US Patents in Skin Care Actives and Formulations Granted from 2001 - 2006

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US PATENTS IN SKIN CARE ACTIVES GRANTED FROM 2001 to 2006



Patent No.: US6168782B1  Issued: 02/Jan/2001

Title: Elastomeric silicone containing an active ingredient

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/317459   Filing Date: 24/May/1999

Abstract:

Elastomeric silicones, especially elastomeric silicone polyethers, are prepared by combining and reacting (A) an =Si-H containing polysiloxane, (B) a mono-alkenyl polyether, (C) an active ingredient such as a vitamin, antimicrobial agent, sunburn prevention agent, astringent, or sex hormone, (D) an alpha,omega-unsaturated hydrocarbon, (E) a platinum catalyst, and (F) an oil. The reaction of components (A)-(F) is allowed to continue, forming a crosslinked three-dimensional gelled network of the elastomeric silicone polyether containing the active ingredient and the oil. The compositions are useful in personal and health care applications, personal hygiene, and household cleaning applications.

Priority:

Inventor: LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]; SMITH JANET MARY [US]


Patent No.: US6168799B1  Issued: 02/Jan/2001

Title: beta-D-glucan topical composition

Applicant/Assignee: BRENNEN MEDICAL, INC

Application No.: 09/231311   Filing Date: 13/Jan/1999

Abstract:

A topical composition for healing treatment of burns and wounds and scarring therefrom has as the active ingredient cereal-derived (1-3) (1-4) beta-D-glucan at about 0.5-15 w/w percent. The composition may be formulated in various forms with creams and gels being preferred for application to the skin.

Priority: US1997-957529 Applic. Date: 1997-10-24

Inventor: KLEIN BARBARA K [US]


Patent No.: US6168809B1  Issued: 02/Jan/2001

Title: Alkaline-earth metal salt for the treatment of ocular or palpebral pruritus and dysesthesia

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 08/630325   Filing Date: 10/Apr/1996

Abstract:

The invention relates to the use of an alkaline-earth metal salt in or for the preparation of a cosmetic or pharmaceutical composition, especially for topical application, for treating ocular or palpebral pruritus and/or ocular or palpebral dysesthesia. The cosmetic composition can be used for applying make-up to or removing make-up from sensitive eyes.

Priority: FR19950004266 Applic. Date: 1995-04-10

Inventor: DE LACHARRIERE OLIVIER [FR]; BRETON LIONEL [FR]


Patent No.: US6169110B1  Issued: 02/Jan/2001

Title: Rejuvenating the skin using a combination of vitamin A and alphahydroxy acids

Applicant/Assignee: VIVANT PHARMACEUTICALS

Application No.: 08/861502   Filing Date: 22/May/1997

Abstract:

Methods of accelerating skin rejuvenation and methods of skin care treatment are disclosed using a combination of vitamin A and alphahydroxy acids, such as the combination of vitamin A propionate and glycolic acid. The combination can be prepared in an alcohol-based carrier having concentrations ranging from approximately 0.01% to 10% vitamin A propionate, preferably 0.1% to 4%, and 0.1% to 30% glycolic acid, preferably 2% to 10% glycolic acid. In addition to alcohol, the carrier may also include propylene glycol, preservatives, thickeners and non-ionic surfactants or may be a cream or ointment-based formulation. The formulation is applied topically to the skin at a frequency which will produce a fine desquamation. The formulation may also be used to accelerate the penetration of other therapeutic agents into the skin.

Priority: US1996-755544 Applic. Date: 1996-11-21; US19950007410P Applic. Date: 1995-11-21

Inventor: FULTON JR JAMES E [US]


Patent No.: US6171579B1  Issued: 09/Jan/2001

Title: Synergistically UV-photoprotecting triazine/silicone compositions

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/258852   Filing Date: 26/Feb/1999

Abstract:

The invention relates to novel cosmetic and/or dermatological compositions, in particular for photoprotecting the skin and/or the hair, characterized in that they comprise, in a cosmetically acceptable support in particular of oil-in-water type, (i) as first screening agent, at least one specific 1,3,5-triazine derivative, and (ii) as second screening agent, a silicon derivative containing a benzotriazole function, the said first and second screening agents being present in the said compositions in an amount which is effective for producing synergistic activity with respect to the sun protection factors imparted.Application to protecting the skin and the hair against the effects of ultraviolet radiation.

Priority: FR19980002416 Applic. Date: 1998-02-27

Inventor: ALLARD DELPHINE [FR]; GOMBERT CHRIST GRAVE OVER E LE [FR]


Patent No.: US6171601B1  Issued: 09/Jan/2001

Title: Low residue antiperspirant gel-solid stick compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/771563   Filing Date: 20/Dec/1996

Abstract:

Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active

a solid non-polymeric gellant that is substantially free of dibenzylidene alditol, n-acyl amino acid derivatives, organic polymeric gellants, and inorganic thickening agents

and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm3)0.5 wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram-force to about 5,000 gram-force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 mum, and/or has an elongated particle morphology having an aspect ratio of greater than about 2. These antiperspirant gel-solid stick compositions provide improved low residue performance, antiperspirant and aesthetics.

Priority:

Inventor: GARDLIK JOHN MICHAEL [US]; GUSKEY GERALD JOHN [US]; MOTLEY CURTIS BOBBY [US]


Patent No.: US6171604B1  Issued: 09/Jan/2001

Title: Honey preparations

Applicant/Assignee:

Application No.: 09/348301   Filing Date: 07/Jul/1999

Abstract:

Methods and preparations for overcoming problems associated with the local application of honey are disclosed. The preparations include active ingredients of honey and a base including components selected from the group consisting of oils, gelling agents, emulsifiers and combinations thereof. Although honey is preferably used as is, the active ingredients of honey, including vitamins, sugars, enzymes, hormones, amino acids and minerals, may be extracted from honey or other natural products or synthesized. Potential applications for the present invention include topical treatments for therapeutic, cosmetic and nutritional purposes, including hair growth, hair loss prevention and wound healing.

Priority: US1997-835717 Applic. Date: 1997-04-09; US19960015348P Applic. Date: 1996-04-12

Inventor: MOUSA MAHMOUD A [US]


Patent No.: US6171605B1  Issued: 09/Jan/2001

Title: Self tanning compositions containing DHA and propolis extract

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 09/349913   Filing Date: 08/Jul/1999

Abstract:

The present invention relates to self-tanning compositions comprising an effective amount of DHA in combination with an effective amount of propolis extract. The compositions provide self-tanning compositions which can produce a tan with enhanced coloration. The self-tan produced using the compositions of the present invention is more natural looking. In another embodiment of the present invention, the compositions comprise DHA combined with caffeic acid phenethyl ester.

Priority:

Inventor: BEVACQUA ANDREW J [US]; LAHANAS KONSTANTINOS M [US]; MUIZZUDDIN NEELAM [US]; VRABIE NICOLAE [US]


Patent No.: US6172084B1  Issued: 09/Jan/2001

Title: Quinoline-indole antimicrobial agents, uses and compositions related thereto

Applicant/Assignee: SEPRACOR, INC

Application No.: 09/099640   Filing Date: 18/Jun/1998

Abstract:

The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.

Priority: US1998-045051 Applic. Date: 1998-03-19; US1997-878781 Applic. Date: 1997-06-19

Inventor: CUNY GREGORY D [US]; HAUSKE JAMES R [US]; HEEFNER DONALD L [US]; HOEMANN MICHAEL Z [US]; KUMARAVEL GNANASAMBANDAM [US]; MELIKIAN-BADALIAN ANITA [US]; ROSSI RICHARD F [US]


Patent No.: US6172250B1  Issued: 09/Jan/2001

Title: Preparation process of biologically active silicon compounds in a concentrated form

Applicant/Assignee: EXSYMOL S.A.M

Application No.: 08/647907   Filing Date: 16/Jul/1996

Abstract:

A process for the preparation of biologically active silicon compounds by hydrolysis of a precursor which produces a compound which prevents the formation of polymers from the silicon hydrolyzed bonds.

Priority: FR19940012089 Applic. Date: 1994-09-30; WO1995FR01267 Applic. Date: 1995-09-29

Inventor: SEGUIN MARIE-CHRISTINE [MC]; GUEYNE JEAN [MC]; NICOLAY JEAN-FRANCOIS [FR]; FRANCO ANDRE [FR]


Patent No.: US6174521B1  Issued: 16/Jan/2001

Title: Gel deodorant compositions having reduced skin irritation

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/071100   Filing Date: 01/May/1998

Abstract:

Disclosed are gel deodorant compositions comprising (a) from about 0.001% to about 50% by weight of a deodorant active, fragrance, or combination thereof

(b) from about 0.01% to about 20% by weight of a gellant

(c) from about 5% to about 90% by weight of a polymeric alcohol having at least one free hydroxyl group and also having from about 2 to about 80 alkoxylate radicals wherein the alkoxylate radical contains from about 2 to about 6 carbon atoms

(d) from about 5% to about 89% by weight of a nonpolymeric alcohol having at least two free hydroxyl groups, and also having from about 4 to about 20 carbon atoms, wherein the weight ratio of the polymeric to nonpolymeric alcohol is from about 18:1 to about 1:5

(e) from zero percent to about 10% by weight of glycerin

and (f) from about 0.01% to about 89% by weight of water. Also disclosed is a method of controlling malodor associated with perspiration by topical application of any deodorant composition containing a select combination of triclosan and triclocarban. All of these compositions remain clear or translucent over extended periods of time, and provide little or no skin irritation in addition to improved cosmetic benefits such as dry feel, ease of application, emolliency, fragrance longevity, and no powdery residue.

Priority:

Inventor: LI LI [CN]; ALAVA NORMA DIMACULANGAN [US]; MOTLEY CURTIS BOBBY [US]; SWAILE DAVID FREDERICK [US]; GUSKEY GERALD JOHN [US]; ORR THOMAS VINCENT [US]


Patent No.: US6174546B1  Issued: 16/Jan/2001

Title: Transdermal pressure sensitive adhesive drug delivery system

Applicant/Assignee: ADHESIVES RESEARCH, INC

Application No.: 09/562450   Filing Date: 01/May/2000

Abstract:

A transdermal drug delivery system is provided which includes an optionally crosslinked macromer-reinforced (meth)acrylic ester base copolymer pressure sensitive adhesive wherein the macromer includes repeat hydrophilic units.

Priority: US1999-255271 Applic. Date: 1999-02-23; US1997-803594 Applic. Date: 1997-02-21

Inventor: THERRIAULT DONALD J [US]; ZAJACZKOWSKI MICHAEL J [US]; STUTZMAN BARBARA A [US]


Patent No.: US6177066B1  Issued: 23/Jan/2001

Title: Solid deodorant composition

Applicant/Assignee: L'OREAL

Application No.: 09/274879   Filing Date: 23/Mar/1999

Abstract:

The invention relates to a solid deodorant composition, which is essentially anhydrous and comprises, as a solidifying agent, a mixture of waxes containing at least one synthetic polyethylene wax having a melting point of greater than 80 DEG C., and at least one wax of natural origin having a melting point of greater than 80 DEG C., as well as at least one deodorant active principle and a process for reducing the flow of sweat, and for masking, improving or reducing the unpleasant smell resulting from the decomposition of human sweat by bacteria using said composition.

Priority: FR19980003539 Applic. Date: 1998-03-23

Inventor: PATAUT FRANCOISE [FR]; AUBERT LIONEL [FR]


Patent No.: US6177068B1  Issued: 23/Jan/2001

Title: Vinyl amide polymer delivery system for hair and skin treating compositions

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 09/203910   Filing Date: 02/Dec/1998

Abstract:

A cosmetically active oil-in-water (o/w) or water-in-oil (w/o) emulsion, for topical applications comprising (a) the reaction product of a non-aqueous, heterogeneous polymerization of a liquid reaction mixture containing between about 5 and about 70%, preferably 10-40%, by weight, of N-vinylamide monomer in an oil solvent, a free radical initiator, between about 0.1 and about 2.5% by weight of a crosslinking agent and optionally a surfactant, (b) water sufficient to form said emulsion, (c) a cosmetically active hair and/or skin treating chemical or chemical composition and optionally (d) a surfactant.

Priority: US1997-988121 Applic. Date: 1997-12-10

Inventor: SHIH JENN S [US]; CHUANG JUI-CHANG [US]; PLOCHOCKA KRYSTYNA [US]


Patent No.: US6177071B1  Issued: 23/Jan/2001

Title: Polar solvent-in-oil emulsions and multiple emulsions

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/498714   Filing Date: 07/Feb/2000

Abstract:

One composition is a non-aqueous polar solvent-in-oil emulsion containing a non-aqueous polar solvent phase dispersed in a silicone oil continuous phase by an emulsifier. A second composition is a non-aqueous polar solvent-in-oil-in-water multiple emulsion of the type PS1/O/W which contains a non-aqueous polar solvent phase PS1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS1/O by an emulsifier. The primary emulsion PS1/O is dispersed in a second continuous aqueous phase W to form multiple emulsion PS1/O/W. A third composition is a non-aqueous polar solvent-in-oil-in-non-aqueous polar solvent multiple emulsion of the type PS1/O/PS2 which contains a non-aqueous polar solvent phase PS1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS1/O by an emulsifier. The primary emulsion PS1/O is dispersed in a second continuous non-aqueous polar solvent phase PS2 to form multiple emulsion PS1/O/PS2.

Priority: US1999-435561 Applic. Date: 1999-11-08

Inventor: LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]; SMITH JANET MARY [US]


Patent No.: US6177089B1  Issued: 23/Jan/2001

Title: Use of at least one sulphonic acid for stimulating renewal and/or epidermal repair and for combatting cutaneous aging and conditions

Applicant/Assignee: L'OREAL

Application No.: 08/709538   Filing Date: 06/Sep/1996

Abstract:

The use of specific sulphonic acids or hydrates thereof in or for the preparation of a cosmetic or dermatological composition for achieving various effects on the skin, such as promoting desquamation of the skin, stimulating epidermal renewal, combatting intrinsic and extrinsic cutaneous aging. A process for the non-therapeutic treatment of the skin intended to achieve such effects, such as to promote the desquamation of the skin.

Priority: FR19950010483 Applic. Date: 1995-09-07

Inventor: MAIGNAN JEAN [FR]


Patent No.: US6177091B1  Issued: 23/Jan/2001

Title: Non-migrating make-up or care composition containing an organopolysiloxane and a fatty phase

Applicant/Assignee: L'OREAL

Application No.: 08/994989   Filing Date: 19/Dec/1997

Abstract:

A non-migrating composition containing a solid, partially crosslinked, elastomeric organopolysiloxane and a fatty phase containing at least one non-volatile oil and at least one wax, particularly for the care or make up the lips and the face. This composition is gentle to apply, spreads easily, is non-sticky and does not dry the skin or the lips.

Priority: FR19960015985 Applic. Date: 1996-12-24

Inventor: BARA ISABELLE [FR]; AUGUSTE FREDERIC [FR]


Patent No.: US6178922B1  Issued: 30/Jan/2001

Title: Mastication articles possessing microbe-inhibiting properties

Applicant/Assignee: SEEFAR TECHNOLOGIES, INC

Application No.: 09/250072   Filing Date: 12/Feb/1999

Abstract:

A mastication article for a domestic animal comprising tough chew-resistant material defining a shape in the form of a small article for enticing or being retrieved by a domestic animal, and an effective amount of microbe-inhibiting agent applied to or incorporated in the material. The mastication articles may be fabricated in various shapes, designs, and styles. A process for applying the microbe-inhibiting agent to the material for forming the mastication article is disclosed. Application methods include spraying and soaking the article, and incorporating the agent within a resin or material for forming the article. The article can be digestible in whole or in part.

Priority: US1999-241591 Applic. Date: 1999-02-02; US1998-059956 Applic. Date: 1998-04-14; US19970043014P Applic. Date: 1997-04-15

Inventor: DENESUK MATTHEW [US]; UHLMANN EUGENIE V [US]


Patent No.: US6180122B1  Issued: 30/Jan/2001

Title: Solid cosmetic composition and uses thereof

Applicant/Assignee: L'OREAL

Application No.: 09/215296   Filing Date: 18/Dec/1998

Abstract:

A solid composition free of fillers, comprising an aqueous phase, wherein said aqueous phase comprises a hydrocolloid combination of gellane gum and at least one other hydrocolloid, wherein said gellane gum is present in an amount of at least 2% by weight, relative to the total weight of the composition, and wherein said hydrocolloid combination is present in an amount of less than 20% of the total weight of the composition, formable as tubes, pencils or bars, and useful to care for and/or treat the skin, the scalp, the hair or mucous membranes, to make up the skin and/or keratin fibers such as the eyelashes and the hair, and to style and/or shape keratin fibers, and in particular the hair.

Priority: FR19970016173 Applic. Date: 1997-12-19

Inventor: ROULIER VERONIQUE [FR]; QUEMIN ERIC [FR]


Patent No.: US6180123B1  Issued: 30/Jan/2001

Title: Composition for topical application comprising an olefin copolymer of controlled crystallization and use of such a copolymer in the manufacture of compositions for topical application

Applicant/Assignee: L'OREAL

Application No.: 09/295414   Filing Date: 21/Apr/1999

Abstract:

A composition for application to keratinous substances, comprising:a liquid fatty phase and an effective amount of at least one copolymer which is soluble or dispersible in the liquid fatty phase which is selected from crystalline olefin copolymers having a degree of crystallinity of at most 50%.

Priority: FR19980004950 Applic. Date: 1998-04-21

Inventor: MONDET JEAN [FR]


Patent No.: US6180416B1  Issued: 30/Jan/2001

Title: Method and device for predicting physiological values

Applicant/Assignee: CYGNUS, INC

Application No.: 09/163856   Filing Date: 30/Sep/1998

Abstract:

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

Priority:

Inventor: KURNIK RONALD T [US]; OLIVER JONATHAN JAMES [US]; POTTS RUSSELL O [US]; WATERHOUSE STEVEN RICHARD [US]; DUNN TIMOTHY C [US]; JAYALAKSHMI YALIA [US]; LESHO MATTHEW J [US]; TAMADA JANET A [US]; WEI CHARLES W [US]


Patent No.: US6180669B1  Issued: 30/Jan/2001

Title: Method for treatment of dermatological disorders

Applicant/Assignee: TAMARKIN PHARMACEUTICAL INNOVATION LTD

Application No.: 09/286236   Filing Date: 05/Apr/1999

Abstract:

A compound effect for the treatment of dermatological disorders comprises a mono- or diester of an alpha,omega-dicarboxylic acid, wherein the alcohol moiety of the said ester comprises a keratolytically active alcohol. The compound may have the formula,where n is in the range of 6 to 12

m is in the range of 0 to 8

R' is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR'', CONHR'' and COOR''

R'' is selected from the group consisting of alkyl, aryl, alkenyl, and benzyl

and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X.

Priority: WO1997IB01428 Applic. Date: 1997-11-12; US19960030512P Applic. Date: 1996-11-12

Inventor: TAMARKIN DOV [IL]


Patent No.: US6183757B1  Issued: 06/Feb/2001

Title: Mild, rinse-off antimicrobial cleansing compositions which provide improved immediate germ reduction during washing

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 08/868982   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to a rinse-off antimicrobial cleansing composition effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts. molds and viruses comprising from about 0.001% to about 5% of an antimicrobial active

from about 1% to about 80% of an anionic surfactant

from about 0.1% to about 12% of a proton donating agent

and from about 3% to about 98.899% of water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the rinse-off antimicrobial cleansing composition has an One-wash Immediate Germ Reduction Index of greater than about 2.5. The invention also encompasses methods for reducing the number of germs from the skin using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; CEN WEI [US]; BAKKEN THERESA ANNE [US]


Patent No.: US6183761B1  Issued: 06/Feb/2001

Title: Compositions for regulating skin appearance

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/267852   Filing Date: 12/Mar/1999

Abstract:

The present invention relates to compositions for preventing or treating skin disorders using vitamin B3 compounds and polycyclic compounds. The present invention also relates to methods for regulating skin condition.

Priority: US19980078158P Applic. Date: 1998-03-16

Inventor: BISSETT DONALD LYNN [US]; OBLONG JOHN ERICH [US]


Patent No.: US6183763B1  Issued: 06/Feb/2001

Title: Antimicrobial wipes which provide improved immediate germ reduction

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 08/868687   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3

and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; CEN WEI [US]; BAKKEN THERESA ANNE [US]


Patent No.: US6183770B1  Issued: 06/Feb/2001

Title: Carrier patch for the delivery of agents to the skin

Applicant/Assignee: ACUTEK INTERNATIONAL

Application No.: 09/292625   Filing Date: 15/Apr/1999

Abstract:

A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

Priority:

Inventor: MUCHIN JEROME D [US]; MUCHIN MICHAEL P [US]


Patent No.: US6183771B1  Issued: 06/Feb/2001

Title: Transdermal compositions containing levosimendan

Applicant/Assignee: ORION CORPORATION

Application No.: 09/214295   Filing Date: 23/Mar/1999

Abstract:

Transdermal administration of levosimenden or (-)-[[4-(1,4,5,6-tetahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono]propanedinitrile or a pharmaceutically acceptable salt thereof is disclosed. Transdermal preparations of levosimenden can be in the form of e.g. ointment, emulsion, lotion, solution, gel, cream, patch or transdermal delivery device including iontophoretic device.

Priority: WO1997FI00412 Applic. Date: 1997-06-26; GB19960014098 Applic. Date: 1996-07-05

Inventor: URTTI ARTO [FI]; HIRVONEN JOUNI [FI]; LEHTONEN LASSE [FI]; ANTILA SAILA [FI]


Patent No.: US6184252B1  Issued: 06/Feb/2001

Title: 2-amino-1,3-alkanediol compositions for inducing/stimulating hair growth and/or retarding hair loss

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 08/801315   Filing Date: 18/Feb/1997

Abstract:

Topically applicable hair growth-/hair loss-affecting cosmetic/pharmaceutical compositions for treating mammalian subjects with hair or scalp disorders, comprise an effective amount of at least one 2-amino-1,3-alkanediol compound having the structural formula (I):formulated into a physiologically topically acceptable carrier medium therefor.

Priority: FR19960001886 Applic. Date: 1996-02-15

Inventor: FAGOT DOMINIQUE [FR]; GAILLARD OLIVIER [FR]; PHILIPPE MICHEL [FR]; BERNARD BRUNO [FR]


Patent No.: US6184277B1  Issued: 06/Feb/2001

Title: Composition comprising an organopolysiloxane gel

Applicant/Assignee: L'OREAL

Application No.: 08/994433   Filing Date: 19/Dec/1997

Abstract:

A care composition containing, as gelling agent, at least one partially crosslinked, elastomeric solid organopolysiloxane combined with a fatty phase containing at least one polar oil and at least one cosolvent with a silicone structure comprising a chain which is pendent and/or at the end of a silicone structure, this chain being linear or branched and containing from 3 to 12 carbon atoms. This cosolvent is in particular volatile at ambient temperature, imparting coolness when applied.

Priority: FR19960015986 Applic. Date: 1996-12-24

Inventor: BARA ISABELLE [FR]


Patent No.: US6186966B1  Issued: 13/Feb/2001

Title: Hardenable orthopaedic support with improved configuration

Applicant/Assignee: ROYCE MEDICAL CO

Application No.: 09/307300   Filing Date: 07/May/1999

Abstract:

An orthopaedic support assembly is formed of a double-knit type fabric material with spaced interwoven layers formed of high strength materials and an open-work matrix of filaments or threads interconnecting the layers. The fabric preferably includes high strength stiff filaments of fiberglass, carbon fibers, or aramids and thermoplastic material to facilitate heat bonding of cut edges. The fabric is impregnated with a water-hardenable material. The support material or product is packaged in a water-vapor impermeable package

and is opened and water is supplied to the fabric when it is applied to the part of the anatomy requiring support. The fabric may be included in a soft goods support including a water distribution network and straps to hold the support in place. The double-knit type material may be variable in thickness and may be three dimensional in its configuration. An orthopaedic support or splint may have an inner core material of the double-knit type fabric, an impermeable stretch bonded laminate layer on one side, and a microporous plastic layer on the other side to facilitate water activation of the core material.

Priority: US1998-088905 Applic. Date: 1998-06-02

Inventor: GRIM TRACY E [US]; IGLESIAS JOSEPH M [US]; SPEAKES KELLY M [US]; CAMPOS MICHAEL [US]; PELOTE STEVEN T [US]


Patent No.: US6186991B1  Issued: 13/Feb/2001

Title: Disposable article having a responsive system including a mechanical actuator

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/106225   Filing Date: 29/Jun/1998

Abstract:

Disposable articles such as diapers, incontinent briefs, diaper holders and/or inserts, training pants, feminine hygiene garments, tampons and the like having a responsive system. The article includes a sensor that detects an input and a mechanical actuator that is adapted to perform a responsive function upon bodily waste, a wearer, the article or a component or components thereof.

Priority:

Inventor: ROE DONALD C [US]; ALLEN PATRICK J [US]; EHRNSPERGER BRUNO J [DE]; SCHMIDT MATTIAS [DE]; RONN KARL P [US]


Patent No.: US6187300B1  Issued: 13/Feb/2001

Title: Antiperspirant cream compositions having improved wash-off and antiperspirant efficacy

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/991819   Filing Date: 17/Dec/1997

Abstract:

Disclosed are anhydrous antiperspirant cream compositions that have improved wash-off performance and good antiperspirant efficacy, which compositions have a penetration force value of from about 75 gram.force to about 500 gram.force, a delta stress value of from about 300 dyne/cm2 to about 8,000 dyne/cm2 as measured after extrusion of the composition through a shear force delivery means, and a static yield stress value of at least about 1,000 dyne/cm2 as measured after extrusion of the composition through a shear force delivery means. These compositions comprise from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant wherein the anhydrous liquid carrier has a solubility parameter of from about 3 to about 13, from about 5% to about 35% by weight of a particulate antiperspirant active, and from about 0.001% to about 5% by weight of an anhydrous liquid surfactant which is selected from the group consisting of nonionic surfactant, amphoteric surfactant, and combinations thereof. Also disclosed are methods of using and making the compositions.

Priority:

Inventor: MOTLEY CURTIS BOBBY [US]; SCHRAER ROBERT MICHAEL [US]; TROYAN CHRISTINA MARIE [US]


Patent No.: US6187938B1  Issued: 13/Feb/2001

Title: omega-amino acid derivatives, processes of their preparation and their use

Applicant/Assignee: BOCHEMIE, S.R.O

Application No.: 09/402388   Filing Date: 21/Dec/1999

Abstract:

The invention relates to amino acid derivatives of general formula (I), wherein R1 is H or CH3, X is H or NR2R3, wherein R2 is H, CH3, COH or COCH3 and R3 is H, CH3 or COO-Z wherein Z is R2R3 NH+CHR1(CH2)nCOO(CH2)mCH2Y

Y is H, CH3 or NHR4, wherein R4 a COO-NH3+CH2(CH2)mOOC(CH2)nCH3, the meaning of group (CH2)m being selected from alkyls, secondary alkyls, monocycloalkyls, bicycloalkyls and tricycloalkyls having from 4 to 15 carbon atoms and n having a value of from 3 to 14. omega-Amino acid derivatives of the invention are prepared by reacting a primary or secondary or monocyclic or bicyclic or tricyclic alcohol with the reaction product of an amino acid or an N-substituted amino acid with thionyl chloride, whereafter the amino group, which has been released by an amine, reacts with carbon dioxide providing a derivative of carbamic acid, or by directly reacting a primary or secondary or monocyclic or bicyclic or tricyclic alcohol with an N-substituted amino acid in the presence of a condensing agent giving the corresponding ester of the N-substituted amino acid. Thus produced compounds of formula (I) can be used as transdermal penetration enhancers. Incorporation of from 0.1 w/w percent to 5.0 w/w percent of a compound of the invention as a transdermal penetration enhancer in the vehicle of a topically applied pharmaceutical or cosmetic composition enhances transdermal penetration of pharmaceutical agents through the human or animal skin. Included further are transdermal penetration enhancers consisting of at least one compound of formula (I).

Priority: CZ19970001027 Applic. Date: 1997-04-04; WO1998CZ00017 Applic. Date: 1998-04-01

Inventor: HRABALEK ALEXANDR [CZ]; DOLEZAL PAVEL [CZ]; FARSA OLDRICH MGR [CZ]; KREBS ALES MGR [CZ]; KROUTIL ALES MGR [CZ]; ROMAN MARTIN [CZ]; SKLUBALOVA ZDENKA PHARMDR [CZ]


Patent No.: US6190664B1  Issued: 20/Feb/2001

Title: Depigmenting cosmetic skin-care composition and use thereof

Applicant/Assignee: C 3 D

Application No.: 08/981701   Filing Date: 06/Feb/1998

Abstract:

A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one alpha-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-gamma-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, alpha-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component. The use of said composition for preparing a drug or in a cosmetic method is also disclosed.

Priority: FR19950008242 Applic. Date: 1995-07-07; WO1996FR01051 Applic. Date: 1996-07-05

Inventor: DAMPEIROU CHRISTIAN [FR]


Patent No.: US6190674B1  Issued: 20/Feb/2001

Title: Liquid antimicrobial cleansing compositions

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 08/869117   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5% of an antimicrobial active, from about 8% to about 18% of an anionic surfactant, from about 2% to about 12% of a proton donating agent

from about 1% to about 30% of a lipophilic skin moisturizing agent

from about 0.1% to about 4% of a stabilizer

and from about 35% to about 88.8% of water. At least about 67% of the anionic surfactant comprises a mixture of Class A and Class C surfactant. The weight ratio of Class A surfactant to Class C surfactant ranges from about 5:1 to about 1:2. The composition is adjusted to a pH of from about 3.5 to about 4.5.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; GRIESHOP BAIER KATHLEEN [US]; BARTOLO ROBERT GREGORY [US]; BAKKEN THERESA ANNE [US]; SINE MARK RICHARD [US]


Patent No.: US6190675B1  Issued: 20/Feb/2001

Title: Mild, rinse-off antimicrobial liquid cleansing compositions which provide improved residual benefit versus gram positive bacteria

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 08/969049   Filing Date: 12/Nov/1997

Abstract:

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent

and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 1.8, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

Priority: US1997-868695 Applic. Date: 1997-06-04

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; CEN WEI [US]; BAKKEN THERESA ANNE [US]; CLAPP MANNIE LEE [US]; WARREN RAPHAEL [US]


Patent No.: US6190678B1  Issued: 20/Feb/2001

Title: Cleansing and conditioning products for skin or hair with improved deposition of conditioning ingredients

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/148540   Filing Date: 04/Sep/1998

Abstract:

The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and consistently conditioning the skin or hair. These products are used by the consumer by wetting the dry product with water. The product comprises of a water insoluble substrate, a lathering surfactant, and a conditioning component having a lipid hardness value of at least about 0.02 kg. This invention also encompasses methods for providing consistent deposition of conditioning agents to the skin or hair. The invention also encompasses methods for cleansing and conditioning the skin or hair using these products and to methods for manufacturing these products.

Priority: US19970058093P Applic. Date: 1997-09-05

Inventor: HASENOEHRL ERIK JOHN [US]; MCATEE DAVID MICHAEL [US]


Patent No.: US6190689B1  Issued: 20/Feb/2001

Title: Hydrophilic pressure sensitive hot-melt adhesives

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME GMBH

Application No.: 08/737224   Filing Date: 13/Nov/1996

Abstract:

A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.

Priority: DE19944416927 Applic. Date: 1994-05-13; WO1995EP01724 Applic. Date: 1995-05-08

Inventor: HOFFMANN HANS-RAINER [DE]; ROREGER MICHAEL [DE]


Patent No.: US6190887B1  Issued: 20/Feb/2001

Title: Expression of an exogenous gene in a mammalian cell by use of a non-mammalian DNA virus having an altered coat protein

Applicant/Assignee: THE GENERAL HOSPITAL CORPORATION BIOGEN, INC

Application No.: 09/514953   Filing Date: 28/Feb/2000

Abstract:

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) having an altered coat protein, the genome of which virus carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by (1) providing to a cell a therapeutically effective amount of a non-mammalian DNA virus having an altered coat protein, the genome of which virus carries an exogenous, therapeutic gene and (2) growing the cell under conditions such that the exogenous gene is expressed in the mammal.

Priority: US1997-927317 Applic. Date: 1997-09-11; US19960026297P Applic. Date: 1996-09-11

Inventor: BOYCE FREDERICK M [US]; BARSOUM JAMES G [US]


Patent No.: US6191339B1  Issued: 20/Feb/2001

Title: Thermal effect patch and the use thereof

Applicant/Assignee: L'OREAL

Application No.: 09/272205   Filing Date: 19/Mar/1999

Abstract:

The invention relates to a patch for application to the skin. The patch comprises: a reflecting layer that reflects the infrared radiation released by the human body, and between said reflecting layer and said face for application to the skin: a matrix made of a material having self-adhesive properties and comprising at least an acrylic or vinyl polymer whose adhesive properties increase with temperature over the range 20 DEG C. to 40 DEG C.

and in said matrix at least one active substance having an effect on the skin.

Priority: FR19980003588 Applic. Date: 1998-03-24

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6193975B1  Issued: 27/Feb/2001

Title: Use of potentilla erecta extract in the cosmetic and pharmaceutical field

Applicant/Assignee: LVMH RECHERCHE

Application No.: 09/297679   Filing Date: 06/May/1999

Abstract:

The invention relates to the use of an extract of the plant Potentilla erecta in the field of cosmetics and pharmacy, especially in dermatology. The invention more particularly relates to any application in which it is sought to reinforce the dermo-epidermal junction or to improve hair condition, by the improvement of the synthesis of collagen VII by keratinocytes and/or fibroblasts. In particular, these applications concern toning of the skin, diminishing of wrinkles or hair care. The invention also relates to a novel method of culture of cells, in particular of human fibroblasts or keratinocytes, for promoting the formation of collagen VII.

Priority: FR19960013585 Applic. Date: 1996-11-07; WO1997FR01988 Applic. Date: 1997-11-06

Inventor: BONTE FREDERIC [FR]; DUMAS MARC [FR]; CHAUDAGNE CATHERINE [FR]; MEYBECK ALAIN [FR]


Patent No.: US6197315B1  Issued: 06/Mar/2001

Title: Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 08/869116   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; CEN WEI [US]; BAKKEN THERESA ANNE [US]


Patent No.: US6197319B1  Issued: 06/Mar/2001

Title: Cosmetic compositions containing polysaccharide/protein complexes

Applicant/Assignee: REVLON CONSUMER PRODUCTS CORPORATION

Application No.: 09/456575   Filing Date: 08/Dec/1999

Abstract:

In an emulsion cosmetic composition for application to skin containing water and at least one surfactant, the improvement wherein the composition also contains a water soluble, protein polysaccharide complex ("PPC") having a net positive or negative charge, which is the reaction product of at least one protein and at least one anionic polysaccharide.

Priority: US1998-175942 Applic. Date: 1998-10-21

Inventor: WANG TIAN XIANG [US]; DIGIROLAMO DEBRA MARSHA VERDON [US]; RUSS JULIO GANS [US]


Patent No.: US6197338B1  Issued: 06/Mar/2001

Title: Effervescent bath tablet, method of preparing it, and the use thereof

Applicant/Assignee: MERZ & CO. GMBH & CO

Application No.: 09/481912   Filing Date: 12/Jan/2000

Abstract:

The present invention relates to a new type of solid balneological preparations for cosmetic, hygienic and therapeutic use, which has both the properties of a solid bath additive and those of liquid products, and is characterized especially by the addition of lipid components, vesicle forming lipids, tensides and, in some cases, mineral salts. Active components, adjuvants such as stabilizers, adsorbing substances, lubricants as well as smoothing and breakdown promoting agents may also be contained therein.

Priority: DE19971057059 Applic. Date: 1997-12-20; US1998-114796 Applic. Date: 1998-07-13

Inventor: NUERNBERG EBERHARD [DE]; JERZEMBEK KERSTIN [DE]; BEUTLER ROLF D [DE]; EBINGER JUERGEN [DE]; WEIS RUTH [DE]


Patent No.: US6197511B1  Issued: 06/Mar/2001

Title: Human kallikrein

Applicant/Assignee: INCYTE GENOMICS, INC

Application No.: 09/210084   Filing Date: 11/Dec/1998

Abstract:

The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKAL,. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.

Priority: US1997-824874 Applic. Date: 1997-03-26

Inventor: HILLMAN JENNIFER L [US]; LAL PREETI [US]


Patent No.: US6197757B1  Issued: 06/Mar/2001

Title: Particles, especially microparticles or nanoparticles, of crosslinked monosaccharides and oligosaccharides, processes for their preparation and cosmetic, pharmaceutical or food compositions in which they are present

Applicant/Assignee:

Application No.: 09/350131   Filing Date: 09/Jul/1999

Abstract:

Particles comprising an outer wall formed of one or more saccharide components selected from the group consisting of monosaccharides and oligosaccharides crosslinked by interfacial crosslinking in emulsion, preferably at room temperature, with a polyfunctional acylating crosslinking agent to produce ester linkages between the acylatable hydroxyl group(s) of the primary alcohol(s) of the saccharide component and the acyl groups of the polyfunctional acylating agent. These particles can be used for the manufacture of cosmetic, pharmaceutical and food compositions.

Priority: FR19980008809 Applic. Date: 1998-07-09

Inventor: PERRIER ERIC [FR]; REY-GOUTENOIRE SYLVIE [FR]; BUFFEVANT CHANTAL [FR]; LEVY MARIE-CHRISTINE [FR]; PARIOT NADINE [FR]; EDWARDS FLORENCE [FR]; ANDRY MARIE-CHRISTINE [FR]


Patent No.: US6200552B1  Issued: 13/Mar/2001

Title: Photostabilized sunscreen compositions comprising dibenzoylmethane compounds

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/350910   Filing Date: 12/Jul/1999

Abstract:

Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective amount of at least one dibenzoylmethane UV-screening compound, and (ii) an amount of at least one silane or organosiloxane substituted by a benzylidenecamphor functional group effective to photostabilize said at least one dibenzoylmethane UV-screening compound (i).

Priority: FR19980008937 Applic. Date: 1998-07-10

Inventor: RICHARD HERVE [FR]; FORESTIER SERGE [FR]


Patent No.: US6200579B1  Issued: 13/Mar/2001

Title: Use of a two-phase composition for make-up removal of transfer-free make-up compositions

Applicant/Assignee: L'OREAL

Application No.: 08/921333   Filing Date: 29/Aug/1997

Abstract:

An applied make-up of long durability and/or a transfer-free make-up composition is removed from the skin by applying to the skin a composition consisting of an aqueous phase and an oily phase, which are distinct, to remove the make-up or transfer-free make-up.

Priority: FR19960010923 Applic. Date: 1996-09-06

Inventor: PICARD ELISABETH [FR]


Patent No.: US6200581B1  Issued: 13/Mar/2001

Title: Elastomeric silicone terpolymer

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/299864   Filing Date: 28/Apr/1999

Abstract:

Three-dimensional silicone elastomers having both polyether and higher alkyl functionality present in their molecules are in the form of networks of crosslinked linear siloxanes with polyether and olefin containing repeating units. Representative units are EO7 and EO12 for the polyether functionality, and C10, C12, and C18 alkyl functionality for the olefin. These gelled molecules are multipurpose type materials, and consequently they are capable of being useful in a variety of multiphased formulations in personal and health care applications.

Priority:

Inventor: LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]; SMITH JANET MARY [US]


Patent No.: US6203802B1  Issued: 20/Mar/2001

Title: Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by topical application to the skin, and corresponding preparation process

Applicant/Assignee: L'OREAL

Application No.: 08/195081   Filing Date: 14/Feb/1994

Abstract:

Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper layers of the epidermis. The nanoparticles are preferably prepared from a polymer of (C2-C12) alkyl cyanoacrylate.

Priority: FR19900003418 Applic. Date: 1990-03-16; US1992-961537 Applic. Date: 1992-10-15; US1991-668308 Applic. Date: 1991-03-13

Inventor: HANDJANI ROSE-MARIE [FR]; RIBIER ALAIN [FR]


Patent No.: US6203803B1  Issued: 20/Mar/2001

Title: Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 08/881272   Filing Date: 24/Jun/1997

Abstract:

The invention concerns the use of a substance P antagonist in a cosmetic composition used to treat sensitive skin. More specifically, the invention relates to a substance P antagonist used to prevent and/or combat skin irritations, desquamation, erythemas, sensations of dysesthesia/overheating, or pruritus of the skin.

Priority: US1994-358562 Applic. Date: 1994-12-14

Inventor: DE LACHARRIERE OLIVIER [FR]; BRETON LIONEL [FR]


Patent No.: US6203808B1  Issued: 20/Mar/2001

Title: Ceramide compounds, process of preparation and use

Applicant/Assignee: L'OREAL

Application No.: 09/467875   Filing Date: 21/Dec/1999

Abstract:

The present application relates to novel ceramide compounds to their process of preparation and to their use in cosmetics or in pharmaceuticals, in particular for treating and caring for the skin, hair, nails and eyelashes.

Priority: FR19970013844 Applic. Date: 1997-11-04; US1998-185628 Applic. Date: 1998-11-04

Inventor: TULOUP REMY [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6207175B1  Issued: 27/Mar/2001

Title: Powdered cosmetic and/or dermatological lotion and its use

Applicant/Assignee: L'OREAL

Application No.: 09/428986   Filing Date: 29/Oct/1999

Abstract:

A cosmetic and/or dermatological lotion comprising an aqueous phase and a powdered phase, the powdered phase comprising at least one active powder and hollow particles based on at least one acrylic or methacrylic polymer or copolymer, the aqueous phase being present in an amount ranging from 90 to 99.99% by weight with respect to the total weight of the lotion. The inventive lotion has the advantage of being soft on application and of exhibiting a powdered phase which does not become clogged. The lotion may be used for caring for, cleaning, removing make-up from and/or coloring the skin, mucous membranes and/or scalp.

Priority: FR19980013867 Applic. Date: 1998-11-04

Inventor: LEBRETON FRANCOISE [FR]


Patent No.: US6207184B1  Issued: 27/Mar/2001

Title: Hydrophilic adhesive masses

Applicant/Assignee: SSP CO., LTD

Application No.: 09/330065   Filing Date: 11/Jun/1999

Abstract:

A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.

Priority: JP19980171103 Applic. Date: 1998-06-18

Inventor: IKEDA YASUO [JP]; OKUYAMA HIROHISA [JP]; ISHIGAKI KENJI [JP]; KASAI SHUICHI [JP]; IMAMORI KATSUMI [JP]


Patent No.: US6207400B1  Issued: 27/Mar/2001

Title: Non- or minimally invasive monitoring methods using particle delivery methods

Applicant/Assignee: POWDERJECT RESEARCH LIMITED

Application No.: 09/390068   Filing Date: 03/Sep/1999

Abstract:

Methods for sampling an analyte present in a biological system are provided. The methods entail use of particle delivery methods to obtain a sample of an analyte of interest from the system.

Priority: US19980099157P Applic. Date: 1998-09-04

Inventor: KWON SUNG-YUN [US]


Patent No.: US6207778B1  Issued: 27/Mar/2001

Title: Conditioning/styling terpolymers

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 09/307211   Filing Date: 07/May/1999

Abstract:

What is described herein are conditioning/styling terpolymers of vinylpyrrolidone (VP), dimethylaminopropyl methacrylamide (DMAPMA) and C9-C24 alkyl dimethylaminopropyl methacrylic acid quaternized monomers (QDMAPMA), in a defined compositional range. Hair and skin care compositions which include these terpolymers exhibit advantageous low tackiness and high humidity resistance.

Priority:

Inventor: JACHOWICZ JANUSZ [US]; LIU KOU-CHANG [US]; MC MULLEN JR ROGER L [US]; WINKLER THOMAS [US]


Patent No.: US6210656B1  Issued: 03/Apr/2001

Title: Self-foaming cream

Applicant/Assignee: L'OREAL

Application No.: 09/292372   Filing Date: 15/Apr/1999

Abstract:

A self-foaming composition in the form of a post-foaming, pressurizable oil-in-water emulsion comprising:(A) at least 5% by weight, relative to the total weight of the composition, of a fatty phase comprising at least one cosmetic oil,(B) a gelling system comprising at least one emulsifying polymer which is selected from the group consisting of:(1) crosslinked homopolymers formed from at least one cationic or anionic monomer containing ethylenic unsaturation selected from the group consisting of ammonium (meth)acrylate

2-acrylamido-2-methylpropanesulfonic acid as well as its salts, dialkylaminoalkyl (meth)acrylates, dialkylaminoalkyl (meth)acrylamide and its quaternary salts or acids, wherein the crosslinking agent which forms the crosslinking contains ethylenic polyunsaturation, and(2) crosslinked copolymers formed from at least one cationic or anionic monomer containing ethylenic unsaturation, from at least one nonionic comonomer and from a crosslinking agent containing ethylenic polyunsaturation

and(C) water.

Priority: FR19960012510 Applic. Date: 1996-10-14; US1997-949684 Applic. Date: 1997-10-14

Inventor: TOUZAN PHILIPPE [FR]; DELAMBRE PATRICIA [FR]


Patent No.: US6210695B1  Issued: 03/Apr/2001

Title: Leave-on antimicrobial compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/869129   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5.0%, by weight of the leave-on antimicrobial composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the leave-on antimicrobial composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the leave-on antimicrobial composition, of a proton donating agent

and from about 0% to about 99.85%, by weight of the leave-on antimicrobial composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for moisturizing, reducing the number of germs on the skin, and decreasing the spread of transient Gram negative and Gram positive bacteria using the leave-on antimicrobial compositions described herein.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BAKKEN THERESA ANNE [US]; EVANS MARCUS WAYNE [US]


Patent No.: US6211250B1  Issued: 03/Apr/2001

Title: Percutaneous delivery system

Applicant/Assignee: SOLTEC RESEARCH PTY LTD

Application No.: 09/308574   Filing Date: 21/May/1999

Abstract:

The invention relates to a substantially homogenous liquid composition capable of percutaneous delivery of one or more physiologically active agents, the composition including a rate modulating polymer, a volatile solvent and at least one physiologically active agent, said rate modulating polymer being selected to enable modulation of the rate of delivery of said physiologically active agent. Methods of percutaneous delivery of active agents and of prophylactic or therapeutic antimicrobial, antifungal or antiviral treatment using the compositions of the invention are also described.

Priority: AU1996PO03795 Applic. Date: 1996-11-22; WO1997AU00797 Applic. Date: 1997-11-24

Inventor: TOMLINSON ROD [AU]; DAVEY GREG [AU]


Patent No.: US6214322B1  Issued: 10/Apr/2001

Title: Self-tanning composition comprising carmine

Applicant/Assignee: NEUTROGENA CORPORATION

Application No.: 09/333446   Filing Date: 15/Jun/1999

Abstract:

The present invention relates to a composition comprising self-tanning agent and carmine, cosmetic products comprising such composition and a cosmetically acceptable carrier, and methods of using such products.

Priority:

Inventor: CASTRO MAURICIO [US]; WOODIN JR FREDERICK W [US]


Patent No.: US6214323B1  Issued: 10/Apr/2001

Title: Photoprotective/cosmetic compositions comprising camphorsulfonic acid, bisresorcinyltriazine and benzoazolyl/benzodiazolyl sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/503169   Filing Date: 14/Feb/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) benzene-1,4-bis(3-methylidene-10-camphorsulfonic acid), optionally in neutralized form thereof, (b) at least one bisresorcinyltriazine compound, and (c) at least one compound containing at least two benzoazolyl groups or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990001733 Applic. Date: 1999-02-12

Inventor: CANDAU DIDIER [FR]


Patent No.: US6214324B1  Issued: 10/Apr/2001

Title: Photoprotective/cosmetic compositions comprising benzotriazole and benzoazolyl/benzodiazolyl sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/503941   Filing Date: 14/Feb/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one benzotriazole compound, and (b) at least one compound containing at least two benzoazolyl groups and/or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefore.

Priority: FR19990001728 Applic. Date: 1999-02-12

Inventor: CANDAU DIDIER [FR]


Patent No.: US6214361B1  Issued: 10/Apr/2001

Title: Process for the extraction of an active principle from tournesol, active principle obtained, and composition active against aging of the skin

Applicant/Assignee: S.A. SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE (SILAB)

Application No.: 09/482886   Filing Date: 14/Jan/2000

Abstract:

The object of the invention covers an extraction process for an active principle having anti-radical and anti-glycolation action to counter cutaneous aging. The invention also covers the obtained active principle, the cosmetic compositions using this active principle, and a process for countering aging.

Priority: FR19990016099 Applic. Date: 1999-12-16

Inventor: PAUFIQUE JEAN-JACQUES [FR]


Patent No.: US6214363B1  Issued: 10/Apr/2001

Title: Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/969077   Filing Date: 12/Nov/1997

Abstract:

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent

from about 0.1% to about 30% of a deposition aid

and from about 3% to about 98.8% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BARTOLO ROBERT GREGORY [US]; BAKKEN THERESA ANNE [US]; CARETHERS MARY ELIZABETH [US]; SINE MARK RICHARD [US]; CLAPP MANNIE LEE [US]; WARREN RAPHAEL [US]


Patent No.: US6214873B1  Issued: 10/Apr/2001

Title: 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same

Applicant/Assignee: WELFIDE CORPORATION

Application No.: 09/402375   Filing Date: 05/Jan/2000

Abstract:

The present invention relates to a compound of the general formulawherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof

a pharmaceutical comprising this compound

a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier

and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

Priority: JP19970086255 Applic. Date: 1997-04-04; WO1998JP01571 Applic. Date: 1998-04-03

Inventor: ADACHI KUNITOMO [JP]; AOKI YOSHIYUKI [JP]; HANANO TOKUSHI [JP]; TESHIMA KOJI [JP]; HOSHINO YUKIO [JP]; FUJITA TETSURO [JP]


Patent No.: US6216707B1  Issued: 17/Apr/2001

Title: Use of at least an Irvingia gabonensis extract in a cosmetic and/or pharmaceutical product

Applicant/Assignee: LABORATOIRES SEROBIOLOGIQUES SOCIETE ANONYME

Application No.: 09/402834   Filing Date: 13/Oct/1999

Abstract:

The use of at least an Irvingia gabonensis extract, in particular Irvingia gabonensis seeds, as active agent(s) for preparing a cosmetic and/or pharmaceutical product for topical use on the skin and/or superficial body growth, the extract being present between 0.05% and 50.00% by weight.

Priority: FR19970004732 Applic. Date: 1997-04-14; WO1998FR00538 Applic. Date: 1998-03-17

Inventor: PAULY GILLES [FR]


Patent No.: US6217854B1  Issued: 17/Apr/2001

Title: Cosmetic effervescent cleansing pillow

Applicant/Assignee: CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC

Application No.: 09/532767   Filing Date: 22/Mar/2000

Abstract:

A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.

Priority: US1998-130981 Applic. Date: 1998-08-07

Inventor: FARRELL LINDA [US]; SLAVTCHEFF CRAIG STEPHEN [US]; ZNAIDEN ALEXANDER PAUL [US]; VINSKI PAUL [US]


Patent No.: US6217876B1  Issued: 17/Apr/2001

Title: Cosmetic, dermatological and pharmaceutical use of an extract of Terminalia catappa

Applicant/Assignee: LABORATOIRES SEROBIOLOGIQUES (SOCIETE ANONYME)

Application No.: 09/268700   Filing Date: 16/Mar/1999

Abstract:

The invention concerns the use of an extract of the Terminalia catappa plant, as well as cosmetic, dermatological and pharmaceutical compositions containing such an extract. The invention also concerns the use of an extract of the Terminalia catappa plant with other active compounds, in a cosmetic, dermatological and/or pharmaceutical composition for external topical use for the skin or superficial body growth.

Priority: FR19960011403 Applic. Date: 1996-09-16; WO1997FR01468 Applic. Date: 1997-08-07

Inventor: PAULY GILLES [FR]


Patent No.: US6217885B1  Issued: 17/Apr/2001

Title: Antipruriginous cosmetic and/or pharmaceutical compositions consisting of one or several light local anaesthetics and one or several astringent substances

Applicant/Assignee: BAYER AKTIENGESELLSCHAFT

Application No.: 09/029114   Filing Date: 18/Feb/1998

Abstract:

The present invention relates to antipruritic cosmetic and/or pharmaceutical compositions for use on human or animal skin, comprising one or more mild local anesthetics, one or more astringents and/or, if appropriate, a substance having an antiinflammatory action.

Priority: DE19951031893 Applic. Date: 1995-08-30; WO1996EP03641 Applic. Date: 1996-08-19

Inventor: ROEDER KLAUS [DE]; KOCH SABINE [DE]


Patent No.: US6217887B1  Issued: 17/Apr/2001

Title: Leave-on antimicrobial compositions which provide improved immediate germ reduction

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/323531   Filing Date: 01/Jun/1999

Abstract:

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active

from about 0.5% to about 10% of an anionic surfactant

from about 0.1% to about 10% of a proton donating agent, wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid

and from about 0% to about 98.85% of water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the leave-on antimicrobial composition has a One-wash Immediate Germ Reduction Index of greater than about 50%

and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for moisturizing skin, reducing germs on the skin, and providing residual effectiveness versus Gram positive bacteria using these products.

Priority: US1997-869303 Applic. Date: 1997-06-04

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BAKKEN SCHUETTE THERESA ANNE [US]; CHEN RAYMOND WEI [US]


Patent No.: US6217888B1  Issued: 17/Apr/2001

Title: Methods of regulating skin appearance with vitamin B3 compound

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/328578   Filing Date: 09/Jun/1999

Abstract:

The present invention relates to topical compositions comprising a vitamin B3 compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

Priority: US1997-834010 Applic. Date: 1997-04-11; US1995-554067 Applic. Date: 1995-11-06; US19960028902P Applic. Date: 1996-10-21; US19960025242P Applic. Date: 1996-09-16; US19960016043P Applic. Date: 1996-04-23

Inventor: OBLONG JOHN ERICH [US]; BISSETT DONALD LYNN [US]; BIEDERMANN KIMBERLY ANN [US]


Patent No.: US6217889B1  Issued: 17/Apr/2001

Title: Personal care articles

Applicant/Assignee: THE PROCTOR & GAMBLE COMPANY

Application No.: 09/443741   Filing Date: 19/Nov/1999

Abstract:

The present invention relates to a substantially dry, disposable personal care article suitable for cleansing, said article comprising:a) a water insoluble substrate comprising a creped nonwoven layer wherein said layer has a Crepe Ratio of from about 4.5 to about 45

andb) a cleansing component disposed adjacent to said creped nonwoven layer, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant.The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit component in addition to or in lieu of the cleansing component.These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invention further relates to methods of cleansing and/or conditioning the skin and hair utilizing the articles of the present invention.

Priority: US19990146747P Applic. Date: 1999-08-02

Inventor: LORENZI MARC PAUL [GB]; SMITH III EDWARD DEWEY [US]


Patent No.: US6218432B1  Issued: 17/Apr/2001

Title: Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them

Applicant/Assignee: L'OREAL

Application No.: 09/297748   Filing Date: 14/Jul/1999

Abstract:

Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I):or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.

Priority: FR19970011174 Applic. Date: 1997-09-09; WO1998FR01877 Applic. Date: 1998-09-01

Inventor: GALEY JEAN-BAPTISTE [FR]; DUMATS JACQUELINE [FR]


Patent No.: US6218443B1  Issued: 17/Apr/2001

Title: Pentafluoropropane blowing agent-containing resin blend for use in making integral skin foams

Applicant/Assignee: BASF CORPORATION

Application No.: 09/000770   Filing Date: 30/Dec/1997

Abstract:

It has been found that non-chlorinated pentafluoropropane blowing agents may be used alone or in combination with water in flexible integral skin foams. For example, foams prepared from a resin blend incorporating 1,1,1,3,3-pentafluoropropane (HFA-245fa) alone or in combination with water exhibit physical characteristics such as resistance to abrasion and cracking on flex comparable to conventional chlorinated fluorocarbon blown foams. Such foams made using the resin blend of the present invention are suitable for use in many applications including, for example, shoe soles.

Priority:

Inventor: VALOPPI VALERI L [US]; BREDESON ELIZABETH S [US]


Patent No.: US6221343B1  Issued: 24/Apr/2001

Title: Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/503943   Filing Date: 14/Feb/2000

Abstract:

Novel liposoluble and photostable N-substituted benzimidazole/benzofuryl-benzazole silicon-containing compounds are conspicuously excellent UV-absorbers and are conveniently formulated, e.g., into topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair.

Priority: FR19990001734 Applic. Date: 1999-02-12

Inventor: RICHARD HERVE [FR]; LUPPI BERNADETTE [FR]


Patent No.: US6221345B1  Issued: 24/Apr/2001

Title: Cosmetic composition

Applicant/Assignee: HELENE CURTIS, INC

Application No.: 08/880075   Filing Date: 20/Jun/1997

Abstract:

An antiperspirant or deodorant cosmetic composition suitable for topical application to the human skin, comprising:i. an antiperspirant or deodorant active

ii. a moisturising cream

and optionallyiii. a carrier for the antiperspirant or deodorant active.

Priority: GB19960012945 Applic. Date: 1996-06-20; GB19960026793 Applic. Date: 1996-12-23; GB19960026794 Applic. Date: 1996-12-23

Inventor: ESSER ISABELLE CLAIRE HELENE M [GB]


Patent No.: US6221372B1  Issued: 24/Apr/2001

Title: Cosmetic cleansing and skin care preparation containing plant and algae extracts

Applicant/Assignee: LANCASTER GROUP GMBH

Application No.: 09/319090   Filing Date: 28/May/1999

Abstract:

The invention relates to a cosmetic cleansing and skin care preparation which is particularly suitable for extremely greasy pubertal skin and exhibits very good sebostatic effectiveness. The preparation contains 0.25-5 wt. % of a combination comprising 5-40 wt. % of an alga laminaria saccharina extract

10-60 wt. % of lilium candidum root extract

10-50 wt. % glycyrrehetinic acid as a natural extract of glycyrrhiza glabra. The preparation also contains 99.75 to 95 wt. % cosmetic auxiliary agents and carriers, optionally mixed with additional active substances.

Priority: DE19961054508 Applic. Date: 1996-12-18; WO1997DE02935 Applic. Date: 1997-12-12

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Patent No.: US6221927B1  Issued: 24/Apr/2001

Title: Polar solvent-in-oil emulsions and multiple emulsions

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/657555   Filing Date: 08/Sep/2000

Abstract:

One composition is a non-aqueous polar solvent-in-oil emulsion containing a non-aqueous polar solvent phase dispersed in a silicone oil continuous phase by an emulsifier. A second composition is a non-aqueous polar solvent-in-oil-in-water multiple emulsion of the type PS1/O/W which contains a non-aqueous polar solvent phase PS1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS1/O by an emulsifier. The primary emulsion PS1/O is dispersed in a second continuous aqueous phase W to form multiple emulsion PS1/O/W. A third composition is a non-aqueous polar solvent-in-oil-in-non-aqueous polar solvent multiple emulsion of the type PS1/O/PS2 which contains a non-aqueous polar solvent phase PS1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS1/O by an emulsifier. The primary emulsion PS1/O is dispersed in a second continuous non-aqueous polar solvent phase PS2 to form multiple emulsion PS1/O/PS2.

Priority: US2000-498714 Applic. Date: 2000-02-07; US1999-435561 Applic. Date: 1999-11-08

Inventor: LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]; SMITH JANET MARY [US]


Patent No.: US6224850B1  Issued: 01/May/2001

Title: Antiwrinkle cosmetic/pharmaceutical compositions comprising iridaceae extracts

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 08/826424   Filing Date: 27/Mar/1997

Abstract:

Cosmetic/pharmaceutical compositions, well suited for the treatment of unwanted skin wrinkles, e.g., for visibly reducing human skin wrinkles, comprise an effective antiwrinkle amount of at least one extract of at least one member of the Iridaceae family that relaxes and/or loosens cutaneous and/or subcutaneous tissue, formulated into a cosmetically/pharmaceutically acceptable excipient or carrier therefor.

Priority: FR19960003817 Applic. Date: 1996-03-27

Inventor: BRETON LIONEL [FR]; DE LACHARRIERE OLIVER [FR]; MARTIN RICHARD [FR]


Patent No.: US6224853B1  Issued: 01/May/2001

Title: Aqueous compositions comprising a lipid and a lanolin-derived surfactant, and their use

Applicant/Assignee: WOOLCOMBERS GROUP PLC

Application No.: 09/403526   Filing Date: 01/Feb/2000

Abstract:

An aqueous composition comprising, in addition to water: (a) one or more surfactant materials selected from polyoxyalkylene condensate derivatives of lanolin or a lanolin derivative

and (b) a lipid component comprising one or more lipid materials, especially lanolin or a lanolin derivative, present as particles emulsified by the said one or more lanolin-derived surfactant materials and having a median particle size of less than about 5 mum, especially from 0.01 to 1 mum. The compositions have very good physical stability and are particularly useful as carriers for transdermal delivery of pharmaceutical actives to the human skin.

Priority: GB19970008066 Applic. Date: 1997-04-22; WO1998GB01174 Applic. Date: 1998-04-22

Inventor: STEEL IAN [GB]; KITCHEN GUY STANLEY HAWKSWORTH [GB]; FLOCKHART IAN RONALD [GB]


Patent No.: US6224854B1  Issued: 01/May/2001

Title: UV protection compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/510831   Filing Date: 23/Feb/2000

Abstract:

The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The composing provide excellent efficiency, broad spectrum UV efficacy, and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise:a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active

b) an effective amount of a styrene derivative, having the formula wherein at least one of R1, R2, and R3 is an electron-withdrawing substituent, provided that R1 is other than an aryl or a methyl, that R2 and R3 are each other than a ketone, and that R2 and R3 together do not form a camphor group

wherein the remaining substituents of R1, R2, and R3 that are not electron-withdrawing substituents are selected from the group consisting of H and electron-donating substituents

and wherein R4 is selected from the group consisting of H, electron-donating substituents other than ethers, and electron-withdrawing substituents other than cyanos

andc) a suitable carrier.

Priority: US1999-263013 Applic. Date: 1999-03-05; US1998-174177 Applic. Date: 1998-10-16

Inventor: ROBINSON LARRY RICHARD [US]


Patent No.: US6224889B1  Issued: 01/May/2001

Title: Active composition for combating the effects of the cold and cosmetic product containing this composition

Applicant/Assignee: LABORATOIRES SEROBIOLOGIQUES (SOCIETE ANONYME)

Application No.: 09/367224   Filing Date: 08/Sep/1999

Abstract:

Topical active composition against the effects of cold, which is constituted by 0.1% to 30% by weight of polysaccharides comprising at least glycogen and at least one mucilage extracted from conifer, by 45% to 95% by weight of vegetable proteins extracted from legumes and by 0.1% to 25% by weight of amino acids selected from the group consisting of threonine, serine, proline and alanine.

Priority: FR19970001711 Applic. Date: 1997-02-11; WO1998FR00180 Applic. Date: 1998-01-30

Inventor: PAULY GILLES [FR]


Patent No.: US6224893B1  Issued: 01/May/2001

Title: Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY UNIVERSITY TECHNOLOGY CORPORATION THE GENERAL HOSPITAL HOSPITAL CORPORATION

Application No.: 08/862740   Filing Date: 23/May/1997

Abstract:

Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other

semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs.As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous souce of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

Priority: US19970041881P Applic. Date: 1997-04-11

Inventor: LANGER ROBERT S [US]; ELISSEEFF JENNIFER H [US]; ANSETH KRISTI [US]; SIMS DEREK [US]


Patent No.: US6225299B1  Issued: 01/May/2001

Title: Hormonal agent for skin treatment

Applicant/Assignee: JENAPHARM GMBH & CO. KG

Application No.: 09/219660   Filing Date: 23/Dec/1998

Abstract:

The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a combination of dienogest and an estrogen, as active ingredient. Methods for treatment of this type of skin condition include topical application of the composition including the dienogest which results in an outstanding sebosuppression, a drastic reduction of androstandiol glucuronide and a moderate competitive blockage of androgen receptor sites. Galenic formulations are described which limit and/or prevent the permeation of the active ingredient through the skin. The pharmaceutical preparation including the dienogest and conventional dermatologically acceptable carrier and auxiliary substances in the described galenic formulation advantageously provides a drastic reduction in androstandiol glucuronide and moderate androgen receptor blockage without passing through the skin barrier so that systemic effects including side reactions are substantially prevented.

Priority: US1996-714463 Applic. Date: 1996-09-16

Inventor: GOLBS SIEGFRIED [DE]; OETTEL MICHAEL [DE]; DITTGEN MICHAEL [DE]; GRASER THOMAS [DE]; LUDERSCHMIDT CHRISTOPH [DE]


Patent No.: US6225521B1  Issued: 01/May/2001

Title: Adhesive-matrix patch

Applicant/Assignee: L'OREAL

Application No.: 09/272241   Filing Date: 19/Mar/1999

Abstract:

The invention relates to a patch comprising a matrix made of a material having self-adhesive properties to being applied to the skin. The patch includes a permeable structure completely embedded in said matrix close to its surface so as to modify the overall adhesive power thereof.

Priority: FR19980003589 Applic. Date: 1998-03-24

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6228117B1  Issued: 08/May/2001

Title: Device for tissue engineering bone

Applicant/Assignee: ISOTIS B.V

Application No.: 09/116177   Filing Date: 15/Jul/1998

Abstract:

A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolyester consists essentially of a multiplicity of recurring long-chain ester units and short-chain ester units, the long-chain ester units comprising from 35 to 80% by weight of the copolyester and being represented by the formulaand the short-chain ester units being represented by the formulawhereinL is a divalent group remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol with an average molecular weight of between 300 and 3000

R is a divalent group remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300

Q is an alkylene group having 1-6 carbon atoms and/or a cyclohexylene of phenylene group

andE is an alkylene group having 2-6 carbon atoms.

Priority: EP19970202214 Applic. Date: 1997-07-16

Inventor: DE BRUIJN JOOST DICK [NL]; BOVELL YVONNE PEARL [NL]; VAN DEN BRINK JENNIGJE [NL]; VAN BLITTERSWIJK CLEMENS ANTON [NL]


Patent No.: US6228348B1  Issued: 08/May/2001

Title: Composition in the form of an oil-in-water emulsion comprising an acrylic terpolymer and its uses, in particular its cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/503196   Filing Date: 14/Feb/2000

Abstract:

A composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase and comprising at least one acrylic terpolymer obtained from the polymerization of a carboxylic acid monomer having alpha,beta-ethylenic unsaturation, a non-surface-active monomer comprising ethylenic unsaturation other than (a), and a non-ionic urethane monomer which is the reaction product of a monohydric non-ionic amphiphilic compound with an isocyanate comprising monoethylenic unsaturation, in which the terpolymer/oily phase ratio by weight ranges from 1/50 to 1/125. The composition is particularly suited for cosmetic and/or dermatological applications.

Priority: FR19990003320 Applic. Date: 1999-03-17

Inventor: SIMON PASCAL [FR]; BORDEAUX DOMINIQUE [FR]


Patent No.: US6228350B1  Issued: 08/May/2001

Title: Method of depigmenting and/or bleaching skin and/or body hair or head hair

Applicant/Assignee: L'OREAL

Application No.: 09/489840   Filing Date: 24/Jan/2000

Abstract:

The use, in a topical cosmetic composition, or for the manufacture of a topical dermatological composition, intended for depigmenting and/or bleaching human skin, body hair or head hair, of at least one compound comprising a phenyloxime fragment.

Priority: FR19990000882 Applic. Date: 1999-01-27

Inventor: TULOUP REMY [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6228377B1  Issued: 08/May/2001

Title: Water-in-oil emulsion containing fused silica and a polysaccharide alkyl ether

Applicant/Assignee: L'OREAL

Application No.: 09/141332   Filing Date: 27/Aug/1998

Abstract:

A water-in-oil emulsion is provided having a liquid fatty phase and an aqueous phase, wherein the liquid fatty phase contains a fumed silica and at least one polysaccharide alkyl ether formed of units containing at least two different saccharide rings, each unit containing at least one hydroxyl group substituted with a hydrocarbon-based chain, and from 0% to 5% by weight, relative to the total weight of the emulsion, of at least one emulsifying surfactant, and the liquid fatty phase contains at least one medium which is a solvent for the polysaccharide alkyl ether, that is useful in particular in the cosmetics and/or dermatological fields.

Priority: FR19970010756 Applic. Date: 1997-08-28

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]


Patent No.: US6231837B1  Issued: 15/May/2001

Title: Self-tanning dihydroxyacetone formulations having improved stability and providing enhanced delivery

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 09/552437   Filing Date: 18/Apr/2000

Abstract:

A composition is provided which is useful for self-tanning skin coloring and is characterized by improved stability, which comprises from about 0.5% to about 20.0% by weight, based on total weight of said composition, of a self-tanning skin coloring agent subject to chemical instability, which is preferably dihydroxyacetone

from about 2.0% to about 40.0% by weight of a polyethoxyglycol, which is preferably ethoxydiglycol

and from about 0.1% to about 15.0% by weight of a polyol comprising a polyhydric compound having at least three hydroxyl groups and at least three carbon atoms, which is preferably D-sorbitol. The self-tanning composition may further optionally contain from about 0.1% to about 8.0% by weight of a water soluble dihydroxyl compound having at least two, and up to eight carbon atoms, which is preferably ethylene glycol

and the self-tanning composition may still further optionally contain an acidifying agent in amount sufficient to maintain the pH of said total composition at from about 3.5 to about 4.5, which is preferably sorbic acid. Cosmetologic products and methods of tanning are also provided.

Priority: US1998-092340 Applic. Date: 1998-06-05; US19970048903P Applic. Date: 1997-06-06

Inventor: STROUD ERIC M [US]; SCOTT JOHN A [US]


Patent No.: US6231841B1  Issued: 15/May/2001

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/547625   Filing Date: 12/Apr/2000

Abstract:

Antiperspirant compositions herein comprise an antiperspirant active, a carrier and a structurant for the carrier which comprises an effective concentration of a combination of at least one sterol and at least one sterol ester, to form a solid or a soft solid. The compositions can be anhydrous and in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions.A particularly suitable sterol comprises beta sitosterol and a particularly preferred sterol ester comprises oryzanol. Preferably the mole ratio of sterol to sterol ester is in the range of 3:1 to 1:2.

Priority: GB19990008208 Applic. Date: 1999-04-12

Inventor: FRANKLIN KEVIN RONALD [GB]; GRAINGER LYNDA [GB]; KOWALSKI ADAM JAN [GB]


Patent No.: US6231848B1  Issued: 15/May/2001

Title: Topical Products as prophylactic of curative agents for bacterial skin infections

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 09/269333   Filing Date: 25/Mar/1999

Abstract:

The present invention relates to topical products intended for use as prophylactic or curative agents for bacterial skin infections, containing at least one polymeric complex substantially consisting of hydrogen peroxide, a suitable polymer for the complex formation thereof, possibly another bactericidal compound and possibly a metal salt or a metal colloid.

