinyl acetate monomer to protective colloid is between 19:1 and 4:1.

Priority: DE20001048888 Applic. Date: 2000-09-29; DE20011022786 Applic. Date: 2001-05-10; US2003-381372 Applic. Date: 2003-03-25; WO2001EP11053 Applic. Date: 2001-09-25

Inventor: KOLTER KARL [DE]; ANGEL MAXIMILIAN [DE]; ZEITZ KATRIN [DE]


Application No.: US20060193804A1  Published: 31/Aug/2006

Title: Haircare use of cyclic amine derivatives

Applicant/Assignee: L'OREAL

Application No.: 11/360518   Filing Date: 24/Feb/2006

Abstract:The present invention relates to a process for treating human keratin fibers and/or the skin from which the said fibers emerge, in order to induce and/or stimulate the growth of the human keratin fibers and/or to stop their loss and/or to increase their density, comprising at least the application, to the human keratin fibers and/or the skin, of a cosmetic composition comprising an effective amount of at least one piperidine derivative of general formula (I), in which: R1 denotes a halogen or a radical chosen from a linear or branched C1-C6 alkyl radical, a group OR, a group NRR', a CF3 group, a group NHCOR or a group CONRR'

R2 denotes a linear or branched C1-C20 alkyl or alkenyl radical, the hydrocarbon-based chain of which may be optionally interrupted with a -CO- function optionally substituted with at least one group OR, COOR, NRR', NHCOR or CONRR' and/or with a phenyl group optionally substituted with one or more radicals R1

with R and R' denoting, independently of each other, a hydrogen atom or a linear or branched C1-C6 alkyl radical, m represents an integer ranging from 0 to 5

and n represents an integer ranging from 0 to 5. or a salt or isomer thereof, leaving the said composition in contact with the keratin fibers and/or the skin from which the fibers emerge, and optionally rinsing the keratin fibers and/or the skin.

Priority: FR20050050512 Applic. Date: 2005-02-24; US20050685878P Applic. Date: 2005-06-01

Inventor: CAVEZZA ALEXANDRE [FR]


Application No.: US20060193809A1  Published: 31/Aug/2006

Title: Skin care compositions containing a sugar amine cross reference to related application

Applicant/Assignee:

Application No.: 11/412264   Filing Date: 27/Apr/2006

Abstract:Topical skin care compositions containing sugar amines in combination with selected skin care actives and methods of using such compositions to regulate the condition of skin are disclosed. The compositions contain a safe and effective amount of a sugar amine in combination with either a safe and effective amount of a terpene alcohol and a safe and effective amount of a retinoid

a safe and effective amount of a terpene alcohol and a safe and effective amount of a peptide

a safe and effective amount of a retinoid and a safe and effective amount of a peptide

a safe and effective amount of tocopherol sorbate

or a safe and effective amount of a vitamin B3 compound.

Priority: US2002-097716 Applic. Date: 2002-03-13; US20010277805P Applic. Date: 2001-03-22

Inventor: BISSETT DONALD L [US]; GOODMAN LAURA J [US]; JEWELL-MOTZ ELIZABETH A [US]


Application No.: US20060193811A1  Published: 31/Aug/2006

Title: Composition serving as a carrier for delivery of active ingredients in cosmetic and dermatological applications

Applicant/Assignee: ION LABS, INC

Application No.: 11/356550   Filing Date: 17/Feb/2006

Abstract:The present invention is for a carrier comprising an oil/water emulsion for delivery of active ingredient in a medium of cream or lotion for skin cosmetic and/or dermatological care.

Priority: US20050656591P Applic. Date: 2005-02-25

Inventor: OLIVER WILLIAM A III [US]; RIVERA ADALBERTO [US]


Application No.: US20060193812A1  Published: 31/Aug/2006

Title: Controlled delivery system for fragrance comprising a (METH)acrylate/hydroxy (METH) acrylate copolymer

Applicant/Assignee:

Application No.: 11/386966   Filing Date: 21/Mar/2006

Abstract:A perfuming composition for application to the skin by means of a roll-on, pump-spray, squeeze bottle or aerosol spray type device. The composition includes a perfuming base and, optionally, a deodorant or antiperspirant base, with at least one of the bases being combined with a film-forming substrate and an emulsifier so as to form an emulsion. The emulsion, once dried on the skin, provides for in-situ encapsulation of the perfuming base so as to prevent release of the latter until a surge of skin perspiration or contact with a moisture source takes place, and for in-situ re-encapsulation of the perfuming base upon the subsequent drying of the skin. The film-forming substrate is preferably an acrylates/hydroxyacrylates copolymer that is used with other components or that is used alone.

Priority: WO2003IB04378 Applic. Date: 2003-10-02; WO2004IB03160 Applic. Date: 2004-09-27

Inventor: HOLZNER GUNTER [CH]; PINEL NATHALIE [FR]


Application No.: US20060193921A1  Published: 31/Aug/2006

Title: Hydrophilic beads for use in topical formulations

Applicant/Assignee:

Application No.: 11/340310   Filing Date: 26/Jan/2006

Abstract:A composition and method for producing hydrophilic beads for use in topical formulations is described as generally including gellan gum, salts of divalent cations and water. Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to realize improved production and/or use of hydrophilic beads to achieve a particular desired purpose. Exemplary embodiments of the present invention generally provide hydrophilic beads that may be comixed with cosmetic, cosmeceutical and/or topical preparations for surface abrasion or as carriers for the delivery of other compounds

such as, aloe vera, ascorbic acid, active agents, and/or the like.

Priority: US20050647530P Applic. Date: 2005-01-26

Inventor: BROWN J S [US]; HILL JOHN [US]; TRYON J R [US]; WARD MICHELE [US]


Application No.: US20060194767A1  Published: 31/Aug/2006

Title: Novel agents for preventing and treating disorders involving modulation of the RyR receptors

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 11/212309   Filing Date: 25/Aug/2005

Abstract:The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases

exercise-induced irregular heartbeat disorders and diseases

sudden cardiac death

exercise-induced sudden cardiac death

congestive heart failure

chronic obstructive pulmonary disease

and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia

atrial and ventricular fibrillation

atrial and ventricular tachyarrhythmia

atrial and ventricular tachycardia

catecholaminergic polymorphic ventricular tachycardia (CPVT)

and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

Priority: US2004-809089 Applic. Date: 2004-03-25; US2004-763498 Applic. Date: 2004-01-22; US2003-680988 Applic. Date: 2003-10-07; US2003-608723 Applic. Date: 2003-06-26; US2002-288606 Applic. Date: 2002-11-05; US2000-568474 Applic. Date: 2000-05-10; US2004-794218 Applic. Date: 2004-03-05; US20030452664P Applic. Date: 2003-03-07

Inventor: MARKS ANDREW R [US]; LANDRY DONALD W [US]; DENG SHIXIAN [US]; CHENG ZHEN Z [US]; LEHNART STEPHAN E [US]


Application No.: US20060194846A1  Published: 31/Aug/2006

Title: [1,2,4]-Dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Applicant/Assignee: SOLVAY PHARMACEUTICALS B.V

Application No.: 11/349910   Filing Date: 09/Feb/2006

Abstract:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein wherein the symbols have the meanings given in the specification.

Priority: US20050651661P Applic. Date: 2005-02-11

Inventor: FEENSTRA ROELOF W [NL]; KEIZER HISKIAS G [NL]; PRAS-RAVES MARIA L [NL]; VAN VLIET BERNARD J [NL]; VAN SCHARRENBURG GUSTAAF J [NL]


Application No.: US20060198797A1  Published: 07/Sep/2006

Title: Stand-alone or enhancer composition for oral care

Applicant/Assignee:

Application No.: 11/356316   Filing Date: 15/Feb/2006

Abstract:A biological tissue care composition, such as an oral care composition, for enhancing the effects of whitening compositions. A solvent and surfactant is used with an alkaline builder and an optional saponifier. A method of use of such a composition includes use as a tooth cleaning composition. Alternatively the composition may be used as a stand-alone cleaning composition.

Priority: US20050734549P Applic. Date: 2005-11-07; US20050734477P Applic. Date: 2005-11-07

Inventor: GINIGER MARTIN S [US]


Application No.: US20060198800A1  Published: 07/Sep/2006

Title: Skin care compositions including hexapeptide complexes and methods of their manufacture

Applicant/Assignee:

Application No.: 11/347587   Filing Date: 04/Feb/2006

Abstract:Skin care compositions disclosed herein include, at a minimum, safe and effective amounts of at least one wrinkle reduction agent, which is a hexapeptide, and a natural exfoliating complex. The skin care compositions provide natural skin exfoliation, reduce fine lines and wrinkles, and improve skin elasticity and firmness.

Priority: US2004-918135 Applic. Date: 2004-08-13; US20030495574P Applic. Date: 2003-08-14

Inventor: DILALLO NATALIE [US]; GALDERISI ALYSON [US]


Application No.: US20060198806A1  Published: 07/Sep/2006

Title: Capsaicinoid decontamination compositions and methods of use

Applicant/Assignee:

Application No.: 11/366327   Filing Date: 02/Mar/2006

Abstract:A therapeutic composition for inhibiting physiological responses elicited by exposure of skin to an irritant can be used to treat exposure to capsaicinoids or other chemical irritants. The therapeutic composition can include a carrier being present in an effective amount and form sufficient to be applied to skin and deliver active agents to the skin which has been previously exposed to a capsaicinoid. Also, the therapeutic composition can include a cooling agent in an effective amount within the carrier to provide a cooling sensation to the skin. Further, the therapeutic composition can include a capsaicin receptor antagonist in an effective amount within the carrier to inhibit calcium flux associated with activation of the capsaicin receptor by a capsaicinoid. The therapeutic composition can be part of a kit that also includes a cleansing composition, which is capable of cleaning and/or absorbing capsaicinoids from the skin.

Priority: US20050658822P Applic. Date: 2005-03-04

Inventor: REILLY CHRISTOPHER A [US]


Application No.: US20060199859A1  Published: 07/Sep/2006

Title: Topical medicaments and methods for photodynamic treatment of disease

Applicant/Assignee: XANTECH PHARMACEUTICALS, INC

Application No.: 11/429742   Filing Date: 08/May/2006

Abstract:New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs

the mouth and digestive tract and related organs

the urinary and reproductive tracts and related organs

the respiratory tract and related organs

various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery

and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

Priority: US2000-635276 Applic. Date: 2000-08-09; US1997-989231 Applic. Date: 1997-12-11; US1998-130041 Applic. Date: 1998-08-06; US1998-184388 Applic. Date: 1998-11-02; US1998-216787 Applic. Date: 1998-12-21; US19990149015P Applic. Date: 1999-08-13

Inventor: DEES H C [US]; SCOTT TIMOTHY C [US]; SMOLIK JOHN [US]; WACHTER ERIC A [US]; FISHER WALTER G [US]


Application No.: US20060200213A1  Published: 07/Sep/2006

Title: Method and apparatus for skin treatment

Applicant/Assignee:

Application No.: 11/332517   Filing Date: 17/Jan/2006

Abstract:Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.

Priority: US2005-119378 Applic. Date: 2005-05-02; US2001-933870 Applic. Date: 2001-08-22; US2001-819082 Applic. Date: 2001-02-15; US1998-203178 Applic. Date: 1998-11-30

Inventor: MCDANIEL DAVID H [US]


Application No.: US20060204459A1  Published: 14/Sep/2006

Title: Use of tyrosine inhibitors for whitening human skin and treating melanocyted dysfunction associated diseases

Applicant/Assignee:

Application No.: 10/490286   Filing Date: 23/Sep/2004

Abstract:The present invention relates to a method for whitening human skin and treating melanocyte dysfunction associated diseases comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

Priority: US20010323312P Applic. Date: 2001-09-20; WO2002IB04330 Applic. Date: 2002-09-20

Inventor: MOUSSY ALAIN [FR]; KINET JEAN P [US]


Application No.: US20060204469A1  Published: 14/Sep/2006

Title: Stable mixed emulsions

Applicant/Assignee:

Application No.: 11/369831   Filing Date: 08/Mar/2006

Abstract:Stable mixed emulsion systems containing at least two discrete and distinctly different dispersed particle size ranges, i.e., both nanoemulsion and macroemulsion semisolid dispersions, as well as a method of making the same, are disclosed. The stable mixed emulsions may be used for cosmetic and dermatological applications and provide unique benefits.

Priority: US20050659410P Applic. Date: 2005-03-09

Inventor: SPENGLER ERIC [US]; PETRAIA TERESA [US]


Application No.: US20060204470A1  Published: 14/Sep/2006

Title: Care and /or Make-Up Cosmetic Composition Structured with Silicone Polymers

Applicant/Assignee:

Application No.: 10/538924   Filing Date: 13/Jun/2005

Abstract:Care and/or make-up cosmetic composition comprising: a liquid continuous fatty Phase structured with at least one structuring polymer (homopolymer or copolymer) having a weight-average molecular mass ranging from 500 to 500 000, containing at least one moiety comprising: at least one polyorganosiloxane group consisting of I to 1 000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions, Chosen from ester, amide, sulphonamide, carbamate, thiocarbamate, urea, urethane, thiourea, oxamido, guanidino and biguanidino groups, and combinations thereof, the polymer being solid at room temperature and soluble in the liquid fatty Phase at a temperature of 25 to 250 DEG C., the Said liquid fatty Phase comprising at least one compound capable of reducing the enthalpy of fusion of the structuring polymer, and then the liquid fatty Phase, the structuring polymer and the compound capable of reducing the enthalpy of fusion of the structuring polymer forming a physiologically acceptable medium.

Priority: FR20020016040 Applic. Date: 2002-12-17; US20030438782P Applic. Date: 2003-01-09; WO2003EP15006 Applic. Date: 2003-12-08

Inventor: TOURNILHAC FLORENCE [FR]


Application No.: US20060204530A1  Published: 14/Sep/2006

Title: Benzoyl peroxide compositions and methods of use

Applicant/Assignee: JR CHEM, LLC

Application No.: 11/373538   Filing Date: 10/Mar/2006

Abstract:Solutions of benzoyl peroxide, in one or more solvents are provided that are suitable for direct topical application to the skin of a user or can be formulated into a product that is suitable for topical application to the skin of a user. In embodiments, the solutions include benzoyl peroxide and optionally additional active or inactive ingredients, and a solvent or mixture of solvents in which the benzoyl peroxide is prepared as a clear solution at 25 DEG C. Methods of using the solutions are also described. Product formulations such as emulsion are also described. The solutions and product formulations can increase the efficacy and percutaneous absorption of benzoyl peroxide.

Priority: US20050660386P Applic. Date: 2005-03-10; US20050695223P Applic. Date: 2005-06-29

Inventor: RAMIREZ JOSE E [US]; FARYNIARZ JOSEPH R [US]


Application No.: US20060204561A1  Published: 14/Sep/2006

Title: Device for delivery of TRPV1 agonists

Applicant/Assignee:

Application No.: 11/354349   Filing Date: 14/Feb/2006

Abstract:Described here are drug delivery devices including an occlusive backing layer and a drug depot containing a TRPV1 agonist and a non-hydrophilic solvent. The drug depot may take various forms, such as an adhesive polymeric matrix, liquid reservoir, or microreservoir droplets. Methods of making and using the drug delivery devices are also described.

Priority: US20050652923P Applic. Date: 2005-02-14

Inventor: MUHAMMAD NAWEED [US]; JAMIESON GENE C [US]; BLEY KEITH R [US]


Application No.: US20060204562A1  Published: 14/Sep/2006

Title: Microprojection arrays with improved biocompatibility

Applicant/Assignee:

Application No.: 11/355729   Filing Date: 15/Feb/2006

Abstract:A transdermal delivery member having a plurality of microprojections adapted to pierce the stratum corneum of a subject, each of the microprojection having a length less than 145 microns. In a preferred embodiment, each microprojection has a length in the range of approximately 50-145 microns.

Priority: US20050653675P Applic. Date: 2005-02-16

Inventor: CORMIER MICHEL J [US]; LIN WEIQI [US]; ZHANG CYNTHIA [US]; SAMIEE AHMAD P [US]; ANDERSON ROLFE [US]


Application No.: US20060204992A1  Published: 14/Sep/2006

Title: Method for determining hair cycle markers

Applicant/Assignee:

Application No.: 11/364118   Filing Date: 28/Feb/2006

Abstract:The invention relates to a method for determining hair cycle markers in vitro, test kits and biochips which are used to determine hair cycle markers and to the use of proteins, mRNA molecules, proteins or fragments thereof as hair cycle markers. The invention also relates to a test method which is used to detect the effectiveness of cosmetic and pharmaceutical active ingredients which influence the hair cycle, in addition to a screening method which is used to identify cosmetic or pharmaceutical active ingredients which influence the hair cycle and to a method for the production of a cosmetic and pharmaceutical preparation which influences the hair cycle.

Priority: DE20031040373 Applic. Date: 2003-08-30; WO2004EP09435 Applic. Date: 2004-08-24

Inventor: HOLTKOTTER OLAF [DE]; PETERSOHN DIRK [DE]; SCHLOTMANN KORDULA [DE]; GIESEN MELANIE [DE]; KESSLER-BECKER DANLALA [DE]


Application No.: US20060205708A1  Published: 14/Sep/2006

Title: Aryl oximes

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 11/429181   Filing Date: 08/May/2006

Abstract:Aryl oxime derivatives of the formula (I), in which R<1>, R<2>, R<3>, X and B are as defined in Claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

Priority: DE20021025574 Applic. Date: 2002-06-10; US2004-517438 Applic. Date: 2004-12-10

Inventor: EGGENWEILER HANS-MICHAEL [DE]; BEIER NORBERT [DE]; SCHELLING PIERRE [DE]; WOLF MICHAEL [DE]


Application No.: US20060210500A1  Published: 21/Sep/2006

Title: Formulations

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 10/553671   Filing Date: 17/Oct/2005

Abstract:The present invention relates to formulations for topical applications comprising pigments obtainable by agitating a suspension comprising one or more inorganic pigments and silver oxide, in order to reduce undesirable side effects caused by microorganisms.

Priority: US20030463726P Applic. Date: 2003-04-18; WO2004EP03090 Applic. Date: 2004-03-24

Inventor: BICARD-BENHAMOU VALERIE [DE]; BUCHHOLZ HERWIG [DE]; BRUNNER MARKUS [DE]


Application No.: US20060210508A1  Published: 21/Sep/2006

Title: Fragrance delivery system for surface cleaners and conditioners

Applicant/Assignee: FIRMENICH SA

Application No.: 11/408179   Filing Date: 21/Apr/2006

Abstract:We claim a fragrance delivery system consisting of a mixture of various polymers oligomers and stabilizers capable of forming a surfactant complex gel dispersion when combined with a cleansing surfactant base and yielding high levels of fragrance deposition onto the skin, hair or other surface such as a textile, from a cleansing or softening consumer product comprising a micelle forming surfactant. The internal phase or dispersible phase of this surfactant complex gel dispersion (GLPPD) is made of a mixture of various immiscible polymers, oligomers and stabilizers forming a complex gel with the surfactant platform and whose ratio and composition are selected to dissolve preferentially a wide range of fragrance raw materials.

The selection criteria are, first, that the fragrance should present a higher fragrance partitioning ratio into the surfactant complex gel phase than into the free micelles of the surfactant, second, that the surfactant complex gel should not be further solubilized by the free micelles, and third, that the polymer mixture selected should complex with the surfactant system. The external or dispersing phase of the GLPPD is made of a single cationic polymer or a mixture of cationic polymers that have been hydrated and associated with the surfactant to form a complex gel structure that cannot be further solubilized by the free micelles.

Priority: WO2003IB04867 Applic. Date: 2003-10-31; WO2004IB03544 Applic. Date: 2004-10-28; US20030516548P Applic. Date: 2003-10-31

Inventor: GAMEZ-GARCIA MANUEL [US]


Application No.: US20060210553A1  Published: 21/Sep/2006

Title: Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation

Applicant/Assignee: CREABILIS THERAPEUTICS S.R.L

Application No.: 10/565170   Filing Date: 23/Jul/2003

Abstract:The present invention relates to the use of the alkaloid K252 and its analogues or derivatives to prepare topical drugs for the treatment of disorders characterised by hyperproliferation of keratinocytes.

Priority: WO2003EP08077 Applic. Date: 2003-07-23

Inventor: PINCELLI CARLO [IT]


Application No.: US20060210619A1  Published: 21/Sep/2006

Title: Limposomes containing asiaticoside and the uses thereof

Applicant/Assignee:

Application No.: 10/544088   Filing Date: 30/Jan/2004

Abstract:This invention belongs to the chemical field, which is related to the fields of pharmaceutical preparations and cosmetic, especially to asiaticoside-liposome and its use for preparing pharmaceutical preparations and cosmetic. In this invention, asiaticoside and lipid components are fused by heating or dissolved in organic solvents, then treated with the rotary thin layer evaporation technique, hydrated by adding aqueous solution under shaking to afford lipid dispersing aqueous solution, and then treated by using the technics of sonication, homogeneous emulsification, microjet and extruding filtration to enwrap asiaticoside in the middle of liposomal bilayer membranes to form the hydrophilic asiaticoside-liposome. Asiaticoside-liposome of this invention can enhance the stability, skin penetrability and hydrophilicity of asiaticoside, it can be used for the preparation of cosmetic and pharmaceutical preparations especially skin-penetrated pharmaceutical preparations, and it is more convenient and easy to prepare skin-penetrated pharmaceutical preparations and cosmetic containing asiaticoside.

Priority: CN20031015296 Applic. Date: 2003-01-30; WO2004CN00086 Applic. Date: 2004-01-30

Inventor: CHEN JIANMING [CN]; LU LUO [CN]; GAO SHEN [CN]; LIN HUIFEN [CN]; WEI SHAOMIN [CN]; ZHANG YANGMEI [CN]; LI HUILIANG [CN]; ZHONG YANQIANG [CN]; SHI QING [CN]; GUO YIQUANG [CN]; GUAN FEI [CN]; WANG WEI [CN]; MA LAIJI [CN]; GU JUAN [CN]


Application No.: US20060210991A1  Published: 21/Sep/2006

Title: Interleukin-8 homologous polypeptides and therapeutic uses thereof

Applicant/Assignee:

Application No.: 10/795503   Filing Date: 09/Mar/2004

Abstract:The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

Priority: US2001-015967 Applic. Date: 2001-12-07; US2001-941992 Applic. Date: 2001-08-28; WO2000US08439 Applic. Date: 2000-03-30; WO2001US06520 Applic. Date: 2001-02-28; US2000-709238 Applic. Date: 2000-11-08; WO2000US23328 Applic. Date: 2000-08-24; WO1999US12252 Applic. Date: 1999-06-02; US19980090696P Applic. Date: 1998-06-25

Inventor: EATON DAN L [US]; FRENCH DOROTHY [US]; GRIMALDI J C [US]; HILLAN KENNETH J [US]; PISABARRO MARIA T [DE]; SCHMIDT KERSTIN N [US]; SMITH VICTORIA [US]; TUMAS DANIEL [US]; VANDLEN RICHARD [US]; WATANABE COLIN K [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]


Application No.: US20060211752A1  Published: 21/Sep/2006

Title: Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression

Applicant/Assignee:

Application No.: 11/130922   Filing Date: 17/May/2005

Abstract:The present invention relates to the treatment of autoimmune and/or inflammatory diseases associated with overexpression of Toll-like receptor 3 (TLR3) as well as Toll-like receptor 4 (TLR4) and/or TLR3/TLR4 signaling in nonimmune cells, monocytes, macrophages, and/or dendritic cells in association with related pathologies. This invention also relates to the use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune and inflammatory diseases associated with Toll-like receptor 3 (TLR3) as well as Toll-like receptor 4 (TLR4) and/or TLR3/TLR4 signaling in nonimmune cells, monocytes, macrophages, and/or dendritic cells in association with related pathologies. This invention also relates to treating a subject having a disease or condition associated with abnormal Toll-like receptor 3 as well as Toll-like receptor 4 and/or TLR3/TLR4 signaling in nonimmune cells, monocytes, macrophages, and/or dendritic cells in association with related pathologies. The present invention also relates to the treatment of autoimmune-inflammatory pathologies and chemokine and cytokine-mediated diseases associated with TLR overexpression and signaling. This invention also relates to pharmaceutical formulations capable of inhibiting the IRF-3/Type 1 IFN/STAT/ISRE/IRF-1 pathway associated with Toll-like receptor overexpression or signaling.

Priority: US2004-912948 Applic. Date: 2004-08-06; US2004-801986 Applic. Date: 2004-03-16

Inventor: KOHN LEONARD D [US]; HARII NORIKAZU [JP]; BENAVIDES-PERALTA URUGUAYSITO [UY]; GONZALEZ-MURGUIONDO MARIANA [UY]; LEWIS CHRISTOPHER J [US]; NAPOLITANO GIORGIO [IT]; GIULIANI CESIDIO [IT]; MALGOR RAMIRO [US]; GOETZ DOUGLAS J [US]


Application No.: US20060211978A1  Published: 21/Sep/2006

Title: Method for treatment of skin diseases and the like

Applicant/Assignee:

Application No.: 11/080707   Filing Date: 15/Mar/2005

Abstract:A disposable swab tipped medication applicator containing one or more pharmacologically active agents in an anhydrous crystalline or powdered form at the swab. A method for use of the swab tipped applicator provides for delivery the pharmacological agent(s) to an area of the skin, such as the external auditory canal, preferably after showering or bathing, so that the dry agent is dampened so as to treat conditions of the skin. A package of the prepared applicators is provided in one embodiment, while in another embodiment applicators having two different medicaments are provided in a single package for treatment of a condition.

Priority:

Inventor: DO TED GERARD VAN ACKER [US]


Application No.: US20060212029A1  Published: 21/Sep/2006

Title: Equipment and method for reducing and eliminating wrinkles in the skin

Applicant/Assignee:

Application No.: 10/544723   Filing Date: 05/Aug/2005

Abstract:A mechanism for preparing the area of the skin to be treated and a mechanism for applying energy thereto both being integrated in the same equipment. The mechanism for preparing the are to be treated comprises an ultrasonic emitting device (preferably low frequency ultrasound) and/or dermabrasion device for breaking the lipid lamellar organization and reducing the dispersion of the irradiated energy altering the ultra-structure of the lipid corneal layer. The mechanism for applying energy comprises an emitting device capable to emit several combined forms of energy to the area to be treated. There is provided an atomizing device for applying topical agents and/or drugs to the area to be treated which cooperates with the mechanism for preparing the area to be treated. The method provides emitting laser light and polarized light, intense pulsed light without polarization and polarized light, or intense pulsed light with polarization and polarized light.

Priority: WO2004ES00046 Applic. Date: 2004-02-20

Inventor: ARCUSA VILLACAMPA FRANCISCO J [ES]; FRANCO LISSOTT MAILIN A [ES]; CAMBIER BERNARD [ES]; SOPHIE DU WOLF ANNE [ES]


Application No.: US20060216252A1  Published: 28/Sep/2006

Title: Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin

Applicant/Assignee: CIBA SPECIALTY CHEMICALS HOLDING INC

Application No.: 10/564712   Filing Date: 07/Jul/2004

Abstract:The use of hydroxydiphenyl ether compounds of formula (I), wherein R1, R2 and R3 are each independently of the others hydrogen

hydroxy

C1-C20alkyl

hydroxy-substituted C1-C20alkyl

C5-C7cycloalkyl

C1-C20alkoxy

C1-C6alkylcarbonyl

phenyl

or phenyl-C1-C3alkyl

R4 is hydrogen, C1-C20alkyl

hydroxy-substituted C1-C20alkyl

C5-C7cycloalkyl

hydroxy

formyl

acetonyl

allyl

carboxy

carboxy-C1-C3alkyl

carboxyallyl

C2-C20alkenyl

C1-C6alkylcarbonyl

C1-C3alkylcarbonyl-C1-C3alkyl

phenyl

or phenyl-C1-C3alkyl

and R5 is hydrogen

C1-C20alkoxy

or C1-C6alkylcarbonyl

as melanogenesis inhibitors and for lightening the skin.

Priority: EP20030405542 Applic. Date: 2003-07-16; WO2004EP51379 Applic. Date: 2004-07-07

Inventor: BASCHONG WERNER [CH]; SCHNYDER MARCEL [CH]


Application No.: US20060216255A1  Published: 28/Sep/2006

Title: Medicinal cosmetical composition with areca catechu seed extract

Applicant/Assignee:

Application No.: 10/553261   Filing Date: 02/Dec/2005

Abstract:The present invention relates to a composition for promoting the proliferation of fibroblasts and kerathincytes comprising a mixed extract from Areca catechu seed and Glycyrrhiza glabra and a cosmetic composition for skin-whitening and a remedy of skin wrinkles comprising the same.

Priority: WO2003KR00733 Applic. Date: 2003-04-11

Inventor: LEE KUN-KOOK [KR]; LEE KWANG-SIK [KR]


Application No.: US20060216340A1  Published: 28/Sep/2006

Title: Method of providing sustained analgesia with buprenorphine

Applicant/Assignee: EURO-CELTIQUE, S.A

Application No.: 11/442512   Filing Date: 26/May/2006

Abstract:A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.

Priority: US2003-402288 Applic. Date: 2003-03-28; US2001-033056 Applic. Date: 2001-12-27; US2001-756419 Applic. Date: 2001-01-08; US1999-311997 Applic. Date: 1999-05-14; US1997-939068 Applic. Date: 1997-09-29; US19970038919P Applic. Date: 1997-02-24

Inventor: REDER ROBERT F [US]; GOLDENHEIM PAUL D [US]; KAIKO ROBERT F [US]


Application No.: US20060216350A1  Published: 28/Sep/2006

Title: Ganglionic blocking agents for the treatment of epithelial diseases

Applicant/Assignee:

Application No.: 11/089713   Filing Date: 24/Mar/2005

Abstract:Compositions, and methods of making and using a composition, containing a ganglionic blocking agent and water provide increased penetration of the ganglionic blocking agent into and through epithelial surfaces, such as skin and mucosal surfaces, provide increased release from formulations containing such ganglionic blocking agents, and provide increased antiviral effectiveness compared with compositions containing a ganglionic blocking agents and lacking water.

Priority:

Inventor: DOW GORDON J [US]; BUCKS DANIEL A [US]; DESAI NAYAN [US]


Application No.: US20060217286A1  Published: 28/Sep/2006

Title: Composition for cleaning or rinsing hard surfaces

Applicant/Assignee:

Application No.: 10/546768   Filing Date: 19/Dec/2003

Abstract:Composition for cleaning or rinsing hard surfaces in an aqueous or aqueous/alcoholic medium comprising at least one polybetaine for contributing to said surfaces antideposition and/or antiadhesion properties with regard to soiling substances capable of being deposited on said surface.

Priority: FR20030002079 Applic. Date: 2003-02-20; FR20030009527 Applic. Date: 2003-08-01; WO2003FR03841 Applic. Date: 2003-12-19

Inventor: GEOFFROY CEDRIC [FR]; HARRISON IAN [FR]; LABEAU MARIE-PIERRE [FR]


Application No.: US20060217307A1  Published: 28/Sep/2006

Title: Methods for regulating inflammatory mediators and peptides useful therein

Applicant/Assignee: NORTH CAROLINA STATE UNIVERSITY BIOMARCK PHARMACEUTICALS, LTD

Application No.: 11/367449   Filing Date: 06/Mar/2006

Abstract:The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from the vesicles or granules in the inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. MANS peptide and active fragments thereof are useful in such methods.

Priority: US2004-802644 Applic. Date: 2004-03-17; US2002-180753 Applic. Date: 2002-06-26; US20010300933P Applic. Date: 2001-06-26

Inventor: TAKASHI SHUJI [JP]; PARIKH INDU [US]; ADLER KENNETH B [US]; MARTIN LINDA D [US]; LI YUEHUA [US]


Application No.: US20060217426A1  Published: 28/Sep/2006

Title: Compound inhibiting in vivo phosphorous transport and medicine containing the same

Applicant/Assignee: KIRIN BEER KABUSHIKI KAISHA

Application No.: 10/550857   Filing Date: 29/Mar/2004

Abstract:An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and custom character represents a single bond or a double bond, R<5 >represents optionally substituted aryl or the like, Z represents -N-CHR<6>R<7 >or the like, R<6 >and R<7 >represent H, optionally substituted alkyl, optionally substituted aryl or the like, R<101 >and R<102 >together form -O, and R<103 >and R<104 >represent H, or R<101 >and R<104 >together from a bond, and R<102 >and R<103 >together form a bond.

Priority: JP20030089173 Applic. Date: 2003-03-27; WO2004JP04427 Applic. Date: 2004-03-29

Inventor: ETO NOBUAKI [JP]; NAGAO RIKA [JP]; KAZAMA TETSUKO [JP]


Application No.: US20060217788A1  Published: 28/Sep/2006

Title: Method of using laser induced injury to activate topical prodrugs

Applicant/Assignee:

Application No.: 11/318372   Filing Date: 22/Dec/2005

Abstract:Methods and compositions are disclosed for improving the wound healing process and increasing collagen synthesis following laser induced thermal injury. The method comprises delivering prodrugs to a target site before the target site is injured and taking advantage of those enzymes that are physiologically-expressed to promote wound healing to convert the prodrugs to active drugs. The claimed invention has the advantage of the prodrugs being readily available to immediately participate in the wound healing process, but not have any negative side-effects of the active drug being present before injury occurs.

Priority: US2004-888356 Applic. Date: 2004-07-09; US20040638933P Applic. Date: 2004-12-23

Inventor: HERRON G S [US]; BOMMANNAN D B [US]


Application No.: US20060222686A1  Published: 05/Oct/2006

Title: Dry products comprising an applicator and a wax phase

Applicant/Assignee:

Application No.: 10/520970   Filing Date: 08/Jul/2003

Abstract:This invention concerns products for cleansing and other applications, which products comprise an applicator such as a puff (pouf), pad, sponge, cotton ball, swab, brush, glove, mitt or bar, to which a wax phase has been applied. The invention further concerns the manufacture and use of such products.

Priority: WO2003EP07398 Applic. Date: 2003-07-08

Inventor: HAUSER MATTHIAS [DE]; ANSMANN ACHIM [DE]; ISSBERNER ULRICH [DE]; JACKWERTH BETTINA [DE]; LEONARD MARK [DE]


Application No.: US20060223804A1  Published: 05/Oct/2006

Title: NK1 antagonists

Applicant/Assignee: SCHERING CORPORATION OPKO HEALTH, INC

Application No.: 11/172289   Filing Date: 30/Jun/2005

Abstract:A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Priority: US20040584502P Applic. Date: 2004-07-01

Inventor: SHAH SAPNA S [US]; SHIH NENG-YANG [US]; PALANI ANANDAN [US]; HUANG XIANHAI [US]; XIAO DONG [US]; PALIWAL SUNIL [US]; TSUI HON-CHUNG [US]; WROBLESKI MICHELLE L [US]; RAO ASHWIN U [US]; WANG CHENG [US]


Application No.: US20060223814A1  Published: 05/Oct/2006

Title: Nk-2 antagonist basic linear compounds and formulations containing them

Applicant/Assignee:

Application No.: 10/554152   Filing Date: 22/Oct/2005

Abstract:The present invention describes compounds with formula (I) having linear structure basic properties useful as NK-2 antagonists

pharmaceutical compositions containing said compounds are also described and processes for their preparation.

Priority: IT2003FI00113 Applic. Date: 2003-04-24; WO2004EP50592 Applic. Date: 2004-04-23

Inventor: FATTORI DANIELA [IT]; PORCELLONI MARINA [IT]; D ANDREA PIERRO [IT]; ROSSI CRISTINA [IT]; ALTAMURA MARIA [IT]; MAGGI CARLO A [IT]


Application No.: US20060225285A1  Published: 12/Oct/2006

Title: Razor head with mild cleansing composition as a shaving aid

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/103769   Filing Date: 12/Apr/2005

Abstract:A razor head assembly is described that contains a mild cleansing composition including acyl isethionate surfactant(s) positioned adjacent to a blade for shaving and treating the skin. The isethionate surfactants provide the user with nearly simultaneous moisturization, cleansing and shaving. An after shave phase is provided in addition to the cleansing phase in a preferred embodiment.

Priority:

Inventor: SLAVTCHEFF CRAIG S [US]; MERAVIGLIA SANDRA D [US]; ABBAS SYED H [US]


Application No.: US20060226773A1  Published: 12/Oct/2006

Title: Light emitting display

Applicant/Assignee: LG ELECTRONICS INC LG DISPLAY CO., LTD

Application No.: 11/397671   Filing Date: 05/Apr/2006

Abstract:The present invention provides a light emitting display with excellent reliability by preventing degradation by heat such as color changes or luminance reduction, through uniform and quick discharge of heat generated internally.

Priority: KR20050028733 Applic. Date: 2005-04-06; KR20050038967 Applic. Date: 2005-05-10; KR20050038936 Applic. Date: 2005-05-10

Inventor: KIM WOOCHAN [KR]; YOON JONG G [KR]


Application No.: US20060229239A1  Published: 15/Jan/2004

Title: Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis

Applicant/Assignee:

Application No.: 10/383898   Filing Date: 07/Mar/2003

Abstract:The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. The present invention provides methods to deliver a cytotoxic compound, such as a curcuminoid, specifically to cancer cells and to the vascular endothelial cells that nourish solid tumors. The method involves tethering the drug to a protein such as in factor VIIa that retains high affinity for the surface protein tissue factor. Upon complexation, the resulting heterodimer is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The present invention further provides for the synthesis of novel curcuminoid-tether-linker-factor VIIa compositions and for methods of delivery of effective doses of the novel compositions to target tumor or endothelial cells in a patient

Priority: US20020362762P Applic. Date: 2002-03-08; US20020403794P Applic. Date: 2002-08-14

Inventor: SHOJI MAMORU [US]; SNYDER JAMES [US]; LIOTTA DENNIS [US]; SUN AIMING [US]


Application No.: US20060233714A1  Published: 19/Oct/2006

Title: Use of a volatile liquid at atmospheric pressure and ambient temperature for the production of pharmaceutical or biological compositions

Applicant/Assignee:

Application No.: 10/545553   Filing Date: 13/Feb/2004

Abstract:A liquid which is a perfluorinated compound whose vapor pressure at 25 DEG C. and atmospheric pressure is greater than or equal to 10,000 Pa (100 mbar) and whose boiling point is greater than or equal to 30 DEG C. is used in the manufacture of a pharmaceutical and/or biological composition. The pharmaceutical and/or biological composition essentially only includes this liquid and the pharmaceutical ingredient in powder form and/or the solid biological material. The pharmaceutical ingredient and/or the biological material are insoluble in the liquid. Optionally, a film-forming agent is also included.

Priority: FR20030001761 Applic. Date: 2003-02-13; WO2004FR50055 Applic. Date: 2004-02-13

Inventor: ASSIE JEAN-LOUIS [FR]; HUART JEAN-JACQUES [FR]


Application No.: US20060233721A1  Published: 19/Oct/2006

Title: Foam containing unique oil globules

Applicant/Assignee: FOAMIX LTD

Application No.: 11/389742   Filing Date: 27/Mar/2006

Abstract:The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water emulsion composition includes: an oil globule system, selected from the group consisting of oil bodies

and sub-micron oil globules, about 0.1% to about 5% by weight of an agent, selected from the group consisting of a surface-active agent, having an HLB value between 9 and 16

and a polymeric agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20050717058P Applic. Date: 2005-09-14

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]; EINI MEIR [IL]


Application No.: US20060233725A1  Published: 19/Oct/2006

Title: Non-Endocrine Disrupting Cytoprotective UV Radiation Resistant Substance

Applicant/Assignee:

Application No.: 10/485989   Filing Date: 05/Feb/2004

Abstract:Compositions for enhanced UV-protective agents that increase immuno-responsiveness by providing cytoprotective additives for mammalian skin by ensuring avoidance from endocrine disrupting agents are described. A composition comprising: (a) at least one inorganic non-endocrine disrupting sun-blocking agent or organic non-endocrine disrupting sunscreen agent, (b) at least one non-endocrine disrupting emollient or mixtures thereof and (c) an optional oil component comprising a carrier oil, preferably an essential oil of a naturally occuring substance and a method of making this and other embodiments of similar compositions of the same invention is detailed. Inorganic component (a) is titanium dioxide, zinc oxide, silica or silicon dioxide, fluoropolymers or mixtures thereof. Organic component (a) is butylmethoxy dibenzoylmethane. The non-endocrine disrupting component (b) is cold-processed Aloe barbadensis Miller, which contains a glucose-rich mannose-containing oligosaccharide or oligosaccharides, or a fatty acid salt such as sodium stearate. The compositions are shown to be capable of protecting skin and mammalian health from the harmful effects of radiation including ultraviolet light or sunlight by inhibiting the loss of skin immunocompetency and eliminating any known or suspected endocrine disrupting agents normally utilized as sun protective agents.

Priority: US2001-682249 Applic. Date: 2001-08-09; WO2002US24866 Applic. Date: 2002-08-08

Inventor: GRUNE GUERRY L [US]


Application No.: US20060233727A1  Published: 30/Mar/2006

Title: Film foaming hydroalcoholic foam

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/187217   Filing Date: 22/Jul/2005

Abstract:The present invention provides a foam composition comprising an active agent. In particular, the foam composition produces a water resistant, preferably very water resistant, film upon application.

Priority: WO2004AU00170 Applic. Date: 2004-02-12; US20030447445P Applic. Date: 2003-02-12

Inventor: HUGGINS JOAN K [AU]; HOULDEN ROBERT J [AU]


Application No.: US20060233736A1  Published: 19/Oct/2006

Title: Cosmetic compositions containing mono-hydroxyl substituted amines and acid derivatives

Applicant/Assignee: L'OREAL

Application No.: 11/108298   Filing Date: 18/Apr/2005

Abstract:Disclosed are cosmetic or dermatological compositions that include a mono-hydroxyl substituted amine such as dimethylaminoethanol (DMAE), a sulfonic, phosphoric, or phosphonic acid derivative, and a cosmetically acceptable carrier. Also disclosed are methods for making and using the compositions.

Priority:

Inventor: MEYERS ALAN [US]; HANSENNE ISABELLE [US]


Application No.: US20060233738A1  Published: 19/Oct/2006

Title: Composition for promoting production of type 1 collagen and/or elastin

Applicant/Assignee:

Application No.: 10/550224   Filing Date: 23/Mar/2004

Abstract:This invention aims to provide a composition that promotes the production of type I collagen and/or elastin in the human skin fibroblast cells, wherein the composition improves the suppleness and elasticity of the skin, is amply effective in preventing and improving wrinkles and sagging, and is also very safe to the skin. The present invention relates to a composition that contains silymarin, which is a general term for flavonolignans such as silybin, silydianin, silychristin and isosilybin, wherein the aforementioned composition has a property to promote the production of type I collagen and/or property to promote the production of elastin. It also relates to a composition containing silymarin derived from a silymarin-containing plant and/or extract of such plant, wherein the aforementioned composition also has a property to promote the production of type I collagen and/or property to promote the production of elastin.

Priority: JP20030083943 Applic. Date: 2003-03-25; WO2004JP03978 Applic. Date: 2004-03-23

Inventor: MIYATA SATOSHI [JP]; HANDA YOUKO [JP]; SAKURAI TETSUHITO [JP]


Application No.: US20060233764A1  Published: 19/Oct/2006

Title: Skin regeneration system

Applicant/Assignee:

Application No.: 10/565616   Filing Date: 28/Jul/2004

Abstract:A cell culture medium and system are provided which eliminate or at least reduce the requirement for exogenous components such as serum and feeder cells. The cell culture medium comprises an IGF and vitronectin or fibronectin and, optionally an IGFBP, and is particularly suitable for propagating keratinocytes for subsequent use in skin growth and regeneration. This invention also relates to compositions and methods for skin growth and regeneration in situ, which utilize aerosol delivery of cultured keratinocytes.

Priority: AU20030903896 Applic. Date: 2003-07-28; WO2004AU01006 Applic. Date: 2004-07-28

Inventor: UPTON ZEE [AU]; HARKIN DAMIEN [AU]; LEAVESLEY DAVID [AU]


Application No.: US20060233783A1  Published: 19/Oct/2006

Title: Topical composition in the form of a gel for treating skin burns

Applicant/Assignee:

Application No.: 10/552011   Filing Date: 07/Oct/2005

Abstract:The present invention relates to novel topical compositions for treating burns, grazes, erythema, eczema, herpes infection, evulsion, sores and any skin damage leading to sloughing, including at least three components, namely a first barrier gel, a second barrier gel and an active principle having proteolytic activity. The novel compositions have enhanced pain-killing, protective, débrding and anti-inflammatory effects relative to the conventional products used in the art.

Priority: WO2003IB01295 Applic. Date: 2003-04-09

Inventor: GOMEZ TORRES HAROLD A [CO]


Application No.: US20060235048A1  Published: 19/Oct/2006

Title: Treatment of connective tissue diseases of the skin

Applicant/Assignee: ASTION DEVELOPMENT A/S

Application No.: 11/402255   Filing Date: 12/Apr/2006

Abstract:The present invention provides effective and safe medicaments for the treatment of connective tissue diseases of the skin, particularly with respect to the treatment of cutaneous forms of Lupus Erythematous. The medicaments comprise as the therapeutically active ingredient a beta2 adrenoceptor agonist. The invention furthermore relates to dermatological compositions without skin sensitization properties and which contain enantiomerically pure or enriched R-enantiomers of a beta2 adrenoceptor agonist.

Priority: DK20050000529 Applic. Date: 2005-04-13

Inventor: WEIDNER MORTEN S [DK]


Application No.: US20060235071A1  Published: 19/Oct/2006

Title: Novel clerodanes and methods for repelling arthropods

Applicant/Assignee:

Application No.: 11/374866   Filing Date: 14/Mar/2006

Abstract:A method for repelling arthropods involving treating a subject or an object with an arthropod repelling composition containing an arthropod repelling effective amount of at least one clerodane of the formula in which R<1 >is H, halogen, formyl, a straight chain or branched C1-4 saturated alkyl, a straight chain or branched C2-4 unsaturated alkyl, or an aryl containing 6-10 carbon atoms in the ring skeleton thereof, wherein R<1 >is unsubstituted or substituted with one or more substituents, which are the same or different, selected from the group consisting of oxo (-O), OR<2>, CO2R<2>, and OC(O)R<2>, wherein R<2 >is H, a straight chain or branched C1-30 saturated alkyl, a straight chain or branched C2-30 unsaturated alkyl, or an aryl comprising 6-10 carbon atoms in the ring skeleton thereof

wherein R<2 >is unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, amino, hydroxyl, oxo (-O), thio, cyano and nitro

optionally a carrier, optionally an arthropod repellant, and optionally an insecticide. Preferably the compound is 13,14,15,16-tetranorclerod-3-en-12-al (callicarpenal), 13,14,15,16-tetranorclerod-3-en-12-ol, 13,14,15,16-tetranorclerod-3-en-12-oic acid, beta-epoxycallicarpenal, alpha-epoxycallicarpenal, or mixtures thereof. Also a compound of the above formula. Also an arthropod repellant composition containing an arthropod repelling effective amount of at least one of the compounds of the above formula and a carrier.