Priority: DE19961040364 Applic. Date: 1996-09-30; WO1997EP05291 Applic. Date: 1997-09-26

Inventor: BREITENBACH JOERG [DE]; FUSSNEGGER BERNHARD [DE]; LANG SIEGFRIED [DE]


Patent No.: US6231874B1  Issued: 15/May/2001

Title: Structured water for enhanced moisturization

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 09/042345   Filing Date: 13/Mar/1998

Abstract:

The invention relates to a cosmetic or pharmaceutical composition containing a moisturizing effective amount of S water, as well as a method for enhancing the moisturization capacity of a skin care composition containing an aqueous component comprising incorporating S water as all or part of the aqueous component

Priority:

Inventor: CIOCA GHEORGHE [US]; BEVACQUA ANDREW J [US]; GUBERNICK JOSEPH [US]; VRABIE NICOLAE [US]


Patent No.: US6231875B1  Issued: 15/May/2001

Title: Acidified composition for topical treatment of nail and skin conditions

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 09/265284   Filing Date: 09/Mar/1999

Abstract:

This invention relates to a method for topical treatment of human nail and skin diseases, including fungal infections, bacterial infections, and psoriatic infections. In addition, this invention relates to a method of treating the general condition of human nails including their strength, rate of growth and appearance. More particularly, the invention relates to an acidified composition and methods of using said composition. Still further the invention relates to an acidified lacquer useful in treating human nails and skin.

Priority: US19980080116P Applic. Date: 1998-03-31

Inventor: SUN YING [US]; LIU JUE-CHEN [US]; KIMBLETON ELIZABETH [US]; WANG JONAS C T [US]


Patent No.: US6231876B1  Issued: 15/May/2001

Title: Use of water-soluble copolymers as active ingredients in cosmetics

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 09/269337   Filing Date: 25/Mar/1999

Abstract:

A cosmetic composition comprising water-soluble copolymer, which as characteristic structural elements comprisesa) vinylcarboxamide units of the general formula IwhereR1 and R2 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, andb) units of the general formula IIwhereA is a chemical bond or an alkylene group,the radicals R3 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, or together with the nitrogen atom to which they are bonded, form an unsubstituted, mono- or polysubstituted, five- to seven-membered, heterocyclic, aromatic or nonaromatic ring, which if appropriate contains one or two further heteroatoms, selected from among O, N and S, it being possible for the heterocyclic ring to be fused to a further five- or six-membered, aromatic or nonaromatic ring,R4 is H, alkyl or aralkyl.

Priority: DE19961040363 Applic. Date: 1996-09-30; WO1997EP05354 Applic. Date: 1997-09-29

Inventor: NIESSNER MANFRED [DE]; NILZ CLAUDIA [DE]; HOESSEL PETER [DE]; KOTHRADE STEPHAN [DE]; SANNER AXEL [DE]


Patent No.: US6232688B1  Issued: 15/May/2001

Title: High speed magnetic thrust disk

Applicant/Assignee: ALLISON ADVANCED DEVELOPMENT COMPANY ROLLS-ROYCE CORPORATION

Application No.: 09/301302   Filing Date: 28/Apr/1999

Abstract:

The present invention contemplates an internally reinforced high-speed magnetic thrust disk. In one embodiment the internally reinforced composite thrust disk comprises a plurality of high strength fibers coupled together by a soft magnetic alloy. Further, in one aspect the disk having internally reinforced zones for controlling bore growth and counteracting forces associated with the reaction between the stator and the rotor of the electromagnetic thrust bearing system.

Priority:

Inventor: RESS JR ROBERT ANTHONY [US]; HENRY MARK STEPHEN [US]


Patent No.: US6235228B1  Issued: 22/May/2001

Title: Method for on-mold coating molded articles with a coating powder as a liquid gel coat replacement

Applicant/Assignee: MORTON INTERNATIONAL, INC

Application No.: 09/288765   Filing Date: 08/Apr/1999

Abstract:

Method for on-mold surface coating fiberglass-reinforced molded articles during their manufacture with environmentally friendly and physiologically safe thermosetting unsaturated polyester on-mold coating powders which serve as replacements for liquid gel coats. The thermosetting coating powders employed are adapted to cure at low temperatures to avoid causing thermal damage to the heat sensitive plastic molds which must be reused over and over again, and to cure in the presence of atmospheric oxygen to enable over coating with liquid fill resins and fiberglass, which constitute the bulk of the finished article, without having the fill resins bleed through the powder coating film and detrimentally affect the overall quality of the surface finish.

Priority:

Inventor: NICHOLL EDWARD G [US]; SHAH NAVIN B [US]


Patent No.: US6235292B1  Issued: 22/May/2001

Title: Transfer-free make-up or care composition containing an organopolysiloxane and a fatty phase

Applicant/Assignee: L'OREAL

Application No.: 08/994435   Filing Date: 19/Dec/1997

Abstract:

A transfer-free composition containing an organopolysiloxane and a fatty phase containing at least one oil which is volatile at room temperature, particularly a make-up or care composition for the lips or a make-up foundation composition both for the human face and the body. This composition is gentle to apply, spreads easily, is non-sticky and does not dry the skin or the lips.

Priority: FR19960015984 Applic. Date: 1996-12-24

Inventor: BARA ISABELLE [FR]; AUGUSTE FREDERIC [FR]


Patent No.: US6235312B1  Issued: 22/May/2001

Title: Liquid crystalline phase drug delivery vehicle

Applicant/Assignee: EASTMAN CHEMICAL COMPANY

Application No.: 09/312109   Filing Date: 14/May/1999

Abstract:

The composition disclosed herein comprises about 55 to about 90 weight percent of a monoglyceride component comprising a monoglyceride having an acyl chain of 12 to 22 carbons, about 5 to about 35 weight percent of an acetylated monoglyceride component comprising an acetylated monoglyceride having an acyl chain of 12 to 22 carbons, and about 2 to about 40 weight percent water. The present composition is a liquid crystalline phase composition at a temperature of about 20 to about 80 DEG C., preferably a cubic liquid crystalline gel.

Priority:

Inventor: HOBBS HOWARD KENNETH [US]; BENKENDORF SOL [US]; WU STEPHEN HONG-WEI [US]


Patent No.: US6238650B1  Issued: 29/May/2001

Title: Sunscreen composition containing sol-gel microcapsules

Applicant/Assignee: SOL-GEL TECHNOLOGIES LTD

Application No.: 09/318828   Filing Date: 26/May/1999

Abstract:

The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

Priority:

Inventor: LAPIDOT NOA [IL]; MAGDASSI SHLOMO [IL]; AVNIR DAVID [IL]; ROTTMAN CLAUDIO [IL]; GANS ORIT [IL]; SERI-LEVY ALON [IL]


Patent No.: US6238654B1  Issued: 29/May/2001

Title: Cosmetic compositions comprising a film-forming polymer

Applicant/Assignee: L'OREAL

Application No.: 09/348258   Filing Date: 07/Jul/1999

Abstract:

A composition containing a physiologically acceptable medium of oil-in-water or water-in-oil type, thickened by an associative polyurethane. The composition has viscoelastic properties allowing it to recover its initial appearance after each use. The composition may be used as, for example, a makeup foundation.

Priority: FR19980008687 Applic. Date: 1998-07-07

Inventor: TOURNILHAC FLORENCE [FR]; LEMANN PATRICIA [FR]


Patent No.: US6238655B1  Issued: 29/May/2001

Title: alpha-amides of L-amino acids as fragrance precursors

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 08/990989   Filing Date: 15/Dec/1997

Abstract:

Disclosed are alpha-amides of L-amino acids that produce fragrance or attenuate or mask malodor. In particular, threonine amides, glycine amides, serine amides, and alanine amides can be used in the invention. Such alpha-amides of L-amino acids are useful for generating pleasant fragrances or attenuating or masking malodor upon cleavage of the alpha-amides of L-amino acids by bacteria in axillae. The alpha-amides of L-amino acids can be incorporated into skin treatment compositions and personal care products, such as deodorants, body sprays and antiperspirants, and used in methods for producing fragrance or attenuating or masking malodor.

Priority:

Inventor: SLIFE CHARLES W [US]; LANEY JUDITH WOLFE [US]; GOLDMAN VIRGINIA STREUSAND [US]


Patent No.: US6238656B1  Issued: 29/May/2001

Title: Cosmetic raw materials, cosmetic products, and methods of manufacturing cosmetic products

Applicant/Assignee: DOW CORNING TORAY SILICONE CORPORATION, LTD

Application No.: 09/335028   Filing Date: 17/Jun/1999

Abstract:

A cosmetic raw material provides uniform dispersions of silicone oils and crosslinked silicone particles in cosmetic products. The cosmetic products consist of the cosmetic raw material combined with other types of cosmetic raw materials. This provides pleasant sensations of touch with the fingers and skin, improved rubbing properties, and sensation in their use. The method of manufacturing the cosmetic products has a high efficiency. The cosmetic raw material is made from a silicone oil emulsion containing crosslinked silicone particles having an average diameter of 0.05-100 mum which are contained in silicone oil drops having an average diameter of 0.1-500 mum, the drops in turn being dispersed in water. The diameter of the crosslinked silicone particles is less than the diameter of the silicone oil drops.

Priority: JP19980192507 Applic. Date: 1998-06-23; JP19990016277 Applic. Date: 1999-01-25

Inventor: MORITA YOSHITSUGU [JP]; KOBAYASHI KAZUO [JP]; TACHIBANA RYUJI [JP]; HAMACHI TADASHI [JP]; OZAKI MASARU [JP]


Patent No.: US6238678B1  Issued: 29/May/2001

Title: Methods of regulating skin appearance with vitamin B3 compound

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/039750   Filing Date: 16/Mar/1998

Abstract:

The present invention relates to topical compositions comprising a vitamin B3 compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

Priority: US1997-834010 Applic. Date: 1997-04-11; US1995-554067 Applic. Date: 1995-11-06; US19960016043P Applic. Date: 1996-04-23; US19960025242P Applic. Date: 1996-09-16; US19960028902P Applic. Date: 1996-10-21

Inventor: OBLONG JOHN ERICH [US]; BISSETT DONALD LYNN [US]; BIEDERMANN KIMBERLY ANN [US]


Patent No.: US6238689B1  Issued: 29/May/2001

Title: Intestinal absorption of nicotine to treat nicotine responsive conditions

Applicant/Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Application No.: 09/147516   Filing Date: 30/Apr/1999

Abstract:

A delayed and sustained release composition of an additive and/or toxic agent such as nicotine is delivered systemically in therapeutic amounts while avoiding the peak plasma levels which gives rise to addiction and/or toxic side effects. The composition is delivered for absorption predominantly from the colon.

Priority: WO1997GB01938 Applic. Date: 1997-07-16; GB19960014902 Applic. Date: 1996-07-16

Inventor: RHODES JOHN [GB]; EVANS BRIAN K [GB]; RHODES PETER [GB]; SANDBORN WILLIAM J [US]


Patent No.: US6241976B1  Issued: 05/Jun/2001

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/547445   Filing Date: 12/Apr/2000

Abstract:

An antiperspirant composition is a structured emulsion of a continuous phase containing water-immiscible liquid carrier plus a structurant, and a disperse phase which is a solution of antiperspirant active in water or a mixture of water and water-soluble solvent. The structurant is a fully or partially esterified saccharide. The compositions give low visible residue when applied to skin or to clothing.

Priority: GB19990008223 Applic. Date: 1999-04-12

Inventor: ESSER ISABELLE CLAIRE [GB]; FRANKLIN KEVIN RONALD [GB]; GRAINGER LYNDA [GB]; KOWALSKI ADAM JAN [GB]; ROWE KATHRYN ELIZABETH [GB]


Patent No.: US6241993B1  Issued: 05/Jun/2001

Title: Therapeutic/cosmetic compositions comprising bradykinin antagonists for treating sensitive human skin

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/087803   Filing Date: 01/Jun/1998

Abstract:

Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the alpha-hydroxy and beta-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one bradykinin antagonist.

Priority: FR19950009304 Applic. Date: 1995-07-31; US1996-688738 Applic. Date: 1996-07-31

Inventor: BRETON LIONEL [FR]; DE LACHARRIERE OLIVIER [FR]


Patent No.: US6241998B1  Issued: 05/Jun/2001

Title: Dermatological patch

Applicant/Assignee: ACUTEK INTERNATIONAL

Application No.: 09/241389   Filing Date: 02/Feb/1999

Abstract:

A dermatological patch for removing keratotic plugs from pores of the skin to improve the health and appearance of skin. The patch comprises a pad having a lower surface having a polymeric adhesive composition, which does not require premoisturization of the patch by the user to effect its operation. The patch can be of different shapes, formed of transparent, clear or colored material so as to enhance its cosmetic appearance on the skin, and contain additives to enhance the use of the patch for improving skin health.

Priority:

Inventor: MUCHIN JEROME D [US]


Patent No.: US6242229B1  Issued: 05/Jun/2001

Title: Cosmetic/pharmaceutical compositions comprising microorganism culture media

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/072560   Filing Date: 05/May/1998

Abstract:

Cosmetic/pharmaceutical compositions, suitable for cosmetic applications and/or for treating a wide variety of mammalian disorders or disease states, comprise an effective active principle amount of a clarified and stabilized culture medium for at least one non-photosynthetic filamentous bacterium, advantageously belonging to the genera Beggiatoa, Vitreoscilla, Flexithrix or Leucothrix, formulated into a cosmetically/pharmaceutically acceptable vehicle, diluent or carrier therefor.

Priority: FR19970005510 Applic. Date: 1997-05-05

Inventor: PINEAU NATHALIE [FR]; MARTIN RICHARD [FR]; BRETON LIONEL [FR]; AUBERT LUCIEN [FR]


Patent No.: US6245322B1  Issued: 12/Jun/2001

Title: Fluid composition in the form of an oil-in-water emulsion comprising an acrylic terpolymer and its uses, in particular its cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/503200   Filing Date: 14/Feb/2000

Abstract:

A fluid composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase and comprising up to 0.5% by weight of active material with respect to the total weight of the composition of at least one acrylic terpolymer obtained from a carboxylic acid comprising alpha,beta-ethylenic unsaturation, from a non-surface-active monomer comprising ethylenic unsaturation other than (a), and from a non-ionic urethane monomer which is the reaction product of a monohydric non-ionic amphiphilic compound with an isocyanate comprising monoethylenic unsaturation. The composition may be used, for example, for caring for, removing make-up from, cleansing and/or scenting the skin, hair and/or lips. The composition may also be used for impregnating fabrics intended for cleansing and/or removing make-up from the skin, lips and/or eyes.

Priority: FR19990003319 Applic. Date: 1999-03-17

Inventor: SIMON PASCAL [FR]


Patent No.: US6245343B1  Issued: 12/Jun/2001

Title: Solid foaming pulverulent composition to be hydrated for caring for or cleaning the skin

Applicant/Assignee: L'OREAL

Application No.: 09/332901   Filing Date: 15/Jun/1999

Abstract:

The invention relates to a foaming pulverulent composition for cleaning and/or caring for the skin. The composition includes a cosmetically acceptable binder and a pulverulent filler which is insoluble in the binder and which is present in an amount sufficient to structure the composition and to confer on it the appearance of a deformable solid in which the binder is trapped. The pulverulent filler includes solid particles of thermoplastic polymer and at least one surfactant in pulverulent form. The composition foams when it is hydrated.

Priority: FR19980007519 Applic. Date: 1998-06-15

Inventor: ROULIER VERONIQUE [FR]; DAUBIGE THERESE [FR]; GUILLOU VERONIQUE [FR]


Patent No.: US6245811B1  Issued: 12/Jun/2001

Title: Fatty acid esters as bioactive compounds

Applicant/Assignee: SCOTIA HOLDINGS PLC

Application No.: 09/376617   Filing Date: 18/Aug/1999

Abstract:

Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R2 is as R1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C1-C4 alkyl group.

Priority: GB19950008823 Applic. Date: 1995-05-01; GB19950017107 Applic. Date: 1995-08-21; GB19960005440 Applic. Date: 1996-03-15

Inventor: HORROBIN DAVID FREDERICK [GB]; MANKU MEHAR [GB]; MCMORDIE AUSTIN [GB]; KNOWLES PHILIP [GB]; REDDEN PETER [GB]; PITT ANDREA [GB]


Patent No.: US6248311B1  Issued: 19/Jun/2001

Title: Photoprotective/cosmetic compositions comprising bisresorcinyltriazine and benzoazolyl/benzodiazolyl

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/503944   Filing Date: 14/Feb/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one bisresorcinyltriazine compound, and (b) at least one compound containing two benzoazolyl groups, or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990001732 Applic. Date: 1999-02-12

Inventor: CANDAU DIDIER [FR]


Patent No.: US6248312B1  Issued: 19/Jun/2001

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/548310   Filing Date: 12/Apr/2000

Abstract:

A cosmetic composition preferably an antiperspirant composition, in solid or soft-solid form has a continuous phase which contains a water-immiscible liquid carrier and also contains a structurant which is partially or fully esterified cellobiose of the formulawherein each Z is independently hydrogen or an acyl group of the formulawhere R denotes a hydrocarbyl group containing from 4 to 22 carbon atoms. Not more than half of the Z groups are hydrogen.

Priority: GB19990008202 Applic. Date: 1999-04-12

Inventor: FRANKLIN KEVIN RONALD [GB]; KOWALSKI ADAM JAN [GB]; PARROTT DAVID TERENCE [US]; ROWE KATHRYN ELIZABETH [GB]; WHITE MICHAEL STEPHEN [GB]


Patent No.: US6248341B1  Issued: 19/Jun/2001

Title: Method of treating topical angiogenesis-related disorders

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 09/483952   Filing Date: 14/Jan/2000

Abstract:

The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.

Priority:

Inventor: ANDERSON JON [US]; MATSUI MARY STEIDL [US]


Patent No.: US6248349B1  Issued: 19/Jun/2001

Title: Dissolution liquid for drug in iontophoresis

Applicant/Assignee: HISAMITSU PHARMACEUTICAL CO., INC

Application No.: 09/137744   Filing Date: 21/Aug/1998

Abstract:

A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is transdermally delivered by iontophoresis. The humectant includes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologically active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.

Priority: JP19950142983 Applic. Date: 1995-06-09; JP19950201902 Applic. Date: 1995-08-08; US1996-659372 Applic. Date: 1996-06-06

Inventor: SUZUKI YASUYUKI [JP]; IGA KATSUMI [JP]; MATSUMOTO YUKIHIRO [JP]


Patent No.: US6248352B1  Issued: 19/Jun/2001

Title: Compositions containing lipid compounds derived from sphingoid bases, their process of preparation

Applicant/Assignee: L'OREAL S.A

Application No.: 09/265392   Filing Date: 10/Mar/1999

Abstract:

The invention encompasses compounds corresponding to the formulain whichR1 denotes a C1-C31, preferably C9-C25, hydrocarbon-comprising radical, in particular a saturated or unsaturated, linear or branched, C1-C31, preferably C9-C25, alkyl radical which can be substituted by one or more optionally esterified hydroxyls

and OR2 denotes a cholesteryl radical

the said compounds being in the form of a pure enantiomer or in the form of a mixture of isomers. The invention also relates to their process of preparation and to their use, in particular for the treatment and care of the skin, hair, nails and eyelashes, in cosmetics or in dermatology.

Priority: FR19980002915 Applic. Date: 1998-03-10

Inventor: SEMERIA DIDIER [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6248749B1  Issued: 19/Jun/2001

Title: Use of inhibitors of the activity of retinoic acid for treating sensit ive skin and/or acute damage induced by UV radiation

Applicant/Assignee: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA

Application No.: 09/091981   Filing Date: 04/Sep/1998

Abstract:

The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation.

Priority: FR19960013362 Applic. Date: 1996-10-31; WO1997FR01879 Applic. Date: 1997-10-20

Inventor: DEMARCHEZ MICHEL [FR]; JOMARD ANDRE [FR]


Patent No.: US6251373B1  Issued: 26/Jun/2001

Title: Photoprotective/cosmetic compositions comprising benzotriazole, bisresorcinyltriazine and benzoazolyl/benzodiazolyl sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/503942   Filing Date: 14/Feb/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar ratiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one benzotriazole compound, (b) at least one bisresorcinyltriazine compound and (c) at least one compound containing at least two benzoazolyl groups per molecule and/or at least one compound containing, per molecule, at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990001731 Applic. Date: 1999-02-12

Inventor: CANDAU DIDIER [FR]


Patent No.: US6251376B1  Issued: 26/Jun/2001

Title: Antiperspirant product and method

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA

Application No.: 09/395950   Filing Date: 14/Sep/1999

Abstract:

An antiperspirant product for the human skin, comprising an antiperspirant active for topical application, and an effective amount of a compound which inhibits the acidification mechanism in the eccrine gland to elevate the pH of sweat.

Priority: GB19980019991 Applic. Date: 1998-09-14

Inventor: BECK JON [GB]; BURRY JASON S [GB]; COULSON HELEN F [GB]


Patent No.: US6251377B1  Issued: 26/Jun/2001

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/592130   Filing Date: 12/Jun/2000

Abstract:

A cosmetic composition, preferably an antiperspirant stick, has a carrier liquid which is almost exclusively silicone oil, structured with lanosterol. Instability is avoided by nearly complete exclusion or complete exclusion of silicon-free organic liquids.

Priority: GB19990013954 Applic. Date: 1999-06-15

Inventor: FRANKLIN KEVIN RONALD [GB]


Patent No.: US6251954B1  Issued: 26/Jun/2001

Title: Aerated composition, process for its manufacture and its use

Applicant/Assignee: L'OREAL

Application No.: 09/553412   Filing Date: 20/Apr/2000

Abstract:

An aerated composition comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase, characterized in that it contains air or inert gas in a sufficient amount to have a relative density ranging from 0.2 to 0.8 and in that it comprises at least one amphiphilic polymer and at least one anionic surfactant. The composition exhibits a very fine texture and good cosmetic properties, while remaining very stable over time. In particular, it can constitute a cosmetic composition intended especially for treating and/or cleansing the skin, including the scalp, nails and/or hair and for making up the skin.

Priority: FR19990004968 Applic. Date: 1999-04-20

Inventor: ROULIER VERONIQUE [FR]; DAUBIGE THERESE [FR]


Patent No.: US6254876B1  Issued: 03/Jul/2001

Title: Transfer-resistant cosmetic composition comprising a dispersion of polymer particles in a liquid fatty phase

Applicant/Assignee: L'OREAL

Application No.: 09/217808   Filing Date: 22/Dec/1998

Abstract:

A composition suitable for topical application, comprising a liquid fatty phase, at least one dye, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase. The present invention also provides a composition suitable for topical application, comprising a cosmetic, dermatological, hygiene or pharmaceutical liquid fatty phase, at least one active agent selected from the group consisting of cosmetic, dermatological, hygiene and pharmaceutical active agents, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase.

Priority: FR19970016251 Applic. Date: 1997-12-22

Inventor: DE LA POTERIE VALERIE [FR]; MOUGIN NATHALIE [FR]


Patent No.: US6254877B1  Issued: 03/Jul/2001

Title: Transfer-free cosmetic composition comprising a dispersion of non-film-forming polymer particles in a partially nonvolatile liquid fatty phase

Applicant/Assignee: L'OREAL

Application No.: 09/218073   Filing Date: 22/Dec/1998

Abstract:

The present invention relates to a care and/or make-up anhydrous composition, in particular a cosmetic, dermatological, hygienic or pharmaceutical composition, for the skin, which may be provided in the form of a cast product or a gel comprising at least one, in particular pulverulent, coloring matter and a dispersion of non-film-forming polymer particles which are surface-stabilized in a partially nonvolatile liquid fatty phase. Depending on the quantity of polymer and of nonvolatile oil, it is possible to obtain, on the lips or the skin, a nonfatty soft film having remarkable transfer-free properties, while imparting a very high degree of comfort. The invention also relates to the use of this dispersion in such a composition.

Priority: FR19970016252 Applic. Date: 1997-12-22

Inventor: DE LA POTERIE VALERIE [FR]; MOUGIN NATHALIE [FR]


Patent No.: US6255297B1  Issued: 03/Jul/2001

Title: Salicylic acid derivatives and their use in cosmetic or dermatological compositions

Applicant/Assignee: L'OREAL

Application No.: 09/367307   Filing Date: 26/Oct/1999

Abstract:

The invention relates to novel salicylic acid derivatives and to the use thereof in a cosmetic and/or dermatological composition intended for skincare, in particular to combat the signs of ageing of the skin and/or to improve the radiance of the complexion and/or to smooth out facial and/or body skin and/or to treat wrinkles and fine lines on the skin and/or to stimulate the process of epidermal renewal.

Priority: FR19970001617 Applic. Date: 1997-02-12; WO1998FR00231 Applic. Date: 1998-02-06

Inventor: DALKO MARIA [FR]; GALEY JEAN-BAPTISTE [FR]


Patent No.: US6255332B1  Issued: 03/Jul/2001

Title: Use of oxazolidinone derivatives as anti-penetrating agents in a cosmetic and/or dermatological composition

Applicant/Assignee: L'OREAL

Application No.: 08/949822   Filing Date: 14/Oct/1997

Abstract:

The use of oxazolidinone derivatives in a composition for topical application, especially a cosmetic or dermatological composition, in particular as anti-penetrating agents. These derivatives make it possible especially to prevent the penetration of active agents which are compatible with the skin, the hair and/or mucous membranes, and thus to reduce, or even eliminate altogether, the side effects of these active agents without decreasing their efficacy. Thus, the cosmetic or dermatological compositions containing such active agents make it possible to soften the skin, mucous membranes and the hair.

Priority: FR19960012509 Applic. Date: 1996-10-14

Inventor: PHILIPPE MICHEL [FR]; TULOUP REMY [FR]; MORANCAIS JEAN-LUC [FR]


Patent No.: US6258368B1  Issued: 10/Jul/2001

Title: Antimicrobial wipes

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/868717   Filing Date: 04/Jun/1997

Abstract:

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for cleansing skin, reducing the number of germs on the skin, and providing residual effectiveness versus Gram positive and Gram negative bacteria using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BAKKEN THERESA ANNE [US]; EVANS MARCUS WAYNE [US]


Patent No.: US6258370B1  Issued: 10/Jul/2001

Title: Compositions for disinfection of skin and mucous membrane

Applicant/Assignee: AIR LIQUIDE SANTE (INTERNATIONAL)

Application No.: 09/297503   Filing Date: 08/Jun/1999

Abstract:

A process and compositions for disinfecting the skin, hands and mucous membrane. The compositions contain an optical brightener and exhibit intense fluorescence in the visible wavelength range on exposure to UV light and thus permit simple monitoring of the treated skin or mucous membrane surfaces for ensuring complete disinfection, but without exhibiting the disadvantages associated with the use of conventional dyes, such as discoloration of the skin and articles.

Priority: DE19961046759 Applic. Date: 1996-11-04; WO1997EP06041 Applic. Date: 1997-10-28

Inventor: BEHRENDS SABINE [DE]; HARKE HANS-PETER [DE]


Patent No.: US6261543B1  Issued: 17/Jul/2001

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/416104   Filing Date: 12/Oct/1999

Abstract:

Antiperspirant emulsions which exhibit excellent phase stability even in the presence of an effective concentration of antiperspirant salts in solution and which are thickened are obtainable by dispersing a hydratable polymer and particularly an amphoteric or cationic modified starch in an aqueous emulsion forming a viscous emulsion, often at an elevated temperature, subjecting the emulsion to high shear, thereby reducing the droplet size of the dispersed oil phase, bringing the emulsion to below 40 DEG C. and introducing the antiperspirant, preferably in aqueous solution. The viscous emulsion subjected to high shear mixing desirably has a Sheer Stress of 10 to 500 Pa. The resultant emulsions show good phase stability even when they contain aluminium/ zirconium antiperspirant salts that promote instability and even at elevated storage temperatures such as at 50 DEG C.

Priority: GB19980022518 Applic. Date: 1998-10-15

Inventor: FLETCHER NEIL ROBERT [GB]; KANDA MIYUKI [JP]; KETELSON HOWARD ALLEN [CA]; TURNER GRAHAM ANDREW [GB]


Patent No.: US6261578B1  Issued: 17/Jul/2001

Title: Cosmetic composition containing a polysaccharide and an acrylic terpolymer, and use of this composition for the treatment of keratinous material

Applicant/Assignee: L'OREAL

Application No.: 09/332006   Filing Date: 14/Jun/1999

Abstract:

The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one polysaccharide and an acrylic terpolymer, as well as to the use of these compositions for treating the skin or the hair.The acrylic terpolymer comprises:a) about 20 to 70% by weight of a carboxylic acid containing alpha, beta-monoethylenic unsaturation

b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), andc) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation.The polysaccharide is preferably a guar gum.

Priority: FR19980007515 Applic. Date: 1998-06-15

Inventor: DUPUIS CHRISTINE [FR]


Patent No.: US6261593B1  Issued: 17/Jul/2001

Title: Carrier patch for the delivery of agents to the skin

Applicant/Assignee: ACUTEK INTERNATIONAL

Application No.: 09/625001   Filing Date: 24/Jul/2000

Abstract:

A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

Priority: US1999-292625 Applic. Date: 1999-04-15

Inventor: MUCHIN JEROME D [US]; MUCHIN MICHAEL P [US]


Patent No.: US6262176B1  Issued: 17/Jul/2001

Title: Crosslinked water-soluble or water-dispersible polyurethanes

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 09/303426   Filing Date: 03/May/1999

Abstract:

The present invention relates to crosslinked, water-soluble or water-dispersible polyurethanes ofA) at least one water-soluble or water-dispersible polyurethane prepolymer having terminal isocyanate groups ofa) at least one compound having a molecular weight in the range from 56 to 300 which contains two active hydrogen atoms per molecule,b) at least one polymer containing two active hydrogen atoms per molecule,c) at least one compound which contains two active hydrogen atoms and at least one ionogenic or ionic group per molecule,d) at least one diisocyanate,B) at least one polymer containing groups which are reactive toward isocyanate groups, chosen from hydroxyl, and primary and secondary amino and/or carboxyl groups,or the salts thereof.

Priority: DE19981021732 Applic. Date: 1998-05-14

Inventor: KIM SON NGUYEN [DE]; SANNER AXEL [DE]; HOESSEL PETER [DE]; SCHEHLMANN VOLKER [DE]


Patent No.: US6264928B1  Issued: 24/Jul/2001

Title: Use of shogaols and gingerols for preparing deodorant compositions

Applicant/Assignee: SOCIETE D'ETUDES ET DE RECHERCHES EN PHARMACOGNOSIE

Application No.: 09/341383   Filing Date: 07/Sep/1999

Abstract:

A method is provided for suppressing body odors in a human by administering orally to the human or applying to the skin of the human, at least one compound chosen from the group consisting of shogaols and gingerols. The compound corresponds to the general formula:in which X represents:either -CH=CH-, in which case n is equal to 1, 2, 4, 6, or 8

-CH2-CH(OH)-, in which case n is equal to 2, 4, 6 or 8.

Priority: FR19970000142 Applic. Date: 1997-01-09; FR19970000143 Applic. Date: 1997-01-09; WO1998FR00025 Applic. Date: 1998-01-08

Inventor: JEAN DANIEL [FR]; CARIEL LEON [FR]


Patent No.: US6264930B1  Issued: 24/Jul/2001

Title: Hair and skin treatment product

Applicant/Assignee:

Application No.: 09/351826   Filing Date: 12/Jul/1999

Abstract:

A hair treating and skin care preparation for use alone or as a component in other preparations, for use in hair dyeing, bleaching, hair conditioning or skin treatments comprises a mixture of hydrogen peroxide, a silicon component selected from the group consisting of silica gel, silicic acid anhydride and mixtures thereof, and a relatively small amount of Aloe vera gel. Prior to use, at least 1.5 g of leaf material from an Aloe vera plant per liter of the hydrogen peroxide, silicon component and aloe vera mixture are placed in the mixture for at least 12 hours in order to dissolve active components from the leaf material and then the undissolved remnants are removed. The preparation can be used for treating skin conditions such as a rash or eczema. A similar preparation can also be combined with water and one or more herbs to provide a health providing remedy that is applied to the skin.

Priority: US1997-965565 Applic. Date: 1997-11-06

Inventor: LIZZI JOSEPH [CA]


Patent No.: US6264978B1  Issued: 24/Jul/2001

Title: Transdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG

Application No.: 08/256065   Filing Date: 04/Aug/1994

Abstract:

The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.

Priority: DE19914142483 Applic. Date: 1991-12-20; WO1992EP02914 Applic. Date: 1992-12-16

Inventor: BECHER FRANK [DE]; KISSEL THOMAS [DE]


Patent No.: US6264979B1  Issued: 24/Jul/2001

Title: Transdermal device for administration through de-epithelialized skin

Applicant/Assignee:

Application No.: 08/737713   Filing Date: 08/Nov/1996

Abstract:

A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.

Priority: WO1995EP01726 Applic. Date: 1995-05-08; GB19940009281 Applic. Date: 1994-05-10

Inventor: SVEDMAN PAL [SE]


Patent No.: US6265363B1  Issued: 24/Jul/2001

Title: Skin cleansing composition for removing ink

Applicant/Assignee: GOJO INDUSTRIES, INC

Application No.: 09/428250   Filing Date: 27/Oct/1999

Abstract:

A skin cleansing composition suitable for removing ink and other stains from the hands and arms of a user includes an effective amount of a low molecular weight alcohol having from one to twelve carbon atoms and an effective amount of a peroxide releasing agent, e.g., a percarbonate salt, preferably sodium percarbonate, such that together, the alcohol and percarbonate salt provide a synergistic reaction that effectively removes ink from the skin of the user. Other additives such as fillers, abrasives, and detergents may be employed to provide further cleansing action.

Priority:

Inventor: VISCOVITZ JOHN [US]


Patent No.: US6265436B1  Issued: 24/Jul/2001

Title: Substituted 5-biphenyl-3,4-dihydroxy-2(5H)-furanones and method of use therefor

Applicant/Assignee: OXIS THERAPEUTICS INC

Application No.: 09/406544   Filing Date: 27/Sep/1999

Abstract:

The present invention broadly relates to racemic or optically active 5-substituted 3,4-dihydroxy-2(5H)-furanone compounds and their pharmaceutically acceptable salts, useful for treating a pathology in which reactive oxygen species and inflammatory mediators are contributing deleterious factors, such as acute or chronic inflammatory disorders, for example, asthma, rheumatoid arthritis, inflammatory bowel disease, and acute respiratory distress syndrome

neurodegenerative disorders, such as Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, traumatic brain injury and multiple sclerosis

cardiovascular diseases, such as atherosclerosis

viral diseases, such as AIDS

skin diseases, such as psoriasis, sunburn and premature aging

and eye diseases, such as glaucoma, cataract, senile macular degeneration, inflammatory eye conditions, trauma, post-traumatic eye disorders, diabetic retinopathy, and eye infections.

Priority: US1997-915099 Applic. Date: 1997-08-20; US19960024440P Applic. Date: 1996-08-22; US19960024586P Applic. Date: 1996-08-22

Inventor: APPERE GEORGES [FR]; ERDELMEIER IRENE [FR]; BANISSI CLAIRE [FR]; MOUTET MARC [FR]; HOPPER ALLEN [US]


Patent No.: US6265562B1  Issued: 24/Jul/2001

Title: Nucleic acid constructs whose activity is affected by inhibitors of cyclin-dependent kinases and uses thereof

Applicant/Assignee: AVENTIS PHARMA DEUTSCHLAND GMBH

Application No.: 09/215221   Filing Date: 18/Dec/1998

Abstract:

The present application discloses nucleic acid constructs comprising nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, fragments and variants thereof, some of which possess a dominant interfering character.

Priority: DE19971056975 Applic. Date: 1997-12-20

Inventor: EILERS MARTIN [DE]; BUERGIN ANDREA [DE]; SEDLACEK HANS-HARALD [DE]


Patent No.: US6267955B1  Issued: 31/Jul/2001

Title: Mononuclear phagocytes and their use to promote axonal regeneration

Applicant/Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 09/041280   Filing Date: 11/Mar/1998

Abstract:

Methods and compositions are disclosed for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as skin, dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. CNS administration of mononuclear phagocytes may optionally be combined with administration of an adjuvant factor (e.g. aFGF) to the CNS, anti-inflammatory therapy of the mammal, or both. Methods for screening stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

Priority: US1997-818818 Applic. Date: 1997-03-14; US1996-695351 Applic. Date: 1996-08-09; US1995-528845 Applic. Date: 1995-09-15

Inventor: EISENBACH-SCHWARTZ MICHAL [IL]; SPIEGLER ORLY [IL]; HIRSCHBERG DAVID L [US]


Patent No.: US6267972B1  Issued: 31/Jul/2001

Title: Cosmetic/pharmaceutical compositions comprising beta-adrenergic agonists/substance P antagonists

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/310099   Filing Date: 12/May/1999

Abstract:

Cosmetic/pharmaceutical compositions, well suited for the treatment of a variety of mammalian disorders of, for example, the skin, hair and/or mucous membranes, a manifestation of which is an excess in the synthesis and/or in the release of substance P, e.g., for the treatment of cutaneous disorders and sensitive skin, comprise an effective substance P antagonist amount of at least one beta-adrenergic agonist, e.g., salbutamol, in a cosmetically/pharmaceutically acceptable medium therefor.

Priority: FR19950012447 Applic. Date: 1995-10-23; US1996-731967 Applic. Date: 1996-10-23

Inventor: BRETON LIONEL [FR]; DE LACHARRIERE OLIVIER [FR]; LECLAIRE JACQUES [FR]


Patent No.: US6267975B1  Issued: 31/Jul/2001

Title: Personal care articles

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/443651   Filing Date: 19/Nov/1999

Abstract:

The present invention relates to a substantially dry, disposable personal cleansing article comprising:a) a water insoluble substrate comprising:1) a first layer which exhibits a Loft-Soft Ratio of greater than about 1.1

2) a second layer, disposed adjacent to said first layer, wherein said second layer exhibits a Loft-Soft Ratio of less than about 1.2

b) a cleansing component disposed adjacent to said first and second layers, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant.The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit component in addition to or in lieu of the cleansing component.These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair.

Priority: US19990146693P Applic. Date: 1999-08-02

Inventor: SMITH III EDWARD DEWEY [US]; LORENZI MARC PAUL [GB]


Patent No.: US6267978B1  Issued: 31/Jul/2001

Title: Water-in-oil emulsions containing amino acid salts of salicylic acid

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/696611   Filing Date: 25/Oct/2000

Abstract:

A cosmetic composition in the form of a water-in-oil emulsion comprising: (a) continuous oil phase

and (b) discontinuous aqueous phase

and (c) amino acid salt of salicylic acid or salicylic acid derivative. The compositions of the invention provide regulation of the oily and/or shiny appearance of the skin.

Priority: GB19960013458 Applic. Date: 1996-06-27; GB19960019109 Applic. Date: 1996-09-12

Inventor: SANG CHUNE [GB]; STONEHOUSE JONATHAN RICHARD [GB]


Patent No.: US6270811B1  Issued: 07/Aug/2001

Title: Pharmaceutical, cosmetic composition with base of microbial culture mixed with an essential oil and an acid

Applicant/Assignee: 1 FOIS 1 JOUR CONCEPT

Application No.: 09/308250   Filing Date: 25/May/1999

Abstract:

The invention concerns a cosmetic or pharmaceutical composition. This composition is characterised in that it contains a microbial culture compatible in cosmetics or in pharmacy or in therapy, in particular a culture of micro-organisms selected among the acetic or lactic bacteria, freeze-dried yeast, suspensions of micro-organisms, fermented organic substances, for example fermented pollen, or an inactivated culture of bacteria of the genus bifidobacterium or of bacteria related to this genus mixed with an essential oil and an acid preferably an organic acid, such as citric acid. This composition has an activity for regenerating the skin, in particular anti-wrinkle properties, for erasing old scars, for repairing burnt tissues, for promoting skin healing, for eliminating pigmentary spots and also for promoting growth or fresh growth of superficial body growth including nails, hair or hairs.

Priority: FR19960014442 Applic. Date: 1996-11-26; WO1997FR02127 Applic. Date: 1997-11-26

Inventor: FREGONESE ALEXANDRA [FR]


Patent No.: US6271219B2  Issued: 07/Aug/2001

Title: TOPICAL FORMULATIONS COMPRISING SKIN PENETRATION AGENTS AND THE USE THEREOF

Applicant/Assignee:

Application No.: 09/406918   Filing Date: 28/Sep/1999

Abstract:

Disclosed are topical pharmaceutical compositions comprising a pharmaceutically active agent such as a corticosteroid, a diol, cetyl alcohol, glyceryl monostearate, laurocapram, stearyl alcohol, sodium lauryl sulfate and water. Also disclosed is a method for the manufacture of the compositions and methods for treating inflammatory skin conditions with the compositions.

Priority: US19990140756P Applic. Date: 1999-06-25

Inventor: VAIDYANATHAN RAJARAM [US]; VO PHUONG M [US]; MANNING GEORGE N [US]; GERHART DONALD J [US]; HELMY ATEF A [US]; ALLAN GEOFFREY [US]


Patent No.: US6271327B1  Issued: 07/Aug/2001

Title: Water-soluble polymers and their use in cosmetic formulations

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 09/230352   Filing Date: 25/Jan/1999

Abstract:

Water-soluble polymers whose characteristic structural elements comprise units of the formulae I and/or IIwhereR1 is H, alkyl, cycloalkyl, aryl or aralkyl,R2 and R3 independently are as defined for R1 or are selected from substituted alkyl, substituted cycloalkyl, substituted aryl or substituted aralkyl, the substituents being selected from OH, O-alkyl, O-aryl, SH, S-alkyl, S-aryl, NH2, NH-alkyl, NH-aryl, N(alkyl)2, possibly in protinated form,N(Alkyl)3+3Z-, where Z is the radical of an inorganic ororganic acid, COOH, COO-alkyl, CONH2, CONH-alkyl, CON(alkyl)2, CN and SO3H

andthe indices x are each independently an integer from 1 to 20

and the acid addition salts of these polymers, (processes for whose preparation are also described), are used in cosmetic compositions.

Priority: DE19961030977 Applic. Date: 1996-07-31; WO1997EP04122 Applic. Date: 1997-07-29

Inventor: NIESSNER MANFRED [DE]; RUEBENACKER MARTIN [DE]; NILZ CLAUDIA [DE]; HOESSEL PETER [DE]


Patent No.: US6274124B1  Issued: 14/Aug/2001

Title: Additive for improving the water resistance of cosmetic or dermatological formulations

Applicant/Assignee: DRAGOCO GERBERDING & CO. AG

Application No.: 09/378402   Filing Date: 20/Aug/1999

Abstract:

A method for imparting water resistance to or improving water resistance of a cosmetic or dermatological formulation, comprising adding an water resistance enhancing effective amount of 1,2-pentanediol to the otherwise conventional cosmetic or dermatological formulation comprising at least one cosmetic and/or dermatological active agent in a cosmetically and/or pharmaceutically acceptable carrier for topical application to the skin of humans.

Priority:

Inventor: VOLLHARDT JUERGEN [US]


Patent No.: US6274127B1  Issued: 14/Aug/2001

Title: Anhydrous antiperspirant compositions containing water-reactive monomers as antiperspirant active

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/491744   Filing Date: 27/Jan/2000

Abstract:

Disclosed are non-adhesive antiperspirant compositions comprising a water or sweat-reactive monomer as the antiperspirant active, an anhydrous carrier, and an optional polymerization inhibitor, wherein the compositions are applied topically to the underarm or other suitable area of the skin to inhibit or prevent perspiration. The applied compositions form a discontinuous polymer-containing antiperspirant active on the applied skin surface, wherein the polymer-containing active is derived from water-reactive monomers that reacts with sweat at the opening of the sweat ducts after application, to thereby polymerize and form the polymer-containing antiperspirant active over and within the affected sweat ducts. The antiperspirant compositions and corresponding methods of application provide alternative antiperspirant active materials and product formulations, and provide improved efficacy and/or application cosmetics.

Priority:

Inventor: SCHRAER ROBERT MICHAEL [US]; RALEIGH PATRICIA SUE [US]; GARDLIK JOHN MICHAEL [US]


Patent No.: US6274150B1  Issued: 14/Aug/2001

Title: Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/468325   Filing Date: 21/Dec/1999

Abstract:

The present invention provides a nanoemulsion, that includes:an oily phase dispersed in an aqueous phase

andat least one anionic surfactant selected from the group including phosphoric acid fatty esters and oxyethylenated derivatives thereof, and mixtures thereof

whereinthe oily phase includes oil globules having a number-average size of less than 100 nm

wherein the oily phase includes at least one oil having a molecular weight of greater than 400

and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The nanoemulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, dermatological, cosmetic, opthalmic, and opthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

Priority: FR19980016370 Applic. Date: 1998-12-23

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6274166B1  Issued: 14/Aug/2001

Title: Transdermal delivery system

Applicant/Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

Application No.: 09/424525   Filing Date: 23/Nov/1999

Abstract:

A transdermal delivery system comprising an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent. The transdermal delivery system is an easy-to-use topical system that facilitates the penetration of an active ingredient, such as insulin, through the skin layers and into the blood stream. Additionally, the invention includes a method for treating diabetes and other pathologic systemic conditions comprising administering an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent.

Priority: IL19970120943 Applic. Date: 1997-05-29; WO1998IL00205 Applic. Date: 1998-05-04

Inventor: SINTOV AMNON [IL]; WORMSER URI [IL]


Patent No.: US6277364B1  Issued: 21/Aug/2001

Title: Polyurethanes as topical skin protectants

Applicant/Assignee: BERTEK PHARMACEUTICALS, INC

Application No.: 09/169208   Filing Date: 09/Oct/1998

Abstract:

Polyurethane compositions for the protection of skin from material that is harmful to the skin or substances that are capable of penetrating the skin, are described.

Priority:

Inventor: BUCKS DANIEL A W [US]; DORSKY ALBERT M [US]; HOU SUI YUEN EDDIE [US]


Patent No.: US6277385B1  Issued: 21/Aug/2001

Title: Cooling compositions with reduced stinging

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/375193   Filing Date: 18/Jan/1995

Abstract:

The present invention provides coolant compositions for topical application to the skin which can provide long-lasting cooling with low or reduced skin sting. The compositions comprise a mixture of specific type of acyclic carboxamide coolant with a specific type of 3-substituted-p-menthane coolant, an aqueous vehicle, and no more than about 30% C1-C6 monohydric alcohol.

Priority: US1994-185104 Applic. Date: 1994-01-21; US1992-900219 Applic. Date: 1992-06-17

Inventor: LUKE WILLIAM MICHAEL [US]


Patent No.: US6277388B1  Issued: 21/Aug/2001

Title: Stable gelled aqueous composition with a high electrolyte content

Applicant/Assignee: L'OREAL

Application No.: 09/405232   Filing Date: 24/Sep/1999

Abstract:

Compositions suitable for cosmetic and/or dermatological use which contain at least one electrolyte and/or at least one primary alcohol, at least one associative polyurethane, at least one oxyalkylenated polymer, and water.

Priority: FR19980012041 Applic. Date: 1998-09-25

Inventor: CHEVALIER VERONIQUE [FR]


Patent No.: US6277401B1  Issued: 21/Aug/2001

Title: Drug delivery device

Applicant/Assignee: U.S. DERMATOLOGICS, INC

Application No.: 09/307051   Filing Date: 07/May/1999

Abstract:

A drug delivery device includes (a) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic backing layer, (b) a moisture vapor permeable, flexible, oleophilic thermoplastic resin foam layer, (c) a pressure sensitive adhesive layer, and (d) a drug reservoir containing at least one hydrophilic drug composition and possessing a moisture vapor permeable, but hydrophilic drug composition impermeable, barrier layer applied to one surface thereof with the drug reservoir being applied to a portion of the adhesive layer such that the barrier layer lies between the hydrophilic drug composition and the adhesive layer thereby preventing any significant migration of the drug composition from the drug reservoir into the adhesive layer.

Priority:

Inventor: BELLO GASTONE P [US]; PACKMAN ELI W [US]


Patent No.: US6277418B1  Issued: 21/Aug/2001

Title: Corn extract contraceptive

Applicant/Assignee: BAYLOR COLLEGE OF MEDICINE

Application No.: 09/311751   Filing Date: 14/May/1999

Abstract:

Novel compositions extracted from corn products provide contraceptive and anti-neoplastic activities. Using novel extraction procedures, compositions may be isolated from corn products. For example, a Zea mays plant product is extracted in a first solvent to produce a solvent extract, the solvent extract is dried to produce an extracted solid, the extracted solid is solubilized in a second solvent, the solubilized extract is purified in a chromatographic process, and an active fraction is collected from the chromatographic process. Compositions may be applied to animal bedding or food, and are adaptable to any suitable method of administration. The contraceptive activity of these compositions is effective for both males and females.

Priority: US19980087680P Applic. Date: 1998-06-02

Inventor: MARKAVERICH BARRY M [US]; FAITH ROBERT [US]; MANI SHAILA [US]


Patent No.: US6277862B1  Issued: 21/Aug/2001

Title: Quinoline derivatives

Applicant/Assignee: SMITHKLINE BEECHAM S.P.A

Application No.: 09/077151   Filing Date: 22/May/1998

Abstract:

A compound, or a solvate or a salt thereof, of formula (I), wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring aromatic heterocyclic group

R, R1, R2 and R3 are as defined in the description

a process for the preparation of such a compound, a pharmaceutical composition containing such a compound or composition in medicine.

Priority: WO1996EP05203 Applic. Date: 1996-11-22; IT1995MI02461 Applic. Date: 1995-11-24; IT1996MI01689 Applic. Date: 1996-08-02

Inventor: GIARDINA GIUSEPPE ARNALDO MARI [IT]; GRUGNI MARIO [IT]; RAVEGLIA LUCA FRANCESCO [IT]; FARINA CARLO [IT]


Patent No.: US6277892B1  Issued: 21/Aug/2001

Title: Enhanced skin penetration system for improved topical delivery of drugs

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 08/191734   Filing Date: 04/Feb/1994

Abstract:

The invention relates to pharmaceutical compositions for topical application comprising a safe and effective amount of a pharmaceutical active, and from about 0.1% to about 10.0% of a high molecular weight cationic polymer. These compositions provide enhanced penetration of the pharmaceutical active.

Priority: US1993-059001 Applic. Date: 1993-05-06; US1992-948391 Applic. Date: 1992-09-25; US1991-778422 Applic. Date: 1991-10-16

Inventor: DECKNER GEORGE ENDEL [US]; LOMBARDO BRIAN SCOTT [US]


Patent No.: US6280746B1  Issued: 28/Aug/2001

Title: Dry emollient compositions

Applicant/Assignee: INTERNATIONAL FLORA TECHNOLOGIES LTD

Application No.: 09/010736   Filing Date: 22/Jan/1998

Abstract:

The present invention are dry-feel emollient compositions comprising jojoba oil based esters that have use in personal care, cosmetic, cosmaceutical and pharmaceutical products. These compositions are essentially solid at room temperature, can be provided in various shapes and sizes (especially as particulates such as spheres), and can be produced from combinations of fatty alcohols, isopropyl esters and wax esters obtained from the oil contained in the seed of the jojoba plant. These new compositions also increase the range of applications for cosmetic compositions through an emollient that is more polar and hydrophilic than is found in jojoba oils. The compositions of the present invention may be obtained by a novel process of a base catalyzed alcoholysis reaction between jojoba oil and an alcohol, such as isopropyl alcohol. These components, whether exclusively jojoba esters or when combined with other carrier and vehicle components (including other emollients or binders) can form excellent carrier composition for use in the cosmetic, personal care and/or pharmaceutical field. Typical materials with which the compositions of the present invention may be blended include, but are not limited to, cosmetic oils and waxes, both natural and synthetic, (including hydrogenated or partially hydrogenated oils), silicone oils, mineral oils, long chain esters, vitamins, long chain fatty acids, cosmeceuticals, pigments, botanical extracts, esters and ethers, dimers, trimers, oligomers, and polymers, and the like. The proportions of the jojoba esters should be chosen to provide the dry-feel to the composition, which is highly desired. This will usually require a weight percent that ranges from 10% to 100% by weight of carrier material in the composition.

Priority: US1997-953132 Applic. Date: 1997-10-17

Inventor: ARQUETTE DEMETRIOS JAMES G [US]; BROWN JIM [US]; REINHARDT JOHN [US]


Patent No.: US6280747B1  Issued: 28/Aug/2001

Title: Cosmetic or dermatological composition contacting at least one natural or recombinant spider silk or an analog

Applicant/Assignee: L'OREAL

Application No.: 09/247806   Filing Date: 11/Feb/1999

Abstract:

A cosmetic or dermatological composition containing, as an active substance, at least one natural or recombinant spider silk protein, or an analog of such a protein. The composition may be in the form of hair products, skincare products, make-up products or antisun products.

Priority: FR19980001614 Applic. Date: 1998-02-11

Inventor: PHILIPPE MICHEL [FR]; GARSON JEAN-CLAUDE [FR]; ARRAUDEAU JEAN-PIERRE [FR]


Patent No.: US6280750B1  Issued: 28/Aug/2001

Title: SOLID COSMETIC COMPOSITION AND USES THEREOF

Applicant/Assignee: L'OREAL

Application No.: 09/357956   Filing Date: 21/Jul/1999

Abstract:

A solid composition for topical application comprising, in an aqueous phase, a gelling system comprising (i) gellan gum, (ii) at least one other hydrocolloid chosen from the group formed by xanthan gum, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, agar-agar, carrageenans, alginates, carob gum, guar gum, gum arabic, karaya gum, gum tragacanth, ghatti gum, pectins, gelatin, caseinates and hydroxypropylguar, and (iii) at least one amphiphilic polymer comprising at least one fatty chain and at least one hydrophilic unit.

Priority: FR19980009793 Applic. Date: 1998-07-30

Inventor: ROULIER VERONIQUE [FR]; QUEMIN ERIC [FR]


Patent No.: US6280753B1  Issued: 28/Aug/2001

Title: Water containing wax-based product

Applicant/Assignee: E-L MANAGEMENT CORPORATION

Application No.: 09/424463   Filing Date: 25/Feb/2000

Abstract:

The present invention relates to a wax-based composition comprising at least about 0.5-30% water in a water-in-oil emulsion, wherein water is encapsulated in a lamellar lipid vesicle capable of withstanding wax melting point temperatures. The composition is useful in delivering water soluble actives in an anhydrous base, and is particularly well-adapted for uses in lipsticks and lip-care products.

Priority: US1997-864162 Applic. Date: 1997-05-28; WO1998US10725 Applic. Date: 1998-05-27

Inventor: CHUNG KENNY [US]; KEELER TRACY N [US]; TAN MANUEL L [US]


Patent No.: US6281009B1  Issued: 28/Aug/2001

Title: Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell

Applicant/Assignee: THE GENERAL HOSPITAL CORPORATION

Application No.: 08/927318   Filing Date: 11/Sep/1997

Abstract:

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.

Priority: US19960026294P Applic. Date: 1996-09-11

Inventor: BOYCE FREDERICK M [US]


Patent No.: US6284233B1  Issued: 04/Sep/2001

Title: Antiwrinkle composition comprising a combination of tightening polymers of synthetic and/or natural origin and of dendritic polyesters

Applicant/Assignee: L'OREAL

Application No.: 09/397521   Filing Date: 17/Sep/1999

Abstract:

The present invention relates to an antiwrinkle composition that includes, in a physiologically acceptable medium:a dispersion of a film-forming polymeric system containing at least one polymer capable of forming a film permeable to water vapor, having a Young's modulus ranging from 108 to 1010 N/m2 and producing, after application at a concentration of 7% in water and then drying, a retraction of the isolated stratum corneum greater than 1% at a temperature of 30 DEG C. and a relative humidity of 40%, anda dendritic polyester polymer having terminal hydroxyl functional groups.

Priority: FR19980011635 Applic. Date: 1998-09-17

Inventor: SIMON PASCAL [FR]; CHEVALIER VERONIQUE [FR]


Patent No.: US6284234B1  Issued: 04/Sep/2001

Title: Topical delivery systems for active agents

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 09/360412   Filing Date: 23/Jul/1999

Abstract:

This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.

Priority: US19980095289P Applic. Date: 1998-08-04

Inventor: NIEMIEC SUSAN M [US]; WANG JONAS C T [US]; WISNIEWSKI STEPHEN J [US]; STENN KURT S [US]; LU GWANG WEI [US]


Patent No.: US6284259B1  Issued: 04/Sep/2001

Title: Antimicrobial wipes which provide improved residual benefit versus Gram positive bacteria

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/969057   Filing Date: 12/Nov/1997

Abstract:

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5

and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BAKKEN THERESA ANNE [US]; CEN WEI [US]; CLAPP MANNIE LEE [US]; WARREN RAPHAEL [US]


Patent No.: US6284281B1  Issued: 04/Sep/2001

Title: Cosmetic composition comprising particles of melamine-formaldehyde or urea-formaldehyde resin and its uses

Applicant/Assignee: L'OREAL

Application No.: 09/542458   Filing Date: 04/Apr/2000

Abstract:

Cosmetic composition comprising particles of melamine-formaldehyde or urea-formaldehyde resin and its uses. The present application relates to a composition comprising, in a physiologically acceptable medium, at least one oily phase and particles of melamine-formaldehyde or urea-formaldehyde resin, to the use of the said composition, especially as a cosmetic composition for caring for and/or making up the skin, in particular for softening defects of the relief of the skin, such as microrelief features, wrinkles or pores, while conferring a natural appearance on the skin, and to its use in treating greasy skin. The particles advantageously have a number-average size ranging from approximately 0.1 to 20 mum. The composition of the invention can be anhydrous or can be provided in the form of a water-in-oil or oil-in-water emulsion. The invention also relates to the use of particles of melamine-formaldehyde or urea-formaldehyde resin as mattifying agent in a cosmetic composition.

Priority: FR19990005043 Applic. Date: 1999-04-21

Inventor: CHEVALIER VERONIQUE [FR]; HUREL VALERIE [FR]; SIMON PASCAL [FR]


Patent No.: US6284725B1  Issued: 04/Sep/2001

Title: Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue

Applicant/Assignee: BIONEBRASKA, INC

Application No.: 09/302596   Filing Date: 30/Apr/1999

Abstract:

Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like peptide-1. The invention relates to both the method and compositions for such treatment.

Priority: US19980103498P Applic. Date: 1998-10-08

Inventor: COOLIDGE THOMAS R [US]; EHLERS MARIO R W [US]


Patent No.: US6284802B1  Issued: 04/Sep/2001

Title: Methods for regulating the condition of mammalian keratinous tissue

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/541965   Filing Date: 04/Apr/2000

Abstract:

The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising:a) a safe and effective amount of farnesol

andb) a dermatologically-acceptable carrier for the farnesol.In additional embodiments, the above composition is suitable for thickening skin and preventing and/or retarding atrophy of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal, preventing and/or retarding sallowness of mammalian skin, preventing and/or retarding sagging of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing and/or relieving itch of mammalian skin.

Priority: US19990129975P Applic. Date: 1999-04-19

Inventor: BISSETT DONALD LYNN [US]; JEWELL-MOTZ ELIZABETH ANN [US]


Patent No.: US6287362B1  Issued: 11/Sep/2001

Title: Production of metal lumps and apparatus therefor

Applicant/Assignee: MINTEK

Application No.: 09/011765   Filing Date: 22/Jun/1998

Abstract:

Metal lumps or pebbles are produced by introducing a molten metal stream into a stream of water in a direction which is substantially the same as the direction of the water stream and at a velocity which is substantially the same or slightly less than the velocity of the water stream.

Priority: WO1996GB02209 Applic. Date: 1996-09-09; ZA19950007505 Applic. Date: 1995-09-07

Inventor: LEVEY FIONA CATHERINE [ZA]; CORTIE MICHAEL BERNARD [ZA]; BARKER IAN JAMES [ZA]


Patent No.: US6287544B1  Issued: 11/Sep/2001

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/547604   Filing Date: 12/Apr/2000

Abstract:

A cosmetic composition preferably an antiperspirant composition, in solid or soft-solid form has a continuous phase which contains a water-immiscible liquid carrier and also contains a structurant which is partially or fully esterified cellobiose of the formulawherein each Z is independently hydrogen or an acyl group of the formulawhere R denotes a hydrocarbyl group containing from 4 to 22 carbon atoms. Not more than half of the Z groups are hydrogen.

Priority: GB19990008218 Applic. Date: 1999-04-12

Inventor: FRANKLIN KEVIN RONALD [GB]; KOWALSKI ADAM JAN [GB]; ESSER ISABELLE CLAIRE [GB]; ROWE KATHRYN ELIZABETH [GB]


Patent No.: US6287548B1  Issued: 11/Sep/2001

Title: Treatment of acne, seborrheic dermatitis and other skin diseases with salt solution containing NACL

Applicant/Assignee: BIO.LIFE INTERNATIONAL AG

Application No.: 08/342614   Filing Date: 21/Nov/1994

Abstract:

The present invention provides a composition of matter which has been demonstrated to be a very effective treatment for acne, seborrheic dermatitis and related skin diseases when applied to and contacted with affected skin areas, while avoiding the disadvantages and complications attendant to more established treatments. The composition comprises a synthetic mixture of salts which, when dissolved in a solvent such as water, is ionically composed primarily of a mixture of sodium and magnesium cations and chloride and sulfate anions, and which is preferably free of added zinc. More specifically, the salt mixture according to the present invention comprises the following range of composition in grams/kilogram of salt mixture in the ionic state, the balance being water of hydration:

Priority: DE19934339750 Applic. Date: 1993-11-22; DE19934339751 Applic. Date: 1993-11-22

Inventor: BIENER HANS F [DE]


Patent No.: US6287552B1  Issued: 11/Sep/2001

Title: Cosmetic or dermatological topical compositions comprising dendritic polyesters

Applicant/Assignee: L'OREAL

Application No.: 09/397517   Filing Date: 17/Sep/1999

Abstract:

The present invention relates to cosmetic or dermatological compositions capable of being applied to the skin, the keratinous fibers, the nails, the semimucous membranes and/or the mucous membranes, and which includes a dendritic polyester polymer having terminal hydroxyl functional groups or the combination of such a polymer with a film-forming polymer. It also relates to methods of cosmetic or dermatological treatment using these compositions as well as the use of the compositions for the preparation of dermatological or cosmetic compositions.

Priority: FR19980011634 Applic. Date: 1998-09-17

Inventor: TOURNILHAC FLORENCE [FR]; SIMON PASCAL [FR]


Patent No.: US6287577B1  Issued: 11/Sep/2001

Title: Leave-on antimicrobial compositions which provide improved residual benefit versus gram positive bacteria

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/967972   Filing Date: 12/Nov/1997

Abstract:

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active

from about 0.05% to about 10% of an anionic surfactant

from about 0.1% to about 10% of a proton donating agent

and from about 0% to about 99.85% of water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the leave-on antimicrobial composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5

and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

Priority:

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BAKKEN THERESA ANNE [US]; CEN WEI [US]; CLAPP MANNIE LEE [US]; WARREN RAPHAEL [US]


Patent No.: US6287583B1  Issued: 11/Sep/2001

Title: Low-pH, acid-containing personal care compositions which exhibit reduced sting

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 08/969048   Filing Date: 12/Nov/1997

Abstract:

The preset invention relates to personal care compositions comprising from about 0.5% to about 80% of a surfactant, from about 0.1% to about 12% of a polymeric acid

and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0.

Priority:

Inventor: WARREN RAPHAEL [US]; CLAPP MANNIE LEE [US]


Patent No.: US6290713B1  Issued: 18/Sep/2001

Title: Flexible illuminators for phototherapy

Applicant/Assignee:

Application No.: 09/379703   Filing Date: 24/Aug/1999

Abstract:

Flexible illuminators for external phototherapy are disclosed each having at least one light generating source, preferably a plurality of light-generating sources, on a flexible substrate. The flexible substrate may be a circuit board, and the light-generating source may be surface mount LEDs. Structures for diffusing light emitted from the discrete light-generating sources and/or for transferring heat away from a skin contact surface are provided. The illuminators may be formed so as to be wrapped around an infant or a limb of an adult, or may be provided in larger configurations, such as a mat. The illuminators may be passively or actively cooled so that the skin contact surface remains below a desired temperature.

Priority:

Inventor: RUSSELL THOMAS A [US]


Patent No.: US6290938B1  Issued: 18/Sep/2001

Title: Sunscreen compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/126485   Filing Date: 30/Jul/1998

Abstract:

The present invention relates to compositions suitable for use as sunscreens which comprise a UVA sunscreen active and a carrier suitable for application to the skin. These compositions are substantially free of benzylidene camphor derivatives and provide excellent stability, efficiency, and UV protection efficacy in a safe, economical and aesthetically appealing manner. The compositions have a Sunscreen Efficiency Index of at least about 1.75, a UVA Efficacy Value of at least about 0.5, a UVA Photostability Index of at least about 0.85, a UVB Photostability Index of at least about 0.85, and a Transparency Value of less than about 10. Methods of using the compositions are also disclosed.

Priority:

Inventor: TANNER PAUL ROBERT [US]; IRWIN CHRISTOPHER [US]; O'DONOGHUE MARGARET ANN [US]


Patent No.: US6290941B1  Issued: 18/Sep/2001

Title: Powder to liquid compositions

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 09/447909   Filing Date: 23/Nov/1999

Abstract:

The invention relates to cosmetic or pharmaceutical powder-to-liquid compositions comprising hydrophobically coated silica particles into which are incorporated water and a water soluble polymer, the composition containing substantially no oil.

Priority:

Inventor: LAHANAS KONSTANTINOS M [US]; VRABIE NICOLAE [US]; SANTOS ERLINDA [US]; MIKLEAN SAUL [US]


Patent No.: US6290978B2  Issued: 18/Sep/2001

Title: Derivatives of arabinogalactan and compositions including the same

Applicant/Assignee: LAREX, INC

Application No.: 09/727035   Filing Date: 30/Nov/2000

Abstract:

Derivatized Arabinogalactan can be utilized in a variety of compositions to impart functionality without imparting negative rheological affects when the amount of the derivatized Arabinogalactan is increased in the composition. This is particularly important in the personal care industry, where it is desirable to have the flexibility to adjust the amount of derivatized Arabinogalactan depending upon the results it is desired to deliver to the user without negatively impacting the overall viscosity of the personal care composition.

Priority: US1999-300150 Applic. Date: 1999-04-27; US19980083110P Applic. Date: 1998-04-27

Inventor: MAK CHEW-HUNG [US]; WESTMAN MORTON A [US]; FINNEY MICHAEL LYNN [US]; LAMB RICHARD DALE [US]


Patent No.: US6290993B1  Issued: 18/Sep/2001

Title: Compositions containing mimosa phenolic compounds

Applicant/Assignee: E-L MANAGEMENT CORP

Application No.: 09/360884   Filing Date: 23/Jul/1999

Abstract:

The invention relates to topical cosmetic and pharmaceutical composition for enhancing collagen levels in skin cells, the compositions comprising an effective amount of a biologically active phenolic compound-containing extract, or active fraction thereof, obtainable from Mimosa pudica.

Priority:

Inventor: ANDERSON JON [US]; DECLERCQ LIEVE [BE]; COLLINS DONALD F [US]; MAMMONE THOMAS [US]; DECLERQ LIEVE [BE]; CORSTJENS HUGO A L [BE]


Patent No.: US6291478B1  Issued: 18/Sep/2001

Title: Compounds of the benzylaminodiacetamide family, compositions comprising them, preparation process and uses

Applicant/Assignee: L'OREAL

Application No.: 09/524570   Filing Date: 13/Mar/2000

Abstract:

The present application relates to novel compounds belonging to the benzylaminodiacetamide family which have good anti-irritant and soothing properties.The invention also relates to their use in a composition comprising a physiologically acceptable medium, in particular in order to prevent and/or treat certain cutaneous disorders and more particularly in order to treat sensitive skins.

Priority: FR19990003005 Applic. Date: 1999-03-11

Inventor: GALEY JEAN-BAPTISTE [FR]; DALKO MARIA [FR]


Patent No.: US6294158B1  Issued: 25/Sep/2001

Title: Cosmetic composition containing an anionic polymer and an acrylic terpolymer, and use of this composition for the treatment of keratinous material

Applicant/Assignee: L'OREAL

Application No.: 09/332005   Filing Date: 14/Jun/1999

Abstract:

The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one anionic polymer and an acrylic terpolymer, as well as to the use of these compositions for treating keratinous material.The acrylic terpolymer comprises:a) about 20 to 70% by weight of a carboxylic acid containing alpha,beta-monoethylenic unsaturation

b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), andc) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation.The invention relates in particular to leave-in hair products, such as gels, mousses, lacquers and sun compositions.

Priority: FR19980007514 Applic. Date: 1998-06-15

Inventor: DUPUIS CHRISTINE [FR]


Patent No.: US6294180B1  Issued: 25/Sep/2001

Title: Cosmetic and/or dermatological powder, process for its preparation and its uses

Applicant/Assignee: L'OREAL

Application No.: 09/436030   Filing Date: 08/Nov/1999

Abstract:

A cosmetic or dermatological powder, which comprises (i) from 5 to 60% by weight, relative to the total weight of the powder, of at least one starch modified by pregelatinization, oxidation, crosslinking, esterification or a combination thereof, (ii) from 30 to 90% by weight, relative to the total weight of the powder, of an oily phase comprising at least one oil, and (iii) at least one electrolyte, wherein the oily phase/starch weight ratio is >=1.

Priority: FR19980014029 Applic. Date: 1998-11-06

Inventor: DEMARS GWENAEELLE [FR]; KOELY SANDRINE [FR]


Patent No.: US6294532B1  Issued: 25/Sep/2001

Title: Oxindolylquinazoline derivatives as angiogenesis inhibitors

Applicant/Assignee: ZENECA LIMITED

Application No.: 09/486051   Filing Date: 03/May/2000

Abstract:

The invention relates to compounds of formula (I)and salts thereof as further defined herein, wherein ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms, and the use of such compounds and salts to inhibit the effects of VEGF and FGF, and in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Priority: EP19970401972 Applic. Date: 1997-08-22; EP19970401973 Applic. Date: 1997-08-22; EP19970401974 Applic. Date: 1997-08-22; WO1998GB02493 Applic. Date: 1998-08-19

Inventor: THOMAS ANDREW PETER [GB]; LOHMANN JEAN-JACQUES MARCEL [FR]; HENNEQUIN LAURENT FRANCOIS AND [FR]; PLE PATRICK [FR]


Patent No.: US6296835B1  Issued: 02/Oct/2001

Title: Photoprotective/cosmetic compositions comprising bis-hydroxyphenylbenzotriazole and benzazolyl/benzodiazolyl sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/589116   Filing Date: 08/Jun/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the SPF synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one bis-hydroxyphenylbenzotriazole sunscreen compound and (b) at least one second sunscreen compound which comprises at least two benzazolyl functional groups per molecule and/or at least one sunscreen compound which comprises at least one benzodiazolyl functional group per molecule, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor, advantageously formulated as an oil-in-water emulsion.

Priority: FR19990007205 Applic. Date: 1999-06-08

Inventor: CANDAU DIDIER [FR]


Patent No.: US6296858B1  Issued: 02/Oct/2001

Title: Cosmetic composition comprising an aqueous dispersion of film-forming polymer particles containing 1,2-pentanediol

Applicant/Assignee: L'OREAL

Application No.: 09/249065   Filing Date: 12/Feb/1999

Abstract:

The invention relates to the use in a cosmetic or dermatological composition which can be applied to the skin, keratin fibres, semi-mucous membranes and/or mucous membranes, of an aqueous dispersion of film-forming polymer particles combined with an antimicrobial protection system, in particular an antibacterial and/or antifungal system, comprising 1,2-pentanediol. The invention relates in particular to a make-up composition for the lips or the body.

Priority: FR19980001699 Applic. Date: 1998-02-12

Inventor: AGOSTINI ISABELLE [FR]; CUPFERMAN SYLVLE [FR]


Patent No.: US6296859B1  Issued: 02/Oct/2001

Title: Synergistic composition comprising a compound of lipoamino acid structure and a water lily extract

Applicant/Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC

Application No.: 09/263091   Filing Date: 05/Mar/1999

Abstract:

Composition characterized in that it comprises, as active principle, at least one compound of formula (I):its topically acceptable salts,which R represents the characterizing chain of a saturated or unsaturated, linear or branched fatty acid containing from 3 to 30 carbon atoms, R1 represents the characterizing chain of an amino acid and m is between 1 and 5, and the constituents of at least one extract and/or of at least one tincture from plants of the Nympheacea family. The composition is useful in cosmetics.

Priority: FR19980002828 Applic. Date: 1998-03-09

Inventor: STOLTZ CORINNE [FR]


Patent No.: US6296861B1  Issued: 02/Oct/2001

Title: Treatment of skin damage using conjugated linoleic acid and ascorbyl fatty acid esters

Applicant/Assignee:

Application No.: 09/563169   Filing Date: 02/May/2000

Abstract:

A synergistic combination of conjugated linoleic acid and fatty acid esters of ascorbic acid is topically applied to treat skin damage, such as contact dermatitis, atopic dermatitis, xerosis, eczema, rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 1% to about 25% by weight of a CLA preparation containing 9,11-octadecadienoic acid and 10,12-octadecadienoic acid, and from about 0.5% to about 15% by weight of a saturated fatty acid ester of ascorbic acid such as ascorbyl palmitate.

Priority: US19990132282P Applic. Date: 1999-05-03

Inventor: PERRICONE NICHOLAS V [US]


Patent No.: US6298864B1  Issued: 09/Oct/2001

Title: Device for applying a film-forming composition

Applicant/Assignee: L'OREAL

Application No.: 09/239886   Filing Date: 29/Jan/1999

Abstract:

A device for forming a peel-off film in situ includes a film-forming composition, a receptacle containing the composition, an applicator including an applicator element, and a wiper member inside the receptacle. The applicator element and the wiper member are organized in such a manner that, after wiping, and on being moved in contact with the skin, the applicator element leaves a film of film-forming composition which, once dry, can be peeled off and has a density per unit mass that preferably lies in the range 1 mg/cm2 to 15 mg/cm2. The film-forming composition preferably includes at least one active substance for cosmetic and/or pharmaceutical treatment of the skin.

Priority: FR19980001064 Applic. Date: 1998-01-30

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6303108B1  Issued: 16/Oct/2001

Title: Solid warming pulverulent composition to be hydrated for caring for or cleaning the skin

Applicant/Assignee: L'OREAL

Application No.: 09/332900   Filing Date: 15/Jun/1999

Abstract:

A warming and foaming anhydrous pulverulent composition, which is capable of being, hydrated, which comprises cosmetically acceptable powder and a binder, where the powder comprises solid particles of expanded polymers and the binder comprises an effective amount of an agent capable of giving off heat during hydration. The composition may be used, for example, for cleaning and/or caring for human skin.

Priority: FR19980007518 Applic. Date: 1998-06-15

Inventor: ROULIER VERONIQUE [FR]; DAUBIGE THERESE [FR]


Patent No.: US6303109B1  Issued: 16/Oct/2001

Title: Body cleansing agent

Applicant/Assignee: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

Application No.: 09/380881   Filing Date: 12/Oct/1999

Abstract:

The invention relates to lipid soluble, water insoluble cosmetic or dermatological active substances which can be included in body cleansing agents in the form of an aqueous preparation with at least 5 wt. % water soluble ionic or non-ionic surfactant content by solubilization of the active substances with a polar lipid in lipid-surfactant mixed micelles or liquid crystals or by microemulsification with a nonpolar lipid, wherein the emulsion particles have a diameter which is less than 500 nm. Said agents are also characterized by enhanced skin penetration by the active substances.

Priority: DE19971010149 Applic. Date: 1997-03-12; WO1998EP01174 Applic. Date: 1998-03-03

Inventor: FOERSTER THOMAS [DE]; HOLLENBROCK MARTINA [DE]; SCHOLZ WOLFHARD [DE]; PITTERMANN WOLFGANG [DE]; SCHMITT MICHAEL [DE]


Patent No.: US6303139B1  Issued: 16/Oct/2001

Title: Dietary product effective to combat oxidative stress and cell decay

Applicant/Assignee: IDI FARMACEUTICI S.P.A

Application No.: 09/355558   Filing Date: 30/Jul/1999

Abstract:

The present invention relates to a dietary product comprising ubiquinone, stabilized vitamin E, phospholipids, selenuim in an organic form and L-methionin, which is effective to combat cell oxidative stress even to the extreme consequences thereof, for example cell decay, acquired and/or congenital immunodeficiency or other alterations in the immune system. The dietary product object of the present invention is also effective as a coadjutant in the treatment of apoptosis, in mutagenesis and/or carcinogenesis, in infectious diseases of viral or bacterial origin or those deriving from other external pathogens, in myelinic and skin diseases, in cardiovascular diseases and in allergies.

Priority: IT1997RM00045 Applic. Date: 1997-01-31; WO1998IT00015 Applic. Date: 1998-02-02

Inventor: PASSI SIRO [IT]; GUARNIERI DECIMO [IT]; CARBONE SANTO [IT]


Patent No.: US6303141B1  Issued: 16/Oct/2001

Title: Transdermally administrable medicament with ACE inhibitors

Applicant/Assignee: HEXAL AG

Application No.: 09/407348   Filing Date: 29/Sep/1999

Abstract:

The invention relates to a transdermal system containing at least one angiotensin-converting enzyme inhibitor.

Priority: DE19951012181 Applic. Date: 1995-03-31

Inventor: FISCHER WILFRIED [DE]; KLOKKERS KARIN [DE]; SENDL-LANG ANNA [DE]


Patent No.: US6303644B1  Issued: 16/Oct/2001

Title: Proton pump inhibitor in therapeutic combination with antibacterial substances

Applicant/Assignee: BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH

Application No.: 09/463390   Filing Date: 27/Jan/2000

Abstract:

The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially active compounds.

Priority: EP19970112795 Applic. Date: 1997-07-25; WO1998EP04553 Applic. Date: 1998-07-21

Inventor: TUCH KLAUS [DE]


Patent No.: US6306376B1  Issued: 23/Oct/2001

Title: Use of arbutin monoesters as depigmenting agents

Applicant/Assignee: L'OREAL

Application No.: 09/112001   Filing Date: 08/Jul/1998

Abstract:

Arbutin monoesters are employed in a composition for topical application, as a depigmenting and/or bleaching agent for human skin, hair and/or head hair.The invention relates to a method of manufacturing a composition of at least one arbutin monoester in a physiologically acceptable medium for depigmenting and/or bleaching human skin, hair and/or head hair.

Priority: FR19970008674 Applic. Date: 1997-07-08

Inventor: PHILIPPE MICHEL [FR]


Patent No.: US6306411B1  Issued: 23/Oct/2001

Title: Cosmetic composition comprising an aqueous dispersion of film-forming polymer and an aqueous suspension of organopolysiloxane

Applicant/Assignee: L'OREAL S.A

Application No.: 09/568476   Filing Date: 10/May/2000

Abstract:

The invention relates to a composition to be applied to the skin and superficial body growths, comprising an aqueous dispersion of particles of film-forming polymer and an aqueous suspension of particles of at least partially crosslinked solid elastomeric polyorganosiloxane. The invention also relates to a process for caring for or making up keratin substances, which comprises applying the composition to the keratin substances. The composition makes it possible to obtain a film which has good staying power, is water-resistant and feels comfortable.

Priority: FR19990005999 Applic. Date: 1999-05-11

Inventor: JAGER LEZER NATHALIE [FR]


Patent No.: US6309656B1  Issued: 30/Oct/2001

Title: Cosmetic and skin protective compositions

Applicant/Assignee:

Application No.: 09/386235   Filing Date: 31/Aug/1999

Abstract:

A hair and scalp formulation based on a peroxidase enzyme and synergistic yeast extract therefore. It entails a chemically-inert carrier material, a germicidal/preservative agent, and a metal chelating agent. A skin protective formulation based on peroxidase enzyme and yeast extract. It entails a polymer carrier, a fatty acid emollient, a co-emulsifier of an amino acid complex essential to a fatty acid

an emulsifying agent

a skin healing agent, and a germicidal surfactant. An aqueous formulation adapted for topical hair rinsing consisting of a peroxidase enzyme, a yeast extract adapted to enhance the activity of the enzyme and a cationic hair conditioning agent selected from water-soluble thickening resins.

Priority: US19980110155P Applic. Date: 1998-11-27

Inventor: PUGLIESE PETER T [US]; PUGLIESE STEVEN M [US]


Patent No.: US6312673B2  Issued: 06/Nov/2001

Title: Photostabilized sunscreen compositions comprising dibenzoylmethane compounds and benzylidenecamphor-substituted silanes/organosiloxanes

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/761827   Filing Date: 18/Jan/2001

Abstract:

Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective amount of at least one dibenzoylmethane UV-screening compound, and (ii) an amount of at least one silane or organosiloxane substituted by a benzylidenecamphor functional group effective to photostabilize said at least one dibenzoylmethane UV-screening compound (i).

Priority: FR19980008937 Applic. Date: 1998-07-10; US1999-350910 Applic. Date: 1999-07-12

Inventor: RICHARD HERVE [FR]; FORESTIER SERGE [FR]


Patent No.: US6312698B1  Issued: 06/Nov/2001

Title: Anti-fungal formulation active against a broad spectrum of dermatophytoses

Applicant/Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Application No.: 09/537148   Filing Date: 29/Mar/2000

Abstract:

The invention provides a novel anti-fungal formulation active against a broad spectrum of dermatophytoses, said formulation comprising at least about 1% by weight of oil extracted from Rabdosia melissoides and one or more vegetable oils, solvents and additives.

Priority:

Inventor: SHAHI SUSHIL KUMAR [IN]; SHUKLA AMRITESH CHANDRA [IN]; DIKSHIT ANUPAM [IN]; BAJAJ ASHOK KUMAR [IN]; SINGH ANIL KUMAR [IN]; KUMAR SUSHIL [IN]


Patent No.: US6312702B2  Issued: 06/Nov/2001

Title: Solid cosmetic composition free of fillers, containing low amounts of gelling agents

Applicant/Assignee: L'OREAL

Application No.: 09/206977   Filing Date: 08/Dec/1998

Abstract:

The present invention relates to a solid composition for topical application, which is free of fillers, containing, in an aqueous phase, less than 20% of the total weight of the composition of a hydrophillic gelling system having the combination of at least 2% by weight of kappa-carrageenan, relative to the total weight of the composition, and at least one hydrocolloid chosen from xanthan gum and cellulose derivatives which are soluble in hot water.

Priority: FR19970016174 Applic. Date: 1997-12-19

Inventor: ROULIER VERONIQUE [FR]; QUEMIN ERIC [FR]


Patent No.: US6312703B1  Issued: 06/Nov/2001

Title: Compressed lecithin preparations

Applicant/Assignee: LECIGEL, LLC

Application No.: 09/245289   Filing Date: 05/Feb/1999

Abstract:

The present invention relates to compositions primarily comprised of phospholipids, commercially known as lecithin, wherein the phospholipids form a solid mass-a liquid crystal phospholipid (LCP)-without the use of emulsifiers or other ingredients which are typically used as carriers for phospholipids. The invention also relates to the methods for making the phospholipid compositions. More particularly, the invention relates to a physical form of phospholipids and its use as a topical cosmetic skin bar, as a nutrient supplement or as a pharmaceutical dosage form if taken orally. Regardless of the exact shape of the new phospholipid composition, it comprises an amount of phospholipid equal to at least about 20% by weight of the total product. The new composition of the phospholipids appears as a solid which is produced by subjecting granular or powdered phospholipids to high levels of pressure which result in the formation of the solid phospholipid composition.

Priority: US19980073990P Applic. Date: 1998-02-06

Inventor: ORTHOEFER FRANK T [US]


Patent No.: US6316011B1  Issued: 13/Nov/2001

Title: End modified thermal responsive hydrogels

Applicant/Assignee: MADASH, LLC

Application No.: 09/368440   Filing Date: 04/Aug/1999

Abstract:

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer

and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosities in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

Priority: US19980095330P Applic. Date: 1998-08-04; US19980097741P Applic. Date: 1998-08-24

Inventor: RON EYAL S [US]; BROMBERG LEV [US]; TEMCHENKO MARINA [US]


Patent No.: US6316021B1  Issued: 13/Nov/2001

Title: Extensible mask including an adhesive matrix that can be stretched at least in the wet state

Applicant/Assignee: L'OREAL

Application No.: 09/534025   Filing Date: 24/Mar/2000

Abstract:

The invention relates to a mask for the face or the body, which mask comprises a backing sheet coated on one of its faces with an adhesive matrix containing a permanent adhesive that adheres both to dry skin and to wet skin, at least one of the backing sheet and the adhesive matrix containing at least one active ingredient serving to exert a specific action on the skin. The adhesive matrix is stretchable at least in the wet state, in order to enable the mask to be adapted to fit the shape of the face or of the portion of the body to be treated, the backing sheet being chosen to be capable, at least in the wet state, of stretching so as to accompany the deformations in the adhesive matrix.

Priority: FR19990004094 Applic. Date: 1999-04-01

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6319507B1  Issued: 20/Nov/2001

Title: Agar gel bead composition and method

Applicant/Assignee: KOBO PRODUCTS, INC

Application No.: 09/431742   Filing Date: 01/Nov/1999

Abstract:

Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

Priority: WO1998IB00977 Applic. Date: 1998-05-01; US1997-850167 Applic. Date: 1997-05-02

Inventor: DELRIEU PASCAL E [FR]; DING LI [FR]


Patent No.: US6319508B1  Issued: 20/Nov/2001

Title: Anhydrous cosmetic composition containing a fatty phase and pro-liposomes

Applicant/Assignee: L'OREAL

Application No.: 09/630957   Filing Date: 02/Aug/2000

Abstract:

An anhydrous cosmetic makeup composition contains in addition to a fatty phase formed from oils, fatty bodies and surfactants, and optionally waxes, a vesicular lipidic phase that contains at least one ionic or nonionic amphiphilic lipid and optionally additives. The anhydrous composition also preferably contains at least one cosmetically and/or dermopharmaceutically active material. In the presence of an aqueous phase these compositions release vesicles of the vesicular lipidic phase and potentialize the activity of the cosmetically and/or dermopharmaceutically active material of the composition.

Priority: FR19910011985 Applic. Date: 1991-09-30; US1992-954362 Applic. Date: 1992-09-29

Inventor: RIBIER ALAIN [FR]; SIMMONET JEAN-THIERRY [FR]; MIGUEL DOLORES [FR]


Patent No.: US6322798B1  Issued: 27/Nov/2001

Title: Cosmetic and/or dermatological composition with a hydrophilic carrier and vitamin C which can be mixed immediately before use

Applicant/Assignee: L'OREAL

Application No.: 08/417135   Filing Date: 04/Apr/1995

Abstract:

A topical composition separately containing a hydrophilic carrier and a solid which are intended to be mixed immediately before use, the solid being powdered ascorbic acid and the carrier containing an aqueous medium and at least one hydrophilic gelling agent, the carrier being capable of withstanding the introduction of an acidic compound. In a preferred embodiment, the carrier (L) is packaged in a container (1) closed with a cap (3,6) containing ascorbic acid (P), a perforable and/or detachable separator (5) being provided between the acid and the carrier.

Priority: FR19940003982 Applic. Date: 1994-04-05

Inventor: CANDAU DIDIER [FR]; COLLIN NATHALIE [FR]; QUEMIN ERIC [FR]


Patent No.: US6322799B1  Issued: 27/Nov/2001

Title: Benefit agent compositions comprising mixtures of alpha-hydroxy esters

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/293752   Filing Date: 16/Apr/1999

Abstract:

The present invention relates to skin care or personal wash cleanser compositions comprising mixtures of short and long-chain alpha-hydroxy acid esters in order to obtain long term benefit of shorter esters while masking short term drying effect of short chain esters.

Priority: US1997-898237 Applic. Date: 1997-07-22

Inventor: ILARDI LEONORA [US]; ARONSON MICHAEL PAUL [US]; WEINKAUF RONNI LYNN [US]


Patent No.: US6322801B1  Issued: 27/Nov/2001

Title: Personal care articles

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/444343   Filing Date: 19/Nov/1999

Abstract:

The present invention relates to a substantially dry, disposable personal care article suitable for cleansing wherein the article comprises: a) a water insoluble substrate comprising a first layer that includes a nonwoven ply and a polymeric net arranged with the nonwoven ply

and b) a cleansing component disposed adjacent to said first layer, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant. The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to the water insoluble substrate, wherein the therapeutic benefit component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit agent in addition to or in lieu of the cleansing component. These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair.

Priority: US19990146815P Applic. Date: 1999-08-02

Inventor: LORENZI MARC PAUL [GB]; SMITH III EDWARD DEWEY [US]


Patent No.: US6325990B1  Issued: 04/Dec/2001

Title: Film forming composition for spraying on the skin

Applicant/Assignee: LAFON LABORATOIRE L

Application No.: 09/051719   Filing Date: 07/May/1998

Abstract:

A composition is intended to form on the skin, by spraying from an erasol can, a film for the transdermal administration of an active agent, and the composition contains 0.01-10% by weight of lipophilic vitamins, hormones, nicotine, corticoids, retinoids, antimycosic agents, anistetics, anolgesics, or anti cancer agents for the skin, 0.5 to 25% by weight of an adhesive polysiloxane composition, 5 to 25% by weight of an absorption promoter, 25 to 95% by weight of a volatile solvent containing at least a volatile silicone, and 0.5 to 50% by weight of pressurized propellant gas, and the composition is substantially free from water.

Priority: FR19950012393 Applic. Date: 1995-10-20; WO1996FR01628 Applic. Date: 1996-10-17

Inventor: LAURENT PHILIPPE [FR]


Patent No.: US6325994B1  Issued: 04/Dec/2001

Title: Cosmetic composition comprising a styrene/acrylate copolymer and a fatty phase

Applicant/Assignee: L'OREAL S.A

Application No.: 09/477823   Filing Date: 05/Jan/2000

Abstract:

A composition for topical application comprising, in a cosmetically, dermatologically, hygienically or pharmaceutically acceptable support, at least one fatty phase and at least one lipophilic polymer, wherein the lipophilic polymer is a tert-butylstyrene/C1-C10 alkyl methacrylate/C1-C10 alkyl acrylate copolymer. The composition makes it possible to obtain a film which has very good staying power and good transfer-resistance properties. The film obtained is particularly resistant to water, to rubbing, for example with the fingers or against clothing, to perspiration and to sebum.

Priority: FR19990000055 Applic. Date: 1999-01-06

Inventor: COLLIN NATHALIE [FR]; BODELIN SOPHIE [FR]


Patent No.: US6326012B1  Issued: 04/Dec/2001

Title: Transfer-resistant make-up or care composition based on isoparaffins and functionalized synthetic waxes

Applicant/Assignee: L'OREAL

Application No.: 09/371007   Filing Date: 10/Aug/1999

Abstract:

A solid transfer-resistant make-up or care composition containing, in a physiologically acceptable medium:at least one volatile hydrocarbon based oil, andas a hardening agent, at least one functionalized synthetic wax having at least one hydroxyl or carboxyl functional group and having a melting point of between 75 DEG C. and 120 DEG C. andHansen Solubility Parameters, deltad, deltah such that:wherein

Priority: FR19980010255 Applic. Date: 1998-08-10

Inventor: ARNAUD PASCAL [FR]; AUGUSTE FREDERIC [FR]


Patent No.: US6326013B1  Issued: 04/Dec/2001

Title: Cosmetic composition in the form of an emulsion comprising a dispersion of surface-stabilized polymer particles in a liquid fatty phase

Applicant/Assignee: L'OREAL

Application No.: 09/399734   Filing Date: 20/Sep/1999

Abstract:

A composition for topical application, comprising a liquid fatty phase and an aqueous phase, one of the phases being dispersed in the other phase, and said liquid fatty phase comprising surface-stabilized polymer particles in an amount sufficient to confer transfer-free properties to the composition.

Priority: FR19980011694 Applic. Date: 1998-09-18

Inventor: LEMANN PATRICIA [FR]; DE LA POLERIE VALERIE [FR]


Patent No.: US6326014B1  Issued: 04/Dec/2001

Title: Use of oxamate derivatives as depigmenting agents

Applicant/Assignee: L, OREAL

Application No.: 09/572401   Filing Date: 16/May/2000

Abstract:

The invention relates to the use of oxamate derivatives in a composition, as agents for depigmenting and/or bleaching human skin, head hair and/or other hairs. The invention also relates to a process for depigmenting and/or bleaching the skin, head hair and/or other hairs, which includes applying a composition comprising oxamate derivatives to human skin, head hair and/or other hairs.

Priority: FR19970010657 Applic. Date: 1997-08-26; US1998-140532 Applic. Date: 1998-08-26

Inventor: TULOUP REMY [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6326160B1  Issued: 04/Dec/2001

Title: Microprocessors for use in a device for predicting physiological values

Applicant/Assignee: CYGNUS, INC

Application No.: 09/405976   Filing Date: 27/Sep/1999

Abstract:

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

Priority: US1999-241929 Applic. Date: 1999-02-01; US1998-198039 Applic. Date: 1998-11-23; US1998-163856 Applic. Date: 1998-09-30

Inventor: DUNN TIMOTHY C [US]; JAYALAKSHMI YALIA [US]; KURNIK RONALD T [US]; LESHO MATTHEW J [US]; OLIVER JONATHAN JAMES [US]; POTTS RUSSELL O [US]; TAMADA JANET A [US]; WATERHOUSE STEVEN RICHARD [US]; WEI CHARLES W [US]


Patent No.: US6328983B1  Issued: 11/Dec/2001

Title: Use of a silicone gum to stabilize ascorbic acid, and novel compositions comprising these components

Applicant/Assignee: L'OREAL

Application No.: 09/408448   Filing Date: 29/Sep/1999

Abstract:

The present invention relates to the use of a silicone gum to stabilize ascorbic acid or one of its esters or salts in a topical composition and to novel compositions comprising these components and having a pH of from 4 to 7. These compositions can be used in the fields of cosmetology, dermatology and veterinary medicine.

Priority: FR19980012156 Applic. Date: 1998-09-29

Inventor: AFRIAT ISABELLE [FR]


Patent No.: US6329353B1  Issued: 11/Dec/2001

Title: Clear personal care formulations containing quaternary ammonium compounds and other nitrogen-containing compounds

Applicant/Assignee: GOLDSCHMIDT CHEMICAL CORPORATION

Application No.: 09/438694   Filing Date: 11/Nov/1999

Abstract:

A composition formulated from a primary anionic surfactant

optionally a secondary surfactant and/or a resin

and a nitrogen-containing compound of the structural formula:wherein R is a saturated, linear, branched or cyclic alkyl or aryl group containing 12 to 22 carbon atoms, with the proviso that R contains at least 80% of a single chain length and R is not lanolin, wheat germ or other natural broad-based chain distribution oil, R1 is a saturated or unsaturated, linear, branched or cyclic alkyl or aryl group containing 1 to 6 carbon atoms and may contain one or more hydroxyl groups, R2 is selected from the group consisting of hydrogen, methyl, ethyl and benzyl

and A- is a monovalent anion.

Priority: WO1999US10405 Applic. Date: 1999-05-12

Inventor: DALRYMPLE DAMON M [US]; MANNING MONNA [US]; MERZ FRANK [DE]


Patent No.: US6331305B1  Issued: 18/Dec/2001

Title: Water-in-oil cosmetic compositions comprising willow bark extract

Applicant/Assignee: THE PROCTER & GAMBLE CO

Application No.: 09/202312   Filing Date: 05/Apr/1999

Abstract:

Cosmetic compositions for topical application to the skin are in the form of a water-in-oil emulsion and comprise (a) continuous oil phase comprising a mixture of volatile silicone and non-volatile silicone

(b) discontinuous aqueous phase

and (c) willow bark extract.

Priority: GB19960013524 Applic. Date: 1996-06-27; GB19960019110 Applic. Date: 1996-09-12; WO1997US09700 Applic. Date: 1997-06-23

Inventor: SANG CHUNE [GB]


Patent No.: US6331306B1  Issued: 18/Dec/2001

Title: Composition in the form of a water-in-oil emulsion having a changing shear rate

Applicant/Assignee: L'OREAL

Application No.: 09/343527   Filing Date: 30/Jun/1999

Abstract:

A cosmetic or dermatological composition, comprising:an aqueous phase dispersed in an oily phase with a silicone emulsifying agent, wherein the viscosity of the composition, measured with a Rheomat 180 viscometer at a shear rate of 200 s-1 and at 25 DEG C., ranges from 3 Pa.s (30 poises) to 20 Pa.s (200 poises), the aqueous phase constituting at least 78% by weight with respect to the total weight of the composition with the water of the aqueous phase constituting at least 65% of the total weight of the composition, and the emulsifying agent consisting of the dimethicone copolyol of formula (I):wherein R1 is

Priority: FR19980008418 Applic. Date: 1998-07-01

Inventor: AFRIAT ISABELLE [FR]; BOULIER VIRGINIE [FR]


Patent No.: US6331307B1  Issued: 18/Dec/2001

Title: O/W emulsion with a high electrolyte content and its use in dermocosmetics, in particular for treating irritation and/or sensitive skin phenomena

Applicant/Assignee: L'OREAL

Application No.: 09/617038   Filing Date: 14/Jul/2000

Abstract:

A composition in the form of an O/W emulsion comprising at least 2% by weight, relative to the total weight of the composition, of at least one water-soluble metal salt, and from 2-4.5% by weight, relative to the total weight of the composition, of a suitable emulsifying system, excluding compositions comprising 1% by weight of a gelling agent consisting of a combination of a polyacrylamide, C13-C14 isoparaffin and laureth-7 (CTFA).

Priority: FR19960012450 Applic. Date: 1996-10-11; US1997-949685 Applic. Date: 1997-10-14

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]; GAGNEBIEN DIDIER [US]


Patent No.: US6331535B1  Issued: 18/Dec/2001

Title: Retinyl carbonate derivatives, preparation process and uses

Applicant/Assignee: L'OREAL

Application No.: 09/580833   Filing Date: 30/May/2000

Abstract:

The present invention relates to novel retinol derivatives having the formula (I):and to processes for preparing them. The invention also relates to the use of these compounds in or for the preparation of compositions intended for treating conditions of the skin or scalp, for example in preventing or combating acne and/or chronological or actinic ageing of the skin.

Priority: FR19990006872 Applic. Date: 1999-06-01

Inventor: TULOUP REMY [FR]; DALKO MARIA [FR]; RUBINSTENN GILLES [FR]


Patent No.: US6333026B1  Issued: 25/Dec/2001

Title: Use of an indigoid compound in a cosmetic composition, in particular a make-up composition, in order to confer on it antimicrobial properties and the property of lengthy hold over time

Applicant/Assignee: L'OREAL

Application No.: 09/458207   Filing Date: 10/Dec/1999

Abstract:

The invention relates to the use of at least one compound of formula:in which R1 and R'1 are C1-C18 alkyl radicals which are optionally substituted by one or more halogens or hydroxyls and/or are interrupted by one or more heteroatoms, and R2 to R5 and R'2 to R'5 are hydrogen or halogen atoms, hydroxyl radicals or C1-C6 alkyl, alkyloxy, acyl or acyloxy radicals, in a cosmetic composition, in particular a make-up composition, in order to confer on it antimicrobial properties and properties of lengthy hold over time and/or of non-migration and/or of freedom from transfer and/or of non-formation of streaks.The invention also relates to a cosmetic composition, in particular a make-up composition and especially an eyeshadow, comprising such a compound in a silicone binder.

Priority: FR19980015693 Applic. Date: 1998-12-11

Inventor: LEMANN PATRICIA [FR]


Patent No.: US6333027B1  Issued: 25/Dec/2001

Title: Composition for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis and eczema and symptoms thereof

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER PRODUCTS, INC

Application No.: 09/556735   Filing Date: 21/Apr/2000

Abstract:

A composition that is useful for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis, and eczema and/or the symptoms associated therewith, and is non-stinging to the eyes is disclosed. The composition contains from about 0.5 weight percent to about 16 weight percent of at least one amphoteric surfactant

from about 1 weight percent to about 10 weight percent of at least one anionic surfactant

from about 0.1 weight percent to about 10 weight percent of at least one non-ionic surfactant

and from about 0.1 percent to about 15 percent active ingredient selected from Undecylenamidopropylbetaine, Undecylenic Acid, and mixtures thereof. A method for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis, and eczema and/or the symptoms associated therewith including topically applying an effective amount of the composition to the area desired is also disclosed.

Priority: US19990132986P Applic. Date: 1999-05-07

Inventor: HOPKINS JOHN [GB]; KHAIAT ALAIN [SG]; MANIGBAS NOEL D [PH]; PING ELIZABETH WEN [CN]; BAKER REX J [CN]


Patent No.: US6333042B1  Issued: 25/Dec/2001

Title: Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/584724   Filing Date: 01/Jun/2000

Abstract:

A substance P antagonist is used in a cosmetic composition to treat sensitive skin. More specifically, a cosmetic composition containing a substance P antagonist is used to prevent and/or combat skin irritations, desquamation, erythermas, sensations of dysesthesia/overheating, or pruritus of the skin.

Priority: FR19940005537 Applic. Date: 1994-05-05; US1997-881272 Applic. Date: 1997-06-24; US1994-358562 Applic. Date: 1994-12-14

Inventor: DE LA CHARRIERE OLIVIER [FR]; BRETON LIONEL [FR]


Patent No.: US6333054B1  Issued: 25/Dec/2001

Title: Topical, non-cytotoxic, antimicrobial hydrogel with thixotropic properties

Applicant/Assignee: AMUCHINA S.P.A

Application No.: 09/422327   Filing Date: 21/Oct/1999

Abstract:

A thixotropic, non-cytotoxic, topical hydrogel that contains a proven safe and effective, broad spectrum, antimicrobial agent based on a unique electrolytically derived sodium hypochlorite solution.

Priority:

Inventor: ROGOZINSKI WALLACE [US]


Patent No.: US6335022B1  Issued: 01/Jan/2002

Title: Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/459580   Filing Date: 13/Dec/1999

Abstract:

The present invention relates to a nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to 45 DEG C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate, lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Priority: FR19980015949 Applic. Date: 1998-12-17

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6335025B1  Issued: 01/Jan/2002

Title: Water-in-oil emulsion and use thereof in a cosmetic composition

Applicant/Assignee: L'OREAL

Application No.: 09/692361   Filing Date: 20/Oct/2000

Abstract:

The present invention relates to a water-in-oil emulsion, in particular a cosmetic emulsion, comprising (i) an alkylpolyglycoside having an HLB of less than 7, and (ii) at least one volatile oil. The alkyl chain of the alkylpolyglycoside preferably contains from 14 to 24 carbon atoms and can be in particular an unsaturated linear chain and/or a branched chain, and more particularly an oleyl or isostearyl chain. The volatile oil can be chosen in particular from branched-chain hydrocarbon-based oils and volatile silicone oils, and mixtures thereof. The emulsion obtained is stable and feels fresh when applied. It can be used in particular for caring for the skin, the nails and the hair, for removing make-up from and/or for cleansing the skin, and/or for making up the skin.

Priority: FR19990013146 Applic. Date: 1999-10-21

Inventor: LORANT RALUCA [FR]


Patent No.: US6335388B1  Issued: 01/Jan/2002

Title: Prolamine-plant polar lipid composition, its method of preparation and applications thereof

Applicant/Assignee: LAVIPHARM LABORATORIES INC

Application No.: 09/165846   Filing Date: 02/Oct/1998

Abstract:

Prolamine-plant polar lipid compositions are provided, said compositions including a mixture of a prolamine, a plant polar lipid, at least one polyalcohol in a hydro-alcoholic solution, and an active agent, wherein the composition forms a substantially homogeneous dispersion with skin adhesive properties

wherein the dispersion forms a film and wherein the film contains a gradient of concentrations of the active agent.

Priority: US19970060897P Applic. Date: 1997-10-03

Inventor: FOTINOS SPIROS [GR]


Patent No.: US6336926B1  Issued: 08/Jan/2002

Title: Electrosurgical system

Applicant/Assignee: GYRUS MEDICAL LIMITED

Application No.: 09/484225   Filing Date: 18/Jan/2000

Abstract:

An electrosurgical system comprises a radio frequency generator (1), an electrosurgical instrument (E1), and a fluid enclosure (42). The generator (1) has a radio frequency output for delivery of power to the electrosurgical instrument (E1) when immersed in an electrically-conductive fluid. The electrosurgical instrument (E1) has an electrode assembly (32) at the distal end thereof, the electrode assembly comprising a tissue treatment electrode (34), and a return electrode (38) axially spaced therefrom in such a manner as to define, in use, a conductive fluid path that completes an electrical circuit between the tissue treatment electrode and the return electrode. The fluid enclosure (42) is adapted to surround an operation site on the skin of a patient or an incision leading to a cavity surgically created within the patient's body. The fluid enclosure (42) includes sealing means (44) for sealing against the patient's tissue, and the fluid enclosure includes at least one port (50a, 52a) through which the electrosurgical (E1) is insertable, and through which the electrically-conductive fluid can enter and/or leave the enclosure.

Priority: GB19990000964 Applic. Date: 1999-01-15

Inventor: GOBLE NIGEL M [GB]


Patent No.: US6336935B1  Issued: 08/Jan/2002

Title: Disposable thermal body wrap

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/397338   Filing Date: 15/Sep/1999

Abstract:

The thermal body wraps of the present invention comprise a unified laminate structure having at least one continuous layer of a flexible material having a substantially rectangular, dog bone-like shape and having a first side, a second side, a first end, a second end, a plurality of heat cells, and means for releasably attaching the thermal body wrap to a user's body. Preferably the heat cells are placed into positions fixed within or to the unified structure of the thermal body wraps, relative to each other and sufficiently close to provide controlled, sustained, and uniform heat to the body or body part of the user.

Priority:

Inventor: DAVIS LEANE KRISTINE [US]; MCCARTHY NANCY JEAN [US]


Patent No.: US6337066B1  Issued: 08/Jan/2002

Title: Cosmetic and/or dermatological composition based on ascorbic acid in powder form

Applicant/Assignee: L'OREAL

Application No.: 09/201090   Filing Date: 30/Nov/1998

Abstract:

A cosmetic and/or dermatological composition in the form of a powder containing pulverulent ascorbic acid, starch and at least one anionic surfactant. In a preferred embodiment, the composition also contains a water-soluble polymer. The inventive powder composition has good foaming properties when it is moistened with water, and it is useful in particular for cleansing and/or treating the skin. The composition according to the invention is preferably contained in a sponge which is moistened with water and applied directly to the skin.

Priority: FR19970015860 Applic. Date: 1997-12-15

Inventor: JACQUIER ISABELLE [FR]


Patent No.: US6337076B1  Issued: 08/Jan/2002

Title: Method and composition for the treatment of scars

Applicant/Assignee: SG LICENSING CORPORATION

Application No.: 09/441138   Filing Date: 17/Nov/1999

Abstract:

A method and composition for treating hypertrophic scars so as to reduce the size and approve the appearance of scars comprises applying to the scar a composition comprising a film-forming carrier such as a Collodion which contains one or more active ingredients such as a topical steroid, silicone gel and vitamin E. Novel compositions using the Collodion film-forming carrier are also useful to treat a variety of adverse skin disorders.

Priority:

Inventor: STUDIN JOEL R [US]


Patent No.: US6337077B1  Issued: 08/Jan/2002

Title: Composition with a continuous aqueous phase containing L-2-oxothiazolidine-4-carboxylic acid

Applicant/Assignee: L'OREAL

Application No.: 09/522106   Filing Date: 09/Mar/2000

Abstract:

A composition containing a continuous aqueous phase comprising L-2-oxothiazolidine-4-carboxylic acid, at least one sequestering agent and at least one neutralizing agent, the said neutralizing agent being present in an amount which is sufficient to adjust the pH of the aqueous phase of the composition to a value of between 5 and 8. The combination of the sequestering agent and the neutralizing agent stabilizes the L-2-oxothiazolidine-4-carboxylic acid, in particular with respect to thermal degradation, and thus prevents yellowing of the composition and the formation of unpleasant odors.

Priority: FR19990003476 Applic. Date: 1999-03-19

Inventor: CHEVALIER VERONIQUE [FR]; QUEST MELANIE [FR]


Patent No.: US6337086B1  Issued: 08/Jan/2002

Title: Pressure sensitive adhesive compositions for transdermal drug delivery devices

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/245687   Filing Date: 06/Feb/1999

Abstract:

A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin

and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer. The silicone pressure sensitive adhesive comprises silicone resin copolymer and a polydiorganosiloxane and has a silanol concentration in the range of between about 8000 and about 13,000 ppm. The present invention also relates to methods for producing the above silicone pressure sensitive adhesive compositions.

Priority:

Inventor: KANIOS DAVID PAUL [US]; MANTELLE JUAN [US]; NARTKER LINDA SUE [US]; RAUL VICTOR ALBERT [US]; ULMAN KATHERINE LYNN [US]


Patent No.: US6337320B1  Issued: 08/Jan/2002

Title: Reparatives for ultraviolet radiation skin damage

Applicant/Assignee: THIONE INTERNATIONAL, INC

Application No.: 08/728948   Filing Date: 11/Oct/1996

Abstract:

A composition of L-glutathione (reduced) and selenium and an epidermal growth factor in a topical carrier and method of using the composition to reduce and repair ultraviolet radiation-induced skin damage, both acute injury (sunburn) and chronic damage (photoaging and cutaneous malignancies).

Priority:

Inventor: HERSH THEODORE [US]; WARSHAW MICHAEL A [US]


Patent No.: US6338839B1  Issued: 15/Jan/2002

Title: Transfer-resistant make-up or care composition containing a volatile linear silicone

Applicant/Assignee: L'OREAL

Application No.: 09/371531   Filing Date: 10/Aug/1999

Abstract:

A transfer-resistant make-up or care composition, comprising:a fatty phase, anda volatile solvent comprising a linear decamethyltetrasiloxane and at least one additional solvent which has an evaporation speed that is greater than the evaporation speed of the linear decamethyltetrasiloxane.

Priority: FR19980010256 Applic. Date: 1998-08-10; FR19980011065 Applic. Date: 1998-09-04

Inventor: AUGUSTE FREDERIC [FR]; ARNAUD PASCAL [FR]; FOURON JEAN-YVES [FR]


Patent No.: US6338855B1  Issued: 15/Jan/2002

Title: Cleansing articles for skin and/or hair which also deposit skin care actives

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/296334   Filing Date: 22/Apr/1999

Abstract:

The present invention relates to a substantially dry, disposable, personal cleansing article useful for both cleansing the skin or hair and delivering skin care actives onto the skin or hair. These articles are used by the consumer by (i) wetting the dry article with water and (ii) generating lather by subjecting the wetted article to mechanical forces, e.g., rubbing. The article comprises a water insoluble substrate, a lathering surfactant, and a skin care active component. Preferably, the articles of the present invention further comprise a deposition aid and/or a conditioning component.

Priority: US1998-065991 Applic. Date: 1998-04-24; US1997-974033 Applic. Date: 1997-11-19; US1996-738145 Applic. Date: 1996-10-25; US1996-738668 Applic. Date: 1996-10-25; US19980083015P Applic. Date: 1998-04-24

Inventor: ALBACARYS LOURDES DESSUS [US]; MCATEE DAVID MICHAEL [US]; DECKNER GEORGE ENDEL [US]


Patent No.: US6338858B1  Issued: 15/Jan/2002

Title: Topical aqueous gel composition

Applicant/Assignee: L'OREAL

Application No.: 09/039399   Filing Date: 16/Mar/1998

Abstract:

An aqueous solid topical composition comprising a matrix, i.e., an aqueous solid matrix, having the appearance of a gel and possessing the following rheological profile:an initial viscosity at rest V0 sufficient to form a solid composition, preferably ranging from 50,000 to 1,000,000 Pa.s, said viscosity V0 being stable up to a shear strain C1,a viscosity V2 after shear at a strain C2 for which the ratio V0/V2 is greater than or equal to 1000:1,the difference C2-C1 being less than or equal to 1000 Pa,and which may be useful as a make-up, styling, body hygiene or care composition.

Priority: FR19970003119 Applic. Date: 1997-03-14

Inventor: DUPUIS CHRISTINE [FR]; SAMAIN HENRI [FR]; ROULIER VERONIQUE [FR]; FERRARI VERONIQUE [FR]


Patent No.: US6338962B1  Issued: 15/Jan/2002

Title: Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell

Applicant/Assignee: THE GENERAL HOSPITAL CORPORATION

Application No.: 09/579744   Filing Date: 26/May/2000

Abstract:

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.

Priority: US1997-927318 Applic. Date: 1997-09-11; US19960026294P Applic. Date: 1996-09-11

Inventor: BOYCE FREDERICK M [US]


Patent No.: US6340495B1  Issued: 22/Jan/2002

Title: Device including a chromophoric composition to be applied to the skin, a method of fabricating such a device, and uses therefor

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 09/207267   Filing Date: 09/Dec/1998

Abstract:

The invention relates to device making it possible to apply a chromophoric composition to the skin, said device including a chromophoric composition containing at least one chromophoric agent. The chromophoric composition is in the form of a layer of constant thickness bonded to one face of backing, at least prior to being applied to the skin, the chromophoric agent or agents being distributed uniformly in said composition, and the type of the composition being chosen such that light energy from laser radiation is transformed locally into heat and/or the chemical structure(s) of the chromophoric agent(s) is/are modified locally.

Priority: FR19970015953 Applic. Date: 1997-12-16

Inventor: SUMIAN CHRYSLAIN [FR]; PITRE FRANCK [FR]; MORDON SERGE [FR]


Patent No.: US6342208B1  Issued: 29/Jan/2002

Title: Oil-in-water emulsion containing C10-C24 fatty acid derivatives for treating skin of mammals

Applicant/Assignee: PLUM KERNI PRODUKTION A/S

Application No.: 09/230777   Filing Date: 08/Mar/1999

Abstract:

An oil-in-water emulsion for application on a skin surface is disclosed. The emulsion comprises an oily phase and an aqueous phase. The oily phase comprises a first lipid of vegetable or animal origin. The emulsion is stabilized by containing at least one surfactant/emulsifier. The surfactant/emulsifier is substantially removed from a skin surface onto which the emulsion has been applied and from the emulsion by flushing with a liquid, thereby leaving at least a part of the oily phase on the skin. When the emulsion is diluted with tap water, which has a degree of hardness of about 18 degrees in a volume of 100 parts of water to one part of the emulsion at ambient temperature, it is separated into at least two distinct phases after standing for 24 hours at ambient temperature. The emulsion has a pH value of at least about 6 and at least about 50% w/w of the total concentration of the surfactant/emulsifier which is a fatty acid derivative. The fatty acid derivative has a fatty acid component which is a saturated or unsaturated C10-C24 hydrocarbon carboxylic acid or mixtures thereof. The emulsion can be used in a method for cleansing or conditioning a skin surface, for treating human skin, for treating mammals against parasites belonging to the phylum Arthropoda and for protecting human skin against the sun.

Priority: DK19960000828 Applic. Date: 1996-08-02; DK19960001465 Applic. Date: 1996-12-20; WO1997DK00324 Applic. Date: 1997-08-01

Inventor: HYLDGAARD JORGEN [DK]; LARSEN JIMMI [DK]; JENSEN ANETTE SEVERIN [DK]


Patent No.: US6342469B1  Issued: 29/Jan/2002

Title: Make-up removing and/or cleansing cosmetic composition in the form of a water-in-oil emulsion

Applicant/Assignee: L'OREAL

Application No.: 09/489841   Filing Date: 24/Jan/2000

Abstract:

The invention relates to a make-up removing and/or cleansing cosmetic composition in the form of a water-in-oil emulsion and comprising (1) at least one silicone emulsifier, (2) at least one branched-chain hydrocarbonaceous oil and (3) at least one make-up removing oil chosen from esters of a fatty acid comprising at least 12 carbon atoms. The composition is fluid and may be used, for example, to remove make-up from the skin without any nuisance or irritation and with excellent effectiveness.

Priority: FR19990001445 Applic. Date: 1999-02-08

Inventor: LORANT RALUCA [FR]


Patent No.: US6342486B1  Issued: 29/Jan/2002

Title: Polymer glucan ether derivatives, their manufacturing as well as their use

Applicant/Assignee: MIBELLE AG COSMETICS

Application No.: 08/896926   Filing Date: 18/Jul/1997

Abstract:

A method for treatment of skin includes topical application of a composition containing a therapeutically effective amount of a 1,3-beta-glucan ether derivative. Such application effectively provides treatment and/or prophylaxis of various skin-related problems, such as neurodermatitis and psoriasis, and reduces the evidence of aging by minimizing wrinkles. In an advantageous embodiment, the glucan ether derivative is present in the composition in a range of concentration of about 0.002% to about 8% by weight. In another embodiment the glucan ether derivative is advantageously carboxymethyl glucan sodium salt.

Priority: DE19961029117 Applic. Date: 1996-07-19

Inventor: ZUELLI FRED [CH]; SUTER FRANZ [CH]


Patent No.: US6344185B1  Issued: 05/Feb/2002

Title: Self-tanning composition

Applicant/Assignee: SHISEIDO CO., LTD

Application No.: 09/491854   Filing Date: 26/Jan/2000

Abstract:

By combining dihydroxyacetone as the active skin coloring agent in combination found with a blend of dispersion polymers and polyester polymers, an easily employed, self-tanning formulation is realized which produces a long lasting, naturally appearing coloring of the skin without any orange pigmentation being produced. In addition, tan colored skin produced by the present invention maintains the desired color for extended periods of time. In the present invention, the dispersion polymers stabilize the dihydroxyacetone as well as provide a thickening agent for the composition. In addition, the present invention also incorporates an oil soluble polyester polymer in combination with the other ingredients which achieves a formulation which provides a slow release of the active ingredient.

Priority: US19990117698P Applic. Date: 1999-01-29

Inventor: ARGUS LISA [US]; KAMBE TETSUYA [US]


Patent No.: US6344186B1  Issued: 05/Feb/2002

Title: Oil-in-water emulsions containing a 1,3,5-triazine derivative and a copolyol silicone and cosmetic applications

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/355739   Filing Date: 22/Dec/1999

Abstract:

The present application relates to novel oil-in-water emulsions comprising i) at least one specific 1,3,5-triazine derivative and ii) at least one polyalkyl-polyethersiloxane carrying polyoxyalkylene groups grafted onto the main silicone chain

with the proviso that the said emulsions do not comprise cetylstearyltrimethylammonium chloride.Another subject-matter of the present invention is the use of such emulsions in the manufacture of cosmetic or dermatological compositions intended for the photoprotection of the skin and/or hair and/or other keratinous substances against ultraviolet radiation, in particular solar radiation.

Priority: FR19970015310 Applic. Date: 1997-12-04; WO1998FR02425 Applic. Date: 1998-11-13

Inventor: HANSENNE ISABELLE [FR]; JOSSO MARTIN [FR]; NODARI LAURENT [FR]


Patent No.: US6344461B1  Issued: 05/Feb/2002

Title: Treating skin wrinkles/fine lines with calcium channel inhibitors

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/572234   Filing Date: 17/May/2000

Abstract:

A regime or regimen for loosening/slackening and/or relaxing cutaneous and/or subcutaneous human skin tissue, advantageously for cosmetically/therapeutically treating skin wrinkles and fine lines, comprises administering to a candidate subject in need of such treatment, a thus-effective amount of at least one inhibitor of at least one calcium channel.

Priority: FR19990006290 Applic. Date: 1999-05-18

Inventor: BRETON LIONEL [FR]; NONOTTE ISABELLE [FR]


Patent No.: US6346255B1  Issued: 12/Feb/2002

Title: Plant polar lipid permeation enhancer in a cosmetic pad for improving skin appearance

Applicant/Assignee: LAVIPHARM LABORATORIES INC

Application No.: 09/232422   Filing Date: 15/Jan/1999

Abstract:

Devices for the improvement of skin appearance are provided, said devices including a pad with a backing layer, a release layer, and a vehicle located therebetween, the vehicle containing a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. The invention also relates to a method of improving skin appearance using the devices of the invention.

Priority: US19980071379P Applic. Date: 1998-01-15; US19980075890P Applic. Date: 1998-02-25; US19980087917P Applic. Date: 1998-06-04; US19980095089P Applic. Date: 1998-08-03

Inventor: FOTINOS SPIROS [GR]


Patent No.: US6346256B1  Issued: 12/Feb/2002

Title: Stable O/W/O emulsion and its use as a cosmetic and/or dermatological composition

Applicant/Assignee: L'OREAL

Application No.: 09/384430   Filing Date: 27/Aug/1999

Abstract:

An oil/water/oil triple emulsion is stabilized with at least one partially or completely crosslinked organopolysiloxane elastomer having at least one polyoxyethylenated and/or polyoxypropylenated chain. The stable triple emulsion can be used as a composition for topical application, in particular as a cosmetic or dermatological composition, and especially as a vehicle for active principles. The emulsion is particularly useful for cleansing and/or treating and/or protecting the skin and/or mucous membranes and/or keratinous fibers.

Priority: FR19980011263 Applic. Date: 1998-09-09

Inventor: SIMON PASCAL [FR]


Patent No.: US6346278B1  Issued: 12/Feb/2002

Title: Lipid extract having anti-inflammatory activity

Applicant/Assignee: PHARMALINK INTERNATIONAL LIMITED

Application No.: 09/610484   Filing Date: 05/Jul/2000

Abstract:

Anti-inflammatory, and particularly anti-arthritic, treatment of a human or animal patient comprises administration to the patient of an effective amount of a lipid extract of Perna canaliculus or Mytilus edulis.

Priority: AU1995PN05311 Applic. Date: 1995-09-11

Inventor: MACRIDES THEODORE [AU]; KALAFATIS NICOLETTE [AU]


Patent No.: US6348199B1  Issued: 19/Feb/2002

Title: Skin treatment cream

Applicant/Assignee:

Application No.: 08/177576   Filing Date: 05/Jan/1994

Abstract:

A clear, transparent highly stable skin moisturizing and lubricating composition is provided comprising the product obtained by combining polyglyceryl methacrylate with a pharmaceutically acceptable silicone, in the presence of a suitable emulsifier under application of pressure in the range of about 13,000 to about 50,000 psi. The compositions are adapted for use as cosmetics and/or carriers for active drugs and serve in this form for treatment of skin irritations, burns, skin infections and the like. A method of preparing the compositions of the invention is disclosed. The invention also contemplates methods for lubricating and moisture replenishment of the skin, treating burns, skin infections and the like by topically applying the disclosed skin treatment compositions of the invention.

Priority: US1993-036374 Applic. Date: 1993-03-24

Inventor: VERNICE JOSEPH [US]; GLOBUS ALFRED R [US]


Patent No.: US6348203B1  Issued: 19/Feb/2002

Title: Nitroimidazole gel composition

Applicant/Assignee: BIOGLAND IRELAND (R&D) LIMITED

Application No.: 09/331367   Filing Date: 11/Feb/2000

Abstract:

A viscous hydrogel composition, for use in a topical treatment of a skin condition involving dry or inflammed skin, comprising an antimicrobially active nitroimidazole drug, a water miscible alkylene glycol, a bydroxyalkyl cellulose gelling agent and water, buffered to have a physiologically acceptable pH and a method of making the same.

Priority: GB19960026513 Applic. Date: 1996-12-20; WO1997GB03512 Applic. Date: 1997-12-19

Inventor: GOODMAN MICHAEL [GB]; LINDAHL AKE [SE]


Patent No.: US6348204B1  Issued: 19/Feb/2002

Title: Cosmetic or dermatological composition containing at least one extract of mulberry, at least one extract of skullcap and at least one salicylic acid derivative

Applicant/Assignee: L'OREAL

Application No.: 09/415219   Filing Date: 12/Oct/1999

Abstract:

A cosmetic or dermatological composition, comprising:in combination, at least one extract of mulberry or an active substance isolated from the extract, at least one extract of skullcap or an active substance isolated from the extract and at least one salicylic acid derivative or salt thereof.

Priority: FR19980012747 Applic. Date: 1998-10-12

Inventor: TOUZAN PHILIPPE [FR]


Patent No.: US6348218B1  Issued: 19/Feb/2002

Title: Self dosing skin preparation

Applicant/Assignee: INVENT RESOURCES, INC

Application No.: 09/411085   Filing Date: 04/Oct/1999

Abstract:

A self dosing skin composition and method releases sun blocking agent or other active ingredient onto the skin of a user as a function of exposure to at least one environmental condition over time. The environmental condition is preferably exposure to sun light, in particular, harmful UV radiation. The composition includes a medium adapted to be spread onto the skin of a user and a reservoir defining at least one wall for containing at least one sun blocking or other agent. The reservoir is dispersed in the medium and the wall is designed and/or selected to deteriorate over time with exposure to the environmental condition or conditions, for releasing the agent into the medium and onto the skin. At least one agent is provided in the reservoir. The reservoir is preferably in the form of a multiplicity of microcapsules dispersed in the medium, each microcapsule having a wall containing the at least one agent, each wall deteriorating over time with exposure to the at least one environmental condition for opening the microcapsule to release the agent.

Priority: WO2001US29925 Applic. Date: 2001-09-25

Inventor: HED AHARON ZE EV [US]; PAVELLE RICHARD [US]; AISENBERG SOL [US]; FREEDMAN GEORGE [US]


Patent No.: US6348503B1  Issued: 19/Feb/2002

Title: Method and topical treatment composition for herpesvirus hominis

Applicant/Assignee: SQUIRES MERYL J

Application No.: 08/600217   Filing Date: 12/Feb/1996

Abstract:

Improved topical treatment of active phase lesions resulting from recurrent viral infection by herpes simplex virus which includes the use of two primary agents, namely, an aqueous solution of benzalkonium halide, preferably benzalkonium chloride, and a dry form of the herb Echinacea purpurea, preferably in powder form. Active phase herpes lesions are wetted with the benzalkonium chloride solution and dusted with the powder form of Echinacea purpurea to create a coating on the wetted lesion surface. The coating is maintained on the lesion throughout treatment, and unexpected rapid resolution of the lesions results.

Priority:

Inventor: SQUIRES MERYL [US]


Patent No.: US6352685B2  Issued: 05/Mar/2002

Title: External preparation for skin

Applicant/Assignee: KOSvā CORPORATION SHIRATORI PHARMACEUTICAL CO., LTD

Application No.: 09/740859   Filing Date: 22/Dec/2000

Abstract:

The object of the invention is to provide a new external preparation for skin having high melanine formation inhibition and also anti-aging effect, and desired drug effect can be obtained without degradation in a pharmaceutical preparation.The external preparation for skin includes the extract of Pueraria mirifica in conbination with an active ingredient selected from the group consisting of a whitening agent, an anti-oxidant, an anti-inflammation agent, an ultraviolet-ray shielding ingredient, a cell activation agent and humectant.

Priority: JP19990367587 Applic. Date: 1999-12-24; JP20000029348 Applic. Date: 2000-02-07

Inventor: HOSHINO TAKU [JP]; SAKATA OSAMU [JP]; MORIYAMA MASAHIRO [JP]; HIGUCHI YOSHIHIRO [JP]


Patent No.: US6352699B1  Issued: 05/Mar/2002

Title: Cosmetic or dermatological composition forming, on a keratin substrate, a film in cross-linked hybrid material

Applicant/Assignee: L'OREAL

Application No.: 09/381735   Filing Date: 03/Dec/1999

Abstract:

The invention concerns a cosmetic or dermatological composition designed for for forming a film on a keratin substrate, in cross-linked hybrid material. Said composition is of the sol/gel type and is obtained by mixing: (a) at least an organometallic compound

(b) at least a functionalised organic polymer or said polymer precursor, or at least a functionalised silicone polymer or said polymer precursor, the precursor being different from (a)

(c) a sufficient amount of water for hydrolysing the organometallic compound: and (d) optionally at least an alcohol

said film being non-reversible.

Priority: FR19970004157 Applic. Date: 1997-04-04; WO1998FR00682 Applic. Date: 1998-04-03

Inventor: MONDET JEAN [FR]; QUINN FRANCIS XAVIER [FR]; SANCHEZ CLEMENT [FR]


Patent No.: US6355232B1  Issued: 12/Mar/2002

Title: Agent for protecting skin and hair moisture

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 09/331418   Filing Date: 21/Jun/1999

Abstract:

A skin protective agent which comprises as a sole ceramide component the erythro (2S, 3R) type of a ceramide and has a remarkably excellent water-barrier ability.

Priority: JP19960341107 Applic. Date: 1996-12-20; WO1997US23266 Applic. Date: 1997-12-16

Inventor: KANEKO TERUHISA [JP]; TANAKA TOMOYA [JP]; NAGASE MASAAKI [JP]


Patent No.: US6355657B1  Issued: 12/Mar/2002

Title: System for percutaneous delivery of opioid analgesics

Applicant/Assignee: ATRIX LABORATORIES, INC

Application No.: 09/475094   Filing Date: 30/Dec/1999

Abstract:

Compositions and methods for the topical delivery of loperamide hydrochloride are disclosed. Novel solvent mixtures have been found to be beneficial in enhancing the penetration of loperamide hydrochloride through the skin.

Priority: US19980114224P Applic. Date: 1998-12-30

Inventor: OSBORNE DAVID W [US]


Patent No.: US6358498B1  Issued: 19/Mar/2002

Title: Personal care product in the form of a free-standing stick

Applicant/Assignee: COTY B.V

Application No.: 09/642489   Filing Date: 18/Aug/2000

Abstract:

A new personal care product in the form of a free-standing stick comprises an inner core with cosmetic ingredients and an solid outer shell adhering to the inner core, in which the outer shell is wax-free and contains at least solid proteins, liquid polyols or solutions of polyols, solid polyols, emollients and additional cosmetic auxiliary materials and active ingredients. The outer surface does not transfer pigment through brief contact with the skin and is also not sticky.

Priority: DE19991040221 Applic. Date: 1999-08-19

Inventor: YU WEI H [US]; KULKARNI RUPALI A [US]; MACCHIO RALPH [US]; BARONE SALVATORE J [US]; CORRIGAN ANTONIETTA [US]


Patent No.: US6358500B1  Issued: 19/Mar/2002

Title: Stable W/O/W emulsion and its use as cosmetic and/or dermatological composition

Applicant/Assignee: L'OREAL

Application No.: 09/314953   Filing Date: 20/May/1999

Abstract:

A water/oil/water triple emulsion comprising an aqueous external phase and a W/O primary emulsion comprising an oily phase and an aqueous internal phase, which comprises at least one partially or completely crosslinked organopolysiloxane elastomer comprising a polyoxyethylenated and/or polyoxypropylenated chain. The emulsion may be used, for example for cleansing and/or treating and/or protecting the skin and/or mucous membranes and/or keratinous fibers.

Priority: FR19980006412 Applic. Date: 1998-05-20

Inventor: SIMON PASCAL [FR]


Patent No.: US6358518B2  Issued: 19/Mar/2002

Title: Composition in the form of an O/W emulsion with a high wax content, and uses thereof in cosmetics and dermatology

Applicant/Assignee: L'OREAL

Application No.: 09/764402   Filing Date: 19/Jan/2001

Abstract:

A creamy composition in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that it contains at least one anionic emulsifier which is liquid at room temperature, and at least 5% by weight of one or more waxes relative to the total weight of the composition, and in that the oily phase is in the form of a soft paste at room temperature.

The anionic emulsifier is preferably a surfactant containing a phosphate group, such as octyldecyl phosphate.The present invention also relates to the uses of the said composition in cosmetics and dermatology, in particular for caring for, treating and/or making up the skin and/or mucous membranes, and more particularly for treating wrinkles and/or fine lines of the skin and/or for treating dry skin.The invention also relates to a process for preparing this composition, characterized in that at least one step of the process is carried out using a mixer-extruder.

Priority: FR19980015293 Applic. Date: 1998-12-03; US1999-451918 Applic. Date: 1999-12-01

Inventor: ROULIER VERONIQUE [FR]; SIMON PASCAL [FR]


Patent No.: US6361763B1  Issued: 26/Mar/2002

Title: Photochromic tanning and sunscreen lotion

Applicant/Assignee:

Application No.: 09/535179   Filing Date: 27/Mar/2000

Abstract:

A photochromic tanning and sunscreen lotion having photochromic compounds that change color upon exposure to sunlight or other sources of ultraviolet radiation (UV) to create the appearance of a tanned skin, and which also form a shield against UV radiation to thereby provide an effective sunscreen.

Priority:

Inventor: CARROLL GEORGE H [US]


Patent No.: US6361765B1  Issued: 26/Mar/2002

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/586589   Filing Date: 02/Jun/2000

Abstract:

Antiperspirant compositions herein comprise an antiperspirant active, together with a carrier and a structurant for the carrier which comprises an organic wax having a melting point of from 40 to 90 DEG C. of which at least 60% of the weight of the wax is provided by at least one aliphatic ester satisfying the formula:in which n is from 9 to 39 and m is from 0 to 35 to form a solid or a soft solid. The compositions can be anhydrous, in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions.The formulations structured by the selected waxes provide lower visible deposits on topical application compared with conventional wax-structured formulations and the waxes are effective at structuring/thickening at a proportion below that in conventional wax-structured formulations.It is especially desirable to employ emulsion formulations comprising a continuous phase which comprises from 10 to 35% volatile silicone oil, and from 5 to 15% non-volatile hydrophobic oil, from 40 to 75% of ta disperse aqueous phase which contains from 1 to 35% of an antiperspirant or deodorant active, from 7 to 25% of a wax structurant, from 0.1 to 10% of an emulsifier, and preferably contains up to 5% insoluble particulate materials, % s being by weight based on the composition.

Priority: GB19990012924 Applic. Date: 1999-06-03; GB20000011084 Applic. Date: 2000-05-08

Inventor: EMSLIE BRUCE STEVEN [GB]; STOIMENOF LAURA DIMITROVA [GB]; TURNER GRAHAM ANDREW [GB]


Patent No.: US6361766B1  Issued: 26/Mar/2002

Title: Antiperspirant formulations

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE, USA DIVISION OF CONOPCO, INC

Application No.: 09/920778   Filing Date: 02/Aug/2001

Abstract:

Anhydrous antiperspirant formulations in which a particulate antiperspirant active is suspended in a carrier fluid can result in significant visible deposits when applied to skin or when transferred onto clothing.Anhydrous antiperspirant suspension sticks which exhibit very low visible deposits are obtainable by employing a carrier fluid in which at least 45% and preferably at least 60% of its weight comprises an oxygen-containing emollient oil having a refractive index of at least 1.465, in conjunction with structurant comprises a wax or a non-polymeric fiber-forming gellant, excluding certain gellants or gellant combinations. Preferred emollient oils include alkyl benzoates and alkylphenylsiloxanes. The waxes can even comprise fatty alcohols.

Priority: GB20000019232 Applic. Date: 2000-08-04

Inventor: FRANKLIN KEVIN RONALD [GB]; TURNER GRAHAM ANDREW [GB]


Patent No.: US6361782B1  Issued: 26/Mar/2002

Title: Cosmetic composition in anhydrous form comprising a dispersion of a surface-stabilized polymer particles

Applicant/Assignee: L'OREAL

Application No.: 09/551629   Filing Date: 17/Apr/2000

Abstract:

The present invention relates to a composition, in particular a cosmetic or dermatological composition, for caring for and/or making up the skin, that includes:a liquid fatty phase including polymer particles that are dispersed and surface-stabilized therein, anda dyestuff, whereinthe liquid fatty phase includes a volatile liquid phase and a non-volatile liquid phase, the non-volatile phase having a solubility parameter deltah<=5 (J/cm3) 1/2 and wherein a volatile phase/non-volatile phase weight ratio ranges from 2 to 25. This composition makes it possible to obtain on the skin a flexible, comfortable, non-greasy film which can camouflage marks, dyschromia and couperose on the skin. The invention also relates to a process for camouflaging marks and other dyschromia on the skin.

Priority: FR19990004815 Applic. Date: 1999-04-16

Inventor: CHEVALIER VERONIQUE [FR]; HUREL VALERIE [FR]


Patent No.: US6361785B1  Issued: 26/Mar/2002

Title: Method and compositions for treatment of fungal nail disease

Applicant/Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

Application No.: 09/655561   Filing Date: 06/Sep/2000

Abstract:

Compositions for the treatment of fungal nail disease (onychomycosis), including camphor, menthol, eucalyptus and thymol are described. The ingredients are natural and very effective in treating the nail fungus.

Priority: US2000-498405 Applic. Date: 2000-02-04; US19990118974P Applic. Date: 1999-02-08

Inventor: NAIR MURALEEDHARAN G [US]; RAMSEWAK RUSSEL S [US]; KING SHARON K [US]; STOMMEL MANFRED [US]; SELANDERS LOUISE C [US]


Patent No.: US6365135B1  Issued: 02/Apr/2002

Title: Use of amino phenol amide derivatives as depigmentation agents

Applicant/Assignee: L'OREAL

Application No.: 09/355968   Filing Date: 10/Nov/1999

Abstract:

The invention relates to the use of aminophenol amide derivatives in a composition as an agent for depigmenting and/or bleaching human skin, body hairs and/or head hair. The invention also relates to a process for depigmenting and/or bleaching the skin, body hairs and/or head hair, which consists in applying a composition comprising aminophenol amide derivatives to human skin, body hairs and/or head hair.

Priority: FR19970016171 Applic. Date: 1997-12-19; WO1998FR02562 Applic. Date: 1998-11-27

Inventor: PHILIPPE MICHEL [FR]; TULOUP REMY [FR]; DUVAL CHRISTINE [FR]


Patent No.: US6365200B1  Issued: 02/Apr/2002

Title: Topical skin sensitizer

Applicant/Assignee:

Application No.: 09/619913   Filing Date: 19/Jul/2000

Abstract:

A topically applied aphrodisiac dispersed in a manually applied vehicle which substantially increases tissue sensation. The active ingredients are benzalkonium chloride, aloe and vitamin E in a water soluble gel which includes sorbitol, glycerin, and hydroxethylcellulose.

Priority:

Inventor: BIRNHOLZ JASON C [US]; KENT FRANCES B [US]


Patent No.: US6365656B1  Issued: 02/Apr/2002

Title: Liquid dispersion polymer compositions, their preparation and their use

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 09/543287   Filing Date: 05/Apr/2000

Abstract:

Liquid dispersion polymer compositions which comprise microparticles of a hydrophilic, water soluble or swellable polymer, preferably an acrylic-based polymer, dispersed in a di- or triglyceride oil such as soybean oil and an oil-in-water surfactant, are useful to prepare microparticulate thickening systems to thicken aqueous or aqueous/organic compositions, particularly for use in personal care and pharmaceutical formulations. The preparation and the use of these liquid dispersion polymer compositions is described.

Priority: US19990128114P Applic. Date: 1999-04-07

Inventor: GREEN MICHAEL [GB]; RIDLEY ELEANOR BERNICE [GB]; GAVIN DWAYNE ERICK [US]


Patent No.: US6368584B1  Issued: 09/Apr/2002

Title: Detergent cosmetic compositions comprising an anionic hydroxyalkyl ether surfactant and a silicone, and their uses

Applicant/Assignee: L'OREAL S.A

Application No.: 09/504376   Filing Date: 15/Feb/2000

Abstract:

The invention relates to novel detergent cosmetic compositions comprising, in a cosmetically acceptable medium, at least one anionic surfactant chosen from 2-hydroxyalkyl ether carboxylic acid and salts thereof and at least one silicone chosen from: (i) volatile or non-volatile, linear, branched or cyclic and crosslinked or non-crosslinked polyalkylsiloxanes, polyarylsiloxanes or polyalkylarylsiloxanes

(ii) polysiloxanes comprising, in their general structure, one or more organofunctional groups chosen from: a) substituted or unsubstituted aminated groups

b) (per)fluorinated groups

c) thiol groups

d) carboxylate groups

e) hydroxylated groups

f) alkoxylated groups

g) acyloxyalkyl groups

h) amphoteric groups

i) bisulphite groups

j) hydroxyacylamino groups

k) carboxylic acid groups

l) sulphonic groups

m) sulphate or thiosulphate groups

(iii) linear polysiloxane(A)-polyoxyalkylene(B) block copolymers of (A-B)n type with n>3

(iv) grafted silicone polymers composed of a main chain not comprising silicone

and (v) grafted silicone polymers composed of a polysiloxane main chain.

Priority:

Inventor: GARNIER NATHALIE [US]; CAUWET-MARTIN DANIELE [FR]; RESTLE SERGE [FR]


Patent No.: US6368618B1  Issued: 09/Apr/2002

Title: Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs

Applicant/Assignee: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC

Application No.: 09/346187   Filing Date: 01/Jul/1999

Abstract:

A novel topical formulation for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) is characterized by enhanced transdermal absorption and efficacy. A two phase liquid composition has aqueous and oil phases, the oil phase having a relatively high concentration of the NSAID to enhance transdermal absorption and efficacy when incorporated into the topical anti-inflammatory formulation. The two phase liquid composition preferably contains, in addition to an NSAID, at least one melting point depressing agent. A preferred topical anti-inflammatory composition includes S(+)-ibuprofen, thymol, and ethyl alcohol or isopropyl alcohol.

Priority:

Inventor: JUN H WON [US]; KANG LISHENG [US]


Patent No.: US6369047B2  Issued: 09/Apr/2002

Title: ANDROGENIC STEROID COMPOUNDS AND A METHOD OF MAKING AND USING THE SAME

Applicant/Assignee: RESEARCH TRIANGLE INSTITUTE

Application No.: 09/328436   Filing Date: 09/Jun/1999

Abstract:

An androgenic steroid compound of the formula:wherein:X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.

Priority: US1997-979369 Applic. Date: 1997-11-26

Inventor: COOK C EDGAR [US]; KEPLER JOHN A [US]; LEE YUE-WEI [US]; WANI MANSUKH C [US]


Patent No.: US6372234B1  Issued: 16/Apr/2002

Title: Products for topical applications comprising oil bodies

Applicant/Assignee: SEMBIOSYS GENETICS INC

Application No.: 09/577147   Filing Date: 24/May/2000

Abstract:

The present invention provide novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Priority: US1999-448600 Applic. Date: 1999-11-24; US1998-084777 Applic. Date: 1998-05-27; US19980075863P Applic. Date: 1998-02-25; US19980075864P Applic. Date: 1998-02-25; US19970047779P Applic. Date: 1997-05-27; US19970047753P Applic. Date: 1997-05-27

Inventor: DECKERS HARM M [CA]; ROOIJEN GIJS VAN [CA]; BOOTHE JOSEPH [CA]; GOLL JANIS [CA]; MOLONEY MAURICE M [CA]


Patent No.: US6372717B1  Issued: 16/Apr/2002

Title: Synthetic peptides and their use in cosmetic or dermopharmaceutical compositions

Applicant/Assignee: SEDERMA S.A

Application No.: 09/242687   Filing Date: 23/Feb/1999

Abstract:

The invention concerns the use of peptides of general formula R1-L-Tyr-L-Arg-R2 in which R1=H or a R3-C=0 with R3=a C1 to C20 alkyl chain, linear or branched, saturated or unsaturate, hydroxylated or not, or with R3=an aryl, aryl-alkyl or alkyloxy or aryloxy or arylalkyloxy group, and in which R2=OH or a O-R4 group with R4=a C1 to C20 alkyl chain, or R2=a NH2, NHX or NXX group with X=a C1 to C4 alkyl chain. The peptides have a soothing effect on the skin, including by topical application, and attenuates the effects of benign skin sores (after shave irritation, sunstroke, frostbite, chaps, depilation). They are used in acceptable cosmetic excipients and in effective in vivo concentrations.