Priority: US20050672849P Applic. Date: 2005-04-19

Inventor: CANTRELL CHARLES L [US]; KLUN JEROME A [US]; DUKE STEPHEN O [US]


Application No.: US20060235222A1  Published: 19/Oct/2006

Title: Indole-derivative modulators of steroid hormone nuclear receptors

Applicant/Assignee: ELI LILLY AND COMPANY

Application No.: 10/542621   Filing Date: 15/Jul/2005

Abstract:The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.

Priority: US20030441947P Applic. Date: 2003-01-22; WO2004US00017 Applic. Date: 2004-01-20

Inventor: BELL MICHAEL G [US]; GAVARDINAS KONSTANTINOS [US]; GERNERT DOUGLAS L [US]; GRESE TIMOTHY A [US]; JADHAV PRABHAKAR K [US]; LANDER PETER A [US]; STEINBERG MITCHELL I [US]


Application No.: US20060235370A1  Published: 19/Oct/2006

Title: Method of regulating mammalian keratinous tissue

Applicant/Assignee:

Application No.: 11/363002   Filing Date: 27/Feb/2006

Abstract:Method for providing a benefit to mammalian keratinous tissue, comprising applying a composition comprising one or more hair growth regulating compounds to the keratinous tissue and delivering energy to the keratinous tissue by means of an energy delivery device.

Priority: US20050667930P Applic. Date: 2005-04-04; US20050692641P Applic. Date: 2005-06-21; US20050694758P Applic. Date: 2005-06-28

Inventor: OBLONG JOHN E [US]; MITRA SHEKHAR [US]; KEMP HELEN R [US]; EVANS MARK D [US]


Application No.: US20060239942A1  Published: 26/Oct/2006

Title: Stable transfer-resistant self-tanning gel containing a water-soluble or water-dispersible gelling agent

Applicant/Assignee: L'OREAL

Application No.: 11/110603   Filing Date: 20/Apr/2005

Abstract:A self-tanning aqueous gel composition containing: (a) a cosmetically acceptable support

(b) at least one monocarbonyl or polycarbonyl self-tanning agent

(c) at least one aqueous phase gelling agent comprising at least one water-soluble or water-dispersible, crosslinked or non-crosslinked polymer or copolymer

d) at least one tinting agent

and (e) optionally, at least one water-soluble or water-dispersible film-forming agent.

Priority:

Inventor: SHAH ANIL [US]; GALDI ANGELIKE [US]; HANSENNE ISABELLE [US]


Application No.: US20060239945A1  Published: 26/Oct/2006

Title: Cleansing composition

Applicant/Assignee: CONOPCO INC, D/B/A UNILEVER

Application No.: 11/315932   Filing Date: 21/Dec/2005

Abstract:A skin-lightening cleansing composition with a pH below 7.5 comprising 3% to 50% by weight of detergent active wherein nonionic detergent active when present, has a HLB in the range 5-18

and 0.01% to 20% by weight alkyl or cyclo alkyl resorcinol.

Priority: IN2004MU01403 Applic. Date: 2004-12-24

Inventor: BAPAT MOHINI A [IN]; CHANDAR PREM [US]; VERMA RITU [SG]; VETHAMUTHU MARTIN S [US]


Application No.: US20060239947A1  Published: 26/Oct/2006

Title: Biliquid foams stable dispersions thereof and a corresponding process of manufacturing

Applicant/Assignee:

Application No.: 10/566210   Filing Date: 30/Jul/2004

Abstract:A biliquid foam comprising from 10% to 98% by weight of a non-polar liquid other than a fuel and from 2 to 88% by weight of a continuous phase polar liquid comprising a C1-C4 alcohol, a liquid polyethylene glycol, ethylene glycol or propylene glycol, or mixtures thereof, in an amount of at least 65% by weight, relative to the weight of the continuous phase, wherein the biliquid foam is stabilized with an amount of from 0.05% to 2% by weight based on the total formulation of a surfactant which is selected from castor oil/poly(alkylene glycol) adducts containing from 20 to 50 alkoxy groups, a C8-C24 fatty acid or hydrogenated castor oil/poly(alkylene glycol) adducts containing from 20 to 60 alkoxy groups, or mixtures thereof. A stable dispersion having a content of at least 65% by weight with regard to C1-C4 alcohol, liquid polyethylene glycol, ethylene glycol or propylene glycol which dispersion comprises from 1-80% by weight of a biliquid foam and from 99-20% by weight of an aqueous gel.

Priority: GB20030017868 Applic. Date: 2003-07-30; WO2004GB03318 Applic. Date: 2004-07-30

Inventor: DIAS MONICA [GB]; GUFFOGG PHILIP [GB]; WHEELER DEREK [GB]; WHITEBREAD-JORDAN MARK [GB]


Application No.: US20060239949A1  Published: 26/Oct/2006

Title: Silicone elastomer exfoliating compositions

Applicant/Assignee: E-L MANAGEMENT CORP

Application No.: 11/112400   Filing Date: 23/Apr/2005

Abstract:Compositions of the present invention comprise from about 40-99% of an aqueous suspension of silicone elastomer powder in a cosmetically acceptable vehicle. The compositions are useful as skin exfoliants when mechanical agitation is supplied, for example by rubbing with a hand. After exfoliation, little or no film or residue remains on the skin and washing the treated area is optional. The cosmetically acceptable vehicle may comprise a wide range of beneficial ingredients, cosmetic or dermatological actives and additives. The present invention also encompasses a method of exfoliating skin in need of such treatment.

Priority:

Inventor: MOHAMMADI FATEMEH [US]; TALATI AKSHAY [US]; CZARNOTA ANNA [US]


Application No.: US20060239957A1  Published: 26/Oct/2006

Title: Cosmetic and dermopharmaceutical compositions for skin prone to acne

Applicant/Assignee: SEDERMA SAS

Application No.: 11/390710   Filing Date: 28/Mar/2006

Abstract:The invention relates to the use of an extract of olive leaves (Olea europaea) which is titrated in oleanolic acid and which may or may not be associated with a Larrea divaricata extract which is titrated in nordihydroguaiaretic acid (NDGA). Said products are intended for all types of cosmetic and dermopharmaceutical compositions for all forms of skin care, for moisturizing and anti-inflammatory purposes and, in particular, for the prevention and treatment of skin prone to acne.

Priority: FR20010012802 Applic. Date: 2001-10-03; US2004-817670 Applic. Date: 2004-04-02; WO2002FR03344 Applic. Date: 2002-10-01

Inventor: LINTNER KARL [FR]


Application No.: US20060240084A1  Published: 26/Oct/2006

Title: Microbial cellulose materials for use in transdermal drug delivery systems, method of manufacture and use

Applicant/Assignee: XYLOS CORPORATION

Application No.: 11/406528   Filing Date: 19/Apr/2006

Abstract:A method for transdermally delivering a biologically active agent to a subject in need thereof, comprising topically applying a composition comprising insoluble microbial cellulose, water, and a therapeutically effective amount of the biologically active agent, wherein the biologically active agent penetrates through the subject's stratum corneum at a substantially constant rate.

Priority: US20050672880P Applic. Date: 2005-04-20

Inventor: SERAFICA GONZALO [US]; MINK RICHARD [US]; HOON RUSSELL [US]; DAMIEN CHRISTOPHER [US]


Application No.: US20060240422A1  Published: 26/Oct/2006

Title: Caspase 10 as target for monitoring and treatment of diseases

Applicant/Assignee: DEUTSCHES KREBSDORSCHUNGSZENTRUM STIFUNG DES OFFENTLICHEN RECHTS

Application No.: 10/525681   Filing Date: 23/Feb/2005

Abstract:The present invention relates to a method of monitoring and/or modulating disease-associated activatory procceses which are mediated by caspase-10 or caspase-10 isoforms.

Priority: EP20020018908 Applic. Date: 2002-08-23; WO2003EP09350 Applic. Date: 2003-08-22

Inventor: WALCZAK HENNING [DE]; SPRICK MARTIN [DE]


Application No.: US20060241067A1  Published: 26/Oct/2006

Title: Methods For inhibiting angiogenesis, cell migration, cell adhesion, and cell survival

Applicant/Assignee:

Application No.: 10/518181   Filing Date: 09/Sep/2005

Abstract:The invention relates to methods for detecting and inhibiting angiogenesis, cell migration, cell adhesion, and/or cell survival in endothelial and non-endothelial cells as well as in normal and tumor cells. The invention further relates to methods for screening test compounds for their ability to inhibit angiogenesis, cell migration, cell adhesion, and/or cell survival.

Priority: US20020391484P Applic. Date: 2002-06-25; WO2003US20041 Applic. Date: 2003-06-25

Inventor: VARNER JUDITH A [US]; BAKRE MANJIRI [SG]; JIN HUI [US]


Application No.: US20060241190A1  Published: 26/Oct/2006

Title: Keratolytic composition with anti-allergic anti-inflammatory properties

Applicant/Assignee:

Application No.: 10/551001   Filing Date: 26/Sep/2005

Abstract:A product with an enhanced medicinal and cosmetic composition with a specific utility of "Psoriasis, Eczema and like skin disorders application" is characterized by the fact that it comprises active agents and ingredients as vanilla extract, ammonium chloride, potassium chloride and quaternary ammonium compound having formulated at a specific pH value with other specially selected adjuvants and fillers.

Priority: IN2003KO00185 Applic. Date: 2003-03-27; WO2004IN00069 Applic. Date: 2004-03-26

Inventor: MUNISEKHAR MEDASANI [IN]


Application No.: US20060243273A1  Published: 02/Nov/2006

Title: Dispensing device

Applicant/Assignee:

Application No.: 10/502231   Filing Date: 25/Mar/2005

Abstract:The present invention relates to a method of dispensing a liquid suspension from a reservoir of a liquid suspension held in a delivery system, wherein the reservoir of liquid suspension is of a type which is normally isolated from atmosphere, comprising the steps of: a) increasing the volume of the reservoir above an initial volume so as to reduce the pressure in the reservoir to below atmospheric

b) agitating the liquid suspension

c) reducing the volume of the reservoir to the initial volume

and d) subsequently dispensing at least a portion of the liquid suspension from the reservoir.

Priority: GB20020001507 Applic. Date: 2002-01-23; WO2003GB00287 Applic. Date: 2003-01-23

Inventor: WRIGHT ANDREW D [GB]


Application No.: US20060246021A1  Published: 02/Nov/2006

Title: Sunless tanning composition and methods for using

Applicant/Assignee:

Application No.: 11/120132   Filing Date: 02/May/2005

Abstract:A sunless tanning composition is provided according to the invention. The sunless tanning composition includes an effective amount of a tanning active component to provide a darkening effect of skin tissue after exposure to the skin tissue, a polymer component, water, an effective amount of an acidifying agent to provide the composition with a pH of less than about 5, and wherein the composition has the viscosity of at least about 3,000 cSt. The polymer component can be characterized as a skin bonding polymer component to hold the tanning active component in exposure to the skin tissue when applied to the skin tissue. The polymer component can be characterized as a polymer having an average molecular weight of about 2,000 to about 500,000. A method of applying a sunless tanning composition to skin tissue is provided.

Priority:

Inventor: ROSZELL JAMES A [US]


Application No.: US20060246027A1  Published: 02/Nov/2006

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/120027   Filing Date: 02/May/2005

Abstract:Stable personal care composition comprising hydrophobic modified silica, a particulate material and a dermatologically-acceptable carrier, said carrier comprising about 70% or greater, by weight of the carrier, of at least one water-soluble polyol, said water-soluble polyol having a solubility parameter of from about 11 to about 17.

Priority:

Inventor: TANNER PAUL R [US]


Application No.: US20060247162A1  Published: 02/Nov/2006

Title: Skin collagen production promoter

Applicant/Assignee:

Application No.: 10/553830   Filing Date: 07/May/2003

Abstract:It is intended to provide a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which are useful in preventing skin chapping, wrinkles, worsening in skin fitness, etc. Namely, a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which contain as the active ingredient(s) a milk-origin basic protein fraction and/or a basic peptide fraction obtained by digesting the above-described basic protein fraction with a protein digesting enzyme such as pepsin or pancreatin. The above basic protein fraction and basic peptide fraction have an effect of increasing skin collagen level.

Priority: WO2003JP05707 Applic. Date: 2003-05-07

Inventor: MORITA YOSHIKAZU [JP]; TAKADA YUKIHIRO [JP]; TOBA YASUHIRO [JP]; OOI WATARU [JP]; KAWAKAMI HIROSHI [JP]


Application No.: US20060247195A1  Published: 02/Nov/2006

Title: Method of altering cell properties by administering rna

Applicant/Assignee: RIBOSTEM LIMITED

Application No.: 10/563897   Filing Date: 09/Jul/2004

Abstract:The invention relates to the alteration of cell properties using RNA molecules. In particular, it relates to the alteration of the ability of cells to mobilise, migrate, integrate, proliferate and/or differentiate. For example, it relates to the induction of differentiation of stem cells, including the acquisition of the ability to migrate, integrate, and proliferate. It also relates to the induction of in vivo stem cell mobilisation, migration, integration, proliferation and/or differentiation. Accordingly, it relates to the promotion of stem cell-mediated functional repair. The invention also relates to the reversal of differentiation of differentiated cells. All these effects may be effected by providing isolated RNA comprising a RNA sequence extractable from cells comprising the desired cell type(s) to a population of cells under conditions whereby the alteration of the cell property is achieved.

Priority: GB20030016089 Applic. Date: 2003-07-09; WO2004GB02981 Applic. Date: 2004-07-09

Inventor: RAY STEPHEN [GB]


Application No.: US20060247214A1  Published: 02/Nov/2006

Title: Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 11/476246   Filing Date: 28/Jun/2006

Abstract:A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.

Priority: US2001-774558 Applic. Date: 2001-01-31; US20000193845P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL A [US]; MCIVER JOHN M [US]; YOUNGQUIST ROBERT S [US]


Application No.: US20060247403A1  Published: 02/Nov/2006

Title: Polyether urethane containing allyl groups

Applicant/Assignee: BASF AKTIENGESELLSCHAFT BASF SE

Application No.: 10/538760   Filing Date: 10/Jun/2005

Abstract:The present invention relates to a mono- and/or polyallyl-polyether-urethane, to water-soluble or water-dispersible polymers which comprise such a polyether-urethane in copolymerized form, and to cosmetic or pharmaceutical compositions which comprise a water-soluble or water-dispersible polymer based on a mono- and/or polyallyl-polyether-urethane.

Priority: DE20021059036 Applic. Date: 2002-12-17; WO2003EP14357 Applic. Date: 2003-12-16

Inventor: NGUYEN-KIM SON [DE]; MATHAUER KLEMENS [DE]; WOOD CLAUDIA [DE]


Application No.: US20060247585A1  Published: 02/Nov/2006

Title: Disposable pads for applying and distributing substances to target surfaces

Applicant/Assignee:

Application No.: 11/274526   Filing Date: 15/Nov/2005

Abstract:The applicators, and methods for making them, their use in manually applying controllable amounts of moist, viscous lotions, creams, gels or dry powders onto target skin and hard surfaces. The applicators comprise an impervious backing sheet, a three-dimensional core layer with reservoirs in the shapes of cones or honeycombs wherein active compositions in the form of viscous lotions, gels, creams or dry powders are located, a microporous flow-directing cover sheet and an optional impervious overwrap. The applicator is capable of releasing the active composition in a controlled manner and protecting the user's hands from contacting the viscous material, to prevent potential soiling, cross-contamination and/or skin irritation. The applicators can be made to form hand or finger mitts, gloves, flat or tubular pads, wraps, facemasks, booties, and more.

Priority: US20040628171P Applic. Date: 2004-11-17

Inventor: KELLY ALBERT R [US]


Application No.: US20060248665A1  Published: 09/Nov/2006

Title: Encapsulated fragrance materials and methods for making same

Applicant/Assignee:

Application No.: 11/123898   Filing Date: 06/May/2005

Abstract:The present invention is directed to novel capsules containing active materials and methods for making capsules with enhanced performance and stability. The capsules are well suited for use in personal care applications, laundry products and perfume and fragrance products.

Priority:

Inventor: PLUYTER JOHAN G L [US]; ANASTASIOU THEODORE J [US]


Application No.: US20060251596A1  Published: 09/Nov/2006

Title: Deodorant agent

Applicant/Assignee: KAO CORPORATION

Application No.: 10/550858   Filing Date: 26/Sep/2005

Abstract:This invention relates to deodorant agents, which contain ginkgo or Phellodendron Bark or its extract as an active ingredient. According to the present invention, deodorant agents which are high in safety and can radically inhibit the emission of human body malodors typified by sweat odor, especially, axillary odor.

Priority: JP20030103171 Applic. Date: 2003-04-07; WO2003JP11982 Applic. Date: 2003-09-19

Inventor: AKIBA SYUNICHI [JP]; ARA KATSUTOSHI [JP]; KUSUOKU HIROSHI [JP]; HAGURA TOYOKI [JP]


Application No.: US20060251597A1  Published: 09/Nov/2006

Title: ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE

Applicant/Assignee:

Application No.: 11/381374   Filing Date: 03/May/2006

Abstract:This application discloses a composition comprising a malodor compound and an anti-odor ingredient effective for reducing the presence or production of malodor. The composition may be topically applied to a subject and is useful for cosmetic conditions, pharmaceutical indications, or other objectives.

Priority: US20050677364P Applic. Date: 2005-05-04

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]


Application No.: US20060251598A1  Published: 09/Nov/2006

Title: System for improved percutaneous absorption of skin benefiting agents

Applicant/Assignee:

Application No.: 11/291223   Filing Date: 01/Dec/2005

Abstract:Stable topical compositions containing active ingredients that are prone to oxidation, and methods for improving the percutaneous absorption of an active ingredient are provided.

Priority: US20040632499P Applic. Date: 2004-12-02

Inventor: RAMIREZ JOSE E [US]; MCNAMARA AUSTIN [US]; HATTENDORF JUDY [US]; GOLDNER STEVE [US]


Application No.: US20060251663A1  Published: 09/Nov/2006

Title: Employment of rotavirus proteins, derived proteins and peptides for the modulation of tisssue permeability

Applicant/Assignee:

Application No.: 10/540843   Filing Date: 10/Jan/2003

Abstract:The present invetnion refers to the use of rotavirus proteins VP4, VP8 and their derived fusion proteins and peptides, for enhancing the delivery of pharmaceutical agents through the paracellular pathway. These rotavirus proteins and derived peptides may additionally be employed to reduce unwanted cellular adhesion that can occur between cancerous cells, or between normal cells as a result of surgery, injury, chemotherapy, disease, inflammation or other pathological conditions.

Priority: WO2003IB00280 Applic. Date: 2003-01-10

Inventor: MARISCAL-GONZALEZ LORENZA [MX]; NAVA-DOMINGUEZ PORFIRIO [MX]


Application No.: US20060251703A1  Published: 09/Nov/2006

Title: Composition comprising an edible acid or its acidic salt and the use thereof

Applicant/Assignee:

Application No.: 10/554315   Filing Date: 24/Oct/2005

Abstract:This invention relates to a drug containing edible acid and/or acidic salt as active agent to treat and alleviate hypersensitivity diseases by lowering the humor pH and method

to improve individual hypersensitivity diseases by uses of health care food, which are made from said edible acid and/or acidic salt, or the acidic fruits containing thereof, or their products

foods lowering the risk of hypersensitivity and their preparation methods

drug to lower the humor acidity and to treat or alleviate disease caused by insects bite toxin

that also to be drug for cold or virus infection

drug for inflammation

drug for analgesic

and drug for thrombus disease

method lowers the hypersensitivity risk of clothing or grove and their products.

Priority: WO2003CN00299 Applic. Date: 2003-04-24; WO2004CN00402 Applic. Date: 2004-04-26

Inventor: SHIAO SHIN-JEN [TW]


Application No.: US20060251707A1  Published: 09/Nov/2006

Title: Uv stable transdermal therapeutic plaster

Applicant/Assignee:

Application No.: 10/545826   Filing Date: 26/May/2006

Abstract:The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

Priority: EP20030003888 Applic. Date: 2003-02-21; EP20030004061 Applic. Date: 2003-02-25; WO2004EP01052 Applic. Date: 2004-02-04

Inventor: SCHUMACHER JOCHEN [DE]; SUESSE MANFRED [DE]; DITTGEN MICHAEL [DE]; MLETZKO STEPHAN [DE]; INGWERSEN JAN-PETER [DE]; LANGGUTH THOMAS [DE]; SCHENK DIRK [DE]; KAFFL HUBERT [DE]


Application No.: US20060252036A1  Published: 09/Nov/2006

Title: Alteration of rab38 function to modulate mammalian pigmentation

Applicant/Assignee: PAVAN AND LOFTUS

Application No.: 10/501611   Filing Date: 20/Oct/2005

Abstract:The present invention relates to compositions and methods involving melanocytes. In particular, the present invention provides compositions and methods involving RAB38 and mutant RAB38, suitable for use in modulation of pigmentation and for use in determining the means to diagnose and/or treat conditions associated with disorders in pigmentation.

Priority: US20020349929P Applic. Date: 2002-01-18; WO2003US01622 Applic. Date: 2003-01-17

Inventor: PAVAN WILLIAM J [US]; LOFTUS STACIE K [US]


Application No.: US20060252679A1  Published: 09/Nov/2006

Title: Preventive and/or trerapeutic drgs for itch

Applicant/Assignee:

Application No.: 10/525324   Filing Date: 22/Feb/2005

Abstract:The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof

[wherein R<1 >represents substituted or unsubstituted lower alkyl, etc.

R<2 >represents hydrogen, substituted or unsubstituted lower alkyl, etc.

R<3 >and R<4 >are the same or different and each represents hydrogen, lower alkyl, etc.

n represents 0 or 1

X represents -(CH2)2-, etc.

and Y represents the formula (II)

(wherein W represents CH or a nitrogen atom

Z<1 >and Z<2 >are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.

and Z<3 >represents hydrogen, substituted or unsubstituted lower alkyl, etc.)]

Priority: JP20020241522 Applic. Date: 2002-08-22; WO2003IB03475 Applic. Date: 2003-08-22

Inventor: SAKI MAYUMI [JP]; NONAKA HIROMI [JP]; MIYAJI HIROMASA [JP]; ICHIKAWA SHUNJI [JP]; TAKASHIMA CHIEMI [JP]; MATSUMURA TSUTOMU [JP]; ARAI HITOSHI [JP]; SASAKI KATSUTOSHI [JP]; KOBATAKE CHOEI [JP]; TSUKUMO YUKIHITO [JP]; IIDA KYOICHIRO [JP]; KUBOYAMA TAKESHI [JP]; MANABE HARUHIKO [JP]


Application No.: US20060252778A1  Published: 09/Nov/2006

Title: Compounds for the treatment of inflammatory disorders

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/142601   Filing Date: 01/Jun/2005

Abstract:This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-alpha or combinations thereof.

Priority: US20040576153P Applic. Date: 2004-06-02

Inventor: GUO ZHUYAN [US]; ORTH PETER [US]; ZHU ZHAONING [US]; MAZZOLA ROBERT D [US]; CHAN TIN-YAU [US]; VACCARO HENRY A [US]; MCKITTRICK BRIAN [US]; KOZLOWSKI JOSEPH A [US]; LAVEY BRIAN J [US]; ZHOU GUOWEI [US]; PALIWAL SUNIL [US]; WONG SHING-CHUN [US]; SHIH NENG-YANG [US]; TING PAULINE C [US]; ROSNER KRISTIN E [US]; SHIPPS GERALD W JR [US]; SIDDIQUI M A [US]; BELANGER DAVID B [US]; DAI CHAOYANG [US]; LI DANSU [US]; GIRIJAVALLABHAN VINAY M [US]; POPOVICI-MULLER JANETA [US]; YU WENSHENG [US]; ZHAO LIANYUN [US]


Application No.: US20060252813A1  Published: 09/Nov/2006

Title: Apparatus for curing a composite laminate

Applicant/Assignee:

Application No.: 10/540013   Filing Date: 22/Jun/2005

Abstract:The present invention is related to a compound of formula (I): A-B-E-D (I), wherein: A is selected from the group consisting R-L1-K-L2

and (II) B is either present or absent, but if B is present then B is (III), E is (IV), D is selected from the group comprising -(CR<1>R)rC(O)H, -(CR<1>R)rC-N, -CR<1>R)rNHNHC(O)NR<5>R<6>, -(CR<1>R)rC(O)(CRR)rc(O)OR<7>, -(CR<1>R)rC(O)(CrR)rC(O)NR<8>R<9>, -(CR<1>R)rCH(OH)(CrnR)rC(O)U, -(CR<1>R)rC(O)W-(CR<1>R)rC(O)CH2W, -(CR<1>R)rC(O)haloalkyl, and -(CR<1>R)rC(O)(CRR)r-CHN2, and the use of said compounds as an inhibitor to rotamases.

Priority: EP20020028699 Applic. Date: 2002-12-23; WO2003EP14844 Applic. Date: 2003-12-23

Inventor: KNOLLE JOCHEN [DE]; SCHUMTKOWSKI MIKE [DE]; HUMMEL GERD [DE]; TRADLER THOMAS [DE]; JOBRON LAURENCE [DE]; CHRISTNER CLAUDIA [DE]; STRAGIES ROLAND [DE]


Application No.: US20060252834A1  Published: 09/Nov/2006

Title: Hydroxamic acid derivatives and the method for preparing thereof

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 10/595124   Filing Date: 26/Aug/2004

Abstract:The present invention provides hydroxamic acid derivatives represented by the following formula (I), having anti-aging efficacy and a method for preparation thereof: wherein, R1 is herein, R5 and R6 each independently represents a hydrogen atom, a C1-C10 alkyl group or a C3-C6 cyclic alkyl group

R2 is CONH, NHCO, CONR7 or NR7CO, herein, R7 represents a C1-C10 alkyl group

R3 is -(CH)n-, herein, n=0 or 1

and R4 is a hydrogen atom or a C1-C10 alkyl group. Further, the present invention provides skin-care external compositions for preventing skin aging, containing said hydroxamic acid derivatives represented by the formula (I) as an active ingredient.

Priority: KR20030059177 Applic. Date: 2003-08-26; KR20040020401 Applic. Date: 2004-03-25; KR20040054886 Applic. Date: 2004-07-14; WO2004KR02143 Applic. Date: 2004-08-26

Inventor: RHO HO-SIK [KR]; BAEK HEUNG-SOO [KR]; KIM SU-JONG [KR]; KIM SU-NAM [KR]; CHAE BYUNG-GEUN [KR]; LEE BYOUNG-SEOK [KR]; KIM BAE-HWAN [KR]; CHOI GYU-HO [KR]; SON EUI-DONG [KR]; LEE HAE-KWANG [KR]; LEE HYE-WON [KR]; CHO JUN-CHEOL [KR]; KIM DUCK-HEE [KR]; CHANG IH-SEOP [KR]; LEE OK-SUB [KR]


Application No.: US20060252838A1  Published: 09/Nov/2006

Title: Use of spermine and/or spermidine against skin ageting in dietary, pharmaceuetical or cosmetic compositions

Applicant/Assignee:

Application No.: 10/566411   Filing Date: 30/Jul/2004

Abstract:The invention concerns the use of spermine and spermidine as active ingredients in the preparation of a composition for dietary, pharmaceutical or cosmetic use in humans for health and beauty of the skin and skin appendages, and related compositions for pharmaceutical or dietary or cosmetic use for administration to humans.

Priority: IT2003MI01570 Applic. Date: 2003-07-31; WO2004EP08572 Applic. Date: 2004-07-30

Inventor: RINALDI FABIO [IT]; SORBELLINI ELISABETTA [IT]; BARONI SERGIO [IT]; BENEDUSI ANNA [IT]


Application No.: US20060252839A1  Published: 09/Nov/2006

Title: Pharmaceutical compositions

Applicant/Assignee: CRAWFORD HEALTHCARE HOLDINGS LIMITED

Application No.: 10/957242   Filing Date: 27/Sep/2004

Abstract:A compound comprising a cyclopentanone, cyclopentenone, cyclohexanone or cyclohexenone group, wherein a first ring carbon atom carries an -SR substituent, R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group that, optionally, includes at least one heteroatom in its carbon skeleton, the remaining available ring carbon atoms are optionally substituted, and said compound either:-(a) is more soluble in water at a temperature of 20-40 DEG C.

(b) is less lipophilic

and/or, (c) has a greater therapeutic index

or

(d) is less soluble in water at a temperature of 20-40 DEG C.

(e) is more lipophilic

and/or, (f) has a greater therapeutic index

than an equivalent cyclohex-2-en-1-one or cyclopent-2-en-1-one derivative in which a hydrogen atom replaces said -SR group.

Priority: GB20020007232 Applic. Date: 2002-03-27; WO2002GB05708 Applic. Date: 2002-12-16; WO2002GB05709 Applic. Date: 2002-12-16

Inventor: ROBERTS STANLEY M [GB]; SANTORO MARIA GABRIELLA [IT]; JADHAV VASUDEV [GB]; HAPPE ALAN M [GB]; EVANS PAUL [GB]; ROSS NICOLETTE C [US]; SNAPE TIMOTHY J [GB]


Application No.: US20060252981A1  Published: 09/Nov/2006

Title: Biocompatible implant and use of the same

Applicant/Assignee:

Application No.: 10/537678   Filing Date: 05/Dec/2003

Abstract:The present invention provides an implant capable of being cellularized in treatment of an injured organ or tissue in organisms. The present inventors found that a biocompatible implant comprising a biological molecule and a support is capable of being cellularized. The implant can be used instead of conventional implants which essentially comprise cells. The present invention provides a biocompatible implant comprising A) a biological molecule and B) a support. The present invention also provides A) a first layer having a rough surface, B) a rough surface

B) a second layer having a strength which allows the support to resist in vivo shock. The first layer is attached to the second layer via at least one point.

Priority: JP20020354342 Applic. Date: 2002-12-05; JP20030320491 Applic. Date: 2003-09-11; WO2003JP15641 Applic. Date: 2003-12-05

Inventor: MATSUDA HIKARU [JP]; SAWA YOSHIKI [JP]; TAKETANI SATOSHI [JP]; IWAI SHIGEMITSU [JP]; HIRAKAWA KOICHIRO [JP]


Application No.: US20060253079A1  Published: 09/Nov/2006

Title: Stratum corneum piercing device

Applicant/Assignee:

Application No.: 11/113952   Filing Date: 25/Apr/2005

Abstract:The present invention features a stratum corneum-piercing device including a microprotrusion member having a skin-contacting surface and plurality of stratum corneum piercing microprotrusions thereon, the device being adapted to move the microprotrusion member lateral to the surface of the skin surface upon contact with the skin.

Priority: US2005-113890 Applic. Date: 2005-04-25; US2005-113937 Applic. Date: 2005-04-25; US2006-409454 Applic. Date: 2006-04-21

Inventor: MCDONOUGH JUSTIN [US]; LIU JUE-CHEN [US]; SUN YING [US]; LAMBINO DANILO [AU]; WU JEFFREY M [US]; MAGHRIBI MARIAM [US]


Application No.: US20060257336A1  Published: 16/Nov/2006

Title: Cosmetic composition comprising silica particles, reflecting particles, and at least one polymer, preparative processes, and uses thereof

Applicant/Assignee:

Application No.: 11/406371   Filing Date: 19/Apr/2006

Abstract:Disclosed herein is a cosmetic skin make-up and/or care composition comprising an oily phase, for example, a gelled or structured oily phase, comprising silica particles and reflecting particles, said oily phase comprising at least one polymer having a weight-average molecular weight of less than 100,000, for example, below 50,000, comprising (a) a polymer skeleton comprising hydrocarbon repeat units including at least one heteroatom, and (b) optionally at least one pendant fatty chain and/or at least one terminal fatty chain which may be optionally functionalized, comprise from 6 to 120 carbon atoms and which are bonded to the hydrocarbon repeat units. Also disclosed herein is a process for the preparation of this cosmetic composition, to a gloss comprising this cosmetic composition and to a method for obtaining a glossy deposit comprising applying this cosmetic composition to a substrate.

Priority: FR20050003895 Applic. Date: 2005-04-19; US20050675455P Applic. Date: 2005-04-28

Inventor: FERRARI VERONIQUE [FR]; KHACHIKIAN HELENE [FR]


Application No.: US20060257402A1  Published: 16/Nov/2006

Title: Use of soluble cd164 in inflammatory and/or autoimmune disorders

Applicant/Assignee: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V

Application No.: 10/565741   Filing Date: 23/Jul/2004

Abstract:The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of humans CD164, in particular for treating inflammatory and/or autoimmune disorders.

Priority: EP20030077316 Applic. Date: 2003-07-23; WO2004EP51596 Applic. Date: 2004-07-23

Inventor: CHVATCHKO YOLANDE [CH]


Application No.: US20060257502A1  Published: 16/Nov/2006

Title: A COMBINATION OF MITOCHONDRIAL NUTRIENTS FOR RELIEVING STRESS, PREVENTING AND IMPROVING STRESS-RELATED DISORDERS

Applicant/Assignee:

Application No.: 10/908425   Filing Date: 11/May/2005

Abstract:A dietary supplement of mitochondrial nutrients is designed for relieving stress, preventing and improving stress-related disorders, such as chronic fatigue syndrome, diabetes, age-associated cognitive dysfunction and diseases (Parkinson's and Alzheimer's disease). The supplement composition has the following nutrients: B vitamins (cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, Pantothenate 5-150 mg, folic acid 400-40,000 ug), alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000 mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg, all of which have been individually used experimentally or clinically for relieving stress, preventing and treating age- and stress-related disorders and diseases but no combination of these compounds has been used. Many embodiments also contain at least one adjunct ingredient such as coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

Priority:

Inventor: LIU JIANKANG [US]


Application No.: US20060257869A1  Published: 16/Nov/2006

Title: Short peptides from the '2nd loop' of 7 transmembrane receptor which selectively modulate signal transduction

Applicant/Assignee: CHILDREN'S HOSPITAL YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM

Application No.: 10/526533   Filing Date: 03/Sep/2003

Abstract:The present invention concerns compounds comprising, within short sequences from a specific regions of the 7TM receptor, that can modulate 7TM receptor-associated signal. The present invention further concerns methods for stimulation angiogenesis by administration of peptides derived from the EDG3 7TM-receptor.

Priority: US20020407290P Applic. Date: 2002-09-03; WO2003US27332 Applic. Date: 2003-09-03

Inventor: BEN-SASSON SHMUEL [IL]; REUVENI HADAS [IL]


Application No.: US20060258624A1  Published: 16/Nov/2006

Title: Composition and method for reducing the appearance of cellulite

Applicant/Assignee:

Application No.: 11/408383   Filing Date: 21/Apr/2006

Abstract:A topical composition for controlling the metabolism and/or distribution of subcutaneous fat and/or moderating the appearance of cellulite, comprising, as an active ingredient, phosphatidylcholine together with a solvent operative to maintain the phosphatidylcholine in solution, and a buffer which maintains the composition in the range of pH 7.5-9.0. Typically, the composition includes less than 10% by weight water. The composition may include further active ingredients such as xanthines. Also disclosed are methods for using the composition.

Priority: US20050674861P Applic. Date: 2005-04-26

Inventor: KULESZA JOHN [US]


Application No.: US20060258626A1  Published: 16/Nov/2006

Title: Use of inositol-tripyrophosphate in treating tumors and diseases

Applicant/Assignee:

Application No.: 11/396338   Filing Date: 31/Mar/2006

Abstract:Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

Priority: US2005-175979 Applic. Date: 2005-07-06; US2006-384012 Applic. Date: 2006-03-17; US20040585804P Applic. Date: 2004-07-06; US20050663491P Applic. Date: 2005-03-18

Inventor: NICOLAU CLAUDE [US]; GREFERATH RUTH [DE]; LEHN JEAN-MARIE [FR]; FYLAKTAKIDOU KONSTANTINA C [GR]


Application No.: US20060258661A1  Published: 16/Nov/2006

Title: 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/557171   Filing Date: 17/Nov/2005

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression,

premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030483675P Applic. Date: 2003-06-30; WO2004US20539 Applic. Date: 2004-06-25

Inventor: WILLIAM P DANKULICH [US]; KAUFMAN MILDRED L [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20060258665A1  Published: 16/Nov/2006

Title: Bridged ring NK1 antagonists

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/291363   Filing Date: 01/Dec/2005

Abstract:A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Priority: US20040635971P Applic. Date: 2004-12-14

Inventor: XIAO DONG [US]; PALANI ANANDAN [US]; WANG CHENG [US]; TSUI HON-CHUNG [US]; HUANG XIANHAI [US]; SHAH SAPNA S [US]; RAO ASHWIN U [US]; CHEN XIAO [US]; PALIWAL SUNIL [US]; SHIH NENG-YANG [US]


Application No.: US20060258694A1  Published: 16/Nov/2006

Title: HISTONE DEACETYLASE INHIBITORS

Applicant/Assignee: TAKEDA SAN DIEGO, INC

Application No.: 11/382659   Filing Date: 10/May/2006

Abstract:Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Priority: US20050679923P Applic. Date: 2005-05-11

Inventor: BRESSI JEROME C [US]; BROWN JASON W [US]; GANGLOFF ANTHONY R [US]; STAFFORD JEFFREY A [US]; VU PHONG H [US]


Application No.: US20060258753A1  Published: 16/Nov/2006

Title: Steroid derivatives and use thereof as medicaments

Applicant/Assignee: INOVAT

Application No.: 10/567590   Filing Date: 23/Jul/2004

Abstract:Steroids of the formula wherein R is defined as in the application capable of increasing the synthesis of collagen.

Priority: FR20030009099 Applic. Date: 2003-07-25; WO2004FR01990 Applic. Date: 2004-07-23

Inventor: GUTIERREZ GILLES [FR]; HADID ZOHRA [FR]


Application No.: US20060258768A1  Published: 16/Nov/2006

Title: Compositions comprising a dispersant and microcapsules containing an active material

Applicant/Assignee:

Application No.: 11/487549   Filing Date: 14/Jul/2006

Abstract:Compositions for providing controlled-release of an active material comprise a dispersant and microcapsules containing the active material. The compositions contain the dispersant and/or microcapsules at relatively low levels to avoid negatively impacting the surfaces treated with the compositions. The active material is preferably a perfume and the composition provides a controlled-release scent, along with controlling malodor when the compositions fuirther comprise optional odor control agent. Methods of providing a controlled-release of an active material on a surface comprise the step of contacting the surface with a composition comprising a dispersant and microcapsules containing an active material.

Priority: US2003-405678 Applic. Date: 2003-04-02; US20020373439P Applic. Date: 2002-04-18

Inventor: UCHIYAMA HIROTAKA [US]; CETTI JONATHAN R [US]; ALONSO MARIO [US]; MONTEZINOS DAVID L [US]; COBB DANIEL S [US]


Application No.: US20060258884A1  Published: 16/Nov/2006

Title: 4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 10/562698   Filing Date: 02/Jul/2004

Abstract:4-(methylsulfonylamino)phenyl analogues as potent vanilloid receptor antagonists and pharmaceutical compositions comprising the same. The compounds are useful as analgesics to prevent, alleviate or treat pain diseases or inflammatory disease including pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.

Priority: KR20030044552 Applic. Date: 2003-07-02; WO2004KR01641 Applic. Date: 2004-07-02

Inventor: LEE JEE W [KR]; KIM HEE [KR]; CHOI HYUN K [KR]; HA HEE J [KR]


Application No.: US20060259995A1  Published: 16/Nov/2006

Title: Proteases, nucleic acids encoding them and methods for making and using them

Applicant/Assignee: DIVERSA CORPORATION

Application No.: 10/530643   Filing Date: 10/Oct/2003

Abstract:The invention is directed to polypeptides having protease activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of diagnostic, therapeutic, and industrial contexts. The polypeptides of the invention can be used as, e.g., an additive for a detergent, for processing foods and for chemical synthesis utilizing a reverse reaction.

Additionally, the polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to ethanol diodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in increasing starch yield from corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.

Priority: US20020418467P Applic. Date: 2002-10-10; US20030471423P Applic. Date: 2003-05-16; WO2003US32819 Applic. Date: 2003-10-10

Inventor: CAYOUETTE MICHELLE [US]; HANSEN CONNIE J [US]; MCCLURE AMY [US]; SUN MAY [US]; GRAMATIKOVA SVETLANA [US]; DYCAICO MARK [US]; BARTON NELSON R [US]; STEGE JUSTIN T [US]; ABOUSHADI NAHLA M [US]


Application No.: US20060263309A1  Published: 23/Nov/2006

Title: Regulation of mammalian keratinous tissue using personal care compositions comprising tetrahydrocurcumin

Applicant/Assignee:

Application No.: 11/396738   Filing Date: 03/Apr/2006

Abstract:Personal care compositions containing tetrahydrocurcumin alone, or in combination with tetrahydromethoxycurcumin and/or tetrahydrobisdemethoxycurcumin are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US20050681626P Applic. Date: 2005-05-17; US20050701370P Applic. Date: 2005-07-21

Inventor: BISSETT DONALD L [US]


Application No.: US20060263320A1  Published: 23/Nov/2006

Title: Regulation of mammalian keratinous tissue using personal care compositions comprising ergothioneine

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/406471   Filing Date: 18/Apr/2006

Abstract:Personal care compositions containing ergothioneine are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US20050681626P Applic. Date: 2005-05-17

Inventor: BISSETT DONALD L [US]


Application No.: US20060263321A1  Published: 23/Nov/2006

Title: Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/406477   Filing Date: 18/Apr/2006

Abstract:Personal care compositions containing diethylhexyl syringylidene malonate are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US20050681626P Applic. Date: 2005-05-17

Inventor: BISSETT DONALD L [US]


Application No.: US20060263340A1  Published: 23/Nov/2006

Title: Treating gastrointestinal diseases with modulators of retinoic acid

Applicant/Assignee:

Application No.: 11/413874   Filing Date: 28/Apr/2006

Abstract:T cells are programmed to target the gastrointestinal tract by activation with dendritic cells capable of producing and/or transporting retinoic acid. Methods for using the programmed dendritic cells and/or T and/or B cells to treat a variety of pathogens and infectious agents residing in the intestine are also disclosed. Similarly, inhibitors of retinoic acid synthesis by dendritic cells or other cells in the gut, and inhibitors of retinoic acid receptors in T and/or B cells or other cells in the intestinal mucosa, are disclosed for treating a variety of gastrointestinal autoimmune diseases such as inflammatory bowel disease and celiac disease.

Priority: US20050676249P Applic. Date: 2005-04-29

Inventor: ANDRIAN ULRICH H V [US]; MORA RODRIGO [US]


Application No.: US20060263438A1  Published: 23/Nov/2006

Title: Gelled oil particles for targeting sebaceous glands and/or hair follicles

Applicant/Assignee: L'OREAL

Application No.: 11/434828   Filing Date: 17/May/2006

Abstract:The present invention relates to calibrated and spherical oily particles comprising at least one oily phase structured with at least one gelling polymer, characterized in that they have a mean size of less than or equal to 15 mum, in that the said structured oily phase has a melting point of greater than or equal to 40 DEG C. and in that their circularity index is between 0.9 and 1.

Priority: FR20050051275 Applic. Date: 2005-05-17; US20050688323P Applic. Date: 2005-06-08

Inventor: BIATRY BRUNO [FR]; SIMONNET JEAN-THIERRY [FR]


Application No.: US20060263774A1  Published: 23/Nov/2006

Title: Compositions and methods for the treatment of immune related diseases

Applicant/Assignee: GENENTECH, INC

Application No.: 10/533519   Filing Date: 30/Oct/2003

Abstract:The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US20020423394P Applic. Date: 2002-11-01; WO2003US34312 Applic. Date: 2003-10-30

Inventor: CLARK HILARY [US]; SCHOENFELD JILL R [US]; VANLOOKEREN MENNO [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]; WU THOMAS D [US]


Application No.: US20060263827A1  Published: 23/Nov/2006

Title: Novel endothelial cells, antibodies directed against said cells and use thereof, in particular for screening angiogenesis inhibiting substances

Applicant/Assignee:

Application No.: 10/530893   Filing Date: 10/Oct/2003

Abstract:The invention concerns the use of a binary set comprising: endothelial cells of non-angiogenic phenotype and endothelial cells of angiogenic phenotype, for screening substances angiogenic towards endothelial cells of non-angiogenic phenotype, not substantially affecting substantially the of angiogenic phenotype endothelial cells of angiogenic phenotype, or substances angiogenic towards endothelial cells of angiogenic phenotype, not affecting substantially the endothelial cells of non-angiogenic phenotype.

Priority: FR20020012606 Applic. Date: 2002-10-10; WO2003FR02996 Applic. Date: 2003-10-10

Inventor: PLOUET JEAN P [FR]; PEDRON SANDRINE F [FR]; BOUBE MAITRE [FR]


Application No.: US20060264344A1  Published: 23/Nov/2006

Title: Mild foaming cleansing composition

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/135243   Filing Date: 23/May/2005

Abstract:A foaming mild liquid cleansing composition that is dispensed as a mousse or foam is described that contains very low levels of surfactant and that can be conveniently wiped off the skin while depositing significant amounts of skin conditioning compounds. In a preferred embodiment, the composition is provided as a transparent microemulsion.

Priority:

Inventor: GOLDBERG JESSICA W [US]; LAGATOL SHAUNA M [US]; PADLO EWA U [US]


Application No.: US20060264345A1  Published: 23/Nov/2006

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee:

Application No.: 11/432006   Filing Date: 11/May/2006

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain sterically hindered amine salt compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US20050682233P Applic. Date: 2005-05-18

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MERVIN G [US]; MARTIN WANDA H [US]


Application No.: US20060264364A1  Published: 23/Nov/2006

Title: Acetylated therapeutic procytotoxins

Applicant/Assignee: GREENVILLE HOSPITAL SYSTEM GHC RESEARCH DEVELOPMENT CORPORATION

Application No.: 11/131443   Filing Date: 18/May/2005

Abstract:A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group, and an acetyl group. These agents are useful in treating cancer, especially prostate cancer.

Priority:

Inventor: WAGNER THOMAS E [US]; YU XIANZHONG [US]


Application No.: US20060264480A1  Published: 23/Nov/2006

Title: Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same

Applicant/Assignee:

Application No.: 11/373828   Filing Date: 13/Mar/2006

Abstract:The present invention relates to an antagonist against vanilloid receptor and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fevescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

Priority: KR20000048387 Applic. Date: 2000-08-21; US2003-343703 Applic. Date: 2003-02-03; WO2001KR01409 Applic. Date: 2001-08-20

Inventor: SUH YOUNG G [KR]; OH UH T [KR]; KIM HEE D [KR]; LEE JEE W [KR]; PARK HYEUNG G [KR]; PARK YOUNG H [KR]; YI JUNG B [KR]


Application No.: US20060264504A1  Published: 23/Nov/2006

Title: Treatment of cell-mediated immune diseases

Applicant/Assignee:

Application No.: 11/432965   Filing Date: 12/May/2006

Abstract:9-cis retinoic acid and pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, 9-cis retinal and pharmaceutically acceptable acetals thereof, and 9-cis retinol and pharmaceutically acceptable hydrolyzable esters thereof as well as metabolites of 9-cis retinoic acid have been found to be efficacious in treating T-helper cell type 1 mediated immune diseases in well tolerated doses. Preferably, the active ingredient is formulated as a medicament for oral or topical administration.