Priority: WO1996FR01322 Applic. Date: 1996-08-23

Inventor: GREFF DANIEL [FR]


Patent No.: US6375127B1  Issued: 23/Apr/2002

Title: Active control surface modal system for aircraft buffet and gust load alleviation and flutter suppression

Applicant/Assignee:

Application No.: 09/612058   Filing Date: 07/Jul/2000

Abstract:

The present invention relates to an Active Control Surface Modal (ACSM) device that generates unsteady aerodynamic damping to alleviate aeroelastic structural instability, vibration and dynamic loads. An active control surface modal deformation is created by means of a pair of antagonistically activated actuators. Since the masses of upper and lower surface skins are lighter, the modal deformations can be activated at high frequencies that can encompass wide band spectrum of buffet, gust and flutter problem areas. An independent dosed loop active control system is used to activate the ACSM modes. Measured acceleration sensors are used as the feedback signals to compute the coefficients of the control law that is designed to suppress the dynamic environments such as buffet, gust and flutter. Then a computerized control system algorithm outputs a series of voltage signals that pass through power amplifiers to activate the actuators. Then the ACSM device generates unsteady aerodynamic damping in out-of-phase with the external (buffet/gust) or self excited air loads (flutter) to reduce or eliminate the undesirable dynamic effects on the aircraft. Some buffet analyses of a vertical tail, typical of a fighter aircraft, show 80 per cent reduction in peak stress, which amounts to an eight fold fatigue life extension of the vertical tail.

Priority:

Inventor: APPA KARI [US]


Patent No.: US6375936B1  Issued: 23/Apr/2002

Title: Photoprotective cosmetic composition containing an anionic surfactant, compounds for screening out ultraviolet radiation and a cationic or zwitterionic amphiphilic compound, and use thereof

Applicant/Assignee: L'OREAL

Application No.: 09/486240   Filing Date: 24/Feb/2000

Abstract:

The invention relates to a cosmetic composition, in particular for photoprotecting the skin and/or the hair, in the form of a dispersion comprising two immiscible phases stabilized with at least one anionic surfactant chosen from the salts of fatty acids and of monovalent or polyvalent metals, of ammonium or of organic bases, a compound for screening out ultraviolet radiation, which can be adsorbed at the interface of the said immiscible phases, derived from benzylidenecamphor and comprising at least one partially or totally neutralized sulphonic acid function, a metal oxide nanopigment coated with hydrophobic hydrocarbon-based coating agents and a cationic or zwitterionic amphiphilic compound which leads, with the anionic surfactant, to the formation of a compound capable of lowering the water/liquid paraffin interface tension at 40 DEG C. by more than 14 mN.m-1 for an anionic surfactant concentration of 0.1 mmol/100 g, by more than 26 mN.m-1 for an anionic surfactant concentration of 0.5 mmol/100 g and by more than 33 mN.m-1 for an anionic surfactant concentration of 1 mmol/100 g.

Priority: FR19980008828 Applic. Date: 1998-07-09; WO1999FR01608 Applic. Date: 1999-07-05

Inventor: ALLARD DELPHINE [FR]; CANDAU DIDIER [FR]; NICOLAS-MORGANTINI LUC [FR]


Patent No.: US6375938B1  Issued: 23/Apr/2002

Title: Antiperspirant and deodorant compositions containing a low molecular weight polyethylene gellant

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 09/842560   Filing Date: 26/Apr/2001

Abstract:

The present invention embraces an anhydrous topical antiperspirant or deodorant composition comprising an antiperspirant or deodorant active, a dermatologically acceptable volatile silicone liquid carrier vehicle and a polyethylene homopolymer dissolved in the vehicle to serve as a thickening or solidifying agent, wherein the polyethylene homopolymer has a molecular weight of about 200 to about 800 daltons, preferably about 300 to about 600 daltons, most preferably about 400 to about 500 daltons. The composition should be substantially free of any other organic or natural waxes. The present invention also embraces a method of inhibiting or reducing perspiration or a method of inhibiting or reducing malodor by topically applying an effective amount of such an antiperspirant composition or deodorant composition to the skin.

Priority:

Inventor: CLOTHIER JR JAMES G [US]; CARLSON SR JEFFREY R [US]; COLWELL DENNIS J [US]


Patent No.: US6375960B1  Issued: 23/Apr/2002

Title: Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the cosmetics, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/474074   Filing Date: 29/Dec/1999

Abstract:

The present invention provides a nanoemulsion, that includes:an oily phase dispersed in an aqueous phase

andat least one surfactant that is solid at a temperature of less than or equal to 45 DEG C. and which is selected from the group including ethoxylated fatty ethers and ethoxylated fatty esters, and mixtures thereof

whereinthe oily phase includes oil globules having a number-average size of less than 100 nm

wherein the oily phase includes at least one oil having a molecular weight of greater than 400

andwherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic, opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

Priority: FR19980016570 Applic. Date: 1998-12-29

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6376437B2  Issued: 23/Apr/2002

Title: Skin cleansing composition for removing ink

Applicant/Assignee: GOJO INDUSTRIES, INC

Application No.: 09/895671   Filing Date: 02/Jul/2001

Abstract:

A skin cleansing composition suitable for removing ink and other stains from the hands and arms of a user includes an effective amount of a low molecular weight alcohol having from one to twelve carbon atoms and an effective amount of a peroxide releasing agent, e.g., a perborate salt, preferably sodium perborate, such that together, the alcohol and perborate salt provide a synergistic reaction that effectively removes ink from the skin of the user. Other additives such as fillers, abrasives, and detergents may be employed to provide further cleansing action.

Priority: US1999-428250 Applic. Date: 1999-10-27

Inventor: VISCOVITZ JOHN [US]; DOLAN MICHAEL J [US]


Patent No.: US6376679B2  Issued: 23/Apr/2002

Title: Photoprotective/cosmetic compositions comprising novel benz-x-azole-substituted silane/siloxane sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/740063   Filing Date: 20/Dec/2000

Abstract:

Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2):in which A is a radical having the structural formula (I):

Priority: FR19970015309 Applic. Date: 1997-12-04; US1998-205607 Applic. Date: 1998-12-04

Inventor: LEDUC MADELEINE [FR]; RICHARD HERVE [FR]; LAGRANGE ALAIN [FR]


Patent No.: US6379655B1  Issued: 30/Apr/2002

Title: Photoprotective/cosmetic compositions comprising aminoamidine sunscreens

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/722473   Filing Date: 28/Nov/2000

Abstract:

Topically applicable sunscreen/cosmetic compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise an effective UV-photoprotecting amount of at least one characteristically novel aminoamidine compound, advantageously having the structural formula (I):formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990014999 Applic. Date: 1999-11-29

Inventor: BRETON PHILIPPE [FR]


Patent No.: US6379692B1  Issued: 30/Apr/2002

Title: Pharmaceutical composition comprising a suspension for the active ingredient

Applicant/Assignee: CHAUVIN PHARMACEUTICALS LIMITED

Application No.: 09/145900   Filing Date: 02/Sep/1998

Abstract:

A pharmaceutical formulation may be prepared by a method comprising providing the active ingredient in solution in a pharmacologically-acceptable base and mixing the resulting solution with a pharmacologically-acceptable acid in an amount such that the formulation attains a pH in the range of from about 3.5 to about 8.5 to thereby precipitate out the active ingredients, a viscosity-enhancing agent having been incorporated in the formulation prior to or during the mixing with acid. The formulation is suitable for administration of a pharmacologically active ingredient which is sparingly soluble in water at a pH acceptable for administration, for example to the eye of the patient.

Priority: GB19970018568 Applic. Date: 1997-09-03

Inventor: RAO LEBURU SESHAGIRI [GB]


Patent No.: US6379718B2  Issued: 30/Apr/2002

Title: Use of plant extracts for treatment of acne and furuncle

Applicant/Assignee:

Application No.: 09/745455   Filing Date: 21/Dec/2000

Abstract:

Novel herbal extracts provide potent efficacy in the treatment of acne and furuncle. The formulated extracts of Momordica charantia L. are from either the whole plant or parts of the plant. The extracts have been formulated into aqueous solution, pads, and/or lotion. These formulations have been provided to treat acne and furuncle 2 to 3 times a day. It has demonstrated the ability to manage various grades of acne, from mild, moderate to severe, which include comedos, papules, pustules and nodules. Significant improvement is visible within five days. There are no observed either long-term or short-term side reactions.

Priority: US1999-350342 Applic. Date: 1999-07-14

Inventor: REN KAIJUN [US]


Patent No.: US6383476B1  Issued: 07/May/2002

Title: Anhydrous antiperspirant and deodorant compositions containing a solid, water-soluble, skin active agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/799147   Filing Date: 05/Mar/2001

Abstract:

Disclosed are anhydrous antiperspirant and deodorant compositions that comprise from about 0.1% to about 30% by weight of an antiperspirant or deodorant active

from about 0.1% to about 20% by weight of a water-soluble, skin active solid (e.g., solid, water-soluble vitamins or other nutrients) other than the antiperspirant or deodorant active

from about 0.1% to about 40% by weight of a suspending agent

and from about 10% to about 99% by weight of an anhydrous carrier liquid, wherein the composition is substantially free of nonvolatile organic liquids having a C log P value greater than about 7.0. The anhydrous compositions allow the water-soluble skin active solids to release into the sweat or other moisture on the skin more rapidly or to a greater extent, thus enhancing any skin active effect resulting from such active materials contacting the skin, especially the underarm area of skin.

Priority:

Inventor: SCAVONE TIMOTHY ALAN [US]; SCHLAGHECK BENJAMIN SCOTT [US]


Patent No.: US6384025B2  Issued: 07/May/2002

Title: Retinyl carbonate derivatives, preparation process and uses

Applicant/Assignee: L'OREAL

Application No.: 09/942565   Filing Date: 31/Aug/2001

Abstract:

The present invention relates to novel retinol derivatives having the formula (I):and to processes for preparing them. The invention also relates to the use of these compounds in or for the preparation of compositions intended for treating conditions of the skin or scalp, for example in preventing or combating acne and/or chronological or actinic ageing of the skin.

Priority: FR19990006872 Applic. Date: 1999-06-01; US2000-580833 Applic. Date: 2000-05-30

Inventor: TULOUP REMY [FR]; DALKO MARIA [FR]; RUBINSTENN GILLES [FR]


Patent No.: US6384296B1  Issued: 07/May/2002

Title: Disposable article having a responsive system including an electrical actuator

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/342766   Filing Date: 29/Jun/1999

Abstract:

Disposable articles such as diapers, incontinent briefs, diaper holders and/or inserts, training pants, feminine hygiene garments, tampons and the like having a responsive system including an electrical actuator. The responsive system may respond continuously or discontinuously. A continuous responsive system of the present invention further includes a feedback control loop. A discontinuous responsive system of the present invention may include either a feedback control loop or an open loop.

Priority: US19980090993P Applic. Date: 1998-06-29

Inventor: ROE DONALD C [US]; ALLEN PATRICK J [US]; EHRNSPERGER BRUNO J [DE]; SCHMIDT MATTIAS [DE]; KRUCHININ MIKHAIL L [RU]; LITVIN SIMON S [US]; KHOMJAKOV OLEG N [RU]; RONN KARL P [US]


Patent No.: US6387358B2  Issued: 14/May/2002

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 09/759123   Filing Date: 12/Jan/2001

Abstract:

Soft solid antiperspirant formulations in which a particulate antiperspirant active material is suspended in a continuous phase containing a water-immiscible liquid which is structured by specified proportions of an organic polymeric thickener and a second structurant selected from fibre-forming structurants and waxes (often other than fatty alcohols) or a mixture of both.Such soft solid formulations avoid or minimise problems inherent in production of many published formulations such as sensitivity to small changes in concentration of the structurant.

Priority: GB20000000875 Applic. Date: 2000-01-14; GB20000016942 Applic. Date: 2000-07-10

Inventor: CHUAH BENG SIM [GB]; CLARE SARAH JANE [GB]; FRANKLIN KEVIN RONALD [GB]; HOUGH GORDON CHARLES [GB]; TURNER GRAHAM ANDREW [GB]


Patent No.: US6387383B1  Issued: 14/May/2002

Title: Topical low-viscosity gel composition

Applicant/Assignee: DOW PHARMACEUTICAL SCIENCES

Application No.: 09/632508   Filing Date: 03/Aug/2000

Abstract:

A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) optionally a water miscible solvent, (d) optionally a preservative, (e) optionally an oil phase component and suitable surfactant, and (f) water. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea. The low viscosity composition has an advantage of being administered more accurately when combined with a container that administers the composition as drops.

Priority:

Inventor: DOW GORDON J [US]; LATHROP ROBERT W [US]; DOW DEBRA A [US]


Patent No.: US6387858B1  Issued: 14/May/2002

Title: Safe transport gel for treating medical instruments

Applicant/Assignee: STERIS INC

Application No.: 09/540950   Filing Date: 31/Mar/2000

Abstract:

A method for treating medical instruments after a surgical procedure, which leaves blood or other body fluid on the instrument, includes applying a gel composition that inhibits the fluid from drying on the instruments. The gel composition is preferably a low viscosity gel exhibiting both sufficient flow and coating characteristics. The viscosity is preferably from about 700 to about 4,000 centipoise (cps), preferably around 3,000 cps. Applying a gel to post-surgical medical instruments contains and keeps protein containing fluids moist for extended periods of time and facilitates subsequent transportation, cleaning, and sterilization of such instruments.

Priority:

Inventor: SHAH SAYED S [US]; KELLER SHAHIN [US]; BERNANDO MILDRED R [US]


Patent No.: US6387947B1  Issued: 14/May/2002

Title: Antimicrobial cosmetic compositions

Applicant/Assignee: E-L MANAGEMENT CORP

Application No.: 09/269141   Filing Date: 23/Aug/1999

Abstract:

The present invention relates to cosmetic or pharmaceutical formulations for topical application which comprises an anti-inflammatory effective amount of 3-furan carboxylic acid. The formulation also optionally comprises an anti-irritant effective amount of frulic acid and an antimicrobial effective 2-furan carboxylic acid.

Priority: US1997-896194 Applic. Date: 1997-07-17; WO1998US14666 Applic. Date: 1998-07-15

Inventor: SCHNITTGER STEVEN F [US]; DECLERCQ LIEVE [BE]


Patent No.: US6391290B1  Issued: 21/May/2002

Title: Skin care compositions

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 09/813614   Filing Date: 21/Mar/2001

Abstract:

Disclosed are skin care compositions that are emulsion formulations comprising an aqueous phase, an oil phase, at least one emulsifier, and an epichlorohydrin cross-linked glyceryl starch.

Priority:

Inventor: FOWLER KEVIN [US]


Patent No.: US6391323B1  Issued: 21/May/2002

Title: Composition for the treatment of burns, sunburns, abrasions, ulcers and cutaneous irritation

Applicant/Assignee:

Application No.: 09/555008   Filing Date: 23/May/2000

Abstract:

A composition having analgesic, antiseptic and skin healing promoting activity, suitable for the treatment of burns, sunburns, scalds, irritation, sores and abrasions which includes, as active ingredients, chlorophyll, cod liver oil, and camphor, preferably together with a natural antiseptic agent chosen from niaouli oil, thyme oil, and mixtures thereof, in a pharmaceutically acceptable vehicle for topical application.

Priority: IT1997RM00731 Applic. Date: 1997-11-26; WO1998IT00339 Applic. Date: 1998-11-24

Inventor: CARNEVALI ANDREA [IT]


Patent No.: US6391848B1  Issued: 21/May/2002

Title: Soybean protein nutraceuticals

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 09/303814   Filing Date: 30/Apr/1999

Abstract:

The invention provides methods and comprisitions for delivering effective amounts of lunasin as a nutraceutical. The general formulation comprises a composition comprising an active unit dosage of a lunasin polypeptide and a pharmaceutically acceptable excipient. The formulations may be delivered or administered by oral ingestion, by topically contacting skin using well known techniques for dermal delivery, by introducing into a retained physiological fluids. The invention also provides methods for making the subject formulations by purifying lunasin polypeptides to the requisite purity, and combining said lunasin polypeptide with a pharmaceuitcally acceptible excipient in an orally active unit dosage. The lunasin source material may be soybeans, a recombinant lunasin polypeptide expression system, a synthetically produced lunasin, or extract or fraction thereof.

Priority:

Inventor: DE LUMEN BENITO O [US]; GALVEZ ALFREDO F [US]


Patent No.: US6391860B1  Issued: 21/May/2002

Title: Method for preparation and use of paste formed by controlled reaction of sucralfate with hydrochloric acid

Applicant/Assignee:

Application No.: 09/391922   Filing Date: 09/Sep/1999

Abstract:

Disclosed is a sucralfate composition which is employed in the treatment of lesions. The composition is formed by the reaction between sucralfate and hydrochloric acid prior to dosing under controlled conditions which limit the reaction to an incomplete stage. The present invention contemplates various methods of achieving this incomplete reaction. In one example, a volume of sucralfate is mixed with a volume of hydrochloric acid. In additional examples, the sucralfate is first wetted in water before being mixed with the hydrochloric acid. Still yet another example involves mixing a volume of sucralfate powder with a powdered excipient before being mixed with the hydrochloric acid.

Priority:

Inventor: MCGRATH PATRICK D [US]


Patent No.: US6391863B1  Issued: 21/May/2002

Title: Use of carbohydrates for promoting skin desquamation

Applicant/Assignee: L'OREAL

Application No.: 09/043914   Filing Date: 16/Jun/1998

Abstract:

The use of carbohydrate derivatives in or for making a topical composition for promoting skin exfoliation is disclosed. The use of said composition of controlling intrinsic and extrinsic skin ageing, as well as a non-therapeutic skin treatment method for skin exfoliation, are also disclosed.

Priority: FR19950011661 Applic. Date: 1995-10-04; WO1996FR01522 Applic. Date: 1996-09-30

Inventor: PHILIPPE MICHEL [FR]; EBENHAN-NAPPE CATHERINE [FR]


Patent No.: US6395281B1  Issued: 28/May/2002

Title: Cosmetic skin conditioning compositions containing red yeast rice extract

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, A DIVISION OF CONOPCO, INC

Application No.: 09/737072   Filing Date: 14/Dec/2000

Abstract:

Cosmetic methods and compositions for conditioning human skin by topical application to the skin of cosmetic compositions containing red yeast rice extract. Cosmetic compositions containing red yeast rice extract in combination with ascorbyl palmitate, or sodium ascorbyl phosphate, or retinol, or retinyl ester are also disclosed.

Priority: US19990170669P Applic. Date: 1999-12-14

Inventor: JANUARIO THOMAS EUGENE [US]; SANTHANAM UMA [US]; PILLAI SREEKUMAR [US]; MAHAJAN MANISHA NARAYAN [US]; BAJOR JOHN STEVEN [US]


Patent No.: US6395285B1  Issued: 28/May/2002

Title: Anhydrous composition containing a volatile fluoro compound, and uses thereof, in particular cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/684620   Filing Date: 10/Oct/2000

Abstract:

An anhydrous cosmetic composition comprising, in a fatty phase, at least one elastomeric, solid polyorganosiloxane which is at least partially cross-linked and at least one volatile fluoro oil with a density of greater than 1.

Priority: FR19990013448 Applic. Date: 1999-10-27

Inventor: LORANT RALUCA [FR]


Patent No.: US6395297B1  Issued: 28/May/2002

Title: Transdermal preparation contacting a loratidine metabolite with antihistaminic activity

Applicant/Assignee: HEXAL AG

Application No.: 09/572771   Filing Date: 17/May/2000

Abstract:

A transdermal patch contains an active loratidine metabolite contained with polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.

Priority: DE19944442999 Applic. Date: 1994-12-02

Inventor: KLOKKERS KARIN [DE]; FISCHER WILFRIED [DE]; BRACHER DANIEL [DE]


Patent No.: US6395765B1  Issued: 28/May/2002

Title: Antiparasitic composition for the treatment and protection of pets

Applicant/Assignee: MERIAL

Application No.: 08/719942   Filing Date: 25/Sep/1996

Abstract:

Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution:a) an insecticidal active substance of formula (I),b) a crystallization inhibitor,c) an organic solvent having a dielectric constant of between 10 and 35, preferably of between 20 and 30,d) an organic co-solvent having a boiling point below 100 DEG C., preferably below 80 DEG C., and a dielectric constant of between 10 and 40, preferably of between 20 and 30.

Priority: FR19950011685 Applic. Date: 1995-09-29; FR19960011278 Applic. Date: 1996-09-11

Inventor: ETCHEGARAY JEAN PIERRE [FR]


Patent No.: US6399048B1  Issued: 04/Jun/2002

Title: Self-tanning cosmetic compositions

Applicant/Assignee: L'OREAL

Application No.: 09/053822   Filing Date: 02/Apr/1998

Abstract:

Novel cosmetic compositions for artificially tanning the skin, comprising at least one self-tanning agent, in particular DHA, and at least one dendrimer.

Priority: FR19970004159 Applic. Date: 1997-04-04

Inventor: ALLARD DELPHINE [FR]; FORESTIER SERGE [FR]


Patent No.: US6399051B2  Issued: 04/Jun/2002

Title: Method and agents for permanently styling hair, with a base consisting of N,N-disubstituted mercaptoacetamides

Applicant/Assignee: WELLA AKTIENGESELLSCHAFT

Application No.: 09/269901   Filing Date: 08/Jun/1999

Abstract:

The present invention relates to a composition and method for permanently shaping hair, in which an N,N-disubstituted mercaptoacetamide of the formula I:or a salt thereof, wherein R1 and R2 are each independently selected from the group consisting of straight-chain alkyl groups having 1 to 6 carbon atoms, branched-chain alkyl groups having 1 to 6 carbon atoms, monohydroxyalkyl groups having 1 to 6 carbon atoms, polyhydroxyalkyl groups having 1 to 6 carbon atoms and carboxyalkyl groups having 1 to 6 carbon atoms, is employed as keratin reducing agent. A process for making these mercaptoacetamides is also described as well as a novel mercaptoacetamide, N-ethyl-2'-hydroxyethyl-mercaptoacetamide. The mercaptoacetamides provide gentle and uniform shaping of hair in a pH range of 4.5 to 9.5 and do not cause allergic or sensitizing reactions.

Priority: DE19971033952 Applic. Date: 1997-08-06; WO1998EP04678 Applic. Date: 1998-07-25

Inventor: DANNECKER BEATE [DE]; LANG GUENTHER [DE]; HANEFELD WOLFGANG [DE]; WALTHER HEIKO [DE]


Patent No.: US6399105B1  Issued: 04/Jun/2002

Title: Sea cucumber carotenoid lipid fraction products and methods of use

Applicant/Assignee:

Application No.: 09/622220   Filing Date: 15/Aug/2000

Abstract:

Methods and compositions of matter are described for treatment of inflammatory autoimmune and other diseases by administration of lipid fractions of sea cucumber tissue. Compositions of matter useful for inclusion in aquatic and human diets are also disclosed.

Priority: WO1999US01179 Applic. Date: 1999-01-20

Inventor: COLLIN PETER DONALD [US]


Patent No.: US6403061B1  Issued: 11/Jun/2002

Title: UV-photoprotecting W/O emulsions comprising micronized insoluble screening agents & nonscreening oxyalkylenated silicones

Applicant/Assignee: SOCIETE L'OREAL

Application No.: 09/693888   Filing Date: 23/Oct/2000

Abstract:

Topically applicable, water-resistant cosmetic/dermatological water-in-oil (W/O) emulsions well suited for the UV-photoprotection of human skin and/or hair comprise (a) at least one aqueous phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 mum, and (d) at least one oxyalkylenated non-UV-screening organomodified silicone.

Priority: FR19990013219 Applic. Date: 1999-10-22

Inventor: CANDAU DIDIER [FR]; FORESTIER SERGE [FR]


Patent No.: US6403071B1  Issued: 11/Jun/2002

Title: Anhydrous antiperspirant and deodorant compositions containing solid d-pantothenate salts

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/799367   Filing Date: 05/Mar/2001

Abstract:

Disclosed are anhydrous antiperspirant and deodorant compositions comprising from about 0.1% to about 30% by weight of an underarm active (antiperspirant and/or deodorant active)

from about 0.01% to about 10% by weight of a solid, water-soluble, d-pantothenate salt such as calcium pantothenate

from about 0.1% to about 40% by weight of a suspending agent

and from about 10% to about 99% by weight of an anhydrous carrier liquid. Also disclosed are methods of controlling perspiration wetness and/or odor through the topical application to the underarm, especially shaven underarms, of an underarm active and a solid pantothenate salt. The anhydrous compositions are mild to the skin and can help sooth or heal skin irritated or damaged underarm skin, especially when such irritation and damage is the result of occasional or routine shaving of the underarm.

Priority:

Inventor: SCAVONE TIMOTHY ALAN [US]; SCHLAGHECK BENJAMIN SCOTT [US]


Patent No.: US6403072B1  Issued: 11/Jun/2002

Title: Anhydrous antiperspirant and deodorant compositions containing a solid, water-soluble, skin active agent and glycerin

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/845018   Filing Date: 27/Apr/2001

Abstract:

Disclosed are anhydrous antiperspirant and deodorant compositions that comprise from about 0.1% to about 30% by weight of an antiperspirant or deodorant active

from about 0.1% to about 20% by weight of a water-soluble, skin active solid (e.g., solid, water-soluble vitamins or other nutrients) other than the antiperspirant or deodorant active

from about 0.1% to about 40% by weight of a suspending agent

from about 0.1% to about 2.0% by weight of glycerin

and from about 10% to about 99% by weight of an anhydrous carrier liquid other than glycerin. The anhydrous compositions have lower visible residue on the applied areas of the skin even though they also contain relatively high residue solids in the form of water-soluble skin active solids other than and in addition to the antiperspirant and deodorant active. The compositions also provide for a dry, silky feeling during or after application.

Priority: US2001-799147 Applic. Date: 2001-03-05

Inventor: SCAVONE TIMOTHY ALAN [US]; SCHLAGHECK BENJAMIN SCOTT [US]; CASSIERE KELLY LYNN [US]


Patent No.: US6403125B1  Issued: 11/Jun/2002

Title: Utilization of an extract of a plant of the Cecropia genus

Applicant/Assignee: COGNIS FRANCE (SOCIETE ANONYME)

Application No.: 09/868722   Filing Date: 21/Jun/2001

Abstract:

The utilization of at least one extract of a plant belonging to the cecropia genus as an active agent. The extract is used alone or in conjunction with at least one other active agent for preparing a cosmetic or dermopharmaceutical product or a cosmetic or dermopharmaceutical composition for external local application on the skin, the mucous membranes and/or the epithelial or body appendage formations.

Priority: WO1999EP10031 Applic. Date: 1999-12-16; FR19980016289 Applic. Date: 1998-12-21

Inventor: PAULY GILLES [FR]; MORETTI CHRISTIAN [FR]


Patent No.: US6403565B1  Issued: 11/Jun/2002

Title: Antimutagenic compositions for treatment and prevention of photodamage to skin

Applicant/Assignee: PRO-NEURON, INC

Application No.: 09/387523   Filing Date: 01/Sep/1999

Abstract:

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.

Priority: US1997-963831 Applic. Date: 1997-11-04

Inventor: VON BORSTEL REID W [US]; ROMANTSEV FEDOR [US]


Patent No.: US6403653B1  Issued: 11/Jun/2002

Title: Active topical skin protectants using reactive nanoparticles

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY NANOSCALE MATERIALS, INC

Application No.: 09/871747   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: HOBSON STEPHEN T [US]; BRAUE JR ERNEST H [US]; LEHNERT ERICH K [US]; KLABUNDE KENNETH J [US]; KOPER OLGA P [US]; DECKER SHAWN [US]


Patent No.: US6403704B1  Issued: 11/Jun/2002

Title: Composition comprising particles of a hydrophilic polyorganosiloxane suspended in an aqueous phase

Applicant/Assignee: L'ORvāAL S.A

Application No.: 09/500085   Filing Date: 08/Feb/2000

Abstract:

The invention relates to a composition for cosmetic or topical application comprising particles of an at least partially crosslinked elastomeric solid polyorganosiloxane suspended in an aqueous phase, wherein the composition is substantially water-resistant. This composition is more especially a make-up composition or a care composition for the lips or a foundation composition for making up the human face or body. This composition is soft and feels fresh when applied, it spreads easily, it is non-sticky and it does not dry out the skin or the lips. It is entirely suitable for greasy skin, on account of its high matte-effect power.

Priority: FR19990001447 Applic. Date: 1999-02-08

Inventor: BARA ISABELLE [FR]


Patent No.: US6406708B1  Issued: 18/Jun/2002

Title: Therapeutic compositions

Applicant/Assignee: INTERHEALTH AB

Application No.: 09/700215   Filing Date: 13/Nov/2000

Abstract:

The invention relates to a composition comprising, from 2 to 8% squalane, from 1.5 to 8% cyclodextrin, and from 1.5 to 8% of a pharmaceutically and/or cosmetically acceptable acid selected from aliphatic mono-, di- and alpha-hydroxy carboxylic acids having from 2 to 10 carbon atoms, and the balance selected from other pharmaceutically and/or cosmetically acceptable compatible anti-acne active substances as well as pharmaceutically and/or cosmetically acceptable paste, ointment or cream bases and additives. The composition has therapeutic and cosmetic effect and can be used as a cosmetic as well as for the preparation of a drug for prophylactic and curative treatment of acne. A method for the preparation of the composition as well as a method for treatment of acne is also included in the invention.

Priority: SE19980001647 Applic. Date: 1998-05-12; WO1999SE00819 Applic. Date: 1999-05-12

Inventor: KAERNERUD LARS [SE]; OELMESKOG STELLAN [SE]


Patent No.: US6406709B1  Issued: 18/Jun/2002

Title: Method for inhibiting nematocyst discharge

Applicant/Assignee: NIDARIA TECHNOLOGY LTD

Application No.: 09/543903   Filing Date: 06/Apr/2000

Abstract:

Compositions for inhibiting nematocyst or polar capsule discharge are provided in the form of an effective amount of antihistamine, an effective amount of antihistamine and an effective amount of at least one cation, or an effective amount of at least one cation. The compositions can be in the form of ointments or can be added to the environment surrounding the nematocysts or polar capsules. Methods of inhibiting nematocyst or polar capsule discharge using the compositions of the invention are also provided.

Priority: US1997-947077 Applic. Date: 1997-10-08; US1997-865322 Applic. Date: 1997-05-29

Inventor: LOTAN AMIT [IL]


Patent No.: US6407056B1  Issued: 18/Jun/2002

Title: Methods for altering hair growth and hair pigmentation by apoptosis in the follicular papillae and compositions therefor

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 08/882322   Filing Date: 25/Jun/1997

Abstract:

The present invention utilizes serine proteases and their ability to induce programmed cell death and apoptosis in the follicular papillae to affect changes in mammalian hair growth and hair pigmentation. Also described are compositions which have an agent with a portion of similar structure to a portion of the trypsin molecule, allowing said agent to induce programmed cell death and apoptosis in the same manner as trypsin.

Priority: US19960021629P Applic. Date: 1996-07-12

Inventor: SEIBERG MIRI [US]; SHAPIRO STANLEY S [US]; CAUWENBERGH GERARD F M J [US]; WISNIEWSKI STEPHEN J [US]


Patent No.: US6409998B1  Issued: 25/Jun/2002

Title: UV-photoprotecting emulsions comprising micronized insoluble screening agents and associative polymers

Applicant/Assignee: SOCIETE L'OREAL

Application No.: 09/693889   Filing Date: 23/Oct/2000

Abstract:

Topically applicable, water-resistant cosmetic/dermatological emulsions well suited for the UV-photoprotection of human skin and/or hair contain an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 mum, and further containing at least one associative polymer which is characteristically other than a C8-C16 alkyl polyglucoside.

Priority: FR19990013220 Applic. Date: 1999-10-22

Inventor: CANDAU DIDIER [FR]; FORESTIER SERGE [FR]; PISSON ANNE-MARIE [FR]


Patent No.: US6409999B2  Issued: 25/Jun/2002

Title: Synergistically UV-photoprotecting benzotriazole-substituted silicon/cinnamic acid compositions

Applicant/Assignee: SOCIETE L'OREAL

Application No.: 09/796636   Filing Date: 02/Mar/2001

Abstract:

Topically applicable cosmetic/dermatological compositions suited for improvedly UV-photoprotecting human skin and/or hair against the deleterious effects of ultraviolet irradiation, advantageously oil-in-water emulsions, contain SPF-synergistically enhancing amounts of (a) at least one UV-screening benzotriazole-substituted silicon compound and (b) at least one UV-screening cinnamic acid derivative, formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR19990008568 Applic. Date: 1999-07-02; WO2000FR01696 Applic. Date: 2000-06-20

Inventor: AGOSTINI ISABELLE [FR]; ARNAUD PASCAL [FR]; GUILLARD SYLVIE [FR]


Patent No.: US6410001B1  Issued: 25/Jun/2002

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE, USA, A DIVISION OF CONOPCO, INC

Application No.: 09/620858   Filing Date: 21/Jul/2000

Abstract:

Compositions for application to human skin have a continuous phase which contains water-immiscible oil structured by incorporation of a compound of formulain which Y and Y1 are each independently -CH2 or >CO Q and Q1 are each independently a hydrocarbyl group of at least 6 carbon atoms and m is from 2 to 4.The composition may be an antiperspirant containing suspended particulate antiperspirant active or containing a dispersed phase in which antiperspirant active is dissolved in water or water-immiscible solvent.

Priority: EP19990305840 Applic. Date: 1999-07-23

Inventor: FRANKLIN KEVIN RONALD [GB]; STOTT IAN PETER [GB]; BHAT RAHILA [GB]


Patent No.: US6410003B1  Issued: 25/Jun/2002

Title: Antiperspirant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 09/920777   Filing Date: 02/Aug/2001

Abstract:

Antiperspirant formulations containing an antiperspirant active and a continuous phase comprising a water-immiscible liquid carrier, such as, amongst other materials, cyclomethicones, that is structured using an amido-containing compound of the general formulain which R and R1 each independently denote a branched or unbranched moiety containing 5 to 27 carbon atoms, m and n are each independently, zero or 1, Y is a cyclohexane ring bearing the amido-containing substituent groupsin 1,2 or 1,3 positions.

Priority: GB20000019231 Applic. Date: 2000-08-04

Inventor: BHATIA SHAMEEM [GB]; FRANKLIN KEVIN RONALD [GB]; STOIMENOF LARA DIMITROVA [GB]; WHITE MICHAEL STEPHEN [GB]


Patent No.: US6410017B1  Issued: 25/Jun/2002

Title: Personal care compositions containing active proteins tethered to a water insoluble substrate

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/401093   Filing Date: 22/Sep/1999

Abstract:

The present invention relates to personal care compositions comprising a water insoluble substrate, a plurality of active proteins, and a binding means, comprising a polymeric tether, permanently attaching each of the enzymes to the substrate wherein the personal care composition comprises from about 0.01 mug/cm2 to about 1000 mug/cm2 of the enzyme on the substrate.

Priority: US19980101361P Applic. Date: 1998-09-22

Inventor: WEISGERBER DAVID JOHN [US]; ALLCOCK ANDREW CAMPBELL [US]


Patent No.: US6410038B1  Issued: 25/Jun/2002

Title: Water-in-oil-in-polar solvent emulsions

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/593529   Filing Date: 14/Jun/2000

Abstract:

Water-in-oil-in-non-aqueous polar solvent W/O/PS type multiple emulsion contains a water phase W dispersed in an oil O as the first continuous phase of a primary emulsions W/O by an emulsifier. Primary emulsion W/O is dispersed in a second continuous non-aqueous polar solvent phase PS to form multiple emulsion W/O/PS. The emulsifier is a silicone elastomer containing polyether groups which is a network of polymeric molecules crosslinked with an alpha,omega-unsaturated hydrocarbon.

Priority:

Inventor: LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]


Patent No.: US6410048B1  Issued: 25/Jun/2002

Title: Prolamin-plant polar lipid combination, preparation method and applications

Applicant/Assignee: LABORATORIES LAVIPHARM S.A

Application No.: 09/554486   Filing Date: 18/Jul/2000

Abstract:

The invention provides a prolamine-plant polar lipid association, wherein the prolamine and plant polar lipid components are present in such proportions so that stable films can be obtained with this association, which is preferably in the form of a hydro-alcoholic gel comprising: 20-40% w/w of prolamines, preferably gliadin

0.1-5% w/w of ceramides, preferably wheat ceramides

hydro-ethanolic solution (35 to 80 DEG ) ad 100%.This association may be used for preparing films, patches, aerosols for use in the delivery of active substances such as therapeutic and cosmetic agents.

Priority: FR19970014242 Applic. Date: 1997-11-13; WO1998FR02400 Applic. Date: 1998-11-10

Inventor: FOTINOS SPIROS [GR]


Patent No.: US6410603B1  Issued: 25/Jun/2002

Title: Active topical skin protectants using combinations of reactive nanoparticles and polyoxometalates or metal salts

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY NANOSCALE MATERIALS, INC EMORY UNIVERSITY

Application No.: 09/871744   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and a active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: HOBSON STEPHEN T [US]; BRAUE ERNEST H [US]; LEHNERT ERICH K [US]; KLABUNDE KENNETH J [US]; DECKER SHAWN [US]; HILL CRAIG L [US]; RHULE JEFFREY [US]; BORING ERIC [US]; KOPER OLGA [US]


Patent No.: US6410604B1  Issued: 25/Jun/2002

Title: Active topical skin protectants containing OPAA enzymes and clecs

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/871749   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: BRAUE JR ERNEST H [US]; HOBSON STEPHEN T [US]; GOVARDHAN CHANDRIKE [US]; KHALAF NAZAR [US]


Patent No.: US6413526B1  Issued: 02/Jul/2002

Title: Cosmetic and/or dermatological composition comprising a dispersion of a polymer system, and use of this system as a tensioning agent

Applicant/Assignee: L'OREAL

Application No.: 09/348167   Filing Date: 07/Jul/1999

Abstract:

The present invention relates to an anti-wrinkle composition containing a dispersion of a polymer system comprising at least one polymer of natural origin, and to the use of this polymer system as a tensioning agent in a cosmetic or dermatological composition.The polymer used must characteristically have a molecular weight of greater than 670,000 daltons and the polymer system obtained must be capable of forming a steam-permeable film, it must have a Young's modulus ranging from 108 to 9x109 N/m2 and it must produce, at a concentration of 7%, a greater than 1.5% retraction of isolated stratum corneum at 30 DEG C. and at a relative humidity of 40%.The composition obtained is used in particular for the immediate treatment of wrinkles and fine lines on the skin.

Priority: FR19970000033 Applic. Date: 1997-01-03

Inventor: BAZIN ROLAND [FR]; BERNARDET LAURENT [FR]; CANDAU DIDIER [FR]; MALLE GERARD [FR]; GARSON JEAN-CLAUDE [FR]


Patent No.: US6413527B1  Issued: 02/Jul/2002

Title: Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/478408   Filing Date: 06/Jan/2000

Abstract:

A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Priority: FR19990000408 Applic. Date: 1999-01-14

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6413529B1  Issued: 02/Jul/2002

Title: Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/536314   Filing Date: 27/Mar/2000

Abstract:

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

Priority: US19990128952P Applic. Date: 1999-04-13

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; CEN RAYMOND WEI [US]; BAKKEN SCHUETTE THERESA ANNE [US]


Patent No.: US6413942B1  Issued: 02/Jul/2002

Title: Methods of delivering a physiologically active polypeptide to a mammal

Applicant/Assignee: VICAL, INC WISCONSIN ALUMNI RESEARCH FOUNDATION

Application No.: 09/449923   Filing Date: 02/Dec/1999

Abstract:

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.

Priority: US1995-481932 Applic. Date: 1995-06-07; US1994-215405 Applic. Date: 1994-03-18; US1992-846827 Applic. Date: 1992-03-06; US1990-496991 Applic. Date: 1990-03-21; US1990-467881 Applic. Date: 1990-01-19; US1989-326305 Applic. Date: 1989-03-21

Inventor: FELGNER PHILIP L [US]; WOLFF JON ASHER [US]; RHODES GARY H [US]; MALONE ROBERT WALLACE [US]; CARSON DENNIS A [US]


Patent No.: US6414037B1  Issued: 02/Jul/2002

Title: Pharmaceutical formulations of resveratrol and methods of use thereof

Applicant/Assignee: PHARMASCIENCE

Application No.: 09/430337   Filing Date: 29/Oct/1999

Abstract:

A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.

Priority: US1998-005114 Applic. Date: 1998-01-09

Inventor: PEZZUTO JOHN M [US]; MOON RICHARD C [US]; JANG MEI-SHIANG [US]; OUALI AOMAR [CA]; LIN SHENGZHAO [CA]; BARILLAS KARLA SLOWING [ES]


Patent No.: US6414039B1  Issued: 02/Jul/2002

Title: Active topical skin protectants containing polyoxometalates and/or coinage metal complexes

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/871746   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: BRAUE JR ERNEST H [US]; HOBSON STEPHEN T [US]; HILL CRAIG L [US]; BORING ERIC [US]; RHULE JEFF [US]


Patent No.: US6416748B1  Issued: 09/Jul/2002

Title: Emulsifier-free UV-photoprotecting emulsions comprising micronized insoluble screening agents

Applicant/Assignee: SOCIETE L'OREAL

Application No.: 09/693894   Filing Date: 23/Oct/2000

Abstract:

Topically applicable, water-resistant but emulsifier-free cosmetic/dermatological emulsions well suited for the UV-photoprotection of human skin and/or hair contain (a) at least one aqueous phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 mum and (d) optionally, at least one crosslinked polymer of at least one ethylenically unsaturated monomer.

Priority: FR19990013221 Applic. Date: 1999-10-22

Inventor: CANDAU DIDIER [FR]; PISSON ANNE-MARIE [FR]


Patent No.: US6416751B1  Issued: 09/Jul/2002

Title: Cosmetic and/or dermatological powder, process for its preparation and its uses

Applicant/Assignee: L'OREAL

Application No.: 09/243495   Filing Date: 03/Feb/1999

Abstract:

A cosmetic and/or dermatological powder comprising from 5 to 70% of modified starch and from 30 to 95% of oily phase comprising at least one oil. The present invention also relates to a process for manufacturing a cosmetic and/or dermatological powder comprising at least one modified starch and an oily phase, by (1) preparing an oil-in-water dispersion by mixing an oily phase comprising at least one oil in an aqueous phase comprising at least one modified starch, the oily phase/starch weight ratio ranging from 3:7 to 19:1, and (2) dehydrating the dispersion in order to obtain the powder. The powder may be used just as it is and is useful in particular to care for, cleanse, remove make-up from, make up and/or treat the skin, mucous membranes and/or the scalp.

Priority: FR19980001219 Applic. Date: 1998-02-03

Inventor: ROULIER VERONIQUE [FR]; BORDEAUX DOMINIQUE [FR]


Patent No.: US6416756B1  Issued: 09/Jul/2002

Title: Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care

Applicant/Assignee: NOVOZYMES A/S

Application No.: 09/019532   Filing Date: 05/Feb/1998

Abstract:

Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight of the polymeric molecules may be from 1 to 35 kDa and of the enzymes from 15 to 100 kDa. The number and weight of polymeric molecules coupled is balanced with the weight and/or surface area of the enzymes. Enzymes include proteases such as subtilisins, lipases and oxidoreductases such as laccases and superoxide dismutase, and polymeric molecules include polysaccharides such as dextran or pullulan and polyalkylene oxides such as polyethylene glycol. The polymeric molecules may be coupled to the enzymes at the N-terminal amino group and/or lysine residues, and preferably at a position more than 5 AA from the active site of the enzymes. A preferred modified enzyme is a protease having from 5 to 13 coupled polymeric molecules. Skin care products containing the modified enzymes have improved stability and reduced allergenicity as compared to the products containing the unmodified enzymes.

Priority: DK19970000038 Applic. Date: 1997-01-10; DK19970000754 Applic. Date: 1997-06-25; WO1998DK00015 Applic. Date: 1998-01-12; US19970051831P Applic. Date: 1997-07-07

Inventor: OLSEN ARNE AGERLIN [DK]; PRENTO ANNETTE [DK]


Patent No.: US6416767B1  Issued: 09/Jul/2002

Title: Use of peroxidized lipids as agents intended to prevent and/or to treat the irritant effects of an active principle

Applicant/Assignee: LABORATOIRES CARILENE

Application No.: 09/333924   Filing Date: 16/Jun/1999

Abstract:

A composition for topical application to the skin, contains an active principle with irritant character in a cosmetically or pharmaceutically acceptable vehicle, in which the vehicle contains more than 5% by weight of peroxidized vegetable oil having a peroxidation level of between 5 and 600 milliequivalents per kg. The presence of the peroxidized oil reduces the irritant character of the principle, particularly capsaicin and retinoic acid.

Priority: FR19990006079 Applic. Date: 1999-05-12

Inventor: DESJONQUERES STEPHANE [FR]


Patent No.: US6416768B1  Issued: 09/Jul/2002

Title: COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONSISTING OF AN EMULSION OF THE OIL-IN-WATER TYPE FORMED FROM LIPID VESICLES DISPERSED IN AN AQUEOUS PHASE CONTAINING AT LEAST ONE HYDROPHILIC ACIDIC ACTIVE AGENT

Applicant/Assignee: L'OREAL

Application No.: 09/499391   Filing Date: 07/Feb/2000

Abstract:

A composition for topical use, comprising an oil-in-water emulsion formed from lipid vesicles consisting of oily globules, each having a lamellar liquid crystal coating obtained from at least one surfactant, dispersed in an aqueous phase containing at least one hydrophilic acidic active agent but which does not contain a gelling agent.

Priority: FR19990001387 Applic. Date: 1999-02-05

Inventor: RAVAUX DANIELLE [FR]; LAUGIER JEAN-PIERRE [FR]


Patent No.: US6417188B1  Issued: 09/Jul/2002

Title: Arylalkanoylpyridazines

Applicant/Assignee: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG

Application No.: 09/719467   Filing Date: 13/Dec/2000

Abstract:

Arylalkanoylpyridazine derivatives of the formula Iand their physiologically acceptable salts and solvates,in whichR1, R2, Q and B have the meanings indicated in Claim 1, show an inhibition of phosphodiesterase IV and can be employed for the treatment of asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune disorders, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth or tumor metastases, sepsis, memory disorders, atherosclerosis and AIDS.

Priority: DE19981026841 Applic. Date: 1998-06-16; WO1999EP03151 Applic. Date: 1999-05-07

Inventor: JONAS ROCHUS [DE]; WOLF MICHAEL [DE]; KLUXEN FRANZ-WERNER [DE]


Patent No.: US6417226B1  Issued: 09/Jul/2002

Title: SKIN WHITENERS CONTAINING HYDROXYTETRONIC ACID

Applicant/Assignee:

Application No.: 09/735144   Filing Date: 12/Dec/2000

Abstract:

Skin whitening compositions contain alpha-hydroxytetronic acid or a alpha-hydroxy tetronic derivative, and, in some cases, hydroquinone, an alpha-hydroxy acid such as glycolic acid, and a fatty acid ester of ascorbic acid such as ascorbyl palmitate.

Priority:

Inventor: PERRICONE NICHOLAS V [US]


Patent No.: US6417236B1  Issued: 09/Jul/2002

Title: Active topical skin protectants using hybrid organic polysilsesquioxane materials

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Application No.: 09/872097   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: HOBSON STEPHEN T [US]; BRAUE ERNEST H [US]; SHEA KENNETH [US]


Patent No.: US6419642B1  Issued: 16/Jul/2002

Title: Irradiation enhanced permeation and delivery

Applicant/Assignee: TRANSMEDICA INTERNATIONAL, INC

Application No.: 09/589865   Filing Date: 08/Jun/2000

Abstract:

The present invention provides a method of delivering substances for permeation through the skin of a subject, by energizing the stratum corneum in conjunction with various delivery means including gels and patches. Permeability enhancement or reduced electrical impedance of the skin, increases the variety of substances capable of permeation, and increases the permeation rate and the effectiveness of the permeation, including permeation enhanced by iontophoresis. The method allows for the use of improved delivery means that were previously unavailable.

Priority: US1999-443782 Applic. Date: 1999-11-19; US1997-955982 Applic. Date: 1997-10-22; US1997-792335 Applic. Date: 1997-01-31; US1993-126241 Applic. Date: 1993-09-24

Inventor: MARCHITTO KEVIN S [US]; FLOCK STEPHEN T [CA]


Patent No.: US6419912B1  Issued: 16/Jul/2002

Title: Hypoallergenic make-up or care composition comprising a crosslinked organopolysiloxane comprising an oxyalkylene group, and its uses

Applicant/Assignee: L'OREAL

Application No.: 09/538509   Filing Date: 30/Mar/2000

Abstract:

A hypoallergenic composition for making up or caring for keratinous substances which comprises an aqueous phase dispersed in a liquid fatty phase by means of particles of crosslinked elastomeric solid organopolysiloxane comprising at least one oxyalkylene group and in particular an oxyethylene group, the said composition additionally being devoid of cosurfactant. The invention also relates to the use of these particles of elastomeric solid organopolysiloxane in a hypoallergenic and fresh cosmetic composition or for the manufacture of a hypoallergenic and fresh care, treatment or make-up composition, comprising an aqueous phase dispersed in a liquid fatty phase.

Priority: FR19990003969 Applic. Date: 1999-03-30

Inventor: LEZER NATHALIE JAGER [FR]


Patent No.: US6419935B1  Issued: 16/Jul/2002

Title: Cosmetic skin treatment method and cleansing treatment patch

Applicant/Assignee: L'OREAL S.A

Application No.: 09/363171   Filing Date: 29/Jul/1999

Abstract:

A cosmetic skin treatment method includes providing a patch configured to be used in both a cleansing mode and a treatment mode. The patch includes a polymeric matrix and a reinforcing member. The polymeric matrix includes at least one cosmetically active compound and at least one water-absorbent compound. The patch is configured to adhere to dry skin and also to adhere to skin when at least one of the patch and skin are moistened. The method also includes selecting at least one of the cleansing mode and the treatment mode. When the cleansing mode is selected, the method further includes applying the patch to an areas of dry skin so that the polymeric matrix adheres to the skin for a time sufficient to allow at least one impurity in the area of skin to become attached to the polymeric matrix. Thereafter, the patch is removed from the area of the skin while said at least one impurity is attached to the polymeric matrix. When the treatment mode is selected, the method further includes moistening at least one of the patch and an area of the skin. Then, the patch is applied to the area of skin so that the patch adheres to the area of skin. After applying the patch, the cosmetically active compound is allowed to contact the area of skin. A cleansing and treatment patch is also disclosed.

Priority: FR19980009794 Applic. Date: 1998-07-30; FR19980009795 Applic. Date: 1998-07-30; FR19980009880 Applic. Date: 1998-07-31

Inventor: GUERET JEAN-LOUIS H [FR]


Patent No.: US6419946B1  Issued: 16/Jul/2002

Title: Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/459581   Filing Date: 13/Dec/1999

Abstract:

A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm, comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Priority: FR19980015764 Applic. Date: 1998-12-14

Inventor: SONNEVILLE ODILE [FR]; SIMONNET JEAN-THIERRY [FR]; LEGRET SYLVIE [FR]


Patent No.: US6420434B1  Issued: 16/Jul/2002

Title: Active topical skin protectants using polyoxometallates

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/872096   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: BRAUE JR ERNEST H [US]; HOBSON STEPHEN T [US]; WHITE JAMES [US]; BLEY RICHARD [US]; HILL CRAIG L [US]


Patent No.: US6423854B1  Issued: 23/Jul/2002

Title: Aminophenol derivatives and their use in cosmetics

Applicant/Assignee: L'OREAL

Application No.: 09/284490   Filing Date: 21/Jun/1999

Abstract:

Use of at least one aminophenol derivative of formula (I) below:in which:R represents a hydrogen atom or a radical -COR2,wherein R2 represents a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C1 to C30 hydrocarbon or alkoxy radical

R1 is a radical of formula (a), (b) or (c) below:(a) -CO-NR3R4(b) -CO-O-R5(c) -SO2-R5wherein R3 represents a hydrogen atom or a linear or branched, saturated or unsaturated, optionally hydroxylated, C1 to C6 hydrocarbon radical,R4 represents a hydrogen atom or a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C1 to C30 hydrocarbon radical, andR5 represents a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C1 to C30 hydrocarbon radical, in a depigmenting and/or bleaching cosmetic composition for human skin, body hairs or head hair

compositions comprising the derivatives of formula (I) and a process for depigmenting and/or bleaching the skin, body hairs and/or head hairs.

Priority: FR19970010710 Applic. Date: 1997-08-27; WO1998FR01856 Applic. Date: 1998-08-26

Inventor: PHILIPPE MICHEL [FR]; TULOUP REMY [FR]; BLAISE CHRISTIAN [FR]


Patent No.: US6425918B1  Issued: 30/Jul/2002

Title: Polysaccharide sponges for cell culture and transplantation

Applicant/Assignee: BEN GURION UNIVERSITY OF THE NEGEV

Application No.: 09/180970   Filing Date: 17/Nov/1998

Abstract:

A polysaccharide sponge characterized by having: (i) an average pore size in the range between about 10 mum to about 300 mum

(ii) an average distance between the pores being the wall thickness of the pores in the range between about 5 mum to about 270 mum

and (iii) an E-modulus of elasticity being a measure of the rigidity of the sponge in the range of about 50 kPa to about 500 kPa.

Priority: IL19960118376 Applic. Date: 1996-05-22; WO1997IL00161 Applic. Date: 1997-05-21

Inventor: SHAPIRO LILIA [IL]; GLICKLIS RACHEL [IL]; COHEN SMADAR [IL]


Patent No.: US6426060B2  Issued: 30/Jul/2002

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA A DIVISION OF CONOPCO, INC

Application No.: 09/548309   Filing Date: 12/Apr/2000

Abstract:

A cosmetic composition is a structured emulsion of a continuous phase containing water-immiscible liquid carrier plus a structurant, and a disperse phase which is a solution of antiperspirant active in a more polar, probably aqueous, solvent. The structurant is a material which forms a network of fibers in the continuous phase, thereby gelling it. The structurant has an enthalpy of gelation in the carrier liquid or a test liquid with a magnitude of at least 30 kJ/mole. This minimum enthalpy of gelation facilitates processing at conveniently accessible temperatures and promotes stability.

Priority: GB19990008212 Applic. Date: 1999-04-12

Inventor: FRANKLIN KEVIN RONALD [GB]; HOPKINSON ANDREW [GB]


Patent No.: US6426079B1  Issued: 30/Jul/2002

Title: Water-in-oil emulsion, composition comprising such an emulsion, and use thereof

Applicant/Assignee: L'OREAL

Application No.: 09/277207   Filing Date: 26/Mar/1999

Abstract:

The present invention relates to a stable water-in-oil emulsion for cosmetic, pharmaceutical or hygiene use, comprising an aqueous phase and a fatty phase comprising a silicone oil, characterized in that it comprises an emulsifying system comprising at least one alpha,omega-substituted oxyalkylenated silicone of formula (I):in which: R=-(CH2)pO-(C2H4O)x(C3H6O)yR1where:R1 represents H, CH3 or CH2CH3,p is an integer ranging from 1 to 5, x ranges from 1 to 100 and y ranges from 1 to 50,it being possible for the units (C2H4O) and (C3H6O) to be distributed randomly or in blocks,the R2 radicals represent a C1-C3 alkyl radical or a phenyl radical,5<=m<=300,and a co-surfactant chosen from the family of glycol mono- and/or diesters and glyceryl mono-, di- and/or triesters, and mixtures thereof. The invention also relates to a composition comprising the above emulsion, and to its applications in the cosmetics, pharmaceutical, dermatological or hygiene fields.

Priority: FR19980003762 Applic. Date: 1998-03-26

Inventor: BARA ISABELLE [FR]; LEMANN PATRICIA [FR]; TOURNILHAC FLORENCE [FR]; COLLETTE ANNICK [FR]; SIMON JEAN-CHRISTOPHE [FR]


Patent No.: US6426080B1  Issued: 30/Jul/2002

Title: Cosmetic preparation of active substances with high protection factor against free radicals

Applicant/Assignee: COTY, B.V

Application No.: 09/720335   Filing Date: 22/Dec/2000

Abstract:

The disclosed cosmetic preparation of active substances protects the skin in a particularly effective way against free radical aggression, both alone and in combination with other active substances. The preparation consists of a Quebraco blanco bark extract containing at least 90 wt. % proanthocyanidin oligomers, a silkworm extract containing the peptide cecropin, amino acids and a vitamin mixture, a non-ionic, cationic or anionic hydrogel, phospholipids and water, and may also contain further active substances such as vitamin derivatives and plant extracts of acerola, sea weed, citrus, bitter orange, cherry, papaya, tea, coffee beans, Mimosa tenuiflora and angelica. The preparations have protection factors against free radicals of up to 10000, and the cosmetic compositions containing these preparations have protection factors of between 40 and 200, depending on their proportion of the preparations.

Priority: DE19981030004 Applic. Date: 1998-06-24; DE19981060754 Applic. Date: 1998-12-23; WO1999DE01851 Applic. Date: 1999-06-22

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]


Patent No.: US6426435B1  Issued: 30/Jul/2002

Title: Substantive water-soluble bis-quaternary salts of cinnamidoalkylamines

Applicant/Assignee: GALAXY SURFACTANTS LTD

Application No.: 09/917953   Filing Date: 31/Jul/2001

Abstract:

Substantive UV-absorbing water-soluble quaternary salts of cinnamidoalkylamine of formula I. Hair, skin and fabric care compositions containing the compounds of formula I

wherein R1 represents up to four substituents, same or different, selected from H, halo, -OH, -NH2, -NO2, -OCH3, -N(CH3)2, alkyl groups containing up to 6 carbon atoms, alkoxy groups containing up to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing up to 6 carbon atoms

R2 is selected from hydrogen, alkyl group containing up to 6 carbon atoms

R3 and R4 are independently selected from benzyl, alkyl group containing up to 6 carbon atoms

n is an integer from 1 to 6

m is an integer from 1 to 10

X- is a counter anion of quaternary centres selected from halides including chloride, bromide, iodide and methane sulphonate and its derivatives such as trifluoro methane sulphonate, benzene sulphonates including its p-bromo, nitro and methyl derivative.

Priority: IN2000MU00903 Applic. Date: 2000-10-06; IN2000MU00904 Applic. Date: 2000-10-06

Inventor: KOSHTI NIRMAL MADHUKAR [IN]; JAWALE ARUN HARCHANDRA [IN]; PARAB BHARAT BHIKAJI [IN]; NAIK SHUBHANGI DATTARAM [IN]; MOGHE MANASI DATTATRAYA [IN]; JADHAV TANAJI SHAMRAO [IN]; NASHTE SUBHASH SHIVLING [IN]


Patent No.: US6428776B1  Issued: 06/Aug/2002

Title: Aqueous cosmetic preparations in stick form

Applicant/Assignee: COGNIS DEUTSCHLAND GMBH

Application No.: 09/554305   Filing Date: 11/Oct/2000

Abstract:

A cosmetic composition containing: (a) an alkyl and/or alkenyl oligoglycoside corresponding to formula (I):wherein R1 is an alkyl and/or alkenyl radical having from 4 to 22 carbon atoms, G is a sugar radical having 5 or 6 carbon atoms, and p is a number from 1 to 10

(b) an oily compound

(c) a nonionic emulsifier

and (d) an active ingredient selected from the group consisting of an anti-perspirant compound, a deodorant compound, an antibacterial active compound, and mixtures thereof, and wherein the composition is free of soap and natural wax.

Priority: DE19971049819 Applic. Date: 1997-11-11; WO1998EP06896 Applic. Date: 1998-10-30

Inventor: GUCKENBIEHL BERNHARD [DE]; BANOWSKI BERNHARD [DE]; TESMANN HOLGER [DE]


Patent No.: US6428814B1  Issued: 06/Aug/2002

Title: BIOADHESIVE NANOPARTICULATE COMPOSITIONS HAVING CATIONIC SURFACE STABILIZERS

Applicant/Assignee: ELAN PHARMA INTERNATIONAL LTD

Application No.: 09/414159   Filing Date: 08/Oct/1999

Abstract:

Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

Priority:

Inventor: BOSCH H WILLIAM [US]; COOPER EUGENE R [US]; MCGURK SIMON L [US]


Patent No.: US6429224B1  Issued: 06/Aug/2002

Title: USE OF TAUROLIDINE TO TREAT TUMORS

Applicant/Assignee: RHODE ISLAND HOSPITAL, A LIFESPAN PARTNER

Application No.: 09/730923   Filing Date: 06/Dec/2000

Abstract:

The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.

Priority: US19990169122P Applic. Date: 1999-12-06; US19990169127P Applic. Date: 1999-12-06; US19990169128P Applic. Date: 1999-12-06

Inventor: CALABRESI PAUL [US]; DARNOWSKI JAMES [US]


Patent No.: US6429234B2  Issued: 06/Aug/2002

Title: FOAM, AN INTERIOR MATERIAL MADE OF THE FOAM, A MOLDED ARTICLE DESTINED FOR AN INTERIOR VEHICULAR MATERIAL, AND PRODUCTION METHODS THEREOF

Applicant/Assignee: TORAY INDUSTRIES, INC

Application No.: 09/180549   Filing Date: 10/Nov/1998

Abstract:

The object is to obtain a foam, an interior material, and a molded article destined for an interior automotive or other vehicular material which can inhibit the formation of crystals in the fogging test.The present invention is a foam, an interior material and a molded article destined for an interior vehicular material, comprising a fogging inhibitor, to keep the amount of the precipitate detected by the fogging test at 0.8 mg or less.The foam and the interior material obtained according to the present invention can be suitably used as a dash board in front of the driver's seat, an interior material at the door and as an interior material of the ceiling in an automobile.

Priority: JP19970061220 Applic. Date: 1997-03-14; JP19970228112 Applic. Date: 1997-08-25; WO1998JP00950 Applic. Date: 1998-03-09

Inventor: KATAOKA AKIHIRO [JP]; OKUBO SHUNJI [JP]; NAKAE TOSHIHARU [JP]; AKIMARU FUSAYOSHI [JP]


Patent No.: US6429431B1  Issued: 06/Aug/2002

Title: Medical diagnostic method and apparatus utilizing radioactivity detection

Applicant/Assignee:

Application No.: 09/405852   Filing Date: 24/Sep/1999

Abstract:

A medical diagnostic apparatus includes a carrier body, a plurality of rigid substrates each bearing at least one solid-state gamma ray sensor, the substrates being attached to the carrier body, and a computer operatively connected to the sensors for receiving signals therefrom and deriving information about location and size of a source of radioactivity in the patient. The carrier body enables disposition of different gamma ray sensors on different sides of the patient so that the sensors at least partially surround the patient. In an associated medical diagnostic method, a chemical composition containing a radioactive isotope is administered to a patient. A plurality of solid-state sensors sensitive to gamma rays generated by radioactive decay of the isotope are subsequently disposed about the patient, and signals from the sensors are conducted to a computer, which is then operated to derive information about location and size of a source of radioactivity in the patient. The sensors may be mounted to a flexible web which is manipulated to conform to the patient.

Priority:

Inventor: WILK PETER J [US]


Patent No.: US6432407B1  Issued: 13/Aug/2002

Title: Antigenic protein originating in malassezia

Applicant/Assignee: TAKARA SHUZO CO., LTD

Application No.: 09/091097   Filing Date: 12/Jun/1998

Abstract:

A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses

an antigenic fragment derived from the antigenic protein

and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.

Priority: JP19950346627 Applic. Date: 1995-12-12; JP19960257612 Applic. Date: 1996-09-05; JP19960257613 Applic. Date: 1996-09-05; WO1996JP03602 Applic. Date: 1996-12-10

Inventor: TAKESAKO KAZUTOH [JP]; OKADO TAKASHI [JP]; YAGIHARA TOMOKO [JP]; KURODA MASANOBU [JP]; ONISHI YOSHIMI [JP]; KATO IKUNOSHIN [JP]; AKIYAMA KAZUO [JP]; YASUEDA HIROSHI [JP]; YAMAGUCHI HIDEYO [JP]


Patent No.: US6432421B1  Issued: 13/Aug/2002

Title: Emollient compositions with polyethylene beads

Applicant/Assignee: INTERNATIONAL FLORA TECHNOLOGIES, LTD

Application No.: 09/547482   Filing Date: 12/Apr/2000

Abstract:

An emollient composition comprising at least 5-30% by weight polyethylene, 0-60% by weight petrolatum, and 0-50% octyl palmitate. These emollient compositions may be used as emollient carriers for various materials, such as fragrances and pigments or dyes, to be externally applied to the skin. These emollient compositions may be formed into particulate shapes, such as spheres, for subsequent use in cosmetic products.

Priority:

Inventor: BROWN JAMES S [US]; BROWN JAMES H [US]


Patent No.: US6432423B1  Issued: 13/Aug/2002

Title: Use of hyperbranched polymers and dendrimers comprising a particular group as film-forming agent, film-forming compositions comprising same and use particularly in cosmetics and pharmaceutics

Applicant/Assignee: L'OREAL

Application No.: 09/581752   Filing Date: 23/Jun/2000

Abstract:

The invention concerns the use of hyperbranched polymers and dendrimers, comprising at least one group of formula (I) in which: Y represents the oxygen atom or a NH group: and A represents a C1-C12 alkane di-yl group, linear, branched or cyclic, saturated or unsaturated

said group being optionally interrupted by one or several heteroatoms and/or substituted by a function selected among: amino (-NH2): acylamino (-NH-CO-R) in which R represents a C1-C10 alkyl group, linear, branched or cyclic, saturated or unsaturated

carboxylic acid (-COOH), ester (-COOR) in which R represents a C1-C10 alkyl group, linear, branched or cyclic, saturated or unsaturated, as film-forming agent. The invention also concerns a film-forming composition comprising said compound and its use particularly in cosmetics or pharmaceutics.

Priority: FR19970016175 Applic. Date: 1997-12-19; WO1998FR02537 Applic. Date: 1998-11-26

Inventor: MAIGNAN JEAN [FR]; GENARD SYLVIE [FR]


Patent No.: US6432428B1  Issued: 13/Aug/2002

Title: Dry emollient composition composing mono-unsaturated jojoba esters

Applicant/Assignee: INTERNATIONAL FLORA TECHNOLOGIES

Application No.: 09/935015   Filing Date: 21/Aug/2001

Abstract:

Disclosed are dry-feel emollient compositions comprising fatty alcohols, alkyl esters and jojoba wax esters obtained by a novel process of a base catalyzed alcoholysis reaction between jojoba oil and an alcohol, such as isopropyl alcohol. The composition is essentially solid at room temperature, can be provided in various shapes and sizes (especially as particulates such as spheres). These new compositions increase the range of applications for cosmetic compositions by providing an emollient that is more polar and hydrophilic than is found in naturally occurring jojoba oils (jojoba wax esters). These compositions have use in personal care, cosmetic, cosemceutical and pharmaceutical products. Typical materials these compositions may be blended include, but are not limited to, cosmetic oils and waxes, both natural and synthetic, hydrogenated or partially hydrogenated oils, silicone oils, mineral oils, long chain esters, vitamins, long chain fatty acids, alcohols, cosmeceuticals, pigments, botanical extracts, esters and ethers, dimers, trimers, oligomers, polymers, and the like. These compositions may be combined with active ingredients to be delivered by the compositions.

Priority: US1998-010736 Applic. Date: 1998-01-22; US1997-953132 Applic. Date: 1997-10-17

Inventor: ARQUETTE DEMETRIOS JAMES G [US]; BROWN JIM [US]; REINHARDT JOHN [US]


Patent No.: US6432451B1  Issued: 13/Aug/2002

Title: Film coated microbeads containing active compounds and method of making the same

Applicant/Assignee: PACIFIC CORPORATION

Application No.: 09/553653   Filing Date: 21/Apr/2000

Abstract:

Disclosed is a composition for use in dermal application. The composition includes microbeads or chemically stable particles having an internal structure of pores. A chemical compound having a pharmaceutical or cosmetic activity is retained in the internal structure of the porous particles. Each of the particles is coated with at least one of a silicone and a polysiloxane-based compound. Also disclosed is a method of making a composition. A plurality of particles containing a chemical compound in its internal structure is prepared. A coating mixture including at least one of a silicone and a polysiloxane-based compound with a solvent is also prepared. The particles are mixed with the coating mixture, which coats over the particles. The coated particles are subject to drying to evaporate the solvent from the coating mixture.

Priority: KR19990014660 Applic. Date: 1999-04-23

Inventor: LEE JANG YOUNG [KR]; GUAN SOON SANG [KR]; KIM JIN HAN [KR]; PARK JONG WON [KR]; CHOI MOON JAE [KR]; KIM YU CHANG [KR]


Patent No.: US6432452B1  Issued: 13/Aug/2002

Title: Anti-cancer compounds

Applicant/Assignee: PEPLIN BIOTECH PTY. LTD

Application No.: 09/486199   Filing Date: 28/Jul/2000

Abstract:

This invention relates to a compound or group of compounds present in an active principle derived from plants of the species Euphorbia peplus, Euphorbia hirta and Euphorbia drummondii, and to pharmaceutical compositions comprising these compounds. Extracts from these plants have been found to show selective cytotoxicity against several different cancer cell lines. The compounds are useful in effective treatment of cancers, particularly malignant melanomas and squamous cell carcinomas (SCCs). In a preferred embodiment of the invention, the compound is selected from the group consisting of jatrophanes, pepluanes, paralianes and ingenanes, and pharmaceutically-acceptable salts or esters thereof, and more particularly jatrophanes of Conformation II.

Priority: AU1997PO08640 Applic. Date: 1997-08-19; WO1998AU00656 Applic. Date: 1998-08-19

Inventor: AYLWARD JAMES HARRISON [AU]


Patent No.: US6432543B2  Issued: 13/Aug/2002

Title: DECORATIVE COMPONENTS HAVING AN ELASTOMERIC OUTER SURFACE AND METHODS OF MAKING SUCH COMPONENTS

Applicant/Assignee: BASF CORPORATION

Application No.: 09/124328   Filing Date: 29/Jul/1998

Abstract:

The aromatic polyurethane elastomers of the present invention are particularly suited for methods of making objects in a mold cavity. The objects generally include an elastomeric layer formed from an aromatic polyurethane and a foam layer which is subsequently applied to the elastomer. The aromatic elastomer of the present invention lends itself to being precoated with an in-mold coating or being painted after demolding the resulting part.

Priority:

Inventor: HARRISON RICHARD P [US]; OGONOWSKI JOSEPH [US]; PAVLINAC JON P [US]; CHANG L PATRICK [US]


Patent No.: US6432957B1  Issued: 13/Aug/2002

Title: Piperazine derivative

Applicant/Assignee: KOWA CO., LTD

Application No.: 09/893681   Filing Date: 29/Jun/2001

Abstract:

A piperazine compound represented by formula (1):wherein X is -CH2-, -C(O)- or -CH(CH3)-

R1 is a hydrogen atom or alkyl group

and R2 is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group

an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

Priority:

Inventor: KODAMA TATSUHIKO [JP]; TAMURA MASAHIRO [JP]; ODA TOSHIAKI [JP]; YAMAZAKI YUKIYOSHI [JP]; NISHIKAWA MASAHIRO [JP]; DOI TAKESHI [JP]; KYOTANI YOSHINORI [JP]


Patent No.: US6432962B2  Issued: 13/Aug/2002

Title: Benzophenones as inhibitors of IL-1beta and TNF-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD. A/S

Application No.: 09/860492   Filing Date: 21/May/2001

Abstract:

Heteroaryl aminobenzophenones of general formula I inhibit interleukin-1beta and TNF-alpha and may therefore be useful in the therapy of inflammatory diseases and conditions.

Priority: US20000205579P Applic. Date: 2000-05-22

Inventor: HORNEMAN ANNE MARIE [DK]


Patent No.: US6436378B1  Issued: 20/Aug/2002

Title: Composition

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 09/795898   Filing Date: 28/Feb/2001

Abstract:

A composition comprising a cream or lotion base said base further comprisinga. An active agent or mixture thereof which brings about skin lightening, andb. An active agent or mixture thereof which prevents skin from further darkening when exposed to ultraviolet light.

Priority:

Inventor: MAHASHABDE CHHAYA SHIRISH [IN]; AGRAWAL SUNIL SHYAMSUNDER [IN]


Patent No.: US6436379B1  Issued: 20/Aug/2002

Title: Emollient for cuticle treatment and delivery system therefore

Applicant/Assignee: INTERNATIONAL FLORA TECHNOLOGIES LTD

Application No.: 09/527935   Filing Date: 16/Mar/2000

Abstract:

A product for treating and conditioning cuticles using a semi-solid emollient and a complimentary delivery system is disclosed. The emollient could be any semi-solid emollient suitable for cuticle treatment, the emollient preferably including naturally derived botanicals that impart a "dry" feel, and a soothing and softening effect on the cuticle area. Isopropyl jojoba (IPJ) and hydrogenated isopropyl jojoba (HIPJ) esters, hydrogenated jojoba alcohol, jojoba esters, hydrogenated jojoba oil, ethyl macadamiate and other esters, waxes and oils may be used in the emollient to contribute to the "dry" feel and serve as carriers for active materials used to treat cuticles. The semi-solid emollient is retained in a container, preferably in stick form, and is extendable from and preferably retractable into the container, which can be carried by an individual. The container is designed to enable a user to apply the emollient to a cuticle area without touching the emollient with his/her fingertips, thereby preventing application or migration of the emollient to unselected areas.

Priority: US1998-010736 Applic. Date: 1998-01-22; US1997-953132 Applic. Date: 1997-10-17

Inventor: HILL JOHN C [US]; RODRIGUEZ THERESA E [US]; BROWN JAMES H [US]


Patent No.: US6436412B1  Issued: 20/Aug/2002

Title: Use of a hybrid polymeric material for coating keratinous materials

Applicant/Assignee: LOREAL S.A

Application No.: 09/254424   Filing Date: 19/May/1999

Abstract:

The invention relates to the use, for coating keratin substances, of a crosslinked hybrid polymer material which can be obtained from an aqueous solution containing:(a) at least one water-soluble polymer containing at least functional groups capable of forming hydrogen bonds, and(b) at least one organic or inorganic salt, of ammonium or of a monovalent or polyvalent metal cation

and by physical crosslinking of the said polymer resulting from hydrogen interactions between the functional groups of the said polymer and the water molecules in the hydration sphere of the said hydrated cation, for the preparation of cosmetic or dermatological compositions.The invention relates more particularly to the use of the said coating agent for make-up products, in particular foundations, lipsticks, mascaras, eyeliners and care bases for the nails

for hair formulations, in particular styling products and/or products for holding the hair, or alternatively for skincare products.

Priority: FR19970008606 Applic. Date: 1997-07-07; WO1998FR01259 Applic. Date: 1998-06-16

Inventor: QUINN FRANCIS [FR]


Patent No.: US6436433B1  Issued: 20/Aug/2002

Title: Transdermal or topical plaster system with a polyacrylate matrix with improved physical properties

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/367762   Filing Date: 20/Oct/1999

Abstract:

A transdermal or topical plaster system with a backing layer, with an active ingredient-containing and self-adhesive matrix based on crosslinkable polyacrylate as base polymer and with a removable protecting film is characterized by an at least two-layer matrix with a degree of crosslinking of the layer facing the skin which is appropriate for adequate adhesion to the skin thereof and is lower than the degree of crosslinking of the layer or layers on top thereof.

Priority: DE19971006824 Applic. Date: 1997-02-21; WO1998EP00685 Applic. Date: 1998-02-09

Inventor: MUELLER WALTER [DE]


Patent No.: US6436885B2  Issued: 20/Aug/2002

Title: Antimicrobial cleansing compositions containing 2-pyrrolidone-5-carboxylic acid

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/738365   Filing Date: 15/Dec/2000

Abstract:

Disclosed are antimicrobial cleansing compositions that have a pH of from about 2.0 to about 5.5 and comprise an antimicrobial agent, an amphoteric sulfactant, and 2-pyrrolidone-5 carboxylic acid as a proton donating agent. Also disclosed are corresponding articles of manufacture and methods of cleansing the skin using the described compositions. The compositions are mild to the skin and provide improved antimicrobial benefits to the skin.

Priority: US20000177092P Applic. Date: 2000-01-20; US20000177091P Applic. Date: 2000-01-20; US20000191939P Applic. Date: 2000-03-24

Inventor: BIEDERMANN KIMBERLY ANN [US]; MORGAN JEFFREY MICHAEL [US]; WEI KARL SHIQING [US]; SINE MARK RICHARD [GB]; THOMAS CHEYNE P [US]; TARANTINO DAVID EDMUND [US]; IRWIN CHRISTOPHER [US]; PUTMAN CHRISTOPHER DEAN [US]; BEERSE PETER WILLIAM [US]


Patent No.: US6436926B1  Issued: 20/Aug/2002

Title: Compositions and methods for treating superficial fungal infections

Applicant/Assignee: MEDPOINTE, INC

Application No.: 09/945638   Filing Date: 04/Sep/2001

Abstract:

Compositions comprising 4,4'-methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1',1',-tetraoxide and their use in treating dermatologic disorders are disclosed.

Priority: US2000-568635 Applic. Date: 2000-05-10; US19990133283P Applic. Date: 1999-05-10

Inventor: COSTIN JAMES C [US]


Patent No.: US6437002B1  Issued: 20/Aug/2002

Title: Agent for preventing and treating skin diseases

Applicant/Assignee: SHOWA DENKO K.K

Application No.: 09/418317   Filing Date: 14/Oct/1999

Abstract:

The present invention relates to an agent for preventing and treating skin diseases comprising as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity

wherein R1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R2 to R4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.

Priority: JP19980133479 Applic. Date: 1998-05-15; JP19980133480 Applic. Date: 1998-05-15; JP19980133481 Applic. Date: 1998-05-15; JP19980182353 Applic. Date: 1998-06-29; JP19980182354 Applic. Date: 1998-06-29; JP19980182355 Applic. Date: 1998-06-29; WO1999JP02516 Applic. Date: 1999-05-14; US19980104157P Applic. Date: 1998-10-14; US19980104159P Applic. Date: 1998-10-14; US19980104160P Applic. Date: 1998-10-14

Inventor: ITO SHINOBU [JP]; OGATA EIJI [JP]; IKENO HIROSHI [JP]


Patent No.: US6437005B1  Issued: 20/Aug/2002

Title: Active topical skin protectants using polymer coated metal alloys

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY MAINSTREAM ENGINEERING CORPORATION

Application No.: 09/871745   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: HOBSON STEPHEN T [US]; BRAUE JR ERNEST H [US]; BACK DWIGHT [US]


Patent No.: US6440430B1  Issued: 27/Aug/2002

Title: W/O emulsion composition comprising such an emulsion and cosmetic pharmaceutical or hygiene use thereof

Applicant/Assignee: L'OREAL S.A

Application No.: 09/276744   Filing Date: 26/Mar/1999

Abstract:

The present invention relates to a stable water-in-oil emulsion for cosmetic, pharmaceutical or hygiene use, comprising an aqueous phase and a fatty phase comprising a silicone oil, characterized in that it comprises at least one alpha,omega-substituted oxyalkylenated silicone, the emulsion having a viscosity ranging from 100 cps to 200 poises, at 25 DEG C. and at a shear rate of 200 s-1. The invention also relates to the compositions comprising such an emulsion, and to its applications in the cosmetics field.

Priority: FR19980003761 Applic. Date: 1998-03-26

Inventor: BARA ISABELLE [FR]; LEMANN PATRICIA [FR]; TOURNILHAC FLORENCE [FR]; COLLETTE ANNICK [FR]; SIMON JEAN-CHRISTOPHE [FR]


Patent No.: US6440453B1  Issued: 27/Aug/2002

Title: Transdermal systems for release of 5-HT3 receptor antagonists and their use in anti-emetic treatment

Applicant/Assignee: NOVOSIS PHARMA AG

Application No.: 09/602003   Filing Date: 23/Jun/2000

Abstract:

This invention refers to a transdermal system for release of 5-HT3 receptor antagonists which is characterized in that it contains a composition of a 5-HT3 receptor antagonist as an active agent, tea tree oil, a water-miscible solvent and water.

Priority: DE19991029197 Applic. Date: 1999-06-25

Inventor: FISCHER WILFRIED [DE]; STIERLE AXEL [DE]


Patent No.: US6443978B1  Issued: 03/Sep/2002

Title: Photomatrix device

Applicant/Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

Application No.: 09/646824   Filing Date: 22/Sep/2000

Abstract:

A device for the physiotherapeutic irradiation of spatially extensive pathologies by light with the help of a matrix of the sources of optical radiation such as lasers or light diodes placed on the surface of a substrate whose shape is adequate to the shape of the zone of pathology is disclosed. In addition, the device contains stops and a holder to fix the substrate against the bioobject. Additional modules are provided to adjust the temperature, pressure, gas composition over the pathological area. As a source of radiation, chemical reactions accompanied by the luminescence of the products of reaction are suggested. The power supply unit can be autonomous with remote feeding through pulse magnetic field. A supplementary hood optically transparent is provided to localize the pathology as well as the strips that scatter the radiation to get a more uniform bioobject's exposure. Application: light-therapy to treat various extensive pathologies on the bioobject's surface including dermatology, cosmetology

the treatment of traumas, bruises, oedemas, varicose veins, blood therapy, treatment of infectious processes.

Priority: WO1999RU00111 Applic. Date: 1999-04-09; RU19980106764 Applic. Date: 1998-04-10

Inventor: ZHAROV VLADIMIR PAVLOVICH [RU]


Patent No.: US6444195B1  Issued: 03/Sep/2002

Title: Sunscreen compositions containing a dibenzoylmethane derivative

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 09/883416   Filing Date: 18/Jun/2001

Abstract:

The present invention relates to a method of photostabilizing a composition comprising (a) one or more dibenzoylmethane derivative UV-A absorbing agent(s)

(b) one or more benzophenone derivative(s)

and (c) a diester or polyester of a naphthalene dicarboxylic acid and a method of protecting mammalian skin or hair from UV radiation comprising topically applying to the skin or hair such a composition.

Priority:

Inventor: COLE CURTIS [US]; NATTER FLORENCE [US]


Patent No.: US6444213B1  Issued: 03/Sep/2002

Title: Cosmetics with hydrofluoroether (HFE)

Applicant/Assignee: DAIKIN INDUSTRIES LTD

Application No.: 09/486367   Filing Date: 28/Feb/2000

Abstract:

A cosmetic containing at least 1% by weight of hydrofluoroether having a viscosity of less than 5 mPa.s at 25 DEG C., which is represented by the general formula (1):wherein n is a number of 1 to 12, m is a number of 0 to 25, l is a number of 0 to 11, m+l=2n+1, x is a number of 1 to 12, y is a number of 0 to 25, z is a number of 0 to 11, and y+z=2x+1, provided that m and y are not be simultaneously zero, and l and z are not be simultaneously zero, gives no environment disruption, is highly safe for the skin and improves the feeling in use.

Priority: JP19970232891 Applic. Date: 1997-08-28; WO1998JP03499 Applic. Date: 1998-08-06

Inventor: MORITA MASAMICHI [JP]; KUBO MOTONOBU [JP]


Patent No.: US6444647B1  Issued: 03/Sep/2002

Title: Skin care compositions containing combination of skin care actives

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/544791   Filing Date: 07/Apr/2000

Abstract:

The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of a vitamin B3 compound

a safe and effective amount of a skin care active selected from farnesol, phytantriol, and mixtures thereof

and a dermatologically acceptable carrier.

Priority: US2000-541965 Applic. Date: 2000-04-04; US1999-441303 Applic. Date: 1999-11-16; US19990129975P Applic. Date: 1999-04-19; US20000175315P Applic. Date: 2000-01-10

Inventor: ROBINSON LARRY RICHARD [US]; BISSETT DONALD LYNN [US]; DECKNER GEORGE ENDEL [US]; HA ROBERT BAO KIM [US]


Patent No.: US6447792B2  Issued: 10/Sep/2002

Title: Use in cosmetics of a rigid gel, and cosmetic or dermatological compositions used

Applicant/Assignee: L'OREAL LOREAL S.A

Application No.: 09/877134   Filing Date: 11/Jun/2001

Abstract:

The present invention relates to the use in cosmetics of rigid gels containing at least 20% by weight of one or more water-soluble or hydrophilic gelling agent(s) which may be obtained from the said water-soluble or hydrophilic gelling agent in the presence of water by mixing, blending, compression and extrusion in a twin-screw extruder.These gels constitute novel pharmaceutical forms for cosmetic or dermatological use. These gels are generally in the form of sticks, pencils or cakes. They may be aqueous with a matrix consisting of an aqueous gelled network. They may be in anhydrous form with a matrix consisting of a dehydrated gelled network.

They may constitute many products in solid form applied to making up, to care of and/or to treatment of the skin, the scalp, the hair or the mucous membranes, or alternatively applied to the hygiene of the body, the skin, the scalp, the hair or the mucous membranes.

Priority: FR19950013095 Applic. Date: 1995-11-06; US2000-500075 Applic. Date: 2000-02-08; US1998-068196 Applic. Date: 1998-08-20

Inventor: ROULIER VERONIQUE [FR]; MELLUL MYRIAM [FR]; DAUBIGE THERESE [FR]; HOLZ KATRIN [CH]


Patent No.: US6448251B1  Issued: 10/Sep/2002

Title: Zwitterionic-fatty acid compounds having anti-inflammatory properties

Applicant/Assignee:

Application No.: 09/627910   Filing Date: 27/Jul/2000

Abstract:

A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula.wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid moiety, selected from one of the groups consisting of alkanes, alkenes, and alkadienes, each having a hydrocarbon chain of from one to twenty carbon atoms. The resulting HEPES esters are represented by the acetic acid ester as an exemplary alkane, the oleic acid ester as a exemplary alkene, and the linoleic acid ester as an exemplary alkadiene, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties

they occur naturally as glycerides, i.e., esters of glycerol. Also useful are analogs of HEPES/EPES like piperazine-N'-(2-ethane sulfonic acid)

and N-methylpiperazine-N'-(2-ethane sulfonic acid)

, and the piperiodine analog of the piperazine ester.A pharmacologic composition is also provided which comprises at least one amphoteric (Zwitterionic-ester) with a pharmacologically-acceptable topical carrier or base. Other adjunctive pharmaceutical agents may be included to facilitate other than topical administration.Also useful are analogs of HEPES/EPES, like Piperazine-N'(2-ethanesulfonic acid

N-Methylpiperazine -N1(2-ethanesulfonic acid) and the piperidine analog of the piperazine ester.

Priority: US1998-200482 Applic. Date: 1998-11-27; US19970066918P Applic. Date: 1997-11-28

Inventor: PUGLIESE PETER T [US]; PUGLIESE PETER M [US]


Patent No.: US6451293B1  Issued: 17/Sep/2002

Title: COMBINATION OF ERYTHRULOSE AND A REDUCING SUGAR WITH SELF-TANNING PROPERTIES

Applicant/Assignee: PENTAPHARM AG

Application No.: 09/380651   Filing Date: 05/Jan/2000

Abstract:

The invention relates to an active ingredient combination containing erythrulose and a further reducing sugar with self-tanning properties, for example, dihydroxyacetone, which combination is used for artificially tanning the skin. Compared with compounds containing, for example, only dihydroxyacetone, said active ingredient combination and cosmetic compounds based thereon result in an even and longer-lasting colouring of the skin and prevent skin dehydration and uneven flaking.

Priority: CH19970000518 Applic. Date: 1997-03-05; WO1998CH00083 Applic. Date: 1998-02-27

Inventor: SCHREIER THOMAS [CH]; JERMANN ROLAND [CH]


Patent No.: US6451294B1  Issued: 17/Sep/2002

Title: Method and makeup kit containing goniochromatic and monochromatic pigments

Applicant/Assignee: L'OREAL

Application No.: 09/289817   Filing Date: 12/Apr/1999

Abstract:

The present invention relates to a new makeup kit comprising a first, goniochromatic pigment composition which is intended to form a base layer and a second, conventional pigment composition having one of the colors of the first pigment, the second composition being intended to form a surface layer comprising decorative motifs. Depending on the viewing angle, therefore, it is possible to see the said motifs appear or disappear. This kit is intended in particular for making up the nails, lips, cheeks or eyelids, or else the body. The invention also relates to a method of making up the human face, lips or body.

Priority: FR19980004581 Applic. Date: 1998-04-10

Inventor: SIMON JEAN-CHRISTOPHE [FR]


Patent No.: US6451331B1  Issued: 17/Sep/2002

Title: Pleated cosmetic effervescent cleansing pillow

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/651005   Filing Date: 29/Aug/2000

Abstract:

A wiping article is provided which includes an effervescent cleanser composition held within a sachet, at least one wall of the sachet including at least one pleat. The presence of pleats allows expansion room within the sachet to accommodate effervescent action. It also results in an ergonomically pleasant pillow configuration. Advantageously, the sachet is formed of two sheets with the second sheet being relatively more rigid than the first sheet and non-pleated which permits easier graspability by a user's hand. Additionally, at least one of the sheets should be water permeable. In a preferred embodiment, the effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. Skin benefit agents may be included within the composition.

Priority: US20000179295P Applic. Date: 2000-01-31

Inventor: SLAVTCHEFF CRAIG STEPHEN [US]; ZHANG JOANNA HONG [US]; ZNAIDEN ALEXANDER PAUL [US]


Patent No.: US6451333B1  Issued: 17/Sep/2002

Title: Mild, rinse-off antimicrobial liquid cleansing compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/323419   Filing Date: 01/Jun/1999

Abstract:

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active

from about 9% to about 14%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 4:1 to about 1.5:1, and wherein the total anionic surfactant comprises less than about 50% of the ammonium counter cation salt

from about 4% to about 8%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75 and wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid

a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant

form about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer

and mixtures thereof

and from about 35% to about 93.9%, by weight of the cleansing composition, of water

wherein the composition is adjusted to a pH of greater than about 3.5 and less than about 4.5. The invention also encompasses methods for cleansing, removing germs and decreasing the spread of transient Gram negative and Gram positive bacteria using the rinse-off antimicrobial cleansing compositions described herein.

Priority: US1997-869302 Applic. Date: 1997-06-04

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; BARTOLO ROBERT GREGORY [US]; SCHUETTE THERESA ANNE BAKKEN [US]


Patent No.: US6451773B1  Issued: 17/Sep/2002

Title: Chitosan formulation with azelaic acid and other actives for the treatment of acne

Applicant/Assignee: COGNIS CORPORATION

Application No.: 09/539603   Filing Date: 31/Mar/2000

Abstract:

A composition for treating acneiform eruption containing: (a) a chitosan having a molecular weight ranging from about 500,000 to about 5,000,000 g/mole and a degree of deacylation greater than 80%

(b) an acid-form active ingredient for treating acne

and (c) water.

Priority:

Inventor: OESTER DEAN A [US]; WACHTER ROLF [DE]; GATES JEFFREY A [US]


Patent No.: US6455056B1  Issued: 24/Sep/2002

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/547804   Filing Date: 11/Apr/2000

Abstract:

A cosmetic composition contains a water-immiscible carrier liquid and a structurant therefor which is effective to gel the composition upon cooling from a temperature at which the structurant is a mobile solution in the carrier liquid. The carrier liquid may serve as a continuous phase in which a solid or liquid disperse phase is suspended. The structurant is a fully or partially esterified saccharide which contains no more than eight monosaccharide residues and has an enthalpy of gelation in the carrier liquid with a magnitude of at least 45 kJ/mole. This minimum enthalpy of gelation facilitates processing at conveniently accessible temperatures and promotes stability.

Priority: GB19990008212 Applic. Date: 1999-04-12

Inventor: FRANKLIN KEVIN RONALD [GB]; HOPKINSON ANDREW [GB]


Patent No.: US6458345B1  Issued: 01/Oct/2002

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE, USA DIVISION OF CONOPCO, INC

Application No.: 09/848874   Filing Date: 04/May/2001

Abstract:

The sensory attributes and/or visibility of deposits of wax-structured antiperspirant or deodorant sticks in the form of emulsions can vary significantly depending on the formulation employed.A particularly beneficial balance of attributes is obtained in emulsion sticks by employing a composition comprising a continuous phase which comprises from 10 to 35% volatile silicone oil, and from 5 to 15% non-volatile hydrophobic oil, from 40 to 75% of ta disperse aqueous phase which contains from 1 to 35% of an antiperspirant or deodorant active, from 7 to 25% of a wax structurant, from 0.1 to 10% of an emulsifier, and preferably contains up to 5% insoluble particulate materials, %s being by weight based on the composition.

Priority: GB20000011084 Applic. Date: 2000-05-08

Inventor: EMSLIE BRUCE STEVEN [GB]; TURNER GRAHAM ANDREW [GB]


Patent No.: US6458371B1  Issued: 01/Oct/2002

Title: Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin

Applicant/Assignee: MEDGENE, LIMITED

Application No.: 09/205281   Filing Date: 04/Dec/1998

Abstract:

A novel cosmetic composition comprising a known hydroximic acid derivative as the active ingredient, and conventional carriers of the cosmetic composition are disclosed. The cosmetic composition of the invention is suitable for the prevention and/or reduction of the photoaging processes of the skin exposed to UV radiation.

Priority: HU19950003728 Applic. Date: 1995-12-22; US1996-771410 Applic. Date: 1996-12-20

Inventor: FARKAS BEA [HU]; NAGY PETER LITERATI [HU]; VADASZ AGNES [HU]; VIGH LASZLO [HU]


Patent No.: US6461317B1  Issued: 08/Oct/2002

Title: Water hardenable compositions for splints and braces

Applicant/Assignee: ROYCE MEDICAL COMPANY

Application No.: 09/857082   Filing Date: 31/May/2001

Abstract:

An orthopaedic support (50) or product is formed of a doubleknit type fabric material with spaced interwoven layers formed of high strength materials, and an open-work matrix of filaments or threads interconnecting the layers. The fabric may be impregnated with water hardened urethane. Hydroxy propyl methyl-cellulose (HPMC) will also be applied to the doubleknit type material or other casting fabric in sufficient amount to reduce the stickiness of the water hardened urethane. The HPMC may be mixed in with the water surfaces of the doubleknit type material. The orthopaedic support (50) or product is packaged in a water-vapor impermeable package

and is opened. Water is supplied to the fabric when it is applied to the part of the anatomy requiring support. The fabric may be included in a soft goods' support including a water distribution network, and straps (74) to hold the support in place.

Priority: US1998-205677 Applic. Date: 1998-12-04; US1998-088905 Applic. Date: 1998-06-02; WO1999US28346 Applic. Date: 1999-11-30

Inventor: GRIM TRACY E [US]; IGLESIAS JOSEPH M [US]; SPEAKES KELLY M [US]; CAMPOS MICHAEL [US]; PELOTE STEVEN T [US]


Patent No.: US6461597B1  Issued: 08/Oct/2002

Title: Method of treating hair or skin

Applicant/Assignee: DOW CORNING TORAY SILICONE CO., LTD

Application No.: 09/707512   Filing Date: 07/Nov/2000

Abstract:

A cosmetic consists of a cosmetic raw material in the form of an emulsion of silicone or organic oil containing crosslinked particles mixed with other cosmetic raw materials. Its touch on fingers and skin is good, spreading and feel during use are good, and it can also prevent unruly hair, stray hair, and tangling of hair, so hair can easily be arranged. It imparts a fresh, dry feeling without any stickiness. The cosmetic raw material consists of the silicone or organic oil emulsion containing crosslinked particles with a mean particle diameter of 0.05 to 100 mum. Crosslinking is obtained by an hydrosilylation of liquid crosslinkable compositions consisting of (A) organic compounds with at least two aliphatic unsaturated bonds per molecule, (B) silicon containing organic compounds with at least two hydrogen atoms bonded to silicon atoms in each molecule, and (C) hydrosilylation reaction catalysts. The resulting crosslinked particles are contained in the droplets of the silicone oil or the organic oil which have mean particle sizes of 0.1 to 500 mum, and which droplets are in turn dispersed in water.

Priority: JP19990324840 Applic. Date: 1999-11-16

Inventor: MORITA YOSHITSUGU [JP]; KOBAYASHI KAZUO [JP]; MASARU OZAKI [JP]


Patent No.: US6461624B2  Issued: 08/Oct/2002

Title: Skin-protective composition

Applicant/Assignee:

Application No.: 09/446095   Filing Date: 17/Dec/1999

Abstract:

The present invention relates to a protective composition for skin, which protects against bacterial, viral and fungal infections. The compositions comprise a C8-C20 fatty acid, one or more parabens or a combination of these. The compositions of the invention are particularly effective in controlling infections by Methicillin Resistant Staphylococcus aureus (MRSA) as well as other organisms. The invention includes protective hand creams such as barrier hand creams, as well as body lotions, liquid soaps, shampoos, soap bars and creams generally, which are all protective.

Priority: IE19970000463 Applic. Date: 1997-06-20; IE19970000713 Applic. Date: 1997-10-02; WO1998IE00048 Applic. Date: 1998-06-18

Inventor: EGGERS SABINE [IE]; CLAIR JAMES [IE]; VAN DER MEER MICHAEL JOHN [IE]


Patent No.: US6461625B1  Issued: 08/Oct/2002

Title: Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields

Applicant/Assignee: L'OREAL

Application No.: 09/489839   Filing Date: 24/Jan/2000

Abstract:

A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.

Priority: FR19990001145 Applic. Date: 1999-02-02

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6461631B1  Issued: 08/Oct/2002

Title: Biodegradable polymer composition

Applicant/Assignee: ATRIX LABORATORIES, INC

Application No.: 09/442203   Filing Date: 16/Nov/1999

Abstract:

A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

Priority:

Inventor: DUNN RICHARD L [US]; ENGLISH JAMES P [US]


Patent No.: US6461644B1  Issued: 08/Oct/2002

Title: Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods

Applicant/Assignee:

Application No.: 09/070940   Filing Date: 30/Apr/1998

Abstract:

Anesthetizing plastic or other drug delivery polymer system including a hydrophobic polymer and a drug that has an aromatic ring.

Priority: WO1997US04948 Applic. Date: 1997-03-25; US1996-622190 Applic. Date: 1996-03-25; US19970040481P Applic. Date: 1997-03-07

Inventor: JACKSON RICHARD R [US]; WILLIAMS JOHN N [US]


Patent No.: US6464735B2  Issued: 15/Oct/2002

Title: Fluorescent whitening agents

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 09/766984   Filing Date: 22/Jan/2001

Abstract:

The present invention provides new compounds having the formula:in which X is O or, preferably, NH

M is hydrogen, an alkali metal atom, ammonium or a cation formed from an amine

each R1, independently, is an aminoacid residue from which a hydrogen atom on the amino group has been removed

n is 1 or 2

and each R2, independently, is hydrogen, C1-C3alkyl, halogen, cyano, COOR in which R is hydrogen or C1-C3alkyl, CONH-R in which R has its previous significance, SO2NH-R in which R has its previous significance, NH-COR in which R has its previous significance, SO3M in which M has its previous significance or, when n is 1, R2 can also be CO-R3 in which R3 is C1-C3alkyl or phenyl

provided that those compounds are excluded in whicha) X is NH, n is 1 and R2 is SO3M in which M has its previous significance

orb) X is NH, n is 2 and one R2 is SO3M in which M has its previous significance, and the other R2 is hydrogen, methyl or halogen

orc) X is NH, n is 1, R1 is glycine and R2 is H or CO2H

ord) X is NH, n is 2, each R2 is SO3M in which M has its previous significance and the SO3M groups are in 2,5-positions in the phenyl ring and R1 is D,L-alanine, L-valine, L-leucine, L-isoleucine, L-threonine, L-aspartic acid, L-glutamic acid, L-phenylalanine, L-proline, (),L- or glycine. Most of the new class of 4,4'-diaminostilbene-2,2'-disulfonic acid compounds are useful as fluorescent whitening agents, especially for paper.

Priority: GB19970006110 Applic. Date: 1997-03-25; GB19970009980 Applic. Date: 1997-05-17; US1999-381468 Applic. Date: 1999-09-20

Inventor: ROHRINGER PETER [CH]; METZGER GEORGES [FR]; REINEHR DIETER [DE]


Patent No.: US6464990B2  Issued: 15/Oct/2002

Title: NANOEMULSION BASED ON ETHYLENE OXIDE AND PROPYLENE OXIDE BLOCK COPOLYMERS AND ITS USES IN THE COSMETICS, DERMATOLOGICAL AND/OR OPHTHALMOLOGICAL FIELDS

Applicant/Assignee: L'OREAL

Application No.: 09/477715   Filing Date: 05/Jan/2000

Abstract:

A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant comprised of polyethylene oxide and polypropylene oxide blocks, the oily phase comprising at least one oil having a molecular weight of greater than 400 and wherein the ratio by weight of the amount of oily phase to the amount of surfactant ranges from 2 to 10.

Priority: FR19990000031 Applic. Date: 1999-01-05

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6465005B1  Issued: 15/Oct/2002

Title: Inhibition of crystallization in transdermal devices

Applicant/Assignee: AMARIN TECHNOLOGIES S.A

Application No.: 09/509122   Filing Date: 17/May/2000

Abstract:

A steroid is used as an additive in manufacture of a transdermal drug delivery device, to act as a crystallization inhibitor inhibiting crystallization, during storage of the device, of an active drug in the form of a hormone which has a pharmaceutical or physiological effect in use of the device. The crystallization-inhibiting steroid is present in the device in an amount insufficient to provide significant pharmaceutical or physiological effect in use of the device.

Priority: GB19970020470 Applic. Date: 1997-09-25; WO1998GB02880 Applic. Date: 1998-09-24

Inventor: BIALI FABIAN ISAAC [AR]; SCASSO ALEJANDRO FABIO [AR]; STEFANO FRANCISCO JOSE E [AR]


Patent No.: US6465402B1  Issued: 15/Oct/2002

Title: Composition in the form of an oil-in-water emulsion and its uses in particular its cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/579435   Filing Date: 26/May/2000

Abstract:

The present invention relates to an oil-in-water emulsion composition, including: an oily phase dispersed in an aqueous phase

wherein the oily phase includes at least one crosslinked solid organopolysiloxane elastomer having at least one oxyalkylene group

and wherein the aqueous phase includes at least one polymer which is soluble or swellable in water. The present invention also relates to a cosmetic composition containing the above-noted composition, and methods of using. The present invention makes it possible to prepare oil-in-water emulsions which are stable even though they may not contain a conventionally used surfactant, this stability persisting even when the level of oily phase is high. Furthermore, the present invention provides compositions that are advantageously fresh and comfortable during application to the skin, which effects are otherwise not obtained with conventional compositions.

Priority: FR19990006659 Applic. Date: 1999-05-26

Inventor: LORANT RALUCA [FR]


Patent No.: US6468512B1  Issued: 22/Oct/2002

Title: Gel compositions

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 09/718874   Filing Date: 22/Nov/2000

Abstract:

There is provided a clear antiperspirant/deodorant gel composition. The composition is a water-in-oil emulsion having a viscosity about 7,000 cps to about 25,000 cps and a clarity from about 30 NTU or less. The composition further has an antiperspirant active, water, silicone gelling agent, and one or more silicone oils.

Priority:

Inventor: CARMODY WALTER J [US]


Patent No.: US6468514B2  Issued: 22/Oct/2002

Title: Method of preparing particularly skin-compatible cosmetic or dermatological cleansing preparations

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/738250   Filing Date: 15/Dec/2000

Abstract:

The use of one or more cosurfactants (surfactant B) in a mixture with one or more surfactants different from surfactant B (surfactant A) for reducing the binding of surfactant A to the surface of the skin.

Priority: DE19991060766 Applic. Date: 1999-12-16

Inventor: SCHMUCKER ROBERT [DE]; SUGAR MARTIN [DE]


Patent No.: US6468519B1  Issued: 22/Oct/2002

Title: Polyanhydrides with biologically active degradation products

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 09/422294   Filing Date: 21/Oct/1999

Abstract:

Polyanhydrides which degrade into biologically active salicylates and alpha-hydroxy acids and methods of using these polyanhydrides to deliver the salicylates and alpha-hydroxy acids to a host are provided.

Priority: WO1998US18816 Applic. Date: 1998-09-10; US19970058328P Applic. Date: 1997-09-10

Inventor: UHRICH KATHRYN ELIZABETH [US]


Patent No.: US6468549B1  Issued: 22/Oct/2002

Title: Acidic compositions or dermatological composition containing a crosslinked poly (2-acrylamido-2-methylpropanesulfonic acid) neutralized to at least 90%

Applicant/Assignee: L'OREAL

Application No.: 08/885167   Filing Date: 30/Jun/1997

Abstract:

The invention relates to a cosmetic or dermatological composition containing an acidic aqueous medium and at least one crosslinked poly(2-acrylamido-2-methylpropanesulfonic acid) polymer neutralized to at least 90%. The composition contains, distributed randomly:(a) from 90 to 99.9% by weight of units of formula (1)

andin which X+ denotes a cation or a mixture of cations, it being possible for at most 10 mol % of the cations X+ to be protons H+

(b) from 0.01 to 10% by weight of crosslinking units originating from at least one monomer having at least two olefinic double bonds

the proportions by weight being defined with respect to the total weight of the polymer. The invention also relates to the use of this composition in the cosmetic treatment of keratinous substances, in particular of the skin, hair and mucous membranes, and in particular to a non-therapeutic process for depigmentation of the skin.

Priority: FR19960008108 Applic. Date: 1996-06-28

Inventor: DUPUIS CHRISTINE [FR]; HANSENNE ISABELLE [FR]; MAUBRU MIRELLE [FR]; SEBILLOTE-ARNAUD LAURENCE [FR]; LORANT RALUCA [FR]


Patent No.: US6468552B1  Issued: 22/Oct/2002

Title: Stabilized compositions containing oxygen-labile active agents

Applicant/Assignee: NEUTROGENA CORPORATION

Application No.: 09/586583   Filing Date: 02/Jun/2000

Abstract:

The present invention relates to a composition (e.g., a cosmetic composition) comprising, (a) an oxygen labile active agent, (b) erythorbic acid or a cosmetically acceptable salt or ester thereof, (c) optionally, a tocopherol derivative, (d) optionally, a pantothenic acid derivative, and (e) optionally, an extract of green tea, provided that said composition comprises a compound selected from both (c) and (d), both (c) and (e), or both (d) and (e).

Priority:

Inventor: STAHL CHRIS R [US]; FERNANDEZ ALDO O [US]; WOODIN FREDERICK W [US]


Patent No.: US6469061B1  Issued: 22/Oct/2002

Title: JASMONATE PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER

Applicant/Assignee: RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL DEVELOPMENT LIMITED

Application No.: 09/825347   Filing Date: 04/Apr/2001

Abstract:

A pharmaceutical composition useful for the treatment of cancer in mamnmals, comprising as the active ingredient a therapeutically effective amount of a jasmonate of the formula:wherein:n is 0,1, or 2

R1 is OH, alkoxy, O-glucosyl, or imino

R2 is OH, O, alkoxy or O-glucosyl

R3, R4 and R5 are H, OH, alkoxy or O-glucosyl

and/or wherein R1 and R2, or R1 and R4 together form a lactone

and further wherein the bonds between C3:C7, C4:C5, and C9:C10 may be double or single bonds

or a derivative of said formula

the derivative having at least one of the following: a lower acyl side chain at C3 (free acid, ester or conjugate)

a keto or hydroxy (free hydroxy or ester) moiety at the C6 carbon

or an n-pentenyl or n-pentyl side chain at C7. These jasmonates are useful in treating a wide variety of malignancies.

Priority:

Inventor: FLESCHER ELIEZER [IL]; FINGRUT ORIT [IL]


Patent No.: US6471972B1  Issued: 29/Oct/2002

Title: Cosmetic treatment method for fighting against skin ageing effects

Applicant/Assignee: LVMH RECHERCHE

Application No.: 09/701341   Filing Date: 28/Nov/2000

Abstract:

The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal baseal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis. The application is for the preparation of cosmetic compositions with anti-wrinkle activity.

Priority: FR19960013585 Applic. Date: 1996-11-07; FR19980006822 Applic. Date: 1998-05-29; WO1999FR01261 Applic. Date: 1999-05-28; US1999-297679 Applic. Date: 1999-05-06

Inventor: BONTE FREDERIC [FR]; DUMAS MARC [FR]; HEUSELE CATHERINE [FR]; LE BLAY JACQUES [FR]


Patent No.: US6471997B1  Issued: 29/Oct/2002

Title: Iridaceae extract and compositions containing it

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 08/709658   Filing Date: 09/Sep/1996

Abstract:

The subject of the present invention, in its most general aspect, is an extract of cells of at least one plant of the Iridaceae family, the said plant being obtained by in vitro culture. The subject of the invention is also compositions containing an extract of cells of at least one plant of the Iridaceae family, the use of the said extracts as antagonist of CGRP and/or of substance P and a process of cosmetic treatment involving one of the said compositions.

Priority: FR19950010487 Applic. Date: 1995-09-07; FR19950010486 Applic. Date: 1995-09-07; FR19960003815 Applic. Date: 1996-03-27

Inventor: BRETON LIONEL [FR]; MARTIN RICHARD [FR]; DE LACHARRIERE OLIVIER [FR]


Patent No.: US6472437B1  Issued: 29/Oct/2002

Title: Active topical skin protectants

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/871743   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: BRAUE JR ERNEST H [US]; HOBSON STEPHEN T [US]; LEHNERT ERICH K [US]


Patent No.: US6472438B1  Issued: 29/Oct/2002

Title: Active topical skin protectants containing S-330

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/872095   Filing Date: 01/Jun/2001

Abstract:

A topical skin protectant formulation containing a barrier cream and a reactive moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and a reactive moiety that serves to neutralize chemical warfare agents into less toxic agents.

Priority: US20000209337P Applic. Date: 2000-06-02

Inventor: BRAUE JR ERNEST H [US]; MERSHON MILLARD M [US]; BRAUE CATHERINE R [US]; WAY RUTH A [US]


Patent No.: US6475500B2  Issued: 05/Nov/2002

Title: Anhydrous cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/850892   Filing Date: 08/May/2001

Abstract:

An anhydrous skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin conditioning agent and a volatile siloxane. Inclusions of the select elastomers provide improved uniform distribution of the pigments.

Priority: US20000217040P Applic. Date: 2000-07-10

Inventor: VATTER MICHAEL LEE [US]; SUNKEL JORGE MAX [US]; MOTLEY CURTIS BOBBY [US]


Patent No.: US6476254B1  Issued: 05/Nov/2002

Title: Alkoxylated fatty alcohol dicarboxylic acid esters

Applicant/Assignee: CRODA INC

Application No.: 09/410585   Filing Date: 01/Oct/1999

Abstract:

Fatty alkoxylated esters consisting of diesters of aliphatic or aromatic dicarboxylic acids, formed by reacting the acid with a stoichiometric excess of one or more polyalkoxylated fatty alcohols. Non-aqueous compositions for topical application are also disclosed including one or more active ingredients, and an emollient agent of the fatty alkoxylated esters of the present invention.

Priority: US19980102777P Applic. Date: 1998-10-02

Inventor: PEREIRA ABEL G [US]; OBUKOWHO PATRICK [US]


Patent No.: US6477410B1  Issued: 05/Nov/2002

Title: Electrokinetic delivery of medicaments

Applicant/Assignee: BIOPHORETIC THERAPEUTIC SYSTEMS, LLC

Application No.: 09/584138   Filing Date: 31/May/2000

Abstract:

An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

Priority:

Inventor: HENLEY JULIAN L [US]; CHANG KUO WEI [US]; POTTER JOSEPH [US]; GOLDBERG DENNIS I [US]; PORTER CHRISTOPHER H [US]; PORCELLI V LORENZO [US]


Patent No.: US6479060B1  Issued: 12/Nov/2002

Title: Elegant hydrogenated castor oil ointments

Applicant/Assignee: HEALTHPOINT, LTD

Application No.: 09/945903   Filing Date: 04/Sep/2001

Abstract:

A topical ointment pharmaceutical composition that uses a lipophilic base, a pharmaceutical active and, dispersed in the base, from about 1% to about 50% by weight of the total composition of hydrogenated non-melted castor oil in powder form. The result of using hydrogenated non-melted castor oil in powder form is a surprising pharmaceutical elegance perceived to be smoother in texture and more spreadable than an ointment made by melting the hydrogenated castor oil.

Priority:

Inventor: JONES DAVID P [US]; HOBSON DAVID W [US]; DUQUE PILAR P [US]


Patent No.: US6479461B1  Issued: 12/Nov/2002

Title: Use of alkylmonoglucosides as molecular vectors

Applicant/Assignee: ULICE

Application No.: 09/509078   Filing Date: 14/Jun/2000

Abstract:

The invention concerns the use as molecular vector in pharnaceutical, cosmetic and food products of alkylmonoglucosides of general formula (I) in which R1 is a linear or branched C2-C18 alkyl radical.

Priority: FR19970011766 Applic. Date: 1997-09-22; WO1998FR02028 Applic. Date: 1998-09-22

Inventor: BOUSQUET MARIE PIERRE [FR]; WILLEMONT RENE-MARC [FR]; MONSAN PIERRE [FR]; BOURES EMMANUEL [FR]; MESSAGER ARNAUD [FR]


Patent No.: US6482420B2  Issued: 19/Nov/2002

Title: Composition having bactericidal action, cosmetics containing said composition and ultraviolet ray screening agent

Applicant/Assignee: NOBORU HUZIWARA HUZIWARA NOBORU YAMAZAKI TAKESHI SATO YUKO

Application No.: 09/747972   Filing Date: 27/Dec/2000

Abstract:

A composition having a bactericidal action is provided which has no toxicity to the human body, and particularly a composition having a bactericidal action is provided which exhibit an excellent therapeutic effect for skin diseases such as atopic dermatitis, acne or the like.A composition, in which an extract from a silk gland and/or a liquid silk is an active ingredient, has a bactericidal action to make renewal of a skin cell, exhibiting an excellent therapeutic effect for skin diseases.

Priority:

Inventor: OZEKI HIROSHI [JP]


Patent No.: US6482423B1  Issued: 19/Nov/2002

Title: Antimicrobial wipes which provide improved residual benefit versus gram positive bacteria

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/534732   Filing Date: 27/Mar/2000

Abstract:

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5

and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

Priority: US19990129143P Applic. Date: 1999-04-13

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; SCHUETTE THERESA ANNE BAKKEN [US]; CEN RAYMOND WEI [US]; CLAPP MANNIE LEE [US]; WARREN RAPHAEL [US]


Patent No.: US6482433B1  Issued: 19/Nov/2002

Title: Encapsulation of active ingredients

Applicant/Assignee: GIVAUDAN SA

Application No.: 09/606518   Filing Date: 29/Jun/2000

Abstract:

A process for preparing free-flowing and, during handling, dust-free microparticles. The particles are at least 90% by weight, have a diameter of 100-400 mum, and contain one or more active ingredients in a glassy matrix. Generally, the process of the invention comprises the steps of (1) preparing an aqueous solution of the matrix materials, (2) mixing the flavor into the aqueous solution with stirring to form an emulsion or suspension, (3) spraying the emulsion in a spray drying tower under a supply of hot air to quickly create a semi-solid skin allowing outtake of moisture (water), and (4) subsequently subjecting the resulting particles to continued drying at lower temperatures in a fluid bed.

Priority: EP19990112446 Applic. Date: 1999-06-30

Inventor: DEROOS KRIS BART [CH]; PERREN MATTHIAS [CH]; SHERMAN GREGORY ALAN [US]


Patent No.: US6482455B1  Issued: 19/Nov/2002

Title: Natural source composition for the control of post-harvest pathologies and methods of application

Applicant/Assignee: INABONOS S.A

Application No.: 09/710755   Filing Date: 09/Nov/2000

Abstract:

The composition contains a fundamental active ingredient consisting of the association of thymol, eugenol and cinnamaldehyde, a secondary active ingredient consisting of the association of cuminaldehyde, geraniol, vanillin, borneol, menthol, anethole, terpineol, limonene and different glycosides contained in the essences of mustard and jasmine, a surface-active selected among the different families accepted as emulsifying food additives and an oligosaccharide selected among the mono-oligosaccharides, fructo-oligosaccharides, phyco-oligosaccharides proceeding from algae extracts or vegetable tissue. The composition that has just been described is applied to fruit and vegetables in a diluted bath or in solid form incorporated into the waxes that are usually used in post-harvest treatments.

Priority: ES19990002472 Applic. Date: 1999-11-11

Inventor: FREIRE JOSE MARIA GARCIA-MINA [ES]; IMAZ SANTIAGO CENOZ [ES]; CABTERA RODRIGO GARCIA [ES]; ARREGUI ANGEL MA ZAMARRENO [ES]


Patent No.: US6482604B2  Issued: 19/Nov/2002

Title: Non-or minimally invasive monitoring methods using particle delivery methods

Applicant/Assignee: POWDERJECT RESEARCH LIMITED

Application No.: 09/803828   Filing Date: 12/Mar/2001

Abstract:

Methods for sampling an analyte present in a biological system are provided. The methods entail use of particle delivery methods to obtain a sample of an analyte of interest from the system.

Priority: US1999-390068 Applic. Date: 1999-09-03; US19980099157P Applic. Date: 1998-09-04

Inventor: KWON SUNG YUN [US]


Patent No.: US6482839B1  Issued: 19/Nov/2002

Title: Pyridine-thiols for treatment of a follicular dermatosis

Applicant/Assignee: CELLEGY PHARMACEUTICALS, INC

Application No.: 09/145822   Filing Date: 02/Sep/1998

Abstract:

This invention provides compositions and methods for treatment of skin and mucous membranes suffering from a follicular dermatosis. The compositions include one or more pyridine-thiols and tautomers with attached metallic moieties. Administration of the compounds to aging skin and mucous membranes in topical formulations, either as the only active ingredient or in combination with other known active ingredients to treat a follicular dermatosis. Additional compositions for treating follicular dermatosis contain one or more sulfides and oxides of these same metallic ions, either alone or in combination with other molecules. Topical formulations containing both a pyridine-thiol and tautomers with attached metallic moiety and a metallic sulfide and/or metallic oxide effectively treat skin and mucous membranes suffering from a follicular dermatosis.

Priority: WO1998US11270 Applic. Date: 1998-06-02; US1998-089302 Applic. Date: 1998-06-01; US19970047360P Applic. Date: 1997-06-02; US19970056282P Applic. Date: 1997-09-03; US19970058752P Applic. Date: 1997-09-12; US19970056290P Applic. Date: 1997-09-03

Inventor: THORNFELDT CARL R [US]


Patent No.: US6485717B1  Issued: 26/Nov/2002

Title: ANHYDROUS ANTIPERSPIRANT AND DEODORANT COMPOSITIONS CONTAINING SOLID, ENCAPSULATED, D-PANTOTHENATE SALTS

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/996508   Filing Date: 28/Nov/2001

Abstract:

Disclosed are anhydrous antiperspirant and deodorant compositions comprising from about 0.1% to about 30% by weight of an underarm active (antiperspirant and/or deodorant active)

from about 0.01% to about 10% by weight of a solid, encapsulated, water-soluble, d-pantothenate salt such as calcium pantothenate

from about 0.1% to about 40% by weight of a suspending agent

and from about 10% to about 99% by weight of an anhydrous carrier liquid. Also disclosed are methods of controlling perspiration wetness and/or odor through the topical application to the underarm, especially shaven underarms, of an underarm active and a solid pantothenate salt. The anhydrous compositions are mild to the skin and can help sooth or heal skin irritated or damaged underarm skin, especially when such irritation and damage is the result of occasional or routine shaving of the underarmn.

Priority: US2001-799367 Applic. Date: 2001-03-05

Inventor: SCAVONE TIMOTHY ALAN [US]; SCHLAGHECK BENJAMIN SCOTT [US]; CASSIERE KELLY LYNN [US]


Patent No.: US6485732B1  Issued: 26/Nov/2002

Title: Topical composition comprising a cyclic imidocarbonate-based cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/091748   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a cyclic imidocarbonate bonding agent having the structurewherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and R represents NH or O

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010274034P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6485950B1  Issued: 26/Nov/2002

Title: Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions

Applicant/Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Application No.: 09/617118   Filing Date: 14/Jul/2000

Abstract:

The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase extracted from the plant Potentilla atrosanguinea Lodd. Var. orgyrophylla, said isozyme having the following characteristics, O2- scavenging activity remains same before and after autoclaving

scavenges O2- from sub-zero temperature of -20 DEG C. to high temperature of +80 DEG C.

O2- scavenging activity at 25 DEG C. for 30 days without adding any stabilizing agent such as polyols or sugars

O2- scavenging activity in the presence of saline (0.9% sodium chloride) to 61.8% of the control (without 0.9% sodium chloride), stable at 4 DEG C. for at least 8 months

contamination free and infection free from any living micro- and/or macro-organism after autoclaving

possesses temperature optima at 0 DEG C.

possesses a molecular weight of 33 kD under non-denaturating conditions

possesses a molecular weight of 36 kD under denaturating conditions

has clear peaks in UV range at 268 and 275 nm

has an enzyme turnover number of 19.53x104% per nmol per min at 0 DEG C.

and requires Cu/Zn as a co-factor, method for the preparation of the purified isozyme of autoclavable superoxide dismutase and formulations containing the said autoclavable superoxide dismutase.

Priority:

Inventor: KUMAR SANJAY [IN]; SAHOO RASHMITA [IN]; AHUJA PARAMVIR SINGH [IN]


Patent No.: US6488646B1  Issued: 03/Dec/2002

Title: Swab deliverable actives

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA

Application No.: 09/950855   Filing Date: 12/Sep/2001

Abstract:

A swab product is provided which includes a swab defined by an elongate stem and a fibrous absorbent covering such as cotton on at least one end of the stem. The fibrous absorbent covering is held together by a film-forming polymer. A treatment agent is provided which includes an active agent in a carrier. Particularly preferred is a highly viscous hydrophobic treatment composition such as petrolatum serving as a carrier for actives such as bacitracin ointment.

Priority:

Inventor: ZYGMONT JOSEPH FRANK [US]


Patent No.: US6488916B1  Issued: 03/Dec/2002

Title: Skin care compositions

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC

Application No.: 10/103924   Filing Date: 22/Mar/2002

Abstract:

Disclosed are skin care compositions that are emulsion formulations comprising an aqueous phase, an oil phase, at least one emulsifier, and an epichlorohydrin cross-linked glyceryl starch.

Priority: US2001-813614 Applic. Date: 2001-03-21

Inventor: FOWLER KEVIN [US]


Patent No.: US6488940B2  Issued: 03/Dec/2002

Title: USE OF 17-ALPHA-ESTRADIOL FOR THE TREATMENT OF AGED OR SUNDAMAGED SKIN AND/OR SKIN ATROPHY

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 09/131549   Filing Date: 10/Aug/1998

Abstract:

The present invention relates to a method for treatment of mammalian skin conditions where stimulated connective tissue synthesis is beneficial, comprising treating skin in need of such treatment with a safe and effective amount of 17-alpha-estradiol.

Priority: US19970056485P Applic. Date: 1997-08-21; US1998-129645 Applic. Date: 1998-08-05

Inventor: GENDIMENICO GERARD J [US]; MEZICK JAMES A [US]


Patent No.: US6488941B1  Issued: 03/Dec/2002

Title: Oil-in-water emulsions containing high wax content and a softpaste oily phase

Applicant/Assignee: L'OREAL

Application No.: 09/459990   Filing Date: 14/Dec/1999

Abstract:

A composition in the form of an oil-in-water (o/w) emulsion containing an oily phase dispersed in an aqueous phase, which contains a mixture of nonionic emulsifiers, the mixture being liquid at ambient temperature and having an HLB ranging from about 6 to 13, and in that the oily phase comprises at least about 5% by weight of one or more waxes based on the total weight of the composition, at least one of the waxes having a starting melting temperature of greater than or equal to about 50 DEG C.

Priority: FR19980015763 Applic. Date: 1998-12-14

Inventor: BURNIER VERONIQUE [FR]; ROULIER VERONIQUE [FR]


Patent No.: US6488943B1  Issued: 03/Dec/2002

Title: Antimicrobial wipes which provide improved immediate germ reduction

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/535250   Filing Date: 27/Mar/2000

Abstract:

The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active

from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant

from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent

and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water

wherein the composition is adjusted to a pH of from about 3.0 to about 6.0

wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3

and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

Priority: US19990129079P Applic. Date: 1999-04-13

Inventor: BEERSE PETER WILLIAM [US]; MORGAN JEFFREY MICHAEL [US]; BAIER KATHLEEN GRIESHOP [US]; SCHUETTE THERESA ANNE BAKKEN [US]; CEN RAYMOND WEI [US]


Patent No.: US6488947B1  Issued: 03/Dec/2002

Title: Topical composition comprising a functional aromatic derivative cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/091731   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functional aromatic derivative bonding agent having a structure selected from the group consisting ofwhereinX is one or more cosmetic benefit agents that may or may not be attached to a chemical linker

Y, Z, and W are selected from the group consisting of H, NO2, CN, CF3, SO2R, COR, and X

V is selected from the group consisting of F, I, Br, Cl, NO2, SOPh, N3, Oar, OSO2R, OR, SR, and NH2

V'' and Y'' are selected from the group consisting of C, N, and combinations thereof

Z'' and W'' are selected from the group consisting of F, I, Br, Cl, H, SR, X, or combinations thereof

wherein R is an alkyl or phenyl

andb) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010274165P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6488952B1  Issued: 03/Dec/2002

Title: Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system

Applicant/Assignee:

Application No.: 09/941378   Filing Date: 28/Aug/2001

Abstract:

A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic applications is provided which includes a biocompatible semisolid delivery system and a biocompatible combination semisolid, multiparticulate delivery system for injection, deposition, or implantation within the body to facilitate local or systemic therapeutic effects through the actions of incorporated medicaments or actions inherit to the system.

Priority:

Inventor: KENNEDY JOHN P [US]; JONES II CURTIS E [US]


Patent No.: US6489275B1  Issued: 03/Dec/2002

Title: Skin cleansing agent

Applicant/Assignee: STOCKHAUSEN GMBH & CO. KG

Application No.: 09/665418   Filing Date: 20/Sep/2000

Abstract:

The present invention relates to an agent for cleansing the skin, containing a liquid natural and/or synthetic water-based latex emulsion excluding styrene-butadiene latices, exclusively at least one organic solvent which has a lower volatility than ethanol and a boiling point >78.32 DEG C., and water.

Priority: DE20001040884 Applic. Date: 2000-08-18

Inventor: VEEGER MARCEL [DE]; KLOTZ ANDREAS [DE]; NAUELS BERND [DE]


Patent No.: US6491902B2  Issued: 10/Dec/2002

Title: CONTROLLED DELIVERY SYSTEM FOR HAIR CARE PRODUCTS

Applicant/Assignee: SALVONA LLC

Application No.: 09/771752   Filing Date: 29/Jan/2001

Abstract:

The present invention is a controlled delivery system that can be incorporated in hair care products such as shampoos, conditioners, hair styling products, and other hair care products to effectively deliver a broad range of active agents and sensory markers, such as fragrances or cooling agents onto the hair. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance "burst" upon blow drying the hair or other types of heat treatment. The controlled delivery system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns.

The nano-particle comprises hydrophobic polymers and co-polymers, cationic charge boosters in conjunction with cationic surface-active conditioning agents that assist in adhering the particles onto hair. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.

Priority:

Inventor: SHEFER ADI [US]; SHEFER SHMUEL DAVID [US]


Patent No.: US6491932B1  Issued: 10/Dec/2002

Title: Composition and process for making up keratin substances

Applicant/Assignee: L'OREAL S.A

Application No.: 09/655841   Filing Date: 06/Sep/2000

Abstract:

A cosmetic make-up composition comprising, in a cosmetically acceptable medium, a dyestuff comprising glass particles coated with at least one metallic coat. The invention also relates to a cosmetic process for making up keratin substances. The make-up obtained can have a sparkling and wear-resistant metallic appearance.

Priority: FR19990011174 Applic. Date: 1999-09-07

Inventor: RAMIN ROLAND [FR]; BRENNE INGRID [FR]


Patent No.: US6491933B2  Issued: 10/Dec/2002

Title: Personal care articles comprising hotmelt compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/785882   Filing Date: 16/Feb/2001

Abstract:

The present invention relates to a substantially dry, disposable personal care article suitable for cleansing, said article comprising:a) a water insoluble substrate comprising a creped nonwoven layer

andb) a cleansing component disposed adjacent to said creped nonwoven layer, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactantand wherein the cleansing component exhibits a log [(eta @ 25 DEG C.)/(eta @ 200 DEG C.)] greater than about 0.45.Additionally, the present invention relates to a similar article that is characterized by a cleansing component that exhibits a complex viscosity measured under an oscillation stress of 1 Pa of greater than about 100 Pa.s. at 25 DEG C.

The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit component in addition to or in lieu of the cleansing component.These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invention further relates to methods of cleansing and conditioning the skin and hair utilizing the articles of the present invention.

Priority: US1999-443741 Applic. Date: 1999-11-19; US19990146747P Applic. Date: 1999-08-02

Inventor: LORENZI MARC PAUL [GB]; SMITH III EDWARD DEWEY [US]; PHIPPS NICOLA JACQUELINE [GB]


Patent No.: US6491934B1  Issued: 10/Dec/2002

Title: Topical composition comprising a diazonium salt-based cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/091741   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a diazonium salt bonding agent having the structurewherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273931P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6491935B1  Issued: 10/Dec/2002

Title: Topical composition comprising a 1,2-heteroatom constituted diene cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/091747   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a 1,2-heteroatom constituted diene bonding agent having the structure:wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker, Y represents N, CH, or CW wherein W is an alkyl and R represents O, S, or Se

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273856P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6491941B1  Issued: 10/Dec/2002

Title: Use of at least one lipid extract obtained from the fruit seed of the mirabelle tree

Applicant/Assignee: LABORATOIRES SEROBIOLOGIQUES (SOCIETE ANONYME)

Application No.: 09/720456   Filing Date: 26/Dec/2000

Abstract:

The aim of the invention is to use at least one lipid extract obtained from the fruit seeds of the mirabelle tree as an agent for preparing a cosmetic product for locally active (topical) use for skin and hair, lips, mucous membranes and/or appendages of the skin.

Priority: WO1999EP04383 Applic. Date: 1999-06-24; FR19980008186 Applic. Date: 1998-06-25

Inventor: PAULY GILLES [FR]


Patent No.: US6491953B1  Issued: 10/Dec/2002

Title: Controlled release compositions and method

Applicant/Assignee: AMCOL INTERNATIONAL CORPORATION

Application No.: 09/479764   Filing Date: 07/Jan/2000

Abstract:

A controlled release composition comprising an adsorbent polymer, an active agent, and a release retardant is disclosed. The composition has an improved ability to release the active agent over an extended time period.

Priority:

Inventor: SOJKA MILAN F [US]; SPINDLER RALPH [US]


Patent No.: US6492326B1  Issued: 10/Dec/2002

Title: Skin care compositions containing combination of skin care actives

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/544789   Filing Date: 07/Apr/2000

Abstract:

The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of amount of a peptide active selected from the group consisting of pentapeptides, derivatives of pentapeptides, and mixtures thereof

a safe and effective amount of at least one additional skin care active

and a dermatologically acceptable carrier.

Priority: US2000-541965 Applic. Date: 2000-04-04; US1999-441303 Applic. Date: 1999-11-16; US19990129975P Applic. Date: 1999-04-19; US20000175315P Applic. Date: 2000-01-10

Inventor: ROBINSON LARRY RICHARD [US]; BISSETT DONALD LYNN [US]; DECKNER GEORGE ENDEL [US]; HA ROBERT BAO KIM [US]


Patent No.: US6492395B1  Issued: 10/Dec/2002

Title: Topical formulation of alkyl-, phenyl-pyridone

Applicant/Assignee: MEPHA AG

Application No.: 09/787474   Filing Date: 23/May/2001

Abstract:

A pharmaceutically acceptable topical formulation for the treatment and/or prevention of skin ailments, more particularly of fibriotic nature such as fibriotic lesional tissues, contiguous warts, contact dermatitis, and keloids, and to assist the healing of burns after surgery, comprising as active ingredient a substituted pyridone of the formula: n-(R1)-R2-2-(1H)pyridone or a pharmaceutically acceptable salt or ester thereof, where R1 is selected from methyl, ethyl, propyl, carboxyl and a carboxymethyl or carboxyethyl ester group, R2 is selected from phenyl, methylphenyl, ethylphenyl, propylphenyl, and a carboxyphenyl or carboxyethylphenyl ester group, and n is 3, 4 or 5, together with an excipient, characterized in that the excipient comprises, one or more plasticisers, one or more antioxidants, one or more gel-forming agents and sufficient pH adjusting agent to bring the pH of the formulation to a value from 4 to 8. The preferred active ingredient is 5-methyl-1-phenyl-2-(1H)pyridone (Pirfenidone).

Priority: WO1998EP05971 Applic. Date: 1998-09-18

Inventor: SCHEIWE MAX WERNER [DE]; YAMAUCHI SHITOTOMO [JP]


Patent No.: US6492503B1  Issued: 10/Dec/2002

Title: Glycosaminoglycan and drug compositions containing the same

Applicant/Assignee: SEIKAGAKU CORPORATION

Application No.: 09/509478   Filing Date: 22/May/2000

Abstract:

There is provided a glycosaminoglycan having a backbone structure comprising a repetitive disaccharide bearing a uronic acid residue and a glucosamine residue, and having sulfate groups, wherein substantially no sulfate group bound to the hydroxyl group at the 6-position of the glucosamine residue in the backbone structure is detected as determined by a chemical disaccharide analysis method in which the glycosaminoglycan is decomposed with nitrous acid, reacted with para-nitrophenylhydrazine and analyzed by high performance liquid chromatography, and the molar % of a uronic acid residue having a sulfate group at the 2-position is not less than 45% relative to total uronic acid residues, which is calculated from a disaccharide composition obtained by an enzymatic disaccharide analysis method in which the glycosaminoglycan is digested with glycosaminoglycan-degrading enzymes and analyzed by high performance liquid chromatography. The glycosaminoglycan can be used as an active ingredient of pharmaceuticals.

Priority: JP19980217051 Applic. Date: 1998-07-31; JP19980246387 Applic. Date: 1998-08-31; WO1999JP04155 Applic. Date: 1999-08-02

Inventor: KARIYA YUTAKA [JP]; TAKANO RYO [JP]; KAMEI KAEKO [JP]; HARA SABURO [JP]; ONAYA JUNICHI [JP]; HORI YUSUKE [JP]


Patent No.: US6494856B1  Issued: 17/Dec/2002

Title: Swab deliverable actives

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/950858   Filing Date: 12/Sep/2001

Abstract:

A swab product is provided which includes a swab defined by an elongate stem and a fibrous absorbent covering such as cotton on at least one end of the stem. The fibrous absorbent covering is held together by a film-forming polymer. A treatment composition is dispersed onto the fibrous absorbent covering. Particularly preferred is a highly viscous hydrophobic treatment composition consisting of at least about 80% of petrolatum, which may serve to deliver actives such as bacitracin ointment or by itself serve as an occlusive therapeutic covering of skin to prevent infection.

Priority:

Inventor: ZYGMONT JOSEPH FRANK [US]


Patent No.: US6495147B1  Issued: 17/Dec/2002

Title: Uses of D-xylose, the esters thereof and oligosaccharides containing xylose for improving the functionality of epidermal cells

Applicant/Assignee: LVMH RECHERCHE

Application No.: 09/529423   Filing Date: 02/May/2000

Abstract:

A method for stimulating the synthesis and/or secretion of proteoglycans and/or glycosaminoglycans by keratinocytes of a human in need thereof, by applying to an external body area of the human a composition containing an effective amount of D-xylose, an ester thereof or an oligosaccharide containing D-xylose, in a combination with a cosmetically or pharmaceutically acceptable excipient.

Priority: FR19970014023 Applic. Date: 1997-11-07; WO1998FR02382 Applic. Date: 1998-11-06

Inventor: DUMAS MARC [FR]; BONTE FREDERIC [FR]


Patent No.: US6495150B2  Issued: 17/Dec/2002

Title: Topical composition comprising a functionalized acid anhydride-based cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/091809   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functionalized acid anhydride-based bonding agent having the structurewherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273986P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6495588B2  Issued: 17/Dec/2002

Title: Scytonemin and methods of using thereof

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA STATE OF OREGON C/O OREGON STATE UNIVERSITY GLAXOSMITHKLINE

Application No.: 09/960314   Filing Date: 24/Sep/2001

Abstract:

Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

Priority: US2001-790640 Applic. Date: 2001-02-23; US20000185029P Applic. Date: 2000-02-25

Inventor: JACOBS ROBERT S [US]; MARSHALL LISA A [US]; GERWICK WILLIAM H [US]; STEVENSON CHRISTOPHER [US]


Patent No.: US6497887B1  Issued: 24/Dec/2002

Title: Membrane delivery system

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 09/549113   Filing Date: 13/Apr/2000

Abstract:

The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent. The membrane can be used to deliver biologically active agents to the skin.

Priority:

Inventor: ZECCHINO JULES [US]; KNIGHT E ALTHEA [US]; CASTILLO-BUCCI CARMEN [US]


Patent No.: US6497888B1  Issued: 24/Dec/2002

Title: Process for limiting the penetration into the skin and/or the keratinous fibres of an active cosmetic and/or pharmaceutical agent

Applicant/Assignee: L'OREAL S.A

Application No.: 09/689636   Filing Date: 13/Oct/2000

Abstract:

A process, composition, and kit for limiting the penetration into the skin and/or the keratinous fibers of at least one cosmetically and/or pharmaceutically active agent present in a base cosmetic and/or pharmaceutical composition for topical application and in particular for reducing the rate of penetration into the skin and/or the keratinous fibers of the active agent(s). The process includes the joint use, with the base composition, of an effective amount of a dispersion of vesicles in a medium, the vesicles comprising at least one ceramide of formula (I):wherein R1 is chosen from saturated and unsaturated, linear and branched C1-C32 alkyl groups optionally substituted by at least one hydroxyl group, wherein said at least one hydroxyl group is optionally esterified by a group chosen from C1-C35 acyls

and R2 is chosen from saturated and unsaturated, linear and branched C1-C50 alkyl groups optionally substituted by at least one hydroxyl groups, and wherein said at least one hydroxyl group is optionally esterified by a group chosen from C1-C30 acyls.

Priority: FR19990012832 Applic. Date: 1999-10-14

Inventor: MORANCAIS JEAN-LUC [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6497893B1  Issued: 24/Dec/2002

Title: Silk protein treatment composition and treated substrate for transfer to skin

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 09/343861   Filing Date: 30/Jun/1999

Abstract:

The present invention relates to a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a silk protein on skin by an aqueous emulsion mediated dissolution of protein from a substrate with subsequent transfer and deposition onto the skin. Coatings of silk protein on skin resist removal, thereby providing a protective barrier against chemically- and biochemically-induced skin damage. The treatment composition also provides a vehicle for administering an effective dose of an active agent to the skin surface.

Priority:

Inventor: EVERHART DENNIS STEIN [US]; DI LUCCIO ROBERT COSMO [US]; YAHIAOUI ALI [US]; MAY WADE BOLTON [US]; TYRRELL DAVID JOHN [US]; GADSBY ELIZABETH DEIBLER [US]; GILLBERG-LAFORCE GUNILLA ELSA [US]


Patent No.: US6500411B2  Issued: 31/Dec/2002

Title: Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same

Applicant/Assignee: AMCOL INTERNATIONAL CORPORATION

Application No.: 10/068268   Filing Date: 05/Feb/2002

Abstract:

Cosmetic and personal care compositions can be manufactured using the multifunctional-additive compositions of the present invention. Such an additive preferably contains one or more particulate-based thickeners, such as a smectite clay, colloidal silica, laponite, and/or alumina, and most preferably one. or more smectite clays. According to one important embodiment of the present invention, the thickener particles are co-dispersed with particles of one or more particulate UVR-filters such as titanium dioxide, zinc oxide, or SUNSPHERE (available from International Specialty Chemicals, ISP), and most preferably with the natural particulate sunscreens such as the metal oxides.

Another important component of the multifunctional-additive compositions is a dispersant or surface-modifier for the foregoing particulate materials, selected from the family of polyphenolic, natural polymers such as lignosulfonates, lignins, humates, tannates, and derivatives thereof. In addition, these compositions optionally include one or more of the following components: electrolytes, defoamers, humectants, emollients for cosmetics, preservatives, whiteners, and the like.

Priority: US20010266596P Applic. Date: 2001-02-05; US20010318979P Applic. Date: 2001-09-13

Inventor: SENGUPTA ASHOKE K [US]; SPINDLER RALPH [US]; DARLINGTON JR JERALD W [US]


Patent No.: US6500443B1  Issued: 31/Dec/2002

Title: Delivery of a sacrificial substrate to inhibit protease permeation into skin

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 09/578761   Filing Date: 25/May/2000

Abstract:

The present invention relates to a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a sacrificial substrate on skin by an aqueous emulsion mediated dissolution of protein from a sheet material with subsequent transfer and deposition onto the skin. Coatings of sacrificial substrate on skin resist removal, thereby providing a protective barrier against chemically- and biochemically-induced skin damage. The treatment composition also provides a vehicle for administering an effective dose of an active agent to the skin surface.

Priority: US19990141909P Applic. Date: 1999-06-30

Inventor: OTTS DAVID ROLAND [US]; TYRRELL DAVID JOHN [US]; HUARD LINDA SUSAN [US]; AKIN FRANK JERREL [US]; DI LUCCIO ROBERT COSMO [US]


Patent No.: US6500446B1  Issued: 31/Dec/2002

Title: Compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nonopartculate vector, and their use for treating living or inert surfaces

Applicant/Assignee: VIRBAC

Application No.: 09/059200   Filing Date: 14/Apr/1998

Abstract:

The present invention relates to compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nanoparticulate vector, and their use for treating living or inert surfaces.

Priority: FR19970004549 Applic. Date: 1997-04-14

Inventor: DERRIEU GUY [FR]; POUGNAS JEAN-LUC [FR]; MONGINOUX PATRICIA [FR]; KARST CHRISTIAN [FR]


Patent No.: US6500798B1  Issued: 31/Dec/2002

Title: Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 09/641803   Filing Date: 17/Aug/2000

Abstract:

The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress regulator.