Priority: US2003-459273 Applic. Date: 2003-06-11; US2000-485943 Applic. Date: 2000-04-07

Inventor: BOLLAG WERNER [CH]; OTT FRITZ [CH]


Application No.: US20060264505A1  Published: 23/Nov/2006

Title: Dermatological compositions

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 11/493589   Filing Date: 27/Jul/2006

Abstract:Topical dermatological compositions comprising urea as an active ingredient, a vegetable oil or a derivative thereof, water, and conventional excipients. These compositions are used for topical medical applications, particularly to treat various skin disorders.

Priority: US2003-702782 Applic. Date: 2003-11-07

Inventor: POPP KARL F [US]; SANTELLI RONALD J [US]


Application No.: US20060264515A1  Published: 23/Nov/2006

Title: Compounds, formulations, and methods for ameliorating telangiectasias

Applicant/Assignee: SANSROSA PHARMACEUTICAL DEVELOPMENTS, INC GALDERMA LABORATORIES INC

Application No.: 11/449079   Filing Date: 08/Jun/2006

Abstract:Methods, compounds, and topical formulations for treatment of telangiectasias are disclosed. The methods comprise topically applying a composition comprising an alpha-adrenergic receptor agonist to telangiectatic skin. Amelioration of telangiectasia symptoms begins within minutes after topical application of a disclosed composition. A single application can significantly lessen telangiectasia discoloration for at least about 2 hours.

Priority: US2004-853585 Applic. Date: 2004-05-25; US20030473611P Applic. Date: 2003-05-27

Inventor: DEJOVIN JACK A [US]; DEJOVIN ISABELLE J [US]; POWALA CHRISTOPHER [US]


Application No.: US20060264524A1  Published: 23/Nov/2006

Title: Polyurethane foams comprising oligomeric polyols

Applicant/Assignee: CARGILL, INCORPORATED

Application No.: 11/411357   Filing Date: 25/Apr/2006

Abstract:The invention relates to polyurethane foams comprising oligomeric polyols. In embodiments of the invention, the polyurethane foams comprise the reaction product of: (a) a polyisocyanate

and (b) an active-hydrogen containing composition comprising an oligomeric polyol having a hydroxyl number of about 45 to about 65 mg KOH/g, a number average hydroxyl functionality (Fn) of less than about 2.7, and about 40% weight or greater oligomers. The polyurethane foams of the invention may be slabstock foams or molded foams. Also disclosed are low odor polyols and polyurethane compositions.

Priority: US20050674879P Applic. Date: 2005-04-25; US20050677272P Applic. Date: 2005-05-02; US20050741123P Applic. Date: 2005-12-01; US20060786594P Applic. Date: 2006-03-27

Inventor: ABRAHAM TIMOTHY W [US]; CARTER JACK A [US]; DOUNIS DIMITRI [US]; MALSAM JEFF [US]


Application No.: US20060264804A1  Published: 23/Nov/2006

Title: Device and kit for delivery of encapsulated substances and methods of use thereof

Applicant/Assignee:

Application No.: 11/397864   Filing Date: 05/Apr/2006

Abstract:The present invention is of a kit and electricity generating device for delivery of an encapsulated composition or mixture of compositions, including an electricity generating device and at least one composition in an encapsulated carrier vehicle which is contacted or applied to the electricity generating device. In some embodiments the device includes a means for maintaining stability of the encapsulated composition prior to bio-membrane penetration. The present invention also provides methods of use thereof. Furthermore, the present invention provides a device and method for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of a device and method for delivering each compound of a mixture of compounds to the same penetration depth.

Priority: US20050669001P Applic. Date: 2005-04-07

Inventor: KARMON YORAM [IL]; HAREL NURIT [IL]; MAVOR DANIELA [IL]; SHAHAR MICHAL [IL]


Application No.: US20060265029A1  Published: 23/Nov/2006

Title: Apparatus and methods for using self-heating chamber to excite a multi-compound TDP layer to generate infrared wavelength for various pain treatment, and composition of this TDP layer

Applicant/Assignee: TCM GROUPS INC

Application No.: 11/134976   Filing Date: 23/May/2005

Abstract:An apparatus, product formulation, and method for using heat to excite a multi-compound layer to generate infrared wavelength, wherein the apparatus includes 1) a multi-compound TDP layer which can be excited by heat to generate infrared wavelength and 2) a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The TDP layer is composed of more than 30 compounds including ZrO, SiO2, SiC2, Al2O3, FeO, MnO2, Cu2O, MgO, ZnO, and Cr2O3. The heat-generating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water, and/or salt, which is activated upon contact with air (oxygen). The heat can last as long as 16 hours. The function of the heat-generating element is to supply energy to excite TDP multi-compound layer to generate infrared wavelength at 2-18 micrometer (especially at 4-14 micrometer) range, for all types of pain treatment. The apparatus may also include a layer contacting user's skin to store active pharmaceuticals and transdermal system to additionally relieve pain and improve symptoms associated with arthritis, soft tissue damage, neck vertebrate pain, lumber muscle strain, lumber intervertebrate disc herniation, arthritis around shoulder, prostate inflammation, pelvic inflammation, pain of bone hyperplasia, gastroenteritis, and dysmenorrhoea.

Priority:

Inventor: HUANG LAN [US]; WU JILUN [CN]


Application No.: US20060269485A1  Published: 30/Nov/2006

Title: Antibiotic kit and composition and uses thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/448490   Filing Date: 07/Jun/2006

Abstract:The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product

and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent

at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water

and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20050688244P Applic. Date: 2005-06-07

Inventor: FRIEDMAN DORON [IL]; BESONOV ALEX [IL]; TAMARKIN DOV [IL]; EINI MEIR [IL]


Application No.: US20060269489A1  Published: 30/Nov/2006

Title: Depilatory compositions

Applicant/Assignee:

Application No.: 11/138110   Filing Date: 26/May/2005

Abstract:The present invention is directed to dual phase and single phase depilatory compositions and methods of using said compositions. More specifically, the present invention is directed to a dual phase composition for the removal of hair comprising a first acidic phase containing a thiol-based depilatory agent and a second alkaline phase containing a pH buffer. The present invention is also directed to a single phase depilatory composition comprising 2-aminoehtanethiol and a pH buffer and an advantageous packaging means for said single phase depilatory composition.

Priority:

Inventor: ADAMY STEVEN T [US]


Application No.: US20060269495A1  Published: 30/Nov/2006

Title: Alpha hydroxy acid compositions

Applicant/Assignee:

Application No.: 11/136458   Filing Date: 25/May/2005

Abstract:Pharmaceutical compositions suitable for topical administration comprising an alpha hydroxy acid. In a particular aspect, these compositions exhibit improved tolerance on the skin upon topical application despite the presence of high levels of alpha hydroxy acids in the composition. These compositions are used for topical medical applications, particularly to treat various skin disorders.

Priority:

Inventor: POPP KARL F [US]; CLARK KATHLEEN L [US]


Application No.: US20060269501A1  Published: 30/Nov/2006

Title: Shampoo containing a gel network

Applicant/Assignee:

Application No.: 11/475484   Filing Date: 27/Jun/2006

Abstract:Shampoo compositions comprise (a) from about 5% to about 50% of one or more detersive surfactants, by weight of the shampoo composition

(b) a dispersed gel network phase comprising, by weight of the shampoo composition, (i) at least about 0.05% of one or more fatty alcohols

(ii) at least about 0.01% of one or more secondary surfactants

and (iii) water

and (c) at least about 20% of an aqueous carrier, by weight of the shampoo composition

and, wherein the dispersed gel network phase has a melt transition temperature of at least about 38 DEG C. A process for preparing a shampoo composition comprises the steps of: (a) combining a fatty alcohol, a secondary surfactant, and water at a temperature sufficient to allow partitioning of the secondary surfactant and the water into the fatty alcohol to form a pre-mix

(b) cooling the pre-mix below the chain melt temperature of the fatty alcohol to form a gel network

(c) adding the gel network to one or more detersive surfactants and an aqueous carrier to form a shampoo composition which comprises a dispersed gel network phase having a melt transition temperature of at least about 38 DEG C.

Priority: US2005-228770 Applic. Date: 2005-09-16; US2003-454433 Applic. Date: 2003-06-04; US20020385641P Applic. Date: 2002-06-04

Inventor: JOHNSON ERIC S [US]; HILVERT JENNIFER E [US]; HEATH BENJAMIN P [US]; COOPER SARAH E [US]


Application No.: US20060269502A1  Published: 30/Nov/2006

Title: Shampoo containing a gel network and a non-guar galactomannan polymer derivative

Applicant/Assignee:

Application No.: 11/475485   Filing Date: 27/Jun/2006

Abstract:Shampoo compositions comprise (a) from about 5% to about 50% of one or more detersive surfactants

(b) a dispersed gel network phase comprising: (i) at least about 0.05% of one or more fatty amphiphiles

(ii) at least about 0.01% of one or more secondary surfactants

and (iii) water

(c) at least about 0.05% of a galactomannan polymer derivative with a net positive charge and having a mannose to galactose ratio of greater than 2 : 1 on a monomer to monomer basis, wherein the galactomannan polymer derivative has: (i) a molecular weight from about 1,000 to about 10,000,000

and (ii) a cationic charge density from about 0.7 meq/g to about 7 meq/g

and (d) at least about 20% of an aqueous carrier

all by weight of the shampoo composition.

Priority: US2005-228770 Applic. Date: 2005-09-16; US2003-454433 Applic. Date: 2003-06-04; US20020385641P Applic. Date: 2002-06-04

Inventor: JOHNSON ERIC S [US]; HILVERT JENNIFER E [US]; HEATH BENJAMIN P [US]; COOPER SARAH E [US]


Application No.: US20060269505A1  Published: 30/Nov/2006

Title: Detergent composition

Applicant/Assignee: CONOPCO, INC

Application No.: 10/543473   Filing Date: 23/Jan/2004

Abstract:A cleansing cosmetic composition comprising

i) a cationised silicon delivery system selected from one or more of a) a cationised fatty alkyl silicone copolymer

b) a cationised dimethiconol complex and c) a cationised high viscosity lower alkyl silicone fluid with or without cationised silicone gum blend

and ii) detergent active. Also disclosed is a cationised silicone delivery system comprising: a) 15-50 parts of a cationised fatty alkyl silicone copolymer

b) 5-50 parts of a cationised dimethiconol complex

and c) 1-50 parts of a cationised high viscosity lower alkyl silicone fluid with cationised silicone gum blend.

Priority: IN2003MU00108 Applic. Date: 2003-01-29; IN2003MU00109 Applic. Date: 2003-01-29; GB20030009017 Applic. Date: 2003-04-22; GB20030010786 Applic. Date: 2003-05-12; WO2004EP00662 Applic. Date: 2004-01-23

Inventor: PAUL SUDIPTO K [IN]; RAMACHANDRAN KIZHAKERA N [IN]


Application No.: US20060269506A1  Published: 30/Nov/2006

Title: Personal care applications of emulsions containing elastomeric silanes and siloxanes with nitrogen atoms

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 10/552537   Filing Date: 15/Apr/2004

Abstract:Oil-in-water (O/W) and water-in-oil (W/O) emulsions and microemulsions containing elastomeric silanes or siloxanes preferably having quaternary ammonium groups are generally made by reacting organic quaternary ammonium compounds having epoxide groups or halohydrin groups, with silanes or siloxanes having amino groups. The reaction is carried out in an aqueous polar phase containing a crosslinking agent and surfactant. The emulsions and microemulsions are especially useful for treating hair, skin, or the underarm.

Priority: US20030471059P Applic. Date: 2003-05-16; WO2004US11535 Applic. Date: 2004-04-15

Inventor: DE CAIRE JULIE S [US]; JOHNSON BETHANY [US]; LAFORE MICHAEL R [US]; LIN ZUCHEN [US]


Application No.: US20060269534A1  Published: 30/Nov/2006

Title: Feline probiotic bifidobacteria

Applicant/Assignee: THE IAMS COMPANY

Application No.: 11/443765   Filing Date: 31/May/2006

Abstract:According to the invention there is provided a strain of lactic acid bacteria of the genus Bifidobacteria obtainable by isolation from resected and washed feline gastrointestinal tract having a probiotic activity in animals. Methods of use and compositions comprising the Bifidobacteria of the present invention are also provided.

Priority: US20050692439P Applic. Date: 2005-06-21; US20050686016P Applic. Date: 2005-05-31

Inventor: BOILEAU THOMAS W [US]; KILEY BARRY P [IE]; O'MAHONY LIAM D [IE]; MACSHARRY JOHN [IE]; SUNVOLD GREG D [US]


Application No.: US20060269954A1  Published: 30/Nov/2006

Title: Self-assembling recombinant papillomavirus capsid proteins

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES DEUTSCHES KREBSFORSCHUNGSZENTRUM, THE GERMAN CANCER RESEARCH CENTER

Application No.: 11/450729   Filing Date: 09/Jun/2006

Abstract:Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

Priority: US2003-371846 Applic. Date: 2003-02-21; US2001-832065 Applic. Date: 2001-04-09; US1999-316487 Applic. Date: 1999-05-21; US1995-484503 Applic. Date: 1995-06-07; US1993-032869 Applic. Date: 1993-03-16; US1992-941371 Applic. Date: 1992-09-03

Inventor: LOWY DOUGLAS R [US]; SCHILLER JOHN T [US]; KIRNBAUER REINHARD [US]


Application No.: US20060270003A1  Published: 30/Nov/2006

Title: IL-17A/F heterologous polypeptides and therapeutic uses thereof

Applicant/Assignee: GENENTECH, INC

Application No.: 10/860824   Filing Date: 02/Jun/2004

Abstract:The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Priority: US20030486457P Applic. Date: 2003-07-11; US20030485599P Applic. Date: 2003-07-08

Inventor: ARNOTT DAVID P [US]; GURNEY AUSTIN L [US]; HASS PHILIP E [US]; LEE JAMES M [US]; WU YAN [US]


Application No.: US20060270016A1  Published: 30/Nov/2006

Title: Novel adenoviruses, nucleic acids that code for the same and the use of said viruses

Applicant/Assignee:

Application No.: 10/579543   Filing Date: 15/May/2006

Abstract:The present invention is related to an adenovirus expressing a first protein which is selected from the group comprising an E1B protein and an E4 protein, priorto a second protein which is selected from the group comprising an E1A protein.

Priority: DE20031053152 Applic. Date: 2003-11-14; DE200410018117 Applic. Date: 2004-04-14; WO2004EP12931 Applic. Date: 2004-11-15

Inventor: HOLM PER S [DE]


Application No.: US20060270020A1  Published: 30/Nov/2006

Title: Feline probiotic Lactobacilli

Applicant/Assignee: THE IAMS COMPANY

Application No.: 11/443974   Filing Date: 31/May/2006

Abstract:According to the invention there is provided a strain of lactic acid bacteria of the genus Lactobacilli obtainable by isolation from resected and washed feline gastrointestinal tract having a probiotic activity in animals. Methods of use and compositions comprising the Lactobacilli of the present invention are also provided.

Priority: US20050692440P Applic. Date: 2005-06-21; US20050686055P Applic. Date: 2005-05-31

Inventor: BOILEAU THOMAS W [US]; KILEY BARRY P [IE]; O'MAHONY LIAM D [IE]; MACSHARRY JOHN [IE]; SUNVOLD GREGORY D [US]


Application No.: US20060270040A1  Published: 30/Nov/2006

Title: Compositions and methods for treating tissue

Applicant/Assignee: CONJUGON, INC

Application No.: 11/137950   Filing Date: 26/May/2005

Abstract:The present invention relates to the field of bacteriology. In particular, the invention relates to novel compositions and methods for altering (e.g., inhibiting) the growth and virulence of populations of pathogenic microorganisms.

Priority:

Inventor: FILUTOWICZ MARCIN [US]; SUZUKI HIDEKI [US]


Application No.: US20060270614A1  Published: 30/Nov/2006

Title: Use of chalcones for the treatment of viral disorders

Applicant/Assignee:

Application No.: 11/137198   Filing Date: 24/May/2005

Abstract:The present invention relates to chalcone derivatives and compositions containing such derivatives useful in the treatment of viral disorders, including but not limited to the treatment of viral lesions resulting from viruses such as Herpes Simplex virus.

Priority:

Inventor: BODDUPALLI SEKHAR [US]; MAHMOOD KHALID [US]; SALIOU CLAUDE [US]


Application No.: US20060270676A1  Published: 30/Nov/2006

Title: Hydrazono-malonitriles

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 11/497235   Filing Date: 02/Aug/2006

Abstract:Hydrazono-malonitrile derivatives of the formula (I) in which R<1>, R<2>, R<3>, R<3'> and R<4 >have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

Priority: EP20010125455 Applic. Date: 2001-11-05; US2004-494631 Applic. Date: 2004-05-04; WO2002EP11351 Applic. Date: 2002-10-10

Inventor: EGGENWEILER HANS-MICHAEL [DE]; WOLF MICHAEL [DE]; BEIER NORBERT [DE]; SCHELLING PIERRE [DE]; EHRING THOMAS [DE]


Application No.: US20060270681A1  Published: 30/Nov/2006

Title: Pyridazine derivatives

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 11/497241   Filing Date: 02/Aug/2006

Abstract:Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

Priority: DE20021024888 Applic. Date: 2002-06-05; US2004-516876 Applic. Date: 2004-12-03; WO2003EP04930 Applic. Date: 2003-05-12

Inventor: EGGENWEILER HANS-MICHAEL [DE]; WOLF MICHAEL [DE]


Application No.: US20060270736A1  Published: 30/Nov/2006

Title: Ternary and quaternary eutectic mixtures of local anesthetics substances

Applicant/Assignee: CRISTALIA PRODUCTOS QUIMICOS FARMACEUTICOS LTDA

Application No.: 10/557737   Filing Date: 21/Nov/2005

Abstract:The present invention describes ternary and quaternary eutectic mixtures composed by active local anesthetic substances. These eutectic mixtures possess melting point inferior to 2O DEG C. and consist of homogeneous liquid useful in the preparation o pharmaceutical compositions for topical anesthesia or analgesia of tissues as skin or mucous.

Priority: BR20030001968 Applic. Date: 2003-05-22; WO2004BR00073 Applic. Date: 2004-05-21

Inventor: PACHECO OGARI [BR]; RUSSO ELISA [BR]; RUSSO VALTER [BR]; MARTINS JOSE A [BR]


Application No.: US20060275218A1  Published: 07/Dec/2006

Title: Foamable vehicle and pharmaceutical compositions thereof

Applicant/Assignee: FOAMIX LTD FOAMIX, LTD

Application No.: 11/430599   Filing Date: 09/May/2006

Abstract:A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG

0% to about 48% of a secondary polar solvent

about 0.2% to about 5% by weight of a surface-active agent

about 0.01% to about 5% by weight of at least one polymeric agent

and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2004-835505 Applic. Date: 2004-04-28; US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]


Application No.: US20060275221A1  Published: 07/Dec/2006

Title: Saccharide foamable compositions

Applicant/Assignee: FOAMIX LTD

Application No.: 11/430437   Filing Date: 09/May/2006

Abstract:A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]


Application No.: US20060275228A1  Published: 07/Dec/2006

Title: Skin care compositions containing idebenone

Applicant/Assignee:

Application No.: 11/408326   Filing Date: 21/Apr/2006

Abstract:A stable skin care composition, comprising an effective amount of idebenone, at least one additional skin care active, and a dermatologically acceptable carrier. The composition is substantially colorless.

Priority: US20050678967P Applic. Date: 2005-05-09

Inventor: BISSETT DONALD L [US]; ROBINSON LARRY R [US]; MITRA SHEKHAR [US]


Application No.: US20060275229A1  Published: 07/Dec/2006

Title: Skin care active complex and methods of using same

Applicant/Assignee:

Application No.: 11/436797   Filing Date: 17/May/2006

Abstract:A skin care active complex in accordance with an embodiment of the invention comprises a combination of (1) from about 0.001% to about 10% by weight, preferably from about 0.001% to about 5% by weight, of a vitamin A derivative

(2) from about 0.00001% to about 10% by weight of a hydroxamate derivative

(3) from about 0.01% to about 5% by weight of an anti-inflammatory natural compound

and optionally, (1) from about 0.001% to about 10% by weight of vitamin K.

Priority: US20050594908P Applic. Date: 2005-05-17

Inventor: PILLAI SREEKUMAR [US]; COSTELLO BRIAN [US]; ORESAJO CHRISTIAN [US]; CECCOLI JOSEPH [US]


Application No.: US20060275237A1  Published: 07/Dec/2006

Title: Skin care compositions containing idebenone

Applicant/Assignee:

Application No.: 11/408890   Filing Date: 21/Apr/2006

Abstract:A stable skin care composition, comprising an effective amount of idebenone, at least one additional skin care active, and a dermatologically acceptable carrier.

Priority: US20050678965P Applic. Date: 2005-05-09

Inventor: BISSETT DONALD L [US]; MITRA SHEKHAR [US]


Application No.: US20060275238A1  Published: 07/Dec/2006

Title: Topical cosmetic formulations for regulating and improving the moisture content of the skin

Applicant/Assignee: GOLDSCHMIDT GMBH

Application No.: 11/441659   Filing Date: 26/May/2006

Abstract:Cosmetic and/or dermatological formulations for the topical treatment of the skin for regulating and improving the moisture content of the skin, comprising as active ingredient combination a) at least one anionic polyamino acid matrix, b) at least one polysaccharide, and optionally c) one or more osmoprotectants for topical application are provided.

Priority: DE200510026069 Applic. Date: 2005-06-07

Inventor: BLASKO-BEGOIHN HEIKE [DE]; FARWICK MIKE [DE]; LERSCH PETER [DE]; MACZKIEWITZ URSULA [DE]; MECKING MARIA [DE]; SCHEUERMANN RALPH [DE]; WEITEMEYER CHRISTIAN [DE]


Application No.: US20060275239A1  Published: 07/Dec/2006

Title: Depolymerized scleroglucan for regulating and improving the moisture content of the skin

Applicant/Assignee: GOLDSCHMIDT GMBH

Application No.: 11/448953   Filing Date: 07/Jun/2006

Abstract:The use of depolymerized scleroglucan alone, or in combination with one or more active ingredients as a moisturizer, and as anti-inflammatory active ingredient for protecting and for restoring a healthy skin barrier in the field of cosmetic or dermatological skincare is disclosed.

Priority: DE200510026061 Applic. Date: 2005-06-07

Inventor: FARWICK MIKE [DE]; MACZKIEWITZ URSULA [DE]; MECKING MARIA [DE]; SCHICK GEORG [US]; WOLLENWEBER UTE [DE]


Application No.: US20060275294A1  Published: 07/Dec/2006

Title: METHOD OF PREVENTION AND TREATMENT OF AGING, AGE-RELATED DISORDERS AND/OR AGE-RELATED MANIFESTATIONS INCLUDING ATHEROSCLEROSIS, PERIPHERAL VASCULAR DISEASE, CORONARY ARTERY DISEASE, OSTEOPOROSIS, ARTHRITIS, TYPE 2 DIABETES, DEMENTIA, ALZHEIMERS DISEASE AND CANCER

Applicant/Assignee:

Application No.: 11/279239   Filing Date: 10/Apr/2006

Abstract:This invention relates to a method for prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, type 2 diabetes, dementia and some forms of arthritis and cancer in a subject comprising administering to said subject, separately, sequentially or simultaneously a therapeutically effective dosage of each component or combination of statins, bisphosphonates, cholesterol lowering agents or techniques, interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, serine/threonine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors/antibodies, Nuclear factor kappaB (NF-kappaB) inhibitors/antibodies, IkappaB kinase (IKK) inhibitors/antibodies, activator protein-1 (AP-1) inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof, administered separately, in sequence or simultaneously. Inhibition of the signal transduction pathway for Interleukin 6 mediated inflammation is key to the prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, aging, age-related disorders and/or age-related manifestations including osteoporosis, type 2 diabetes, dementia and some forms of arthritis and tumors. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway utilizing interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, serine/threonine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors/antibodies, Nuclear factor kappaB (NF-kappaB) inhibitors/antibodies, IkappaB kinase (IKK) inhibitors/antibodies, activator protein-1 (AP-1) inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism, isoprenoid depletion and/or inhibition of the signal transduction pathway

Priority: US2005-268609 Applic. Date: 2005-11-08; US2005-122030 Applic. Date: 2005-05-05; US2004-961037 Applic. Date: 2004-10-12; US2005-058371 Applic. Date: 2005-02-16; US2002-224743 Applic. Date: 2002-08-22

Inventor: OMOIGUI OSEMWOTA S [US]


Application No.: US20060275509A1  Published: 07/Dec/2006

Title: Rapidly absorbing lipophilic skin compositions and uses therefor

Applicant/Assignee:

Application No.: 10/548851   Filing Date: 04/Mar/2004

Abstract:Topical compositions, and particularly hydrophobic compositions include an essential oil in an amount effective to achieve substantially complete absorption of the composition in the skin without leaving a greasy residue. Especially preferred topical compositions may also include pharmaceutically active agents (e.g., polyphenol), additional essential oils, stabilizers, etc. In further preferred aspects, contemplated compositions may delay onset, or even prevent viral eruptions on the skin, and where applied as a lipstick, will increase reddening of the lip as well as reduce chapping.

Priority: US20030454287P Applic. Date: 2003-03-12; WO2004US06929 Applic. Date: 2004-03-04

Inventor: WEGENER PAUL T [US]


Application No.: US20060275752A1  Published: 07/Dec/2006

Title: Multiparameteric method for assessing immune system status

Applicant/Assignee: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Application No.: 11/447213   Filing Date: 05/Jun/2006

Abstract:The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

Priority: US20050687403P Applic. Date: 2005-06-03

Inventor: SINDHI RAKESH [US]


Application No.: US20060278586A1  Published: 14/Dec/2006

Title: Highly concentrated, biocidally active compositions and aqueous mixtures and methods of making the same

Applicant/Assignee:

Application No.: 11/439571   Filing Date: 23/May/2006

Abstract:The present invention relates to liquid mixtures and compositions having high bromine concentrations that find use as biocides and processes for preparing them.

Priority: US20050753284P Applic. Date: 2005-12-21; US20050689737P Applic. Date: 2005-06-10

Inventor: NALEPA CHRISTOPHER J [US]; AZARNIA FARAH D [US]


Application No.: US20060280705A1  Published: 14/Dec/2006

Title: Cosmetic preparation

Applicant/Assignee:

Application No.: 10/552273   Filing Date: 21/Aug/2006

Abstract:A cosmetic preparation which comprises microparticles distributed in an adhesive solution wherein the microparticles contain a substance affording an esthetic effect.

Priority: EP20040007812 Applic. Date: 2004-03-31; DE200410027282 Applic. Date: 2004-06-04; WO2005EP03330 Applic. Date: 2005-03-30

Inventor: BRUECHERT WERNER [DE]; HUNSINGER URSULA [DE]; WEISS WILLY [DE]


Application No.: US20060280715A1  Published: 14/Dec/2006

Title: Retinoid solutions and formulations made therefrom

Applicant/Assignee:

Application No.: 11/481435   Filing Date: 06/Jul/2006

Abstract:Compositions for topical application for treating a skin disorder (e.g., acne) include a retinoid, which is solubilized completely in alcohol only with the aid of cosolvents such as esters (e.g., alkyl benzoate, isopropyl palmitate, isopropyl myristate, diisopropyl adipate and their derivatives). This completely solubilized retinoid can be used to formulate an emulsion system or liquid to powder suspension containing a second active, such as an antibiotic (e.g., clindamycin).

Priority: US2004-984630 Applic. Date: 2004-11-09; US20040569809P Applic. Date: 2004-05-11

Inventor: VISHNUPAD MOHAN [US]; VISHNUPAD NAOMI [US]


Application No.: US20060280783A1  Published: 14/Dec/2006

Title: Method and composition for transdermal drug delivery

Applicant/Assignee: ACRUX DDS PTY LTD

Application No.: 11/445463   Filing Date: 02/Jun/2006

Abstract:The invention is directed to a transdermal drug delivery composition which includes at least one physiologically active agent

and at least one volatile solvent

and at least one viscosity modulating agent. The invention extends to methods of administering such a composition to a subject and treatment of subjects using the composition.

Priority: AU20050902902 Applic. Date: 2005-06-03; US20050752884P Applic. Date: 2005-12-23

Inventor: DIPIETRO TONY [AU]; HUMBERSTONE ANDREW [AU]; GONDA IGOR [AU]; WATKINSON ADAM [AU]; ROBINSON MONIQUE [AU]; SETIAWAN KERRIE [AU]; STONE CAROLYN [AU]; WILKINS NINA [AU]


Application No.: US20060280810A1  Published: 14/Dec/2006

Title: Disinfecting teat care compositions

Applicant/Assignee:

Application No.: 10/575326   Filing Date: 12/Jun/2006

Abstract:The present invention relates to novel compositions which are used to produce nitrous acid, in preferred aspects such compositions comprise a protic acid and a metal nitrite, and to methods for using these compositions, in particular for disinfecting mammalian teat skin.

Priority: US2004-780435 Applic. Date: 2004-02-17; US20030511916P Applic. Date: 2003-10-17; WO2004US34142 Applic. Date: 2004-10-15

Inventor: KROSS ROBERT D [US]; GREEN LORRENCE H [US]


Application No.: US20060281146A1  Published: 14/Dec/2006

Title: Novel compositions and methods for the treatment of immune related diseases

Applicant/Assignee: GENETECH, INC

Application No.: 10/527469   Filing Date: 10/Sep/2003

Abstract:The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US20020410174P Applic. Date: 2002-09-11; WO2003US28361 Applic. Date: 2003-09-10

Inventor: BODARY SARAH C [US]; CLARK HILARY [US]; HUNTE BRISDELL [US]; JACKMAN JANET K [US]; SCHOENFELD JILL R [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]; WU THOMAS D [US]


Application No.: US20060281710A1  Published: 14/Dec/2006

Title: 17SS-HSD1 and STS inhibitors

Applicant/Assignee: SOLVAY PHARMACEUTICALS GMBH

Application No.: 11/441200   Filing Date: 26/May/2006

Abstract:The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment, inhibition, prophylaxis or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17beta-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17beta-estradiol concentration.

Priority: US20050684540P Applic. Date: 2005-05-26

Inventor: MESSINGER JOSEF [DE]; THOLE HEINRICH-HUBERT [DE]; HUSEN BETTINA [DE]; WESKE MICHAEL [DE]; KOSKIMIES PASI [FI]; PIRKKALA LILA [FI]


Application No.: US20060281761A1  Published: 14/Dec/2006

Title: 4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 11/504325   Filing Date: 14/Aug/2006

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia,

Alzheimer's disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US2004-512800 Applic. Date: 2004-10-27; WO2003US13120 Applic. Date: 2003-04-25; US20020376779P Applic. Date: 2002-04-30

Inventor: WANG JIABING [US]; MCVEAN CAROL A [US]


Application No.: US20060281790A1  Published: 14/Dec/2006

Title: Combination

Applicant/Assignee: NOVARTIS AG

Application No.: 11/508353   Filing Date: 23/Aug/2006

Abstract:The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof

(ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof

and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

Priority: US2005-295928 Applic. Date: 2005-12-07; US2003-362340 Applic. Date: 2003-06-16; WO2001EP09587 Applic. Date: 2001-08-20; US20000327553P Applic. Date: 2000-08-22

Inventor: ALLISON MALCOLM [CH]; GATLIN MARJORIE R [US]


Application No.: US20060282966A1  Published: 21/Dec/2006

Title: Cleansing pad

Applicant/Assignee:

Application No.: 10/562311   Filing Date: 22/Dec/2005

Abstract:A cleansing pad ( 10 ) is made of a web of fibers, forming a substrate ( 11 ), where the substrate ( 11 ) includes a cleansing agent ( 12 ) therein. The cleansing agent ( 12 ) is a pourable soap. In making the cleansing pad ( 10 ), the cleansing agent ( 12 ) is initially heated from solid form into molten/liquid form, and distributed essentially throughout one or more portions of the substrate ( 11 ) in molten form to coat the fibers in said portions of the substrate ( 11 ). After application of the molten cleansing agent ( 12 ), the substrate ( 11 ) is then allowed to cool such that the molten cleansing agent ( 12 ) solidifies and remains solid at a desired range at and above room temperature, forming the cleansing pad ( 10 ). Thereafter, in use, the cleansing pad ( 10 ) is applied for cleaning an object in conjunction with a solvent such as water. The solvent dissolves the solidified cleansing agent ( 12 ). The cleansing pad ( 10 ) can be used in this manner multiple times without the need for application of additional cleansing agent ( 12 ) to the cleansing pad ( 10 ). As such, the cleansing pad ( 10 ) is a self-contained, long lasting product that maintains its creamy lather during multiple uses and does not require the user to reapply cleansing agents to the cleansing pad ( 10 ) with every use.

Priority: US2003-696069 Applic. Date: 2003-10-28; US20030484786P Applic. Date: 2003-07-03; WO2004US21435 Applic. Date: 2004-07-02

Inventor: POPOVSKY MICHAEL [US]; POPOVSKY YELENA [US]; FOOTE SUSANNE [US]; LASSEN SHAWNA [US]; JUNGERMANN ERIC [US]; POPER MAXWELL [US]; MARCUS RAULEE [US]


Application No.: US20060286049A1  Published: 21/Dec/2006

Title: Cosmetic composition comprising a tribochromic compound, process using this composition and uses

Applicant/Assignee:

Application No.: 11/362757   Filing Date: 28/Feb/2006

Abstract:The present disclosure relates to a cosmetic composition comprising, in an appropriate cosmetic medium, at least one tribochromic compound. The present disclosure also relates to a process for making up the lips, skin, or integuments using the compostions disclosed herein, wherein the at least one tribochromatic compound has the property of changing coloration or shade when, once deposited onto the integuments, the lips or the skin, it undergoes a conformational change subsequent to a mechanical stress.

Priority: FR20050002004 Applic. Date: 2005-02-28; US20050694432P Applic. Date: 2005-06-28

Inventor: GRETHEN-POURILLE CHRYSTEL [FR]; GOURLAOUEN LUC [FR]


Application No.: US20060286054A1  Published: 21/Dec/2006

Title: PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PSORIASIS

Applicant/Assignee: APOLLO PHARMACEUTICAL, INC

Application No.: 11/420642   Filing Date: 26/May/2006

Abstract:Pharmaceutical compositions for the treatment of skin disorders such as psoriasis, acne and eczema, methods of making the compositions and methods of use thereof are described herein. The composition comprises psorberine, an alcohol-water extract isolated from the Mahonia aquifolium plant, and one or more additional active agents. In a preferred embodiment, the one or more active agents is a vitamin D 3 analog, such as calcipotriol. The compositions may also contain excipients such as emollients, surfactants, emulsifiers and buffers. The compositions are formulated into a cream, lotion or ointment for topical administration.

Priority: US20050690990P Applic. Date: 2005-06-15

Inventor: GOMEZ HECTOR J [US]


Application No.: US20060286159A1  Published: 21/Dec/2006

Title: Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect

Applicant/Assignee:

Application No.: 11/446571   Filing Date: 01/Jun/2006

Abstract:The present invention provides methods for treating tendinopathy providing a durability of effect by administering nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. The use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr

Priority: US2004-967707 Applic. Date: 2004-10-15; US20030512070P Applic. Date: 2003-10-17

Inventor: CALVERT MURRELL GEORGE A [AU]; ANG ROBERT [US]; JACOBSON SVEN [US]; GELIEBTER DAVID [US]


Application No.: US20060286184A1  Published: 21/Dec/2006

Title: Composition containing as the active ingredient componantes from salvia sclarea seed

Applicant/Assignee:

Application No.: 10/570810   Filing Date: 25/Aug/2006

Abstract:The present invention concerns a food supplement comprising Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds as well as finished food products comprising the food supplement. The present invention further concerns a nutraceutical or cosmetic preparation comprising as an active ingredient Salvia sclarea seeds, or flour, oil or pulp or extracts obtained from the seeds.

Priority: IL20030157785 Applic. Date: 2003-09-07; WO2004IL00804 Applic. Date: 2004-09-07

Inventor: NATIV DUDAI [IL]; YANIV-BACHARACH ZOHARA [IL]; PUTIEVSKY ELI [IL]; SA ADY DIAH [IL]; SCHAFFERMAN DAN [IL]; CHAIMOVITSH DAVID [IL]


Application No.: US20060287326A1  Published: 21/Dec/2006

Title: 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK SHARP & DOHME CORP

Application No.: 10/557229   Filing Date: 17/Nov/2005

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair,

HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030483784P Applic. Date: 2003-06-30; WO2004US20548 Applic. Date: 2004-06-25

Inventor: DANKULICH WILLIAM P [US]; KAUFMAN MILDRED L [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20060287327A1  Published: 21/Dec/2006

Title: Helix 12 directed non-steroidal antiandrogens

Applicant/Assignee: ENDORECHERCHE, INC

Application No.: 11/452545   Filing Date: 14/Jun/2006

Abstract:Compounds having the structure (or their salts): are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

Priority: US20050691391P Applic. Date: 2005-06-17

Inventor: LABRIE FERNAND [CA]; BRETON ROCK [CA]; SINGH SHANKAR M [CA]; MALTAIS RENE [CA]


Application No.: US20060287348A1  Published: 21/Dec/2006

Title: 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/557211   Filing Date: 17/Nov/2005

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair,

HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030483680P Applic. Date: 2003-06-30; WO2004US20508 Applic. Date: 2004-06-25

Inventor: DANKULICH WILLIAM P [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20060287349A1  Published: 21/Dec/2006

Title: 17-HETEROCYCLIC-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/569303   Filing Date: 23/Feb/2006

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies,

cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030501664P Applic. Date: 2003-09-10; WO2004US28641 Applic. Date: 2004-09-02

Inventor: MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20060292080A1  Published: 28/Dec/2006

Title: VITAMIN FORMULATION

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/420700   Filing Date: 26/May/2006

Abstract:A pharmaceutical aerosol foam composition, comprising: an effective amount of a pharmaceutically active ingredient, wherein said pharmaceutically active ingredient is a vitamin or analogue thereof

an occlusive agent

an aqueous solvent

an organic cosolvent

wherein the pharmaceutically active ingredient is insoluble in both water and the occlusive agent

and the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use. In a second embodiment, an oil-in water emulsion having a vitamin, an occlusive agent

an aqueous solvent

and an organic cosolvent, wherein the occlusive agent is present in an amount sufficient to form an occlusive layer on the skin.

Priority: AU1998PP05831 Applic. Date: 1998-09-11; US2005-303298 Applic. Date: 2005-12-16; US2004-766202 Applic. Date: 2004-01-27; US2001-719662 Applic. Date: 2001-01-30; WO1999AU00735 Applic. Date: 1999-09-08; US20050686752P Applic. Date: 2005-06-01

Inventor: ABRAM ALBY [AU]; BUCHTA RICHARD [AU]; HOULDEN ROBERT J [AU]; YE ROSE [AU]


Application No.: US20060292085A1  Published: 28/Dec/2006

Title: Medicaments

Applicant/Assignee: INNOVATA BIOMED LIMITED

Application No.: 11/511730   Filing Date: 29/Aug/2006

Abstract:There is described a bimodal pharmaceutical composition comprising effective amounts of a first active ingredient which substantially comprises a coarse fraction and a second active ingredient which substantially comprise a fine fraction characterized in that the coarse fraction possesses a greater mass median aerodynamic diameter than the fine fraction. There is also described a method of delivering a therapeutically effective amount of a substantially fine active ingredient to the lung of a patient by co-administration with a substantially coarse active ingredient.

Priority: GB20010002902 Applic. Date: 2001-02-06; GB20010009215 Applic. Date: 2001-04-12; US2003-467153 Applic. Date: 2003-12-08; WO2002GB00480 Applic. Date: 2002-02-05

Inventor: SANDERS MARK [GB]


Application No.: US20060292094A1  Published: 28/Dec/2006

Title: Composition and method of protection against UV irradiation

Applicant/Assignee:

Application No.: 11/165686   Filing Date: 24/Jun/2005

Abstract:The present invention relates to a composition for use in a nutritional product, dietary supplement, or pharmaceutical compound wherein such composition is used to protect the skin against the effects of ultraviolet (UV) irradiation from the sun or other sources, including but not limited to sunburn, skin redness, swelling, immune suppression, photo-aging, photodamage, and skin cancer. The invention relates to a composition containing a variety of antioxidants, vitamins, and herbal ingredients. The present invention further relates to a method of administering a therapeutically effective amount of the composition ingredients to protect the skin against the effects of UV irradiation.

Priority:

Inventor: BELL ROBERT [US]


Application No.: US20060292185A1  Published: 28/Dec/2006

Title: Topical skin preparations for treatment of skin aging comprising a testosterone ester

Applicant/Assignee:

Application No.: 10/568275   Filing Date: 04/May/2006

Abstract:The present invention concerns Topical skin preparations for the use in the prevention of atrophy and aging of the skin, comprising a testosterone ester with an esterifying acid having between six to eleven carbon atoms.

Priority: IL20030157535 Applic. Date: 2003-08-21; WO2004IL00747 Applic. Date: 2004-08-16

Inventor: DIKSTEIN SHABTAY [IL]


Application No.: US20060292193A1  Published: 28/Dec/2006

Title: ENCAPSULATED COSMETIC COMPOSITION

Applicant/Assignee: ELC MANAGEMENT, LLC

Application No.: 11/425446   Filing Date: 21/Jun/2006

Abstract:The present invention relates to encapsulated cosmetic compositions that are topically applied. The compositions contain at least one frangible capsule that has a seamless shell of a thermo-softening material. The shell is solid at about room temperature and melts upon application to the skin. The shell holds a core cosmetic that is added to a clear gel base. Thus, the color of the capsule is visible and multiple colored capsules can be added to the base for a custom colored composition.

Priority: US20050694312P Applic. Date: 2005-06-27

Inventor: LEE WILSON A [US]; SILVEIRA LEIGH A [US]


Application No.: US20060292223A1  Published: 28/Dec/2006

Title: Gel compositions for topical administration

Applicant/Assignee: WARNER CHILCOTT COMPANY INC,

Application No.: 11/454717   Filing Date: 16/Jun/2006

Abstract:Pharmaceutical gel compositions containing pharmacologically active agent for topical administration, as well as a method of making the same, are disclosed.

Priority: US20050691441P Applic. Date: 2005-06-16

Inventor: WOOLFSON DAVID [IE]; MC ILROY JIM [IE]


Application No.: US20060292224A1  Published: 28/Dec/2006

Title: Pharmaceutical composition

Applicant/Assignee:

Application No.: 10/541786   Filing Date: 09/Jan/2004

Abstract:This invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule. The invention also relates to methods of forming particles comprising a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule.

Priority: GB20030000427 Applic. Date: 2003-01-09; WO2004GB00044 Applic. Date: 2004-01-09

Inventor: MOORE BARRY D [GB]; PARKER MARIE C [GB]; PARTRIDGE JOHANN [GB]; VOS JAN [GB]; KREINER MICHAELA M [GB]; STEVEN HOWARD N E [GB]; FLORES MARIA V [GB]; ROSS ALISTAIR [GB]


Application No.: US20060292253A1  Published: 28/Dec/2006

Title: Active substance combination of licochalcone A and phenoxyethanol

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/514214   Filing Date: 01/Sep/2006

Abstract:A cosmetic or pharmaceutical preparation comprising licochalcone A and phenoxyethanol. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: DE20031056164 Applic. Date: 2003-12-02; US2004-001224 Applic. Date: 2004-12-02

Inventor: KRUSE INGE [DE]; RASCHKE THOMAS [DE]; VIETZKE JENS-PETER [DE]; ECKERT JULIA [DE]


Application No.: US20060293362A1  Published: 28/Dec/2006

Title: Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them

Applicant/Assignee:

Application No.: 11/473224   Filing Date: 22/Jun/2006

Abstract:The invention relates to nitro-substituted 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).

Priority: US20050694326P Applic. Date: 2005-06-27

Inventor: NORBERT HOFGEN [DE]; HILDEGARD KUSS [DE]; KARIN STEINIKE [DE]; HANS-JOACHIM JANSCH [DE]; RAMONA DIECKMANN [DE]; HELGE HARTENHAUER [DE]; CHRIS RUNDFELDT [DE]; JOACHIM HOPPMANN [DE]; CHRISTIN GALETZKA [DE]; ANTJE GASPARIC [DE]; REGINA DRAHEIM [CH]


Application No.: US20060293431A1  Published: 28/Dec/2006

Title: Cosmetic composition comprising silicone particles

Applicant/Assignee:

Application No.: 11/449799   Filing Date: 09/Jun/2006

Abstract:Disclosed herein is a composition comprising concave particles of a silicone material and a fatty phase comprising at least one oil and at least one non-spherical silicone elastomer. The composition may make it possible to obtain a make-up for the skin and/or lips which is non-drying and/or which does not exhibit tightness and/or which is comfortable.

Priority: FR20050051553 Applic. Date: 2005-06-09; US20050690500P Applic. Date: 2005-06-15

Inventor: KANI TOSHIYUKI [JP]; DUMOUSSEAUX CHRISTOPHE [JP]


Application No.: US20070003487A1  Published: 04/Jan/2007

Title: Composition, method and pharmaceutical preparation for pharmaceutical spray suspensions

Applicant/Assignee:

Application No.: 10/553389   Filing Date: 16/Apr/2004

Abstract:A pharmaceutical composition, constituting a spray suspension includes at least one liquid excipient and at least one solid excipient substantially insoluble in the liquid excipient, and at least one pharmaceutical active ingredient. A method of preparing porous suspension particles includes: a) wet-milling or dry-milling the solid excipient(s) or a mixture of at least one active ingredient and a solid excipient(s) in a milling equipment inducing essentially compression and shear forces, resulting in fine particulate quality, where more than 90% by weight is smaller than 5 m

b) drying and aggregating the product of step a) alone or with the addition of at least one active ingredient, in fine particulate form, which will produce essentially isodiametrical aggregate particles. A suspension particles obtainable by the method pharmaceutical preparation, utilising the composition or porous suspension particles and a method for treatment of disorders using the preparation are disclosed.

Priority: US20030463326P Applic. Date: 2003-04-17; WO2004SE00591 Applic. Date: 2004-04-16

Inventor: EK RAGNAR [SE]


Application No.: US20070003496A1  Published: 04/Jan/2007

Title: Sunless tanning composition and method of sunless tanning

Applicant/Assignee: PLAYTEX PRODUCTS, INC

Application No.: 11/174044   Filing Date: 01/Jul/2005

Abstract:A sunless tanning composition having dihydroacetone and an amphoglycinate (amphoacetate) in an amount effective for sunless tanning is provided. Also provided is a method of sunless tanning having the step of topically applying to the skin an effective amount of a sunless tanning composition having dihydroacetone and an amphoglycinate.