Priority: US19990149310P Applic. Date: 1999-08-17

Inventor: STANTON G JOHN [US]; HUGHES JR THOMAS K [US]; BOLDOGH ISTVAN [US]


Patent No.: US6500857B1  Issued: 31/Dec/2002

Title: Subcutaneous muscle treatment using electronic stimulation and topical compositions

Applicant/Assignee:

Application No.: 09/931616   Filing Date: 16/Aug/2001

Abstract:

Aging and sagging subcutaneous muscles are treated by first applying a composition containing at least one acetylcholine precursor and/or at least one compound exhibiting catecholamine activity to the overlying skin area, and then electronically stimulating the overlying skin area using electrical pulses in amounts sufficient to cause the subcutaneous muscles to contract. Preferred compositions contain from about 1% to about 10%, more narrowly from about 0.25% to about 5% by weight of an alkanolamine such as dimethylaminoethanol, the calcium salt of 2-aminoethanol phosphate or mixtures thereof and about from about 1% to about 10%, more narrowly from about 1% to 5% by weight of a compound exhibiting catecholamine activity such as tyrosine. Preferred electronic muscle stimulating devices deliver electrical pulses via electrodes in the fingertips of a compact device that fits on the hand.

Priority:

Inventor: PERRICONE NICHOLAS V [US]


Patent No.: US6503492B2  Issued: 07/Jan/2003

Title: ANTIPERSPIRANT OR DEODORANT COMPOSITIONS

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA, A DIVISION OF CONOPCO, INC

Application No.: 10/079083   Filing Date: 19/Feb/2002

Abstract:

Deodorant and antiperspirant compositions comprising an aluminium or aluminium-zirconium active can suffer from perceived irritancy when applied topically, which is generally manifested as an itch sensation. This irritancy can be ameliorated or overcome by incorporating within the composition a cannabanoid receptor (CBR) activating agent, and especially an amount selected in the range of from 0.25 to 10 wt %.

Priority: GB20010004268 Applic. Date: 2001-02-21

Inventor: MCGLONE FRANCIS [GB]; PATERSON SARAH [GB]; RAWLINGS ANTHONY VINCENT [GB]; RUKWIED ROMAN [GB]; WATKINSON ALLAN [GB]


Patent No.: US6503516B1  Issued: 07/Jan/2003

Title: Make-up composition containing a blend of waxes

Applicant/Assignee: L'OREAL S.A

Application No.: 09/434130   Filing Date: 05/Nov/1999

Abstract:

A composition which can be molded in the form of a stick or hot-poured, comprisingat least one wax having a melting point of greater than 95 DEG C. and a penetration of from 1 to 7.5 mm, andat least one organically modified beeswax having a penetration of greater than 7.5 mm,wherein the waxes are present in a combined amount sufficient to provide stability and a creamy texture to a molded stick or to a product resulting from hot-pouring, and a process for caring for and/or making-up the eyes, lips, or skin using this composition.

Priority: US19980107345P Applic. Date: 1998-11-06

Inventor: VAN LIEW TERRY [US]; ALONZO OLGA [US]; SMITH MICHAEL [US]


Patent No.: US6503520B1  Issued: 07/Jan/2003

Title: Water-in-oil emulsion containing fibers and the use thereof as a cosmetic composition

Applicant/Assignee: L'OREAL

Application No.: 09/689768   Filing Date: 13/Oct/2000

Abstract:

A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and-at least one wax.The composition obtained has very good stability and can in particular constitute a cosmetic composition.The invention also relates to the use of the said composition, in particular for caring for, treating, making up or cleansing the skin the lips, the eyelashes and/or the hair.

Priority: FR19990012911 Applic. Date: 1999-10-15

Inventor: AFRIAT ISABELLE [FR]


Patent No.: US6503522B2  Issued: 07/Jan/2003

Title: Tertiary amide-terminated polyamides in structured personal care compositions

Applicant/Assignee: ARIZONA CHEMICAL COMPANY

Application No.: 09/893317   Filing Date: 27/Jun/2001

Abstract:

A structured, solid composition that contains at least one colorant, a liquid oil phase, and a gellant, wherein the gellant is a tertiary amide-terminated polyamide resin (ATPA) of the formula (1):wherein, n designates a number of repeating units such that terminal amide groups constitute from 10% to 50% of the total amide groups

R1 at each occurrence is independently selected from a C1-22 hydrocarbon group

R2 at each occurrence is independently selected from a C2-42 hydrocarbon group

R3 at each occurrence is independently selected from an organic group containing at least two carbon atoms in addition to hydrogen atoms, and optionally containing one or more oxygen and nitrogen atoms

and R3a at each occurrence is independently selected from hydrogen, C1-10 alkyl and a direct bond to R3 or another R3a such that the N atom to which R3 and R3a are both bonded is part of a heterocyclic structure defined in part by R3a-N-R3, the composition being in the form of a solid

the liquid oil phase and the ATPA resin forming a physiologically acceptable medium. The composition may be formulated into a cosmetic or other personal care product, for instance, a black mascara, eye liner, foundation, lipstick, blush, deodorant or make-up remover, body make-up, eye shadow or rouge, or concealer.

Priority: US1999-225889 Applic. Date: 1999-01-04

Inventor: LAWSON NELSON E [US]; PAVLIN MARK S [US]


Patent No.: US6503531B2  Issued: 07/Jan/2003

Title: Antimicrobial containing solventless hot melt adhesive composition

Applicant/Assignee: MEDICAL CONCEPTS DEVELOPMENT, INC

Application No.: 09/836764   Filing Date: 17/Apr/2001

Abstract:

An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The adhesive composition is essentially solventless and capable of application in a hot melt process while maintaining stability at elevated temperatures in the range of 275 DEG F. to 350 DEG F., which not only allows hot melt application, but allows for ethylene oxide sterilization under heat stress.

Priority: US1998-185456 Applic. Date: 1998-11-03; US1996-662850 Applic. Date: 1996-06-12

Inventor: COX DAVID D [US]; LUND ROBERT E [US]; ANNETT LELAND W [US]


Patent No.: US6503539B2  Issued: 07/Jan/2003

Title: MATRIX PROTEIN COMPOSITIONS FOR WOUND HEALING

Applicant/Assignee: BIORA BIOEX AB

Application No.: 09/258613   Filing Date: 26/Feb/1999

Abstract:

Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.

Priority: DK19980000270 Applic. Date: 1998-02-27; DK19980001328 Applic. Date: 1998-10-16; US19980081551P Applic. Date: 1998-04-13

Inventor: GESTRELIUS STINA [SE]; HAMMARSTROEM LARS [SE]; LYNGSTADAAS PETTER [NO]; ANDERSSON CHRISTER [SE]; SLABY IVAN [SE]; HAMMARGREN TOMAS [SE]


Patent No.: US6503894B1  Issued: 07/Jan/2003

Title: Pharmaceutical composition and method for treating hypogonadism

Applicant/Assignee: UNIMED PHARMACEUTICALS, INC LABORATORIES BESINS ISCOVESCO

Application No.: 09/651777   Filing Date: 30/Aug/2000

Abstract:

A pharmaceutical composition useful for treating hypogonadism is disclosed. The composition comprises an androgenic or anabolic steroid, a C1-C4 alcohol, a penetration enhancer such as isopropyl myristate, and water. Also disclosed is a method for treating hypogonadism utilizing the composition.

Priority:

Inventor: DUDLEY ROBERT E [US]; DROUIN DOMINIQUE [US]


Patent No.: US6506369B2  Issued: 14/Jan/2003

Title: TOPICAL PRODUCT WITH VISUAL INDICATOR

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 09/859073   Filing Date: 16/May/2001

Abstract:

A product for application to the skin includes a container and a composition within the container including a cosmetic or therapeutic active ingredient. Sometime after first use, the application surface of the composition changes from a first visual appearance to a second visual appearance due to a change in the composition.

Priority:

Inventor: AMBLER PHILIP WILLIAM [GB]; HOLE PHILIP NORMAN [GB]; MOLONEY MICHAEL J [US]; GALANTE CHERYL L [US]; GERSTEN IRIS DAVIS [US]; SOLAN JAMES L [US]; VAN DER LEE HERMES [US]


Patent No.: US6506391B1  Issued: 14/Jan/2003

Title: Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueous phase, stabilized with cubic gel particles

Applicant/Assignee: L'OREAL

Application No.: 09/347101   Filing Date: 02/Jul/1999

Abstract:

W/O or O/W stable dispersions are formed by mixing an oily phase and an aqueous phase when the dispersion is stabilized with cubic gel particles formed by the combination of two amphiphilic compounds, one of the amphiphilic compounds being capable of forming a lamellar phase in the presence of water, and the other being capable of forming an inverse hexagonal phase in the presence of water.

Priority: FR19980008559 Applic. Date: 1998-07-03

Inventor: BIATRY BRUNO [FR]


Patent No.: US6506421B2  Issued: 14/Jan/2003

Title: Process for the extraction of an active principle from teguments of apple, active principle obtained, and composition for counteracting the consequences of oxidative stress of the skin

Applicant/Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE (SILAB)

Application No.: 09/848265   Filing Date: 04/May/2001

Abstract:

The present invention is a process for the extraction of an active principle for action against the consequences of oxidative stress, permitting countering cutaneous aging, characterized in that it comprises the following steps:reduction to fine powder of dried apple tegument,solubilization of this powder with at least 8% by volume of powder in an aqueous solution,conjoint enzymatic hydrolysis of the sugars and proteins,heating permitting total inactivation of the enzymes, andsterilizing filtration to retain the microorganisms, yeasts and molds as well as the total mesophilic flora.The invention also covers the associated compositions and a process for countering accelerated aging of the skin.

Priority: FR20000005726 Applic. Date: 2000-05-04

Inventor: PAUFIQUE JEAN-JACQUES [FR]


Patent No.: US6506495B1  Issued: 14/Jan/2003

Title: Complex skin, slush molding thermoplastic elastomer composition for use in the skin, and an article including the skin

Applicant/Assignee: MITSUBOSHI BELTING LTD

Application No.: 09/290796   Filing Date: 13/Apr/1999

Abstract:

A multilayer skin comprising an outer layer prepared by slush molding powder of a thermoplastic elastomer composition having a polypropylene resin, a hydrogenated styrene-butadiene random copolymer rubber, a process oil, an elastomer with high oil absorption capability, and a release agent. An inner layer is bonded to the outer layer, is prepared by slush molding, and is a blend of an elastomer with high oil absorption capability, an olefinic polymer with active hydrogen, and a catalyst which promotes isocyanate reaction. There is also a multilayer skin with a different composition as well as an article made with a multilayer skin having the compositions. There is further a thermoplastic elastomer composition for a layer of a multilayer skin.

Priority: JP19980100787 Applic. Date: 1998-04-13; JP19980102402 Applic. Date: 1998-04-14; JP19980216632 Applic. Date: 1998-07-31

Inventor: ENAMI HIROHIDE [JP]; ONO KENROU [JP]; KUBOMOTO KENJI [JP]; OKAZAWA TAKAHIDE [JP]


Patent No.: US6506572B2  Issued: 14/Jan/2003

Title: Inhibitors of cellular niacinamide mononucleotide formation and their use in cancer therapy

Applicant/Assignee: KLINGE PHARMA GMBH

Application No.: 09/935772   Filing Date: 23/Aug/2001

Abstract:

New biologically active compounds are described which inhibit the cellular formation of niacinamide mononucleotide, and essential intermediate of the NAD(P) biosynthesis in the cell. These compounds can represent the active ingredient of a pharmaceutical composition for the treatment of cancers, leukaemias or for immunosuppression. Furthermore, screening methods are described as a tool for detecting the above active compounds, and for examination of a given cell type for its dependency on niacinamide as a precursor for NAD synthesis.

Priority: EP19990103814 Applic. Date: 1999-02-26; WO2000EP01628 Applic. Date: 2000-02-28

Inventor: BIEDERMANN ELFI [DE]; EISENBURGER ROLF [DE]; HASMANN MAX [DE]; LOESER ROLAND [DE]; RATTEL BENNO [DE]; REITER FRIEDEMANN [DE]; SCHEIN BARBARA [DE]; SCHEMAINDA ISABEL [DE]; SCHULZ MICHAEL [DE]; SEIBEL KLAUS [DE]; VOGT KLAUS [DE]; WOSIKOWSKI KATJA [DE]


Patent No.: US6506713B1  Issued: 14/Jan/2003

Title: Cosmetic effervescent cleansing compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/635377   Filing Date: 09/Aug/2000

Abstract:

A cosmetic cleansing article is provided which includes an effervescent cleanser composition held within a sachet having at least one water permeable wall. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. The powdered mixture of alkaline/acid materials is storage stabilized against premature effervescent action by dispersing therewithin plant solids.

Priority: US20000179235P Applic. Date: 2000-01-31

Inventor: SLAVTCHEFF CRAIG STEPHEN [US]; GOTT ROBERT EDWARD [US]; ZNAIDEN ALEXANDER PAUL [US]


Patent No.: US6506731B1  Issued: 14/Jan/2003

Title: Elastin peptide analogs and methods of using same

Applicant/Assignee: CONNECTIVE TISSUE IMAGINEERING LLC

Application No.: 09/584001   Filing Date: 30/May/2000

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin More preferably, the present invention corresponds to the general formula R1-Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine-R2.

Priority: US1998-039308 Applic. Date: 1998-03-13; WO1999US05496 Applic. Date: 1999-03-12

Inventor: SANDBERG LAWRENCE B [US]; MITTS THOMAS F [US]


Patent No.: US6506750B1  Issued: 14/Jan/2003

Title: Morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives

Applicant/Assignee: SANOFI-SYNTHELABO

Application No.: 09/937279   Filing Date: 24/Sep/2001

Abstract:

N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle.

Priority: FR19990003854 Applic. Date: 1999-03-25; WO2000FR00695 Applic. Date: 2000-03-21

Inventor: DUCOUX JEAN-PHILIPPE [FR]; EMONDS-ALT XAVIER [FR]; GUEULE PATRICK [FR]; PROIETTO VINCENZO [IT]


Patent No.: US6506796B1  Issued: 14/Jan/2003

Title: Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis

Applicant/Assignee: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA

Application No.: 09/624771   Filing Date: 25/Jul/2000

Abstract:

Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthanoic acid.

Priority: FR19950012179 Applic. Date: 1995-10-09

Inventor: FESUS LASZLO [HU]; SZONDY ZSUZSA [HU]; REICHERT UWE [FR]


Patent No.: US6509008B1  Issued: 21/Jan/2003

Title: Solubilization of 1,3,5-triazine derivatives with N-acyl amino acid esters

Applicant/Assignee: L'OREAL

Application No.: 10/178339   Filing Date: 25/Jun/2002

Abstract:

A composition comprising at least one 1,3,5-triazine derivative and at least one N-acyl amino acid ester and its use in or for the manufacture of compositions, especially cosmetic and dermatological compositions for protecting the skin and/or the lips and/or integuments against ultraviolet radiation, in particular solar radiation. In addition, a cosmetic treatment process comprising the application of the cosmetic composition, and the use of the at least one N-acyl amino acid ester, in anti-sun compositions containing a 1,3,5-triazine derivative to improve the sun protection factor of the composition.

Priority: FR20010008426 Applic. Date: 2001-06-26

Inventor: CANDAU DIDIER [FR]


Patent No.: US6509010B2  Issued: 21/Jan/2003

Title: Cosmetic products for the reduction of sweat acidity

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/066183   Filing Date: 31/Jan/2002

Abstract:

A cosmetic method of reducing the acidity of sweat excreted from human eccrine glands, said method comprising the topical application of a V-ATPase inhibitor to the skin in the vicinity of the eccrine glands. Said method may result in a range of benefits, including enhanced appreciation of topically-applied perfume and enhanced efficacy of topically-applied antiperspirant salt. Cosmetic products and compositions comprising a V-ATPase inhibitor and selected other components are also claimed.

Priority: GB20010002562 Applic. Date: 2001-02-01

Inventor: BECK JONATHAN SAMUEL [GB]; BURRY JASON SHAUN [GB]; EVANS RICHARD LIVESEY [GB]; GRANGER DOMINIC [CA]; LAPRADE RAYNALD [CA]; MARSOLAIS MIREILLE [CA]


Patent No.: US6509024B2  Issued: 21/Jan/2003

Title: Composition in the form of water-in-oil emulsion and its cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/813032   Filing Date: 21/Mar/2001

Abstract:

The first embodiment of the present invention provides a composition, which includes:an aqueous phase dispersed in an oily phase

wherein the oily phase includes at least one particle of a crosslinked solid organopolysiloxane elastomer having at least one oxyalkylene group,and wherein the aqueous phase includes at least one crosslinked and at least partially neutralized poly(2-acrylamido-2-methylpropanesulphonic acid) polymer. Other embodiments of the present invention provide methods of using the above-identified composition, compositions containing same, and a method of preparing water-in-oil emulsions.

Priority: FR20000003589 Applic. Date: 2000-03-21

Inventor: LORANT RALUCA [FR]


Patent No.: US6509031B1  Issued: 21/Jan/2003

Title: System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix

Applicant/Assignee: BOARD OF REGENTS, TEXAS A&M UNIVERSITY SYSTEM

Application No.: 09/713270   Filing Date: 15/Nov/2000

Abstract:

This invention relates to materials and methods for crosslinking, in situ, proteins, including collagen, with peroxidase, including horseradish peroxidase, to from biocompatible semi-solid gels useful in a number of biological and food product applications.

Priority: US19990165567P Applic. Date: 1999-11-15; US19990166024P Applic. Date: 1999-11-17

Inventor: MILLER DOUGLAS R [US]; TIZARD IAN R [US]; KEETON JIMMY T [US]; PROCHASKA JERRY F [US]


Patent No.: US6509042B1  Issued: 21/Jan/2003

Title: Anti viral composition

Applicant/Assignee: HADAS NATURAL PRODUCTS LTD

Application No.: 09/695853   Filing Date: 26/Oct/2000

Abstract:

Disclosed is a pharmaceutical composition., especially for treating herpes and condyloma, comprising an extraction product of broad beans, as an active ingredient.

Priority: IL19990132665 Applic. Date: 1999-10-31

Inventor: KOREN ODELIA [IL]; AVRAHAMI SIMA [IL]; BYMEL HADASSA [IL]


Patent No.: US6511659B2  Issued: 28/Jan/2003

Title: Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/874053   Filing Date: 06/Jun/2001

Abstract:

Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I):in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical -OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.

Priority: FR19980009509 Applic. Date: 1998-07-24; US1999-360495 Applic. Date: 1999-07-23

Inventor: MAHE YANN [FR]; MICHELET JEAN-FRANCOIS [FR]; PICHAUD PATRICK [FR]; GALEY JEAN-BAPTISTE [FR]


Patent No.: US6511684B1  Issued: 28/Jan/2003

Title: Use of plant extracts with an anti-radical-type action

Applicant/Assignee: COGNIS FRANCE (SOCIETE ANONYME)

Application No.: 09/857445   Filing Date: 04/Jun/2001

Abstract:

The use of plant extracts, especially plant extracts with an anti-radical-type action, and a cosmetic or dermo-pharmaceutical composition containing extracts of this type. The use of at least one plant extract whose botanical genus belongs to the group formed by the following: Clidemia, Inga, Sabicea, Astrocaryum, Siparuna, Eperua, Byrsonima, Priva, Coutoubea and Goupia genera

as an active substance which has especially anti-radical-type activities, for preparing a cosmetic or dermopharmaceutical product for local, external use for the skin, the mucous membranes and/or the epithel or appendage structures.

Priority: WO1999EP09294 Applic. Date: 1999-11-30; FR19980015380 Applic. Date: 1998-12-03

Inventor: PAULY GILLES [FR]; MORETTI CHRISTIAN [FR]


Patent No.: US6512072B1  Issued: 28/Jan/2003

Title: Fast cure film forming formulation

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 09/591847   Filing Date: 12/Jun/2000

Abstract:

A formulation for depositing a film on a substrate comprising 5 to79.9 wt. % of an alkylene trialkoxy terminated polysiloxane

0.01 to 5 wt. % of a catalyst

20 to 94.99 to wt % of a volatile diluent, and, optionally, 0.01 to 5 wt. % of an alkoxysilane and 0.1 to 25 wt % of a filler. The formulations are especially valuable for forming films to be used in personal care or healthcare applications.

Priority:

Inventor: GANTNER DAVID CLAYTON [US]; LACHANCE KEITH ALAN [US]; MAXON BARTLEY DEAN [US]; ULMAN KATHERINE LYNN [US]; ZELLNER DEBRA JO NAGY [US]


Patent No.: US6512950B2  Issued: 28/Jan/2003

Title: Methods for delivering agents using alternating current

Applicant/Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Application No.: 09/783138   Filing Date: 13/Feb/2001

Abstract:

A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which transport occurs, thereby allowing agent to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be included to assist in promoting transfer of the agent. The methods have utility in a variety of different clinical settings and applications.

Priority: US20000184119P Applic. Date: 2000-02-18; US20000244116P Applic. Date: 2000-10-28

Inventor: LI S KEVIN [US]; HIGUCHI WILLIAM I [US]; ZHU HONGGANG [US]; SONG YANG [US]


Patent No.: US6514485B1  Issued: 04/Feb/2003

Title: Combinations of sunscreens

Applicant/Assignee: 3V SIGMA S.P.A

Application No.: 09/475018   Filing Date: 30/Dec/1999

Abstract:

Combinations of sunscreens comprising at least one specific anti uv-B filter with triazinoaniline structure and at least one specific anti UV-A filter selected from filters with benzoxazol substituted triazinoaniline structure and a long chain alkyl ester of a benzoxazolyl-aminophenyl-cyanoacrylic acid. Cosmetic and dermatological compositions containing them, optionally in combination with vitamins and/or other anti UV-A and anti UV-B filters.

Priority: IT1999BG00001 Applic. Date: 1999-01-11

Inventor: MALPEDE ALVERIO [IT]; ZANCHI GIORGIO [IT]


Patent No.: US6514486B1  Issued: 04/Feb/2003

Title: Composition for topical application comprising at least one iminophenol compound

Applicant/Assignee: L'OREAL

Application No.: 09/341099   Filing Date: 10/Sep/1999

Abstract:

The invention relates to a composition for topical application to the skin and/or its superficial growths comprising, in a cosmetically and/or dermatologically acceptable medium, at least one compound comprising an iminophenol fragment and to the use of the said compound in a composition as agent for depigmenting and/or lightening the human skin, the body hairs and/or the hair.It also relates to a process for depigmenting and/or lightening the skin, the body hairs and/or the hair which consists in applying the abovementioned composition to the human skin, the body hairs and/or the hair.

Priority: FR19970013843 Applic. Date: 1997-11-04; WO1998FR02284 Applic. Date: 1998-10-26

Inventor: TULOUP REMY [FR]; BLAISE CHRISTIAN [FR]


Patent No.: US6514507B2  Issued: 04/Feb/2003

Title: Hydroxydecenoic acid compounds for promoting desquamation/epidermal renewal of the skin and/or combating skin aging

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/996904   Filing Date: 30/Nov/2001

Abstract:

10-Hydroxy-2-decenoic acid and derivatives thereof are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a candidate individual in need of such treatment, by administering thereto, for such period of time as required to elicit the desired response, an effective amount of at least one of said 10-hydroxy-2-decenoic acid or derivative thereof.

Priority: FR19980011811 Applic. Date: 1998-09-22; US1999-399181 Applic. Date: 1999-09-20

Inventor: MAIGNAN JEAN [FR]; GENARD SYLVIE [FR]


Patent No.: US6514515B1  Issued: 04/Feb/2003

Title: Bioabsorbable, biocompatible polymers for tissue engineering

Applicant/Assignee: TEPHA, INC

Application No.: 09/518123   Filing Date: 03/Mar/2000

Abstract:

Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or tensile modulus (Young's modulus) values of the tissues of the cardiovascular, gastrointestinal, kidney and genitourinary, musculoskeletal, and nervous systems, as well as those of the oral, dental, periodontal, and skin tissues. Methods for processing the bioabsorbable biocompatible polymers into tissue engineering devices are also provided.

Priority: US19990122827P Applic. Date: 1999-03-04

Inventor: WILLIAMS SIMON F [US]


Patent No.: US6514734B1  Issued: 04/Feb/2003

Title: Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups

Applicant/Assignee: SURMODICS, INC

Application No.: 09/591564   Filing Date: 09/Jun/2000

Abstract:

A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.

Priority: US1997-916913 Applic. Date: 1997-08-15

Inventor: CLAPPER DAVID L [US]; SWANSON MELVIN J [US]; HU SHEAU-PING [US]; AMOS RICHARD A [US]; EVERSON TERRENCE P [US]


Patent No.: US6517816B1  Issued: 11/Feb/2003

Title: Sunscreen emulsion composition and method of use

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 10/032847   Filing Date: 26/Dec/2001

Abstract:

There is provided a sunscreen emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has a sunscreen active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from overexposure to the sun in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a sunscreen emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free sunscreen composition.

Priority:

Inventor: GONZALEZ ANTHONY D [US]; PECHKO ANDREW H [US]; WANG HELEN [US]


Patent No.: US6517819B1  Issued: 11/Feb/2003

Title: Antiperspirant suspensions containing finely divided aluminium and zirconium, having better effectiveness and a process for their manufacture

Applicant/Assignee: BK GIULINI CHEMIE GMBH UND CO OHG

Application No.: 09/579506   Filing Date: 26/May/2000

Abstract:

An antiperspirant suspension which is finely divided, which is contained in a non-aqueous phase, and which has improved efficacy for perspiration reduction when used on human skin, includes at least one basic aluminum-zirconium-halogenohydrate complex as active ingredient in which at least 60% of the zirconium content can be directly titrated after dissolving in 0.1 n HCl with EDTA at a pH of 0.8, wherein the active ingredient optionally contains an amino acid. A process for the synthesis of the antiperspirant suspension includes mixing an aluminum salt which is effective as an antiperspirant with a zirconium salt which is effective as an antiperspirant, optionally in the presence of an amino acid, in a non-aqueous oil phase in the absence of water to provide a mixture

and grinding the mixture.

Priority: EP19990110455 Applic. Date: 1999-05-29

Inventor: BREKER JOHANNES [DE]; KAUFMANN BRUNO [DE]; REIBEL WOLFGANG [DE]; SCHANZ KLAUS [DE]


Patent No.: US6517847B2  Issued: 11/Feb/2003

Title: Topical gel delivery system

Applicant/Assignee: DOW PHARMACEUTICAL SCIENCES

Application No.: 10/096516   Filing Date: 08/Mar/2002

Abstract:

A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition is a lotion that consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) a pharmaceutically acceptable base to adjust pH, (d) up to about 25% ww of at least one water miscible solvent, (e) optionally a preservative, (f) water, and (g) an oil phase component and suitable surfactant. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea.

Priority: US2000-632508 Applic. Date: 2000-08-03

Inventor: DOW GORDON J [US]; LATHROP ROBERT W [US]; DOW DEBRA A [US]


Patent No.: US6520950B1  Issued: 18/Feb/2003

Title: Method of electroporation-enhanced delivery of active agents

Applicant/Assignee: GENETRONICS, INC

Application No.: 09/567404   Filing Date: 08/May/2000

Abstract:

Methods are provided for introducing a biologically active agent into cells of a subject by injecting the agent with a needle-free injector and applying a pulsed electric field to the region of tissue to cause electrotransport of the agent into cells of the tissue. Preferably the agent is either ionized to some degree or contained in an ionized medium for electrotransport. The needle-free injector can serve as an electrode by which the pulsed electric field is applied to the region of tissue. The active agents delivered into cells by this method include small molecules, polynucleotides, polypeptides, and the like. Polynucleotides introduced into cells using this method can be used to accomplish gene therapy or to modulate expression of an endogenous gene.

Priority: US19990133265P Applic. Date: 1999-05-10

Inventor: HOFMANN GUNTER A [US]; RABUSSAY DIETMAR P [US]; ZHANG LEI [US]


Patent No.: US6521222B1  Issued: 18/Feb/2003

Title: Inorganic/organic complexes for reducing skin irritation

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/671627   Filing Date: 28/Sep/2000

Abstract:

beta-Diketone/hydroxylated or carbonated activated cation inorganic/organic complexes are well suited for reducing skin irritation, notably that elicited by exposure to irritant active agents/species or to the external environment.

Priority: FR19990012057 Applic. Date: 1999-09-28

Inventor: PHILIPPE MICHEL [FR]; COHEN CATHERINE [FR]


Patent No.: US6521606B2  Issued: 18/Feb/2003

Title: Matrix metalloproteinase inhibitors

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS, LTD. A/S

Application No.: 09/899017   Filing Date: 06/Jul/2001

Abstract:

A compound of the general formula Iwherein Y is O or S

n is 1, 2, 3 or 4

X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group

R1 iswherein E, when present represents, a bond or optionally substituted methylene or ethylene

s and t are independently 0, 1, 2 or 3

A and A' independently represent a bond, or a saturated or unsaturated, optionally substituted cyclic or heterocyclic hydrocarbon di- or triradical

Z represents a bond, O, S, C(O), C(O)NR7, NR7C(O) or NR7, wherein R7 is hydrogen, hydroxy, branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical

R5 represents a bond, alkane or alkene diradical, one or more ether diradicals (R-O-R') or amine diradicals (R-N-R'), wherein R and R' independently represent alkane or alkene diradicals with a C-content from 0 to 3

R6 represents hydrogen, hydroxy, halogen, cyano, nitro, branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical, unsaturated optionally substituted cyclic or heterocyclic hydrocarbon radical, NR8R9, C(O)NR8R9, C(O)R8, CO(O)R8, S(O)2R9, wherein each R8 and R9 independently represent hydrogen, halogen, a branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical

R2 represents hydrogen, (C1-8)alkyl, (C2-6)alkenyl, (C3-8)cycloalkyl, aryl(C0-6)alkyl or heteroaryl(C0-6)alkyl

provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen

or a salt, hydrate or solvate thereof.The compounds are valuable for human and veterinary therapy.

Priority: US20000219031P Applic. Date: 2000-07-18

Inventor: SOERENSEN MORTEN DAHL [DK]; BLAEHR LARS KRISTIAN ALBERT [DK]; CHRISTENSEN METTE KNAK [DK]


Patent No.: US6524564B1  Issued: 25/Feb/2003

Title: Urethane(meth)acrylates containing siloxane groups and able to undergo free-radical polymerization

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 09/762929   Filing Date: 14/Feb/2001

Abstract:

The present invention relates to free-radically polymerizable, siloxane-containing urethane (meth)acrylates which comprise, in incorporated form,a) at least one compound which contains at least one active hydrogen atom and at least one free-radically polymerizable alpha,beta-ethylenically unsaturated double bond per molecule,b) at least one diisocyanate,c) at least one compound which contains two active hydrogen atoms per molecules,d) at least one compound which contains at least one active hydrogen atom and at least one siloxane group per molecule,to water-soluble or water-dispersible polymers which comprise these urethane (meth)acrylates in copolymerized form, to the use of these polymers, and to cosmetic compositions which comprise these polymers.

Priority: DE19981038852 Applic. Date: 1998-08-26; DE19991023276 Applic. Date: 1999-05-20; WO1999EP06234 Applic. Date: 1999-08-25

Inventor: KIM SON NGUYEN [DE]; SANNER AXEL [DE]; SCHEHLMANN VOLKER [DE]


Patent No.: US6524593B1  Issued: 25/Feb/2003

Title: N-acetyl aldosamines and related N-acetyl compounds, and their topical use

Applicant/Assignee:

Application No.: 09/560901   Filing Date: 28/Apr/2000

Abstract:

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Priority: US1999-227213 Applic. Date: 1999-01-08

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE [US]


Patent No.: US6524595B1  Issued: 25/Feb/2003

Title: Cyclodextrins preferentially substituted on their primary face by acid or amine functions

Applicant/Assignee: COLETICA

Application No.: 09/613773   Filing Date: 11/Jul/2000

Abstract:

Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the -OH portion being replaced by a substituent with formula -O-CO-R or -NR1R2, where:R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

Priority: FR20000006102 Applic. Date: 2000-05-12

Inventor: PERRIER ERIC [FR]; TERRY NICOLAS [FR]; RIVAL DELPHINE [FR]; COLEMAN ANTHONY WILLIAM [FR]


Patent No.: US6524598B2  Issued: 25/Feb/2003

Title: Cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/850763   Filing Date: 08/May/2001

Abstract:

The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.

Priority: US20000217114P Applic. Date: 2000-07-10

Inventor: SUNKEL JORGE MAX [US]; VATTER MICHAEL LEE [US]


Patent No.: US6524623B1  Issued: 25/Feb/2003

Title: Therapeutic compositions and methods of use thereof

Applicant/Assignee:

Application No.: 09/633424   Filing Date: 07/Aug/2000

Abstract:

A therapeutic composition and a method of using the composition are provided. The composition includes an osmotic agent and an active agent. The osmotic agent improves the delivery of the active agent to the targeted tissue site.

Priority: US1999-439858 Applic. Date: 1999-11-12

Inventor: HODOSH MILTON [US]


Patent No.: US6524625B2  Issued: 25/Feb/2003

Title: Physiologically active extract obtained from indigo plant polygonum tinctorium

Applicant/Assignee: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUTO

Application No.: 09/339928   Filing Date: 25/Jun/1999

Abstract:

A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4'-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4'-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.

Priority: JP19980183608 Applic. Date: 1998-06-30; JP19980306776 Applic. Date: 1998-10-28; JP19990110852 Applic. Date: 1999-04-19; JP19990133597 Applic. Date: 1999-05-14

Inventor: AGA HAJIME [JP]; ARAI SHIGEYUKI [JP]; FUKUDA SHIGEHARU [JP]; KUNIKATA TOSHIO [JP]; KURIMOTO MASASHI [JP]


Patent No.: US6528022B1  Issued: 04/Mar/2003

Title: Ozone generating apparatus and corona generating apparatus

Applicant/Assignee:

Application No.: 09/714957   Filing Date: 20/Nov/2000

Abstract:

One of the electrodes is covered an insulated material outer skin and is formed with a long wire shape, a band shape or a plate shape. Another of the electrodes is formed with a bare wire by suiting the various shapes and is formed along another insulated core wire and is arranged closely contact with a parallel shape, a right angle shape, a spiral shape, a net shape or a zigzag shape. Accordingly it is possible to lower the voltage. The both electrodes are separated electrically and mechanically using an insulated material and in an ozone generation portion the both electrodes are separated completely.

Priority: JP19990375963 Applic. Date: 1999-11-29

Inventor: KINOSHITA YUKIO [JP]


Patent No.: US6528073B2  Issued: 04/Mar/2003

Title: Solid cosmetic composition and uses thereof

Applicant/Assignee: L'OREAL

Application No.: 09/867381   Filing Date: 31/May/2001

Abstract:

A solid composition for topical application comprising, in an aqueous phase, a gelling system comprising (i) gellan gum, (ii) at least one other hydrocolloid chosen from the group formed by xanthan gum, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, agar-agar, carrageenans, alginates, carob gum, guar gum, gum arabic, karaya gum, gum tragacanth, ghatti gum, pectins, gelatin, caseinates and hydroxypropylguar, and (iii) at least one amphiphilic polymer comprising at least one fatty chain and at least one hydrophilic unit.

Priority: FR19980009793 Applic. Date: 1998-07-30; US1999-357956 Applic. Date: 1999-07-21

Inventor: ROULIER VERONIQUE [FR]; QUEMIN ERIC [FR]


Patent No.: US6528080B2  Issued: 04/Mar/2003

Title: Biodegradable polymer composition

Applicant/Assignee: ATRIX LABORATORIES, INC

Application No.: 10/047483   Filing Date: 14/Jan/2002

Abstract:

A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

Priority: US1999-442203 Applic. Date: 1999-11-16

Inventor: DUNN RICHARD L [US]; ENGLISH JAMES P [US]


Patent No.: US6531116B1  Issued: 11/Mar/2003

Title: Treatment regime for skin

Applicant/Assignee: CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC

Application No.: 09/177695   Filing Date: 22/Oct/1998

Abstract:

A method for a skin treatment regime and a respective product is provided which cosmetically improves human skin. The product includes a first composition containing at least one active and functioning to impart a first benefit to the skin. A second composition is provided which includes a second different active and imparts a second benefit to the skin. The first and second compositions are stored in respective separate containers, which nevertheless are joined together for reminding a consumer to use the compositions in tandem and to facilitate in one sale all necessary elements of a suggested regime. Packaging suitable for this purposes can be a series of stackable jars releasably lockable together through a threaded screw arrangement one above the other.

Priority: US1996-670389 Applic. Date: 1996-06-25

Inventor: SUARES ALAN [US]; NETTESHEIM SUSAN [US]; INDURSKY MICHAEL [US]; BERTOLINI PETER [US]


Patent No.: US6531118B1  Issued: 11/Mar/2003

Title: Topical compositions with a reversible photochromic ingredient

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 10/014167   Filing Date: 11/Dec/2001

Abstract:

There are provided topical compositions having reversible visible change in color in response to change in light. The compositions comprise color changing capability provided by photochromic material and a vehicle acceptable for topical application to the skin or hair.

Priority:

Inventor: GONZALEZ ANTHONY D [US]; PECHKO ANDREW H [US]; KALAFSKY ROBERT E [US]


Patent No.: US6531132B1  Issued: 11/Mar/2003

Title: Process for the extraction of an active principle from yeast for the treatment of wrinkles and cosmetic compositions thereof

Applicant/Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE (SILAB)

Application No.: 09/630611   Filing Date: 02/Aug/2000

Abstract:

A process for extracting an active principle from yeast whereby the active principle is used to retard the degradation of the dermo-epidermal junction to improve the surface condition of the skin. The process includes forming a mixture of solubilized ground yeast in a basic medium, hydrolyzing the proteins of the mixture in a basic medium, agitating the mixture for 8 to 52 hours, filtering the mixture to separate the soluble and insoluble phases, washing with water so as to purify the active ingredient, concentrating and filtering to increase an active oligosaccharide fraction, and sterile filtering the active fraction. The active fraction is characterized by a quantity of dry material between 10 and 200 g/l, a quantity of total sugar between 10 and 100 g/l, a weight ratio of sugar/protein, and a pH between 4 and 10.

Priority: FR19990010152 Applic. Date: 1999-08-02

Inventor: PAUFIQUE JEAN-JACQUES [FR]


Patent No.: US6531140B2  Issued: 11/Mar/2003

Title: ANTI-IRRITANT COMPOSITIONS CONTAINING A CYCLIC NUCLEOTIDE

Applicant/Assignee: E-L MANAGEMENT

Application No.: 09/304562   Filing Date: 04/May/1999

Abstract:

The present invention relates to cosmetic or pharmaceutical topical compositions containing at least one cyclic nucleotide having its 2' hydroxyl group replaced by a hydrogen atom for inhibiting phosphodiesterase activity. The phosphodiesterase inhibitor is in combination with a magnesium buffer and a cosmetically or pharmaceutically acceptable carrier. The invention also includes methods for treating or preventing inflammation or irritation such as is common in the skin disease, atopic dermatitis, which is known to be related to the uncontrolled activity of phosphodiesterase.

Priority:

Inventor: MAMMONE THOMAS [US]; GOYARTS EARL C [US]; MUIZZUDDIN NEELAM [US]


Patent No.: US6531149B1  Issued: 11/Mar/2003

Title: Estradiol-containing patch for transdermal application of hormones

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/744711   Filing Date: 04/Apr/2001

Abstract:

An active substance-containing patch for controlled release of estradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to the human or animal skin, consisting of a backing layer, an active substance-containing reservoir connected thereto which is suitable for combined active substance release and which has been produced using pressure-sensitive adhesives, and a detachable protective layer, is characterized in that the pressure-sensitive adhesive contains wool wax or components thereof and zinc oxide.

Priority: DE19981034007 Applic. Date: 1998-07-29; WO1999EP05085 Applic. Date: 1999-07-16

Inventor: KIRSTGEN ELVIRA [DE]; MECONI REINHOLD [DE]


Patent No.: US6534070B1  Issued: 18/Mar/2003

Title: Composition with azelaic acid

Applicant/Assignee: SCHERING AKTIENGESELLSCHAFT

Application No.: 09/554738   Filing Date: 21/Aug/2000

Abstract:

The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.

Priority: DE19971053044 Applic. Date: 1997-11-19; DE19981008086 Applic. Date: 1998-02-20; WO1998EP07370 Applic. Date: 1998-11-18; US19980074850P Applic. Date: 1998-02-12

Inventor: FRANKE PATRICK [DE]; GUENTHER CLEMENS [DE]; RIEDL JUTTA [DE]


Patent No.: US6534072B2  Issued: 18/Mar/2003

Title: Process for increasing the persistence of at least one cosmetic effect and/or care effect of a cosmetic composition, cosmetic composition and use thereof

Applicant/Assignee: L'OREAL

Application No.: 09/848237   Filing Date: 04/May/2001

Abstract:

The present invention relates to a process for increasing the persistence of at least one cosmetic and/or care effect of a cosmetic composition comprising an oily phase. This process comprises the incorporation into this oily phase of at least one linear or cyclic polyorganosiloxane which comprises at least two organosiloxy units and at least two side and/or end groups which are each capable of forming at least one hydrogen bond with one or more partner groups. The process may be applied, for example, to lipsticks, mascaras or eyeliners to increase the persistence of their coloring effect and/or gloss, to foundations, powders, blushers and eyeshadow to increase the persistence of the matt effect, and to care products such as moisturizing products, deodorants or antiperspirants to increase the persistence of their active care agents.

The invention also relates to a cosmetic composition, the persistence of at least one cosmetic and/or care effect of which is increased, and which is intended to be used on the skin, the lips and superficial body growths.

Priority: FR20000005878 Applic. Date: 2000-05-09

Inventor: MONDET JEAN [FR]; MOUGIN NATHALIE [FR]


Patent No.: US6534543B2  Issued: 18/Mar/2003

Title: Oxa acids and related compounds for treating skin conditions

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 09/957923   Filing Date: 21/Sep/2001

Abstract:

The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compoundswherein R4 is (CR5R6-CR7R81-X1)n-CR9R10R11

n is an integer from 1 to 18

R1, R2, R3, R5, R6, R7, R8, R9, R10 and R11, are independently, herein defined and X, X1, Y and Z are independently, 0, NH or S.

Priority: US2000-566556 Applic. Date: 2000-05-08; US1997-920239 Applic. Date: 1997-08-28; US1997-863502 Applic. Date: 1997-06-02; US1996-658089 Applic. Date: 1996-06-04

Inventor: PTCHELINTSEV DMITRI [US]; SCANCARELLA NEIL [US]; KALAFSKY ROBERT [US]


Patent No.: US6537527B1  Issued: 25/Mar/2003

Title: Skin lightening compositions

Applicant/Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER

Application No.: 09/133861   Filing Date: 13/Aug/1998

Abstract:

This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo

m is 1 to 4

each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR

each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl

n is 1 to 5

Z is O

in an amount effective to lighten skin

and a pharmaceutically-acceptable carrier therefor.

Priority: US1995-390152 Applic. Date: 1995-02-24; US1994-206573 Applic. Date: 1994-03-04

Inventor: KVALNES KALLA LYNN [US]; DELONG MITCHELL ANTHONY [US]; BRADBURY BARTON JAMES [US]; MOTLEY CURTIS BOBBY [US]; CARTER JOHN DAVID [US]


Patent No.: US6538039B2  Issued: 25/Mar/2003

Title: PHARMACEUTICAL DOSAGE FORM FOR TRANSDERMAL ADMINISTRATION

Applicant/Assignee: LABORATOIRE L. LAFON

Application No.: 08/741967   Filing Date: 31/Oct/1996

Abstract:

The present invention relates to a process for administering an active principle to a patient transdermally, which comprises the formation of a film on the patient's skin, by applying to the skin a liquid solution which consists essentially of:a) a lipophilic active principle,b) from 2.5 to 25% by weight of a silicone-based adhesive polymer composition,c) from 0 to 25% by weight of an absorption promoter, andd) from 25 to 95% by weight of volatile solvents comprising volatile silicones.

Priority: FR19940005272 Applic. Date: 1994-04-29; US1995-428958 Applic. Date: 1995-04-26

Inventor: LAURENT PHILIPPE [FR]


Patent No.: US6540988B1  Issued: 01/Apr/2003

Title: Method of reducing or preventing malodour

Applicant/Assignee: QUEST INTERNATIONAL B.V

Application No.: 09/743135   Filing Date: 05/Jan/2001

Abstract:

A method of reducing or preventing body malodour by topically applying to human skin perfume components capable of inhibiting the producation of odoriferous steroids by microorganisms on the skin. The perfume components are capable of inhibiting bacterial 4-ene reductase and/or 5alpha-reductase.

Priority: GB19980014646 Applic. Date: 1998-07-07; WO1999GB02170 Applic. Date: 1999-07-06

Inventor: BEHAN JOHN M [GB]; MINHAS TONY [GB]


Patent No.: US6541018B1  Issued: 01/Apr/2003

Title: Nanoemulsion based on glycerol fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/461753   Filing Date: 16/Dec/1999

Abstract:

The present invention provides a nanoemulsion, that includes:an oily phase dispersed in an aqueous phase

andat least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45 DEG C.

wherein the oily phase includes oil globules having a number-average size of less than 100 nm

wherein the oily phase includes at least one oil having a molecular weight of greater than 400

andwherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.

Priority: FR19980015950 Applic. Date: 1998-12-17

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6541670B2  Issued: 01/Apr/2003

Title: Aminobenzophenones as inhibitors of IL 1beta and TNF-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD. A/S

Application No.: 09/787532   Filing Date: 20/Mar/2001

Abstract:

A compound of the general formula IwhereinR1 represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, and nitro

R2 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, and nitro

R3 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, carbamoyl, (C1-C10)alkyl, (C2-C10)olefinic group, (C3-C8)monocyclic hydrocarbon group, (C1-C10)alkoxy, (C1-C10)alkylthio, (C1-C10)alkoxycarbonyl, and phenyl

R4 represents hydrogen, (C1-C6)alkyl, (C2-C6)olefinic group, or (C3-C6)monocyclic hydrocarbon group

R5 represents one or more, same or different substituents selected from the group consisting of hydrogen and R1

X represents oxygen, sulphur, or N-OH

and salts thereof with pharmaceutically acceptable acids, hydrates and solvates, may be used in the prophylaxis or treatment of inflammatory diseases.

Priority: WO2000DK00653 Applic. Date: 2000-11-29; US19990169333P Applic. Date: 1999-12-06

Inventor: OTTOSEN ERIK RYTTER [DK]


Patent No.: US6544290B1  Issued: 08/Apr/2003

Title: Cell seeding of ceramic compositions

Applicant/Assignee: ETEX CORPORATION

Application No.: 09/023340   Filing Date: 13/Feb/1998

Abstract:

The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.

Priority: US1996-729354 Applic. Date: 1996-10-16; US1996-650764 Applic. Date: 1996-05-20; US1995-446182 Applic. Date: 1995-05-19

Inventor: LEE DOSUK D [US]; REY CHRISTIAN [FR]; AIOLOVA MARIA [US]


Patent No.: US6544531B1  Issued: 08/Apr/2003

Title: Skin care composition

Applicant/Assignee: JOHNSON & JOHNSON PRODUCTS, INC

Application No.: 09/436867   Filing Date: 09/Nov/1999

Abstract:

There are provided compositions which include a retinoid and preferably retinol

a dermatologically active acid

and a volatile base, such as ammonium hydroxide. Another embodiment of the invention includes compositions comprising a retinoid and preferably retinol

a dermatologically active acid

a volatile base

and a second neutralizing agent. There are also provided compositions which include a retinoid, a neutralized ammonium salt of a dermatologically active acid, and optionally a neutralized salt, other than ammonium salt, of an acid. Further provided are methods for reducing fine lines, wrinkles, skin roughness, and pore size and for increasing the clarity of a skin surface, cellular turnover, skin radiance, skin smoothness, skin permeation or collagen synthesis in a mammal in need thereof. Compositions as described above are administered topically to the skin of the animal.

Priority: US1999-325452 Applic. Date: 1999-06-03; US19980107956P Applic. Date: 1998-11-12

Inventor: COLE CURTIS A [US]; FLACK LAURA E [US]; KAMINSKI CLAUDIA [US]; LEEUWEN VICTORIA VAN [FR]


Patent No.: US6544532B1  Issued: 08/Apr/2003

Title: Composition containing an unstable active agent in an oxidizing medium and uses thereof, especially cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/701366   Filing Date: 25/Jan/2001

Abstract:

The invention relates to a composition containing, in a physiologically acceptable medium, an unstable active agent in an oxidizing medium and an oil phase comprising cross-linked elastomer solid organopolysiloxane particles consisting of at least one oxyalkylene group and oxyethylene in particular. The unstable active agent in an oxidizing medium is stabilized in the inventive composition. The invention also relates to the use of cross-linked elastomer solid organopolysiloxane particles having an oxyalkylene group for the stabilization of an unstable active agent in an oxidizing medium. The unstable active agent can be vitamin C, vitamin A and/or carotenoids. The composition can be anhydrous or take the form of an emulsion. It is particularly suitable for use in cosmetics. It is soft and fresh when applied, spreads easily, is not sticky and does not make the skin or lips dry.

Priority: FR19990004046 Applic. Date: 1999-03-31; WO2000FR00705 Applic. Date: 2000-03-21

Inventor: JAGER-LEZER NATHALIE [FR]; LORANT RALUCA [FR]


Patent No.: US6544533B2  Issued: 08/Apr/2003

Title: 10-hydroxy-2-decenoic acid compounds for promoting desquamation/epidermal renewal of the skin and/or combating skin aging

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/811424   Filing Date: 20/Mar/2001

Abstract:

10-Hydroxy-2-decenoic acid compounds, particularly the 10-hydroxydec-2-enoates, are well suited for promoting desquamation of human skin and/or stimulating epidermal renewal and thus combating intrinsic and/or extrinsic cutaneous aging.

Priority: FR19980011810 Applic. Date: 1998-09-22; WO1999FR02230 Applic. Date: 1999-09-20

Inventor: BRETON LIONEL [FR]; PINEAU NATHALIE [FR]; BENECHIE EMILE [FR]; LI MARTINE [FR]; PICOT FRANCOISE [FR]; POTIER PIERRE [FR]


Patent No.: US6546281B1  Issued: 08/Apr/2003

Title: Integrated apparatus for controlled heat aided dermal drug delivery

Applicant/Assignee: ZARS, INC

Application No.: 09/317372   Filing Date: 24/May/1999

Abstract:

An integrated apparatus for controlled heat aided dermal drug delivery is disclosed. The apparatus has a temperature control component and a drug delivery component. The temperature control component may and dermal drug delivery component are an integrated unit. The apparatus also comprises means to prevent exchange of substance(s) among the heat generating component, the drug delivery component and the outside environment. The apparatus is designed to be easy to use.

Priority: US1998-162890 Applic. Date: 1998-09-29; US1997-819880 Applic. Date: 1997-03-18; US1995-508463 Applic. Date: 1995-07-28

Inventor: ZHANG JIE [US]; ZHANG HAO [US]; HULL WADE A [US]; RIGBY LARRY [US]


Patent No.: US6548050B1  Issued: 15/Apr/2003

Title: Make-up or care composition containing a crosslinked polyorganosiloxane containing an oxyalkylenated group

Applicant/Assignee: L'OREAL

Application No.: 09/538495   Filing Date: 30/Mar/2000

Abstract:

The present invention provides a dermatologic or cosmetic composition, including a liquid fatty phase, and, as surfactant and thickener for the liquid fatty phase, particles of a crosslinked elastomeric solid polyorganosiloxane containing at least one oxyalkylenated group. Another embodiment of the invention relates to methods of using particles of a crosslinked elastomeric solid polyorganosiloxane containing at least one oxyethylenated group. The present invention is especially suitable for a care or make-up composition for human skin and lips, and overcomes the various drawbacks in known compositions. In particular, the present invention provides a composition for human skin and lips that results in a film that does not transfer

that has better cosmetic properties, freshness and matte-effect properties

and that is desirably longer-lasting than conventional "transfer-resistant" products, in particular the properties of slipperiness, of not feeling taut and of not drying out the lips, of having good staying power over time, particularly with respect to the color (no color change over time) and of not migrating, in particular into the folds of the skin. The invention applies not only to make-up products for human lips and skin, but also to care and/or treatment products for human lips and skin. The composition of the invention can also be applied to the scalp.

Priority: FR19990003967 Applic. Date: 1999-03-30

Inventor: BARA ISABELLE [FR]


Patent No.: US6551604B1  Issued: 22/Apr/2003

Title: Skin care compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/807151   Filing Date: 08/Nov/2001

Abstract:

The present invention relates to topical compositions for effecting an immediate improvement in the appearance and feel of skin, in addition to providing chronic improvements in skin appearance. The compositions comprise from 0.5% to 25% of a first particulate material having a refractive index of from 1.3 to 1.7, the particulate material being dispersed in the composition and having a median particle size of from 2 to 30 um, and an active effective for chronically regulating skin condition selected from Vitamin B3 compounds, retinoids, and mixtures thereof. Preferred emobodiments are oil in water emulsions further comprising a second particulate material having a larger particle size than the first.

Priority: WO1999US14569 Applic. Date: 1999-06-28

Inventor: BECK PETRA HELGA [GB]; DATE ROBERT FRANCIS [GB]; TREMBLAY MARIO ELMEN [US]


Patent No.: US6551606B1  Issued: 22/Apr/2003

Title: Cosmetic product containing enzymes

Applicant/Assignee: COTY B.V

Application No.: 10/018213   Filing Date: 05/Dec/2001

Abstract:

The invention relates to a cosmetic product that contains enzymes and has an intensive skin action, especially a regenerative effect The inventive cosmetic product contains 0.01 to 5 wt. % of a concentrate of the coconut milk of Cocos nucifera, containing peroxidase, lipase and protease

0.1 to 10 wt. % of a plant milkwater, the plants being selected from the following group: banana, dandelion, convolvus, poppy, soya and mixtures thereof

and 0.01 to 5 wt. % of a glycerol extract of a mixture consisting of honey, rice hulls, rice hull oil and/or rice germ oil

with the remainder consisting of cosmetic auxiliary agents, active agents and carrier substances.

Priority: DE19991027229 Applic. Date: 1999-06-10; WO2000DE01891 Applic. Date: 2000-06-08

Inventor: GOLZ-BERNER KARIN [DE]; ZASTROW LEONHARD [DE]


Patent No.: US6551619B1  Issued: 22/Apr/2003

Title: Pharmaceutical cyclosporin formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation

Applicant/Assignee: PHARMATEC INTERNATIONAL S.R.L

Application No.: 09/674417   Filing Date: 22/Jan/2001

Abstract:

The invention relates to solid, particulate lipid-based excipients which are loaded with cyclosporine. Said excipients have improved biopharmaceutical properties for cyclosporines in vivo, are of a better quality (in terms of fineness, homogeneity of the particles, inclusion of the medicament) and are more physically stable in the particulate formulation (no aggregation or gel formation). The invention also relates to a therapeutic treatment with cyclosporine formulations which produce an average blood level concentration in the steady state range of 300 ng/ml to over 1000 ng/ml, preferably over 800 ng/ml, especially up to 900 ng/ml, preferably 400 ng/ml to 800 ng/ml in the absence of high initial blood level concentrations essentially over 1500 ng/ml, especially over 1200 ng/ml. This blood level concentration is preferably maintained for an extended period of at least 5 hours, preferably at least 7 hours.

Priority: DE19981019273 Applic. Date: 1998-04-30; WO1999EP02892 Applic. Date: 1999-04-29

Inventor: PENKLER LAWRENCE JOHN [ZA]; MUELLER RAINER HELMUT [DE]; RUNGE STEPHAN ANTON [DE]; RAVELLI VITTORINO [IT]


Patent No.: US6552021B2  Issued: 22/Apr/2003

Title: Pharmaceutical compounds

Applicant/Assignee: XENOVA LIMITED

Application No.: 09/797902   Filing Date: 05/Mar/2001

Abstract:

A compound which is a heteroaromatic[a]phenazine carboxamide derivative of formula (I)wherein X is a five- or six-membered heteroaromatic ring which contains one or two nitrogen atoms and which is unsubstituted or substituted by C1-C6 alkyl, hydroxyl or C1-C6 alkoxy

Q is C1-C6 alkylene which is unsubstituted or substituted by C1-C6 alkyl which is unsubstituted or substituted by a hydroxy group

andR1 and R2 which are the same or different are each C1-C6 alkyl

or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of topoisomerase I and II and can be used to treat tumours, including tumours which express MDR.

Priority: GB20000005366 Applic. Date: 2000-03-06

Inventor: MILTON JOHN [GB]; VICKER NIGEL [GB]; DENNY WILLIAM ALEXANDER [NZ]; GAMAGE SWARNALATHA AKURATIYA [NZ]; SPICER JULIE ANN [NZ]


Patent No.: US6552208B1  Issued: 22/Apr/2003

Title: Fractionation process

Applicant/Assignee: KARLSHAMNS AB

Application No.: 09/701392   Filing Date: 18/Jan/2001

Abstract:

The invention refers to a process for fractionating a vegetable oil giving one or more solid fractions suitable for confectionary applications as well as a liquid fraction rich in unsaponifiable biologically active components. The liquid fractions of shea butter and rapeseed oil having a high content of phytosterols and tocoferols, respectively, are useful for cosmetical and pharmaceutical preparations.

Priority: SE19980001955 Applic. Date: 1998-06-02; WO1999SE00945 Applic. Date: 1999-06-01

Inventor: ALANDER JARI [SE]; ANDERSSON ANN-CHARLOTTE [SE]; MALMROS HAAKAN [SE]; NILSSON JOERGEN [SE]


Patent No.: US6553255B1  Issued: 22/Apr/2003

Title: Use of background electrolytes to minimize flux variability during iontophoresis

Applicant/Assignee: ACIONT INC

Application No.: 09/698697   Filing Date: 27/Oct/2000

Abstract:

A device and method are provided that minimize the changes in flux encountered during iontophoresis and reduce inter-subject variability. For drug delivery, the active agent to be delivered is administered in conjunction with at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the active agent when an electrical current is applied. For analyte extraction, the extraction reservoir contains at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the background ions of the analyte in the tissue when an electrical current is applied.

Priority:

Inventor: MILLER DAVID J [US]; LI KEVIN [US]; HIGUCHI WILLIAM I [US]


Patent No.: US6555095B1  Issued: 29/Apr/2003

Title: Topical compositions and methods of application

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 10/017552   Filing Date: 14/Dec/2001

Abstract:

There are topical emulsion compositions having a cosmetic drug or medicinal active, a novel compound of the present invention, and a vehicle. The novel compound is represented by a formula selected from the group consisting of L-A-H and A-L-H, wherein L is a lipophilic moiety, A is an aromatic moiety, and H is a hydrophilic moiety. Also provided are methods of emulsifying a composition

improving the photostability of a composition

and enhancing the effectiveness of a sunscreen composition.

Priority:

Inventor: GARRISON MARK S [US]


Patent No.: US6555131B1  Issued: 29/Apr/2003

Title: Therapeutical system for transdermal delivery of levonorgestrel

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 09/462009   Filing Date: 09/Mar/2000

Abstract:

A stable therapeutical transdermal system for the transcutaneous delivery of levonorgestrel, alone or together with other sex steroid hormones, over a long time period is disclosed. A method of producing the transdermal system that avoids the use of solvents and avoids degradation of the steroid hormones also is disclosed.

Priority: DE19971028516 Applic. Date: 1997-07-04; WO1998EP04079 Applic. Date: 1998-07-02

Inventor: WOLFF HANS-MICHAEL [DE]; ARTH CHRISTOPH [DE]


Patent No.: US6555573B2  Issued: 29/Apr/2003

Title: Method and composition for the topical treatment of diabetic neuropathy

Applicant/Assignee: THE QUIGLEY CORPORATION

Application No.: 09/740811   Filing Date: 21/Dec/2000

Abstract:

A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect.

In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment,In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recover of the damaged nerve tissues.

Priority:

Inventor: ROSENBLOOM RICHARD ALLEN [US]


Patent No.: US6555710B1  Issued: 29/Apr/2003

Title: Aminobenzophenones as inhibitors of IL-1 beta and TNF-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB

Application No.: 10/031071   Filing Date: 15/Mar/2002

Abstract:

The present invention relates to compounds of formula (I) wherein R1 and R2 independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl, or nitro

R2 further being represented by hydrogen

R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, phenyl, cyano, carboxy or carbomoyl

R4 represents hydrogen, (C1-C3)alkyl, or allyl

X represents oxygen or sulpher

with the proviso that formula (I) does not comprise the compound 2,2,2-trifluoro-N-[2-[3-chloro-4-(2-methylbenzoyl)-phenylamino]-phenyl]acetamide wherein R1 is a 2-methyl, R2 is 2-chloro, R3 and R4 is hydrogen, and X is oxygen

and a salt thereof with a pharmaceutically acceptable acid, a hydrate or a solvate thereof. The compounds are valuable in the human and veterinary therapy.

Priority: WO2000DK00388 Applic. Date: 2000-07-11; US19990144169P Applic. Date: 1999-07-16

Inventor: OTTOSEN ERIK RYTTER [DK]


Patent No.: US6562354B1  Issued: 13/May/2003

Title: Composition in the form of a water-in-oil emulsion having an evolutive shear rate

Applicant/Assignee: L'OREAL

Application No.: 09/611312   Filing Date: 06/Jul/2000

Abstract:

The present provides a composition that includes, in a physiologically acceptable medium:an aqueous phase dispersed in an oily phase with a silicone emulsifier

wherein the aqueous phase represents at least 80% by weight relative to the total weight of the composition

wherein the silicone emulsifier is an alkyldimethicone copolyol comprising an HLB of less than 8

andwherein a weight ratio of the oily phase to the silicone emulsifier is greater than or equal to 5. The present invention also provides a cosmetic, which includes the above-mentioned composition and methods of using the above-mentioned composition for treating, protecting, caring for, or removing make-up from the skin, lips or hair, cleansing the skin, lips or hair, and making up the skin or lips, treating, protecting, and caring for the scalp, and treating greasy skin. The composition can be used in particular in cosmetics and/or dermatology.

Priority: FR19990008712 Applic. Date: 1999-07-06

Inventor: AFRIAT ISABELLE [US]; BOULIER VIRGINIE [FR]


Patent No.: US6562355B1  Issued: 13/May/2003

Title: Comixture of dextran sulfate/escin for treating skin redness/edema and/or sensitive skin

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/684986   Filing Date: 10/Oct/2000

Abstract:

Comixtures of escin and dextran sulfate are effective for treating skin redness/edema and/or sensitive skin, particularly redness and/or edema around the eyes and most particularly bags and/or dark rings around the eyes.

Priority: FR19990012589 Applic. Date: 1999-10-08

Inventor: RENAULT BEATRICE [FR]


Patent No.: US6562356B2  Issued: 13/May/2003

Title: Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene glycol (PEG) ester, and uses thereof

Applicant/Assignee: L'OREAL S.A

Application No.: 09/765564   Filing Date: 22/Jan/2001

Abstract:

Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol (PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I):in which:R1 is chosen from linear and branched, saturated and unsaturated alkyl groups comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl groups comprising from 8 to 30 carbon atoms,R2 is chosen from a hydrogen atom, linear and branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, andn is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.

Priority: FR20000000794 Applic. Date: 2000-01-21

Inventor: VERITE CLAUDE [FR]; CAZIN BENEDICTE [FR]; DOUIN VERONIQUE [FR]; AUBRUN ODILE [FR]; SIMONNET JEAN-THIERRY [FR]


Patent No.: US6562367B1  Issued: 13/May/2003

Title: Transdermal therapeutic system (TTS) for administering sexual steroid hormones

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 09/462033   Filing Date: 16/Mar/2000

Abstract:

A transdermal therapeutic system for transcutaneous administration of sexual steroid hormones over long time periods, and a solvent-free method for the production thereof, is disclosed. The steroid hormones are subjected to as little thermal exposure as possible, thereby avoiding decomposition of the steroid hormones.

Priority: DE19971028517 Applic. Date: 1997-07-04; WO1998EP03950 Applic. Date: 1998-06-29

Inventor: WOLFF HANS-MICHAEL [DE]; ARTH CHRISTOPH [DE]


Patent No.: US6562803B2  Issued: 13/May/2003

Title: Hair-growing agent

Applicant/Assignee: KYOWA HAKKO KOGYO CO., LTD

Application No.: 10/073107   Filing Date: 12/Feb/2002

Abstract:

The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I):(wherein R1 represents straight-chain alkyl having an odd number of carbon atoms, straight-chain alkenyl having an odd number of carbon atoms, or straight-chain alkynyl having an odd number of carbon atoms).

Priority: JP20010040350 Applic. Date: 2001-02-16

Inventor: KAMIMURA AYAKO [JP]; TAKAHASHI TOMOYA [JP]; MIMURA TAKASHI [JP]; HONDA SHINKICHI [JP]


Patent No.: US6562804B2  Issued: 13/May/2003

Title: Hair-growing agent

Applicant/Assignee: KYOWA HAKKO KOGYO CO., LTD

Application No.: 10/073113   Filing Date: 12/Feb/2002

Abstract:

The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I):(wherein R1 represents alkyl, alkenyl, alkanoyl or alkenoyl

and when R1 represents alkyl or alkenyl, R2 represents alkyl, alkenyl, alkanoyl or alkenoyl, and when R1 represents alkanoyl or alkenoyl, R2 represents alkyl or alkenyl).

Priority: JP20010040351 Applic. Date: 2001-02-16

Inventor: KAMIMURA AYAKO [JP]; TAKAHASHI TOMOYA [JP]; MIMURA TAKASHI [JP]; HONDA SHINKICHI [JP]


Patent No.: US6563122B1  Issued: 13/May/2003

Title: Fluorescence detection assembly for determination of significant vegetation parameters

Applicant/Assignee: DEUTSCHES ZENTRUM FUR LUFT-UND RAUMFAHRT E.V

Application No.: 09/830697   Filing Date: 30/Apr/2001

Abstract:

A basic assembly configuration for determination of relevant vegetation parameters includes a high repetitive pulsed excitation laser (1) for the stimulation of chlorophyll fluorescence, a fluorescence detector (3) including an imaging and separation optic (4, 5), a trigger and delay electronic (6) to adjust the laser and appropriate detector timing and a detector electronic (7), consisting of a signal recording and processing module. The assembly can be used for determination of relevant vegetation parameters for agricultural, horticultural and greenhouse application.

Priority: WO1998EP06815 Applic. Date: 1998-10-28

Inventor: LUEDEKER WILHELM [DE]; GUENTHER KURT [DE]; DAHN HANS-GUENTER [DE]


Patent No.: US6565834B2  Issued: 20/May/2003

Title: Skin composition

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/079124   Filing Date: 19/Feb/2002

Abstract:

Improved skin compositions which are capable of reducing oil and grease secretion from the skin comprising a combination of niacinamide and a C11-C30 alkyl or alkenyl ester of salicylic acid formulated in a specific carrier such as a vanishing cream base are disclosed.

Priority: IN2001MU00187 Applic. Date: 2001-02-22

Inventor: KINI MRIDULA [IN]; RAJWADE LALITAGAURI [IN]; SONA PUSHKER [IN]; SURIANARAYANAN RAMESH [IN]


Patent No.: US6565862B1  Issued: 20/May/2003

Title: Makeup or care composition comprising a hydrophilic organopolysiloxane

Applicant/Assignee: L'OREAL S.A

Application No.: 09/492519   Filing Date: 27/Jan/2000

Abstract:

A transfer-resistant, mattifying composition comprising, as a thickener, particles of an at least partially crosslinked elastomeric solid organopolysiloxane in suspension in an aqueous phase. The composition is more particularly a composition for caring for or making up the lips, or a foundation composition for making up both the human face and the human body. The composition is soft and fresh on application, spreads easily, is nonsticky, and does not dry out the skin or lips. It is perfectly suited to greasy skin because of its high mattifying power.

Priority: FR19990000957 Applic. Date: 1999-01-28

Inventor: BARA ISABELLE [FR]


Patent No.: US6565863B1  Issued: 20/May/2003

Title: Cosmetic compositions, in particular for cleansing the skin

Applicant/Assignee: L'OREAL

Application No.: 09/648765   Filing Date: 28/Aug/2000

Abstract:

A transparent aqueous composition comprising, in a physiologically acceptable medium, (i) at least one acylisethionate, and (ii) at least one protein hydrolysate containing a hydrophobic group, in an amount which is sufficient to dissolve the acylisethionate in the composition.

Priority: FR19990011521 Applic. Date: 1999-09-15

Inventor: GUILLOU VERONIQUE [FR]; SEBILLOTTE-ARNAUD LAURENCE [FR]


Patent No.: US6565865B2  Issued: 20/May/2003

Title: Topical composition comprising a three membered cyclic compound-based cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/092330   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a three membered functional cyclic bonding agent having the structurewherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and Y represents O, NH, S, or Se

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273905P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6565881B1  Issued: 20/May/2003

Title: Effervescent bath tablet, method of preparing it, and the use thereof

Applicant/Assignee: MARZ PHARMA GMBH & CO.KGAA

Application No.: 09/114796   Filing Date: 13/Jul/1998

Abstract:

The present invention relates to a new type of solid balneological preparations for cosmetic, hygienic and therapeutic use, which has both the properties of a solid bath additive and those of liquid products, and is characterized especially by the addition of lipid components, vesicle forming lipids, tensides and, in some cases, mineral salts. Active components, adjuvants such as stabilizers, adsorbing substances, lubricants as well as smoothing and breakdown promoting agents may also be contained therein.

Priority: DE19971057059 Applic. Date: 1997-12-20

Inventor: NUERNBERG EBERHARD [DE]; JERZEMBEK KERSTIN [DE]; BEUTLER ROLF D [DE]; EBINGER JUERGEN [DE]; WEIS RUTH [DE]


Patent No.: US6566554B1  Issued: 20/May/2003

Title: Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)

Application No.: 10/031075   Filing Date: 22/Feb/2002

Abstract:

The present invention relates to a compound of general formula (I) wherein R1, R2, and R3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)akylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, or nitro

further R2 can be hydrogen, and R3 can be carboxy and carbamoyl

R4 represents hydrogen, (C1-C3)alkyl, or allyl

X represents oxygen or sulphur

Q represents -(CO)-, -(CS)-, or a bond

Y represents (C5-C15)alkyl

(C2-C15)olefinic group

(C3-C10)monocyclic hydrocarbon group

or phenyl

any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R5 defined below

(C1-C4)alkyl substituted by one or more substituents selected for the group R5

or a group of the formula -(Z-O)n-Z, wherein Z is a (C1-C3)alkyl, n is an integer >1

and no continuous linear sequence of atoms in the group Y exceeds 15

R5 represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, -COOH, -CONH2, -CONHR', or COONR'R' wherein R' represents (C1-C3)alkyl

or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.

Priority: WO2000DK00385 Applic. Date: 2000-07-11; US19990144166P Applic. Date: 1999-07-16

Inventor: OTTOSEN ERIK RYTTER [DK]


Patent No.: US6569437B1  Issued: 27/May/2003

Title: Combination of acid protease enzymes and acidic buffers and uses thereof

Applicant/Assignee: ACTIVE ORGANICS

Application No.: 09/354687   Filing Date: 16/Jul/1999

Abstract:

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically 5 acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes that exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises inorganic and/or organic acids or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes.

Priority: US1996-664056 Applic. Date: 1996-06-13

Inventor: BISHOP MICHAEL [US]; GILLIS GLEN [US]; NORTON SCOTT J [US]


Patent No.: US6569438B1  Issued: 27/May/2003

Title: Multiphase stick preparation

Applicant/Assignee: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

Application No.: 09/554304   Filing Date: 14/Feb/2001

Abstract:

An improved stick preparation is provided which is made up of at least two separate phases and at least one phase contains spherical polymer particles which can contain a pigment. The particles provide smoothness to the preparation and can be used to provide an interesting visual appearance to the stick.