Priority:

Inventor: DUEVA-KOGANOV OLGA [US]; RUSSO THOMAS [US]; SANOGUEIRA JAMES P [US]


Application No.: US20070003504A1  Published: 04/Jan/2007

Title: Method of enhanced benzoyl peroxide application

Applicant/Assignee:

Application No.: 11/476959   Filing Date: 28/Jun/2006

Abstract:Methods of treating acne are disclosed comprising applying a benzoyl peroxide solution in one or more solvents to the skin of a user and applying a sealer thereto. The methods are useful to improve the penetration of active drug into the skin in need thereof, and are highly effective in treating P. Acne.

Priority: US20050695033P Applic. Date: 2005-06-29

Inventor: RAMIREZ JOSE E [US]; FARYNIARZ JOSEPH R [US]


Application No.: US20070003510A1  Published: 04/Jan/2007

Title: Preparations containing an extract of eperua falcata and/or constituents of the latter

Applicant/Assignee:

Application No.: 10/547031   Filing Date: 25/May/2006

Abstract:A cosmetic, pharmaceutical or dermatological preparation containing extract of the plant Eperua falcata, active principles of the plant Eperua falcata, astilbin or engeletin. The preparation is useful to inhibit release of pro-imflammatory mediators and neuropeptides, including CGRP and SP, for skin and hair treatment, including, sensitive skin, acne, scalp itch and neurogenous inflammation.

Priority: EP20030290483 Applic. Date: 2003-02-28; WO2003EP14598 Applic. Date: 2003-12-19

Inventor: HENRY FLORENCE [FR]; MOSER PHILIPPE [FR]; DANOUX LOUIS [FR]; CONTET-AUDONNEAU JEAN-LUC [FR]; PAULY GILLES [FR]


Application No.: US20070003540A1  Published: 04/Jan/2007

Title: Stem cells having increased sensitivity to sdf-1 and methods of generating and using same

Applicant/Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 10/552299   Filing Date: 07/Apr/2004

Abstract:The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

Priority: IL20030155302 Applic. Date: 2003-04-08; IL20030159306 Applic. Date: 2003-12-10; WO2004IL00314 Applic. Date: 2004-04-07

Inventor: KOLLET ORIT [IL]; LAPIDOT TSVEE [IL]


Application No.: US20070003639A1  Published: 04/Jan/2007

Title: Preparation for oral administration containing physiologically active fatty acids and oligomer proanthocyanidin

Applicant/Assignee:

Application No.: 10/553374   Filing Date: 03/Apr/2004

Abstract:Compositions for oral administration of (a) a physiologically active fatty acid containing about 16 to 26 carbon atoms and about 2 to 6 double bonds, and esters or glycerides thereof

and (b) an oligomeric proanthocyanidin or a plant extract containing said proanthocyanidin are disclosed. Methods of using the compositions as additives in food products are also disclosed.

Priority: DE20031017109 Applic. Date: 2003-04-14; WO2004EP03558 Applic. Date: 2004-04-03

Inventor: LE HEN FERRENBACH CATHERINE [FR]; FABRY BERND [DE]; RULL PROUS SANTIAGO [ES]; CARITE CHRISTOPHE [FR]; BUCHWALD-WERNER SYBILLE [DE]


Application No.: US20070004011A1  Published: 04/Jan/2007

Title: Extracts obtained from cell line cultures from plants belonging to the Oleaceae family (e.g. Syringa vulgaris), their preparation and use

Applicant/Assignee: I.R.B. ISTITUTO DI RICERCHE BIOTECNOLOGICHE S.R.I I.R.B. ISTITUTO DI RICERCHE BIOTECNOLOGICHE S.R.L

Application No.: 11/455501   Filing Date: 19/Jun/2006

Abstract:The present invention refers to the use of extracts from selected and stabilised cell lines comprising phenylpropanoids with high anti-oxidant capacity having a verbascoside titre of between 20% and 90% and a chromophore-free fraction of between 80% and 10%, in human and veterinary medicine, and for nutritional and cosmetic purposes.

Priority: EP20050425442 Applic. Date: 2005-06-20; EP20050425586 Applic. Date: 2005-08-08

Inventor: DAL MONTE RENZO [IT]; DAL TOSO ROBERTO [IT]; MINGHETTI ANACLETO [IT]; CRESPI PERELLINO NICOLETTA [IT]; PRESSI GIOVANNA [IT]


Application No.: US20070004689A1  Published: 04/Jan/2007

Title: Antiangiogenic agents

Applicant/Assignee:

Application No.: 11/489263   Filing Date: 19/Jul/2006

Abstract:Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from -OCH3, -OCH2CH3 or -CCCH3

and Z is selected from >C(H)-OH, >C(H)-O-alkyl, >C(H)-O-sulfamate, or >C(H)-dioxolane, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.

Priority: US2005-077977 Applic. Date: 2005-03-11; US20040562793P Applic. Date: 2004-04-16; US20040552692P Applic. Date: 2004-03-12

Inventor: AGOSTON GREGORY E [US]; SHAH JAMSHED H [US]; SUWANDI LITA [US]; LAVALLEE THERESA M [US]; TRESTON ANTHONY M [US]


Application No.: US20070004775A1  Published: 04/Jan/2007

Title: 2,6-Quinolinyl derivatives, processes for preparing them and their uses

Applicant/Assignee: UCB S.A

Application No.: 11/450694   Filing Date: 09/Jun/2006

Abstract:The present invention concerns 2,6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Priority: GB20060000213 Applic. Date: 2006-01-06; GB20050011781 Applic. Date: 2005-06-09; US2005-206158 Applic. Date: 2005-08-18

Inventor: PERRY BENJAMIN [GB]


Application No.: US20070004896A1  Published: 04/Jan/2007

Title: Active energy radiation hardenable skin plaster composition and skin plaster

Applicant/Assignee: TAOGOSEI CO., LTD

Application No.: 10/569461   Filing Date: 24/Feb/2006

Abstract:[Problems] A composition curable with active energy beams for use in skin patches is provided, which is liquid at ordinary temperature, has a practical crosslinking property or curability in the absence of photopolymerization initiators even when irradiated with visible or ultraviolet light, and provides cured films that are not discolored and excellent in various pressure-sensitive adhesive performances and have appropriate pressure-sensitive adhesiveness so as not to cause pain or damage to the horny layer in the patch-applied area even when patches are repeatedly applied and peeled off, as well as excellent water resistance. [Means for solving problems] The composition curable with active energy beams for use in skin patches is liquid at ordinary temperature and comprises (A) a compound having two or more maleimide groups and (B) an oil component, or water or a water-soluble compound.

Priority: JP20030303746 Applic. Date: 2003-08-27; WO2004JP12358 Applic. Date: 2004-08-27

Inventor: ITO KENJI [JP]; KAMIYA DAISUKE [JP]


Application No.: US20070009453A1  Published: 11/Jan/2007

Title: Photoprotective compositions comprising an aqueous phase and a low melting point apolar wax

Applicant/Assignee: L'OREAL

Application No.: 11/482761   Filing Date: 10/Jul/2006

Abstract:Photoprotective cosmetic compositions having at least reduced shine, stickiness, whitening and/or fluffiness and/or enhanced SPF contain an effective amount of at least one UV radiation filtering agent, at least one aqueous phase and at least one apolar wax having a melting point greater than or equal to 30 DEG C. and a fusion enthalpy of less than 250 J/g, formulated into a topically applicable, cosmetically acceptable carrier therefor.

Priority: FR20050052137 Applic. Date: 2005-07-11; US20050702317P Applic. Date: 2005-07-26

Inventor: WILLEMIN CLAUDE [FR]; DUFFET VANESSA [FR]


Application No.: US20070009456A1  Published: 11/Jan/2007

Title: Pigmented anhydrous cosmetic compostition

Applicant/Assignee:

Application No.: 11/473198   Filing Date: 23/Jun/2006

Abstract:The disclosure relates to an anhydrous cosmetic makeup composition comprising at least one volatile oil, at least one pigment in an amount greater than or equal to 25% by weight of pigments, and at least one oil-thickening agent, the composition having a hardness ranging from 0.04 to 0.5 newtons. The disclosure also relates to a makeup kit comprising two compositions, for example anhydrous compositions, of different color. The disclosure also relates to a method of effacing and/or covering skin color inhomogeneties, such as marks, by applying the anhydrous composition, or of a mixture of two compositions of the makeup kit to the skin.

Priority: FR20050051727 Applic. Date: 2005-06-23; US20050696513P Applic. Date: 2005-07-06

Inventor: DELACOUR MARIE-LAURE [FR]; BERRY FLORENCE [FR]


Application No.: US20070009463A1  Published: 11/Jan/2007

Title: Rheology profile for a personal care composition

Applicant/Assignee:

Application No.: 11/480151   Filing Date: 30/Jun/2006

Abstract:Personal care compositions comprising a desirable rheology profile. A method of delivering benefits to hair or skin is provided.

Priority: US20050696926P Applic. Date: 2005-07-06

Inventor: NIEBAUER MICHAEL F [US]; ROYCE DOUGLAS A [US]; HUTCHINS THOMAS A [US]


Application No.: US20070009474A1  Published: 11/Jan/2007

Title: Personal care compositions and methods for the beautification of mammalian skin and hair

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/482314   Filing Date: 07/Jul/2006

Abstract:Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine

2-amino-6-methyl-mercaptopurine

1-methyl xanthine

2-aminopurine

theophylline

theobromine

adenine

adenosine

kinetin

p-chlorophenoxyacetic acid

2,4-dichlorophenoxyacetic acid

indole-3-butyric acid

indole-3-acetic acid methyl ester

beta-naphthoxyacetic acid

2,3,5-triiodobenzoic acid

adenine hemisulfate

n-benzyl-9-(2-tetrahydropyranyl)adenine

1,3-diphenylurea

1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea

zeatin

indole-3-acetic acid

6-benzylaminopurine

alpha-napthaleneacetic acid

6-2-furoylaminopurine

green tea extract

white tea extract

menthol

tea tree oil

ginsenoside-RB1

ginsenoside-RB3

ginsenoside-RC

ginsenoside-RD

ginsenoside-RE

ginsenoside-RG1

ginseng root extract

ginseng flower extract

pomegranate extract, extracts from Ajuga turkestanica

extracts from viola tricolor and combinations thereof

an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

Priority: US20050697819P Applic. Date: 2005-07-08

Inventor: XIE SANCAI [US]; SREEKRISHNA KOTIKANYADANAM [US]; NEWLAND ABBY B [US]; BASCOM CHARLES C [US]; KACZVINSKY JOSEPH R JR [US]; LAMMERS KEREN M [US]; VANOOSTHUYZE KRISTINA EMMA I [GB]


Application No.: US20070009525A1  Published: 11/Jan/2007

Title: Human Endokine Alpha and Methods of Use

Applicant/Assignee: HUMAN GENOME SCIENCES, INC

Application No.: 11/427956   Filing Date: 30/Jun/2006

Abstract:The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

Priority: US2002-136511 Applic. Date: 2002-05-02; US2000-513584 Applic. Date: 2000-02-25; US1999-345790 Applic. Date: 1999-07-01; US1997-912227 Applic. Date: 1997-08-15; US19990136788P Applic. Date: 1999-05-28; US19990122099P Applic. Date: 1999-02-26; US19960024058P Applic. Date: 1996-08-16

Inventor: YU GUO-LIANG [US]; NI JIAN [US]; ROSEN CRAIG A [US]


Application No.: US20070009582A1  Published: 11/Jan/2007

Title: Composition useful as an adhesive and use of such a composition

Applicant/Assignee:

Application No.: 10/574916   Filing Date: 07/Apr/2006

Abstract:A pressure sensitive adhesive composition comprising one or more hydrogel-forming hydrophilic homopolymers or heteropolymers and one or more amphiphilic block-copolymers comprising hydrophobic polymer blocks being incompatible and hydrophilic polymer blocks is useful, for example, in transdermal drug delivery systems and other medical, pharmaceutical and cosmetic products that adhere to the skin or other body surface.

Priority: DK20030004178 Applic. Date: 2003-10-07; WO2004DK00677 Applic. Date: 2004-10-07

Inventor: MADSEN NIELS J [DK]; HOEJ CARSTEN [DK]


Application No.: US20070010443A1  Published: 11/Jan/2007

Title: Monitoring and modulating HGF/HGFR activity

Applicant/Assignee:

Application No.: 11/394422   Filing Date: 31/Mar/2006

Abstract:Provided are methods and compositions for the modulation of hepatocyte growth factor activity to regulate lymphatic vessel development and function. Methods and composition for the monitoring and treatment of skin disorders, lymphedema, and metastatic cancers are disclosed. Also described are methods of identifying inhibitors of hepatocyte growth factor dependent lymphangiogenesis.

Priority: US20050667463P Applic. Date: 2005-03-31

Inventor: DETMAR MICHAEL [CH]; KAJIYA KENTARO [JP]


Application No.: US20070010457A1  Published: 11/Jan/2007

Title: Caspase inhibitors and uses thereof

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 11/522375   Filing Date: 14/Sep/2006

Abstract:The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-("IL-1"), apoptosis-, interferon-y inducing factor-(IGIF), interferon-gamma-("IFN-gamma"), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention.

This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-gamma production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-gamma-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.

Priority: US2002-127324 Applic. Date: 2002-04-19; US20010285051P Applic. Date: 2001-04-19

Inventor: DIU-HERCEND ANITA [FR]; GOLEC JULIAN [GB]; HERCEND THIERRY [FR]; KNEGTEL RONALD [GB]; LANG PAUL [FR]; MILLER ANDREW [GB]; MILLER KAREN [GB]; MORTIMORE MICHAEL [GB]; WEBER PETER [GB]


Application No.: US20070010464A1  Published: 11/Jan/2007

Title: Avermectin and praziquantel combination therapy

Applicant/Assignee: PFIZER, INC

Application No.: 11/520830   Filing Date: 13/Sep/2006

Abstract:An antiparasitic combination therapy compising a combination of a 13-monosaccharide 5-oxime avermectin, such as selamectin, and praziquantel in a veterinarily acceptable carrier, diluent or adjuvant. Also provided is a method of treatment or prophylaxis of a parasitic infestation as well as a kit useful in the treatment or prophylaxis of a parasitic infestation of flea, heartworm or tapeworm in a mammal.

Priority: US2002-116880 Applic. Date: 2002-04-05; US2004-761636 Applic. Date: 2004-01-21; US20010292395P Applic. Date: 2001-05-21

Inventor: BISHOP BERNARD F [GB]


Application No.: US20070010505A1  Published: 11/Jan/2007

Title: Methods of treating disease states using antiangiogenic agents

Applicant/Assignee:

Application No.: 11/519570   Filing Date: 12/Sep/2006

Abstract:Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.

Priority: US2004-856340 Applic. Date: 2004-05-28; US20030474288P Applic. Date: 2003-05-28

Inventor: AGOSTON GREGORY E [US]; LAVALLEE THERESA M [US]; PRIBLUDA VICTOR S [US]; SHAH JAMSHED H [US]; TRESTON ANTHONY M [US]


Application No.: US20070014745A1  Published: 18/Jan/2007

Title: Skin make-up composition comprising a resin

Applicant/Assignee: L'OREAL

Application No.: 11/484625   Filing Date: 12/Jul/2006

Abstract:The present invention relates to a skin make-up or care composition containing a liquid fatty phase having at least one resin having a number-average molecular weight of less than or equal to 10 000 g/mol, chosen from rosin, rosin derivatives, hydrocarbon-based resins, and mixtures thereof. The invention also relates to a non-therapeutic use of the invention composition in a process for making up or caring for the skin and for obtaining a deposit on the skin which has good transfer resistance, in particular in the presence of sebum.

Priority: US20050698884P Applic. Date: 2005-07-13

Inventor: ARNAUD PASCAL [FR]; LU SHAOXIANG [US]


Application No.: US20070014777A1  Published: 18/Jan/2007

Title: Protein compositions for promoting wound healing and skin regeneration

Applicant/Assignee: ESSENTIAL SKINCARE, LLC

Application No.: 11/430574   Filing Date: 09/May/2006

Abstract:Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell suspensions are described. The methods include the steps of administering to an area of wounded or non-wounded skin therapeutically effective amounts of alpha1-antitrypsin, alkaline phosphatase (such as placental alkaline phosphatase), transferrin, and alpha1-acid glycoprotein in compositions that contain at least two of these proteins, or their active derivatives, as the major active components. The compositions can be administered topically and/or by injection, or both.

The invention also provides regimens for restoring or maintaining the strength and thickness of wounded, non-wounded and transplanted skin as well as developing new skin from skin cell suspensions comprising periodically administering one or more compositions topically and/or by injection.

Priority: US20050698321P Applic. Date: 2005-07-12

Inventor: KISS ZOLTAN [US]


Application No.: US20070015262A1  Published: 18/Jan/2007

Title: Extracts from Ajuga reptans cell lines, their preparation and use

Applicant/Assignee: I.R.B. ISTITUTO DI RICERCHE BIOTECNOLOGICHE S.R.L

Application No.: 11/455505   Filing Date: 19/Jun/2006

Abstract:The present invention relates to selected and stabilized cell line extracts from Ajuga reptans comprising phenylpropanoids having high antioxidating capacity with a teupolioside titre of between 20% and 90% and a chromophore-free fraction of between 80% and 10%. Said extracts are for use in human and veterinary therapy and for nutritional and cosmetic purposes. Furthermore, the invention relates to a novel phenylpropanoid molecule denominated isoteupolioside.

Priority: EP20050425441 Applic. Date: 2005-06-20; EP20050425585 Applic. Date: 2005-08-08

Inventor: DAL MONTE RENZO [IT]; DAL TOSO ROBERTO [IT]; MINGHETTI ANACLETO [IT]; CRESPI PERELLINO NICOLETTA [IT]; PRESSI GIOVANNA [IT]


Application No.: US20070015809A1  Published: 18/Jan/2007

Title: HISTONE DEACETYLASE INHIBITORS

Applicant/Assignee: TAKEDA SAN DIEGO, INC

Application No.: 11/457260   Filing Date: 13/Jul/2006

Abstract:Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.

Priority: US20050699139P Applic. Date: 2005-07-14

Inventor: BRESSI JEROME C [US]; GANGLOFF ANTHONY R [US]; KWOK LILY [US]


Application No.: US20070016277A1  Published: 18/Jan/2007

Title: Lip augmentation device

Applicant/Assignee:

Application No.: 11/476591   Filing Date: 29/Jun/2006

Abstract:The present invention is of a method of facilitating lip augmentation, the method comprising treating the lip area with an electricity generating device. The present invention further provides devices and kits for lip augmentation.

Priority: US20050695848P Applic. Date: 2005-07-05

Inventor: KARAT CAROL [IL]; TAL ISRAEL [IL]; MAVOR DANIELA [IL]; JAYES DALIA [IL]


Application No.: US20070020202A1  Published: 25/Jan/2007

Title: Sunless tanning substrate

Applicant/Assignee: PLAYTEX PRODUCTS, INC

Application No.: 11/479566   Filing Date: 30/Jun/2006

Abstract:The present invention provides a sunless tanning substrate having one or more sunless tanning enhancers, which adjust the rate of color development and/or adjust or customize the color developed on the skin. The present invention further provides a method of sunless tanning comprising the step of using the sunless tanning substrate of the present invention either prior to application, simultaneously with application, after application, or any combinations thereof, of one or more sunless tanning actives or agents to the skin. The present invention also provides a sunless tanning kit that includes one or more of the sunless tanning substrates.

Priority: US20050696316P Applic. Date: 2005-07-01

Inventor: SANOGUEIRA JAMES [US]; DUEVA-KOGANOV OLGA V [US]; RUSSO THOMAS [US]


Application No.: US20070020204A1  Published: 25/Jan/2007

Title: Photoprotecting/cosmetic compositions comprising benzotriazole and bis-resorcinyltriazine

Applicant/Assignee: SOCIETE L'OREAL, S.A L'OREAL

Application No.: 11/529618   Filing Date: 29/Sep/2006

Abstract:Topically applicable sunscreen/cosmetic compositions suited for the improved photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise an effective SPF-maintaining and water remanence-enhancing amount of intimate admixture of (a) at least one benzotriazole first sunscreen compound and (b) at least one bis-resorcinyltriazine second sunscreen compound, formulated into (c) a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990001729 Applic. Date: 1999-02-12; US2004-855350 Applic. Date: 2004-05-28; US2001-927488 Applic. Date: 2001-08-13; WO2000FR00257 Applic. Date: 2000-02-03

Inventor: CANDAU DIDIER [FR]


Application No.: US20070020206A1  Published: 25/Jan/2007

Title: Use of biotin or a biotin derivative for lightening skin and treating age spots

Applicant/Assignee:

Application No.: 10/569784   Filing Date: 24/Feb/2006

Abstract:The present invention relates to the use of biotin alone, preferably, however, with vitamin C or a derivative thereof, for the preparation of a cosmetic composition or of a pharmaceutical composition for skin-lightening purposes, for the elimination of skin color irregularities and for the treatment of senile lentigines.

Priority: EP20030018730 Applic. Date: 2003-08-26; WO2004EP09048 Applic. Date: 2004-08-12

Inventor: JERMANN ROLAND [CH]; LUTHER HELMUT [DE]


Application No.: US20070020213A1  Published: 25/Jan/2007

Title: Foamable composition combining a polar solvent and a hydrophobic carrier

Applicant/Assignee: FOAMIX LTD

Application No.: 11/488989   Filing Date: 19/Jul/2006

Abstract:The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent

(2) at least one surface-active agent

(3) water

and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US2004-835505 Applic. Date: 2004-04-28; US2004-922358 Applic. Date: 2004-08-20; US2005-124676 Applic. Date: 2005-05-09; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16; US20030497648P Applic. Date: 2003-08-25; US20020429546P Applic. Date: 2002-11-29; US20050700702P Applic. Date: 2005-07-19

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]


Application No.: US20070020221A1  Published: 25/Jan/2007

Title: Regulation of mammalian keratinous tissue using personal care compositions comprising cetyl pyridinium chloride

Applicant/Assignee:

Application No.: 11/391812   Filing Date: 29/Mar/2006

Abstract:Personal care composition including a first skin and/or hair care active cetyl pyridinium chloride

and at least one additional skin and/or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and/or combinations thereof

and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.

Priority: US20050681626P Applic. Date: 2005-05-17; US20050722384P Applic. Date: 2005-09-30

Inventor: BISSETT DONALD L [US]


Application No.: US20070020304A1  Published: 25/Jan/2007

Title: Non-flammable insecticide composition and uses thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/481596   Filing Date: 06/Jul/2006

Abstract:The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide

at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%

or about 10% to about 20%

or about 20% to about 50% by weight

about 0.1% to about 5% by weight of a surface-active agent

about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent

and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20050696878P Applic. Date: 2005-07-06

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]


Application No.: US20070020735A1  Published: 25/Jan/2007

Title: IL-17 homologous polypeptides and therapeutic uses thereof

Applicant/Assignee: GENENTECH, INC

Application No.: 11/529324   Filing Date: 29/Sep/2006

Abstract:The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Priority: US2003-617573 Applic. Date: 2003-07-11; US2001-000157 Applic. Date: 2001-10-30; US2001-931836 Applic. Date: 2001-08-16; WO2000US05601 Applic. Date: 2000-03-01; US2001-929404 Applic. Date: 2001-08-13; WO2000US05841 Applic. Date: 2000-03-02; US2001-918585 Applic. Date: 2001-07-30; WO2000US04341 Applic. Date: 2000-02-18; US2001-908827 Applic. Date: 2001-07-18; US2000-747259 Applic. Date: 2000-12-20; WO2001US21735 Applic. Date: 2001-07-09; WO2001US21066 Applic. Date: 2001-06-29; WO2001US19692 Applic. Date: 2001-06-20; US2001-874503 Applic. Date: 2001-06-05; WO2001US17800 Applic. Date: 2001-06-01; US2001-854280 Applic. Date: 2001-05-10; US2001-854208 Applic. Date: 2001-05-10; US1999-311832 Applic. Date: 1999-05-14; US2001-816744 Applic. Date: 2001-03-22; WO2001US06520 Applic. Date: 2001-02-28; WO2000US34956 Applic. Date: 2000-12-20; WO2000US32678 Applic. Date: 2000-12-01; WO2000US30873 Applic. Date: 2000-11-10; WO2000US23328 Applic. Date: 2000-08-24; US2000-644848 Applic. Date: 2000-08-22; WO2000US15264 Applic. Date: 2000-06-02; WO2000US07532 Applic. Date: 2000-03-21; WO1999US31274 Applic. Date: 1999-12-30; US1999-380142 Applic. Date: 1999-08-25; WO1999US10733 Applic. Date: 1999-05-14; US1999-380138 Applic. Date: 1999-08-25; WO1999US05028 Applic. Date: 1999-03-08; US20000253646P Applic. Date: 2000-11-28; US20000244072P Applic. Date: 2000-10-26; US20000242837P Applic. Date: 2000-10-24; US20000213807P Applic. Date: 2000-06-22; US20000191007P Applic. Date: 2000-03-21; US20000175481P Applic. Date: 2000-01-11; US19990172096P Applic. Date: 1999-12-23; US19980113621P Applic. Date: 1998-12-23; US19980085579P Applic. Date: 1998-05-15; US19990134287P Applic. Date: 1999-05-14; US19990131022P Applic. Date: 1999-04-26; US19990130232P Applic. Date: 1999-04-21

Inventor: CHEN JIAN [US]; FILVAROFF ELLEN [US]; FONG SHERMAN [US]; FRENCH DOROTHY [US]; GODDARD AUDREY [US]; GODOWSKI PAUL J [US]; GRIMALDI J C [US]; GUMEY AUSTIN L [US]; HILLAN KENNETH J [US]; HYMOWITZ SARAH G [US]; LI HANZHONG [US]; PAN JAMES [CA]; STAROVASNIK MELISSA A [US]; TUMAS DANIEL [US]; LOOKEREN MENNO V [US]; VANDLEN RICHARD [US]; WATANABE COLIN K [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]; YANSURA DANIEL G [US]


Application No.: US20070021326A1  Published: 25/Jan/2007

Title: Composition and its Therapeutic Use

Applicant/Assignee: INSIGNION HOLDINGS LIMITED AND VERITRON LIMITED

Application No.: 11/534914   Filing Date: 25/Sep/2006

Abstract:A composition having a variety of therapeutic and cosmetic uses comprises: (i) a vitamin

(ii) a metal salt that provides metal ions in vivo

and (iii) insulin or a growth hormone. Such a composition is useful for treating, for example, genetic disorders, skin diseases, cancer and viral infections.

Priority: GB20020012405 Applic. Date: 2002-05-29; US2003-447770 Applic. Date: 2003-05-29; US20020407373P Applic. Date: 2002-08-30

Inventor: HAMID MISHAL [US]; YOUNIS RAFEDA M A [AE]; AL SARI KARAM M H [AE]; AL SARI SAAD M H [AE]; AL SARI AHMAD M H [AE]


Application No.: US20070021360A1  Published: 25/Jan/2007

Title: Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase

Applicant/Assignee:

Application No.: 10/475684   Filing Date: 31/Aug/2004

Abstract:A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and/or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.

Priority: US20010286137P Applic. Date: 2001-04-24; WO2002US13135 Applic. Date: 2002-04-23

Inventor: NYCE JONATHAN W [US]; PABALAN JONATHAN [US]; AGUILAR DOUGLAS [US]; MILLER SHOREH [US]; LI YUKUI [US]; SANDRASAGRA ANTHONY [US]; KATZ EVAN [US]; TANG LEI [US]; SHAHABUDDIN SYED [US]


Application No.: US20070021379A1  Published: 25/Jan/2007

Title: Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities

Applicant/Assignee: PHARMENA NORTH AMERICA INC

Application No.: 11/484892   Filing Date: 11/Jul/2006

Abstract:The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.

Priority: US20050698292P Applic. Date: 2005-07-11

Inventor: BENDER ROBERT [CA]; CHLOPICKI STEFAN [PL]; GEBICKI JERZY [PL]


Application No.: US20070021382A1  Published: 25/Jan/2007

Title: Nitric oxide donors and uses thereof

Applicant/Assignee: RENOPHARM LTD

Application No.: 10/555664   Filing Date: 04/Nov/2005

Abstract:Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.

Priority: US20040567824P Applic. Date: 2004-05-05; US20050651619P Applic. Date: 2005-02-11; WO2005IL00481 Applic. Date: 2005-05-05

Inventor: ASSAF PETER [IL]; GAZALEEN-MARIEE ELHAM [IL]; NAVEH MICHAEL [IL]


Application No.: US20070021449A1  Published: 25/Jan/2007

Title: Pyrimidine derivatives for the prevention of hiv infection

Applicant/Assignee:

Application No.: 10/544735   Filing Date: 04/Feb/2004

Abstract:This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a<1>=a<2>-a<3>=a<4>- and -b<1>=b<2>-b<3>=b<4>- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl

and pharmaceutical compositions comprising them.

Priority: WO2003EP01291 Applic. Date: 2003-02-07; WO2004EP01011 Applic. Date: 2004-02-04

Inventor: HEERES JAN [BE]; LEWI PAULUS J [BE]; JANSSEN PAUL A J [BE]; DE JONGE MARC R [NL]; KOYMANS LUCIEN M H [BE]; DAEYAERT FREDERIK F D [BE]; VINKERS HENDRIK M [BE]; GUILLEMONT JEROME E G [FR]; PASQUIER ELISABETH T J [FR]; ARTS FRANK XAVIER J H [BE]


Application No.: US20070021590A1  Published: 25/Jan/2007

Title: Secreted protein family

Applicant/Assignee:

Application No.: 10/547529   Filing Date: 05/Jun/2006

Abstract:This invention relates to a new family of secreted proteins, termed the SECFAMI family, its family members including the novel proteins INSP113, INSP114, INSP115, INSP116 and INSP117, herein identified as secreted proteins containing epidermal growth factor (EGF) fold-containing domains, ranging from 125-153 amino acids in length and containing eight conserved cysteine residues and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Priority: GB20030006771 Applic. Date: 2003-03-24; WO2004GB01248 Applic. Date: 2004-03-24

Inventor: POWER CHRISTINE [FR]; YORKE MELANIE [CH]; FAGAN RICHARD J [GB]; MIACHALOVICH DAVID [GB]; MCKENDRICK IAIN [GB]


Application No.: US20070025930A1  Published: 01/Feb/2007

Title: Dibenzoilmethane derivative compounds, the use thereof in the form of photoactivable solar filters and cosmetic compositions containing said compounds

Applicant/Assignee: UNIVERSITE PAUL SABATIER TOULOUSE 3 LABORATOIRE BIODERMA CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Application No.: 10/564888   Filing Date: 15/Jul/2004

Abstract:The present invention relates to dibenzoylmethane-based compounds of formula 1, and also to salts or solvates thereof, and to the process for preparing them. The invention also relates to the use of a compound of formula (I) as an agent for protecting the skin or the hair against UV radiation and to a cosmetic and/or dermatological product, characterized in that it comprises a compound of formula (I) as active principle.

Priority: FR20030008736 Applic. Date: 2003-07-17; WO2004FR01859 Applic. Date: 2004-07-15

Inventor: RICO-LATTES ISABELLE [FR]; WETZ FABIENNE [FR]; ROUTABOUL CORINNE [FR]; DENIS ALAIN [FR]


Application No.: US20070025938A1  Published: 01/Feb/2007

Title: Depigmentation method and kit

Applicant/Assignee: L'OREAL

Application No.: 11/192481   Filing Date: 29/Jul/2005

Abstract:The present invention relates to a cosmetic kit for depigmenting human skin comprising a multi-unit receptacle containing a first unit containing a microdermabrasion composition

a second unit containing a skin depigmenting composition

a third unit containing ascorbic acid in powder form

a fourth unit containing a skin soothing composition

optionally, a fifth unit containing a maintenance composition, and optionally a sixth unit containing a photoprotective composition. The present invention also relates to a method for treating human skin in need of depigmentation comprising the successive application, to an area of skin, of the compositions contained in the multi-unit receptacle.

Priority:

Inventor: HANSENNE ISABELLE [US]; FARES HANI [US]; CORNELL MARC [US]; FOLTIS SIDNEY P [US]


Application No.: US20070025949A1  Published: 01/Feb/2007

Title: Compositions and kit for alleviating signs of ageing

Applicant/Assignee: L'OREAL

Application No.: 11/192720   Filing Date: 29/Jul/2005

Abstract:A cosmetic kit for treating human skin comprising a multi-unit receptacle containing: (a) a unit containing a microdermabrasion composition having at least one type of skin abrading particle

(b) a unit containing a peeling composition having at least one skin peeling agent

(c) a unit containing an anti-ageing composition having at least one anti-ageing ingredient

(d) a unit containing a skin soothing composition having at least one skin soothing ingredient

(e) optionally, a unit containing a maintenance composition

and (f) optionally, a unit containing a photoprotective composition.

Priority:

Inventor: HANSENNE ISABELLE [US]; FARES HANI [US]; CORNELL MARC [US]; FOLTIS SIDNEY P [US]


Application No.: US20070025962A1  Published: 01/Feb/2007

Title: Interleukin-8 homologous polypeptides and therapeutic uses thereof

Applicant/Assignee:

Application No.: 11/528596   Filing Date: 28/Sep/2006

Abstract:The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

Priority: US2001-015967 Applic. Date: 2001-12-07; US2001-941992 Applic. Date: 2001-08-28; WO2000US08439 Applic. Date: 2000-03-30; WO2001US06520 Applic. Date: 2001-02-28; US2000-709238 Applic. Date: 2000-11-08; WO2000US23328 Applic. Date: 2000-08-24; WO1999US12252 Applic. Date: 1999-06-02; US19980090696P Applic. Date: 1998-06-25

Inventor: EATON DAN L [US]; FRENCH DOROTHY [US]; GRIMALDI J C [US]; HILLAN KENNETH J [US]; PISABARRO MARIA T [DE]; SCHMIDT KERSTIN N [US]; SMITH VICTORIA [US]; TUMAS DANIEL [US]; VANDLEN RICHARD [US]; WATANABE COLIN K [US]; WILLIAMS P M [US]; WOOD WILLIAM I [US]


Application No.: US20070026486A1  Published: 01/Feb/2007

Title: Coumermycin/novobiocin-regulated gene expression system

Applicant/Assignee: ZHAO,HUI-FEN,SHEN, SHI-HSIANG NATIONAL RESEARCH COUNCIL OF CANADA

Application No.: 10/559411   Filing Date: 09/Jun/2004

Abstract:A chimeric transactivator comprises a transcription activation domain, a repressor protein DNA binding domain and the bacterial DNA gyrase B subunit. A target gene is operatively linked to operator DNA sequences recognized by the repressor binding domain. The addition of the antibiotic coumermycin results in a coumermycin-switched dimerization of the transactivator, which then binds to operator DNA sequences and activates transcription of the target gene. The addition of novobiocin switches off expression of the target gene by abolishing coumermycin-induced dimerization of the transactivator.

Priority: US20030477055P Applic. Date: 2003-06-10; WO2004CA00854 Applic. Date: 2004-06-09

Inventor: ZHAO HUI-FEN [CA]; SHEN SHI-HSIANG [CA]


Application No.: US20070027050A1  Published: 01/Feb/2007

Title: Liquid cleansing composition

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER

Application No.: 11/190599   Filing Date: 27/Jul/2005

Abstract:A mild, aqueous, liquid crystalline structured cleansing and moisturizing composition with low levels of surfactants that include monoalkyl sulfosuccinate surfactant(s) and high levels of hydrophillic emollients is provided that provides a low in-use slip, tight skin feel, and a fast, clean-feel rinse in the absence of substantial levels of soap. Substantial amounts of persistent and fine quality lather are produced with the inventive composition even in the presence of high levels of emollients.

Priority:

Inventor: CROTTY BRIAN A [US]; WEISS JOCHEN [US]; GENCARELLI SUZANNE L [US]; LAGATOL SHAUNA M [US]; RESTREPO NICOLAS E [US]; VILLA VIRGILIO B [US]; SLAVTCHEFF CRAIG S [US]


Application No.: US20070027055A1  Published: 01/Feb/2007

Title: High alcohol content gel-like and foaming compositions

Applicant/Assignee: DEB WORLDWIDE HEALTHCARE INC

Application No.: 11/507626   Filing Date: 22/Aug/2006

Abstract:This invention relates to a "high lower alcohol content" (>40% v/v of a C1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000 cps. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition or from 0-2.0% to prepare a gel-like composition of a final viscosity less than 4,000 cps, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water.

The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Priority: US2004-952474 Applic. Date: 2004-09-29; US20030506172P Applic. Date: 2003-09-29; US20040591601P Applic. Date: 2004-07-28

Inventor: KOIVISTO BRUCE M [CA]; FERNANDEZ DE CASTRO MARIA T [CA]


Application No.: US20070027079A1  Published: 01/Feb/2007

Title: GHRP 2 strips

Applicant/Assignee:

Application No.: 11/189962   Filing Date: 27/Jul/2005

Abstract:The products that exist on the market today that produce the same results are with injection. This new product, HGH Strips, is taken orally through strips that are placed on the back of the toungue. HGH Strips is scientifically developed with GHRP-2 (Growth Hormone Releasing Peptide-2), L-Lysine, L-Argenin and L-Valine which amino acids are specifics for increasing the natural production of GH (Growth Hormone) by the anterior pituitary deep inside the brain

also called Somatotropin, it influences in growth of cells, bones, muscles and organs throughout the body. HGH Strips helps to increasing the levels of IGF-1 (Insulin like Growth Factor-1 is a metabolite of human growth hormone) rise

a natural anabolic growth factor molecule. Studies have found that IGF-1 has increased lean body mass, reduced fat, built up bone and muscle tissue, it may even regenerate nerve tissues and boost the immune system.

Priority:

Inventor: LEITMAN LORN [US]; BARNI GUSTAVO [US]


Application No.: US20070027153A1  Published: 01/Feb/2007

Title: Topical skin-protectant and anti-pruritic compositions

Applicant/Assignee:

Application No.: 11/190116   Filing Date: 27/Jul/2005

Abstract:Topical skin protectant compositions, and more particularly anti-pruritic skin protectant compositions, comprising a skin protective ingredient, a therapeutically effective amount of a pharmaceutically active agent comprising an anesthetic agent or derivative thereof, an oleaginous solvent comprising a substance other than the skin protective ingredient, and an aqueous solvent. These skin protectant compositions are capable of temporarily or permanently reducing, inhibiting, treating, ameliorating, or preventing pruritic skin conditions, as well as other related skin conditions. These compositions are further capable of restoring or repairing a skin lipid barrier of a mammal.

Priority:

Inventor: REETH KEVIN M [US]; REYNOLDS JEFFREY S [US]; CLARK KATHLEEN L [US]


Application No.: US20070027184A1  Published: 01/Feb/2007

Title: Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease

Applicant/Assignee: KALYPSYS, INC

Application No.: 11/496784   Filing Date: 27/Jul/2006

Abstract:Disclosed herein are sulfonamide compounds of Formula VII as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Priority: US20050704091P Applic. Date: 2005-07-29; US20060780129P Applic. Date: 2006-03-07

Inventor: MALECHA JAMES W [US]; NOBLE STEWART A [US]; WILEY BRANDON M [US]; HOFFMAN TIMOTHY Z [US]; BONNEFOUS CELINE [US]; SERTIC MICHAEL [US]; WASH PAUL L [US]; SMITH NICHOLAS D [US]; HASSIG CHRISTIAN A [US]; SCRANTON SHAWN A [US]; PAYNE JOSEPH E [US]; HAGER JEFFERY [US]


Application No.: US20070028311A1  Published: 01/Feb/2007

Title: Therapeutic and diagnostic means for papillomas and other diseases involving ped/pea-15

Applicant/Assignee:

Application No.: 10/559627   Filing Date: 06/Dec/2005

Abstract:The present invention discloses diagnostic methods and means, as well as medicaments in diagnosis, prognosis and therapy of diseases where PED/PEA-15 plays an etiopathogenetic role, in particular papilloma and diabetes. Said methods are based on the determination of PED/PEA-15 levels and the medicaments are based on antisense oligonucleotides. A non-human transgenic animal, expressing high PED/PEA-15 levels, is also disclosed, being it useful as a model for the study of said diseases and evaluation of their therapies.

Priority: IT2003RM00283 Applic. Date: 2003-06-06; WO2004IT00325 Applic. Date: 2004-06-03

Inventor: BEGUINOT FRANCESCO [IT]; MIELE CLAUDIA [IT]; FORMISANO PIETRO [IT]


Application No.: US20070028400A1  Published: 08/Feb/2007

Title: Skin and/or hair treatment agent containing tetrasubstituted cyclohexene compounds

Applicant/Assignee:

Application No.: 10/571088   Filing Date: 04/Oct/2006

Abstract:A composition of matter that is suitable for use on skin or hair. The composition comprises one or more compounds of formula wherein R1, R2, R3 and R5 are as defined in the specification, and at least one other component or element.

Priority: DE20031041663 Applic. Date: 2003-09-08; WO2004EP07627 Applic. Date: 2004-07-10

Inventor: WOLBER RAINER [DE]; SCHERNER CATHRIN [US]; TOM DIECK KAREN [US]; VIETZKE JENS-PETER [US]; SCHLENZ KATHRIN [US]


Application No.: US20070031405A1  Published: 08/Feb/2007

Title: Use of A33 antigens and jam-it

Applicant/Assignee:

Application No.: 11/542578   Filing Date: 02/Oct/2006

Abstract:The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.

Priority: US2002-265542 Applic. Date: 2002-10-03; WO2000US04414 Applic. Date: 2000-02-22; WO2000US14042 Applic. Date: 2000-05-22; WO2000US32678 Applic. Date: 2000-12-01; US1999-254465 Applic. Date: 1999-03-05; WO1999US05028 Applic. Date: 1999-03-08; US1999-380138 Applic. Date: 1999-08-25; US1999-380139 Applic. Date: 1999-08-25; WO1998US19330 Applic. Date: 1998-09-16; US2001-953499 Applic. Date: 2001-09-14; WO1998US24855 Applic. Date: 1998-11-20

Inventor: ASHKENAZI AVI [US]; FONG SHERMAN [US]; GODDARD AUDREY [US]; GURNEY AUSTIN L [US]; NAPIER MARY A [US]; TUMAS DANIEL [US]; WOOD WILLIAM I [US]


Application No.: US20070031474A1  Published: 08/Feb/2007

Title: Implantable preparations

Applicant/Assignee: KHORIONYX

Application No.: 11/499723   Filing Date: 07/Aug/2006

Abstract:Implantable preparation comprising a material which can be obtained from globin that has been modified, especially chemically, to be, at least partially, soluble at physiological pH, the material being biocompatible, and biodegradable in the organism. The material may be soluble at physiological pH, or insoluble at that pH. The preparation may be in the form of a solution, suspension, paste, gel, film, sponge, powder or granules, or a solid implant. Application in particular to the healing, protection or filling of external skin wounds, the filling of wrinkles and skin flaws, the filling of tissue, as means for fixing prostheses or biomaterials, or means for preventing adhesion.

Priority: FR20050008392 Applic. Date: 2005-08-05; US20060774607P Applic. Date: 2006-02-21

Inventor: TAYOT JEAN L [FR]


Application No.: US20070031495A1  Published: 08/Feb/2007

Title: Permeant delivery system and methods for use thereof

Applicant/Assignee:

Application No.: 11/455899   Filing Date: 19/Jun/2006

Abstract:Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface

and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

Priority: US20050691898P Applic. Date: 2005-06-17

Inventor: EPPSTEIN JONATHAN [US]; ENSCORE DAVID [US]; TAGLIAFERRI FRANK [US]; TOLIA GAURAV [US]; CHANG SHULUN [US]; SMITH ALAN [US]; PATEL YOGI [US]; MCRAE STUART [US]


Application No.: US20070031522A1  Published: 08/Feb/2007

Title: Enriched aqueous components of emblica officinalis

Applicant/Assignee:

Application No.: 10/571588   Filing Date: 10/Mar/2006

Abstract:In an extraction process comprising extracting a raw extract from Emblica officinalis the improvement comprising conducting the extraction under conditions of time, temperature and atmosphere, to inhibit the formation of black specks and/or oligomeric and/or polymeric tannins and/or oxidation products thereof.

Priority: US2003-660742 Applic. Date: 2003-09-12; WO2004EP09109 Applic. Date: 2004-08-13

Inventor: CHAUDHURI RATAN [US]; PUCCETTI GERMAIN [US]


Application No.: US20070032419A1  Published: 08/Feb/2007

Title: Fusion polypeptides, and use thereof in antivascular tumor therapy

Applicant/Assignee: ONCOSCIENCE AG

Application No.: 10/569076   Filing Date: 23/Aug/2006

Abstract:The present invention relates to fusion polypeptides, comprising at least two peptides. The invention further relates to the use of these fusion proteins in antivascular therapy of neoplastic diseases and to their use I the production of a drug for the treatment of neoplastic diseases.

Priority: DE20031038733 Applic. Date: 2003-08-22; WO2004EP09364 Applic. Date: 2004-08-20

Inventor: BERDEL WOLFGANG E [DE]; MESTERS ROLF M [DE]


Application No.: US20070032461A1  Published: 08/Feb/2007

Title: 1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof

Applicant/Assignee: BIOXELL S.P.A

Application No.: 10/554769   Filing Date: 30/Apr/2004

Abstract:The invention provides 1,3 acylated, 24-keto vitamin D3 compounds of formula I: wherein: X1 and X1 are each independently H2 or -CH2, provided X1 and X1 are not both -CH2

R1 and R2 are each independently, hydroxyl, OC(O)C1-C4 alkyl, OC(O)hydroxyalkyl, OC(O)haloalkyl, provided that R1 and R2 are not both hydroxyl

R3 and R4 are each independently hydrogen, C1-C4 alkyl, hydroxyalkyl, or haloalkyl, or R3 and R4 taken together with C20 form C3-C6 cylcoalkyl

and R5 and R6 are each independently C1-C4 alkyl, hydroxyalkyl, or haloalkyl

and pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds to treat vitamin D3 associated states, and phar,aceutical compositions containing the compounds are also disclosed.

Priority: US20030466641P Applic. Date: 2003-04-30; WO2004US13345 Applic. Date: 2004-04-30

Inventor: ADORINI LUCIANO [IT]; PENNA GIUSEPPE [IT]; USKOKOVIC MILAN R [US]; MAEHR HUBERT [US]


Application No.: US20070032462A1  Published: 08/Feb/2007

Title: Novel methods for the preparation of dhea derivatives

Applicant/Assignee:

Application No.: 10/552336   Filing Date: 06/Apr/2004

Abstract:The invention relates to a method for the production of DHEA derivatives, such as 7-oxo-DHEA and 7-hydroxy-DHEA, from DHEA itself.

Priority: FR20030004282 Applic. Date: 2003-04-07; WO2004FR00847 Applic. Date: 2004-04-06

Inventor: CRITON MARC [FR]; GLOUX DAMIEN [FR]; MONTERO JEAN-LOUIS [FR]


Application No.: US20070032475A1  Published: 08/Feb/2007

Title: Novel compounds useful for bradykinin B1 receptor antagonism

Applicant/Assignee:

Application No.: 11/398711   Filing Date: 06/Apr/2006

Abstract:Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.

Priority: US20050671537P Applic. Date: 2005-04-15

Inventor: YE XIAOCONG M [US]; GAROFALO ALBERT W [US]; LAWLER ROSE D [US]; FUKUDA JURI Y [US]; KONRADI ANDREI W [US]; HOLCOMB RYAN [US]; ROSSITER KASSANDRA I [US]; WONE DAVID W [US]; WU JING [US]


Application No.: US20070032476A1  Published: 08/Feb/2007

Title: Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof

Applicant/Assignee: CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Application No.: 11/390480   Filing Date: 28/Mar/2006

Abstract:The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (cancers and precancers, dermatological, rheumatic and ophthalmological complaints in particular) or in cosmetic compositions. The invention also relates to a pharmaceutical or cosmetic composition, characterized in that it comprises, as active agent, a compound of general formula (I) in combination with a pharmaceutically or cosmetically acceptable support.

Priority: FR20000007029 Applic. Date: 2000-05-31; US2003-296927 Applic. Date: 2003-05-06; WO2001FR01694 Applic. Date: 2001-05-31

Inventor: FOURNET GUY [FR]; QUASH GERARD A [FR]; GORE JACQUES [FR]


Application No.: US20070032543A1  Published: 08/Feb/2007

Title: Combinations of substituted 1,3-diphenylprop-2-EN-1-one derivatives with other therapeutically active ingredients

Applicant/Assignee: GENFIT

Application No.: 11/493040   Filing Date: 26/Jul/2006

Abstract:The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives and combinations of said derivatives with other therapeutically active ingredients. The invention also concerns compositions comprising said derivatives or said combinations and uses thereof, for the treatment of cerebrovascular diseases, pathology related to inflammation, neurodegeneration, deregulations of lipid and/or glucose metabolism, cell proliferation and/or differentiation and/or skin or central nervous system ageing.

Priority: FR20020008571 Applic. Date: 2002-07-08; US2005-520079 Applic. Date: 2005-04-22; WO2003FR02127 Applic. Date: 2003-07-08

Inventor: DELHOMEL JEAN F [FR]; CAUMONT-BERTRAND KARINE [FR]


Application No.: US20070036653A1  Published: 15/Feb/2007

Title: Control of power, loads and/or stability of a horizontal axis wind turbine by use of variable blade geometry control

Applicant/Assignee: FORSKNINGSCENTER RISO TECHNICAL UNIVERSITY OF DENMARK

Application No.: 10/551406   Filing Date: 31/Mar/2004

Abstract:The present invention relates to a design concept by which the power, loads and/or stability of a wind turbine may be controlled by typically fast variation of the geometry of the blades using active geometry control (e.g. smart materials or by embedded mechanical actuators), or using passive geometry control (e.g. changes arising from loading and/or deformation of the blade) or by a combination of the two methods. The invention relates in particular to a wind turbine blade, a wind turbine and a method of controlling a wind turbine.

Priority: DK20030000491 Applic. Date: 2003-03-31; WO2004DK00225 Applic. Date: 2004-03-31

Inventor: BAK DAN C [DK]; BUHL THOMAS [DK]; FUGLSANG PETER [DK]; MADSEN HELGE A [DK]; RASMUSSEN FLEMMING [DK]


Application No.: US20070036731A1  Published: 15/Feb/2007

Title: Topical Delivery with a Carrier Fluid

Applicant/Assignee: COLLEGIUM PHARMACEUTICAL, INC

Application No.: 11/464100   Filing Date: 11/Aug/2006

Abstract:Aerosol spray formulations capable of delivering high concentrations of active agent-containing materials and/or excipient are described herein. The formulation contains a carrier fluid, a propellant, and a therapeutic, prophylactic, consmeticeutical and/or inert solid suspended, dissolved, or dispersed in the formulation. The active ingredient may be any pharmaceutically active agent, but is preferably an antibiotic, an antihistamine, an anesthetic, an anti-inflammatory, and/or an astringent. In one embodiment, the active agent is an antifungal agent. In another embodiment, the active agent is a consmeticeutical. The active agent can optionally be dispersed on, or associated with, a carrier powder. The carrier fluid is a highly volatile silicone liquid, which evaporates in less than 10 minutes, preferably less than 5 minutes, after application of the formulation to the patient's skin. The formulation may also contain one or more pharmaceutically acceptable excipients such as antioxidants, stabilizers, perfumes, colorants, viscosifiers, emulsifiers, surfactants, and combinations thereof. The formulation can be packaged in a conventional aerosol spray can.

Priority: US20050708286P Applic. Date: 2005-08-13; US20060797186P Applic. Date: 2006-05-03; US20060813658P Applic. Date: 2006-06-14

Inventor: HIRSH JANE C [US]; GURGE RONALD M [US]; HIRSH MARK [US]; TRUMBORE MARK W [US]


Application No.: US20070037752A1  Published: 15/Feb/2007

Title: Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases

Applicant/Assignee:

Application No.: 10/575882   Filing Date: 15/Oct/2004

Abstract:The invention relates to substances which specifically inhibit peptidases splitting ala-p-nitroanilide for use in medicine. The invention further relates to the use of at least one such substance or of a pharmaceutical or cosmetic composition containing at least one such substance for the prophylaxis and therapy of diseases, in particular the prophylaxis and therapy of diseases with an overshooting immune response (autoimmune diseases, allergies and transplant rejections), of other chronic inflammatory diseases, neuronal diseases and brain damages, skin diseases (acne and psoriasis, among others), tumor diseases and special virus infections (including SARS).

Priority: DE20031048023 Applic. Date: 2003-10-15; WO2004EP11643 Applic. Date: 2004-10-15

Inventor: ANSORGE SIEGFRIED [DE]; BANK UTE [DE]; NORDHOFF KARSTEN [DE]; TAEGER MICHAEL [DE]; STRIGGOW FRANK [DE]


Application No.: US20070037753A1  Published: 15/Feb/2007

Title: Inhibitors of cancer cell, T-cell and keratinocyte proliferation

Applicant/Assignee: 4SC AG

Application No.: 11/501722   Filing Date: 10/Aug/2006

Abstract:The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is -NRR, -NRC-ONRR-NRC-SNRR, -NRC-NRNR, heterocycle, -C-ONRR, heterocycle, or aryl

n is 0 to 8

m is 0, or 1

r is 0 to 3

t is 0 to 3

X is O or N

Z is CH2, C-O, C-S or a single bond

Z<1 >is CO-R<2>, CS-R<2>, (CH2)t-R<2 >or the side-chain of a naturally occuring amino acid

, Z<2 >is CO-R<2>, CS-R<2 >or (CH2)t-R<3 >or the side-chain of a naturally occuring amino acid

Z<3 >is CO-R<2>, CS-R<2 >or (CH2)t-R<4 >or the side-chain of a naturally occuring amino acid

Z<4 >is H, alkyl, alkoxy, or cycloalkyl

R<1>, R<2>, R<3>, and R<4 >are independently from each other H, OH, SH, NH2, CN, NO2, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylamino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen.

Priority: US20050706877P Applic. Date: 2005-08-10

Inventor: LEBAN JOHANN [DE]; KRALIK MARTIN [AT]


Application No.: US20070037777A1  Published: 15/Feb/2007

Title: Lipid-containing compositions and methods of using them

Applicant/Assignee: IMMUNOPATH PROFILE, INC

Application No.: 11/501380   Filing Date: 09/Aug/2006

Abstract:Anabolic compositions can be administered to patients with chronic diseases, or who suffer from conditions precipitated by such diseases or long term treatment regimes. The compositions comprise at least one surfactant wherein the total concentration of surfactant in the composition is greater than 1% (w/w or w/v), and can cause weight gain in chronic disease patients as well as reduce or eliminate other disease symptoms or conditions. The anabolic compositions can also provide therapeutic benefit in patients who are candidates for, or who have undergone, organ or tissue transplant procedures.

Priority: US20050707571P Applic. Date: 2005-08-12

Inventor: GIRSH LEONARD S [US]


Application No.: US20070037781A1  Published: 15/Feb/2007

Title: Novel combinations of medicaments for the treatment of respiratory diseases containing long-acting beta-agonists and at least one additional active ingredient

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/424558   Filing Date: 16/Jun/2006

Abstract:Disclosed are medicament combinations which contain in addition to one or more, preferably one, compound of general formula 1 wherein the groups X, R, R, R<1>, R<1'>, R<2>, R<2'>, R<2''>, R<2'''>, V and n may have the meanings given in the claims and in the specification, at least one other active substance 2, processes for preparing them and their use as pharmaceutical compositions.

Priority: DE200510030733 Applic. Date: 2005-07-01

Inventor: KONETZKI INGO [DE]; BOUYSSOU THIERRY [DE]; PESTEL SABINE [DE]; SCHNAPP ANDREAS [DE]


Application No.: US20070037785A1  Published: 15/Feb/2007

Title: Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, infammatory, neuronal, and other diseases

Applicant/Assignee:

Application No.: 10/575883   Filing Date: 15/Oct/2004

Abstract:The present invention relates to substances capable of specifically inhibiting Gly-Pro-p-nitroanilide cleaving peptidases, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).

Priority: DE20031048022 Applic. Date: 2003-10-15; WO2004EP11645 Applic. Date: 2004-10-15

Inventor: ANSORGE SIEGFRIED [DE]; BANK UTE [DE]; NORDHOFF KARSTEN [DE]; TAEGER MICHAEL [DE]; STRIGGOW FRANK [DE]


Application No.: US20070037788A1  Published: 15/Feb/2007

Title: Tricyclic steroid hormone nuclear receptor modulators

Applicant/Assignee: ELI LILLY AND COMPANY

Application No.: 10/576761   Filing Date: 08/Dec/2004

Abstract:The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof

pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient

and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).

Priority: US20030531283P Applic. Date: 2003-12-19; WO2004US38233 Applic. Date: 2004-12-08

Inventor: GAVARDINAS KONSTANTINOS [US]; GREEN JONATHAN E [US]; JADHAV PRABHAKAR K [US]; MATTHEWS DONALD P [US]


Application No.: US20070037825A1  Published: 15/Feb/2007

Title: Enhancing the effect of radioimmunotherapy in the treatment of tumors

Applicant/Assignee:

Application No.: 10/521299   Filing Date: 17/Jul/2003

Abstract:4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used for enhancing the effect of radioimmunotherapy of tumors.

Priority: US20020397347P Applic. Date: 2002-07-19; WO2003IB03257 Applic. Date: 2003-07-17

Inventor: BARANOWSKA-KORTYLEWICZ JANINA [US]; KURIZAKI TAKASHI [JP]; ABE MICHIO [US]; OSTMAN ARNE [SE]; PIETRAS KRISTIAN [SE]


Application No.: US20070037857A1  Published: 15/Feb/2007

Title: Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors

Applicant/Assignee: UNIVERSITY OF MONTPELLIER II LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ZENTARIS GMBH UNIVERSITY OF MONTPELLIER I

Application No.: 11/502473   Filing Date: 11/Aug/2006

Abstract:The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance

short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake

adipogenesis, adiposity and/or obesity

body weight gain and/or reduction

diabetes, diabetes type I, diabetes type II, tumor cell proliferation

inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Priority: EP20050017732 Applic. Date: 2005-08-16; US20060787543P Applic. Date: 2006-03-31; US20050707941P Applic. Date: 2005-08-15

Inventor: PERRISSOUD DANIEL [DE]; MARTINEZ JEAN [FR]; MOULIN ALINE [FR]; FEHRENTZ JEAN-ALAIN [FR]; BOEGLIN DAMIEN [FR]; DEMANGE LUC [FR]


Application No.: US20070037880A1  Published: 15/Feb/2007

Title: Pharmaceutical compositions comprising ascorbic acid for the treatment of fungal superinfections and fungal recurrances

Applicant/Assignee:

Application No.: 10/563912   Filing Date: 21/May/2004

Abstract:The present invention is directed to compositions containing ascorbic acid or a physiologically acceptable salt thereof for the preparation of a formulation useful for the prevention of fungal infection recurrences or fungal superinfections in patients at risk.

Priority: EP20030077314 Applic. Date: 2003-07-22; WO2004EP05559 Applic. Date: 2004-05-21

Inventor: MAILLAND FEDERICO [IT]


Application No.: US20070041927A1  Published: 22/Feb/2007

Title: Skin cleansing agent, particularly for removing printing inks and/or soiling caused by ink

Applicant/Assignee: STOCKHAUSEN GMBH

Application No.: 10/572574   Filing Date: 29/Apr/2005

Abstract:The invention relates to a skin cleansing agent, particularly for the removal of printing colors and/or inks, comprising the components a) 1 to 70 wt.-% of at least one ethoxylated amine and/or ethoxylated diamine, b) 30 to 70 wt.-% of at least one polyethylene glycol of general formula H-O-(CH2CH2-O)nH, wherein n is an integer of from 1 to 150, c) 1 to 30 wt.-% of at least one fatty alcohol polyglycol ether, d) 0.1 to 5 wt.-% of at least one complexing agent, e) 0 to 30 wt.-% of at least one reducing or oxidizing agent, f) 0 to 25 wt.-% of one or more abrasives, g) 0 to 10 wt.-% of at least one polyhydric alcohol, h) 0 to 3 wt.-% water, i) optionally one or more viscosity-building agents, j) optionally further cosmetic adjuvants, additives and/or active substances, the sum of components a) through j) making 100 wt.-%, relative to the composition of the cleansing agent.

Priority: DE200410026684 Applic. Date: 2004-05-28; WO2005EP04633 Applic. Date: 2005-04-29

Inventor: BLAESER EDELTRAUD [DE]; VEEGER MARCEL [DE]; ZUR MUEHLEN ANNETTE [DE]; THOERNER BRIGITTE [DE]


Application No.: US20070041937A1  Published: 22/Feb/2007

Title: G-csf derivative for inducing immunological tolerance

Applicant/Assignee: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

Application No.: 10/568995   Filing Date: 20/Aug/2004

Abstract:The invention relates to a method, composition and use thereof for inducing immunological tolerance, in particular transplantation tolerance in a recipient and self-tolerance in a patient. Tolerance is preferably induced by administering a G-CSF derivative, or biologically active fragment, homolog or variant thereof, in particular peg-G-CSF, to a transplantation donor. Transplantation tolerance may reduce or prevent graft versus host disease or graft rejection and self-tolerance may prevent, treat or improve a condition in relation to an autoimmune disorder. The invention also relates to expanding and stimulating selected donor cells by administering a G-CSF derivative, preferably peg-G-CSF. The donor cells are preferably granulocyte-monocyte precursors cells and IL-10 secreting T cells.

Priority: AU20030904541 Applic. Date: 2003-08-22; WO2004AU01116 Applic. Date: 2004-08-20

Inventor: HILL GEOFFREY [AU]; MACDONALD KELLIE [AU]; MORRIS EDWARD [GB]


Application No.: US20070041949A1  Published: 22/Feb/2007

Title: Ultrasonic modification of soft tissue matrices

Applicant/Assignee: THE UNIVERSITY OF LEEDS

Application No.: 10/557779   Filing Date: 14/May/2004

Abstract:The present invention provides a method of, and apparatus for, utilising ultrasonic energy so as to mechanically disrupt the collagenous architecture of biological matrices in a controlled manner so that the tissue can be rapidly recellularised in continuous form. The present invention also provides for the production of tissue matrices with improved recellularisation properties, cell stratification or patterning.

Priority: GB20030011800 Applic. Date: 2003-05-22; WO2004GB02055 Applic. Date: 2004-05-14

Inventor: FISHER JOHN [GB]; INGHAM ELLEEN [GB]


Application No.: US20070041960A1  Published: 22/Feb/2007

Title: Apparatus and methods for enzymatic debridement of skin lesions

Applicant/Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD., ENZYSURGE LTD

Application No.: 11/493381   Filing Date: 25/Jul/2006

Abstract:An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.

Priority: WO2005IL00101 Applic. Date: 2005-01-27; US2004-768749 Applic. Date: 2004-01-27

Inventor: FREEMAN AMIHAY [IL]; HIRSZOWICZ ERAN [IL]; BE ERI-LIPPERMAN MICHAL [IL]


Application No.: US20070041996A1  Published: 22/Feb/2007

Title: Aromatase activating agent

Applicant/Assignee: KAO CORPORATION

Application No.: 11/580127   Filing Date: 13/Oct/2006

Abstract:The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, and phellodendron bark

or chlorella

or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.

Priority: JP20020355578 Applic. Date: 2002-12-06; US2003-725451 Applic. Date: 2003-12-03

Inventor: KAKUO SHINGO [JP]; MORIWAKI SHIGERU [JP]; OHUCHI ATSUSHI [JP]; KUSUOKU HIROSHI [JP]


Application No.: US20070042026A1  Published: 22/Feb/2007

Title: Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions

Applicant/Assignee:

Application No.: 11/083178   Filing Date: 17/Mar/2005

Abstract:Botanically derived anti-irritants for prophylactic and therapeutic treatment of adverse skin reactions from application of transdermal or topical drug delivery system, permits the effective administration of a drug from a delivery system in which the drug, of a component of the delivery system comprises a skin irritant

and the delivery systems formed thereby.

Priority:

Inventor: WILLE JOHN J [US]


Application No.: US20070042028A1  Published: 22/Feb/2007

Title: Plaster causing reduced skin irritation

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 11/509612   Filing Date: 25/Aug/2006

Abstract:A plaster containing an active ingredient for the transdermal administration of a pharmaceutical active ingredient, having a removable protective film and an adhesive layer. The plaster includes at least one compound that is contained in the adhesive layer or lies adjacent the adhesive layer between the adhesive layer and the removable protective film and that can be applied to the skin to at least reduce skin irritation.

Priority: DE200410009903 Applic. Date: 2004-02-26; WO2005EP02032 Applic. Date: 2005-02-25

Inventor: KUGELMANN HEINRICH [DE]; BARTHOLOMAUS JOHANNES [DE]; SEDAGHAT KERDAR RASOUL [DE]


Application No.: US20070042030A1  Published: 22/Feb/2007

Title: Preparation for the application of agents in mini-droplets

Applicant/Assignee: IDEA AG

Application No.: 11/481804   Filing Date: 05/Jul/2006

Abstract:The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.

Priority: DE19904026833 Applic. Date: 1990-08-24; DE19904026834 Applic. Date: 1990-08-24; DE19914107153 Applic. Date: 1991-03-06; DE19914107152 Applic. Date: 1991-03-06; WO1991EP01596 Applic. Date: 1991-08-22; US2000-621574 Applic. Date: 2000-07-21; US1992-844664 Applic. Date: 1992-04-08

Inventor: CEVC GREGOR [DE]


Application No.: US20070042032A1  Published: 22/Feb/2007

Title: Self forming, thermodynamically stable liposomes and their applications

Applicant/Assignee: BIOZONE LABORATORIES, INC

Application No.: 11/588068   Filing Date: 24/Oct/2006

Abstract:Certain diacylglycerol-polyethyleneglycol (DAG-PEG) lipids are especially useful for forming thermodynamically stable liposomes. Such liposomes are useful for a variety of purposes, including the delivery of therapeutic agents.

Priority: US2005-178001 Applic. Date: 2005-07-08; US2002-262284 Applic. Date: 2002-09-30; US2000-745292 Applic. Date: 2000-12-20

Inventor: KELLER BRIAN C [US]; LASIC DAN D [US]; LASIC ALENKA [US]


Application No.: US20070042034A1  Published: 22/Feb/2007

Title: High drug load formulations and dosage forms

Applicant/Assignee: MYRIAD GENETICS, INCORPORATED

Application No.: 11/491771   Filing Date: 24/Jul/2006

Abstract:The invention relates to high drug load formulations containing (R)-2-(2-fluoro-4-biphenylyl)propionic acid as an active pharmaceutical ingredient.

Priority: US20050701710P Applic. Date: 2005-07-22; US20050706344P Applic. Date: 2005-08-08

Inventor: ZENTNER GAYLEN M [US]; MCREA JAMES C [US]; WILLIAMS MARK S [US]; OEHRTMAN GREGORY T [US]; POWERS TRACY A [US]


Application No.: US20070042997A1  Published: 22/Feb/2007

Title: Medicament for treatment of dermal pigmentation

Applicant/Assignee:

Application No.: 10/564407   Filing Date: 16/Jul/2004

Abstract:A medicament for preventive and/or therapeutic treatment of dermal pigmentation and/or development of skin cancer, which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in a main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a heteroaryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above.

Priority: JP20030197807 Applic. Date: 2003-07-16; WO2004JP10558 Applic. Date: 2004-07-16

Inventor: ITAI AKIKO [JP]; MUTO SUSUMU [JP]


Application No.: US20070043109A1  Published: 22/Feb/2007

Title: Slimming cosmetic composition

Applicant/Assignee: SEDERMA SAS

Application No.: 10/557616   Filing Date: 19/May/2004

Abstract:Cosmetic or dermopharmaceutical compositions containing, in a dermatologically acceptable carrier, at least one diterpene among: cafestol, kahweol and chemical derivatives are useful for slimming treatments including prevent and/or treat cellulite or orange peel and/or to refine contours of the face, skin firming, to reduce the steatomery of the thighs, to decrease the volume/fatty overload of the spare tire at the hips, to reduce "love handles", both on men and women.

Priority: FR20030006063 Applic. Date: 2003-05-20; JP20040052321 Applic. Date: 2004-02-26; WO2004IB50755 Applic. Date: 2004-05-19

Inventor: LINTER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]


Application No.: US20070043113A1  Published: 22/Feb/2007

Title: Novel compounds

Applicant/Assignee: TANABE SEIYAKU CO., LTD

Application No.: 10/581723   Filing Date: 17/Dec/2004

Abstract:The present invention relates to novel phenylalanine compounds, processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

Priority: GB20030029584 Applic. Date: 2003-12-20; WO2004JP19455 Applic. Date: 2004-12-17

Inventor: WARD ROBERT W [GB]; PRADET CHARLOTTE [GB]; ANDREWS IAN P [GB]


Application No.: US20070044810A1  Published: 01/Mar/2007

Title: Method of enhanced drug application

Applicant/Assignee: JR CHEM, LLC

Application No.: 11/476954   Filing Date: 28/Jun/2006

Abstract:Methods of treating skin in need thereof are disclosed including applying a drug or active agent or formulation thereof to the skin of a user and applying a sealer thereto. The methods are useful in actively enhancing penetration of the actives immediately upon application to skin, sealing the skin surface to prevent removal of the drug or active agent, holding the drug or active agent in a reservoir film, and/or enhancing long term penetration of the drug or active agent.

Priority: US20050695026P Applic. Date: 2005-06-29

Inventor: RAMIREZ JOSE E [US]; FARYNIARZ JOSEPH R [US]


Application No.: US20070048245A1  Published: 01/Mar/2007

Title: Cosmetic composition to accelerate repair of functional wrinkles

Applicant/Assignee:

Application No.: 11/504119   Filing Date: 15/Aug/2006

Abstract:The present invention relates to a composition consisting of a combination of peptides that regenerate the dermal matrix and a rapid acting muscle relaxant derived from the extract of the plant, Acemella oleracea. By limiting cutaneous deformation caused by the contraction of facial muscles the extract increases the efficiency of the peptides in reducing expression lines.

Priority: US20050713454P Applic. Date: 2005-09-01

Inventor: BELFER WILLIAM A [US]


Application No.: US20070048301A1  Published: 01/Mar/2007

Title: Compositions and methods for the treatment of immune related diseases

Applicant/Assignee:

Application No.: 10/533520   Filing Date: 24/Nov/2003

Abstract:The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US20020429069P Applic. Date: 2002-11-26; WO2003US35971 Applic. Date: 2003-11-24

Inventor: BODARY-WINTER SARAH C [US]; CLARK HILARY [US]; HUNTE BRISDELL [US]; JACKMAN JENET K [US]; SCHOENFELD JILL R [US]; WILLIAMS P M [US]


Application No.: US20070048355A1  Published: 01/Mar/2007

Title: Non-irritating solvent-borne polymeric coatings for application to the skin

Applicant/Assignee:

Application No.: 11/213655   Filing Date: 26/Aug/2005

Abstract:A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and/or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35 DEG C. and less than 150 DEG C., and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.

Priority:

Inventor: PERLMAN DANIEL [US]


Application No.: US20070048356A1  Published: 01/Mar/2007

Title: Antimicrobial treatment of nonwoven materials for infection control

Applicant/Assignee:

Application No.: 11/216341   Filing Date: 31/Aug/2005

Abstract:A material substrate having at least part of a surface treated with an antimicrobial composition is described. The antimicrobial composition exhibits at least a 3 log10 CFU reduction within a period of about 30 minutes after contact with various species of a broad spectrum of microorganisms. The substrate can be a nonwoven material that has good fluid barrier properties, which can be used in protective garments and sheets. Methods for manufacturing and imparting the antimicrobial treatment to the substrate are also provided.

Priority:

Inventor: SCHORR PHILLIP A [US]; HOFFMAN DOUGLAS R [US]; KOENIG DAVID W [US]; SPENCER ANTHONY S [US]; YAHIAOUI ALI [US]; DOBSON ANGELA G [US]


Application No.: US20070048360A1  Published: 01/Mar/2007

Title: Pharmaceutical compositions with melting point depressant agents and method of making same

Applicant/Assignee:

Application No.: 11/506368   Filing Date: 17/Aug/2006

Abstract:The invention relates to the use of chemical fragrance ingredient to lower the melting point of active agents, thereby changing crystalline active agents into an amorphous state. The invention also relates to methods of enhancing the transdermal or transmucosal skin permeation or skin penetration of pharmacologically active agents to patients in need thereof. The compositions of the present invention present the additional benefits of being substantially alcohol-free and having a pleasant olfactory profile.

Priority: US20050710959P Applic. Date: 2005-08-23

Inventor: R CARRARA DARIO N [CH]; GRENIER ARNAUD [FR]; ALBERTI INGO [FR]; ROGUE CHRISTELLE [FR]; BESSE CELINE [FR]; LAETITIA HENRY [FR]


Application No.: US20070048361A1  Published: 01/Mar/2007

Title: Patches and uses thereof

Applicant/Assignee: DBV TECHNOLOGIES

Application No.: 11/411531   Filing Date: 26/Apr/2006

Abstract:A patch comprising a support having electrostatic properties is provided wherein a periphery of the support is coated with an adhesive material, and all or part of the non-adhesive surface of the support is covered with at least one biologically active substance in the form of particles that is adhered to the non-adhesive part of the support by electrostatic forces.

Priority: FR20010003382 Applic. Date: 2001-03-13; US2003-659566 Applic. Date: 2003-09-10; WO2002FR00804 Applic. Date: 2002-03-06

Inventor: DUPONT CHRISTOPHE [FR]; DUPONT BERTRAND [FR]; VANNEROM PIERRE-YVES [FR]; BENHAMOU PIERRE-HENRI [FR]; RONCO JORGE [FR]


Application No.: US20070049512A1  Published: 01/Mar/2007

Title: Rapid dissolving bar soap with fibrous assembly

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER

Application No.: 11/218180   Filing Date: 01/Sep/2005

Abstract:A cleansing article composed of a solid or semi-solid foamable composition, a wear promotion agent and a fibrous layer with bonded fibers is described that provides the user with a pleasant personal cleansing experience by revealing sufficient free fibers during personal cleansing to provide both excellent lather and exfoliating properties and which in one embodiment combines cleansing, aesthetic and/or skin benefit with active agents. The batting layer is at least partially encompassed by the solid or semi-solid foamable composition.

Priority:

Inventor: KEENAN DIANE M [US]; GRISSETT GREGORY A [US]; MACEDO FILOMENA A [US]; WILLIAMS DAVID R [US]


Application No.: US20070049514A1  Published: 01/Mar/2007

Title: Resonance modulator for diagnosis and therapy

Applicant/Assignee:

Application No.: 10/547223   Filing Date: 27/Feb/2004

Abstract:A method and device are disclosed for monitoring and/or altering an immune function. The method uses a resonance modulating compound as a coupling agent that is capable of interacting with the immune system to monitor or stimulate immune function. The resonance modulator has electromagnetic properties that attract immune cells to a target area to which the resonance modulating agent has been applied. Electromagnetic properties (such as a voltage amplitude) of the target region are altered in the presence of the resonance modulator, and serve as an indicator of immune function. An external stimulus (such as an applied electromagnetic field) can also be applied to the resonance modulator to enhance its immune stimulating and attractant properties. Particular examples of the resonance modulator are aryl hydrazones. The described aryl nitrohydrazones have the ability to interact with populations of cells with emergent behavioral characteristics associated with chemical, biological and radiation changes and injury. The disclosure also provides numerous other examples of resonance modulating agents, and provides attributes of these agents and assays for identifying additional resonance modulating agents.

Priority: US20030450877P Applic. Date: 2003-02-28; WO2004US05845 Applic. Date: 2004-02-27

Inventor: MORGAN LEE ROY R [US]


Application No.: US20070049572A1  Published: 01/Mar/2007

Title: Novel agents for preventing and treating disorders involving modulation of the RyR receptors

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 11/212413   Filing Date: 25/Aug/2005

Abstract:The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases

exercise-induced irregular heartbeat disorders and diseases

sudden cardiac death

exercise-induced sudden cardiac death

congestive heart failure

chronic obstructive pulmonary disease

and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia

atrial and ventricular fibrillation

atrial and ventricular tachyarrhythmia

atrial and ventricular tachycardia

catecholaminergic polymorphic ventricular tachycardia (CPVT)

and exercise-induced variants thereof.

Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

Priority:

Inventor: MARKS ANDREW R [US]; LANDRY DONALD W [US]; DENG SHIXIAN [US]; CHENG ZHEN Z [US]; LEHNART STEPHAN E [US]


Application No.: US20070049618A1  Published: 01/Mar/2007

Title: Isoindole-imide compounds and compositions comprising and methods of using the same

Applicant/Assignee:

Application No.: 11/513563   Filing Date: 30/Aug/2006

Abstract:This invention relates to isoindole-imide compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US20050712387P Applic. Date: 2005-08-31

Inventor: MULLER GEORGE W [US]; CHEN ROGER S [US]; MAN HON-WAH [US]; RUCHELMAN ALEXANDER L [US]


Application No.: US20070049831A1  Published: 01/Mar/2007

Title: Confocal Raman Spectroscopy for dermatological studies

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/510898   Filing Date: 28/Aug/2006

Abstract:Use of Confocal Raman Spectroscopy (CRS) for dermatological studies, including a method for determining the thickness of the Stratum Corneum (SC) on a test area of the skin, and to a method for quantifying the effectiveness of a skin care composition. The methods of the invention can be carried in vitro (either artificial skin or a sample of skin) or in vivo (directly on the human skin of a person).

Priority: EP20050018928 Applic. Date: 2005-08-31

Inventor: CROWTHER JONATHAN M [GB]; BLENKIRON PETER [GB]; MATTS PAUL J [GB]; SIEG ANKE [GB]


Application No.: US20070049901A1  Published: 01/Mar/2007

Title: Method of treating acne with stratum corneum piercing device

Applicant/Assignee:

Application No.: 11/409454   Filing Date: 21/Apr/2006

Abstract:The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device that contains at east one stratum corneum-piercing microprotrusion and a compressible cover such that the compressible cover substantially encases the at least one stratum corneum-piercing microprotrusion, and wherein upon contacting the skin with the compressible cover, the at least one stratum corneum-piercing microprotrusion protrudes from the compressible cover and pierces the stratum corneum of the skin.

Priority: US2005-113890 Applic. Date: 2005-04-25; US2005-113937 Applic. Date: 2005-04-25; US2005-113952 Applic. Date: 2005-04-25

Inventor: WU JEFFREY M [US]; LIU JUE C [US]; SUN YING [US]; MCDONOUGH JUSTIN [US]; LAMBINO DANILO [AU]; MAGHRIBI MARIAM [US]


Application No.: US20070049919A1  Published: 01/Mar/2007

Title: Radiofrequency ablation with independently controllable ground pad conductors

Applicant/Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION

Application No.: 11/214398   Filing Date: 29/Aug/2005

Abstract:A radiofrequency ablation system provides multiple ground pads and active control of current flow through the ground pads to provide improved power sharing at the tissue near the ground pads reducing risk of patient skin burns for higher power ablation generators.

Priority: US20040569896P Applic. Date: 2004-05-11; WO2005US16172 Applic. Date: 2005-05-09

Inventor: LEE FRED T JR [US]; WINTER THOMAS C III [US]; HAEMMERICH DIETER G [AT]; SAMPSON LISA A [US]; GOLDBERG S N [US]


Application No.: US20070050202A1  Published: 01/Mar/2007

Title: Business method for generating advertising claims

Applicant/Assignee:

Application No.: 11/449937   Filing Date: 09/Jun/2006

Abstract:Business method for generating advertising claims by utilizing Confocal Raman Spectroscopy (CRS) for dermatological studies. The methods of the invention can be carried in vitro (either artificial skin or a sample of skin) or in vivo (directly on the human skin of a person).

Priority: EP20050018928 Applic. Date: 2005-08-31

Inventor: CROWTHER JONATHAN M [GB]; SIEG ANKE [GB]; MATTS PAUL J [GB]; BLENKIRON PETER [GB]


Application No.: US20070051376A1  Published: 08/Mar/2007

Title: Composition for cushions, wounds dressings and other skin-contacting products

Applicant/Assignee: A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS, RUSSIAN ACADEMY OF SCIENCES CORIUM INTERNATIONAL, INC

Application No.: 11/594461   Filing Date: 07/Nov/2006

Abstract:A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings, adhesive cushions, and transdermal drug delivery devices.

Priority: US2002-227623 Applic. Date: 2002-08-21; US20020383504P Applic. Date: 2002-05-24

Inventor: KULICHIKHIN VALERY G [RU]; PARANDOOSH SHOREH [US]; FELDSTEIN MIKHAIL M [RU]; ANTONOV SERGEY [RU]; CLEARY GARY W [US]


Application No.: US20070053858A1  Published: 08/Mar/2007

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/412354   Filing Date: 27/Apr/2006

Abstract:Personal care composition comprising a vitamin B3 compound, a sugar amine, a hydroquinone compound, and a dermatologically-acceptable carrier.

Priority: US2002-097716 Applic. Date: 2002-03-13; US20010277805P Applic. Date: 2001-03-22

Inventor: TANNER PAUL R [US]; BISSETT DONALD L [US]; ELSBROCK ROBERT J [US]


Application No.: US20070053863A1  Published: 08/Mar/2007

Title: Cosmetic composition comprising extract form mallotus japonicus for improving skin wrinkle

Applicant/Assignee:

Application No.: 10/575869   Filing Date: 16/Apr/2004

Abstract:The present invention relates to compositions for inhibiting elastase activity, enhancing collagen biosynthesis and improving skin wrinkle, comprising Mallotus japonicus extract as active ingredient. The present compositions exhibit the inhibition effect on elastase activity and promotion effect on collagen biosynthesis at a molecular level, and as a result, excellent efficacy in improvement of skin wrinkles.

Priority: KR20030074764 Applic. Date: 2003-10-24; WO2004KR00881 Applic. Date: 2004-04-16

Inventor: LEE JUNG NO [KR]; JEONG JEE HEAN [KR]; KEE BYONG [KR]; LEE KANG-TAE [KR]


Application No.: US20070053884A1  Published: 08/Mar/2007

Title: Novel adult tissue-derived stem cell and use thereof

Applicant/Assignee: KEIO UNIVERSITY

Application No.: 10/557053   Filing Date: 14/May/2004

Abstract:Subjects of the present invention are to establish a technology for separating, isolating and culturing a stem cell derived from adult tissue while retaining the in vivo properties thereof, and to provide a preventive and/or therapeutic agent for diseases which accompany tissue injury, which comprises a stem cell derived from adult tissue as an active ingredient. In order to solve the subjects, the present invention provides a stem cell derived from adult tissue which is CD45-negative and CXCR4-positive. Also, the present invention provides a preventive and/or therapeutic agent for diseases which accompany tissue injury, which comprises the stem cell as an active ingredient.

Priority: JP20030139605 Applic. Date: 2003-05-16; JP20030351168 Applic. Date: 2003-10-09; JP20030419400 Applic. Date: 2003-12-17; WO2004JP06912 Applic. Date: 2004-05-14

Inventor: SUDA TOSHIO [JP]; HIRAO ATSUSHI [JP]; ARAI FUMIO [JP]; SAKURADA KAZUHIRO [JP]; YAMADA YOJI [JP]; ANDO HIROSHI [JP]; SATO HIDETAKA [JP]; YOKOYAMA HIROMI [JP]; ISHIHARA MASAHIKO [JP]


Application No.: US20070053894A1  Published: 08/Mar/2007

Title: Compound and method for regulating plasminogen activation and cell migration

Applicant/Assignee: TRANSFERT PLUS

Application No.: 10/556145   Filing Date: 07/May/2004

Abstract:The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for treating cancer and thrombo-embolic diseases such as heart stroke. Furthermore, the present invention relates to novel pharmaceutical compositions form regulating cell migration, plasminolysis, angiogenesis and for treating cancer. In particular, the present invention relates to a method of regulating the activation of plasminogen comprising contacting a solution of pro-urokinase (uPA) or tissue plasminogen activator (tPA) and plasminogen with melanotransferrin (p97) for a time sufficient to effect regulation thereof.

Priority: US20030469000P Applic. Date: 2003-05-09; WO2004CA00697 Applic. Date: 2004-05-07

Inventor: BELIVEAU RICHARD [CA]; DEMEULE MICHEL [CA]; BERTRAND YANICK [CA]; MICHAUD-LEVESQUE JONATHAN [CA]; ROLLAND YANNEVE [CA]; JODOIN JULIE [CA]


Application No.: US20070053898A1  Published: 08/Mar/2007

Title: Method for reducing allergencity in indoor spaces

Applicant/Assignee: MEDACHIEVE, INC

Application No.: 11/529586   Filing Date: 29/Sep/2006

Abstract:According to this invention, allergenicity in an indoor space is reduced by denaturing allergens in allergen reservoirs that are capable of producing respiratory or skin reactions and physically removing the allergens from the allergen reservoirs in the indoor space. The allergen reservoirs may also be treated with pesticides and fungicides/fungistats to prevent reinfestation of house dust mites, molds and cockroaches.

Priority: US2005-239473 Applic. Date: 2005-09-30; US2002-153612 Applic. Date: 2002-05-24; US20010293183P Applic. Date: 2001-05-25

Inventor: PAYTON HUGH W [US]


Application No.: US20070053960A1  Published: 08/Mar/2007

Title: Multiribbon nanocellulose as a matrix for wound healing

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 11/513564   Filing Date: 31/Aug/2006

Abstract:The present invention includes compositions and methods for the integration of a non-allergenic nanocellulose into a wound bed. The composition may be formed into a wide variety of implants, e.g., a suture, a sheet, a compress, a bandage, a band, a prosthesis, a fiber, a woven fiber, a bead, a strip, a clasp, a prosthesis, a catheter, a screw, a bone plate, a pin, a bandage or combinations thereof.

Priority: US20050712951P Applic. Date: 2005-08-31

Inventor: BROWN R M JR [US]; CZAJA WOJCIECH [US]; JESCHKE MARC [US]; YOUNG DAVID J [US]


Application No.: US20070053965A1  Published: 08/Mar/2007

Title: Kit comprising a plaster, optionally containing an active substance, and an agent that at least partially reduces skin irritation

Applicant/Assignee: GRUENENTHAL GMBH

Application No.: 11/509613   Filing Date: 25/Aug/2006

Abstract:A kit comprising a plaster, which contains a pharmaceutical active ingredient and is designed to administer the active ingredient transdermally to a human or animal to which the plaster is applied, and an agent that is separate from the plaster and at least reduces skin irritation from the plaster.

Priority: WO2005EP02033 Applic. Date: 2005-02-25

Inventor: KUGELMANN HEINRICH [DE]; BARTHOLOMAEUS JOHANNES [DE]; SEDAGHAT KERDAR RASOUL [DE]


Application No.: US20070053968A1  Published: 08/Mar/2007

Title: Transdermal drug delivery devices containing O-Desmethyl Venlafaxine (ODV) or its salts

Applicant/Assignee: WYETH

Application No.: 11/515708   Filing Date: 05/Sep/2006

Abstract:The present invention provides transdermal drug delivery devices (i.e., patches) comprising O-desmethylvenlafaxine (ODV), a selective serotonin and norepinephrine re-uptake inhibitor, or a pharmaceutically acceptable salt thereof, which, among other, offer the advantage of eliminating or reducing the adverse side effects associated with the oral administration of ODV. Also provided are methods of preparing and using these transdermal delivery systems for the treatment of depression, anxiety disorders, vasomotor symptoms and pain.

Priority: US20050714582P Applic. Date: 2005-09-07

Inventor: TATAPUDY RAO [US]; SHAH SYED M [US]


Application No.: US20070053978A1  Published: 08/Mar/2007

Title: Process for co-spray drying liquid herbal extracts with dry silicified MCC

Applicant/Assignee:

Application No.: 11/593760   Filing Date: 07/Nov/2006

Abstract:A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.

Priority: US2002-256855 Applic. Date: 2002-09-27; US20010334443P Applic. Date: 2001-11-30; US20010334398P Applic. Date: 2001-11-29

Inventor: SHERWOOD BOB [US]; ZELEZNIK JOSEPH A [US]; SCHAIBLE DAVID [US]; BARKULIN WILHEIM [DE]; THEISSING KARL-HANS [DE]


Application No.: US20070054843A1  Published: 08/Mar/2007

Title: Methods for treatment of headaches by administration of oxytocin

Applicant/Assignee:

Application No.: 11/511997   Filing Date: 28/Aug/2006

Abstract:The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.

Priority: US20050711950P Applic. Date: 2005-08-26; US20060794004P Applic. Date: 2006-04-21

Inventor: YEOMANS DAVID C [US]; ANGST MARTIN S [US]; FREY WILLIAM H II [US]; JACOBS DANIEL I [US]


Application No.: US20070054933A1  Published: 08/Mar/2007

Title: 17-Heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/569302   Filing Date: 02/Sep/2004

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies,

cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030501789P Applic. Date: 2003-09-10; WO2004US28655 Applic. Date: 2004-09-02

Inventor: KAUFMAN MILDRED L [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20070054958A1  Published: 08/Mar/2007

Title: Compounds for treatment of lipase-mediated diseases

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD

Application No.: 11/222901   Filing Date: 08/Sep/2005

Abstract:Novel benzoquinone-derived compounds and polymorphs, prodrugs, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, and metabolic disorders are provided. Methods of use of the compounds for skin care, hair care and cosmetics are provided.

Priority:

Inventor: UPADHYAY SHAKTI [IN]; YADAV RAMAN [IN]; GANGAN VIJAY [IN]; KANEKAR YOGESH [IN]


Application No.: US20070054964A1  Published: 08/Mar/2007

Title: Topical formulations containing O-Desmethyl Venlafaxine (ODV) or its salts

Applicant/Assignee: WYETH

Application No.: 11/515702   Filing Date: 05/Sep/2006

Abstract:The present invention provides topical compositions comprising O-desmethylvenlafaxine (ODV), a selective serotonin and norepinephrine re-uptake inhibitor, or a pharmaceutically acceptable salt thereof. In certain embodiments, the inventive topical formulations contain one or more percutaneous/permucosal absorption enhancers. Also provided are methods of preparing and using these compositions for the treatment of diseases or conditions where a localized therapeutic effect is sought, such as vasomotor symptoms and pain.

Priority: US20050715400P Applic. Date: 2005-09-07

Inventor: TATAPUDY RAO [US]; SHAH SYED M [US]


Application No.: US20070055216A1  Published: 08/Mar/2007

Title: Olfactory patch

Applicant/Assignee:

Application No.: 11/430098   Filing Date: 09/May/2006

Abstract:An olfactory patch comprises a well 6 formed by a reservoir layer 2 , the well sandwiched between a barrier layer 3 and a permeable layer 4 . The permeable layer defines a pathway for olfactory fluid flow from the well 6 (B, FIG. 2 ). The flow of the olfactory may be commenced by an initiator mechanism, the same or another mechanism may control or terminate the flow of olfactory. The olfactory patch may utilise any olfactory fluid or combination of fluids within the same patch. The patch may utilise olfactory fluid which provides aromas or masks odours or has de-deodorising capability or the olfactory fluid contains therapeutic agents which are released from the patch by aromatization or by direct skin absorption or by inhalation.

Priority: GB20050018253 Applic. Date: 2005-09-08

Inventor: RASHID ASRAR [GB]


Application No.: US20070059253A1  Published: 15/Mar/2007

Title: Foamable pharmaceutical compositions and methods for treating a disorder

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 11/595864   Filing Date: 13/Nov/2006

Abstract:Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

Priority: US2003-445487 Applic. Date: 2003-05-28

Inventor: POPP KARL F [US]; YUHAS EDWARD R [US]


Application No.: US20070059259A1  Published: 15/Mar/2007

Title: Compositions and methods for mitigating skin irritation

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 11/223665   Filing Date: 09/Sep/2005

Abstract:The invention relates to a composition and a method for mitigating redness or inflammation of mammalian skin comprising administering to mammalian skin a composition consisting of an effective amount of alkanolamine, feverfew or soy or mixtures thereof, one or more optional benefit agents and one or more cosmetically acceptable carriers. More particularly, it relates to a composition for mitigating skin irritations such as retinol/retinoid irritation and their applications to mammalian skin.

Priority:

Inventor: TIERNEY NEENA [US]; MARTIN KATHARINE [US]; MITCHELL PHYLLIS [US]; SOUTHALL MICHAEL [US]


Application No.: US20070059262A1  Published: 15/Mar/2007

Title: Solid skin care composition comprising multiple layers

Applicant/Assignee:

Application No.: 11/517697   Filing Date: 08/Sep/2006

Abstract:The present invention relates to a solid skin care composition comprising: (a) a first layer which is solid at 45 DEG C. and which is selected from the group consisting of a water-in-oil emulsion, an oil-in-water emulsion and an oil dispersion

and (b) a second layer which is a pressed powder layer

wherein the first layer and the second layer are provided in the same package in a manner such that the first layer and the second layer can be simultaneously applied.

Priority: US20050715685P Applic. Date: 2005-09-09

Inventor: TANIGUCHI TOSHIYA [JP]


Application No.: US20070059263A1  Published: 15/Mar/2007

Title: Solid skin care composition comprising multiple layers

Applicant/Assignee:

Application No.: 11/517981   Filing Date: 08/Sep/2006

Abstract:The present application relates to a solid skin care composition comprising: (a) a first layer which is solid at 45 DEG C. and which is a water-in-oil emulsion or an oil-in-water emulsion

and (b) a second layer which is solid at 45 DEG C. and which is an oil dispersion comprising a benefit agent

and wherein the first layer and the second layer are provided in the same package in a manner such that the first layer and the second layer can be simultaneously applied.