Priority: DE19971049760 Applic. Date: 1997-11-11; WO1998EP06892 Applic. Date: 1998-10-30

Inventor: BANOWSKI BERNHARD [DE]; SCHOLZ WOLFHARD [DE]; BORDAT PASCAL [FR]; POEPPL MARION [DE]


Patent No.: US6569840B1  Issued: 27/May/2003

Title: Low-molecular heparin modification and remedy for skin ulcer

Applicant/Assignee:

Application No.: 09/554018   Filing Date: 09/May/2000

Abstract:

The invention is direct to modified heparins, especially low-molecular weight modified heparins that are adapted for used in preparing an agent for treating a skin ulcer. The low-molecular weight modified heparins have been substantially deprived of the anticoagulant activity, yet they retain the ability to bind to cell growth factors, cytokines and cell adhesion molecules.

Priority: JP19970319997 Applic. Date: 1997-11-20; WO1998JP05191 Applic. Date: 1998-11-18

Inventor: YAMASHINA IKUO [JP]; OKAYAMA MINORU [JP]; TODA KEN-ICHI [JP]


Patent No.: US6569866B2  Issued: 27/May/2003

Title: Sustained-release nalmefene preparations and method

Applicant/Assignee:

Application No.: 09/922873   Filing Date: 06/Aug/2001

Abstract:

A nalmefene transdermal delivery system useful for the treatment of human patients suffering from opioid addiction.

Priority: US1998-152834 Applic. Date: 1998-09-14; US1997-866334 Applic. Date: 1997-05-30; US1996-643775 Applic. Date: 1996-05-06

Inventor: SIMON DAVID LEW [US]


Patent No.: US6569906B1  Issued: 27/May/2003

Title: Composition containing a precursor capable of being hydrolysed by glucocerebrosidase

Applicant/Assignee: PIERRE FABRE DERMO-COSMETIQUE

Application No.: 09/856220   Filing Date: 18/May/2001

Abstract:

The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two alpha carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.

Priority: FR19980002888 Applic. Date: 1998-03-10; WO1999FR00521 Applic. Date: 1999-03-09

Inventor: REDOULES DANIEL [FR]; TARROUX ROGER [FR]; PERIE JEAN-JACQUES [FR]


Patent No.: US6572870B2  Issued: 03/Jun/2003

Title: Anhydrous cosmetic makeup composition containing a fatty phase

Applicant/Assignee: L'OREAL

Application No.: 09/905938   Filing Date: 17/Jul/2001

Abstract:

An anhydrous cosmetic makeup composition contains in addition to a fatty phase formed from oils, fatty bodies and surfactants, and optionally waxes, a vesicular lipidic phase that contains at least one ionic or nonionic amphiphilic lipid and optionally additives. The anhydrous composition also preferably contains at least one cosmetically and/or dermopharmaceutically active material. In the presence of an aqueous phase these compositions release vesicles of the vesicular lipidic phase and potentialize the activity of the cosmetically and/or dermopharmaceutically active material of the composition.

Priority: FR19910011985 Applic. Date: 1991-09-30; US2000-630957 Applic. Date: 2000-08-02; US1992-954362 Applic. Date: 1992-09-29

Inventor: RIBIER ALAIN [FR]; SIMMONET JEAN-THIERRY [FR]; MIGUEL DOLORES [FR]


Patent No.: US6572892B1  Issued: 03/Jun/2003

Title: Cosmetic or dermopharmaceutical composition in the form of beads and methods for preparing same

Applicant/Assignee:

Application No.: 09/719852   Filing Date: 19/Mar/2001

Abstract:

The invention concerns an anhydrous solid composition comprising at least a hydrophobic wax, an oil and talcum, having preferably the form of beads with size ranging from 1 to 10000 microns. The beads can contain a cosmetic or pharmaceutical active principle, pigments or an agri-food constituent. The invention also concerns the method for preparing said beads.

Priority: FR19980007612 Applic. Date: 1998-06-17; WO1999FR01445 Applic. Date: 1999-06-16

Inventor: IOULALEN KARIM [FR]; RAYNAL ROSANNE [FR]


Patent No.: US6573255B1  Issued: 03/Jun/2003

Title: Vitamin D analogues

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD., A/S

Application No.: 10/048363   Filing Date: 01/Feb/2002

Abstract:

Vitamin D compounds formula Iwherein R represents hydrogen, or R represents (C1-C6)alkyl, phenyl, or (C7-C9)aralkyl, optionally substituted with one or more groups selected from (C1-C3)alkyl, F, phenyl

n is an integer having the value 0, 1, or 2

and X represents hydroxy or halogen.

Priority: WO2000DK00389 Applic. Date: 2000-07-11; US19990147200P Applic. Date: 1999-08-04

Inventor: BRETTING CLAUS AAGE SVENSGAARD [DK]


Patent No.: US6573299B1  Issued: 03/Jun/2003

Title: Method and compositions for treatment of the aging eye

Applicant/Assignee: ADVANCED MEDICAL INSTRUMENTS

Application No.: 09/399393   Filing Date: 20/Sep/1999

Abstract:

This invention relates to a method for the prevention and treatment of orbital disorders associated with the aging eye in mammals by the application of a topical composition comprising a permeation enhancing amount of one or more penetration enhancers, and one or more bio-affecting agents which penetrate into the underlying tissues and into the vascular network of the orbit. Another object of this invention is the improvement of age-related changes to the eyelids such as dry skin, wrinkles, keratoses, age spots and pigmented skin lesions. It is a further object of this invention to prevent and treat cataract formation, glaucoma, diabetic retinopathy and macular degeneration.

Priority:

Inventor: PETRUS EDWARD J [US]


Patent No.: US6576223B2  Issued: 10/Jun/2003

Title: INSECT REPELLENT

Applicant/Assignee: KARL ENGELHARD FABRIK PHARM PRAPARATE GMBH & CO. KG

Application No.: 09/451016   Filing Date: 29/Nov/1999

Abstract:

An insect-repelling agent contains N,N-diethyl-m-toluamide (DEET) based on alcohol solutions as the active ingredient (repellent), and further contains an adjuvant that extends the period of effectiveness of DEET following application to human skin. It is proposed that the sole adjuvant is glycerol in an amount of more than 10 percent by weight of the insect-repelling.

Priority: DE19971022196 Applic. Date: 1997-05-27; WO1998EP03008 Applic. Date: 1998-05-22

Inventor: RUNKEL FRANK [DE]


Patent No.: US6579836B1  Issued: 17/Jun/2003

Title: Agents for eliminating the adhesive capacity of helminth eggs

Applicant/Assignee: MENNO CHEMIE VERTRIEBSGES, MBH

Application No.: 09/831542   Filing Date: 09/Aug/2001

Abstract:

The invention relates to detergents for removing adherent helminth eggs from the bristles, skin, fur and feathers of live animals. The detergents are based on an active mixture that can contain anion-active and/or non-ionic tensides, aromatic carboxylic acids, glycol ether, hydrotropic agents and oxygen donors and that is characterised in that it contains active combinations of aromatic carboxylic acids, preferably benzoic acid and o-hydroxybenzoic acid, individually or mixed, and/or their sodium, potassium or ammonium salts in conjunction with alkyl sulfonates or sulfates and/or alkylaryl sulfonates or sulfates with primary and/or secondary chains of the length C8-C18 and their sodium, potassium or ammonium salts as anionic tensides and alkylpolyethylene glycol ether [RnO (CH2CH2O)xH

n=C2-C10

x=3, 5, 6, 7, 8, 11] as non-ionogenic tensides, in that they contain triethylene glycol dimethylether, tetraethylene glycoldimethylether and n-hexyldiglycol (diethylene glycol-mono-n-hexylether) individually or mixed with each other, in that they contain toluol sulfonate and/or cumol sulfonate in the form of a sodium or a potassium salt as a solutizer, individually or mixed, and in that they contain potassium peroximonosulfate (triple salt), hydrogen peroxide, perborate or percarbonate and their sodium or potassium salts as oxygen donors.

Priority: DE19981051662 Applic. Date: 1998-11-10; WO1999EP06768 Applic. Date: 1999-09-13

Inventor: NEVERMANN JAN [DE]


Patent No.: US6579907B1  Issued: 17/Jun/2003

Title: Foaming oil-in-water emulsion based on nonionic surfactants, a fatty phase and a crosslinked cationic or anionic polymer, and its use in topical applications

Applicant/Assignee: L'OREAL S.A

Application No.: 09/502491   Filing Date: 11/Feb/2000

Abstract:

A forming oil-in-water emulsion in the form of a cream comprising, in an aqueous medium, at least:a) from 5 to 20% of an exclusively nonionic surfactant system comprising at least one foaming nonionic surfactant

b) from 10 to 50% of an oily phase containing at least one water-insoluble oil whose solubility parameters dD, dP and dH according to Hansen's solubility space satisfy the conditions:andwithc) and, as a gelling agent, at least one crosslinked homopolymer or copolymer formed from at least one cationic or anionic monomer containing ethylenic unsaturation and from a crosslinking agent containing polyethylenic unsaturation. This composition is useful in cosmetics, dermatology and hygiene as a base for cleansing products for the skin, the hair, the mucous membranes and the scalp.

Priority: FR19950004924 Applic. Date: 1995-04-25; US1998-187036 Applic. Date: 1998-11-06; US1996-636555 Applic. Date: 1996-04-23

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]; AMBROSINI EMMANUELLE [FR]; ARNAUD PASCAL [FR]


Patent No.: US6582688B1  Issued: 24/Jun/2003

Title: Method for extracting compounds of furan lipids and polyhydroxylated fatty alcohols of avocado, composition based on said compounds, and therapeutic, cosmetical or food use of said compounds

Applicant/Assignee: PHARMASCIENCE

Application No.: 10/088077   Filing Date: 20/Mar/2002

Abstract:

The invention concerns a method for selectively extracting furan lipids and polyhydroxylated fatty alcohols of avocado, characterised in that it comprises steps which consist in: preparing an unsaponifiable matter of avocado

then in subjecting the unsaponifiable matter of avocado to a step of molecular distillation using adjusted temperature and pressure means to obtain either a distillate comprising mainly furan lipids and polyhydroxylated fatty alcohols of avocado. Said method enables in particular to extract selectively furan lipids of avocado having a furan lipid content of more than 80 wt. %, even close to 98%.

Priority: FR19990011846 Applic. Date: 1999-09-22; WO2000FR02601 Applic. Date: 2000-09-20

Inventor: BROUTIN NICOLE [FR]; LEGRAND JACQUES [FR]; PICCIRILLI ANTOINE [FR]


Patent No.: US6582709B1  Issued: 24/Jun/2003

Title: Cream composition comprising Dead Sea Mud

Applicant/Assignee: DEAD SEA LABORATORIES LTD

Application No.: 09/869827   Filing Date: 15/Oct/2001

Abstract:

The preset invention relates to a pharmaceutical cream composition for topical application for the treatment of skin disorders and skin diseases, comprising 1-6 wt. % Dead Sea Mud as an active ingredient. Said composition is for use in treating skin disorders and skin diseases such as psoriasis, saborrehic dermatitis, xerosis, attopic dermatitis, eczema, diaper rush, skin burns of stage I and sensitive skin. Said cream composition is also for use as a leave-on cosmetic cream for beautifying and enhancing the skin appearance. In addition to Dead Sea Mud said composition comprises ingredients suitable for the preparation of cosmetic cream. Said cream can further comprises up to 4 wt % Dead Sea water.

Priority: IL19990127943 Applic. Date: 1999-01-07; WO2000IL00011 Applic. Date: 2000-01-06

Inventor: MAOR ZEEV [IL]; YEHUDA SHAUL [IL]; MAGDASSI SHLOMO [IL]; MESHULAM-SIMON GALIT [IL]; GAVRIELI YONA [IL]; GILAD ZIVN [IL]; EFRON DOV [IL]


Patent No.: US6582710B2  Issued: 24/Jun/2003

Title: Products for topical applications comprising oil bodies

Applicant/Assignee: SEMBIOSYS GENETICS INC

Application No.: 10/058125   Filing Date: 29/Jan/2002

Abstract:

The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Priority: US2000-577147 Applic. Date: 2000-05-24; US1999-448600 Applic. Date: 1999-11-24; US1998-084777 Applic. Date: 1998-05-27; US19970047753P Applic. Date: 1997-05-27; US19970047779P Applic. Date: 1997-05-27; US19980075863P Applic. Date: 1998-02-25; US19980075864P Applic. Date: 1998-02-25

Inventor: DECKERS HARM M [CA]; ROOIJEN GIJS VAN [CA]; BOOTHE JOSEPH [CA]; GOLL JANIS [CA]; MOLONEY MAURICE M [CA]


Patent No.: US6582730B2  Issued: 24/Jun/2003

Title: Natural fluorescent dye obtained from a marine invertebrate, compositions containing the said dye and their uses

Applicant/Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Application No.: 09/820654   Filing Date: 30/Mar/2001

Abstract:

The present invention discloses the process of extraction, purification and characterization of a fluorescent dye from a marine echinoderm Holothuria scabra, compositions containing the dye and various applications of the dye.

Priority: DE20011017303 Applic. Date: 2001-03-30; GB20010008103 Applic. Date: 2001-03-30; WO2001IN00082 Applic. Date: 2001-03-30

Inventor: GOSWAMI USHA [IN]; GANGULY ANUTOSH [IN]


Patent No.: US6582737B2  Issued: 24/Jun/2003

Title: PHARMACEUTICAL COMPOSITION CONTAINING TWO ACTIVE INGREDIENTS FOR SMOKING CESSATION

Applicant/Assignee: PEIRCE MANAGEMENT, LLC

Application No.: 09/962927   Filing Date: 25/Sep/2001

Abstract:

A kit to alleviate tobacco-smoking withdrawal symptoms in a patient is disclosed which comprises:(a) a therapeutically effective amount of nicotine, at least one active nicotine metabolite, a combination of nicotine and an active nicotine metabolite, or an azapirone, or a pharmaceutically acceptable salt thereof

(b) a transdermal delivery system consisting essentially of a bupropion base in a therapeutically effective amount

and(c) a packaging material surrounding (a) and (b).

Priority:

Inventor: HIRSH MARK [US]; MIDHA KAMAL K [BM]; JUNGINGER HANS E [US]


Patent No.: US6584349B1  Issued: 24/Jun/2003

Title: Low cost electrodes for an iontophoretic device

Applicant/Assignee: VYTERIS, INC

Application No.: 08/971458   Filing Date: 17/Nov/1997

Abstract:

The present invention claims an apparatus for transdermal delivery of medicaments, with novel electrode systems, which avoids burns caused by changes in pH or excessive current applied at the sight of delivery, which is low in cost and easy to manufacture. In the present invention, preferably, the anode of the electrode system is predominantly formed from a low-cost bulk base metal which includes a coating of a precious metal thereon. The cathode of the electrode system is preferably formed from an chemically inert material which is a poor electron condutor and is coated on a good electron conductive material which has poor chemical stability. The electrode system of the present invention is highly efficient, easy to manufacture and cost-effective.

Priority: US1995-536029 Applic. Date: 1995-09-29

Inventor: SAGE JR BURTON H [US]; DENUZZIO JOHN D [US]; BOCK C RANDOLPH [US]; HAYNES JOHN L [US]; REDDY VILAMBI [US]


Patent No.: US6585984B1  Issued: 01/Jul/2003

Title: Dual composition cosmetic product with a concentration sensitive and an incompatible active respectively placed within first and second compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/713939   Filing Date: 16/Nov/2000

Abstract:

A cosmetic product is provided packaged in a dispenser with separate first and second storage areas. The first of the areas contains a first cosmetic composition containing a first dermal active agent, preferably selected from keratolytic skin agents. Particularly preferred are alpha- and beta-hydroxy carboxylic acids as first dermal active placed in a composition having a pH from about 1 to about 5.5. The second area contains a second cosmetic composition with a second dermal agent incompatible with the first composition. Particularly preferred second dermal agents are retinoids, vitamins, enzymes and anti-oxidants. Most preferred is retinol. The dispenser allows transfer of the first and second compositions through an exit nozzle in a respective dispensing weight ratio of from about 30:1 to about 2:1.

Priority: US20000186907P Applic. Date: 2000-03-03

Inventor: SCOTT IAN RICHARD [US]; HAGUE JONATHAN DAVID [ID]; SURYO DWIWAHYU HARYO [ID]; SULISTYOWATI ENDAH [ID]; CHANDAR PREM [US]; WEINKAUF RONNI LYNN [US]


Patent No.: US6586403B1  Issued: 01/Jul/2003

Title: Treating allergic reactions and inflammatory responses with tri-and dipeptides

Applicant/Assignee: SALPEP BIOTECHNOLOGY, INC

Application No.: 09/620249   Filing Date: 20/Jul/2000

Abstract:

This invention relates to methods and compositions of tripeptides and dipeptides having anti-inflammatory activities that can be used for the treatment of allergic and inflammatory reactions. A peptide of the formula:orwherein X is selected from the group consisting of H and acetyl

R.sub. 1 is selected from the group consisting of D or L-phenylalanine

tyrosine

tryptophan

phenylglycine

Nor-methylphenylalanine

cyclohexylalanine

and norleucine

R.sub.2 is selected from the group consisting of D or L-glutamate

and aspartate

and in the case of peptide (II), R.sub.3 is selected from the group consisting of glycine

D or L-alanine

beta-alanine

valine

leucine

isoleucine

sarcosine

and gamma-aminobutyric acid or another aliphatic amino acid

and Y is selected from the group consisting of OH and NH.sub.2, but excluding the dipeptides H-L-Phe-L-Glu-OH, H-L-Trp-L-Glu-OH, H-D-Phe-D-Glu-OH and H-D-Trp-D-Glu-OH.

Priority:

Inventor: MATHISON RONALD [CA]; METWALLY ESSAM [CA]


Patent No.: US6586473B1  Issued: 01/Jul/2003

Title: Topical drug delivery composition and method

Applicant/Assignee: MEDICIS PHARMACEUTICAL CORPORATION

Application No.: 09/481813   Filing Date: 12/Jan/2000

Abstract:

A topical composition for delivering an effective amount of a pharmaceutically acceptable drug, including laureth-4, propylene glycol, dimethylsorbide, and a pharmaceutically acceptable diluent is described as an improved drug delivery composition. Further, a method of transepithelial delivery of a drug to a human by topical application to the skin of a human of a composition including laureth-4, propylene glycol, dimethylsorbide, a pharmaceutically acceptable diluent of water and ethanol and an effective amount of a pharmaceutically acceptable drug has beneficial delivery effects.

Priority: US1995-484548 Applic. Date: 1995-06-07; US1994-199989 Applic. Date: 1994-02-22; US1992-944020 Applic. Date: 1992-09-11; US1991-677375 Applic. Date: 1991-03-27; US1989-334511 Applic. Date: 1989-04-06

Inventor: NIGRA THOMAS P [US]; GANS EUGENE H [US]


Patent No.: US6586859B2  Issued: 01/Jul/2003

Title: Electroactive polymer animated devices

Applicant/Assignee: SRI INTERNATIONAL

Application No.: 09/828496   Filing Date: 04/Apr/2001

Abstract:

The present invention relates to animated devices that include one or more electroactive polymer transducers. When actuated by electrical energy, an electroactive polymer produces mechanical deflection in one or more directions. This deflection may be used to produce motion of a feature included in an animated device. Electroactive polymer transducers offer customizable shapes and deflections. Combining different ways to configure and constrain a polymer, different ways to arrange active areas on a single polymer, different animated device designs, and different polymer orientations, permits a broad range of animated devices that use an electroactive polymer transducer to produce motion. These animated devices find use in a wide range of animated device applications.

Priority: US20000194817P Applic. Date: 2000-04-05

Inventor: KORNBLUH ROY D [US]; PELRINE RONALD E [US]; GALLAGHER PAUL K [US]; ECKERLE JOSEPH S [US]; CZYZYK DONALD E [US]; SHASTRI SUBRAMANIAN VENKAT [US]; PEI QIBING [US]


Patent No.: US6589515B2  Issued: 08/Jul/2003

Title: Cosmetic compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 09/982150   Filing Date: 17/Oct/2001

Abstract:

A cosmetic composition, preferably an antiperspirant composition, in solid or soft-solid form has a continuous phase which contains a water-immiscible liquid carrier and also contains a structurant which is partially or fully esterified maltose of the formulae:which is the beta-anomer, and optionallywhich is the alpha-anomer

wherein each Z is independently hydrogen or an acyl group of the formula:where R denotes a hydrocarbyl group containing from 8 to 31 carbon atoms, with the proviso that not more than half of the Z groups are hydrogen,and the ratio of beta-anomer to alpha-anomer is from 65:35 to 100:0.

Priority: GB20000025439 Applic. Date: 2000-10-17

Inventor: FRANKLIN KEVIN RONALD [GB]; LASBISTES NICOLAS [GB]; WEBB NICHOLAS [GB]; WHITE MICHAEL STEPHEN [GB]


Patent No.: US6589520B1  Issued: 08/Jul/2003

Title: Treatment of psoriasis, allergies and auto-immune disorders of the skin with cis-6-hexadecenoic acid

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/445641   Filing Date: 17/Apr/2000

Abstract:

A method for the prophylaxes and treatment of psoriasis, allergies and auto-immune disorders of the skin, the treatment of sensitive skin, or a combination thereof, which comprises applying cis-6-hexadecenoic acid, or a salt or ester thereof.

Priority: DE19971024622 Applic. Date: 1997-06-11; WO1998EP01949 Applic. Date: 1998-04-03

Inventor: HOPPE UDO [DE]; JACOB JURGEN [DE]


Patent No.: US6589542B2  Issued: 08/Jul/2003

Title: Topical composition comprising a functionally alkylating cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/092141   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functionally alkylating bonding agent having the structurewhereinX represents a cosmetic benefit agent that may or may not be attached to a chemical linker

R is selected from the group consisting of COCH2Cl, COCH2Br, COCH2I, Cl, Br, I, N3, CH2OM', CH2OT', CH2OT'', sulfonic esters

and whereinM' isb) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010274057P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6589568B2  Issued: 08/Jul/2003

Title: Therapeutic body lotion containing alkali metal hypohalite

Applicant/Assignee: NURAD, INC

Application No.: 09/784214   Filing Date: 16/Feb/2001

Abstract:

A topically applied composition capable of treating subcutaneous tissue comprising an alkali metal hypohalite (AMH) (preferably, sodium hypochlorite) and a conventional skin lotion. The skin lotion serves both as a carrier and as an antidrying agent for the AMH. The AMH penetrates through the skin's pores and lymph nodes into the subcutaneous tissue. The AMH stimulates the immune system to alleviate, and sometimes cure, inflammation, aches, pains, and other symptoms caused by microbial (e.g., viral, bacterial, fungal and parasitic) infection, arthritis, hemorrhoids, allergies, etc.

Priority:

Inventor: CAMPER JURDON WAYNE [US]; DELORME MARILYN A [US]; FESTVOG JOHN E [US]


Patent No.: US6589975B2  Issued: 08/Jul/2003

Title: Synthetic compounds for treatment of inflammation

Applicant/Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA HARBOR BRANCH OCEANOGRAPHIC INST

Application No.: 10/211370   Filing Date: 05/Aug/2002

Abstract:

Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

Priority: US2001-916470 Applic. Date: 2001-07-27; US1999-349316 Applic. Date: 1999-07-08; US19980091991P Applic. Date: 1998-07-08

Inventor: JACOBS ROBERT S [US]; MOYA CLAUDIA E [US]; WRIGHT AMY E [US]


Patent No.: US6589977B1  Issued: 08/Jul/2003

Title: Pyrrole derivatives and cell death inhibitors

Applicant/Assignee: SAGAMI CHEMICAL RESEARCH CENTER

Application No.: 09/890827   Filing Date: 06/Aug/2001

Abstract:

Bisindolylpyrrole derivatives represented by general formula [I] which are useful in inhibiting cell death and expected as being useful as preventives and remedies for the progress of various diseases in the progress and worsening of which cell death participates

and cell death inhibitors, drugs and cell/tissue/organ preservatives containing as the active ingredient these derivatives or pharmaceutically acceptable salts thereof.

Priority: JP19990031036 Applic. Date: 1999-02-09; WO2000JP00675 Applic. Date: 2000-02-08

Inventor: SODEOKA MIKIKO [JP]; KATOH MIHO [JP]; FUJITA MIKAKO [JP]; ASAKAI REI [JP]


Patent No.: US6592893B1  Issued: 15/Jul/2003

Title: Transdermal patch and topical compositions comprising propylnorapomorphine

Applicant/Assignee: UNIHART CORPORATION

Application No.: 09/743576   Filing Date: 12/Jan/2001

Abstract:

A pharmaceutical composition is characterized by: an active principle selected from one or more components of the group consisting of R(-)-propylnorapomorphine hydrochloride, S(+)-propylnorapomorphine hydrochloride, derivatives of R(-)-propylnorapomorphine hydrochloride and derivatives of S(+)-propylnorapomorphine hydrochloride, in pharmaceutically acceptable and effective doses, and further comprising components selected from the group consisting of stabilizers, solubilizers and permeation activators to facilitate the passage of the active principle through the skin. A transdermal patch that includes the pharmaceutical composition is also disclosed as well as a method of treatment for Parkinson's disease, hemicrania, sexual impotence, and psychotic disorders using the pharmaceutical composition or a transdermal patch that includes the pharmaceutical composition are described.

Priority: WO1999IE00066 Applic. Date: 1999-07-15; IT1998RM00479 Applic. Date: 1998-07-17

Inventor: GESSA GIAN LUIGI [IT]


Patent No.: US6592898B2  Issued: 15/Jul/2003

Title: Bioadhesive compositions comprising hydrophobic polymers

Applicant/Assignee: FIRST WATER LIMITED

Application No.: 09/771004   Filing Date: 26/Jan/2001

Abstract:

Bioadhesive compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive are described

and biomedical electrodes, fixation products and wound dressings containing them.

Priority: GB19980016826 Applic. Date: 1998-07-31; GB19990006700 Applic. Date: 1999-03-24; GB19990009348 Applic. Date: 1999-04-23; WO1999GB02516 Applic. Date: 1999-07-30

Inventor: MUNRO HUGH SEMPLE [GB]; YASIN MOHAMMED [GB]


Patent No.: US6593292B1  Issued: 15/Jul/2003

Title: Compositions and methods for enhancing drug delivery across and into epithelial tissues

Applicant/Assignee: CELLGATE, INC

Application No.: 09/648400   Filing Date: 24/Aug/2000

Abstract:

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.

Priority: US19990150510P Applic. Date: 1999-08-24

Inventor: ROTHBARD JONATHAN B [US]; WENDER PAUL A [US]; MCGRANE P LEO [US]; SISTA LALITHA V S [US]; KIRSCHBERG THORSTEN A [US]


Patent No.: US6593370B2  Issued: 15/Jul/2003

Title: TOPICAL CAPSAICIN PREPARATION

Applicant/Assignee: MARUISHI PHARMACEUTICAL CO., LTD

Application No.: 09/438978   Filing Date: 12/Nov/1999

Abstract:

A topical capsaicin preparation for the treatment of painful cutaneous disorders and neural dysfunction is disclosed. The preparation contains a nonionic, amphoteric or cationic surfactant in an amount effective to eliminate or substantially ameliorate burning pain caused by capsaicin.

Priority: JP19980341125 Applic. Date: 1998-11-13

Inventor: TAMURA TAKASHI [JP]; KAWAKAMI URAO [JP]; TERATANI YUICHI [JP]; YOSHIMURA MASAKAZU [JP]; SETO MASAHIKO [JP]


Patent No.: US6596287B2  Issued: 22/Jul/2003

Title: Products for topical applications comprising oil bodies

Applicant/Assignee: SEMIBIOSYS GENETICS INC

Application No.: 09/983540   Filing Date: 24/Oct/2001

Abstract:

The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Priority: US2000-577147 Applic. Date: 2000-05-24; US1999-448600 Applic. Date: 1999-11-24; US1998-084777 Applic. Date: 1998-05-27; US19980075863P Applic. Date: 1998-02-25; US19980075864P Applic. Date: 1998-02-25; US19970047779P Applic. Date: 1997-05-27; US19970047753P Applic. Date: 1997-05-27

Inventor: DECKERS HARM M [CA]; ROOIJEN GIJS VAN [CA]; BOOTHE JOSEPH [CA]; GOLL JANIS [CA]; MOLONEY MAURICE M [CA]


Patent No.: US6596289B1  Issued: 22/Jul/2003

Title: Anti-cellulite pantyhose

Applicant/Assignee:

Application No.: 09/627909   Filing Date: 27/Jul/2000

Abstract:

A garment for treating the skin, a method of making the garment and a method of using the garment to treat the skin, made of garment material, in particular hose material to be worn tightly against the skin, which has a multiplicity of durable chemical bonding sites. The durable sites which are preferably of the type to make covalent bonds, are bound to binding molecules which form chemical hooks for the garment material. Each of the chemical hooks has one or more semi-durable chemical bonding sites of the type which can chemically bond an active ingredient molecule to the binding agent but which is broken in the presence of skin conditions which are normal such as normal skin pH, normal skin moisture and normal skin heat generated both by body heat and the heat of friction of the garment rubbing against the skin. Active ingredient molecules such as molecules of theophylline or theophylline complexes are bound to the binding agent and are released to the skin when the garment is worn.

Priority: US1998-035315 Applic. Date: 1998-03-05

Inventor: PUGLIESE PETER T [US]


Patent No.: US6596763B1  Issued: 22/Jul/2003

Title: Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections

Applicant/Assignee: LIPOMEDICA EHF

Application No.: 09/297921   Filing Date: 16/Dec/1999

Abstract:

The present invention relates to a method for counteracting infections caused by bacteria, fungi or virus such as Herpes Simplex Virus in skin or mucosal membranes, in particular genital membranes, of a mammal. The method comprises topically administering to the skin or mucosal membrane an effective amount of a formulation comprising a) at least one microbicidal lipid, b) at least one solubilizing agent which keeps the lipid dissolved in the formulation, and optionally 3) a gel-forming agent. The formulation used in the method may suitable be in the form of a hydrogel. The microbicidal lipid is preferably a C6-18 fatty acid, such as, e.g., lauric acid, or a derivative thereof, e.g., a monoglyceride such as capric acid 1-monoglyceride. The solubilizing agent may suitably be a glycofurol such as the commercially-available glycofurol 75. The invention also relates to novel pharmaceutical formulations for use in the method.

Priority: WO1997DK00524 Applic. Date: 1997-11-14; IS19960004386 Applic. Date: 1996-11-14

Inventor: THORMAR HALLDOR [IS]; KRISTMUNDSDOTTIR THORDIS [IS]


Patent No.: US6599512B1  Issued: 29/Jul/2003

Title: Electrolyte content w/o emulsions for treating irritated/sensitive skins

Applicant/Assignee: LA ROCHE POSAY-LABORATOIRE PHARMACEUTIQUE

Application No.: 08/943191   Filing Date: 03/Oct/1997

Abstract:

Stable, topically applicable water-in-oil emulsions, well suited for therapeutically treating irritated/sensitive skins and having high electrolyte content, comprise (a) at least 26 by weight of at least one water-soluble metal salt, (b) at least one hydrophobic gelling agent, (c) less than 5% by weight of at least one emulsifying agent, and, advantageously, at least one biologically active agent, for example an active agent that modulates skin differentiation and/or proliferation and/or pigmentation, an anti-inflammatory, an antibacterial, an antifungal, etc., and/or at least one keratolytic active agent, neuropeptide antagonist and/or inflammation-mediator antagonist.

Priority: FR19960012196 Applic. Date: 1996-10-07

Inventor: BURNIER VERONIQUE [FR]


Patent No.: US6599513B2  Issued: 29/Jul/2003

Title: Products for topical applications comprising oil bodies

Applicant/Assignee: SEMBIOSYS GENETICS INC

Application No.: 09/983546   Filing Date: 24/Oct/2001

Abstract:

The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Priority: US2000-577147 Applic. Date: 2000-05-24; US1999-448600 Applic. Date: 1999-11-24; US1998-084777 Applic. Date: 1998-05-27; US19980075863P Applic. Date: 1998-02-25; US19980075864P Applic. Date: 1998-02-25; US19970047779P Applic. Date: 1997-05-27; US19970047753P Applic. Date: 1997-05-27

Inventor: DECKERS HARM M [CA]; ROOIJEN GIJS VAN [CA]; BOOTHE JOSEPH [CA]; GOLL JANIS [CA]; MOLONEY MAURICE M [CA]


Patent No.: US6599525B2  Issued: 29/Jul/2003

Title: Dressings and bandages comprising same

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 10/200843   Filing Date: 22/Jul/2002

Abstract:

The dressings of the invention comprise at least two components: an absorbent substrate having a first skin-facing surface and a second opposing surface

and a discontinuous coating of a semi-solid composition having an ointment-like feel overlying a portion of the first surface of said absorbent substrate. The absorbent substrate is useful as a passive dispenser of at least one active ingredient that may be contained therein. The discontinuous coating is essentially non-adherent to the skin and is useful as an active dispenser of at least one active ingredient that may be contained therein. In preferred embodiments the dressing of the invention contains at least one and more preferably at least two active ingredients intended to provide therapeutic benefit to the skin.

Priority: US2000-752023 Applic. Date: 2000-12-28; US2000-608412 Applic. Date: 2000-06-30; US1998-199142 Applic. Date: 1998-11-24

Inventor: SCAMILLA ALEDO MARIA APARECIDA [BR]; MEIZANIS JAMES J [US]; DE OLIVEIRA D ARTAGNAN SILVA [BR]; RANGEL FABIO EDUARDO FRANCA [BR]


Patent No.: US6599537B1  Issued: 29/Jul/2003

Title: Use of at least one extract of a plant of the genus Lannea in a cosmetic or dermopharmaceutical composition

Applicant/Assignee: COGNIS FRANCE S.A

Application No.: 10/031720   Filing Date: 17/Apr/2002

Abstract:

A cosmetic composition containing at least one plant extract from a plant belonging to a genus selected from the group consisting of Lannea, Odina, and mixtures thereof, for application onto a human substrate selected from the group consisting of skin, mucous membranes and epithelial appendages.

Priority: WO2000EP06696 Applic. Date: 2000-07-13; FR19990009428 Applic. Date: 1999-07-19

Inventor: PAULY GILLES [FR]; MOSER PHILIPPE [FR]; DANOUX LOUIS [FR]


Patent No.: US6605290B2  Issued: 12/Aug/2003

Title: Aerated composition, process for its manufacture and its use

Applicant/Assignee: L'OREAL

Application No.: 09/842169   Filing Date: 26/Apr/2001

Abstract:

An aerated composition comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase, characterized in that it contains air or inert gas in a sufficient amount to have a relative density ranging from 0.2 to 0.8 and in that it comprises at least one amphiphilic polymer and at least one anionic surfactant. The composition exhibits a very fine texture and good cosmetic properties, while remaining very stable over time. In particular, it can constitute a cosmetic composition intended especially for treating and/or cleansing the skin, including the scalp, nails and/or hair and for making up the skin.

Priority: FR19990004968 Applic. Date: 1999-04-20; US2000-553412 Applic. Date: 2000-04-20

Inventor: ROULIER VERONIQUE [FR]; DAUBIG THERESE [FR]


Patent No.: US6607713B1  Issued: 19/Aug/2003

Title: Method for improving UV radiation stability of photosensitive sunscreen filters

Applicant/Assignee: L'OREAL

Application No.: 09/857280   Filing Date: 21/Aug/2001

Abstract:

The invention relates to a process for improving the stability with respect to UV radiation of a photosensitive sunscreen agent, comprising the incorporation of said screening agent in a material prepared by the sol-gel route from at least one silicon alkoxide and from at least one surfactant. It is also targeted at a photostable material which comprises the combination of a photosensitive sunscreen agent and of a photostabilizing material prepared by the sol-gel route including at least one silicon alkoxide and at least one nonionic surfactant and at a cosmetic and/or dermatological composition comprising, in a cosmetically and/or dermatologically acceptable vehicle, an effective amount of a photostable material. This cosmetic and/or dermatological composition is intended mainly for protecting the skin and/or keratinous substances against ultraviolet radiation.

Priority: FR19990012320 Applic. Date: 1999-10-01; WO2000FR02688 Applic. Date: 2000-09-28

Inventor: CHODOROWSKI SANDRINE [FR]; QUINN FRANCIS XAVIER [FR]; SANCHEZ CLEMENT [FR]


Patent No.: US6607737B2  Issued: 19/Aug/2003

Title: Topical composition comprising an activated, trans-structured cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/158507   Filing Date: 30/May/2002

Abstract:

The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising trans structurewherein X represents a cosmetic benefit agent, L represents an optional chemical linker between X and a remainder of the bonding agent

and R represents an activating electron withdrawing group

and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010294429P Applic. Date: 2001-05-30

Inventor: BEKELE HAIMANOT [US]; MOTLEY CURTIS BOBBY [US]; MORRISSEY CHRISTOPHER TODD [US]


Patent No.: US6610311B2  Issued: 26/Aug/2003

Title: Packaged cosmetic effervescent cleansing pillow

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/855108   Filing Date: 14/May/2001

Abstract:

A packaged effervescent product is provided which includes a sachet surrounded by an outer package film sealing the sachet against water vapor transmission. The sachet is a cosmetic article which includes an effervescent cleansing composition of an acid material such as citric add and an alkaline material such as sodium bicarbonate. The composition is held within the sealed sachet or pouch. At least one wall of the pouch is water permeable. The outer package film is formed of a material which must have a breathability for carbon dioxide. Any carbon dioxide generated during storage is thereby allowed to slowly diffuse into the atmosphere while still minimizing the amount of water which may enter the package.

Priority: US20000224684P Applic. Date: 2000-08-11

Inventor: CHARAMBURA NATALIE [US]; BERGQUIST PAUL ROLAND [US]; SLAVTCHEFF CRAIG STEPHEN [US]


Patent No.: US6610312B2  Issued: 26/Aug/2003

Title: Cosmetic effervescent cleansing pillow

Applicant/Assignee: CHESEBROUGH-POND'S CO., DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/783777   Filing Date: 15/Feb/2001

Abstract:

A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.

Priority: US2000-532767 Applic. Date: 2000-03-22; US1998-130981 Applic. Date: 1998-08-07

Inventor: FARRELL LINDA [US]; SLAVTCHEFF CRAIG STEPHEN [US]; ZNAIDEN ALEXANDER PAUL [US]; VINSKI PAUL [US]


Patent No.: US6610322B1  Issued: 26/Aug/2003

Title: Self forming, thermodynamically stable liposomes and their applications

Applicant/Assignee:

Application No.: 09/745292   Filing Date: 20/Dec/2000

Abstract:

A liposome suspension forms spontaneously upon adding a diacylglycerol-PEG lipid to an aqueous solution when the lipid has appropriate packing parameters and the adding occurs above the melting temperature of the lipid. Combinations of lipids may be used in the invention. The liposome suspensions are useful for a variety of purposes, including delivery of theraputic agents.

Priority:

Inventor: KELLER BRIAN CHARLES [US]; LASIC DAN D [US]


Patent No.: US6610716B2  Issued: 26/Aug/2003

Title: Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging

Applicant/Assignee: ALTEON INCORPORATED

Application No.: 09/905035   Filing Date: 13/Jul/2001

Abstract:

Provided, among other things, is a compound of the formula:

Priority: US20000218273P Applic. Date: 2000-07-13; US20010296435P Applic. Date: 2001-06-06; US20010259242P Applic. Date: 2001-01-02; US20000259431P Applic. Date: 2000-12-29

Inventor: WAGLE DILIP R [US]; FANG SHENG DING [US]


Patent No.: US6613312B2  Issued: 02/Sep/2003

Title: Antiperspirant products made from wet-milled anhydrous antiperspirant salts

Applicant/Assignee: HELENE CURTIS UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/999612   Filing Date: 24/Oct/2001

Abstract:

Antiperspirant compositions which comprise:a) a wet-milled antiperspirant active material

b) a silicone and/or hydrocarbon carrier material

andc) a suspending agent or gellantare described.

Priority: US20000243203P Applic. Date: 2000-10-25

Inventor: RIZVI RIAZ HASSAN [US]; MOEN JENKS REBECCA SUE [US]


Patent No.: US6613341B2  Issued: 02/Sep/2003

Title: Topical composition comprising a substituted cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/158506   Filing Date: 30/May/2002

Abstract:

The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising the structurewherein X represents a cosmetic benefit agent

L represents an optional chemical linker

and R represents a hydrocarbon chain that optionally contains heteroatoms

and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to a mammalian proteinaceous substrate and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010294275P Applic. Date: 2001-05-30

Inventor: MOTLEY CURTIS BOBBY [US]; MORRISSEY CHRISTOPHER TODD [US]; BEKELE HAIMANOT [US]


Patent No.: US6616918B2  Issued: 09/Sep/2003

Title: Self-tanning composition containing an N-acyl amino acid ester and a self-tanning agent

Applicant/Assignee: L' OREAL L'OREAL

Application No.: 10/197252   Filing Date: 18/Jul/2002

Abstract:

The invention relates to cosmetic and/or dermatological compositions more particularly intended for artificially tanning and/or browning the skin, comprising, in a cosmetically acceptable support, at least one self-tanning agent and at least one N-acyl amino acid ester. The invention also relates to a cosmetic treatment process for artificially tanning and/or browning the skin, comprising applying to the skin an effective amount of the cosmetic and/or dermatological composition. The invention also relates to the use of an N-acyl amino acid ester with the aim of improving the coloration and/or stability of a self-tanning agent in a composition for artificially tanning and/or browning the skin.

Priority: FR20010009673 Applic. Date: 2001-07-19

Inventor: CANDAU DIDIER [FR]


Patent No.: US6616919B2  Issued: 09/Sep/2003

Title: Dibenzoylmethane sunscreen compositions containing photostabilizing amounts of tri-substituted butane compounds

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/228304   Filing Date: 27/Aug/2002

Abstract:

Improvedly photostable UV-photoprotecting cosmetic/dermatological compositions for the skin and/or the hair contain (a) a UV-photoprotective amount of at least one dibenzoylmethane sunscreen, e.g., 4-(tert-butyl)-4'-methoxydibenzoylmethane or 4-isopropyldibenzoylmethane, advantageously (a') a UV-photoprotective amount of at least one 1,3,5-triazine sunscreen, e.g., 2-[(p-(tert-butylamido]-4,6-bis[(p-(2'ethylhexyl-1'-oxycarbonyl)anilino]-1,3,5-triazine or 2,4,6-tris[p-(2'-ethylhexyl-1'-oxycarbonyl)anilino]-1,3,5-triazine, (b) an effective sunscreen photostabilizing amount of 1,1,1-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, formulated into (c) a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010011139 Applic. Date: 2001-08-27

Inventor: CANDAU DIDIER [FR]; AUBERT FABIEN [FR]


Patent No.: US6620409B2  Issued: 16/Sep/2003

Title: Hair and skin care agents

Applicant/Assignee: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

Application No.: 10/178177   Filing Date: 24/Jun/2002

Abstract:

Cosmetic skin or hair compositions are provided comprising a combination of (A) a dialkyl carbonate of the formula R1OC(O)OR2 wherein R1 and R2 are a linear or branched C6-22 alkyl group and (B) an aminoalkyl amide of the formula R3CONH(CH2)n-NR4R5 wherein R3CO is a linear C6-22 acyl group, R4 and R5 are selected from the group consisting of alkyl, hydroxyalkyl and aminoalkyl groups containing up to 6 carbon atoms or R4 and R5 together with the N atom form a 5- or 6-membered ring and n is a number from 2 to 6.

Priority: DE19991062877 Applic. Date: 1999-12-24; WO2000EP12817 Applic. Date: 2000-12-15

Inventor: BOSSMANN BRITTA [DE]; BERNECKER ULLRICH [DE]; HOLLENBERG DETLEF [DE]


Patent No.: US6620419B1  Issued: 16/Sep/2003

Title: Cosmetic or dermopharmaceutical use of peptides for healing, hydrating and improving skin appearance during natural or induced ageing (heliodermia, pollution)

Applicant/Assignee: SEDERMA

Application No.: 09/787175   Filing Date: 15/Mar/2001

Abstract:

The invention concerns the use of peptides of general sequence X-Thr-Thr-Lys-Y, wherein in particular X=lysine and Y=serine, in cosmetic or dermopharmaceutical compositions. It is moreover advantageous to use said peptides in mutual combination. In order to enhance their activity and their stability, the peptides are chemically modified to increase their lipophilicity, by grafting on the N-terminal amine of X, either a fatty acid chain, or by esterification or amidation of the C-terminal carboxyl group of Y. The peptides can be obtained by synthesis, biotechnology or controlled hydrolysis or plant proteins. The resulting compositions are advantageously used for stimulating healing, hydrating or all skin treatments. They are particularly active against formation or deterioration of wrinkles and against all the consequences of skin ageing, whether natural or induced (heliodermia, pollution), as well as for dry skin.

Priority: FR19980011533 Applic. Date: 1998-09-15; WO1999FR02178 Applic. Date: 1999-09-13

Inventor: LINTNER KARL [FR]


Patent No.: US6620429B1  Issued: 16/Sep/2003

Title: Use of basic alkali metal salts for manufacturing transdermal therapeutic system

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/647688   Filing Date: 30/Jul/2001

Abstract:

A process for manufacturing transdermal systems comprising free active substance bases is characterized in that the free active substance base is liberated, during the manufacture of the system, from active substance salts by conversion with a basic alkaline metal salt.

Priority: DE19981014083 Applic. Date: 1998-03-30; WO1999EP01876 Applic. Date: 1999-03-20

Inventor: MUELLER WALTER [DE]


Patent No.: US6620773B1  Issued: 16/Sep/2003

Title: Foaming oil preparation and its use

Applicant/Assignee: JOHNSON & JOHNSON GMBH

Application No.: 09/762177   Filing Date: 27/Apr/2001

Abstract:

The present invention relates to a composition which comprises at least a surfactant mixture and an oil component, the surfactant mixture comprising at least an anionic or zwitterionic surfactant, a nonionic surfactant and an alkyl phosphate component. The composition according to the invention is extremely well tolerated by the skin, mucosa and eyes, and has excellent foam formation.

Priority: DE19981035239 Applic. Date: 1998-08-04; WO1999EP05627 Applic. Date: 1999-08-03

Inventor: STORK ANJA [DE]; STETTEN OTTO VON [DE]


Patent No.: US6620854B2  Issued: 16/Sep/2003

Title: Surface-active preparations

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 09/885346   Filing Date: 19/Jun/2001

Abstract:

There are described surface-active soap compositions containing(a) from 0.01 to 2% by weight of an antimicrobial active ingredient from the class of diphenyl ethers,(b) from 0.1 to 30% by weight of a hydrotropic agent,(c) from 6.0 to 50% by weight of one or more synthetic detergents or soaps or a combination of such substances,(d) from 0 to 70% by weight of a monohydric or dihydric alcohol, and(e) tap water or deionised water ad 100%.The composition is used for disinfecting and cleaning human skin and hands and hard objects, and in washing and cleaning formulations for textile fibre materials.

Priority: EP20000810544 Applic. Date: 2000-06-21

Inventor: SCHNYDER MARCEL [CH]; BRUGGER FRANCOIS [FR]; HOFFSTETTER FERNAND [FR]; MUEHLBAUER KARIN [DE]; PETZOLD KARIN [DE]; VUKOMANOVIC RADOJKA [CH]


Patent No.: US6623751B2  Issued: 23/Sep/2003

Title: COSMETIC, PHARMACEUTICAL, OR DERMATOLOGICAL PATCH

Applicant/Assignee: L'OREAL L'OREAL S.A

Application No.: 09/362680   Filing Date: 29/Jul/1999

Abstract:

A cosmetic, pharmaceutical, or dermatological patch includes a composition including a hydrophilic gelling system in an aqueous phase. The hydrophilic gelling system includes at least one gellan gum and at least one other hydrocolloid.

Priority: FR19980009794 Applic. Date: 1998-07-30; FR19980009795 Applic. Date: 1998-07-30; FR19980009880 Applic. Date: 1998-07-31

Inventor: GUERET JEAN-LOUIS H [FR]


Patent No.: US6624199B1  Issued: 23/Sep/2003

Title: Aminobenzophenones

Applicant/Assignee: LEO PHARMACEUTICALS PRODUCTS LTD. A/S

Application No.: 10/030965   Filing Date: 22/Feb/2002

Abstract:

The present invention relates to compounds of formula Iwherein R1 represents one or more, similar or different substituents

R2 represents hydrogen, hydroxy, halogen, alkyl, alkoxy, alkylthio, or cyano

R3 represents one or more, similar or different substituents

and R6 represents hydrogen or methyl

and salts thereof with pharmaceutically acceptable acids, hydrates, and solvates, and to the use of compounds of the general formula IIin which formula R1 and R2 independently represent one or more, similar or different substituents

R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, phenyl, cyano, carboxy, or carbamoyl

R4, R5 and R6 represent independently hydrogen, trifluoromethyl, alkyl, carbamoyl, alkoxycarbonyl, or alkaloyl

x represents oxygen, N-OH, and N-O-alkyl, dialkoxy, cyclic dialkoxy, dialkylthio, or cyclic dialkylthio, and salts thereof with pharmaceutically acceptable, non-toxic acids.

Priority: WO2000DK00384 Applic. Date: 2000-07-11; US19990144065P Applic. Date: 1999-07-16

Inventor: OTTOSEN ERIK RYTTER [DK]; BJOERKLING FREDRIK [SE]


Patent No.: US6627179B2  Issued: 30/Sep/2003

Title: SYNERGISTICALLY UV-PHOTOPROTECTING MIXED SUNSCREEN COMPOSITIONS

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/314182   Filing Date: 09/Dec/2002

Abstract:

Topically applicable cosmetic/dermatological sunscreen composition well suited for the enhanced UV-photoprotection of human skin and/or hair, contain synergistically UV-APPD-enhancing amounts of (i) at least one UV-screening silicon compound having a benzotriazole functional group substituent, (ii) at least one UV-screening dibenzoylmethane compound, and (iii) at least one UV-screening amino-substituted 2-hydroxybenzophenone compound having the following structural formula (III):formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010015857 Applic. Date: 2001-12-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6627180B2  Issued: 30/Sep/2003

Title: SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/314195   Filing Date: 09/Dec/2002

Abstract:

Topically applicable cosmetic/dermatological sunscreen compositions well suited for the enhanced UV-photoprotection of human skin and/or hair contain synergistically UV-APPD-enhancing amounts of (a) particulates of at least one insoluble organic UV-screening agent having a particle size ranging from 10 nm to 5 mum, and (b) at least one UV-screening amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I):formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010015860 Applic. Date: 2001-12-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6627192B1  Issued: 30/Sep/2003

Title: Use of dual compartment mixing container for enzyme mixtures useful to treat acne

Applicant/Assignee:

Application No.: 09/673511   Filing Date: 16/Feb/2001

Abstract:

An enzymatic powder (or tablet) is stored in a compartment contained in the closure of a vial. The powder contains enzymes from the enzymatic categories Lipases, Peptidases, Keratinases. The vial contains a buffer solution in which the enzymes will be mixed. By pressing the top of the closure, its bottom side breaks and the powder (or tablet) falls into the vial's buffer solution. Thus, an enzymatic cosmetic product is made just before its required application. By selecting these enzymatic categories and their applications fat, proteinic remnants (dead cells) and keratinic molecules can be removed so a deep skin enzymatic cleaning can be achieved. In addition, these enzymatic mixtures can open blocked sebaceous glands by dissolving sebum, dead cells and keratines that clog them. By doing so acneic symptoms diminish dramatically and sebaceous glands return to their normal function. This product proved very adjuvant in acneic therapy, since it can also be combined with antibiotic therapy given by dermatologists.

Priority: GR19970100459 Applic. Date: 1997-11-21; WO1998GR00033 Applic. Date: 1998-11-20

Inventor: TSAKAS SPYROS [GR]


Patent No.: US6627637B2  Issued: 30/Sep/2003

Title: Substituted beta carbolines

Applicant/Assignee: AVENTIS PHARMA DEUTSCHLAND GMBH

Application No.: 09/812785   Filing Date: 15/Mar/2001

Abstract:

The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I,which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of IkappaB kinase is involved.

Priority: EP20000105514 Applic. Date: 2000-03-15; EP20000125169 Applic. Date: 2000-11-18

Inventor: RITZELER OLAF [DE]; CASTRO ALFREDO [US]; GRENIER LOUIS [US]; SOUCY FRANCOIS [US]; HANCOCK WAYNE W [US]; MAZDIYASHI HORMOZ [US]; PALOMBELLA VITO [US]; ADAMS JULIAN [US]


Patent No.: US6627652B1  Issued: 30/Sep/2003

Title: Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors

Applicant/Assignee: ALLERGAN, INC

Application No.: 08/425558   Filing Date: 20/Apr/1995

Abstract:

Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid receptor sites in preference to the RAR retinoid receptor sites. A compound is defined to be a selective agonist of the RXR receptor site if the compound is at least approximately ten times more effective as an agonist in the RXR receptor sites than in the RAR receptor sites.

Priority: US1993-016404 Applic. Date: 1993-02-11

Inventor: CHANDRARATNA ROSHANTHA A S [US]


Patent No.: US6630131B2  Issued: 07/Oct/2003

Title: Composition containing a mixed silicate, a polysaccharide and crosslinked poly(2-acrylamido-2-methyl-propane-sulphonic acid) polymer

Applicant/Assignee: L'OREAL

Application No.: 09/985758   Filing Date: 06/Nov/2001

Abstract:

The invention relates to a composition containing at least one mixed silicate, at least one polysaccharide and at least one crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer which is at least 90% neutralized, having use in the cosmetic field as a tightening agent, in particular for tightening the skin and smoothing it so as to immediately attenuate the wrinkles and/or fine lines on the skin.

Priority: FR20000014175 Applic. Date: 2000-11-06

Inventor: CHEVALIER VERONIQUE [FR]; HUREL VALERIE [FR]


Patent No.: US6630149B1  Issued: 07/Oct/2003

Title: Blister containing a transdermal therapeutic system and a single dose form of administration

Applicant/Assignee: LTS LOHMANN THERAPIE SYSTEME AG

Application No.: 09/743540   Filing Date: 23/Mar/2001

Abstract:

A form of administration for medical active agents in the form of a blister is characterized in that it contains a transdermal therapeutic system and at least one single dose form of the active agent next to each other.

Priority: DE19981031263 Applic. Date: 1998-07-11; WO1999EP04614 Applic. Date: 1999-07-02

Inventor: SCHAEFER WOLFGANG [DE]; FRANKE HANSHERMANN [DE]; ASMUSSEN BODO [DE]


Patent No.: US6630158B2  Issued: 07/Oct/2003

Title: Dietary supplement composition and method for improving and maintaining healthy skin

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 10/003926   Filing Date: 30/Oct/2001

Abstract:

A dietary supplement composition for promoting healthy skin comprised of lycopene and other carotenoids, selenium, chromium and biotin.

Priority: US20000244635P Applic. Date: 2000-10-31

Inventor: POPP KARL F [US]; ALIOTO SAMUEL J [US]


Patent No.: US6630177B1  Issued: 07/Oct/2003

Title: Products extracted from a plant of the genus Commiphora, particularly the Commiphora mukul plant, extracts containing same and applications thereof, for example in cosmetics

Applicant/Assignee: PARFUMS CHRISTIAN DIOR

Application No.: 09/352939   Filing Date: 14/Jul/1999

Abstract:

Products of formula (I) extracted from a plant of the genus Commiphora, particularly the Commiphora mukul plant, wherein R is (a) a CH2OH grouping, (b) a COOH grouping, and salts or esters thereof are described. These products and the extracts containing them are effective cosmetic agents against wrinkles.

Priority: FR19950010710 Applic. Date: 1995-09-13

Inventor: ANDRE PATRICE [FR]; LHERMITE STEPHANE [FR]; PELLICIER FRANCOISE [FR]


Patent No.: US6630442B1  Issued: 07/Oct/2003

Title: Reparatives for chemosurgery and laser (thermal) therapy

Applicant/Assignee:

Application No.: 08/781868   Filing Date: 10/Jan/1997

Abstract:

A composition of glutathione and selenium, as a selenoamino acid or selenium yeast extract and an epidermal growth factor in a topical carrier and method of using the composition to reduce and repair skin damage, resulting from aesthetic (exfoliation and chemical peels) and surgical (laser and other therapies) procedures and other chemical and thermal burns to the cutaneous tissues.

Priority:

Inventor: HERSH THEODORE [US]


Patent No.: US6630516B2  Issued: 07/Oct/2003

Title: METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING CHRONOLOGICAL AGING IN HUMAN SKIN

Applicant/Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Application No.: 09/028435   Filing Date: 24/Feb/1998

Abstract:

The deleterious effects of the passage of time on human skin (i.e., chronological aging of human skin) can be prevented and treated with the topical application of a retinoid, preferably retinol. We have found that some of the same pathways (namely the stress-activated pathways, SAPs) activated in photoaging of human skin (i.e., sun-induced premature skin aging) are similarly elevated in the skin of elderly people. We have also found that other pathways (namely the mitogen-activated ERK pathway) is depressed in the same skin. Treatment of chronologically-aged skin with a non-retinoid MMP inhibitor and optionally a retinoid both inhibits degradation of dermal collagen and promotes procollagen synthesis.

Biopsied sections from skin of elderly (80+ years old) show that a single treatment can increase epidermal thickness, improve the dermal collagen density, and promote the formation of rete pegs and dermal papillae (see FIG. 13), and can decrease the amount of c-Jun and increase the amounts of Types I and III procollagen (see FIG. 18). Such benefits are also helpful in preventing bruising, tearing, and ulceration of elderly skin.

Priority: US19970040594P Applic. Date: 1997-02-25; US19970042976P Applic. Date: 1997-04-08

Inventor: VARANI JAMES [US]; FISHER GARY J [US]; VOORHEES JOHN J [US]; KANG SEWON [US]


Patent No.: US6632218B1  Issued: 14/Oct/2003

Title: Alexandrite laser system for hair removal and method therefor

Applicant/Assignee: CYNOSURE, INC

Application No.: 09/425156   Filing Date: 21/Oct/1999

Abstract:

A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm <2 . The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.

Priority: US1998-158056 Applic. Date: 1998-09-22; US1996-744344 Applic. Date: 1996-11-07

Inventor: FURUMOTO HORACE W [US]; CHO GEORGE [US]; MCDANIEL DAVID H [US]; KOSCHMANN ERIC [US]; RIZZO ANTONIO G [US]


Patent No.: US6632798B2  Issued: 14/Oct/2003

Title: Methods for inhibiting angiogenesis

Applicant/Assignee: ANTIGEN BIOLOGICALS CORPORATION

Application No.: 10/153003   Filing Date: 22/May/2002

Abstract:

Methods for inhibiting angiogenisis are disclosed the comprise administering oleouropein and/or the products of its hydrolysis in therapeutically effective amounts. The methods and compositions of the present invention are particularly effective in inhibiting the vascularization of endothelial cells, and may be utilized to treat a wide variety of cancers, ocular diseases, and inflammatory conditions.

Priority: US20010292947P Applic. Date: 2001-05-23

Inventor: HAMDI HAMDI K [US]; TAVIS JEFFREY H [US]; CASTELLON RAQUEL [US]


Patent No.: US6635285B2  Issued: 21/Oct/2003

Title: Shark cartilage extract: process of making, methods of using, and compositions thereof

Applicant/Assignee: AEETERNA LABORATORIES, INC LES LABORATOIRES AETERNA, INC

Application No.: 10/068950   Filing Date: 07/Feb/2002

Abstract:

The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis.

Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.

Priority: US2000-504065 Applic. Date: 2000-02-15; US1996-693535 Applic. Date: 1996-08-08; US1995-550003 Applic. Date: 1995-10-30; US1995-384555 Applic. Date: 1995-02-03; US1994-234019 Applic. Date: 1994-04-28

Inventor: DUPONT ERIC [CA]; BRAZEAU PAUL [CA]; JUNEAU CHRISTINA [CA]; MAES DANIEL H [US]; MARENUS KENNETH [US]; BELIVEAU RICHARD [CA]


Patent No.: US6635786B2  Issued: 21/Oct/2003

Title: Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use

Applicant/Assignee: GUILFORD PHARMACEUTICALS, INC

Application No.: 09/829827   Filing Date: 10/Apr/2001

Abstract:

Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

Priority: US20010261738P Applic. Date: 2001-01-16

Inventor: LI JIA-HE [US]; FERRARIS DANA VICTOR [US]; KLETZLY PAUL W [US]; LI WEIXING [US]; WANG ERIC YANJUN [US]; XING AMY D [US]; XU WEIZHENG [US]; ZHANG JIE [US]


Patent No.: US6638528B1  Issued: 28/Oct/2003

Title: Compositions and methods to effect the release profile in the transdermal administration of active agents

Applicant/Assignee: NOVEN PHARMACEUTICALS, INC

Application No.: 10/086457   Filing Date: 01/Mar/2002

Abstract:

Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

Priority: US2001-765932 Applic. Date: 2001-01-19; US20000177103P Applic. Date: 2000-01-20

Inventor: KANIOS DAVID [US]


Patent No.: US6638538B1  Issued: 28/Oct/2003

Title: Hyaluronic acid gel composition, process for producing the same, and medical material containing the same

Applicant/Assignee: DENKI KAGAKU KOGYO KABUSHIKI KAISHA

Application No.: 09/913718   Filing Date: 27/Sep/2001

Abstract:

A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37 DEG C.

Priority: JP19990042371 Applic. Date: 1999-02-19; JP19990318579 Applic. Date: 1999-11-09; WO2000JP00946 Applic. Date: 2000-02-18

Inventor: HASHIMOTO MASAMICHI [JP]; UMEDA TOSHIHIKO [JP]; ARAI KAZUHIKO [JP]; MIYATA YOSHIAKI [JP]; YAMAMOTO OSAMU [JP]; HIMEDA YASUKAZU [JP]


Patent No.: US6638918B2  Issued: 28/Oct/2003

Title: Chitosan compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/280617   Filing Date: 25/Oct/2002

Abstract:

Compositions comprising chitosan in the form of a network of nano-sized fibres. There is also provided a process for making such compositions. The compositions have improved solubility and activity. The compositions are useful in hair care, skin care, odour control, wound care, blood management, sanitary compositions, oral care, film formation, hard surface treatment, fabric treatment, release of hydrophobic or hydrophilic materials, plant care, water purification and drug delivery.

Priority: GB20010026923 Applic. Date: 2001-11-09

Inventor: DAVISON GORDON ROBERT [GB]; KONIG AXEL [BE]; GIBBONS CLYDE [GB]; RIPLEY MARK BRIAN [GB]; MACGILP NEIL ARCHIBALD [GB]; MILICH GEORGINA LYNDSEY CLAIRE [GB]; PRETSWELL EMMA LOUISE [GB]


Patent No.: US6639014B2  Issued: 28/Oct/2003

Title: Multiblock biodegradable hydrogels for drug delivery and tissue treatment

Applicant/Assignee: FOCAL, INC

Application No.: 10/114722   Filing Date: 02/Apr/2002

Abstract:

Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Priority: US2000-710416 Applic. Date: 2000-11-09; US1996-692914 Applic. Date: 1996-07-26; US19950001723P Applic. Date: 1995-07-28

Inventor: PATHAK CHANDRASHEKHAR P [US]; BARMAN SHIKHA P [US]; PHILBROOK C MICHAEL [US]; SAWHNEY AMARPREET S [US]; COURY ARTHUR J [US]; AVILA LUIS Z [US]; KIERAS MARK T [US]


Patent No.: US6641802B2  Issued: 04/Nov/2003

Title: Amino acid compounds and photoprotecting compositions comprised thereof

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/026607   Filing Date: 27/Dec/2001

Abstract:

Amino acid compounds having the formula (I):are well suited for the UV-photoprotection of human skin and/or hair, as well as for the UV-photoprotection of a wide variety of photosensitive industrial materials/substrates, e.g., plastics, glasses, textiles, etc.

Priority: FR20000005393 Applic. Date: 2000-04-27; WO2001FR01137 Applic. Date: 2001-04-12

Inventor: BORDIER THIERRY [FR]; PHILIPPE MICHEL [FR]


Patent No.: US6645507B2  Issued: 11/Nov/2003

Title: SKIN PRODUCT HAVING CONTINUING ANTIMICROBIAL, ANTIVIRAL, ANTISEPTIC, AND HEALING PROPERTIES

Applicant/Assignee: AMERICAN MEDICAL RESEARCH, INC

Application No.: 09/331817   Filing Date: 25/Jun/1999

Abstract:

A composition capable of forming a film that ionically bonds to the skin comprising: one or more active agents

a nonionic or substantially nonionic first film forming component

one or more cationic surfactants comprising one or more fatty moieties that are soluble in the first film forming component

and a liquid carrier. Also provided are stable emulsions of such compositions, compositions that are especially adapted to delivering medicinal agents to the surface of the skin, and methods for preparing such compositions.

Priority: US19960033796P Applic. Date: 1996-12-31; WO1997US24220 Applic. Date: 1997-12-31

Inventor: BETTLE GRISCOM [US]; COURY WILLIAM S [US]; PETTERSSON BERNO I [US]


Patent No.: US6645510B1  Issued: 11/Nov/2003

Title: Method of treating topical ailments

Applicant/Assignee: AMERICAN MEDICAL RESEARCH, INC

Application No.: 09/787547   Filing Date: 30/Aug/2001

Abstract:

A composition capable of forming a film that ionically bonds to the skin comprising one or more active agents, a nonionic or substantially nonionic first film forming component, one or more cationic surfactant and a liquid carrier.

Priority: US19980091234P Applic. Date: 1998-06-30; WO1999US14907 Applic. Date: 1999-06-30

Inventor: COURY WILLIAM S [US]; BETTLE GRISCOM [US]; PETTERSSON BERNO I [US]


Patent No.: US6645512B2  Issued: 11/Nov/2003

Title: Topical composition comprising a functionally acylating cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/092329   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of an acylating bonding agent having the structure:wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and R represents N3, Cl, Br or OM wherein M is an activated ester

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273983P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6645942B1  Issued: 11/Nov/2003

Title: Somatic cell gene therapy

Applicant/Assignee: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

Application No.: 08/232452   Filing Date: 22/Apr/1994

Abstract:

The present invention is a somatic cell gene therapy method that is especially useful for the treatment of certain diseases that are caused by gene defects. According to the invention, fibroblast cells are transduced so that they express a "replacement" gene of interest. These transduced fibroblasts are preferably fixed in vitro in an extracellular matrix, and then implanted in the loose connective tissue of the skin of an individual or animal to be treated. Because the fibroblasts are implanted in a highly vascularized compartment of the skin i.e., loose connective tissue of the dermis, the transduced cells, and thus their "replacement" gene products, have direct access to the circulatory system. As a result the needed replacement gene products can easily and efficiently be distributed to other parts of the body. When the gene therapy is no longer needed, the implanted fibroblasts can be conveniently removed.

Priority: US1991-667169 Applic. Date: 1991-03-08; US1988-187214 Applic. Date: 1988-04-28

Inventor: VERMA INDER MOHAN [US]; ST LOUIS DANIEL CLAUDE [US]


Patent No.: US6649153B1  Issued: 18/Nov/2003

Title: Skin friendly antiperspirant composition and method of making

Applicant/Assignee: REHEIS INC

Application No.: 10/244701   Filing Date: 16/Sep/2002

Abstract:

An improved skin friendly antiperspirant is provided in which a suitable polyhydric alcohol e.g., glycerin, is complexed with the antiperspirant of the type of activated or nonactivated aluminum or aluminum/zirconium salt that are commonly considered antiperspirant active materials and are covered by FDA OTC Tentative Final Monograph as Category I. Suitable antiperspirant salts include (but are not limited to): aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex PG, aluminum dichlorohydrex PG, aluminum sesquichlorohydrex PG, aluminum chlorohydrex PEG, aluminum sesquichlorohydrex PEG, aluminum chloride (15 percent or less aqueous solutions), aluminum zirconium chlorohydrates, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium octachlorohydrate, aluminum zirconium trichlorohydrex Gly, aluminum zirconium penta chlorohydrex Gly, aluminum zirconium tetrachlorohydrex Gly, aluminum zirconium octachlorohydrex Gly, buffered aluminum sulfate, basic aluminum chlorides, zirconium hydroxychloride, zirconyl chloride, basic aluminum nitrates, basic aluminum chlorides combined with zirconyl oxychloride and/or hydroxychloride and organic complexes of each of basic aluminum chlorides with or without zirconyl chloride or zirconium hydroxychloride and mixture of any of the foregoing. Aluminum, zinc or zinc and zirconium complexes or aluminum, zinc and zirconium complexes with having metals/anion ratio of 0.9:1 to 2:1 where the anion is Cl, Br, I and/or NO, with or without additives such as amino acids or polyhydric alcohols.

Priority:

Inventor: PAREKH JAWAHAR C [US]; LI ZIJUN [US]


Patent No.: US6649178B2  Issued: 18/Nov/2003

Title: Cosmetic composition for stressed skin under extreme conditions

Applicant/Assignee:

Application No.: 09/880245   Filing Date: 13/Jun/2001

Abstract:

A cosmetic composition is provided effective against stresses of climate extremes. The composition includes hot, cold and dry climate treatment portions. The hot climate treatment portion has a first botanical ingredient to impart a cool sensation, and a sunscreen agent. The cold climate treatment portion has a second botanical ingredient to combat skin inflammation, and a silicone fluid or hydrocarbon for retaining moisturize. The dry climate treatment portion has a third botanical ingredient to impart moisturization and an ester.

Priority: US20000211290P Applic. Date: 2000-06-13

Inventor: MOHAMMADI FATEMEH [US]; VARGAS ANTHONY [US]


Patent No.: US6652843B2  Issued: 25/Nov/2003

Title: ANTIPERSPIRANT COMPOSITIONS

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 10/346676   Filing Date: 17/Jan/2003

Abstract:

Clear solid suspension antiperspirant compositions comprise 0.5 to 50% by weight of a particulate antiperspirant active material of which less than 50% by weight of its particles are below 110pm diameter and a refractive index of from 1.49 to 1.57 at 22 DEG C. is suspended in a water-immiscible carrier liquid of which at least 50% by weight is selected from liquid non-volatile silicone oils and liquid alkyl-aryl esters and not more than 25% by weight of the carrier liquid comprises a volatile silicone oil. The carrier liquid and the antiperspirant have refractive indexes which differ by no more than 0.02 at 22 DEG C and the structurant which solidifies the carrier liquid comprises a fibre-forming non-polymeric structurant, and preferably an N-acyl aminoacid amide such as GPl and/or a cyclodipeptide such as a thymol derivative of (2S-cis)-(-)-5-benzyl-3,6-dioxo-2-piperazine acetic acid.

Priority: GB20020001163 Applic. Date: 2002-01-18

Inventor: FAIRCLOUGH COLETTE MARIE [GB]; FRANKIN KEVIN RONALD [GB]


Patent No.: US6652876B2  Issued: 25/Nov/2003

Title: Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/745613   Filing Date: 21/Dec/2000

Abstract:

An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed ofa) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene,b) from 5 to 40% by weight of amorphous poly-alpha-olefin,c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 mum, andd) from 0.001 to 20% by weight of a drug.