Priority: US20050715687P Applic. Date: 2005-09-09

Inventor: TANIGUCHI TOSHIYA [JP]; SAKO TAKASHI [JP]; FUJIWARA YOKO [JP]; FUJII KIYOHIKO [JP]; WATANABE NOBUO [JP]


Application No.: US20070059268A1  Published: 15/Mar/2007

Title: COMPOSITIONS, METHODS AND KITS FOR TREATING ALLERGIC DERMATITIS OF SKIN

Applicant/Assignee:

Application No.: 11/464986   Filing Date: 16/Aug/2006

Abstract:The invention includes compositions suitable for removal of urushiol from skin having been exposed thereto, which compositions contain an ethoxylate and sodium lauroyl sarcosinate, methods for treating allergic dermatitis of skin having been exposed to urushiol, and kits suitable for treatment of allergic dermatitis,

Priority: US20050715647P Applic. Date: 2005-09-09

Inventor: MAGEE LAURA [US]


Application No.: US20070059269A1  Published: 15/Mar/2007

Title: Administration of 8-hexadecene-1,16-dicarboxylic acid for promoting cohesion of the epidermal horny layer

Applicant/Assignee: L'OREAL

Application No.: 11/505477   Filing Date: 17/Aug/2006

Abstract:A regime or regimen for promoting cohesion and/or organization of the epidermal horny layer, notably for promoting homogeneity and/or clarity of the complexion, for improving the homogeneity and/or the staying power of makeup compositions on the skin or the lips, for preventing impairment of the horny layer induced by a cosmetic or dermatological active agent, or for promoting cohesion of the horny layer in the preparation of reconstructed epidermis and/or reconstructed skin, entails administering to an individual in need of such treatment, for such period of time as required to elicit the desired effect, a cosmetic/dermatological composition which contains up to 8% by weight of 8-hexadecene-1,16-dicarboxylic acid, formulated into a physiologically acceptable medium therefor.

Priority: FR20050052526 Applic. Date: 2005-08-17; US20050716127P Applic. Date: 2005-09-13

Inventor: BERNARD DOMINIQUE [FR]; MAHE YANN [FR]


Application No.: US20070059300A1  Published: 15/Mar/2007

Title: COMPOUNDS AND COMPOSITIONS TO CONTROL ABNORMAL CELL GROWTH

Applicant/Assignee: ZOLTAN LABORATORIES LLC

Application No.: 11/461916   Filing Date: 02/Aug/2006

Abstract:Methods and regimens for stimulating proliferation and inhibiting death of skin cells in wounded, non-wounded healthy and unhealthy, or transplanted skin and skin cell suspensions are provided. The methods and regimens include a step of administering to an area of host skin and/or transplanted skin a combination of lactoferrin and alkaline phosphatase such as placental alkaline phosphatase. The active components may be administered topically, by injection, or by other suitable means. In addition to improving the quality of skin, the reported methods may also be effective to reduce inflammation and microbial infection in the skin. Embodiments of the invention also provide compositions suitable for use in the described methods.

Priority: US20050716346P Applic. Date: 2005-09-12; US20050732165P Applic. Date: 2005-10-31

Inventor: KISS ZOLTAN [US]


Application No.: US20070059351A1  Published: 15/Mar/2007

Title: Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods

Applicant/Assignee:

Application No.: 11/366207   Filing Date: 01/Mar/2006

Abstract:The present invention is drawn to a transdermal patch for the delivery of a nitric oxide-donor and a second active agent. The patch can comprise a backing layer and an active agent-containing composition which is supported at least in part by the backing layer. The active agent-containing composition can include an amount of a nitric oxide-donor and an amount of a second active agent. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 mug/hour to about 85 mug/hour. The second active agent can be selected from a number of agents including NSAIDS, opioids, local anesthetics, menthol, salicylic acid, salicylic acid derivatives, vanilloid receptor-1 activators, corticosteroids, vasoconstrictors, and combinations thereof.

Priority: US2004-967707 Applic. Date: 2004-10-15; US20030512070P Applic. Date: 2003-10-17

Inventor: MURRELL GEORGE A C [AU]; ANG ROBERT [US]; JACOBSON SVEN [US]; GELIEBTER DAVID [US]


Application No.: US20070059679A1  Published: 15/Mar/2007

Title: Method for demonstrating efficacy of a topically applied active ingredient

Applicant/Assignee:

Application No.: 11/222887   Filing Date: 09/Sep/2005

Abstract:A method is disclosed for demonstrating the efficacy of a topically applied active ingredient, which method includes topically applying a composition containing an active ingredient to an area of skin, applying an absorbent material to the area of skin to extract at least a portion of the active ingredient from the skin, thereby incorporating the portion of active ingredient with the absorbent material in a releasable manner, removing the absorbent material from the skin, extracting the active ingredient from the absorbent material, combining the extracted active ingredient with cellular growth media, incubating the cellular growth media with cultured cells for a period of time to produce a biomarker, and measuring the biomarker to indicate efficacy of the active ingredient.

Priority:

Inventor: GARAY MICHELLE [US]; SOUTHALL MICHAEL [US]


Application No.: US20070060558A1  Published: 15/Mar/2007

Title: Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Application No.: 11/516692   Filing Date: 07/Sep/2006

Abstract:The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q-(Y1)p-(U)p-(Y2)p-A: wherein Q represents an aminoquinoline, (Y1)p(U)p-(Y2)p'' is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

Priority: FR20040008441 Applic. Date: 2004-07-30; US2004-019450 Applic. Date: 2004-12-23; WO2005FR01937 Applic. Date: 2005-07-26

Inventor: SANCHEZ MURIEL [FR]; MEUNIER BERNARD [FR]


Application No.: US20070060650A1  Published: 15/Mar/2007

Title: Solid skin care composition comprising multiple layers

Applicant/Assignee:

Application No.: 11/517749   Filing Date: 08/Sep/2006

Abstract:The present invention relates to a solid skin care composition comprising: (a) a first layer which is solid at 45 DEG C. and which is a water-in-oil emulsion

and (b) a second layer which is solid at 45 DEG C. and which is an oil-in-water emulsion comprising a benefit agent

wherein the first layer and the second layer have a different composition

and wherein the first layer and the second layer are provided in the same package in a manner such that the first layer and the second layer can be simultaneously applied.

Priority: US20050715684P Applic. Date: 2005-09-09

Inventor: TANIGUCHI TOSHIYA [JP]; SAKO TAKASHI [JP]; FUJIWARA YOKO [JP]; FUJII KIYOHIKO [JP]; WATANABE NOBUO [JP]


Application No.: US20070060666A1  Published: 15/Mar/2007

Title: Solid skin care composition comprising multiple layers

Applicant/Assignee:

Application No.: 11/517696   Filing Date: 08/Sep/2006

Abstract:Disclosed is a solid skin care composition comprising: (a) a first layer which is solid at 45 DEG C. and which is a water-in-oil emulsion

and (b) a second layer which is solid at 45 DEG C. and which is a water-in-oil emulsion comprising a benefit agent

wherein the first layer and the second layer have a different composition

and wherein the first layer and the second layer are provided in the same package in a manner such that the first layer and the second layer can be simultaneously applied.

Priority: US20050715686P Applic. Date: 2005-09-09

Inventor: TANIGUCHI TOSHIYA [JP]; SAKO TAKASHI [JP]; FUJIWARA YOKO [JP]; FUJII KIYOHIKO [JP]; WATANABE NOBUO [JP]


Application No.: US20070060867A1  Published: 15/Mar/2007

Title: High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances

Applicant/Assignee:

Application No.: 11/510078   Filing Date: 25/Aug/2006

Abstract:A method of usign a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.

Priority: US2005-908584 Applic. Date: 2005-05-18

Inventor: XU BAI [US]


Application No.: US20070061899A1  Published: 15/Mar/2007

Title: Transgenic mammal with constitutive, tissue-specific cytokine expression and use as a cancer model

Applicant/Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Application No.: 11/404226   Filing Date: 13/Apr/2006

Abstract:The invention is directed to a transgenic non-human mammal with constitutive, tissue-specific cytokine expression and the use of the transgenic mammal as a model for spontaneous development of cancer. Particularly, the invention provides for a transgenic mouse where specific expression of interlueukin-1beta in the stomach results in the development of gastric cancer. The invention also encompasses methods using the transgenic mammals for screening compounds for their ability to modulate the development, growth or progression of cancer.

Priority: US20050670911P Applic. Date: 2005-04-13; US20050705429P Applic. Date: 2005-08-04

Inventor: WANG TIMOTHY C [US]


Application No.: US20070065381A1  Published: 22/Mar/2007

Title: Skin care composition

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/228766   Filing Date: 16/Sep/2005

Abstract:Skin care composition comprising a plurality of interference pigments and a dermatologically acceptable carrier. The plurality comprises at least a first interference pigment which reflects a first color, and at least a second interference pigment which reflects a second, complementary color. The total amount of interference pigments is from about 0.1% to about 10%.

Priority:

Inventor: ELSBROCK ROBERT J [US]; TANNER PAUL R [US]; JONES JULIET A [US]


Application No.: US20070065382A1  Published: 22/Mar/2007

Title: Cosmetic composition comprising at least one active agent and particles containing at least one colored inorganic pigment in a matrix, and skincare use thereof

Applicant/Assignee:

Application No.: 11/520760   Filing Date: 14/Sep/2006

Abstract:Disclosed herein is a cosmetic composition for treating and/or caring for the skin, which comprises, in a physiologically acceptable medium, at least one cosmetic active agent and at least one colored particle comprising at least one inorganic pigment arranged inside a matrix, wherein the composition has an opacity of less than or equal to 35%. Also disclosed herein is a cosmetic treatment process comprising applying this composition to keratin materials. Further disclosed herein is a method for lightening and/or unifying the complexion of the skin and/or for correcting the appearance of skin marks and dyschromias comprising applying a composition of the present disclosure to the skin.

Priority: FR20050009370 Applic. Date: 2005-09-14

Inventor: CASSIN GUILLAUME [FR]


Application No.: US20070065383A1  Published: 22/Mar/2007

Title: High alcohol content foaming compositions with silicone-based surfactants

Applicant/Assignee:

Application No.: 11/520819   Filing Date: 14/Sep/2006

Abstract:This invention relates to a "high lower alcohol content" (>40% v/v of a C1-4 alcohol) liquid composition able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers. The liquid compositions comprise a C1-4 alcohol, (>40% v/v), a silicone-based surfactant of at least 0.001% by weight for foaming to prepare a foamable composition, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Priority: WO2006CA00320 Applic. Date: 2006-03-07; US20050658580P Applic. Date: 2005-03-07

Inventor: FERNANDEZ DE CASTRO MARIA T [US]; KOIVISTO BRUCE M [US]; MUNOZ FRANCISCO [US]


Application No.: US20070065386A1  Published: 22/Mar/2007

Title: Use of oligosaccharides in cosmetic, food or dermatological compositions for stimulating the differentiation of epidermal cell

Applicant/Assignee:

Application No.: 10/555532   Filing Date: 06/May/2004

Abstract:The present invention related to a method for preventing or treating skin disorders comprising administering to a subject a dermatological composition comprising oligogalacturonides.

Priority: FR20030005511 Applic. Date: 2003-05-06; WO2004FR01101 Applic. Date: 2004-05-06

Inventor: LUBRANO CHRISTIAN [FR]; LE BATTEUX NATHALIE [FR]


Application No.: US20070065395A1  Published: 22/Mar/2007

Title: Topical compositions containing plant extracts for personal care

Applicant/Assignee:

Application No.: 11/229186   Filing Date: 16/Sep/2005

Abstract:A topical composition or a personal beauty care product (e.g., soap, shampoo, rinse, hair conditioner, and the like) comprises chemical or biological substances or plant extracts obtained from certain plants, in particular, plant species of the family Liliaceae or Amaryllidaceae, preferably selected from the following Allium species such as Allium fistulosum, Allium ampeloprasum or Allium porrum, or other Allium species or their relative species having ingredients which can stimulate hair growth and/or reduce hair loss. The plant species can preferably be selected from bunching onion, scallion, Welsh onion, green onion, great green onion, spring onion, leek, wild leek, Egyptian leek, shallot, and Korean or Asian great green onion, or the like.

Priority:

Inventor: KIM JUNG J [KR]


Application No.: US20070065417A1  Published: 22/Mar/2007

Title: Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof

Applicant/Assignee: UNIVERSITY OF PITTSBURGH

Application No.: 11/505735   Filing Date: 17/Aug/2006

Abstract:The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

Priority: US2000-549937 Applic. Date: 2000-04-14; US1999-302896 Applic. Date: 1999-04-30; US19980083917P Applic. Date: 1998-05-01

Inventor: CHANCELLOR MICHAEL B [US]; HUARD JOHNNY [US]; CAPELLI CHRISTOPHER C [US]; QU ZHUQING [US]


Application No.: US20070065463A1  Published: 22/Mar/2007

Title: Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions

Applicant/Assignee:

Application No.: 10/560889   Filing Date: 21/Jun/2004

Abstract:The invention is directed to topical formulations and methods of treating a migraines and/or cluster headaches, muscle sprains, muscle spasms, spasticity, tension headaches, tension related migraines and related conditions associated with muscle tension and pain with a therapeutically effective amount of an ergot alkaloid, skeletal muscle relaxant, serotonin agonist, combinations thereof, pharmaceutically acceptable salt thereof, prodrugs thereof or derivative thereof.

Priority: US20030480089P Applic. Date: 2003-06-20; US20030480088P Applic. Date: 2003-06-20; US20030513082P Applic. Date: 2003-10-21; WO2004US19816 Applic. Date: 2004-06-21

Inventor: AUNG-DIN RONALD [US]


Application No.: US20070065472A1  Published: 22/Mar/2007

Title: Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers

Applicant/Assignee: L'OREAL

Application No.: 11/476053   Filing Date: 28/Jun/2006

Abstract:The benzyl-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate thereof

are useful active agents for inducing and/or stimulating the growth of mammalian keratin fibers and/or reducing the loss and/or increasing the density thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for caring for or making up the hair or the eyelashes.

Priority: FR20050051789 Applic. Date: 2005-06-28; US20050697966P Applic. Date: 2005-07-12

Inventor: BOULLE CHRISTOPHE [FR]; DALKO MARIA [FR]


Application No.: US20070065503A1  Published: 22/Mar/2007

Title: Active substance-doped absorbing polymer particles, composition comprising polycondensate matrix and absorbant polymer for release of a wound treatment substance

Applicant/Assignee: STOCKHAUSEN GMBH

Application No.: 10/563747   Filing Date: 01/Jul/2004

Abstract:A water-absorbing composition, a process for producing a water-absorbing composition, a composite comprising a water-absorbing composition, and the use of a water-absorbing composition for releasing an active substance (e.g., a wound treatment substance, a care substance, or combinations thereof) are disclosed. A water-absorbing composition can include active substance-doped water-absorbing polymer particles comprising: Phi1.) an active substance in a quantity in the range from about 0.001 to about 30 wt. %

and Phi2.) an absorber matrix in a quantity in the range from about 70 to about 99.999 wt. %. Also, a hygiene article and a wound treatment means, including a water-absorbing composition, are disclosed.

Priority: DE20031030960 Applic. Date: 2003-07-08; WO2004EP07140 Applic. Date: 2004-07-01

Inventor: HARREN JORG [DE]; NIELINGER URSULA [DE]; OPPENBERG DIETER [DE]; SCHMIDT HARALD [DE]


Application No.: US20070066499A1  Published: 22/Mar/2007

Title: Self-supporting aerosol cleansing composition

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER

Application No.: 11/229751   Filing Date: 19/Sep/2005

Abstract:An aerosol cleansing composition that is self-supporting after dispensing is described whose volume does not noticeably shrink with time. The inventive composition can be used in place of toilet bars when it is inconvenient to use such bars and provides the user with substantial lather and optionally warming agents, skin conditioners and/or skin active agents. A method for cleansing the skin without rinsing with water is also disclosed where the inventive aerosol cleansing composition is applied to the skin and wiped off.

Priority:

Inventor: SLAVTCHEFF CRAIG S [US]; BRENNAN MICHAEL A [US]; MERAVIGLIA SANDRA D [US]; GOLDBERG JESSICA W [US]; MASSARO MICHAEL [US]


Application No.: US20070066512A1  Published: 22/Mar/2007

Title: Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels

Applicant/Assignee:

Application No.: 11/519732   Filing Date: 11/Sep/2006

Abstract:Methods of treating, preventing and/or managing disorders associated with low plasma leptin levels are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active agent.

Priority: US20050715582P Applic. Date: 2005-09-12

Inventor: VERHELLE DOMINIQUE [US]; CHAN KYLE [US]; BRADY HELEN [US]


Application No.: US20070066552A1  Published: 22/Mar/2007

Title: Topical administration permitting prolonged exposure of target cells to therapeutic and prophylactic nucleic acids

Applicant/Assignee: INTROGEN THERAPEUTICS, INC

Application No.: 11/336664   Filing Date: 20/Jan/2006

Abstract:Compositions and methods for preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid comprised in a solid or semi-solid formation or in a transdermal or transcutaneous delivery device are disclosed. Also disclosed are compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include an adhesive. Compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid uptake enhancer are also disclosed. Methods of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that involve these therapeutic compositions and devices are also disclosed.

Priority: US20050645826P Applic. Date: 2005-01-21; US20050692481P Applic. Date: 2005-06-21

Inventor: CLARKE PETER [US]; CHADA SUNIL [US]; MENANDER KERSTIN [US]; SOBOL ROBERT E [US]; ZHANG SHUYUAN [US]


Application No.: US20070066646A1  Published: 22/Mar/2007

Title: Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof

Applicant/Assignee: GENMEDICA THERAPEUTICS SL

Application No.: 11/461782   Filing Date: 02/Aug/2006

Abstract:This invention is directed to inhibitors of copper-containing amine oxidases (E.C. 1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO

also known as vascular adhesion protein-1, VAP-1), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.

Priority: US20050704557P Applic. Date: 2005-08-02

Inventor: CLAUZEL LUC M [ES]; FONT FRANCESC Y [ES]; VICENTE SILVIA G [ES]; EXPOSITO MIRIAM ROYO [ES]; PALOMERA FERNANDO A [ES]; OLARTE ANTONIO Z [ES]


Application No.: US20070067177A1  Published: 22/Mar/2007

Title: QUALITY ASSURANCE SYSTEM AND METHODS OF USE

Applicant/Assignee: TEMPTIME CORPORATION

Application No.: 11/468127   Filing Date: 29/Aug/2006

Abstract:A quality assurance system having an ambient condition indicator provides a current visual indication of the cumulative exposure over time of a host product to an ambient condition such as temperature or humidity. The indicator's visual response is correlated with the response characteristics of any one of a wide range of specific host products including foods, drugs and vaccines, industrial and other products whose quality is related to condition-exposure over time. The system includes a historical record with one or more historical visual indications of past cumulative exposures. An airline meal can be accompanied by a novel freshness certification document which can simulate a travel document and provide, in a graphically appealing manner, a verified indication of the freshness of the meal served. Also disclosed are a novel quality assurance document and method and a cold chain monitor.

Priority: US20050712929P Applic. Date: 2005-08-31

Inventor: MARTIN JEAN-PAUL [GB]; GOZLAN SERGE P [FR]; PRUSIK THADDEUS [US]; CAULFIELD CHRISTOPHER [US]


Application No.: US20070071675A1  Published: 29/Mar/2007

Title: Dual variable domain immunoglobulin and uses thereof

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 11/507050   Filing Date: 18/Aug/2006

Abstract:The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Priority: US20050709911P Applic. Date: 2005-08-19; US20050732892P Applic. Date: 2005-11-02

Inventor: WU CHENGBIN [US]; GHAYUR TARIQ [US]; DIXON RICHARD W [US]; SALFELD JOCHEN G [US]


Application No.: US20070071688A1  Published: 29/Mar/2007

Title: Pharmaceutical compositions for transdermal administration of anti-inflammatory agents

Applicant/Assignee: SANOFI-AVENTIS

Application No.: 11/549168   Filing Date: 13/Oct/2006

Abstract:A pharmaceutical composition for transdermal administration comprising a polymeric release matrix capable of forming a supple film after drying, selected among cellulose polymers or copolymers

an active principle selected among the group of non-steroid anti-inflammatory agents comprising at least one carboxylic or metal carboxylate group

a transcutaneous absorption promoter

water

and a physiologically acceptable non-aqueous solvent capable of dissolving the release matrix, the active principle and the transcutaneous absorption promoter and to be rapidly eliminated by evaporation on contact with the skin.

Priority: FR20000006048 Applic. Date: 2000-05-12; US2002-275801 Applic. Date: 2002-11-08; WO2001FR01442 Applic. Date: 2001-05-11

Inventor: ILLEL BRIGITTE [FR]; VERGNAUD JEAN-PIERRE [FR]


Application No.: US20070071710A1  Published: 29/Mar/2007

Title: EXTRACT OF VANILLA PLANIFOLIA

Applicant/Assignee: CHANEL PARFUMS BEAUTE

Application No.: 11/534888   Filing Date: 25/Sep/2006

Abstract:The invention relates to an extract of vanilla originating from at least one species of vanilla plant (family Orchidaceae), to the method for obtaining it, to a cosmetic or dermatological composition containing it, and to its use as a polyfunctional active agent in a cosmetic or dermatological composition, for the prevention and/or treatment of alterations of the skin due, in particular, to aging, to physiological mechanisms related to aging, or to conditions related to these mechanisms.

Priority: FR20050009765 Applic. Date: 2005-09-23; FR20050009767 Applic. Date: 2005-09-23; US20050748199P Applic. Date: 2005-12-08

Inventor: MAESTRO YANNICK [FR]; LASSERRE CHRISTELLE [US]; BERGIA DANIEL [FR]


Application No.: US20070071729A1  Published: 29/Mar/2007

Title: Dermal fillers for biomedical applications in mammals and methods of using the same

Applicant/Assignee:

Application No.: 11/409024   Filing Date: 24/Apr/2006

Abstract:A method of tissue augmentation in mammals comprising implanting or injecting into the tissue of a mammal elastic material derived from solar elastosis or other sun-damaged sites in humans is disclosed. The method further comprises injecting into the tissue of a mammal, alone, or in combination with the solar elastosis, at least one filler material, such as fibrillin, recombinant fibrillin, fibulin, and recombinant fibulin. A method of treating various skin conditions, such as wrinkles, photoaging, acne scarring, scars, and HIV-associated lipoatrophy, by injecting into the tissue elastic material derived from solar elastosis and/or filler material is also disclosed.

Priority: US20050674314P Applic. Date: 2005-04-25

Inventor: BERNSTEIN ERIC F [US]


Application No.: US20070071978A1  Published: 29/Mar/2007

Title: Cosmetic Composition Containing Thermoplastic Microspheres and Skin Beneficial Agents

Applicant/Assignee:

Application No.: 11/534074   Filing Date: 21/Sep/2006

Abstract:The invention relates to thermoplastic hollow microspheres containing one or more skin benefit agents entrapped therein. The microspheres are useful in the topical delayed release of the skin benefit agent.

Priority: US20050720026P Applic. Date: 2005-09-23

Inventor: SOJKA MILAN F [US]; CUMMINS PHILLIP [US]


Application No.: US20070072260A1  Published: 29/Mar/2007

Title: C1q related protein

Applicant/Assignee: ARES TRADING S.A

Application No.: 10/573936   Filing Date: 27/Oct/2004

Abstract:This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.

Priority: GB20030025038 Applic. Date: 2003-10-27; WO2004GB04544 Applic. Date: 2004-10-27

Inventor: FITZGERALD STEPHEN N [GB]; FAGAN RICHARD J [GB]; POWER CHRISTINE [FR]; YORKE MELANIE [CH]; BIENKOWSKA JADWIGA [MA]


Application No.: US20070072798A1  Published: 29/Mar/2007

Title: Method for treatment of cardiovascular and metabolic diseases and detecting the risk of the same

Applicant/Assignee: OY JURILAB LTD

Application No.: 11/483679   Filing Date: 11/Jul/2006

Abstract:This invention relates to the therapeutic, diagnostic and pharmacogenetic use of nucleic acids and proteins involved in human proteolytical system such as serine and cysteine proteases and their inhibitors and pharmaceutical agents and other therapies affecting these. This invention discloses methods for the treatment and prevention of cardiovascular diseases such as coronary heart disease (CHD), acute myocardial infarction (AMI), chronic CHD, arterial hypertension (HT) and cerebrovascular stroke and metabolic disorders such as the metabolic syndrome (MBO) and obesity and methods for detecting or diagnosing a risk of, or predisposition to the said diseases in a subject, for selecting treatment in a subject and for selecting subjects for studies testing cardiovascular, anti-diabetic and anti-obesity drugs, as well as to transgenic animals.

Priority: US20050698040P Applic. Date: 2005-07-12

Inventor: SALONEN JUKKA T [FI]; TODOROVA BORYANA [FI]; AALTO JUHA-MATTI [FI]; KONTKANEN OUTI [FI]; PIRSKANEN MIA [FI]; UIMARI PEKKA [FI]


Application No.: US20070072802A1  Published: 29/Mar/2007

Title: Peptide nucleic acid based guanidinium compounds

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 11/525482   Filing Date: 21/Sep/2006

Abstract:Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.

Priority: US20050720067P Applic. Date: 2005-09-23

Inventor: ZHAO GANG [US]; KITAURA CHIEKO [JP]; LIU JIAN [US]; YU LEI [US]


Application No.: US20070072808A1  Published: 29/Mar/2007

Title: Antimicrobial and anticancer lipopeptides

Applicant/Assignee: YEDA RESEARCH & DEVELOPMENT CO. LTD

Application No.: 10/560727   Filing Date: 18/Jun/2004

Abstract:The invention provides lipophilic conjugates comprising a peptide coupled to a fatty add, the peptide comprising at least two positively charged amino acid residues, said peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.

Priority: US20030479465P Applic. Date: 2003-06-19; WO2004IL00544 Applic. Date: 2004-06-18

Inventor: SHAI YECHIEL [IL]; AVRAHAMI DORIT [IL]


Application No.: US20070072940A1  Published: 29/Mar/2007

Title: Use of quinol derivatives thereof for cosmetic, dietary supplement or pharmaceutical compositions and compositions thereby obtained.

Applicant/Assignee:

Application No.: 11/162943   Filing Date: 28/Sep/2005

Abstract:The present invention relates to a cosmetic, dietary supplement, or pharmaceutical composition for oral ingestion or topical application to the skin comprising effective amounts of a tocopherol quinone, tocopherol quinol, plastoquinol, menaquinol, or phylloquinol compound, or any combination thereof as a method for preventing free radical oxidation or preventing or treating environmental skin damage including photoaging, trauma, discoloration, dryness, thickness, elasticity, or wrinkles.

Priority:

Inventor: ABRAHAM SAL [US]


Application No.: US20070073210A1  Published: 29/Mar/2007

Title: Wound dressing and adhesive wound dressing comprising a vasoconstrictive ingredient, and processes for the production thereof

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 10/584477   Filing Date: 09/Dec/2004

Abstract:A wound dressing provided as a ready-made product for covering bleeding wounds. The wound dressing comprises a carrier material containing at least one vasoconstrictive medicinal substance.

Priority: DE20031061306 Applic. Date: 2003-12-24; WO2004EP13996 Applic. Date: 2004-12-09

Inventor: HILLE THOMAS [DE]; HOFFMANN CHRISTIAN [DE]


Application No.: US20070077208A1  Published: 05/Apr/2007

Title: PHARMACEUTICAL FOAM

Applicant/Assignee: CONNETICS AUSTRALIA LTD PTY STIEFEL RESEARCH AUSTRALIA, PTY LTD

Application No.: 11/463573   Filing Date: 09/Aug/2006

Abstract:The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized contained comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.

Priority: US2004-763379 Applic. Date: 2004-01-23; US20030454832P Applic. Date: 2003-03-13; US20030442280P Applic. Date: 2003-01-24

Inventor: ABRAM ALBERT Z [AU]; HUNT BARRY T [AU]


Application No.: US20070077273A1  Published: 05/Apr/2007

Title: MICROFABRICATED NANOPORE DEVICE FOR SUSTAINED RELEASE OF THERAPEUTIC AGENT

Applicant/Assignee:

Application No.: 11/530729   Filing Date: 11/Sep/2006

Abstract:A drug delivery device that includes a capsule for implantation into the body

the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.

Priority: US2002-243787 Applic. Date: 2002-09-13; US20010322160P Applic. Date: 2001-09-14; US20020371290P Applic. Date: 2002-04-09

Inventor: MARTIN FRANCIS J [US]; BOIARSKI ANTHONY A [US]


Application No.: US20070078071A1  Published: 05/Apr/2007

Title: Spray dry capsule products and methods for preparing and using same

Applicant/Assignee:

Application No.: 11/240071   Filing Date: 30/Sep/2005

Abstract:The present invention relates to spray-dried compositions comprising encapsulated active materials and a spray-dry carrier, to methods for imparting an effective amount of active materials to spray-dried products and to products incorporating the spray-dried compositions.

Priority:

Inventor: LEE KAIPING [US]; POPPLEWELL LEWIS M [US]


Application No.: US20070078092A1  Published: 05/Apr/2007

Title: Cell permeable conjugates of peptides for inhibition of protein kinases

Applicant/Assignee:

Application No.: 11/295793   Filing Date: 06/Dec/2005

Abstract:The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. The first moiety is joined to the second moiety through a linker or a spacer. The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed.

Priority: IL20030156429 Applic. Date: 2003-06-12; WO2004IL00505 Applic. Date: 2004-06-13

Inventor: LIVNAH NURIT [IL]; LEVITZKI ALEXANDER [IL]; SENDEROVITZ HANOCH [IL]; YECHEZKEL TAMAR [IL]; SALITRA YOSEF [IL]; LITMAN PNINIT [IL]; OHNE OSNAT [IL]


Application No.: US20070078094A1  Published: 05/Apr/2007

Title: Guanidinium delivery carriers

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 11/526224   Filing Date: 22/Sep/2006

Abstract:Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.

Priority: US20050720299P Applic. Date: 2005-09-23

Inventor: ZHAO GANG [US]; YU LEI [US]; LIU JIAN [US]; KITAURA CHIEKO [JP]; WANG XINGHE [US]; CASTELLO CHRIS [US]


Application No.: US20070078130A1  Published: 05/Apr/2007

Title: Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases

Applicant/Assignee:

Application No.: 10/575878   Filing Date: 15/Oct/2004

Abstract:The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).

Priority: DE20031048044 Applic. Date: 2003-10-15; WO2004EP11644 Applic. Date: 2004-10-15

Inventor: ANSORGE SIEGFRIED [DE]; BANK UTE [DE]; TAEGER MICHAEL [DE]; STRIGGOW FRANK [DE]


Application No.: US20070078175A1  Published: 05/Apr/2007

Title: Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof

Applicant/Assignee: L'OREAL

Application No.: 11/543193   Filing Date: 05/Oct/2006

Abstract:Novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds having the following formula and the salts or their solvates thereof: are useful for stimulating or inducing the growth of keratinous fibers and/or slowing down their loss and/or increasing their density and/or improving their appearance, and also for caring for or making up keratinous fibers, e.g., for caring for or making up the hair or eyelashes.

Priority: FR20050053017 Applic. Date: 2005-10-05; US20050726207P Applic. Date: 2005-10-14

Inventor: BOULLE CHRISTOPHE [FR]; DALKO MARIA [FR]


Application No.: US20070078189A1  Published: 05/Apr/2007

Title: Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders

Applicant/Assignee: AUSPEX PHARMACEUTICALS

Application No.: 11/592009   Filing Date: 01/Nov/2006

Abstract:The present invention is directed to novel compounds according to formulae wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

Priority: WO2005US15366 Applic. Date: 2005-05-02; US20040567965P Applic. Date: 2004-05-03

Inventor: SARSHAR SEPEHR [US]


Application No.: US20070078197A1  Published: 05/Apr/2007

Title: Adhesive composition and use of such composition

Applicant/Assignee: COLOPLAST A/S

Application No.: 10/574918   Filing Date: 07/Oct/2004

Abstract:The present invention relates to a pressure sensitive adhesive composition comprising a rubbery elastomeric matrix, said composition comprising one or more amphiphilic block copolymers and the use thereof for application in the medical field for instance for adhering of medical devices to the skin, in wound dressings or ostomy appliances and provides a quick and safe means for managing perspiration from the skin also when occluded with medical appliances.

Priority: DK20030001477 Applic. Date: 2003-10-07; WO2004DK00676 Applic. Date: 2004-10-07

Inventor: SAMUELSEN PETER [DK]


Application No.: US20070078434A1  Published: 05/Apr/2007

Title: Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices

Applicant/Assignee: VYTERIS, INC

Application No.: 11/537182   Filing Date: 29/Sep/2006

Abstract:The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.

Priority: US20050722603P Applic. Date: 2005-09-30

Inventor: KEUSCH PRESTON [US]; REDDY VILAMBI N [IN]; GREENE RICHARD [US]; BASKINGER GEORGE M [US]; SHARMA ASHUTOSH [US]


Application No.: US20070079446A1  Published: 12/Apr/2007

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 10/576915   Filing Date: 25/Oct/2004

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds and selected organic UV filters. The stabilized products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: EP20030104057 Applic. Date: 2003-11-03; WO2004EP52644 Applic. Date: 2004-10-25

Inventor: LUPIA JOSEPH A [CH]; REICH OLIVER [DE]; WILZER KARLA [US]


Application No.: US20070081944A1  Published: 12/Apr/2007

Title: Iontophoresis apparatus and method for the diagnosis of tuberculosis

Applicant/Assignee:

Application No.: 11/540491   Filing Date: 28/Sep/2006

Abstract:An iontophoresis device includes an active electrode assembly including an active electrode element and at least one active agent reservoir. Active agents include one or more polypeptides, or fusion polypeptides, having antigenic determinants derived from or related to M. tuberculosis antigens and suitable for detection of tuberculosis.

Priority: US20050722531P Applic. Date: 2005-09-30

Inventor: REED STEVEN G [US]


Application No.: US20070081953A1  Published: 12/Apr/2007

Title: Surfactant mixtures for improving the deposition of active substances and for reducing the skin irritant action

Applicant/Assignee: IFAC GMBH & CO.KG

Application No.: 10/555414   Filing Date: 06/May/2004

Abstract:A use of mixtures of surfactants which form multilamellar liquid-crystalline structures, where the surfactants are chosen from at least two of the following groups formed from isethionates, taurates, sarcosinates, acyl lactylates, acyl glutamates, fatty acid-protein condensates, PEG stearates, PEG distearates with an HLB value of less than 10, alkyl polyglycosides and betaines for reducing the skin irritant action of cosmetic and/or pharmaceutical formulations which are applied to the skin, and for improving hair structure is described.

Priority: WO2003EP04788 Applic. Date: 2003-05-07; WO2004EP04863 Applic. Date: 2004-05-06

Inventor: DAHMS GERD [DE]


Application No.: US20070081954A1  Published: 12/Apr/2007

Title: Dispersion of polymer particles, composition comprising it and cosmetic treatment method

Applicant/Assignee:

Application No.: 11/543115   Filing Date: 05/Oct/2006

Abstract:The present patent application relates to novel dispersions of particles of a polymer which is stabilized at the surface, in a nonaqueous medium, in which dispersions the polymer exhibits a specific glass transition temperature. Another aspect of the present disclosure is a cosmetic or pharmaceutical composition comprising the said dispersion in a cosmetically or pharmaceutically acceptable medium. The present disclosure also relates to a method for the cosmetic treatment of keratinous substances employing the presently disclosed composition.

Priority: FR20050053032 Applic. Date: 2005-10-06; US20050727515P Applic. Date: 2005-10-18

Inventor: MOUGIN NATHALIE [FR]; JEGOU GWENAELLE [FR]; GIROUD FRANCK [FR]; SAMAIN HENRI [FR]


Application No.: US20070081963A1  Published: 12/Apr/2007

Title: COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING HUMAN GROWTH HORMONE AS AN ACTIVE INGREDIENT

Applicant/Assignee: REGERON, INC

Application No.: 11/279555   Filing Date: 12/Apr/2006

Abstract:Disclosed herein is a skin condition-improving composition for topical application to the skin, comprising human growth hormone as an active ingredient, and a method for improving skin conditions using the same. The disclosed composition exhibits various skin conditioning effects, such as acne treatment, wrinkle improvement, dark spot removal, skin elasticity improvement, hair growth stimulation, skin aging prevention, skin moisturization and the proliferation of skin epidermal stem cells.

Priority: KR20050119008 Applic. Date: 2005-12-07; WO2005KR03402 Applic. Date: 2005-10-12

Inventor: OH DAHL K [KR]; BAIK SANG J [KR]; LEE KYUNG Y [KR]


Application No.: US20070081964A1  Published: 12/Apr/2007

Title: Use of polymers based on n-vinyl caprolactam in hair cosmetics

Applicant/Assignee: BASF AKTIENGESELLSCHAFT PATENTS, TRADEMARKS AND LICENSES

Application No.: 10/582110   Filing Date: 08/Dec/2004

Abstract:Use of polymers of 30-65% by weight of N-vinylcaprolactam, 35-65% by weight of a monomer mixture of N-vinylimidazole and vinylpyrrolidone, where the weight ratio of N-vinylimidazole to vinylpyrrolidone is between 0.085 and 0.30, 0-15% by weight of a nitrogen-containing quaternizable monomer (A), which is different from N-vinylimidazole, where the sum of monomer (A) and N-vinylimidazole is less than 18% by weight, in cosmetic preparations.

Priority: DE20031057532 Applic. Date: 2003-12-08; WO2004EP13977 Applic. Date: 2004-12-08

Inventor: MUELLER GABI [DE]; HOSSEL PETER [DE]; WOOD CLAUDIA [DE]


Application No.: US20070081977A1  Published: 12/Apr/2007

Title: Device for transdermal administration of active substances

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 10/579809   Filing Date: 04/Nov/2004

Abstract:A device for transdermal administration of active substances, comprising a backing layer and an active substance-containing reservoir connected to the backing layer. The skin-facing contact surface of the device has a plurality of microprotrusions which are suitable for penetrating the skin and which are equipped with structures that make extracting the protrusions from the skin more difficult.

Priority: DE20031053629 Applic. Date: 2003-11-17; WO2004EP12458 Applic. Date: 2004-11-04

Inventor: HORSTMANN MICHAEL [DE]


Application No.: US20070082017A1  Published: 12/Apr/2007

Title: Lipid compositions and methods of use

Applicant/Assignee:

Application No.: 10/585705   Filing Date: 09/Jan/2005

Abstract:The present invention relates to a composition comprising: a C12 to C24 branched or unbranched hydrocarbon

a mid-chain triglyceride

a C26 to C36 branched or unbranched hydrocarbon

a cholesteryl ester

an ester of a C10 to C24 fatty acid and a C10 to C20 alcohol

an ester of a C10 to C24 fatty acid and a C21 to C34 alcohol

glycerol

and a polar lipid

and to methods of making and methods of using the composition to treat lipid tear deficiency (LTD), aqueous tear deficiency (ATD), a combination of LTD and ATD, and other dry eye conditions. The composition is substantially free of water and substantially free of an artificial surfactant. A method of administering an ointment comprising a lipid composition to treat dry eye, while achieving sustained release of the ointment and preventing a blurring of vision by the ointment, comprises applying the ointment to the inferior lid margin of the outside skin of the lower eyelid or to the superior lid margin of the outside skin of the upper eyelid, and allowing the ointment to diffuse onto the eye. Also disclosed is the use of kinetic analysis of tear interference images to analyze an individual's precorneal lipid film spread to identify LTD or to evaluate response to LTD treatment in order to adjust percentages of lipids in the composition.

Priority: US20040535597P Applic. Date: 2004-01-10; WO2005US00603 Applic. Date: 2005-01-09

Inventor: TSENG SCHEFFER C [US]


Application No.: US20070082041A1  Published: 12/Apr/2007

Title: Topical delivery of codrugs

Applicant/Assignee: PSIVIDA INC

Application No.: 11/636774   Filing Date: 11/Dec/2006

Abstract:The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.

Priority: US2002-299597 Applic. Date: 2002-11-19; US20010331512P Applic. Date: 2001-11-19

Inventor: WALTERS KENNETH A [GB]; SHIMIZU ROBERT [US]; ASHTON PAUL [US]; CYNKOWSKA GRAZYNA [US]; CYNKOWSKI TADEUSZ [US]; GAUTHIER ERIC [US]


Application No.: US20070086833A1  Published: 19/Apr/2007

Title: Dispenser for personal care composition

Applicant/Assignee:

Application No.: 11/254139   Filing Date: 19/Oct/2005

Abstract:An apparatus for dispensing a personal care composition to the skin includes a container with a reservoir containing the composition. The apparatus has an application end having fibers, with free ends, that provide an application surface.

Priority:

Inventor: GURRISI PAUL [US]


Application No.: US20070086966A1  Published: 19/Apr/2007

Title: Cosmetic product containing mineral water for remineralising and rejuvenating the skin

Applicant/Assignee:

Application No.: 10/555489   Filing Date: 21/May/2004

Abstract:The invention relates to a cosmetic composition that can be used to remineralise human skin and to counteract the effects of ageing on the latter. According to the invention, said composition contains 0.5-3% water of volcanic origin containing 0.01-0.05 mg/l Fe, 100-300 mg/l K, 1,000-2,000 mg/l Na, 80-200 mg/l Mg, 50-150 mg/l Ca, 50-150 mg/l Si, 0.01-0.1 mg/l P, 0.001-0.005 mg/l Se, 0.01-0.03 mg/l Zn. In addition, the composition optionally contains 0.2-0.8% of an extract from samphire Crithmum maritimum, 0.3-0.9% of the peptide palmitoyl-gly-his-lys and 0.8-1.25% hydrolysed soy protein.

Priority: DE20031025158 Applic. Date: 2003-05-28; WO2004EP05543 Applic. Date: 2004-05-21

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]; SICHLING DOROTHEE B [MC]


Application No.: US20070086981A1  Published: 19/Apr/2007

Title: Delivery peptides, their constructs with active agents and use

Applicant/Assignee:

Application No.: 10/579941   Filing Date: 19/Nov/2004

Abstract:The present invention refers to delivery proteins, protein-cargo complexes, methods, and means for the enhanced delivery or transport of drugs, biologically active agents or other compounds as cargo or cargo molecules onto, into, or across biological membranes or tissues forming a biological barrier.

Priority: DE20031055559 Applic. Date: 2003-11-21; WO2004EP13203 Applic. Date: 2004-11-19

Inventor: MEIJER HANS [AE]; WEHLING PETER [DE]


Application No.: US20070088016A1  Published: 19/Apr/2007

Title: Tricyclic steroid hormone nuclear receptor modulators

Applicant/Assignee: ELI LILLY AND COMPANY

Application No.: 10/576901   Filing Date: 15/Dec/2004

Abstract:The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof

pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient

and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).

Priority: US20030530992P Applic. Date: 2003-12-19; WO2004US39767 Applic. Date: 2004-12-15

Inventor: COGHLAN MICHAEL J [US]; JADHAV PRABHAKAR K [US]; DROSTE JAMES J [US]; GREEN JONATHAN E [US]; MATTHEWS DONALD P [US]


Application No.: US20070088024A1  Published: 19/Apr/2007

Title: Active substance combination comprising a carbinol combined to at least an NSAID

Applicant/Assignee: LABORATORIOS DEL DR. ESTEVE S.A

Application No.: 11/543109   Filing Date: 05/Oct/2006

Abstract:The present invention relates to an active substance combination comprising at least one substituted carbinol compound and at least one non-steroidal anti-inflammatory drug (NSAID), a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination for the manufacture of a medicament.

Priority: ES20040000844 Applic. Date: 2004-04-05; WO2005EP03641 Applic. Date: 2005-04-05

Inventor: BUSCHMANN HELMUT H [ES]; GUTIERREZ SILVA BONIFACIO [ES]; HOLENZ JORG [ES]; FARRE GOMIS ANTONIO [ES]


Application No.: US20070088028A1  Published: 19/Apr/2007

Title: 17-Acetamido-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee:

Application No.: 10/557222   Filing Date: 25/Jun/2004

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030483664P Applic. Date: 2003-06-30; WO2004US20753 Applic. Date: 2004-06-25

Inventor: DANKULICH WILLIAM P [US]; MEISSNER ROBERT S [US]; MITCHELL HELEN J [US]


Application No.: US20070088042A1  Published: 19/Apr/2007

Title: Fluorinated 4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee:

Application No.: 11/605090   Filing Date: 28/Nov/2006

Abstract:Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US2004-507239 Applic. Date: 2004-09-09

Inventor: MEISSNER ROBERT S [US]; PERKINS JAMES J [US]


Application No.: US20070088043A1  Published: 19/Apr/2007

Title: Novel HDAC inhibitors

Applicant/Assignee: ORCHID RESEARCH LABORATORIES LIMITED

Application No.: 11/581570   Filing Date: 17/Oct/2006

Abstract:The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel HDAC inhibitors of the general formula (1). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

Priority: IN2005CH01492 Applic. Date: 2005-10-18

Inventor: SRINIVAS AKELLA SATYA S V [IN]; NARASIMHAN KILAMBI [IN]; MANIKANDAN LAKSHMANAN [IN]; RAJAGOPAL SRIRAM [IN]; SELVAKUMAR THANGAPAZHAM [IN]; REDDY GADDAM O [IN]


Application No.: US20070088047A1  Published: 19/Apr/2007

Title: 21-Heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/576335   Filing Date: 27/Oct/2004

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair,

HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20030516425P Applic. Date: 2003-10-31; WO2004US35838 Applic. Date: 2004-10-27

Inventor: DANKULICH WILLIAM P [US]; MITCHELL HELEN J [US]


Application No.: US20070088085A1  Published: 19/Apr/2007

Title: Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

Applicant/Assignee: MELACURE THERAPEUTICS AB

Application No.: 11/639190   Filing Date: 15/Dec/2006

Abstract:The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH

R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide

alkylamino, benzoyloxy, nitroxy, phenyl or sulpho

and the pharmacologically active salts thereof.

Priority: GB20000019357 Applic. Date: 2000-08-07; US2003-343325 Applic. Date: 2003-06-23; WO2001GB03534 Applic. Date: 2001-08-07

Inventor: LUNDSTEDT TORBJORN [SE]; SKOTTNER ANNA [SE]; SEIFERT ELISABETH [SE]


Application No.: US20070092461A1  Published: 26/Apr/2007

Title: Novel Hydroxy Acid Complexes for Antiaging and Skin Renovation

Applicant/Assignee: BIODERM RESEARCH

Application No.: 11/309441   Filing Date: 06/Aug/2006

Abstract:This invention relates to certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including Molybdenum, complexed concurrently with an amino acid, or an equivalent of an amino acid, and a hydroxy acid in a novel spirocyclic bidentate chemical complex form (FIG. 1 ). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation.

The said metal complexes are useful for topical conditions that include dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, age spots, dark circles around eyes, skin pigmentation, topical inflammation, liver spots, pigmented spots, wrinkles, blemishes, skin lines, oily skin, acne, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, dandruff, bacterial infection, fungal infection, wound healing, body odor, and skin changes associated with aging.

Priority: US2002-290933 Applic. Date: 2002-11-07; US2003-439349 Applic. Date: 2003-05-15; US2006-307729 Applic. Date: 2006-02-18

Inventor: GUPTA SHYAM K [US]


Application No.: US20070092466A1  Published: 26/Apr/2007

Title: Compositions and Methods for Treating Hair Loss Using C16-C20 Aromatic Tetrahydro Prostaglandins

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 11/565297   Filing Date: 30/Nov/2006

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2001-774555 Applic. Date: 2001-01-31; US20000193846P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL A [US]; MCIVER JOHN M [US]; YOUNGQUIST ROBERT S [US]


Application No.: US20070092467A1  Published: 26/Apr/2007

Title: Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers

Applicant/Assignee: L'OREAL

Application No.: 11/583792   Filing Date: 20/Oct/2006

Abstract:Oxyacetamide compounds that are inhibitors of type-1 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and which have the formula (I), or salts and/or solvates thereof: are useful for inducing and/or stimulating the growth of human keratin fibers, e.g., human head hair and/or eyelashes, and/or for retarding the loss and/or increasing the density thereof and/or for caring for and/or making up such keratin fibers.

Priority: FR20040004298 Applic. Date: 2004-04-22; WO2005FR00926 Applic. Date: 2005-04-18

Inventor: ROZOT ROGER [FR]; BRETON PHILIPPE [FR]; NEUWELS MICHEL [BE]; BOULLE CHRISTOPHE [FR]


Application No.: US20070092471A1  Published: 26/Apr/2007

Title: Composition for the oxidative treatment of hair or skin fixative compostion and method for permanent deformation of hair

Applicant/Assignee:

Application No.: 10/572790   Filing Date: 15/Oct/2004

Abstract:Cosmetic composition for the oxidative treatment of hair or skin, prepared by mixing of at least two components, in which dehydroascorbic acid or a dehydroascorbic acid salt or a dehydroascorbic acid derivative is generated from ascorbic acid, ascorbic acid derivative and ascorbic acid salt prior to application by an enzyme that catalyzes the enzymatical oxidation of said of ascorbic acid as well as a process for carrying out the oxidative treatment of keratin, particularly for the oxidative post-treatment of reduced hair in the process of permanent deformation of hair using said composition.

Priority: US20030514413P Applic. Date: 2003-10-24; WO2004EP11592 Applic. Date: 2004-10-15

Inventor: CASSIER THORSTEN [DE]; LAUSCHER DIRK [DE]; SCHREIBER BIRGIT [DE]; KILGORE JAMES [US]; ALLWOHN JUERGEN [DE]


Application No.: US20070092476A1  Published: 26/Apr/2007

Title: Compounds and use to reduce the formation of malodour

Applicant/Assignee: GIVAUDAN S.A

Application No.: 11/584686   Filing Date: 20/Oct/2006

Abstract:Malodour formation reducing compounds alpha-N-(3-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, alpha-N-(2-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, and alpha-N-(2,4-Dimethyl-4-phenylbutanoxycarbonyl)-L-glutamine, and their salts, compositions comprising such compounds, including cosmetic products, personal care products, and deodorant products, and methods forming such products and their use. The compounds are useful to reduce the formation of human malodour resulting from bacterial degradation of compounds naturally present in sweat, in particular axilliary malodour.

Priority: US20050729285P Applic. Date: 2005-10-21

Inventor: NATSCH ANDREAS [CH]; FLACHSMANN FELIX [CH]


Application No.: US20070092544A1  Published: 26/Apr/2007

Title: Natural insect repellant

Applicant/Assignee:

Application No.: 11/209529   Filing Date: 23/Aug/2005

Abstract:Disclosed is a pesticide method and composition utilizing a mixture of cedar and cinnamon oils as active pesticide agents in an inert carrier. The composition may also utilize a surfactant. Exemplary embodiments disclosed herein may include up to 8.5% by volume of cedar oil, up to 8.5% cinnamon oil, lemon juice, water, and other ingredients, as desired. Exemplary embodiments may be utilized to repel insects, rodents and other things from humans and animals as well as surfaces and areas that people and pets may be near. The exemplary embodiments may provide this repellant without the harmful effects of other chemicals and repellants.

Priority:

Inventor: MILLS MATTHEW A [US]


Application No.: US20070092546A1  Published: 26/Apr/2007

Title: Thiamin based insect repellant

Applicant/Assignee: VIOLET FIRE, LLC

Application No.: 11/520253   Filing Date: 13/Sep/2006

Abstract:The present invention provides a topical application of thiamin to human skin or mammalian coats to provide effective insect repellency. Any commercially available thiamin compounds such as thiamin hydrochloride or thiamin mononitrate can be combined with a pharmaceutically or cosmetically acceptable carrier for preparing a composition for topical application. This composition and method of application can further be combined with sun-block or sunscreen agents to provide protection against insects as well as the harmful effects of UV radiation. This composition may also contain botanical oils or extracts to mask the thiamin odor and provide repellant synergy.

Priority: US20050729690P Applic. Date: 2005-10-24

Inventor: SPIEGEL LAWRENCE S [US]; SPIEGEL MARY A [US]


Application No.: US20070092571A1  Published: 26/Apr/2007

Title: Non-irritating formulation and method for the intradermal delivery of substances

Applicant/Assignee:

Application No.: 11/256838   Filing Date: 25/Oct/2005

Abstract:This invention describes a composition of matter to facilitate intra-dermal delivery of a great variety of active substances, especially including high molecular weight cosmicuticals. Also disclosed is a method of forming the composition of matter and applying topically to patients, especially using a cream or patch. The active substance is initially combined with a biopolymer, which combination is subsequently linked to a base formulation whereby the base formulation aids in the intra-dermal delivery of the active substance without the skin irritation limitations of other formulations and dermal transmitting methods. The use of a combination of natural herbal, vegetable and animal products combined in this invention with biopolymers permits molecules of higher molecule weight to penetrate into the skin in a bioactive form by passive delivery means. The invention includes a product for the improvement of skin health and wrinkle reduction.

Priority:

Inventor: SCHUR HENRY B [US]


Application No.: US20070093161A1  Published: 26/Apr/2007

Title: Silicone products and methods for making silicone products

Applicant/Assignee:

Application No.: 10/579430   Filing Date: 17/Nov/2004

Abstract:The present invention relates to a silicone product comprising a single or double elastic material which is covered along at least one surface with an adhesive or non-adhesive silicone-gel, wherein the elastic material is woven or knitted and comprises polyamide or polyester.

Priority: NL20031024793 Applic. Date: 2003-11-17; WO2004EP13027 Applic. Date: 2004-11-17

Inventor: EEDE THERESE V D [BE]; BERNARD HOSTE [BE]


Application No.: US20070093551A1  Published: 26/Apr/2007

Title: Hydroxy-oligocarboxylic esters: effects on nerve and use for cutaneous and mucocutaneous organs or sites

Applicant/Assignee:

Application No.: 11/548945   Filing Date: 12/Oct/2006

Abstract:A composition and method for producing a beneficial effect on a subject's nerve associated with at least one of a cosmetic condition, a dermatological indication and a dental indication and another condition. The composition comprises a hydroxy-oligocarboxylic ester and is formulated for topical administration of the product to a subject to produce the beneficial effect. The method includes topically applying to the subject in a region where the beneficial effect is desired a hydroxy-oligocarboxylic ester in an amount effective to produce the beneficial effect.

Priority: US20060759525P Applic. Date: 2006-01-17; US20050727419P Applic. Date: 2005-10-17

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]


Application No.: US20070093646A1  Published: 26/Apr/2007

Title: Crystalline vap-1 and uses thereof

Applicant/Assignee: BIOTIE THERAPIES CORPORATION

Application No.: 10/557188   Filing Date: 25/May/2004

Abstract:The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or inhibitor identification, design and production, as well as screening assays for detection of same. The invention further relates to inhibitors identified by the assays according to the present invention.

Priority: FI20030000786 Applic. Date: 2003-05-26; FI20040000271 Applic. Date: 2004-02-20; WO2004FI00318 Applic. Date: 2004-05-25

Inventor: SALMINEN TIINA [FI]; AIRENNE TOMI [FI]; JOHNSON MARK [FI]; KIDRON HEIDI [FI]; NYMALM-REJSTROM YVONNE [FI]; SODERHOLM ANNU [FI]; SMITH DAVID [FI]; PIHLAVISTO MARJO [FI]; VIITANEN LENITA [FI]; PENTIKAINEN OLLI [FI]; NYRONEN TOMMI [FI]


Application No.: US20070093788A1  Published: 26/Apr/2007

Title: Iontophoresis method and apparatus for systemic delivery of active agents

Applicant/Assignee:

Application No.: 11/540504   Filing Date: 29/Sep/2006

Abstract:A method and an iontophoretic device are provided for delivery of one or more active agents via a circulatory system of a subject to a site of pain in the subject. In certain aspects, systemic delivery of active agents may alleviate pain at a site in a subject. Active agents may be selected from -caine-type anesthetics or painkillers. The device for delivery of an active agent may include a control unit.

Priority: US20050722136P Applic. Date: 2005-09-30; US20060839747P Applic. Date: 2006-08-24

Inventor: CARTER DARRICK [US]


Application No.: US20070098647A1  Published: 03/May/2007

Title: SKIN CARE PRODUCTS

Applicant/Assignee: NEUBOURG SKIN CARE GMBH & CO. KG

Application No.: 11/535526   Filing Date: 27/Sep/2006

Abstract:The invention relates to a formulation comprising an aqueous emulsion and a propellant gas for a foam skin cream, wherein the emulsion comprises urea and hyaluronic acid, at least one free fatty acid and at least two emulsifiers, wherein the hyaluronic acid has a molecular weight of at least 1x10<5 >Da.

Priority: US20050721170P Applic. Date: 2005-09-28; US20060785391P Applic. Date: 2006-03-23; DE200520015309U Applic. Date: 2005-09-28; DE200620004676U Applic. Date: 2006-03-23

Inventor: NEUBOURG THOMAS [DE]


Application No.: US20070098658A1  Published: 03/May/2007

Title: Cosmetic composition textured with a bis-urea derivative with a liquid fatty phase textured with a bis-urea compound

Applicant/Assignee: L'OREAL

Application No.: 11/585237   Filing Date: 24/Oct/2006

Abstract:A cosmetic composition textured with a bis-urea derivative with a liquid fatty phase textured with a bis-urea compound includes, in a physiologically acceptable medium, at least one liquid fatty acid phase, textured with at least one compound of general formula (I): in which A is a phenylene radical.

Priority: FR20050053231 Applic. Date: 2005-10-24; US20050752373P Applic. Date: 2005-12-22

Inventor: CHODOROWSKI-KIMMES SANDRINE [FR]; LIVOREIL AUDE [FR]; BAGHDADLI NAWEL [FR]; RODRIGUEZ IVAN [FR]


Application No.: US20070098664A1  Published: 03/May/2007

Title: Cosmetic application of rod-coil copolymers

Applicant/Assignee:

Application No.: 10/582668   Filing Date: 10/Dec/2004

Abstract:The present invention relates to a cosmetic composition containing, in a physiologically acceptable medium, at least one rod-coil type block copolymer comprising at least one "coil" polymeric block structure of variable conformation bonded to at least one "rod" block structure of restricted conformation, the composition being characterized in that said rod block structure is of polymeric nature and is constituted in full or in part of peptide motifs or the like with some or all of the free hydrogen atoms of said peptide motifs participating in non-covalent hydrogen bonds within the rod structure.

Priority: FR20030051028 Applic. Date: 2003-12-11; US20040534999P Applic. Date: 2004-01-09; WO2004FR50679 Applic. Date: 2004-12-10

Inventor: MOUGIN NATHALIE [FR]; SCHULTZE XAVIER [FR]


Application No.: US20070098755A1  Published: 03/May/2007

Title: Tissue augmentation devices and methods

Applicant/Assignee: COOK BIOTECH INCORPORATED

Application No.: 11/481422   Filing Date: 05/Jul/2006

Abstract:Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

Priority: US20050696606P Applic. Date: 2005-07-05

Inventor: PATEL UMESH H [US]; OBERMILLER F J [US]; SHAH BHAVIN [US]; JOHNSON CHAD E [US]


Application No.: US20070098805A1  Published: 03/May/2007

Title: Methods of making and using novel griseofulvin compositions

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LIMITED

Application No.: 11/546378   Filing Date: 12/Oct/2006

Abstract:The present invention is directed to nanoparticulate compositions comprising griseofulvin. The griseofulvin particles of the composition preferably have an effective average particle size of less than about 2 microns.

Priority: US2003-683154 Applic. Date: 2003-10-14; US2002-175851 Applic. Date: 2002-06-21; US1997-815346 Applic. Date: 1997-03-11

Inventor: LIVERSIDGE GARY G [US]


Application No.: US20070098820A1  Published: 03/May/2007

Title: Compositions containing cis-isomers of a carotenoid compound and process

Applicant/Assignee: NESTEC S.A

Application No.: 10/597851   Filing Date: 08/Feb/2005

Abstract:The present invention relates to a primary composition that includes at least one carotenoid-containing extract, concentrate or oleoresin enriched in cis-isomers of the carotenoid compound, and process of forming the same. It also relates to an oral composition that contains the primary composition in a foodstuff, in a food supplement, in a cosmetic preparation or in a pharmaceutical preparation.

Priority: EP20040002853 Applic. Date: 2004-02-10; EP20040015865 Applic. Date: 2004-07-06; WO2005EP01265 Applic. Date: 2005-02-08

Inventor: BORTLIK KARLHEINZ [CH]; RICHELLE MYRIAM [CH]; LAMBELET PIERRE [CH]; SAUCY FRANCOISE [CH]


Application No.: US20070099842A1  Published: 03/May/2007

Title: Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure

Applicant/Assignee:

Application No.: 10/555994   Filing Date: 07/May/2004

Abstract:The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R<1 >represents H, -C(O)-R<6>, -SO2-R<6 >or -C(O)-XR<6>

R<2 >and R<4>, independent of one another, represent (CH2)n-NH2 or (CH2)3-NHC(NH)NH2

n equals 1 4

R<3 >represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy

R<5 >and R<6>, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl

X represents oxygen (-O-) or -NH-

or XR<5 >with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R<1 >and R<5 >do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Priority: CH20030000807 Applic. Date: 2003-05-08; WO2004CH00278 Applic. Date: 2004-05-07

Inventor: ZIEGLER HUGO [CH]; HELDI MARC [DE]; IMFELD DOMINIK [CH]


Application No.: US20070099868A1  Published: 03/May/2007

Title: Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders

Applicant/Assignee: VASCULAR BIOGENICS LTD

Application No.: 11/528657   Filing Date: 28/Sep/2006

Abstract:Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

Priority: US2004-567543 Applic. Date: 2004-05-27; WO2004IL00453 Applic. Date: 2004-05-27; US2003-445347 Applic. Date: 2003-05-27

Inventor: HARATS DROR [IL]; GEORGE JACOB [IL]; HALPERIN GIDEON [IL]; MENDEL ITZHAK [IL]


Application No.: US20070099892A1  Published: 03/May/2007

Title: Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging

Applicant/Assignee:

Application No.: 11/432034   Filing Date: 10/May/2006

Abstract:Provided, among other things, is a compound of the formula:

Priority: US2003-645011 Applic. Date: 2003-08-21; US2001-905035 Applic. Date: 2001-07-13; US20000218273P Applic. Date: 2000-07-13; US20010296435P Applic. Date: 2001-06-06; US20010259242P Applic. Date: 2001-01-02; US20000259431P Applic. Date: 2000-12-29

Inventor: WAGLE DILIP R [IN]; FANG SHENG D [US]


Application No.: US20070100255A1  Published: 03/May/2007

Title: Method and apparatus for body fluid sampling and analyte sensing

Applicant/Assignee: PELIKAN TECHNOLOGIES, INC

Application No.: 10/558976   Filing Date: 28/May/2004

Abstract:A body fluid sampling system is provided for use on a tissue site. In one embodiment, the system comprises a cartridge

a penetrating member driver

a plurality of penetrating members arranged in a radial configuration on the cartridge wherein sharpened distal tips of the penetrating members point radially outward

wherein an active one of the penetrating members may be operatively coupled to the penetrating member driver, the penetrating member driver moving the active one along a path out of a housing having a penetrating member exit, into the tissue site, stopping in the tissue site, and withdrawing out of the tissue site

and a plurality of analyte detecting members, wherein at least one of the analyte detecting members is positioned to receive fluid from a wound created by the active one of the penetrating members, wherein the detecting members are not pierced by the active one of the penetrating members.

Priority: US2003-452815 Applic. Date: 2003-05-30; US2003-613517 Applic. Date: 2003-07-03; US2003-425815 Applic. Date: 2003-04-29; US2002-323622 Applic. Date: 2002-12-18; US2002-127395 Applic. Date: 2002-04-19; US2002-237261 Applic. Date: 2002-09-05; US2003-420535 Applic. Date: 2003-04-21; US2002-335142 Applic. Date: 2002-12-31; US2003-423851 Applic. Date: 2003-04-24; US20020422988P Applic. Date: 2002-11-01; US20020424429P Applic. Date: 2002-11-06; US20020428084P Applic. Date: 2002-11-20; US20030474915P Applic. Date: 2003-05-30; WO2004US17063 Applic. Date: 2004-05-28

Inventor: BOECKER DIRK [US]; FREEMAN DOMINIQUE M [US]; ALDEN DON [US]; SCHUMANN MATT [GB]; BEADMAN MICHAEL [GB]


Application No.: US20070104665A1  Published: 10/May/2007

Title: SURFACTANT-FREE DISPERSIONS, COMPOSITIONS, AND USE IN TOPICAL FORMULATIONS

Applicant/Assignee: DFB PHARMACEUTICALS, INC

Application No.: 11/548537   Filing Date: 11/Oct/2006

Abstract:The present invention provides for the preparation of stable surfactant-free dispersions of hydrophobic substances in low viscosity hydrophilic glyceryl polyacrylate or glyceryl polymethacrylate fluids, and topical vehicles formulated with the dispersions.

Priority: US20050725373P Applic. Date: 2005-10-11

Inventor: JONES DAVID P [US]; AUST DUNCAN T [US]; KULKARNI VITTHAL [US]


Application No.: US20070104728A1  Published: 10/May/2007

Title: Synergistic phytoceutical compositions

Applicant/Assignee:

Application No.: 11/271940   Filing Date: 10/Nov/2005

Abstract:Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.

Priority:

Inventor: OLALDE RANGEL JOSE A [VE]


Application No.: US20070104768A1  Published: 10/May/2007

Title: Devices for the delivery of molecular sieve materials for the formation of blood clots

Applicant/Assignee: Z-MEDICA CORPORATION

Application No.: 11/586968   Filing Date: 25/Oct/2006

Abstract:An apparatus for promoting the clotting of blood comprises a substrate and a zeolite in powder form deposited on the substrate. At least a portion of the substrate is selected from a group consisting of paper, polymer matrix, polyethylene sheet, hydrophilic macromolecules, and cloth. An agent for promoting the clotting of blood comprises a porous web structure and a compound capable of providing hemostasis incorporated into the porous web structure. The compound capable of providing hemostasis comprises at least one cationic species interspersed throughout and coulombically bound to the web structure such that the cationic species provides a positive charge to the web structure. A method of fabricating a blood clotting apparatus comprises the steps of providing a cellulose-based substrate

providing a zeolite

incorporating at least one cationic species into a structure of the zeolite to impart a positive charge thereto

and impregnating the cellulose-based substrate with the zeolite.

Priority: US20050734392P Applic. Date: 2005-11-07

Inventor: HUEY RAYMOND [US]; HORN JEFFREY L [US]


Application No.: US20070104799A1  Published: 10/May/2007

Title: Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds

Applicant/Assignee: SHIRE INTERNATIONAL LICENSING B.V

Application No.: 11/272563   Filing Date: 09/Nov/2005

Abstract:A subject with symptoms of chronic kidney disease (CKD), who does not have end-stage renal disease (ESRD), can be treated by orally administering a pharmaceutical composition as an active ingredient a therapeutically effective amount of a non-toxic lanthanum compound. Administration of a lanthanum compound can prevent the progression of CKD, treat soft tissue calcification, and treat secondary hyperparathyroidism.

Priority:

Inventor: PRATT RAYMOND D [US]; WEBSTER ISOBEL [GB]; DAMMENT STEPHEN J [GB]


Application No.: US20070105977A1  Published: 10/May/2007

Title: Kneadable Hand Putty as a Delivery System for Skin Conditioning and/or Thermal Therapy Agents

Applicant/Assignee:

Application No.: 11/558877   Filing Date: 10/Nov/2006

Abstract:A kneadable putty-like material that is used as a delivery system to deliver skin conditioning agents, and/or essential oils, and/or medicinal agents, and/or antimicrobial agents, and/or thermal therapy agents to the surface of the skin, in particular to the hands, in appropriate concentrations, is disclosed.

Priority: US20060747358P Applic. Date: 2006-05-16; US20050735297P Applic. Date: 2005-11-10

Inventor: GABRIEL GREGORY B [US]; FORD DON R [US]; HADDEN DAVID M [US]


Application No.: US20070106213A1  Published: 10/May/2007

Title: GASTROINTESTINAL APPLICATOR AND METHOD OF USING SAME

Applicant/Assignee:

Application No.: 11/553546   Filing Date: 27/Oct/2006

Abstract:A method and apparatus for dispensing a relatively viscous composition to a wound site at a location within a mammalian body requiring a relatively long and thin catheter for access includes filling a distal tip of the catheter with the composition, directing the distal tip to the wound site, dispensing the composition onto the wound site and then inflating a balloon against the applied composition to enable same to congeal enough so that the composition remains fixed to the wound site after the catheter is removed from the body. In an embodiment the balloon is secured to the catheter such that when air is applied through the catheter to the balloon, the balloon expands longitudinally and distally past a distal end of the catheter.

Priority: US20050731350P Applic. Date: 2005-10-28

Inventor: SPERA GIANLUCA [IT]; ARIAGNO SCOTT R [US]


Application No.: US20070110696A1  Published: 17/May/2007

Title: Shampoo containing a gel network and a non-guar galactomannan polymer derivative

Applicant/Assignee:

Application No.: 11/602525   Filing Date: 21/Nov/2006

Abstract:Shampoo compositions comprise (a) from about 5% to about 50% of one or more detersive surfactants

(b) a dispersed gel network phase comprising: (i) at least about 0.05% of one or more fatty amphiphiles

(ii) at least about 0.01% of one or more secondary surfactants

and (iii) water

(c) at least about 0.05% of a galactomannan polymer derivative with a net positive charge and having a mannose to galactose ratio of greater than 2:1 on a monomer to monomer basis, wherein the galactomannan polymer derivative has: (i) a molecular weight from about 1,000 to about 10,000,000

and (ii) a cationic charge density from about 0.7 meq/g to about 7 meq/g

and (d) at least about 20% of an aqueous carrier

all by weight of the shampoo composition.

Priority: US2006-475485 Applic. Date: 2006-06-27; US2005-228770 Applic. Date: 2005-09-16; US2003-454433 Applic. Date: 2003-06-04; US20020385641P Applic. Date: 2002-06-04

Inventor: JOHNSON ERIC S [US]; HILVERT JENNIFER E [US]; HEATH BENJAMIN P [US]; COOPER SARAH E [US]


Application No.: US20070110700A1  Published: 17/May/2007

Title: Shampoo containing a gel network

Applicant/Assignee:

Application No.: 11/602705   Filing Date: 21/Nov/2006

Abstract:Shampoo compositions comprise (a) from about 5% to about 50% of one or more detersive surfactants, by weight of the shampoo composition

(b) a dispersed gel network phase comprising, by weight of the shampoo composition, (i) at least about 0.05% of one or more fatty amphiphiles

(ii) at least about 0.01% of one or more secondary surfactants

and (iii) water

and (c) at least about 20% of an aqueous carrier, by weight of the shampoo composition. A process for preparing a shampoo composition comprises the steps of: (a) combining a fatty amphiphile, a secondary surfactant, and water at a temperature sufficient to allow partitioning of the secondary surfactant and the water into the fatty amphiphile to form a pre-mix

(b) cooling the pre-mix below the chain melt temperature of the fatty amphiphile to form a gel network

(c) adding the gel network to one or more detersive surfactants and an aqueous carrier to form a shampoo composition.

Priority: US2005-228770 Applic. Date: 2005-09-16; US2003-454433 Applic. Date: 2003-06-04; US20020385641P Applic. Date: 2002-06-04

Inventor: WELLS ROBERT L [US]; ROYCE DOUGLAS A [US]; JOHNSON ERIC S [US]; ELSNER ELIZABETH MARIE M [US]; HILVERT JENNIFER E [US]; JIN YINGKUN [US]; HURLEY BRIAN M [US]; MANUEL TERESA C [US]; HEATH BENJAMIN P [US]


Application No.: US20070110704A1  Published: 17/May/2007

Title: Combination of 2,3-dibenzylbutyrolactone and licochalcone-a

Applicant/Assignee:

Application No.: 10/581271   Filing Date: 22/Nov/2004

Abstract:Active ingredient combinations of (a) one or more 2,3-dibenzylbutyrolactone derivatives and (b) licochalcone A or an aqueous extract of Radix Glycyrrhizae inflatae containing licochalcone A.

Priority: DE20031057451 Applic. Date: 2003-12-03; WO2004EP13254 Applic. Date: 2004-11-22

Inventor: GALLINAT STEFAN [DE]; KOLBE LUDGER [DE]; MUMMERT CHRISTOPHER [DE]; WOLBER RAINER [DE]; STAEB FRANZ [DE]


Application No.: US20070110731A1  Published: 17/May/2007

Title: Integument Cell Regeneration Formulation

Applicant/Assignee:

Application No.: 11/560567   Filing Date: 16/Nov/2006

Abstract:The invention relates to a composition-of-matter and method of using a topical composition having 10-99 999% by weight of a topical base formulation and other active ingredients including stem cell or growth factors and/or antioxidants, as well as others for the purpose of regenerating integument cells

Priority: US20050597204P Applic. Date: 2005-11-16

Inventor: RILEY PATRICIA A [US]


Application No.: US20070110753A1  Published: 17/May/2007

Title: Therapeutic agents for solid tumors

Applicant/Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA

Application No.: 10/574860   Filing Date: 07/Oct/2004

Abstract:A therapeutic agent for solid tumors, said agent comprising as an active ingredient, an antibody that specifically binds to a protein having the amino acid sequence as set forth in SEQ ID NO: 2 or an antibody fragment that maintains the antibody activity.

Priority: JP20030352819 Applic. Date: 2003-10-10; WO2004JP15205 Applic. Date: 2004-10-07

Inventor: KAWAI SHIGETO [JP]; MIHARA MASAHIKO [JP]; KOISHIHARA YASUO [JP]


Application No.: US20070110792A1  Published: 20/Jul/2006

Title: Cosmetic or dermatological article comprising a medium that is soluble in water

Applicant/Assignee: L'OREAL

Application No.: 11/303961   Filing Date: 27/Mar/2006

Abstract:A cosmetic or dermatological article may include: a medium in the form of at least one sheet of a material that is soluble in water at a temperature lower than 20 DEG C.

and at least one cosmetic or dermatological compound carried by the medium.

Priority: FR20050050014 Applic. Date: 2005-01-03; US20050658165P Applic. Date: 2005-03-04

Inventor: SIMON PASCAL [FR]


Application No.: US20070110808A1  Published: 17/May/2007

Title: Extended release osmo-microsealed formulation

Applicant/Assignee: ALEMBIC LIMITED

Application No.: 10/563631   Filing Date: 14/May/2004

Abstract:The extended release osmo-microsealed formulation includes three controlled release systems associated in series. First, there is an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle. Second, there is an outer solid continuous phase including one or more hydrophilic polymers, that is further compressed into a tablet. Third, there is an optional functional coat surrounding the tablet. The process/method for forming the Osmo-microsealed extended release delivery system and the process for using such system for treating human ailment/depression are also provided.

Priority: IN2003MU00504 Applic. Date: 2003-06-05; WO2004IN00133 Applic. Date: 2004-05-14

Inventor: BHATTACHARYA SAMPAD [IN]; GUMMUDAVELLI SRIDHAR [IN]; JOSHI MAYANK [IN]; EGBERT JOHN S [US]


Application No.: US20070110817A1  Published: 17/May/2007

Title: Biological active blood serum obtained by electrostimulation

Applicant/Assignee: OWEN HOLDING LTD

Application No.: 10/581420   Filing Date: 20/Dec/2004

Abstract:The present invention relates to a method for preparing a blood serum product, the blood serum product and a pharmaceutical composition comprising said blood serum product as well as uses thereof in the treatment of various diseases and conditions, including epileptic seizures and apoplexy.

Priority: US20040619738P Applic. Date: 2004-10-18; WO2004EP14510 Applic. Date: 2004-12-20

Inventor: SHESTAKOV VITALI A [RU]


Application No.: US20070110818A1  Published: 17/May/2007

Title: Milk fractions and milk preparations for treating and/or preventing cox-2 mediated diseases

Applicant/Assignee:

Application No.: 10/571959   Filing Date: 13/Sep/2004

Abstract:The present invention pertains to nutritional and pharmaceutical compositions for treating and preventing cyclooxygenase-2 mediated diseases and to a process for increasing the cyclooxygenase-2 inhibiting activity of a product. In addition thereto, the present invention relates to the use of one ore more milk protein fractions and/or one ore more milk protein preparations for inhibiting the activity of cyclooxygenase-2 (COX-2), in particular for the preparation of a medicament or a functional food for treating and preventing cyclooxygenase-2 mediated diseases.

Priority: EP20030020739 Applic. Date: 2003-09-12; WO2004EP10200 Applic. Date: 2004-09-13

Inventor: BOVETTO LIONEL [FR]; HAU JOERG [CH]; MACE CATHERINE [CH]


Application No.: US20070110934A1  Published: 17/May/2007

Title: Container closure with a multi-layer oxygen barrier liner

Applicant/Assignee: ALCOA CLOSURE SYSTEMS INTERNATIONAL, INC

Application No.: 11/653678   Filing Date: 16/Jan/2007

Abstract:A container closure with a multiple layer liner. The liner comprises a nylon gas transmission barrier and a non-nylon layer bonded by an adhesive layer. The nylon gas transmission barrier may contain an additional passive gas transmission component comprising an in-situ polymerized inorganic clay. An additional active gas transmission component comprising a chemically reactive scavenger may be incorporated into at least one layer of the multiple layer liner. Materials of the liner are selected for their process conditions and resulting resistance to degradation.

Priority: US2002-282583 Applic. Date: 2002-10-29

Inventor: GOLDMAN ANATOLIY [US]


Application No.: US20070111306A1  Published: 17/May/2007

Title: SYSTEMS AND METHODS FOR SELECTION AND MAINTENANCE OF HOMOGENEOUS AND PLURIPOTENT HUMAN EMBRYONIC CELLS

Applicant/Assignee: THE PENN STATE RESEARCH FOUNDATION

Application No.: 11/557791   Filing Date: 08/Nov/2006

Abstract:A number of human disorders are characterized by degeneration or loss of specific cells, resulting in pathology associated with reduction or absence of cell function. Such diseases include neurodegenerative diseases and diabetes. Methods are described for obtaining a substantially homogeneous population of undifferentiated human embryonic stem cells including incubating a population of human embryonic stem cells with an amount of a selection agent. The selection agent is effective to reduce or eliminate differentiated embryonic stem cells from the population of cells such that a substantially homogeneous population of undifferentiated human embryonic stem cells is obtained. The substantially homogeneous population of undifferentiated embryonic stem cells may be produced without use of feeder cells.

Priority: US20050734862P Applic. Date: 2005-11-09

Inventor: SALLI UGAR [US]; KESTER MARK [US]; VRANA KENT E [US]


Application No.: US20070111915A1  Published: 17/May/2007

Title: Antimicrobial compositions comprising polymeric stabilizers

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 10/581007   Filing Date: 01/Dec/2004

Abstract:Antimicrobial composition comprising iodide and thiocyanate anions, periodic acid, and nitrogen and/or phosphorous containing polymers.

Priority: GB20030028156 Applic. Date: 2003-12-04; WO2004EP13606 Applic. Date: 2004-12-01

Inventor: ASHWORTH DAIVD W [GB]; HODGKINSON DARREN [GB]; HUFF JURGEN [DE]


Application No.: US20070112042A1  Published: 17/May/2007

Title: Topical agent for application to the skin prior to luminous treatment

Applicant/Assignee:

Application No.: 11/652611   Filing Date: 12/Jan/2007

Abstract:There is disclosed a topical agent in the form of a topical vasodilator for the application to the skin prior to luminous treatment, e.g. laser treatment, wherein said topical vasodilator in a suitable vehicle includes the active substance consisting of nicotinic acid (Niacin) in the range of 0.5-10.0% by weight Preferably, the topical vasodilator is a skin cream containing the active substance, Niacin, in the range of 5% by weight.

Priority: US2003-401957 Applic. Date: 2003-03-31

Inventor: CHRISTENSEN FLEMMING K [DK]


Application No.: US20070116660A1  Published: 24/May/2007

Title: Copolymers based on tertbutyl(meth) acrylate and use thereof

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 10/581884   Filing Date: 08/Dec/2004

Abstract:Copolymers which contain tert-butyl (meth)acrylate, at least one alpha,beta-ethylenically unsaturated amido-containing compound and acrylic acid incorporated in the form of polymerized units, cosmetic and pharmaceutical compositions which contain at least one such copolymer and the use of these copolymers are described.

Priority: DE20031057486 Applic. Date: 2003-12-09; WO2004EP13984 Applic. Date: 2004-12-08

Inventor: KIM SON N [DE]; WOOD CLAUDIA [DE]


Application No.: US20070116662A1  Published: 24/May/2007

Title: Antiperspirant/deodorant compositions

Applicant/Assignee:

Application No.: 11/284274   Filing Date: 21/Nov/2005

Abstract:Disclosed herein is a composition for topical. application to human skin, comprising a biologically active material and a cosmetically suitable carrier, wherein the cosmetically suitable carrier comprises 5-95 wt % of a mixed feed polyolefin based on the total weight of the composition, wherein the mixed feed polyolefin comprises two or more C6-C20 copolymerized monomers, and wherein at least two of the copolymerized monomers are each present in the mixed feed polyolefin at 10 wt % or more, based on the total weight of the mixed feed polyolefin. A method of making a composition for topical application to human skin is also disclosed.

Priority:

Inventor: ZIELINSKI JAMES [US]; OEHLER PETER C [US]; COOPER KATHLEEN K [US]


Application No.: US20070116691A1  Published: 24/May/2007

Title: Conditionally immortalized long-term stem cells and methods of making and using such cells

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO

Application No.: 11/583970   Filing Date: 18/Oct/2006

Abstract:Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Priority: US20050728131P Applic. Date: 2005-10-18; US20060765993P Applic. Date: 2006-02-06

Inventor: CAMBIER JOHN C [US]; REFAELI YOSEF [US]; JOHNSON SARA A [US]; TURNER BRIAN C [US]


Application No.: US20070116731A1  Published: 24/May/2007

Title: Dermatological cream-gels containing avermectin compounds

Applicant/Assignee: GALDERMA S.A

Application No.: 11/522312   Filing Date: 18/Sep/2006

Abstract:Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30 DEG C. and being free of solid fats having a melting point above 30 DEG C., formulated into a physiologically acceptable medium therefor.

Priority: FR20040002798 Applic. Date: 2004-03-18; WO2005EP03718 Applic. Date: 2005-03-17; US20040556028P Applic. Date: 2004-03-25

Inventor: ASTRUC FANNY [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]


Application No.: US20070116751A1  Published: 24/May/2007

Title: Medical active substance patch with reduced optical conspicuousness on the skin

Applicant/Assignee:

Application No.: 10/553708   Filing Date: 08/Apr/2004

Abstract:A medical active substance patch comprising a matrix of monolayer or multilayer configuration with at least one active substance-containing layer and comprising a backing layer connected with the matrix. The active substance patch is transparent or at least translucent, and in the state of having been applied to the skin of a first person, the patch has a lightness colour value L1 at a place of the skin covered by the patch which is not less than 50% and not more than 200% of a lightness colour value L2, L2 being the lightness value of the region of the skin of the same person which surrounds the applied patch. The same is true of the skin of a second or any other person, provided that for all the persons mentioned L2 is in the range from 5 DEG to 100 DEG , namely from 20 DEG to 90 DEG .

Priority: DE20031017692 Applic. Date: 2003-04-17; WO2004EP03748 Applic. Date: 2004-04-08

Inventor: BRACHT STEFAN [DE]


Application No.: US20070116779A1  Published: 24/May/2007

Title: Comprehensive nutraceutical agent for treatment/ prevention of Parkinson's disease

Applicant/Assignee:

Application No.: 11/438746   Filing Date: 22/May/2006

Abstract:This invention discloses a comprehensive nutraceutical designed to antagonize major mitigating factors specific to the degenerative process that occurs in Parkinson's disease (PD). The formulation is comprised of pyruvate, succinate and/or oxaloacetate further combined with specific macro/micronutrients, trace elements, amino acids, flavonoids and concentrated plant sources. The formula is based on means to attenuate the loss of ATP/toxicity by PD model toxins: 1-methyl-4-phenylpyridinium and rotenone, scavenge hydrogen peroxide/O2, augment antioxidant enzymes, prevent dopamine oxidation to DA-quinone via inhibition of COX, PLA2, LOX, xanthine oxidase, tyrosinase, prevent hyperhomocysteinemia, antagonize PARP-1 apoptosis, increase blood flow, glucose and oxygen delivery to the brain, potentiate mitochondrial function, antagonize glia iNOS and MAO or its products, chelate redox-active iron, inhibit hemeoxygenase-1, inhibit alpha-synuclein aggregation, augment ATP storage, mediate anti-inflammatory effects via inhibition. of PDE, MAPK p38/c-Jun NH2-terminal kinase/PGE2, antagonize excitotoxicity and downregulate N-methyltransferase, all of which contribute toward PD pathology.

Priority: US20050739980P Applic. Date: 2005-11-23

Inventor: MAZZIO ELIZABETH [US]


Application No.: US20070117133A1  Published: 24/May/2007

Title: Sparc and methods of use thereof

Applicant/Assignee: ABRAXIS BIOSCIENCE, INC

Application No.: 11/599100   Filing Date: 14/Nov/2006

Abstract:The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.

Priority: WO2005US17174 Applic. Date: 2005-05-16; US20060788208P Applic. Date: 2006-03-31; US20040571622P Applic. Date: 2004-05-14; US20050654261P Applic. Date: 2005-02-18

Inventor: TRIEU VUONG [US]; DESAI NEIL P [US]; SOON-SHIONG PATRICK [US]


Application No.: US20070117157A1  Published: 24/May/2007

Title: Parathyroid hormone-like polypeptides

Applicant/Assignee:

Application No.: 10/490319   Filing Date: 15/Sep/2003

Abstract:Novel parathyroid hormone polypeptides and biologically active fragments thereof are disclosed along with nucleic acid molecules encoding same. In particular, parathyroid hormone polypeptides and biologically active fragments (and encoding nucleic acid molecules) derived from fish species (eg Japanese pufferfish (Fugu rubripes)) are disclosed. Such polypeptides and fragments may be used for treatment of diseases associated with abnormal calcium homeostasis (eg osteoporosis, osteopenia, Paget's disease, bone cancer, hyperparathyroidism, hypoparathyroidism, hypercalcemia, psoriasis and other skin-related conditions).

Priority: AU20020951372 Applic. Date: 2002-09-13; WO2003AU01201 Applic. Date: 2003-09-15

Inventor: ZAJAC JEFFREY D [AU]


Application No.: US20070117208A1  Published: 24/May/2007

Title: Radiation exposure history indicator

Applicant/Assignee: NICHIYU GIKEN KOGYO CO., LTD

Application No.: 10/578368   Filing Date: 05/Nov/2004

Abstract:A radiation exposure history indicator sheet comprises a base material sheet which has a color-changing layer on at least a part of the surface comprising: a polymer compound having a hydroxyl group and at least one group selected from a halogen group and an acetal group

a coloring organic electron donor compound

an active species-generating organic compound for making the organic electron donor compound colored by a radiation

and a radiation absorbent and/or a radiation-excite fluorescent agent.

Priority: JP20030376755 Applic. Date: 2003-11-06; JP20040165608 Applic. Date: 2004-06-03; JP20040264979 Applic. Date: 2004-09-13; WO2004JP16784 Applic. Date: 2004-11-05

Inventor: NIWA YUKIYO [JP]


Application No.: US20070117816A1  Published: 24/May/2007

Title: KINASE INHIBITORS

Applicant/Assignee:

Application No.: 11/539857   Filing Date: 09/Oct/2006

Abstract:Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Priority: US20050724619P Applic. Date: 2005-10-07

Inventor: BROWN JASON W [US]; DAS SANJIB [US]; DONG QING [US]; GONG XIANCHANG [US]; KALDOR STEPHEN W [US]; LIU YAN [US]; PARASELLI BHEEMA R [US]; SCORAH NICHOLAS [US]; STAFFORD JEFFREY A [US]; WALLACE MICHAEL B [US]


Application No.: US20070118405A1  Published: 24/May/2007

Title: User Interface For Infusion Pump Remote Controller And Method Of Using The Same

Applicant/Assignee: INSULET CORPORATION

Application No.: 11/616945   Filing Date: 28/Dec/2006

Abstract:A control system for controlling an infusion pump, including interface components for allowing a user to receive and provide information, a processor connected to the user interface components and adapted to provide instructions to the infusion pump, and a computer program having setup instructions that cause the processor to enter a setup mode upon the control system first being turned on. In the setup mode, the processor prompts the user, in a sequential manner, through the user interface components to input basic information for use by the processor in controlling the infusion pump, and allows the user to operate the infusion pump only after the user has completed the setup mode.

Priority: US2004-827582 Applic. Date: 2004-04-19; US20030463809P Applic. Date: 2003-04-18

Inventor: CAMPBELL ROBERT [US]; GEMMELL STEPHEN [US]; VOGT MARC [US]; GARIBOTTO JOHN T [US]; MALAVE LUIS [US]; CATE-BROWN DEBORAH [US]; OPPENHEIMER AARON [US]; VIVONA CHRISTINA [US]; MANDLER PAMELA [US]; FREY DAVID [US]


Application No.: US20070122463A1  Published: 31/May/2007

Title: ANTIMICROBIAL COMPOSITIONS AND WOUND DRESSINGS

Applicant/Assignee: FENG CHIA UNIVERSITY

Application No.: 11/562284   Filing Date: 21/Nov/2006

Abstract:A wound dressing and an antimicrobial composition are provided. The wound dressing comprises a carbonaceous material, a noble metal carried on the carbonaceous material, and, optionally, a flexible base layer, wherein the carbonaceous material is selected from a group consisting of activated carbon, graphite, carbon, and a combination thereof, while the noble metal is selected from a group consisting of Ag, Au, Pd, Pt, Cu, Zn, and a mixture thereof. The antimicrobial composition is for topical use on skins and comprises the aforementioned carbonaceous material as well as the noble metal carried on the carbonaceous material.

Priority: TW20050141437 Applic. Date: 2005-11-25; TW20060134585 Applic. Date: 2006-09-19

Inventor: KO TSE-HAO [TW]


Application No.: US20070122496A1  Published: 31/May/2007

Title: Herbal composition for treatment of immunocompromised conditions

Applicant/Assignee: SAHAJANAND BIOTECH PVT. LTD

Application No.: 11/287853   Filing Date: 28/Nov/2005

Abstract:According to the present invention there is provided pharmaceutical or medicinal preparation comprising a combination of two herbal compositions to be administered together. The first herbal composition comprises a mixture of the following herbs: Asparagus racemosa, Curcuma longa, Glycyrrhiza glabra, Momordica charantia, Tinospora cordifolia, Withania somnifera, Spirulina, Allium sativum, Emblica officinalis, Terminalia belerica, and Terminalia chebula, or a mixture of the active ingredients that have been extracted from those herbs or chemically synthesized.

The second herbal composition comprises a mixture of the following herbs: Moringa oleifera, Boerhavia diffusa, Onosma bracteatum, Bauhinia variegata, Spheranthus indicus, Tecomella undulata, Chlorophytum borivilianum, Ficus racemosa, and Cyperus rotundus, or a mixture of the active ingredients that have been extracted from those herbs or chemically synthesized. The herbal preparation is effective for the treatment a wide range of physiological and pathological conditions in the human body resulting from a weakened or deteriorating immune system.

Priority:

Inventor: MANAGOLI NANDKISHOR B [IN]


Application No.: US20070122500A1  Published: 31/May/2007

Title: Cosmetic compositions in particular with anti-ageing activity comprising an extract of aframomum angustifolium or longoza plant

Applicant/Assignee: LVMH RECHERCHE

Application No.: 11/543561   Filing Date: 04/Oct/2006

Abstract:The present invention relates to a cosmetic composition. This composition is characterized in that it comprises, as active ingredient, an extract of seeds of the Aframomum angustifolium or Longoza plant, optionally in a cosmetically acceptable excipient. This cosmetic composition exhibits a good anti-ageing activity.

Priority: FR20050010147 Applic. Date: 2005-10-04

Inventor: ANDRE PATRICE [FR]; RENIMEL ISABELLE [FR]; SAUVAN NANCY [FR]; RAZAFIMAMBIMBY HANITRINIAINA [MG]


Application No.: US20070122505A1  Published: 31/May/2007

Title: Natural antioxidant additive for feed and drinking water

Applicant/Assignee:

Application No.: 11/287602   Filing Date: 28/Nov/2005

Abstract:A natural intestine-functional additive with antioxidative properties for utilization as an additive in animal feed containing natural and/or nature identical active substances. The substance include a first active component containing antioxidative active substances derived from plant material from olive plants (Olea europaea L) and a second active component containing antioxidative active substances derived from plant material from grape plants (Vitis vinifera L).

Priority:

Inventor: ELGAARD TROELS [DK]; NIELSEN BEATRICE KONSTANZE K [DK]


Application No.: US20070122509A1  Published: 31/May/2007

Title: ANTIOXIDANT DIETARY SUPPLEMENT COMPOSITIONS AND METHODS FOR MAINTAINING HEALTHY SKIN

Applicant/Assignee: MOLECULAR RESEARCH CENTER, INC

Application No.: 11/559205   Filing Date: 13/Nov/2006

Abstract:Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene containing tomato compositions has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.

Priority: US2005-273514 Applic. Date: 2005-11-14; US20040632481P Applic. Date: 2004-12-02; US20050708498P Applic. Date: 2005-08-16

Inventor: CHOMCZYNSKI PIOTR [US]


Application No.: US20070123464A1  Published: 31/May/2007

Title: METHODS AND REAGENTS FOR TREATING INFLAMMATION AND FIBROSIS

Applicant/Assignee: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

Application No.: 11/613070   Filing Date: 19/Dec/2006

Abstract:Methods are provided for providing anti-inflammatory activity and inhibiting a fibrotic disease, such as pulmonary fibrosis, in an individual. The methods comprise administering a biologically effective amount of latency-associated peptide (LAP) to the individual. Also provided are pharmaceutical compositions comprising LAP for use in accordance with these methods.

Priority: US2004-892997 Applic. Date: 2004-07-16; US20030487826P Applic. Date: 2003-07-16

Inventor: MARSH CLAY B [US]; OROSZ CHARLES G [US]


Application No.: US20070128137A1  Published: 07/Jun/2007

Title: Water in oil emulsion compositions containing siloxane elastomers

Applicant/Assignee:

Application No.: 11/607220   Filing Date: 01/Dec/2006

Abstract:The present invention relates to water in oil emulsion compositions comprising: from about 0.1% to about 15% of a non-emulsifying crosslinked siloxane elastomer

from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer

from about 1% to about 40% of a solvent for the non-emulsifying and emulsifying crosslinked siloxane elastomers

optionally, from 0% to about 5% of an additional emulsifier

and from about 50% to about 99% of aqueous phase

wherein when shear stress is applied to the composition during spreading on skin, aqueous phase is released from the emulsion.

Priority: US20050742073P Applic. Date: 2005-12-02; US20060800554P Applic. Date: 2006-05-15; US20060812791P Applic. Date: 2006-06-12

Inventor: YOSHIMI NAOHISA [JP]; TANAKA HIDEKAZU [JP]; UEDA AKIHIRO [JP]; YAMADA KOSAKU [JP]; STUMP KARA J [US]; ZHU CHU [US]


Application No.: US20070128256A1  Published: 07/Jun/2007

Title: SOLUBLE COSMETIC ARTICLE WITH A THERMAL EFFECT

Applicant/Assignee: L'OREAL

Application No.: 11/567867   Filing Date: 07/Dec/2006

Abstract:An article having a support in the form of at least one sheet containing fibers that are water-soluble at a temperature of 0-30 DEG C., the support having a density less than or equal to 0.1 g/cm<3>, and a composition carried by the support, containing at least one compound with a thermal effect. The article can have a hot or cold effect depending on the nature of the compound(s) with thermal effect that is(are) present.

Priority: FR20050053750 Applic. Date: 2005-12-07; US20050752030P Applic. Date: 2005-12-21

Inventor: AUBRUN-SONNEVILLE ODILE [FR]


Application No.: US20070128263A1  Published: 07/Jun/2007

Title: TRANSDERMAL THERAPEUTIC SYSTEM

Applicant/Assignee:

Application No.: 11/539979   Filing Date: 10/Oct/2006

Abstract:The present invention relates to Transdermal Therapeutic Systems having a silicone adhesive layer, to Transdermal Therapeutic Systems providing specific plasma concentrations, to their manufacture and use.

Priority: US20050741511P Applic. Date: 2005-12-01

Inventor: GARGIULO PAUL M [US]; LANE ROGER M [US]; PLATT BEATRIX [DE]; THEOBALD FRANK [DE]; WALL BETTINA [DE]


Application No.: US20070128265A1  Published: 07/Jun/2007

Title: Regulation of cell proliferation and differentiation using topically applied peptides

Applicant/Assignee:

Application No.: 11/639238   Filing Date: 15/Dec/2006

Abstract:Methods are disclosed for the regulation of cell differentiation and proliferation, e.g., for treating hyperproliferative skin disorders, such as psoriasis, for enhancing wound healing, for stimulating hair growth and inhibiting hair growth, by topical administration of parathyroid hormone (PTH), parathyroid related peptide (PTHrP), or fragment, analog or derivative thereof, and salts thereof, encapsulated by liposomes.

Priority: US2003-311366 Applic. Date: 2003-05-28; WO2001US19650 Applic. Date: 2001-06-20; US20000213247P Applic. Date: 2000-06-22

Inventor: HOLICK MICHAEL F [US]


Application No.: US20070128302A1  Published: 07/Jun/2007

Title: Composition containing an extract of the fruit of schisandra chinensis and process for producing same

Applicant/Assignee: COGNIS FRANCE S.A

Application No.: 10/578344   Filing Date: 29/Oct/2004

Abstract:A composition including (a) an extract from the fruit of Schisandra chinensis

and (b) at least one auxiliary and/or additive is provided. A composition also provided includes (a) a component selected from the group of an extract of the fruit of Schisandra chinensis, schizandrin, deoxyschizandrin, schisandrin C, gomisin A, gomisin N, pregomisin, and nordihydroguaiaretic acid

and (b) at least one auxiliary and/or additive. A process for producing an extract from the fruit of Schisandra chinensis is also provided, and includes the steps of (a) extracting of the fruit of Schisandra chinensis with a solvent selected from the group consisting of water, alcohols, esters, hydrocarbons, ketones, halogenated hydrocarbons and supercritical fluids to obtain a mixture comprising the extract and the solvent

and, (b) removing the solvent from the mixture.

Priority: EP20030292802 Applic. Date: 2003-11-07; WO2004EP12278 Applic. Date: 2004-10-29

Inventor: HENRY FLORENCE [FR]; DANOUX LOUIS [FR]; PAULY GILLES [FR]


Application No.: US20070128599A1  Published: 07/Jun/2007

Title: Method for improved diagnosis of dysplasias

Applicant/Assignee:

Application No.: 10/533384   Filing Date: 21/Oct/2003

Abstract:The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Priority: EP20020024030 Applic. Date: 2002-10-28; EP20030100584 Applic. Date: 2003-03-07; WO2003EP50738 Applic. Date: 2003-10-21

Inventor: RIDDER RUEDIGER [DE]; REICHERT ANJA [DE]; TRUNK-GEHMACHER MARCUS [DE]; BATRLA RICHARD [DE]


Application No.: US20070129365A1  Published: 07/Jun/2007

Title: 6-Substituted pyridoindolone derivatives, production and therapeutic use thereof

Applicant/Assignee: SANOFI-AVENTIS

Application No.: 11/582769   Filing Date: 18/Oct/2006

Abstract:Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description

pharmaceutical compositions comprising said compounds

and processes for preparing said compounds and methods of use thereof.

Priority: FR20040004251 Applic. Date: 2004-04-21; WO2005FR00971 Applic. Date: 2005-04-20

Inventor: BOURRIE BERNARD [FR]; CASELLAS PIERRE [FR]; CIAPETTI PAOLA [FR]; DEROCO JEAN-MARIE [FR]; JEGHAM SAMIR [FR]; MUNEAUX YVETTE [FR]; WERMUTH CAMILLE-GEORGES [FR]


Application No.: US20070129378A1  Published: 07/Jun/2007

Title: Compounds for the treatment of inflammatory disorders and microbial diseases

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/605927   Filing Date: 29/Nov/2006

Abstract:This invention relates to compounds of the Formulae (I)-(IX): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-alpha or combinations thereof.

Priority: US20050741264P Applic. Date: 2005-12-01

Inventor: SIDDIQUI M A [US]; MANSOOR UMAR F [US]; REDDY PANDURANGA A P [US]; MADISON VINCENT S [US]


Application No.: US20070129428A1  Published: 07/Jun/2007

Title: Composition for improving skin, hair and coat health containing flavanones

Applicant/Assignee:

Application No.: 10/596468   Filing Date: 17/Dec/2004

Abstract:The present invention pertains to a composition for preventing, decreasing and/or treating skin and hair/coat disorders, such as is effected by inflammatory reactions, environmental factors, ageing or cancer. In particular, the present invention relates to the use of flavanones compounds or their derivatives in nutritional, cosmetic or pharmaceutical compositions for improvement of human or pet animal skin and coat conditions.

Priority: EP20030029183 Applic. Date: 2003-12-18; WO2004EP14416 Applic. Date: 2004-12-17

Inventor: RICHELLE MYRIAM [CH]; OFFORD-CAVIN ELIZABETH [CH]; BORTLIK KARLHEINZ [CH]; BUREAU-FRANZ ISABELLE [CH]; WILLIAMSON GARY [CH]; NIELSEN INGE L [CH]; STEILING HEIKE [CH]; MOODYCLIFFE ANGUS [CH]


Application No.: US20070129446A1  Published: 07/Jun/2007

Title: Use of fepradinol for the production of a pharmaceutical composition for the treatment of rosacea

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 10/580253   Filing Date: 10/Nov/2004

Abstract:The invention relates to the use of fepradinol for the production of novel pharmaceutical compositions, in particular, dermatological compositions, of use for the treatment of rosacea.

Priority: FR20030013664 Applic. Date: 2003-11-21; WO2004FR02900 Applic. Date: 2004-11-10

Inventor: DOLFI FABRIZIO [FR]; PILGRIM WILLIAM R [FR]


Application No.: US20070134172A1  Published: 14/Jun/2007

Title: Flavonoid derivative

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 10/581494   Filing Date: 05/Nov/2004

Abstract:The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.

Priority: DE20031057004 Applic. Date: 2003-12-05; WO2004EP12538 Applic. Date: 2004-11-05

Inventor: BUCHHOLZ HERWIG [DE]; WIRTH CORINNA [DE]; CAROLA CHRISTOPHE [DE]; ALVES FONTES ROSANE [BR]


Application No.: US20070134174A1  Published: 14/Jun/2007

Title: Personal care composition

Applicant/Assignee:

Application No.: 11/591239   Filing Date: 01/Nov/2006

Abstract:Personal care composition comprising from about 5% to about 75% of an oil phase

an aqueous phase

from about 0.1% to about 2% of a polymeric thickener

and a skin care active

wherein said composition comprises at least two separate phases, and after agitation and dispensation from a suitable container containing a suitable propellant, forms stable foam.

Priority: US20050733058P Applic. Date: 2005-11-03

Inventor: IRWIN CHRISTOPHER [US]; TANNER PAUL R [US]; ELSBROCK ROBERT J [US]; SZCZEPANIAK RICHARD J [US]


Application No.: US20070134175A1  Published: 14/Jun/2007

Title: Panthenol and natural organic extracts for reducing skin irritation

Applicant/Assignee:

Application No.: 11/702090   Filing Date: 05/Feb/2007

Abstract:Panthenol combined with natural organic extracts are well suited for reducing skin irritation that is normally elicited by exposure to irritant active agents or compounds, particularly found in hair permanent and relaxing compositions, hair colorants and depilatories.

Priority: US2004-014243 Applic. Date: 2004-12-17; US20030530655P Applic. Date: 2003-12-19

Inventor: BELLAMY DAVID [US]


Application No.: US20070134178A1  Published: 14/Jun/2007

Title: Skin lightening complex

Applicant/Assignee:

Application No.: 11/302018   Filing Date: 12/Dec/2005

Abstract:A skin lightening complex having a skin lightening agent such as hydroquinone. The complex can be formulated in a concentrate form for later dilution as a product for topical application. The concentrate can be diluted such that the product is available as a pharmaceutical product with a high coincentration of active ingredients or as an over the counter product with a lower concentration. The concentrate is diluted with suitable carriers for the particular product. The formulation allows dilution of a high concentration of active skin lightening ingredient and has antioxidants and other ingredients for stable shelf life.

Priority:

Inventor: OBIOHA IHEATU [US]; SUKUTA TEMBI [US]


Application No.: US20070134180A1  Published: 14/Jun/2007

Title: Cosmetic compositions with encapsulated pigments and a method for using

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/301421   Filing Date: 13/Dec/2005

Abstract:There is a pigmented cosmetic composition. The composition has a cosmetically acceptable vehicle, a cosmetic active, and a plurality of encapsulated pigment particles. The particles have an encapsulant and an entrapped pigment within the encapsulant. The encapsulant has silicon dioxide and exhibits a refractive index of about 1.4 to about 1.6.

Priority:

Inventor: SIMARD CLAUDE C [US]; SHAH ARVIND N [US]


Application No.: US20070134183A1  Published: 14/Jun/2007

Title: Aminosulfonic acid compounds for promoting desquamation of the skin

Applicant/Assignee: L'OREAL

Application No.: 11/702164   Filing Date: 05/Feb/2007

Abstract:Aminosulfonic acid compounds having the structural formula (I): are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.

Priority: FR20000014864 Applic. Date: 2000-11-17; WO2001FR03522 Applic. Date: 2001-11-12; US2003-440314 Applic. Date: 2003-05-19

Inventor: GALEY JEAN-BAPTISTE [FR]; BERNARD DOMINIQUE [FR]; SIMONETTI LUCIE [FR]


Application No.: US20070134193A1  Published: 14/Jun/2007

Title: Cosmetic and/or pharmaceutical preparations

Applicant/Assignee:

Application No.: 11/546588   Filing Date: 12/Oct/2006

Abstract:A cosmetic or pharmaceutical composition containing an extract of a resurrection plant.

Priority: FR20010000492 Applic. Date: 2001-01-15; US2003-250870 Applic. Date: 2003-12-16; WO2002EP00053 Applic. Date: 2002-01-05

Inventor: PAULY GILLES [FR]; MOSER PHILIPPE [FR]; DANOUX LOUIS [FR]; FREIS OLGA [FR]; HENRY FLORENCE [FR]; PAULY-FLORENTINY MURIEL [FR]; GUEZENNEC ANNE [FR]; GUESNET JOELLE [FR]


Application No.: US20070134481A1  Published: 14/Jun/2007

Title: SOLUBLE PATCH

Applicant/Assignee: L'OREAL

Application No.: 11/567336   Filing Date: 06/Dec/2006

Abstract:An article, preferably a patch, containing: a support in the form of at least one sheet containing fibres that are water-soluble at a temperature of 0-30 DEG C., and a composition carried by the support, containing at least one water-soluble gelling agent which swells in less than 30 seconds in water at a temperature of 20 DEG C. to 30 DEG C.

Priority: FR20050053752 Applic. Date: 2005-12-07; US20050752051P Applic. Date: 2005-12-21

Inventor: AUBRUN-SONNEVILLE ODILE [FR]


Application No.: US20070135379A1  Published: 14/Jun/2007

Title: Anhydrous pharmaceutical composition associating a siliconated agent and solubilised active principle

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 10/591864   Filing Date: 18/Mar/2005

Abstract:The invention relates to an anhydrous pharmaceutical composition associating at least one type of active principle and one type of siliconated agent which comprises at least one type of organopolysiloxane elastomer, wherein said active principle is embodied in the solubilised form thereof in said composition.

Priority: FR20040002911 Applic. Date: 2004-03-22; WO2005FR50171 Applic. Date: 2005-03-18

Inventor: MALLARD CLAIRE [FR]; FERRARA EVE [FR]


Application No.: US20070135473A1  Published: 14/Jun/2007

Title: Method of treating tumors with azaxanthones

Applicant/Assignee: SUPRATEK PHARMA, INC

Application No.: 11/301930   Filing Date: 13/Dec/2005

Abstract:The use of azaxanthones for treating diseases associated with tumor cells which express one or more protein of S100 family, and in treating patients that have malignancies consisting of tumors of an epithelial or mesenchymel nature, where these compounds are effective in retarding the progression and/or metastasis of these tumors.

Priority:

Inventor: SEMOV ALEXANDRE [CA]; PIETRZYNSKI GRZEGORZ [CA]; ALAKHOV VALERY [CA]


Application No.: US20070135505A1  Published: 14/Jun/2007

Title: Aralkyl ester soft drugs

Applicant/Assignee:

Application No.: 11/652365   Filing Date: 11/Jan/2007

Abstract:The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug compound is modified by forming one or more of a predetermined chemical arrangement within the parent drug structure where the chemical arrangement is A-Phi-R-X-R'

where A is absent or is a tether moiety which allows for a metabolically stable chemical connection to be made to the parent drug compound

Phi is a substituted aryl or heteroaryl system that is already present within the parent drug compound or is specifically added to the parent drug compound via A

R is an alkyl or alkene containing chain either branched or unbranched from 0 to 10 carbons that is either also already present within the parent drug compound or is specifically added to the parent drug compound via connection to Phi

X is a carboxyl, sulfoxyl or phosphatyl function that is specifically added to the parent drug compound via connection to R

and, R' is an added alkyl, alkenyl, or aralkyl group either branched or unbranched containing from 1 to 10 carbons, other common leaving group, or a structural element already present as an inherent portion of the parent drug compound.

Priority: US2004-857683 Applic. Date: 2004-05-28; US2000-570485 Applic. Date: 2000-05-12

Inventor: ERHARDT PAUL W [US]


Application No.: US20070135777A1  Published: 14/Jun/2007

Title: Therapeutic article including a personal care composition and methods of making the therapeutic article

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/300601   Filing Date: 14/Dec/2005

Abstract:A therapeutic article includes a skin contact layer having a plurality of fibers forming a plurality of point-bearing surfaces configured for wear against a user's skin

a personal care composition disposed proximate the fibers

an external layer attached to the skin contact layer

and an intermediate layer interposed between the skin contact layer and the external layer, the intermediate layer being configured to activate the personal care composition, the external layer being configured to direct the activated personal care composition through the skin contact layer to treat the user.

Priority:

Inventor: GREENE SHARON L [US]; YANG KAIYUAN [US]; YANG SHU-PING [US]; WEI NING [US]; KYUNG JAI [US]; FISH JEFFREY E [US]


Application No.: US20070135929A1  Published: 14/Jun/2007

Title: Medical Devices and Applications of Polyhydroxyalkanoate Polymers

Applicant/Assignee: METABOLIX, INC

Application No.: 11/623593   Filing Date: 16/Jan/2007

Abstract:Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes,

bone graft substitutes, bone dowels, would dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rats. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Priority: US2004-020896 Applic. Date: 2004-12-22; US2002-136499 Applic. Date: 2002-05-01; US2000-535146 Applic. Date: 2000-03-24; US19990142238P Applic. Date: 1999-07-02; US19990126180P Applic. Date: 1999-03-25

Inventor: WILLIAMS SIMON F [US]; MARTIN DAVID P [US]; SKRALY FRANK A [US]


Application No.: US20070138672A1  Published: 21/Jun/2007

Title: Process for preparing a high stability microcapsule product and method for using same

Applicant/Assignee:

Application No.: 11/304090   Filing Date: 15/Dec/2005

Abstract:The present invention is directed to a process for preparing a capsule product through the increase in the polymerization cure temperature and cure time during the capsule-making process. The microcapsule products prepared according the process of the present invention exhibit enhanced retention of active materials in consumer products which promote instability.

Priority:

Inventor: LEE KAIPING [US]; POPPLEWELL LEWIS M [US]; ANASTASIOU THEODORE J [US]


Application No.: US20070138673A1  Published: 21/Jun/2007

Title: Process for Preparing a High Stability Microcapsule Product and Method for Using Same

Applicant/Assignee:

Application No.: 11/549998   Filing Date: 17/Oct/2006

Abstract:The present invention is directed to a process for preparing a capsule product through the increase in the polymerization cure temperature and cure time during the capsule-making process. The microcapsule products prepared according the process of the present invention exhibit enhanced retention of active materials in consumer products which promote instability.

Priority: US2005-304090 Applic. Date: 2005-12-15

Inventor: LEE KAIPING [US]; POPPLEWELL LEWIS MICHAEL [US]; ANASTASIOU THEODORE JAMES [US]


Application No.: US20070140042A1  Published: 21/Jun/2007

Title: Multicomponent packaging with static micromixer

Applicant/Assignee:

Application No.: 10/563191   Filing Date: 04/Jun/2004

Abstract:The packaging system has two storage chambers for separately storing two components and a static micromixer for mixing them to prepare a formulation. The static micromixer is provided with plural disks ( 1 ) arranged in a stack. Each disk ( 1 ) has at least one inlet opening ( 2 ) for a feed stream, which is connected via a linking channel ( 3 ) with at least one outlet opening ( 4 ) for outflow of the feed stream into a mixing zone ( 5 ). The linking channel ( 3 ) is divided into two or more part channels ( 7 ) by microstructure units ( 6 ). Each part channel has a respective width that is smaller than a width of the mixing zone ( 5 ). A method of in-situ preparation of a formulation by mixing the components in the packaging system is also described.

Priority: WO2004EP06041 Applic. Date: 2004-06-04

Inventor: SCHANZ GERHARD [DE]; SENDELBACH GERHARD [DE]


Application No.: US20070140993A1  Published: 21/Jun/2007

Title: Skincare compositions

Applicant/Assignee: RECKITT & COLMAN (OVERSEAS) LIMITED

Application No.: 10/590060   Filing Date: 15/Feb/2005

Abstract:There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises a cosmetically acceptable skincare composition in the form of a hydroalcoholic gel dispersion, the composition comprising salicylic acid or a salt thereof and a gelling agent in the form of a copolymer of acryloyl dimethyl tauric acid or a salt thereof. The compositions may be useful to cleanse the skin and the prophylactic or remedial treatment of acne.

Priority: GB20040003702 Applic. Date: 2004-02-19; WO2005GB00524 Applic. Date: 2005-02-15

Inventor: EVISON JANE [GB]


Application No.: US20070140994A1  Published: 21/Jun/2007

Title: Substituted hydrocarbyl functional siloxanes-silicone resin

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 10/592714   Filing Date: 30/Mar/2005

Abstract:Sunscreen compositions containing a hydrocarbyl functional organopolysiloxane are disclosed. The hydrocarbyl functional organopolysiloxane contains at least one siloxy unit of the formula -R<2>OCH2CH2OH, where R<2 >is a divalent hydrocarbon group containing 2 to 6 carbon atoms. The inclusion of the hydrocarbyl functional organopolysiloxane in the sunscreen composition improves the sun-protection factor (SPF) of the sunscreen component and various personal, medical and household care compositions containing the sunscreen composition.

Priority: US20040563662P Applic. Date: 2004-04-20; WO2005US10860 Applic. Date: 2005-03-30

Inventor: FECHT CASSANDRE M [US]; VANDORT HEIDE M [US]; STARK-KASLEY LORI A [US]; URRUTIA ADRIANA [MX]


Application No.: US20070140996A1  Published: 21/Jun/2007

Title: Synthesis of a nitroxide antioxidant and methods of use in cosmetic and dermatological compositions

Applicant/Assignee: JARROW FORMULAS, INC

Application No.: 11/640158   Filing Date: 15/Dec/2006

Abstract:The present invention provides a dermatological and/or cosmetic composition which includes a methoxycinnamate, and a cyclic nitroxide. The present invention further provides a method of synthesizing photo absorbing-antioxidant compounds and their use in dermatological and/or cosmetic compositions. In addition, the present invention relates to the use of methoxycinnamate, and nitroxide compounds for the preparation of a composition for the dermatological and/or cosmetic treatment of skin.

Priority: US20050750584P Applic. Date: 2005-12-15

Inventor: DAMIANI ELISABETTA [IT]; ASTOLFI PAOLA [IT]; GRECI LUCEDIO [IT]


Application No.: US20070140997A1  Published: 21/Jun/2007

Title: Photoprotective compositions containing a triazine derivative, an amide-based oil and a eutectic mixture of n-butylphthalimide/isopropylphthalimide

Applicant/Assignee: L'OREAL

Application No.: 11/646280   Filing Date: 28/Dec/2006

Abstract:Stable, topically applicable cosmetic/dermatological photoprotective compositions contain: a) at least one 1,3,5-triazine compound, b) at least one oil containing in its structure at least one amide structural unit, and c) at least one eutectic mixture of n-butylphthalimide and of isopropylphthalimide, and have enhanced sun protection factors and cosmetic properties.

Priority: FR20040051424 Applic. Date: 2004-07-02; WO2005EP07888 Applic. Date: 2005-06-13

Inventor: CANDAU DIDIER [FR]; FIANDINO CECILE [FR]


Application No.: US20070140999A1  Published: 21/Jun/2007

Title: TOPICAL SKIN CARE COMPOSITION CONTAINING REFINED PEANUT OIL

Applicant/Assignee: HILL DERMACEUTICALS, INC

Application No.: 11/668257   Filing Date: 29/Jan/2007

Abstract:A vehicle containing refined peanut oil for topical use in skin care and for use in skin care therapeutics, and a process for making the vehicle and a composition and therapeutic composition made from that process.

Priority: US2004-892153 Applic. Date: 2004-07-16; US2003-622560 Applic. Date: 2003-07-18

Inventor: PUGLIA NANCY [US]; ROTH JERRY [US]; RAMIREZ ROSARIO [US]


Application No.: US20070141013A1  Published: 21/Jun/2007

Title: Ampholytic anionic copolymers

Applicant/Assignee: BASF AKTIENGESELLSCHAFT BASF SE

Application No.: 10/582227   Filing Date: 08/Dec/2004

Abstract:Ampholytic copolymers which contain a molar excess of anionogenic and/or anionic groups, polyelectrolyte complexes which contain such an ampholytic copolymer, cosmetic and pharmaceutical compositions which contain at least one such copolymer or polyelectrolyte complex and the use of these copolymers and polyelectrolyte complexes are described.

Priority: DE20031057487 Applic. Date: 2003-12-09; WO2004EP13983 Applic. Date: 2004-12-08

Inventor: NGUYEN-KIM SON [DE]; MATHAUER KLEMENS [DE]; WOOD CLAUDIA [DE]; SCHUH GERD [DE]; PATWARDHAN DARSHAN [DE]


Application No.: US20070141014A1  Published: 21/Jun/2007

Title: Formulation assistants

Applicant/Assignee:

Application No.: 10/588461   Filing Date: 13/Jan/2005

Abstract:The invention relates to the use of compounds of the formula (I), where R<1>, R<2 >and R<3 >may be identical or different and are selected from: straight-chain or branched C1- to C24-alkyl groups, straight-chain or branched C3- to C24-alkenyl groups, straight-chain or branched C1- to C24-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C3- to C10-cycloalkyl groups and/or C3- to C12-cycloalkenyl groups, where the rings may in each case also be bridged by (CH2)n groups, where n=1 to 3, as formulation assistants for the preparation of cosmetic or dermatological compositions, to corresponding novel compounds, and to the preparation thereof.

Priority: DE200410006144 Applic. Date: 2004-02-07; WO2005EP00274 Applic. Date: 2005-01-13

Inventor: PFLUCKER FRANK [DE]; GRUNEWALD HANS-WERNER [DE]; DRILLER HANSJURGEN [DE]; SCHWARZ MICHAEL [DE]


Application No.: US20070141017A1  Published: 21/Jun/2007

Title: Penetration enhancing agent and method of its production from the hemp seeds

Applicant/Assignee: PARENTERAL, A.S

Application No.: 10/582979   Filing Date: 15/Dec/2004

Abstract:The conveying and absorption agent, preferably for the active substances of the pharmaceutical, dietetic, and cosmetic preparations, consists of the extract from the hemp seeds, obtained by action of carbon dioxide. Advantageously, the extract is a component of the fat or wax base of the pharmaceutical or cosmetic preparation, preferably composed of the propolis relieved of its pollen contents. According to the method of production of the conveying and absorption agent from the hemp seeds for the active substances of the pharmaceutical, dietetic, and cosmetic preparations, the hemp seeds are ground down to hemp flour, being then pressure-extracted with carbon dioxide to the hemp oil. The hemp seeds are ground down to fine-grain flour, which is then powered into the extraction cartridges that are inserted into the extractor. Extractor is then closed and the carbon dioxide is then driven into it at the temperature between 35 DEG C.-45 DEG C. and the pressure between 25 MPa and 35 MPa, advantageously 40 DEG C. and pressure 29 MPa. With the hemp oil extraction process slowed down, the carbon dioxide pressure in the extractor is reduced down to the ambient atmospheric pressure value and the hemp oil is separated from the carbon dioxide which is subsequently led away from the extractor to the reserve tank, where it will be stored in its supercritical condition. For removal of chlorophyll and waxes, 2%-35% in weight of the crushed silicon sand is mixed into the hemp oil extracted. Following the surface absorption, the crushed silicon sand is filtered out.

Priority: CZ20030003412 Applic. Date: 2003-12-15; WO2004CZ00086 Applic. Date: 2004-12-15

Inventor: HORSKA IRENA [CZ]


Application No.: US20070141018A1  Published: 21/Jun/2007

Title: Food composition comprising glucosamine

Applicant/Assignee: NESTEC S.A

Application No.: 10/595894   Filing Date: 19/Nov/2004

Abstract:The present invention relates to an orally ingestible food or pet food composition or cosmetic composition containing glucosamine generated from plant materials through a drying process for the maintenance of joint health or prevention, alleviation and/or treatment of osteoarthritis, or the improvement of the skin quality and prevention or restoration of age-related alterations of skin. It also relates to the use of the composition in the manufacture of a nutritional product, a supplement, a treat, a medicament or a cosmetic product and methods for the maintenance of bone health, prevention, alleviation and/or treatment of osteoarthritis, improvement of the skin quality and prevention or restoration of age-related alterations of skin which comprises administering an effective amount of the composition.

Priority: EP20030026498 Applic. Date: 2003-11-21; WO2004EP13184 Applic. Date: 2004-11-19

Inventor: COURTOIS DIDIER [FR]; MICHAUX STEPHANE [FR]; PETIARD VINCENT [FR]; TOUCHE ANDRE [FR]


Application No.: US20070141062A1  Published: 21/Jun/2007

Title: Control of proliferation and apoptosis in cancer cells

Applicant/Assignee:

Application No.: 11/413082   Filing Date: 28/Apr/2006

Abstract:The invention includes a method of inhibiting or reducing cellular proliferation through the use of one or more agents that prevent the association or interaction of pp32 polypeptides with the hyperphosphorylated form of Retinoblastoma protein. The invention also discloses agents that are useful in preventing the association or interaction of pp32 polypeptides with the hyperphosphorylated form of Retinoblastoma protein. The invention also discloses screening assays that utilize pp32 polypeptide fragments to identify candidate agents useful in preventing the association or interaction of pp32 polypeptides with the hyperphosphorylated form of Retinoblastoma protein. The invention further discloses diseases and/or disorders for which the disclosed compositions and methods are useful.

Priority: US20050675565P Applic. Date: 2005-04-28

Inventor: PASTERNACK GARY R [US]; ADEGBOLA ONIKEPE [US]


Application No.: US20070141118A1  Published: 21/Jun/2007

Title: Layered dosage form for a medicated tampon assembly

Applicant/Assignee:

Application No.: 11/303802   Filing Date: 15/Dec/2005

Abstract:A tampon adapted to deliver a therapeutic agent includes a tampon body having a distal end and a dosage form affixed to the distal end of the tampon body, the dosage form including a first active layer dispersible by a first mechanism, and an attachment layer dispersible by a second mechanism. Mechanisms include melting and dissolution.

Priority:

Inventor: DAMICO JOYCE A [US]; SIEBERS BRUCE M [US]; HASTINGS PATRICK R [US]; BURNETT STEVEN R [US]; CLENDENING CHRIS [US]


Application No.: US20070141628A1  Published: 21/Jun/2007

Title: Polyethylene binding peptides and methods of use

Applicant/Assignee:

Application No.: 11/607672   Filing Date: 01/Dec/2006

Abstract:Combinatorially generated peptides are provided that have binding affinity for polyethylene (PE). The peptides may be used to deliver benefit agents to various PE surfaces.

Priority: US20050750748P Applic. Date: 2005-12-15

Inventor: CUNNINGHAM SCOTT D [US]; LOWE DAVID J [US]; O'BRIEN JOHN P [US]; WANG HONG [US]; WILKINS ANTOINETTE E [US]


Application No.: US20070141629A1  Published: 21/Jun/2007

Title: Nylon binding peptides and methods of use

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/607723   Filing Date: 01/Dec/2006

Abstract:Combinatorially generated peptides are provided that have binding affinity for nylon (NY). The peptides may be used to deliver benefit agents to various NY surfaces.

Priority: US20050750598P Applic. Date: 2005-12-15

Inventor: CUNNINGHAM SCOTT D [US]; LOWE DAVID J [US]; O'BRIEN JOHN P [US]; WANG HONG [US]; WILKINS ANTOINETTE E [US]


Application No.: US20070142368A1  Published: 21/Jun/2007

Title: Substituted pyrazole compounds

Applicant/Assignee: MIIKANA THERAPEUTICS, INC

Application No.: 11/541484   Filing Date: 29/Sep/2006

Abstract:Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

Priority: US20050722217P Applic. Date: 2005-09-30; US20050732340P Applic. Date: 2005-10-31; US20050733868P Applic. Date: 2005-11-04

Inventor: XIAO XIAO-YI [US]; PATEL DINISH V [US]; WARD JOHN S [US]; BRAY MARK R [CA]; AGOSTON GREGORY E [US]; TRESTON ANTHONY M [US]


Application No.: US20070142474A1  Published: 21/Jun/2007

Title: Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof

Applicant/Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD

Application No.: 10/581546   Filing Date: 01/Dec/2004

Abstract:The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.

Priority: US20030526081P Applic. Date: 2003-12-02; WO2004IL01098 Applic. Date: 2004-12-01

Inventor: FLESCHER ELIEZER [IL]; KASHMAN YOEL [IL]; REISCHER DORIT [IL]; SHIMONY SHIRI [IL]


Application No.: US20070142521A1  Published: 21/Jun/2007

Title: Use of thermoplastic elastomers in a composition and compositions thereof

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/314634   Filing Date: 21/Dec/2005

Abstract:Compositions and methods for the formation of physically cross-linked thermoplastic elastomeric films are disclosed. The disclosed films are long-lasting, flexible, transfer resistant, and water-proof. The film-forming compositions comprise a thermoplastic elastomer, a tackifier resin, and a volatile solvent useful for formulating cosmetics, personal care products, and pharmaceutical compositions.

Priority:

Inventor: BRAHMS JOHN C [US]; MAITRA PRITHWIRAJ [US]; ZHENG TAO [US]


Application No.: US20070148105A1  Published: 28/Jun/2007

Title: Compositions and methods comprising magnetic particles for health use

Applicant/Assignee:

Application No.: 11/318191   Filing Date: 22/Dec/2005

Abstract:The present invention provides a topical composition comprising a topical composition base and a plurality of magnetic particles. The topical composition can further comprise one or more active agents. The magnetic particles and/or active agent(s) can optionally be encapsulated and/or coated. Methods for making and using the topical composition are also provided.

Priority:

Inventor: SPECTOR DONALD [US]


Application No.: US20070148110A1  Published: 28/Jun/2007

Title: Aqueous-alcoholic depigmenting gels comprising mequinol and adapalene

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 11/636432   Filing Date: 11/Dec/2006

Abstract:Stable, topically applicable cosmetic/pharmaceutical skin depigmentation compositions contain a combination depigmentation effective amount of mequinol and adapalene, and optionally, at least one sunscreen, formulated as aqueous-alcoholic gels or gel-creams in topically applicable, physiologically acceptable media therefor.

Priority: FR20040006338 Applic. Date: 2004-06-11; WO2005FR01393 Applic. Date: 2005-06-07

Inventor: ZANUTTO LESLIE [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]


Application No.: US20070148112A1  Published: 28/Jun/2007

Title: Foaming, color-changing topical composition and method of imparting a cosmetic effect

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/319947   Filing Date: 28/Dec/2005

Abstract:There is an anhydrous topical composition. The composition has a) an active ingredient

b) a base compound of a carbonate or bicarbonate salt of an alkali metal or an alkaline earth metal

c) an acid compound

and d) a cosmetically acceptable anhydrous vehicle. The base compound and the acid compound are reactable and are present in amounts sufficient to foam the topical composition when the topical composition is exposed to water. The topical composition changes color upon exposure to water. There is also a method for imparting a cosmetic effect to a topical surface.

Priority:

Inventor: DINGLEY AJAY G [US]; MARTIN SHARI [US]; ANDERSON GLEN T [US]


Application No.: US20070148113A1  Published: 28/Jun/2007

Title: Antiperspirant compositions comprising at least one dispersion of cationic colloidal silica particles, antiperspirant product, and cosmetic process for treating perspiration

Applicant/Assignee:

Application No.: 11/633441   Filing Date: 05/Dec/2006

Abstract:The present disclosure relates to the use of a dispersion of cationic colloidal particles of silica modified with a multivalent cation in a cosmetic composition, as an antiperspirant active agent. The present disclosure also relates to antiperspirant compositions comprising at least one dispersion of cationic colloidal particles of silica modified with a multivalent cation, as well as cosmetic processes for treating perspiration and body odor, employing the compositions disclosed herein.

Priority: FR20050053718 Applic. Date: 2005-12-05; US20060757848P Applic. Date: 2006-01-11

Inventor: LEMOINE CYRIL [FR]; ILEKTI PHILIPPE [FR]


Application No.: US20070148199A1  Published: 28/Jun/2007

Title: PREPARATIONS FOR TOPICAL SKIN USE AND TREATMENT

Applicant/Assignee:

Application No.: 11/676660   Filing Date: 20/Feb/2007

Abstract:Topical preparations for release of an active agent to the skin are provided. The preparations have an internal phase dispersed within an external phase. The internal phase includes a hydrophilic carrier and an enzyme active agent. The external phase comprises a silicone matrix.

Priority: US2003-660101 Applic. Date: 2003-09-10

Inventor: BOTT RICHARD R [US]; GEBERT MARK S [US]; KLYKKEN PAAL C [US]; MAZEAUD ISABELLE [FR]; THOMAS XAVIER J [US]


Application No.: US20070148219A1  Published: 28/Jun/2007

Title: Liposomal Nanowater-Containing Patch-Type Nanodermal Gel for Transdermal Delivery and Method for Preparing the Same

Applicant/Assignee: SPHERE TECH CO., LTD

Application No.: 11/425260   Filing Date: 20/Jun/2006

Abstract:Disclosed herein is a patch-type nanodermal gel including liposomal nanowater, which can deliver cosmetically active substances, such as those functioning to moisturize the skin, into and through the skin stably and effectively. The patch-type cosmetic composition for transdermal deliver, based on nanodermal gel, comprises nanowater in an amount from 0.01 to 80.0% by weight

a skin-compatible polymer in an amount from 0.01 to 10.0% by weight

and a polyhydric alcohol in an amount from 5.0 to 20.0% by weight, based on the total weight of the nanodermal gel.

Priority: KR20050131131 Applic. Date: 2005-12-28

Inventor: JEON JONG T [KR]; KIM YOUNG J [KR]; KIM JU Y [KR]


Application No.: US20070148256A1  Published: 28/Jun/2007

Title: Pharmacologic-functioning water and usage of the same

Applicant/Assignee: MIZ CO., LTD

Application No.: 10/576607   Filing Date: 22/Oct/2004

Abstract:The present invention provides a new pharmacologic-functioning water demonstrating pharmacologic function without any side effects, and usage of the same. The pharmacologic-functioning water, which demonstrates pharmacologic function without any side effects and includes antioxidant-functioning water as an active principle containing hydrogen-dissolved water, which is made up of molecular hydrogen used as a substrate that is included in raw water, and a precious metal colloid, which is included in the hydrogen-dissolved water and catalyzes the breaking reaction of the molecular hydrogen into a product of atomic hydrogen, is used for preventing and/or treating diseases.

Priority: JP20030364722 Applic. Date: 2003-10-24; WO2004JP15686 Applic. Date: 2004-10-22

Inventor: YANAGIHARA TOMOYUKI [JP]; SATOH BUNPEI [JP]; SHUDO TATSUYA [JP]


Application No.: US20070149440A1  Published: 28/Jun/2007

Title: TRANSFERRIN AND TRANSFERRIN-BASED COMPOSITIONS FOR DIABETES TREATMENT

Applicant/Assignee: ESSENTIAL SKINCARE, LLC

Application No.: 11/616378   Filing Date: 27/Dec/2006

Abstract:Embodiments of the present invention use transferrin or active derivatives to control or stabilize abnormally elevated levels of blood glucose in mammals, particularly humans. Embodiments of the invention also provide methods for enhancing survival of islet beta-cells in vivo and in vitro. In other embodiments, transferrin or active derivatives are used in combination with anti-diabetic medicaments or performing an insulin elevating procedure. In yet another embodiment the invention includes administering transferrin or an active derivative to reduce weight loss induced by type 1 diabetic condition.

Priority: US20050754446P Applic. Date: 2005-12-28

Inventor: KISS ZOLTAN [US]


Application No.: US20070149441A1  Published: 28/Jun/2007

Title: Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same

Applicant/Assignee: ORTHOGENE LLC

Application No.: 11/706922   Filing Date: 13/Feb/2007

Abstract:Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.

Priority: US2003-680000 Applic. Date: 2003-10-06; US1998-156829 Applic. Date: 1998-09-18

Inventor: AESCHLIMANN DANIEL [US]; BULPITT PAUL [US]


Application No.: US20070149508A1  Published: 28/Jun/2007

Title: Six membered heteroaromatic inhibitors targeting resistant kinase mutations

Applicant/Assignee: TARGEGEN, INC

Application No.: 11/591076   Filing Date: 31/Oct/2006

Abstract:A compound is provided, having the general structure (A): wherein A is an (un)substituted aryl or (un)substituted heteroaryl moiety, G is N, CH, or CR, R is an unsubstituted or substituted lower alkyl, Y is a hydrophobic linking moiety, and L is a substitutent as defined. The compound (A) can be used for treatment of various angiogenic and hematological-associated disorders, such as myeloproliferative disorder in patients who do not respond to kinase-inhibition therapy that comprises administering approved medications.

Priority: US20050733115P Applic. Date: 2005-11-02

Inventor: NORONHA GLENN [US]; CAO JIANGUO [US]; ZENG BINQI [US]; MAK CHI C [US]; MCPHERSON ANDREW [US]; RENICK JOEL [US]; PATHAK VED P [US]; CHOW CHUN [US]; PALANKI MOORTHY [US]; SOLL RICHARD M [US]; LOHSE DANIEL L [US]; HOOD JOHN D [US]; DNEPROVSKAIA ELENA [US]


Application No.: US20070149620A1  Published: 28/Jun/2007

Title: Use of piketprofen for the preparation of a pharmaceutical composition to treat rosacea

Applicant/Assignee:

Application No.: 10/580254   Filing Date: 10/Nov/2004

Abstract:The present invention relates to the use of piketoprofen for the preparation of novel pharmaceutical compositions and more particularly dermatological compositions that are useful for treating rosacea.

Priority: FR20030013665 Applic. Date: 2003-11-21; WO2004FR02898 Applic. Date: 2004-11-10

Inventor: DOLFI FABRIZIO [FR]; PILGRIM WILLIAM R [DE]


Application No.: US20070149731A1  Published: 28/Jun/2007

Title: PH modulated films for delivery of actives

Applicant/Assignee: MONOSOLRX, LLC

Application No.: 11/639013   Filing Date: 14/Dec/2006

Abstract:The invention relates to pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water

and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.

Priority: US2002-074272 Applic. Date: 2002-02-14; US20050754092P Applic. Date: 2005-12-27; US20010328868P Applic. Date: 2001-10-12

Inventor: MYERS GARRY L [US]


Application No.: US20070154402A1  Published: 05/Jul/2007

Title: Topical Pharmaceutical Foam Composition

Applicant/Assignee: COLLEGIUM PHARMACEUTICAL, INC

Application No.: 11/552457   Filing Date: 24/Oct/2006

Abstract:A stable topical alcohol-free aerosol foam containing one or more keratolytic agents is provided. The foam-forming formulation is an emulsion which contains an HFA propellant and one or more keratolytic agents. The emulsion has an oil phase and an aqueous, i.e. water-containing, phase. The active agent(s) may be present in either phase of the emulsion or dispersed in the emulsion. The oil phase may consist at least in part of the HFA propellant. Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and/or other excipients. The foam is stable on the skin, for example, for at least 5 minutes at body temperature, preferably at least 20 minutes at body temperature, and disappears into the skin upon rubbing or after prolonged standing. In one embodiment, the formulation contains an HFA propellant which does not contain additional co-solvents or co-propellants. The formulations demonstrate reduced intensity of the odor and/or color associated with the keratolytic agent(s) as compared to conventional formulations containing keratolytic agents.

Priority: US20050729788P Applic. Date: 2005-10-24

Inventor: TRUMBORE MARK W [US]; GURGE RONALD M [US]; HIRSH JANE C [US]


Application No.: US20070154416A1  Published: 05/Jul/2007

Title: Method of treating skin needing hyaluronic acid treatment

Applicant/Assignee:

Application No.: 11/647611   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to a cosmetic hyaluronic acid procedure involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755106P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154417A1  Published: 05/Jul/2007

Title: Method of treating skin requiring non-ablative procedure

Applicant/Assignee:

Application No.: 11/647612   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to non-ablative procedures involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755112P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154418A1  Published: 05/Jul/2007

Title: Method of treating skin requiring radiofrequency procedure

Applicant/Assignee:

Application No.: 11/647708   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to radiofrequency procedures involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755300P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154419A1  Published: 05/Jul/2007

Title: Method of treating skin requiring chemical peel procedure

Applicant/Assignee:

Application No.: 11/648056   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to chemical peel procedures involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755029P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154420A1  Published: 05/Jul/2007

Title: Method of treating skin subject to or affected by aesthetic surgical procedures

Applicant/Assignee:

Application No.: 11/648276   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to aesthetic surgical procedures involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755109P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154421A1  Published: 05/Jul/2007

Title: Method of treating skin needing collagen treatment

Applicant/Assignee:

Application No.: 11/648292   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to a collagen procedure involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755206P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154422A1  Published: 05/Jul/2007

Title: Method of treating skin needing ablative treatment

Applicant/Assignee:

Application No.: 11/648306   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to an ablative treatment involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755028P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154442A1  Published: 05/Jul/2007

Title: Method of treating skin requiring hair removal procedure

Applicant/Assignee:

Application No.: 11/647610   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to hair removal procedures involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755342P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154493A1  Published: 05/Jul/2007

Title: Method of treating skin needing botulinum toxin type a treatment

Applicant/Assignee:

Application No.: 11/647712   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to a botulinum toxin type A cosmetic procedure involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755349P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154500A1  Published: 05/Jul/2007

Title: COMPOSITION CONTAINING CONCAVE PARTICLES AND A DISPERSANT, PROCESSES AND USES

Applicant/Assignee: L'OREAL

Application No.: 11/614202   Filing Date: 21/Dec/2006

Abstract:The present invention relates to a composition containing concave particles, at least one dispersant for these concave particles, and optionally porous particles. This composition is nonpulverulent. The present invention also relates to a treatment process employing this composition and to the uses of this composition, in particular for conferring a matt appearance on keratinous substances and/or for softening imperfections of the relief of the skin and/or for concealing microrelief features, wrinkles, fine lines and pores of the skin.

Priority: FR20050013091 Applic. Date: 2005-12-21; US20060814889P Applic. Date: 2006-06-20

Inventor: CASSIN GUILLAUME [FR]; PORET FRISTOT SYLVIE [FR]


Application No.: US20070154501A1  Published: 05/Jul/2007

Title: Method of treating skin having incision from surgical procedures

Applicant/Assignee:

Application No.: 11/648277   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin in which an incision is made during a surgical procedure involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755343P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154502A1  Published: 05/Jul/2007

Title: Method of treating skin requiring microdermabrasion

Applicant/Assignee:

Application No.: 11/648291   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to microdermabrasion involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755110P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154503A1  Published: 05/Jul/2007

Title: Method of treating skin requiring skin cancer treatment

Applicant/Assignee:

Application No.: 11/648333   Filing Date: 29/Dec/2006

Abstract:A treatment regimen for treating skin subject to skin cancer treatments involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.

Priority: US20050755359P Applic. Date: 2005-12-30

Inventor: HATTENDORF JUDY [US]; CARLSON STEVE [US]


Application No.: US20070154527A1  Published: 05/Jul/2007

Title: Topical film composit