Priority: DE20001003767 Applic. Date: 2000-01-28

Inventor: RADLOFF DETLEV [DE]; WASNER MATTHIAS [DE]


Patent No.: US6653091B1  Issued: 25/Nov/2003

Title: Method and device for predicting physiological values

Applicant/Assignee: CYGNUS, INC CYNGNUS, INC

Application No.: 09/911341   Filing Date: 23/Jul/2001

Abstract:

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

Priority: US1999-405976 Applic. Date: 1999-09-27; US1998-198039 Applic. Date: 1998-11-23; US1998-163856 Applic. Date: 1998-09-30; US1999-241929 Applic. Date: 1999-02-01

Inventor: DUNN TIMOTHY C [US]; JAYALAKSHMI YALIA [US]; KURNIK RONALD T [US]; LESHO MATTHEW J [US]; OLIVER JONATHAN JAMES [US]; POTTS RUSSELL O [US]; TAMADA JANET A [US]; WATERHOUSE STEVEN RICHARD [US]; WEI CHARLES W [US]


Patent No.: US6653317B2  Issued: 25/Nov/2003

Title: Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/301733   Filing Date: 22/Nov/2002

Abstract:

Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I):in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical -OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.

Priority: FR19980009509 Applic. Date: 1998-07-24; US2001-874053 Applic. Date: 2001-06-06; US1999-360495 Applic. Date: 1999-07-23

Inventor: MAHE YANN [FR]; MICHELET JEAN-FRANCOIS [FR]; PICHAUD PATRICK [FR]; GALEY JEAN-BAPTISTE [FR]


Patent No.: US6653326B1  Issued: 25/Nov/2003

Title: Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof

Applicant/Assignee: BIOREX RESEARCH & DEVELOPMENT CO

Application No.: 08/860582   Filing Date: 07/Dec/1999

Abstract:

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively

an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Priority: HU19950003141 Applic. Date: 1995-11-02; HU19960003919 Applic. Date: 1996-02-09; HU19960029820 Applic. Date: 1996-10-04; WO1996HU00064 Applic. Date: 1996-11-01

Inventor: VIGH LASZLO [HU]; NAGY PETER LITERATI [HU]; SZILBEREKY JENO [HU]; UEROEGDI LASZLO [HU]; JEDNAKOVITS ANDREA [HU]; JASZLITS LASZLO [HU]; BIRO KATALIN [HU]; MARVANYOS EDE [HU]; BARABAS MIHALY [HU]; HEGEDUES ERZSEBET [HU]; KORANYI LASZLO [HU]; KUERTHY MARIA [HU]; BALOGH GABOR [HU]; HORVATH IBOLYA [HU]; TOEROEK ZSOLT [HU]; UDVARDY EVA [HU]; DORMAN GYOERGY [HU]; MEDZIHRADSZKY DENES [HU]; MEZES BEA [HU]; KOVACS ESZTER [HU]; DUDA ERNOE [HU]; FARKAS BEATRIX [HU]; GLATZ ATTILA [HU]


Patent No.: US6656151B1  Issued: 02/Dec/2003

Title: Vascular access devices and systems

Applicant/Assignee: INTEGRATED VASCULAR INTERVENTIONAL TECHNOLOGIES, L.C. (IVIT, LC)

Application No.: 09/480964   Filing Date: 11/Jan/2000

Abstract:

Vascular access systems and devices for facilitating repeated access to a blood vessel. These systems and devices can be used in external treatment of blood, such as dialysis, and in intra-venous administration of medicines, such as heparin, for extended periods of time, while avoiding deleterious effects such as those derived from repeated puncturing of the blood vessel tissues or exposure of such tissues to abnormal fluid flows. The vascular access systems comprise an anastomosis graft vessel, an occlusal balloon, and a port device for accessing the occlusal balloon. Occlusal balloons can be self-contained, they can rely on osmosis, and they can serve as the support of an agent to which the blood stream is exposed, either by transport or by mere contact. In addition, occlusal balloons can adopt a distended and a collapsed configuration, the latter allowing for blood flow through the anastomosis graft vessel.

Priority:

Inventor: BLATTER DUANE D [US]


Patent No.: US6656487B2  Issued: 02/Dec/2003

Title: Composition containing fibers and a dispersing copolymer

Applicant/Assignee: L'OREAL

Application No.: 09/987877   Filing Date: 16/Nov/2001

Abstract:

The invention relates to a composition containing fibers and a copolymer comprising carboxylate groups and polydimethylsiloxane groups. The composition according to the invention may especially constitute a care or make-up composition for keratin materials such as the skin, including the scalp, the lips of the face and integuments, for instance the eyelashes, the eyebrows, the nails and the hair. The invention also relates to the use of a copolymer comprising carboxylate groups and polydimethylsiloxane groups in a composition containing fibers to ensure a homogeneous dispersion of the fibers in the composition and to stabilize the composition.

Priority: FR20000015741 Applic. Date: 2000-12-05

Inventor: AFRIAT ISABELLE [FR]; TOURNILHAC FLORENCE [FR]


Patent No.: US6656491B1  Issued: 02/Dec/2003

Title: Active substance plasters

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/719114   Filing Date: 07/Dec/2000

Abstract:

Active substance plasters consisting of a backing material and an at least partially applied adhesive composition, characterized in that a component comprising one or more active substances is additionally applied in the form of spun fibres or filaments to the backing material, this component having an at least partly thermoplastic basis.

Priority: DE19981025499 Applic. Date: 1998-06-08; WO1999EP03900 Applic. Date: 1999-06-05

Inventor: BROSCK KATHARINA [BR]; JAUCHEN PETER [DE]; KOEHLER ULRICH [DE]; HIMMELSBACH PETER [DE]; WASNER MATTHIAS [DE]


Patent No.: US6656701B2  Issued: 02/Dec/2003

Title: Combination of acid protease enzymes and acidic buffers and uses thereof

Applicant/Assignee: ACTIM ORGANICS, INC

Application No.: 10/059790   Filing Date: 29/Jan/2002

Abstract:

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5.

The acidic buffer comprises at least one acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes.

Such types of abnormal biological conditions, diseases or disorders include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

Priority: US1999-354687 Applic. Date: 1999-07-16; US1999-664056 Applic. Date: 1999-11-02

Inventor: BISHOP MICHAEL [US]; GILLIS GLEN [US]; NORTON SCOTT J [US]


Patent No.: US6660251B1  Issued: 09/Dec/2003

Title: Galenic formulation containing biotin

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 09/890294   Filing Date: 27/Jul/2001

Abstract:

The invention relates to galenic formulations which contain a) one or more compounds selected from biotin, its physiologically compatible salts, biotin esters and the steroisomeric forms of these compounds

and b) one or more compounds selected from urea and urea derivatives. The above formulations are suitable for use as topically administered formulations for the cosmetic and/or medical treatment of the skin, hair and/or nails.

Priority: DE19991003241 Applic. Date: 1999-01-28; WO2000EP00248 Applic. Date: 2000-01-14

Inventor: BUENGER JOACHIM [DE]; DRILLER HANSJUERGEN [DE]; WOHLRAB WOLFGANG [DE]; MOTITSCHKE LOTHAR [DE]; HUSCHKA CHRISTOPH [DE]; NEUBERT REINHARD [DE]


Patent No.: US6663659B2  Issued: 16/Dec/2003

Title: Method and apparatus for the photomodulation of living cells

Applicant/Assignee:

Application No.: 09/894899   Filing Date: 29/Jun/2001

Abstract:

The invention is a system and method for the photomodulation of living tissue. When photomodulated, living tissue will exhibit bioactivation or bioinhibition according to the present invention and, when using the disclosed sources of narrowband multichromatic radiation can cause significant dermatologic advantages such as hair removal, hair growth stimulation, wrinkle reduction, acne reduction and scar removal, vitiligo, etc. This invention may be applied to non-dermatological medical treatments including tumor growth inhibition, cell regeneration, the stimulation of tissue in organs, etc.

Priority: US2001-759094 Applic. Date: 2001-01-12; US20000176175P Applic. Date: 2000-01-13

Inventor: MCDANIEL DAVID H [US]


Patent No.: US6663852B2  Issued: 16/Dec/2003

Title: Method and makeup kit containing goniochromatic and monochromatic pigments

Applicant/Assignee: L'OREAL

Application No.: 10/218405   Filing Date: 15/Aug/2002

Abstract:

The present invention relates to a new makeup kit comprising a first, goniochromatic pigment composition which is intended to form a base layer and a second, conventional pigment composition having one of the colors of the first pigment, the second composition being intended to form a surface layer comprising decorative motifs. Depending on the viewing angle, therefore, it is possible to see the said motifs appear or disappear. This kit is intended in particular for making up the nails, lips, cheeks or eyelids, or else the body. The invention also relates to a method of making up the human face, lips or body.

Priority: FR19980004581 Applic. Date: 1998-04-10; US1999-289817 Applic. Date: 1999-04-12

Inventor: SIMON JEAN-CHRISTOPHE [FR]


Patent No.: US6664406B1  Issued: 16/Dec/2003

Title: Nervonic acid derivatives, their preparation and use

Applicant/Assignee: CRODA INTERNATIONAL PLC

Application No.: 10/130672   Filing Date: 19/Aug/2002

Abstract:

The present invention relates to a nervonic acid derivatives of formula (I)wherein R is hydrogen (H) or a residue of a carboxylic acid

or a salt of the compound where R is H

or a bioprecursor, prodrug thereof. Those compounds wherein R is other than H have pharmacological activity, in particular anti-inflammatory and immunomodulatory effects. Those compounds wherein R is H can be used to prepare the pharmacologically active derivatives.

Priority: GB19990027629 Applic. Date: 1999-11-24; WO2000GB04453 Applic. Date: 2000-11-23

Inventor: COUPLAND KEITH [GB]; RAOUL YANN [GB]


Patent No.: US6667052B2  Issued: 23/Dec/2003

Title: Transdermal delivery system

Applicant/Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

Application No.: 09/928131   Filing Date: 10/Aug/2001

Abstract:

The invention provides a transdermal delivery system for treating diabetes and other pathologic systemic conditions, comprising an active ingredient selected from the group consisting of peptides and proteins having an S-S bond and mixtures thereof and a pharmaceutically acceptable oxidizing agent selected from the group consisting of iodine, povidine-iodine and sources thereof, said system being essentially free of reducing agents and said oxidizing agent enabling and facilitating the penetration of said active ingredient through the skin layers and into the blood stream.

Priority: IL19970120943 Applic. Date: 1997-05-29; US1999-424525 Applic. Date: 1999-11-23

Inventor: SINTOV AMNON [IL]; WORMSER URI [IL]


Patent No.: US6669966B1  Issued: 30/Dec/2003

Title: Compositions for facilitating skin growth and methods and articles using same

Applicant/Assignee: MARANTECH HOLDING LLC

Application No.: 09/692127   Filing Date: 20/Oct/2000

Abstract:

Skin-growth-enhancing compounds and compositions including a therapeutically effective amount of at least one electron active compound, or a pharmaceutically acceptable derivative thereof, that has at least two polyvalent cations, at least one of which has a first valence state and at least one of which has a second, different valence state. Preferred compounds include Bi(III,V) oxide, Co(II,III) oxide, Cu(I,III) oxide, Fe(II,III) oxide, Mn(II,III) oxide, and Pr(III,IV) oxide, and Ag(I,III) oxide, or a combination thereof. These compounds may be in a crystalline state having metallic cations of two different valences, or electronic states, in the inorganic crystal. Also included are articles containing such compositions, such as wound dressings, and methods for facilitating or enhancing skin growth using these compounds, compositions, and articles, such as for the treatment or management of burns or skin grafts.

Priority: US2000-552172 Applic. Date: 2000-04-18; US20000174793P Applic. Date: 2000-01-06; US20000184053P Applic. Date: 2000-02-22; US20000214503P Applic. Date: 2000-06-28

Inventor: ANTELMAN MARVIN S [IL]


Patent No.: US6670147B1  Issued: 30/Dec/2003

Title: Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use

Applicant/Assignee: AVENTIS PHARMA DEUTSCHLAND GMBH

Application No.: 09/256237   Filing Date: 24/Feb/1999

Abstract:

The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.

Priority: DE19971001141 Applic. Date: 1997-01-16; US1998-008308 Applic. Date: 1998-01-16

Inventor: HEIDTMANN HANS HEINRICH [DE]; MUELLER ROLF [DE]; SEDLACEK HANS-HARALD [DE]


Patent No.: US6673336B2  Issued: 06/Jan/2004

Title: Conjugate, its preparation and use

Applicant/Assignee: MERCK PATENT, GMBH

Application No.: 10/010449   Filing Date: 07/Nov/2001

Abstract:

The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.

Priority: DE20001055588 Applic. Date: 2000-11-09

Inventor: BUCHHOLZ HERWIG [US]; POETSCH EIKE [US]; ROSSKOPF RALF [US]; ANSELMANN RALF [US]; KIRSCHBAUM MICHAEL [US]; PFLUECKER FRANK [US]


Patent No.: US6673755B2  Issued: 06/Jan/2004

Title: Personal cleansing compositions containing cleansing and skin active phases separated by one or more packaging barriers

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/050494   Filing Date: 16/Jan/2002

Abstract:

Disclosed are personal cleansing compositions, and corresponding methods of application, wherein the compositions comprise (A) a cleansing phase containing a cleansing surfactant and water

and (B) an active phase containing lipophilic carrier and preferably a skin active agent

wherein the cleansing and active phases are physically separated from one another by one or more packaging barriers, located in the same or separate packages. Preferred embodiments are further defined by selected lipophilic carrier rheologies, defined active phase particulates for improved skin feel, and selected chronic skin active agents for use in the active phase. These compositions and corresponding methods provide improved cosmetics, skin feel, and/or skin active efficacy.

Priority:

Inventor: WEI KARL SHIQING [US]; WESNER JOHN CHRISTOPHER [US]; THOMAS CHEYNE POHLMAN [US]; PUTMAN CHRISTOPHER DEAN [US]; ALBACARYS LOURDES DESSUS [US]; SMITH III EDWARD DEWEY [US]


Patent No.: US6673776B1  Issued: 06/Jan/2004

Title: Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human

Applicant/Assignee: VICAL INCORPORATED WISCONSIN ALUMNI RESEARCH FOUNDATION

Application No.: 08/481932   Filing Date: 07/Jun/1995

Abstract:

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.

Priority: US1994-215405 Applic. Date: 1994-03-18; US1992-846827 Applic. Date: 1992-03-06; US1990-496991 Applic. Date: 1990-03-21; US1990-467881 Applic. Date: 1990-01-19; US1989-326305 Applic. Date: 1989-03-21

Inventor: FELGNER PHILIP L [US]; WOLFF JON ASHER [US]; RHODES GARY H [US]; MALONE ROBERT WALLACE [US]; CARSON DENNIS A [US]


Patent No.: US6673798B2  Issued: 06/Jan/2004

Title: PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same

Applicant/Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

Application No.: 09/828602   Filing Date: 09/Apr/2001

Abstract:

A purified tyrphostin of a general formula:wherein, for Compound I, R6 is either at position 6 or at position 7, or, for Compound II, R6 is either at position 6 or at position 8.

Priority: US1999-436651 Applic. Date: 1999-11-09

Inventor: LEVITZKI ALEXANDER [IL]; GAZIT AVIV [IL]; BANAI SHMUEL [IL]; GERTZ DAVID S [IL]; GOLOMB GERSHON [IL]; BOEHMER FRANK D [DE]; WALTENBERGER JOHANNES [DE]


Patent No.: US6673863B2  Issued: 06/Jan/2004

Title: Gel composition and methods of use

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 10/023029   Filing Date: 17/Dec/2001

Abstract:

There is provided a gel composition having a silica powder and a non-volatile compound. The silica powder particles are spherical and porous. The silica powder has a specific gravity about 0.09 to about 0.6, and is present in an amount about 10 wt % to about 50 wt %. The non-volatile compound is present from about 35 wt % to about 90 wt %. The composition has less than about 5 wt % water. There is also provided a method for imparting a powdery feel to the skin, and a method for treating a cosmetic or medical condition of the skin, nail/cuticle, lips or hair.

Priority:

Inventor: TRAVKINA IRINA [US]; LAMBERTY LISA [US]; PAHLCK HAROLD [US]


Patent No.: US6680048B2  Issued: 20/Jan/2004

Title: Esters

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO INC UNILEVER HOME & PERSONAL CARE USA, A DIVISION OF CONOPCO, INC

Application No.: 09/978954   Filing Date: 17/Oct/2001

Abstract:

Cellobiose esters and particularly alpha cellobiose octanonanoate has been found able to structure water-immiscible liquids well, and in particular can produce clear structured emulsions. However, such emulsions tend to lose clarity or structural strength during storage. Deviating from alpha-cellobiose octanonanoate can result in impaired clarity and/or impaired hardness of emulsion sticks. However, acylated cellobiose which contains acyl substituents of formula -O-CO-R in which R represents an n-octyl residue and the percentage Y of the nonanoate acyl substituent -O-CO-R at the anomeric carbon is at least 60% and the percentage A of alpha anomer is greater than the anomer and not higher than A=74.5 +0.2Y when Y is up to 92% and not higher than A=161-0.74Y when Y is greater than 92% offers the production of sticks combining structurant stability with product clarity and hardness.

Priority: GB20000025438 Applic. Date: 2000-10-17

Inventor: GRAINGER LYNDA [GB]; GRANSDEN KATHRYN ELIZABETH [GB]; HOPKINSON ANDREW [GB]; KOWALSKI ADAM JAN [GB]; WEBB NICHOLAS [GB]; WHITE MICHAEL STEPHEN [GB]


Patent No.: US6680345B2  Issued: 20/Jan/2004

Title: Salicylic acid salts of salmeterol

Applicant/Assignee: BOEHRINGER INGELHEIM PHARMA KG

Application No.: 10/242249   Filing Date: 12/Sep/2002

Abstract:

The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their use

Priority: DE20011045438 Applic. Date: 2001-09-14; US20020386172P Applic. Date: 2002-06-05; DE20021016125 Applic. Date: 2002-04-12

Inventor: LINZ GUENTER [DE]; SOYKA RAINER [DE]; STEINER ANDRE [DE]


Patent No.: US6682244B2  Issued: 27/Jan/2004

Title: Devices and methods for dispensing

Applicant/Assignee: L'OREAL S.A

Application No.: 09/859444   Filing Date: 18/May/2001

Abstract:

A device for dispensing comprises a reservoir containing a composition comprising particles containing at least one fluid, an application member having at least a portion removably disposed within the reservoir and configured to be loaded with the composition and a compacting member configured to exert pressure on at least the portion of the application member during removal of the portion of the application member from the reservoir.

Priority: FR20000006449 Applic. Date: 2000-05-19

Inventor: GUERET JEAN-LOUIS H [FR]


Patent No.: US6682726B2  Issued: 27/Jan/2004

Title: Self-foaming shaving lotion

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 09/845853   Filing Date: 30/Apr/2001

Abstract:

The present invention is directed to a self-foaming shaving composition in the form of a lotion. The shaving composition comprises water, a water dispersible surface active agent capable of forming a lather, a volatile self-foaming agent, and a water soluble thickening agent wherein the composition is in the form of a self-foaming lotion having an elastic modulus (G') of about 100 to about 1000 Pascals, preferably about 200 to about 900 Pa, most preferably about 400 to about 800 Pa (measured with a rheometer at frequency 1 Hz, oscillatory stress range 0.01-1.0 Pa, temperature 5 DEG C., Gap 1000 mum). The present invention is also directed to an improved shaving method in which a shaving composition of the present invention is applied to an area of skin, then said area is shaved, preferably with a wet razor.

Priority:

Inventor: MARCHESI JENIFER T [US]; XU YUN [US]; DODD KENNETH T [US]


Patent No.: US6682748B1  Issued: 27/Jan/2004

Title: Transfer-free cosmetic composition comprising a dispersion of polymer particles in a liquid fatty phase and a fat-soluble polymer

Applicant/Assignee: L'OREAL

Application No.: 09/218459   Filing Date: 22/Dec/1998

Abstract:

A composition suitable for topical application, which contains:a liquid fatty phase,at least one coloring agent,at least 2% by weight, with respect to the total weight of the composition, of a polymer which is dispersible in the liquid fatty phase, anda polymer which is soluble in the liquid fatty phase.In preferred embodiments, the composition may be provided in the form of a cast product or of a gel containing at least one coloring material, in particular pulverulent coloring material, a dispersion of polymer particles which are stabilized at the surface in a liquid fatty phase and a fat-soluble polymer of the vinylpyrrolidone copolymer type. In addition, according to the amount of polymer, it is possible to obtain, on the lips or skin, a supple film having notable transfer-free properties while being extremely comfortable. The invention also relates to the use of this dispersion in such a composition.

Priority: FR19970016254 Applic. Date: 1997-12-22

Inventor: DE LA POTERIE VALERIE [FR]; MOUGIN NATHALIE [FR]


Patent No.: US6682750B2  Issued: 27/Jan/2004

Title: Surfactant-free cosmetic, dermatological and pharmaceutical compositions

Applicant/Assignee: CLARIANT GMBH

Application No.: 10/086039   Filing Date: 28/Feb/2002

Abstract:

The invention relates to surfactant-free cosmetic, dermatological and pharmaceutical compositions, comprising at least one copolymer consisting essentially ofa1) 1 to 50% by weight of the repeat structural unit of the formula (1)where n is an integer from 2 to 9, ora2) 1 to 50% by weight of a mixture of the repeat structural unit of the formula (1) and the repeat structural unit of the formula (2)where R, R<1 >and R<2 >may be identical or different and are hydrogen or a linear or branched alkyl or alkenyl group having in each case 1 to 30 carbon atoms andb) 49.99 to 98.99% by weight of the repeat structural unit of the formula (3)in which R<3 >is hydrogen, methyl or ethyl, Z is (C1-C8)-alkylene, n is an integer from 2 to 9 and X is an ammonium, alkali metal or alkaline earth metal ion andc)

0.01 to 8% by weight of crosslinking structures which originate from monomers having at least two olefinic double bonds.

Priority: DE20011010336 Applic. Date: 2001-03-03

Inventor: LOEFFLER MATTHIAS [DE]; MORSCHHAEUSER ROMAN [DE]; HORNUNG MICHAEL [DE]


Patent No.: US6685924B2  Issued: 03/Feb/2004

Title: Conjugate, its preparation and use

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 10/010142   Filing Date: 07/Nov/2001

Abstract:

The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.

Priority: DE20001055469 Applic. Date: 2000-11-09

Inventor: BUCHHOLZ HERWIG [DE]; ANSELMANN RALF [DE]; DRILLER HANSJUERGEN [DE]; KIRSCHBAUM MICHAEL [DE]; PFLUECKER FRANK [DE]


Patent No.: US6686457B1  Issued: 03/Feb/2004

Title: Material

Applicant/Assignee:

Application No.: 09/722241   Filing Date: 27/Nov/2000

Abstract:

Material characterized by that the material contains at least one biologically active saccharide which is covalently bound via at least one spacer to a crosslinked matrix.

Priority: US1996-091486 Applic. Date: 1996-12-23; SE20000002462 Applic. Date: 2000-06-28; SE20000000430 Applic. Date: 2000-02-08; SE20000004343 Applic. Date: 2000-11-24

Inventor: NILSSON KURT [SE]


Patent No.: US6689345B2  Issued: 10/Feb/2004

Title: Care or make-up composition containing fibers and a hydrophilic polyorganosiloxane

Applicant/Assignee: L'OREAL

Application No.: 10/251856   Filing Date: 23/Sep/2002

Abstract:

A care or make-up composition for keratin substances such as the skin, the lips or superficial body growths, this composition containing fibers and particles of an at least partially crosslinked solid elastomeric polyorganosiloxane suspended in an aqueous phase, giving a homogeneous deposit on these keratin substances, while at the same time providing softness and a sensation of freshness

methods of using the composition

and methods of making the composition.

Priority: FR19990008489 Applic. Date: 1999-07-01; US2000-607627 Applic. Date: 2000-06-30

Inventor: JAGER LEZER NATHALIE [FR]


Patent No.: US6689349B1  Issued: 10/Feb/2004

Title: Skin protection agents containing a fragment mixture produced from hyaluronic acid by hydrolysis

Applicant/Assignee: ESPARMA GMBH

Application No.: 09/868955   Filing Date: 10/Sep/2001

Abstract:

The invention relates to an agent for the treatment, prophylaxis and metaphylaxis of functional and structural disorders of the skin caused by external factors. The agent contains a hyaluronic acid partially digested with a microbiological hyaluronate lyase. The hyaluronic acid fragment mixture is incorporated in different galenic formulations to which other hydrophilic and/or lipophilic active substances and/or auxiliary substances can be added. Fields of application of the invention in human and veterinary medicine relate to the treatment and/or the prophylaxis of skin damage caused by environmental factors including UV, dry skin conditions and skin ageing.

Priority: DE19981060544 Applic. Date: 1998-12-23; WO1999EP10336 Applic. Date: 1999-12-22

Inventor: WOHLRAB WOLFGANG [DE]; NEUBERT REINHARD [DE]; HUSCHKA CHRISTOPH [DE]; MUELLER PETER-JUERGEN [DE]; OZEGOWSKI JOERG-HERMAN [DE]; KOEGST DIETER [DE]; FRIES GERHARD [DE]


Patent No.: US6689371B1  Issued: 10/Feb/2004

Title: Nanoemulsion based on sugar fatty esters or on sugar fatty ethers and its uses in the cosmetics, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 09/460092   Filing Date: 13/Dec/1999

Abstract:

A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45 DEG C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Priority: FR19980015765 Applic. Date: 1998-12-14

Inventor: SIMONNET JEAN-THIERRY [FR]; SONNEVILLE ODILE [FR]; LEGRET SYLVIE [FR]


Patent No.: US6689379B1  Issued: 10/Feb/2004

Title: Transdermal therapeutic system with neutralized acrylic adhesive patch

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/959288   Filing Date: 19/Oct/2001

Abstract:

A transdermal therapeutic system embodied as a matrix or reservoir system is characterized bya content of at least one basic- or neutral-reacting pharmaceutical active agenta content of a pressure-sensitive adhesive polymer which possesses as part of its chain acrylic acid or methacrylic acid units, the content of the carboxyl groups, relative to the mean polymer mass, being 0.5 to 10.0% (w/w) and the carboxyl groups being present stoichiometrically at 5 to 100 %, preferably 10 to 50%, in form of alkali salts or alkaline earth salts.Water-binding additives may also be present, for reducing the sensitivity to moisture.

Priority: DE19991018106 Applic. Date: 1999-04-22; WO2000EP03112 Applic. Date: 2000-04-07

Inventor: BRACHT STEFAN [DE]


Patent No.: US6692770B2  Issued: 17/Feb/2004

Title: Starch microparticles

Applicant/Assignee: JAGOTEC AG

Application No.: 10/461445   Filing Date: 16/Jun/2003

Abstract:

A process for producing parenterally administrable microparticles, in which an at least 20% by weight aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are med to gel, and the gelled starch particles are dried. A release-controlling shell is optionally also applied to the particles. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 mug and have no covalent chemical cross-linking.

Priority: SE20000003615 Applic. Date: 2000-10-06; US2001-970793 Applic. Date: 2001-10-05; US20010260455P Applic. Date: 2001-01-08

Inventor: GUSTAVSSON NILS OVE [SE]; JOENSSON MONICA [SE]; LAAKSO TIMO [GB]; RESLOW MATS [SE]


Patent No.: US6693135B2  Issued: 17/Feb/2004

Title: Prostaglandin compositions and methods of treatment for male erectile dysfunction

Applicant/Assignee: NEXMED (HOLDINGS), INC NEXMED (HOLDINGS) INCORPORATED

Application No.: 09/947617   Filing Date: 06/Sep/2001

Abstract:

The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency, as well as suitable applicators. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

Priority: WO2001US00852 Applic. Date: 2001-01-10; US2000-480738 Applic. Date: 2000-01-10

Inventor: YEAGER JAMES L [US]; BUYUKTIMKIN NADIR [US]; BUYUKTIMKIN SERVET [US]


Patent No.: US6696049B2  Issued: 24/Feb/2004

Title: Cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/851507   Filing Date: 08/May/2001

Abstract:

The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.

Priority: US20000217211P Applic. Date: 2000-07-10; US20010276998P Applic. Date: 2001-03-19

Inventor: VATTER MICHAEL LEE [US]; SUNKEL JORGE MAX [US]


Patent No.: US6696067B2  Issued: 24/Feb/2004

Title: Cosmetic compositions containing dispersion polymers

Applicant/Assignee: ONDEO NALCO COMPANY

Application No.: 09/834128   Filing Date: 12/Apr/2001

Abstract:

A cosmetically acceptable composition for treating hair, skin and nails comprising from about 0.001 to about 25 weight percent, based on polymer solids, of a stable dispersion in an aqueous salt solution of a cationic, anionic or nonionic polymer having a weight average molecular weight of from about 10,000 to about 50,000,000 and a method of treating hair, skin or nails are disclosed.

Priority:

Inventor: BRANDT LORALEI MARIE [US]; BETTS DOUGLAS E [US]; JOHNSON CATHY C [US]


Patent No.: US6696417B1  Issued: 24/Feb/2004

Title: Skin and hair darkening composition

Applicant/Assignee: CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC

Application No.: 09/191974   Filing Date: 13/Nov/1998

Abstract:

A cosmetic skin/hair darkening composition for topical application to skin and/or hair is provided that comprises for 0.1 to 10% by weight of a peptide having an isoelectric point ranging from 6 to 11.

Priority: GB19980001191 Applic. Date: 1998-01-20; IN1997BO00684 Applic. Date: 1997-11-21

Inventor: RAGHUPATHI SUBRAMANIAN [IN]; RAMAIAH ABBURI [IN]; RAMAN GOVINDARAJAN [IN]; WAGH SUSHAMA SHRIPAD [IN]


Patent No.: US6696575B2  Issued: 24/Feb/2004

Title: Biodegradable, electrically conducting polymer for tissue engineering applications

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 10/107705   Filing Date: 27/Mar/2002

Abstract:

The subject matter of the present invention includes a novel biodegradable conducting polymer for biomedical applications. The polymer combines mixed heteroaromatic conductive segments of pyrrole and thiophene with flexible aliphatic chains via degradable ester linkages. In addition to its utility for peripheral nerve regeneration, the polymer may be applied to other areas of tissue engineering, including spinal cord regeneration, wound healing, bone repair, muscle tissue stimulation, and other regenerative, restorative, reconstructive, therapeutic, prophylactic, and diagnostic functions.

Priority: US20010279019P Applic. Date: 2001-03-27

Inventor: SCHMIDT CHRISTINE E [US]; RIVERS TYRELL J [US]


Patent No.: US6699460B2  Issued: 02/Mar/2004

Title: UV-photostabilized sunscreen compositions comprising dibenzoylmethane/triazine/benzophenone compounds

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/314184   Filing Date: 09/Dec/2002

Abstract:

Topically applicable cosmetic/dermatological sunscreen compositions well suited for the stable UV-photoprotection of human skin and/or hair, are devoid of any p-methylbenzylidenecamphor, but which contain (a) an effective photoprotecting amount of at least one UV-sunscreening dibenzoylmethane compound, (b) an effective photoprotecting amount of at least one UV-screening 1,3,5-triazine compound normally photosensitive in the presence of a dibenzoylmethane compound (a), and (c) an effective photostabilizing amount of at least one UV-screening amino-substituted 2-hydrozybenzophenone compound having the following structural formula (VIII):formulated into (d) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010015859 Applic. Date: 2001-12-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6699461B2  Issued: 02/Mar/2004

Title: UV-photostabilized sunscreen compositions comprising dibenzoylmethane/benzophenone compounds

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/314186   Filing Date: 09/Dec/2002

Abstract:

Topically applicable cosmetic/dermatological sunscreen compositions well suited for the stable UV-photoprotection of human skin and/or hair are devoid of any p-methylbenzylidenecamphor, but contain (a) an effective photoprotecting amount of at least one UV-screening dibenzoylmethane compound, and (b) an effective photostabilizing amount of at least on UV-screening amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I):formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010015858 Applic. Date: 2001-12-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6699824B1  Issued: 02/Mar/2004

Title: Cleansing compositions comprising highly branched polyalphaolefins

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/889950   Filing Date: 24/Jul/2001

Abstract:

A rinse-off liquid personal cleansing composition comprising: (a) water

(b) from about 1% to about 60% by weight of a water soluble surfactant

(c) a water-insoluble oil selected from highly branched polyalphaolefins having formula (A) wherein R<1 >is H or C1-C20 alkyl, R<4 >is C1-C20 alkyl, R<2 >is H or C1-C20, and R<3 >is C3-C20 preferably from C5-C20, n is an integer from 0 to 3 and m is an interger of from 1 to 1000 and having a number average molecular weight of from about 1000 to about 25,000

and (d) a hydrophobic skin active component selected from antimicrobial agents, sunscreens, vitamins, perfume oils, insect repellents, anti fungal agents, and mixtures thereof, wherein the hydrophobic skin active component has a ClogP value of greater than 3. The personal cleansing compositions of the invention provide improved deposition of hydrophobic skin actives, excellent rinse feel and skin mildness.

Priority: WO2000US01390 Applic. Date: 2000-01-20

Inventor: DAWSON GEORGE GEOFFREY [GB]; VANOOSTHUYZE KRISTINA [GB]


Patent No.: US6703002B2  Issued: 09/Mar/2004

Title: Synergistically UV-photoprotecting sunscreen compositions comprising camphorsulfonic acid/benzophenone compounds

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 10/314188   Filing Date: 09/Dec/2002

Abstract:

Topically applicable cosmetic/dermatological sunscreen compositions well suited for the enhanced UV-photoprotection of human skin and/or hair, contain synergistically SPF-enhancing amounts of (a) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid), optionally in partially or completely neutralized state, and (b) at least one amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I):formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR20010015861 Applic. Date: 2001-12-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6703026B2  Issued: 09/Mar/2004

Title: COSMETIC COMPOSITION CONTAINING A POLYORGANOSILOXANE AND AN ACRYLIC TERPOLYMER, AND USE OF THIS COMPOSITION FOR TREATING KERATINOUS MATERIAL

Applicant/Assignee: L'OREAL

Application No.: 09/332003   Filing Date: 14/Jun/1999

Abstract:

The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one polyorganosiloxane and an acrylic terpolymer, as well as to the use of these compositions for treating keratinous material, in particular the skin or the hair. The acrylic terpolymer comprises:a) about 20 to 70% by weight of a carboxylic acid containing alpha,beta-monoethylenic unsaturation

b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), andc) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation. The polyorganosiloxane is preferably a non-volatile silicone.

Priority: FR19980007512 Applic. Date: 1998-06-15

Inventor: DUPUIS CHRISTINE [FR]


Patent No.: US6703427B2  Issued: 09/Mar/2004

Title: Method of preparing particularly skin-compatible cosmetic or dermatological cleansing preparations

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/738789   Filing Date: 15/Dec/2000

Abstract:

The use of one or more cosurfactant (surfactant B) in a mixture with one or more surfactants different from surfactant B (surfactant A) for reducing the binding of surfactant A to the surface of the skin.

Priority: DE19991060767 Applic. Date: 1999-12-16

Inventor: SCHMUCKER ROBERT [DE]; SUGAR MARTIN [DE]


Patent No.: US6706058B2  Issued: 16/Mar/2004

Title: Resorbable, synthetic, medical coating material, method for its manufacture and its use in medicine

Applicant/Assignee: DEUTSCHE INSTITUTE FUR TEXTIL- UND FASERFORSCHUNG STUTTGART STIFTUNG DES OFFENTLICHEN RECHTS

Application No.: 09/930177   Filing Date: 16/Aug/2001

Abstract:

The invention relates to a coating material for medical treatment, particularly a wound contact material, of resorbable, synthetic material, which is formed from a terpolymer based on lactide, trimethylene carbonate and epsilon-caprolactone with a maximum lactide content of 85 wt. %, trimethylene carbonate in the range 5 to 20 wt. % and epsilon-caprolactone in the range 5 to 20 wt. %, a method for its manufacture and its use.

Priority: DE20001041684 Applic. Date: 2000-08-24

Inventor: HIERLEMANN HELMUT [DE]; PLANCK HEINRICH [DE]


Patent No.: US6706506B2  Issued: 16/Mar/2004

Title: Detection of epithelial cell cancers and precancerous conditions

Applicant/Assignee: CORNELL RESEARCH FOUNDATION, INC

Application No.: 09/911343   Filing Date: 23/Jul/2001

Abstract:

Epithelial cell cancers and precancerous conditions are detected by assaying for LRAT expression. Failure to detect LRAT expression indicates presence of cancer, and detection of lower than normal level of LRAT expression indicates a precancerous condition.

Priority: US20000220222P Applic. Date: 2000-07-24

Inventor: GUDAS LORRAINE J [US]; GUO XIAOJIO [US]


Patent No.: US6709663B2  Issued: 23/Mar/2004

Title: Multivesicular emulsion drug delivery systems

Applicant/Assignee: HEALTHPOINT, LTD

Application No.: 09/944760   Filing Date: 31/Aug/2001

Abstract:

A topical delivery composition which employs a multivesicular emulsion in combination with a pharmaceutically/pharmacologically active agent is disclosed. The multivesicular emulsion is formed from a quaternary amine salt emulsifier such as behentrimonium methosulfate. The emulsion is multi-lamellar which is a series of concentric spheres or vesiculars of oil and water phase that can be seen microscopically. As a result, the active is time released over a sustained period rather than spike released as is common with most topicals.

Priority:

Inventor: ESPINOZA ROBERT [US]


Patent No.: US6713051B2  Issued: 30/Mar/2004

Title: Antiperspirant or deodorant compositions

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 10/174245   Filing Date: 18/Jun/2002

Abstract:

Antiperspirant compositions comprising an astringent aluminum or zirconium salt can suffer from perceived irritancy when applied topically, which can be ameliorated or overcome by incorporating within the composition a PPAR activating fatty acid and/or hydrolyzable precursor thereof such as a triglyceride or ester of the PPAR, especially in an amount selected in the range of from 0.5 to 10 wt %.The compositions advantageously comprise an activated aluminum salt or aluminum-zirconium glycine complex.

Priority: GB20010014848 Applic. Date: 2001-06-18

Inventor: MAYES ANDREW EASSON [GB]; RAWLINGS ANTHONY VINCENT [GB]; WATKINSON ALLAN [GB]


Patent No.: US6713075B2  Issued: 30/Mar/2004

Title: Topical composition comprising an aldehyde or ketone-based cosmetic bonding agent

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/092124   Filing Date: 06/Mar/2002

Abstract:

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a bonding agent selected from the group consisting of aldehydes and ketones having the structurewherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and R represents hydrogen, straight or branched alkyls, substituted or unsubstituted aryls, and combinations thereof

and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

Priority: US20010273997P Applic. Date: 2001-03-07

Inventor: BEKELE HAIMANOT [US]


Patent No.: US6716418B2  Issued: 06/Apr/2004

Title: Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same

Applicant/Assignee: AMCOL INTERNATIONAL CORP

Application No.: 10/277470   Filing Date: 22/Oct/2002

Abstract:

Cosmetic and personal care compositions can be manufactured using the multifunctional-additive compositions of the present invention. Such an additive preferably contains one or more particulate-based thickeners, such as a smectite clay, colloidal silica, laponite, and/or alumina, and most preferably one or more smectite clays. According to one important embodiment of the present invention, the thickener particles are co-dispersed with particles of one or more particulate UVR-filters such as titanium dioxide, zinc oxide, or SUNSPHERE (available from International Specialty Chemicals, ISP), and most preferably with the natural particulate sunscreens such as the metal oxides.

Another important component of the multifunctional-additive compositions is a dispersant or surface-modifier for the foregoing particulate materials, selected from the family of polyphenolic, natural polymers such as lignosulfonates, lignins, humates, tannates, and derivatives thereof. In addition, these compositions optionally include one or more of the following components: electrolytes, defoamers, humectants, emollients for cosmetics, preservatives, whiteners, and the like.

Priority: US2002-068268 Applic. Date: 2002-02-05; US20010266596P Applic. Date: 2001-02-05; US20010318979P Applic. Date: 2001-09-13

Inventor: SENGUPTA ASHOKE K [US]; SPINDLER RALPH [US]; DARLINGTON JR JERALD W [US]


Patent No.: US6716437B1  Issued: 06/Apr/2004

Title: Topical composition and method for enhancing lipid barrier synthesis

Applicant/Assignee: E-L MANAGEMENT CORPORATION

Application No.: 09/806667   Filing Date: 02/Apr/2001

Abstract:

The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.

Priority: US1993-712988 Applic. Date: 1993-09-13; WO1997US16364 Applic. Date: 1997-09-11

Inventor: PELLE EDWARD [US]; ANDERSON JON [US]


Patent No.: US6716441B1  Issued: 06/Apr/2004

Title: Compositions for efficient release of active ingredients

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/466343   Filing Date: 17/Dec/1999

Abstract:

The present invention relates to a novel composition for efficiently releasing hydrophilic or water-soluble skin care actives from an oleaginous composition. The substantially oleaginous composition of the present invention comprises: (1) at least one skin care active

(2) a release agent having an HLB of at least about 3

and (3) a hydrophobic barrier protectant. The novel release composition may be topically applied to skin using a dispensing means such as an absorbent article, a wipe, a bandage, a pad, a canister, a stick, an aerosol dispenser, a sprayer, and the like.

Priority: US1998-041266 Applic. Date: 1998-03-12

Inventor: OSBORNE SCOTT EDWARD [US]; DECKNER GEORGE ENDEL [US]; KLOFTA THOMAS JAMES [US]; VEGA VICTOR NICHOLAS [US]


Patent No.: US6719540B2  Issued: 13/Apr/2004

Title: C3-CYANO EPOTHILONE DERIVATIVES

Applicant/Assignee: BRISTOL-MYERS SQUIBB COMPANY

Application No.: 10/386072   Filing Date: 11/Mar/2003

Abstract:

The present invention relates to compounds useful in the treatment of cancer or other proliferative diseases represented by formula I:wherein:Q is selected from the group consisting ofM is O, NR9, or CR10R11

X is O or NH

and the R groups are as defined, and therapeutic compositions containing them alone or in combination with other therapeutic agents useful in the treatment of cancer or other proliferative diseases.

Priority: US20020363441P Applic. Date: 2002-03-12

Inventor: REGUEIRO-REN ALICIA [US]; KIM SOONG-HOON [US]


Patent No.: US6719959B1  Issued: 13/Apr/2004

Title: Extended duration insect repellent composition and method of application to the skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 09/724160   Filing Date: 28/Nov/2000

Abstract:

Disclosed is an insect repellent composition. The composition has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin, and an amount of a urethane polymer sufficient to form a film on the surface of the skin. The composition also has a cosmetically-acceptable vehicle. Also disclosed is a method of repelling insects from the skin by applying the composition to the skin.

Priority:

Inventor: GONZALEZ ANTHONY [US]; PECHKO ANDREW H [US]; KALAFSKY ROBERT E [US]


Patent No.: US6719986B1  Issued: 13/Apr/2004

Title: Hyaluronate lyase used for promoting penetration in topical agents

Applicant/Assignee: ESPARMA GMBH

Application No.: 09/869087   Filing Date: 05/Sep/2001

Abstract:

The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on the basis of different medicaments and/or auxiliary substances through promotion of penetration from topical formulations into the skin. According to the invention, the agent is composed of a hyaluronate lyase produced by microbial means and a medicament, preferably a hydrophilic medicament and/or auxiliary substances in different galenic formulations including colloidal carrier systems. The areas of application for the invention in human and veterinary medicament relate to the treatment, prophylaxis and/or metaphylaxis of skin diseases, functional disorders of the skin, the processes of skin ageing and dry skin conditions.

Priority: DE19981060545 Applic. Date: 1998-12-23; WO1999EP10337 Applic. Date: 1999-12-22

Inventor: WOHLRAB WOLFGANG [DE]; NEUBERT REINHARD [DE]; HUSCHKA CHRISTOPH [DE]; MUELLER PETER-JUERGEN [DE]; OZEGOWSKI JOERG-HERMAN [DE]; KOEGST DIETER [DE]; FRIES GERHARD [DE]


Patent No.: US6719997B2  Issued: 13/Apr/2004

Title: Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers

Applicant/Assignee: DERMATRENDS, INC

Application No.: 09/738395   Filing Date: 14/Dec/2000

Abstract:

Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing agents are inorganic hydroxides, inorganic oxides, and alkali metal or alkaline earth metal salts of weak acids. Inorganic hydroxides include, for example, ammonium hydroxide, alkali metal hydroxides and alkaline earth metal hydroxides, such as sodium hydroxide, calcium hydroxide, potassium hydroxide, magnesium hydroxide, and the like.

Priority: US2000-607892 Applic. Date: 2000-06-30

Inventor: HSU TSUNG-MIN [US]; MACY RUSSELL [US]; LUO ERIC C [US]


Patent No.: US6720009B2  Issued: 13/Apr/2004

Title: Matrix protein compositions for treating infection

Applicant/Assignee: BIORA BIOEX AB

Application No.: 10/156300   Filing Date: 28/May/2002

Abstract:

Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.

Priority: DK19980000270 Applic. Date: 1998-02-27; DK19980001328 Applic. Date: 1998-10-16; US1999-258613 Applic. Date: 1999-02-26; US19980081551P Applic. Date: 1998-04-13

Inventor: GESTRELIUS STINA [SE]; HAMMARSTROEM LARS [SE]; LYNGSTADAAS PETTER [NO]; ANDERSSON CHRISTER [SE]; SLABY IVAN [SE]; HAMMARGREN TOMAS [SE]


Patent No.: US6723077B2  Issued: 20/Apr/2004

Title: Cutaneous administration system

Applicant/Assignee: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P

Application No.: 09/967603   Filing Date: 28/Sep/2001

Abstract:

Bioactive agents are cutaneously delivered by a jet dispenser using inkjet technology, such as that used in printing. The dispenser propels precise volumes of bioactive agent toward the skin, where they exert a local or topical effect, or move through the skin for transdermal systemic delivery. Drugs are either delivered directly to the skin, or are introduced into a transdermal patch, which may receive repeated dosages. A controller in the dispenser may control delivery of multiple different drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient, such as those monitored by a sensor in communication with the controller, for example to prevent an overdose. The dispenser may act as an electromechanical patch, capable of long term administration of drugs to the skin, to achieve local or systemic pharmaceutical effects.

Administration methods are also provided, along with replacement kits.

Priority:

Inventor: PICKUP RAY L [US]; LO CLEMENT C [US]; NOONAN WILLIAM D [US]


Patent No.: US6723306B2  Issued: 20/Apr/2004

Title: Article for applying artificial tanning agent and method of making

Applicant/Assignee: L'OREAL

Application No.: 10/161877   Filing Date: 05/Jun/2002

Abstract:

An article for applying a skin care product, particularly an artificial tanning agent to the skin. The article includes an adhesive matrix disposed between at least two layers that are permanently bonded to the matrix, with at least one of the layers being permeable to a liquid. The matrix contains at least one artificial tanning agent suitable for acting on the skin when the matrix is put into contact with the liquid so that the artificial tanning agent can be applied to the skin after contacting the article with the liquid. A method of making the article is also provided.

Priority: FR20010007309 Applic. Date: 2001-06-05

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6726915B2  Issued: 27/Apr/2004

Title: Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides

Applicant/Assignee: L'OREAL

Application No.: 10/088296   Filing Date: 10/Apr/2002

Abstract:

The present application relates to a composition, in particular a cosmetic or pharmaceutical composition, which is in solid form, comprising an oily phase and at least one compound of formula (I) below:in which R and R' represent a hydrogen atom or a hydrocarbon-based chain

and A represents a hydrocarbon-based chain.

Priority: FR20000009317 Applic. Date: 2000-07-17; WO2001FR02306 Applic. Date: 2001-07-16

Inventor: LIVOREIL AUDE [FR]; GENARD SYLVIE [FR]


Patent No.: US6730288B1  Issued: 04/May/2004

Title: Mousse composition

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 09/719662   Filing Date: 30/Jan/2001

Abstract:

A pharmaceutical aerosol foam composition including an effective amount of a pharmaceutically active ingredient

an occlusive agent

an aqueous solvent

and an organic cosolvent, the pharmaceutically active ingredient being insoluble in both water and the occlusive agent

the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use.

Priority: AU1998PP05831 Applic. Date: 1998-09-11; WO1999AU00735 Applic. Date: 1999-09-08

Inventor: ABRAM ALBERT ZORKO [AU]


Patent No.: US6730317B2  Issued: 04/May/2004

Title: PATCH, A KIT CONSTITUTED BY A PATCH AND A RECEPTACLE AND A METHOD

Applicant/Assignee: L'OREAL

Application No.: 09/418825   Filing Date: 15/Oct/1999

Abstract:

A patch comprising a matrix having adhesive properties in the dry state and containing at least one active substance, said matrix being attached via one face to a backing and being for application via its other face to the skin. Said backing is selected in such a manner as to be capable of containing a predetermined liquid suitable for dissolving at least in part the active substance(s) contained in the matrix, and said matrix is permeable to the liquid.

Priority: FR19980013129 Applic. Date: 1998-10-20

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6730493B1  Issued: 04/May/2004

Title: Method for determining the state of substances containing keratin and suitable devices and means therefor

Applicant/Assignee: WELLA AKTIENGESELLSCHAFT

Application No.: 09/509897   Filing Date: 30/May/2000

Abstract:

The method for recognizing damage and determining the extent of the damage to a keratin-containing material, such as hair or wool, includes subjecting a sample of it in aqueous solution to an enzymatic and/or chemical treatment for proteolytic or hydrolytic degradation of the sample, and subsequently measuring the turbidity of the resulting liquid sample to determine the extent of the damage, either by visual observation with the naked eye or by physical measurement methods. An apparatus suitable for performing the method and enzymes, such as proteases and proteinases, and chemical agents for carrying out the method are also described.

Priority: DE19981035055 Applic. Date: 1998-08-04; WO1999EP05568 Applic. Date: 1999-08-03

Inventor: SCHWAN-JONCZYK ANNETTE [DE]; HAALCK LUTZ [DE]; UENSAL CEYLAN [DE]; FELDBRUEGGE RAINER [DE]


Patent No.: US6733765B2  Issued: 11/May/2004

Title: Foaming cosmetic cream

Applicant/Assignee: L' OREAL L'OREAL

Application No.: 09/886216   Filing Date: 22/Jun/2001

Abstract:

A composition including a surfactant in an aqueous medium, wherein said surfactant exhibits at least one paracrystalline phase of either a direct type or a cubic type at temperatures varying from 30 DEG C. to 45 DEG C. inclusive.

Priority: FR20000008085 Applic. Date: 2000-06-23

Inventor: GUILLOU VERONIQUE [FR]; MORANCAIS JEAN-LUC [FR]


Patent No.: US6737048B2  Issued: 18/May/2004

Title: Antiperspirant formulations

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/096808   Filing Date: 13/Mar/2002

Abstract:

Structured antiperspirant emulsion formulations for topical application to human skin in a cosmetic method for controlling sweat and body odor generation can suffer from problems of impaired sensory properties and impaired efficacy (sweat reduction), which are ameliorated or overcome in structured antiperspirant emulsions in which (%s by weight of the emulsion)i) the hydrophilic phase comprises 25 to 55%

ii) the hydrophilic phase contains 0 to 15% polyhydric alcohol

iii) the emulsifier comprises an alkyl dimethicone copolyol

iv) the weight ratio of the hydrophilic phase to the emulsifier is selected in the range of at least 60:1v) the structurant comprises an acylated sugar andvi) the water-immiscible oil and the structurant are present in a weight ratio of 1.5:1 to 8.5:1.

Priority: GB20010006601 Applic. Date: 2001-03-16

Inventor: ABEND SVEN JORG WILLI MAX [GB]; COURTOIS JEAN-PHILIPPE ANDRE R [GB]; CROPPER MARTIN PETER [GB]; FLETCHER NEIL ROBERT [GB]; GRAINGER LYNDA [GB]; MURPHY ANGELA MARY [GB]


Patent No.: US6737055B2  Issued: 18/May/2004

Title: Isolated cathepsin L type cysteine proteases and reducing intercorneocyte cohesion/promoting desquamation therewith

Applicant/Assignee: SOCIETE L'OREAL S.A

Application No.: 09/884953   Filing Date: 21/Jun/2001

Abstract:

Isolated, substantially pure natural or synthetic polypeptides comprising cathepsin L type cysteine proteases, or polypeptide fragments or polypeptide admixtures obtained via proteolysis thereof, are useful for reducing intercorneocyte cohesion and, thus, for promoting desquamation.

Priority: FR19970010818 Applic. Date: 1997-08-29; US1998-143446 Applic. Date: 1998-08-28

Inventor: BERNARD DOMINIQUE [FR]; KERMICI MICHEL [FR]; BERNARD-BOURBOULON MARIE-ALIX [FR]


Patent No.: US6737079B2  Issued: 18/May/2004

Title: Bandage composition containing a phage associated lytic enzyme

Applicant/Assignee: NEW HORIZONS DIAGNOSTICS CORPORATION ROCKEFELLER UNIVERSITY

Application No.: 09/932460   Filing Date: 20/Aug/2001

Abstract:

A composition for treatment of bacterial infections of burns and wounds of the skin, comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, and a carrier for delivering said at least one lytic enzyme to the skin. The carrier may be, but is not limited to, a liquid solution applied to a bandage.

Priority: US2000-671882 Applic. Date: 2000-09-28; US2000-497495 Applic. Date: 2000-04-18; US1999-395636 Applic. Date: 1999-09-14; US1997-962523 Applic. Date: 1997-10-31

Inventor: FISCHETTI VINCENT [US]; LOOMIS LAWRENCE [US]


Patent No.: US6737394B2  Issued: 18/May/2004

Title: Isotropic cleansing composition with benefit agent particles

Applicant/Assignee: UNILEVER HOME AND PERSONAL CARE USA, DIVISION OF CONOPCO, INC UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/090086   Filing Date: 04/Mar/2002

Abstract:

An aqueous isotropic liquid cleansing and moisturizing composition is provided having a surfactant

a thickening agent, and organogel particles with a structure comprising a benefit agent and a gellation agent. In a preferred embodiment the inventive cleansing composition includes a free emollient having a weight average emollient particle size in the range about 1 to about 500 microns.

Priority:

Inventor: SHANA A MAY [US]; VILLA VIRGILIO BARBA [US]


Patent No.: US6740329B2  Issued: 25/May/2004

Title: Process for applying a softening or emollient lotion to a paper product and paper product obtained according to this process

Applicant/Assignee: GEORGIA-PACIFIC FRANCE

Application No.: 09/729224   Filing Date: 05/Dec/2000

Abstract:

The invention provides a process for depositing, at room temperature, a softening lotion on an absorbent paper product, especially cellulose wadding, which lotion is a liquid at room temperature and is of the type comprising one or more emollient active substances as a dispersion or as an emulsion in a volatile liquid vehicle, especially in water, characterized in that it consists in spraying the lotion by means of a stream of gas under pressure so as to remove at least part of the volatile liquid vehicle in order to form and spray fine droplets of lotion, having a low proportion of volatile liquid vehicle, which are deposited on at least one face of the paper product.

Priority: EP19990403111 Applic. Date: 1999-12-10

Inventor: BRET BRUNO [FR]; LEBOEUF JEAN-FRANCOIS [FR]


Patent No.: US6743419B1  Issued: 01/Jun/2004

Title: Method of reducing hair growth employing sulfhydryl active compounds

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 08/869381   Filing Date: 05/Jun/1997

Abstract:

A method of reducing the rate of mammalian hair growth includes topically applying a composition containing a sulfhydryl reactive compound to the skin.

Priority: US1995-414992 Applic. Date: 1995-03-30; US1992-995037 Applic. Date: 1992-12-22

Inventor: SHANDER DOUGLAS [US]; AHLUWALIA GURPREET S [US]; MARKS-DEL GROSSO DIANA [US]


Patent No.: US6743433B2  Issued: 01/Jun/2004

Title: Treatment of acne using alkanolamine compositions

Applicant/Assignee:

Application No.: 10/085864   Filing Date: 27/Feb/2002

Abstract:

Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or glutathione. Adjunct ingredients such as fatty acid esters of ascorbic acid, e.g., ascorbyl palmitate and alpha-hydroxy acids may be included in the formulations. Compositions of the invention may be used alone, or, in many preferable embodiments, in combination with conventional acne medications such as anti-acne products containing salicylic acid, benzoyl peroxide, or a retinoid. In these embodiments, alkanolamine compositions of the invention are applied to affected skin areas first, and then a conventional acne medication is applied. This maximizes the efficacy of the treatment while minimizing skin irritation caused by conventional medications.

Priority: US2001-900680 Applic. Date: 2001-07-06

Inventor: PERRICONE NICHOLAS V [US]


Patent No.: US6743771B2  Issued: 01/Jun/2004

Title: Methods and compositions for controlling protein assembly or aggregation

Applicant/Assignee: NOVACTYL, INC

Application No.: 09/904987   Filing Date: 12/Jul/2001

Abstract:

Compositions and methods for controlling prepathological and pathological protein assembly or aggregation using picolinic acid, analogs, or derivatives thereof are described. The compositions of the invention, capable of solubilizing a conformationally altered protein, comprise a carboxylic acid anion of picolinic acid, its analogs, or derivatives thereof and a cation. According to the methods of the invention, conformationally altered protein assembly or aggregation in an animal is prevented or reversed by introducing the compositions of the invention to the conformationally altered protein. The compositions can be administered systemically by injection, oral administration, inhalation, transdermal, or other routes of administration.

The compositions and methods can be used to treat diseases manifested by conformationally altered protein assembly or aggregation including, but not limited to Alzheimer's disease, spongiform encephalopathy, cerebral amyloid angiopathy, Parkinson's disease, frontal temporal dementia, Pick's disease, amyotrophic lateral sclerosis, Huntington's disease and Creutzfelds-Jakob disease.

Priority: US2000-677500 Applic. Date: 2000-10-02; US2000-657554 Applic. Date: 2000-09-08; US2000-657989 Applic. Date: 2000-09-08; US1998-127620 Applic. Date: 1998-08-01; US1997-843157 Applic. Date: 1997-04-11; US1995-581351 Applic. Date: 1995-12-29; US19960024221P Applic. Date: 1996-10-22; US19960026992P Applic. Date: 1996-09-20

Inventor: DOUGLAS MICHAEL G [US]; AMIN AVINASH N [US]


Patent No.: US6749839B2  Issued: 15/Jun/2004

Title: Photoprotective cosmetic compositions containing aromatic amide, sulphonamide or carbamate derivatives of acrylonitrile and novel aromatic amide, sulphonamide or carbamate derivatives of acrylonitrile

Applicant/Assignee: L'OREAL

Application No.: 10/174485   Filing Date: 19/Jun/2002

Abstract:

Cosmetic compositions for topical use for protecting the skin and the hair, containing, in a cosmetically acceptable support, at least one compound of formula (1) or (2)in which X1 represents R3-(C=O)-, R3-SO2- or R3-O-(C=O)-, X2 represents -(C=O)-R'3-(C=O)-, -SO2-R'3-SO2- or -(C=O)-O-R'3-O-(C=O)-, Y represents -(C=O)-R4 or -SO2R5,R2 represents a C1-8 alkyl group, n is 0, 1 or 2, R3 represents C1-30 alkyl or C3-30 alkenyl, R'3 represents a single bond or a divalent C1-30 alkylene or C3-30 alkenylene radical, R4 represents -OR6 or -NHR6, R5 represents C1-30 alkyl or a phenyl nucleus, R6 represents C1-30 alkyl or C3-30 alkenyl, and novel compounds of formula (2).

Priority: FR20010008092 Applic. Date: 2001-06-20

Inventor: RICHARD HERVE [FR]; LUPPI BERNADETTE [FR]


Patent No.: US6749860B2  Issued: 15/Jun/2004

Title: Absorbent articles with non-aqueous compositions containing botanicals

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 09/747382   Filing Date: 22/Dec/2000

Abstract:

The present invention relates to absorbent articles including non-aqueous compositions for protecting the barrier function of the skin. The compositions can be applied to the bodyfacing surfaces of absorbent articles so that the compositions come into contact with the skin. The compositions of the invention have improved stability on the bodyfacing surfaces after processing. The compositions of the invention provide several benefits including prevention and alleviation of skin irritations associated with the use of absorbent articles. The compositions can include emollients, viscosity enhancers and extracted botanical actives.

Priority:

Inventor: TYRRELL DAVID JOHN [US]; BUHROW CHANTEL SPRING [US]; LANGE BETH ANNE [US]; KRZYSIK DUANE GERARD [US]; BROCK EARL DAVID [US]; CAHALL JAMES LOUIS [US]; LIN SAMUEL QCHENG [US]; WEINKAUF RONNI LYNN [US]; SANTHANAN UMA [US]


Patent No.: US6750253B1  Issued: 15/Jun/2004

Title: Aminobenzophenones as inhibitors of il-1beta and tnf-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS LTD. A/S

Application No.: 10/030970   Filing Date: 22/Feb/2002

Abstract:

The present invention relates to compounds of the formulawherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro, provided that when R1 represents one substituent, it is in the ortho position, and when R1 represents more than one substituent, at least one R1 substituent is in the ortho position

R2 is one substituent in the ortho position, said substituent being selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, phenyl and nitro

R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, phenyl, cyano, carboxy, or carbamoyl

R4 represents hydrogen, (C1-C3)alkyl, or allyl. The compounds are valuable in the human and veterinary therapy.

Priority: WO2000DK00387 Applic. Date: 2000-07-11; US19990144062P Applic. Date: 1999-07-16

Inventor: OTTOSEN ERIK RYTTER [DK]


Patent No.: US6750291B2  Issued: 15/Jun/2004

Title: Film-forming agent for drug delivery and preparation for percutaneous administration containing the same

Applicant/Assignee: PACIFIC CORPORATION

Application No.: 10/121288   Filing Date: 12/Apr/2002

Abstract:

The present invention relates to a film-forming agent which forms a film on the skin, and also to a preparation for percutaneous administration containing the film-forming agent and active ingredient. The transdermal preparation including the film-forming agent of the present invention and active ingredient exhibits excellent elasticity and flexibility, shows superior adhesion power when formed on the skin, and forms non-sticky film.

Priority:

Inventor: KIM YOUNG SO [KR]; CHOI YANG GYU [KR]; KIM JUNG JU [KR]


Patent No.: US6753013B1  Issued: 22/Jun/2004

Title: Pharmaceutical composition

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS, LTD. A/S

Application No.: 09/959367   Filing Date: 22/Oct/2001

Abstract:

A pharmaceutical composition for dermal use, wherein the composition has a first pharmacologically active component A consisting of at least one vitamin D or vitamin D analogue, and a second pharmacologically active component B consisting of at least one corticosteroid, wherein the difference between the maximum stability pH of said first component A and the maximum stability pH of said second component B is at least 1. The composition can also have at least one solvent component C, where component C is compounds of the general formula R<3 >(OCH2C(R<1>)H)xOR<2 >(I), wherein x is in the range of 2-60, R<1 >in each of the x units independently is H or CH3, R<2 >is straight chain or branched C1-20alkyl or benzoyl, and R<3 >is H or phenylcarbonyloxy

di-(straight or branched)-C4-10alkyl esters of C4-C8dicarboxylic acids

straight or branched C12-18-alkyl benzoates

straight or branched C2-4-alkyl esters of straight or branched C10-18-alkanoic or -alkenoic acids

propylenglycol diesters with C8-14-alkanoic acids

and branched primary C18-24alkanols.

Priority: DK19990000561 Applic. Date: 1999-04-23; WO2000DK00033 Applic. Date: 2000-01-27

Inventor: DIDRIKSEN ERIK [DK]; HOEY GERT [DK]


Patent No.: US6756052B1  Issued: 29/Jun/2004

Title: Device and method for increasing the transdermal permeation of medicaments

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/979251   Filing Date: 19/Nov/2001

Abstract:

The invention relates to a device and a method for increasing the transdermal permeation of medications. The invention is characterized in that a constituent which effects a local increase in temperature and/or an increase in blood flow or the skin is administered in a addition to the transdermally applied active substance.

Priority: DE19991023427 Applic. Date: 1999-05-21; WO2000EP04460 Applic. Date: 2000-05-17

Inventor: KOCH ANDREAS [DE]; VON FALKENHAUSEN CHRISTIAN [DE]; MATUSCH RUDOLF [DE]; ADAM BERND [DE]


Patent No.: US6759032B2  Issued: 06/Jul/2004

Title: Antiperspirant compositions containing film-forming polymers

Applicant/Assignee: THE ANDREW JERGENS COMPANY

Application No.: 10/120624   Filing Date: 11/Apr/2002

Abstract:

Antiperspirant compositions for topical application are disclosed. These compositions show improved antiperspirant efficacy, while providing minimized skin residue as well as good skin feel when applied. These antiperspirant compositions comprise an effective amount of an antiperspirant active, from about 10% to about 60% of a topical carrier, and from about 0.5% to about 10% of a non-toxic, water-insoluble, occlusive film-forming polyester polymer.

Priority:

Inventor: MURPHY C SHAWN [US]; BOYLE KRISTIN ANN [US]; ABRUTYN ERIC S [US]


Patent No.: US6759060B2  Issued: 06/Jul/2004

Title: SYNTHETIC PARTICULATE VECTORS AND PREPARATION PROCESS

Applicant/Assignee: BIOVECTOR THERAPEUTICS, S.A

Application No.: 09/112367   Filing Date: 09/Jul/1998

Abstract:

A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical, cosmetological or food compositions containing such vectors are also disclosed.

Priority: WO1994FR00228 Applic. Date: 1994-03-01; FR19930002397 Applic. Date: 1993-03-02; US1996-513853 Applic. Date: 1996-05-01

Inventor: SAMAIN DANIEL [FR]; DE MIGUEL IGANCIO [FR]; N GUYEN FREDERIQUE [FR]; DELRIEU PASCAL [FR]; DING LI [FR]; CANDELOTTO NADINE [FR]; SEGRETO CORINNE [FR]; BETBEDER DIDIER [FR]; KRAVTZOFF ROGER [FR]; MAJOR MICHEL [FR]


Patent No.: US6759443B2  Issued: 06/Jul/2004

Title: Polyurethane foam composition and additive useful in shoe sole applications and methods of making same

Applicant/Assignee: BASF CORPORATION

Application No.: 10/036694   Filing Date: 21/Dec/2001

Abstract:

The invention is directed to polyurethane foam shoe soles containing an additive comprising a mixture of polyethylene wax and PTFE (polytetrafluoroethylene), and to polyol components containing the additive. The additive is produced to include the mixture at a density from greater than 0.97 to about 1.1 times the density of the polyol component.

Priority:

Inventor: BRANT GARY [US]; TODOROSKI DRAGOLJUB [US]


Patent No.: US6764698B1  Issued: 20/Jul/2004

Title: Controlled drug release system of retinoic acid

Applicant/Assignee: KWANGJU INSTITUTE OF SCIENCE & TECHNOLOGY SHIN POONG PHARMACEUTICAL CO., LTD

Application No.: 09/806287   Filing Date: 28/Mar/2001

Abstract:

The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block copolymer having both hydrophilic and hydrophobic groups.

Priority: KR19980041426 Applic. Date: 1998-10-01; WO1999KR00589 Applic. Date: 1999-09-29

Inventor: BYUN YOUNG-RO [KR]; KIM SANG-YOON [KR]; KIM SUN-HEE [KR]; CHOI YONG-DOO [KR]; HAN IN-SUK [US]; LEE KWANG-SUN [KR]; KIM CHUL-HEE [KR]


Patent No.: US6770708B2  Issued: 03/Aug/2004

Title: Silicone elastomers compositions

Applicant/Assignee: DOW CORNING CORPORATION

Application No.: 10/229739   Filing Date: 27/Aug/2002

Abstract:

This invention is directed to an elastomer composition produced by crosslinking a high molecular weight =Si-H containing polysiloxane and a diene, diyne or ene-yne compound in the presence of a diluent. The elastomer composition is suitable for use in forming personal care compositions.

Priority:

Inventor: KADLEC DONALD ANTHONY [US]; LIN ZUCHEN [US]; SCHULZ JR WILLIAM JAMES [US]; SMITH JANET MARY [US]; STARCH MICHAEL STEPHEN [US]; ZHANG SHIZHONG [US]


Patent No.: US6774114B2  Issued: 10/Aug/2004

Title: Topical application of immixture of ascorbic acid + ascorbic acid compounds for augmenting the synthesis of epidermal ceramides

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/425608   Filing Date: 30/Apr/2003

Abstract:

Synergistic immixtures of ascorbic acid with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid more effectively increase the synthesis of epidermal ceramides in human skin, especially types IV to VII ceramides, as well as improve the barrier function, moisture content and/or suppleness/surface appearance of the skin and which otherwise combat/prevent intrinsic aging thereof and are useful for the treatment of dermatitis.

Priority: FR20000004575 Applic. Date: 2000-04-10; US2001-828881 Applic. Date: 2001-04-10

Inventor: CASTIEL ISABELLE [FR]; FERRARIS CORINNE [FR]; LAVALLE-BOUCHARD ARMELLE [FR]


Patent No.: US6774121B1  Issued: 10/Aug/2004

Title: Phospholipid prodrugs of anti-proliferative drugs

Applicant/Assignee: D-PHARM, LTD

Application No.: 10/088160   Filing Date: 13/Mar/2002

Abstract:

The invention discloses prodrugs comprising anti-proliferative drugs covalently linked, via bridging group, to a phospholipid moiety such that the active species is preferentially released, preferably by enzymatic cleavage, at the required site of action. The invention further discloses pharmaceutical compositions said prodrugs and the uses thereof for the treatment of diseases and disorders related to inflammatory, to degenerative or atrophic conditions, and to uncontrolled cell growth. FIG. 1 depicts a graph of animal survival during the course of an experiment wherein mice were i.p. transplanted with 11210 mouse leukemia cells and then treated with vehicle only (squares), MTX (triangles) or molar equivalent dose of DP-MTX071 (circles) according to the regiment described example in Example 11.

Priority: IL19990131887 Applic. Date: 1999-09-14; WO2000IL00562 Applic. Date: 2000-09-13

Inventor: KOZAK ALEXANDER [IL]; SHAPIRO ISRAEL [IL]; VINNIKOVA MARINA [IL]; ERSHOV LEONID [IL]; SENDERIKHIN ALEXANDER [IL]; AYALON ORAN [IL]


Patent No.: US6776980B1  Issued: 17/Aug/2004

Title: Photoprotective/cosmetic compositions comprising dibenzoylmethane/triazine/diphenylacrylate compounds

Applicant/Assignee: L'OREAL

Application No.: 09/099939   Filing Date: 19/Jun/1998

Abstract:

Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) 4-tert-butyl-4'-methoxydibenzoylmethane, (ii) at least one particular 1,3,5-triazine compound, and (iii) at least one alkyl alpha-cyano-beta,beta'-diphenylacrylate, formulated in a cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Priority: FR19960008172 Applic. Date: 1996-07-01; US1997-886245 Applic. Date: 1997-07-01

Inventor: ALLARD DELPHINE [FR]; FORESTIER SERGE [FR]


Patent No.: US6776981B2  Issued: 17/Aug/2004

Title: Personal care product

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 10/059467   Filing Date: 29/Jan/2002

Abstract:

A product for application to skin includes a container having an open end, a non-flowable composition within the container including an application surface at the open end having a visual pattern, and a removable cap having a % opacity of less than 5%.

Priority:

Inventor: ELLIOTT DAVID L [US]; GERSTEN IRIS DAVIS [US]; VAN DER LEE HERMES [US]; SOLAN JAMES L [US]; GUAY GORDON G [US]


Patent No.: US6780402B1  Issued: 24/Aug/2004

Title: Make-up compositions containing phenylated silicone oils, which are resistant to transfer and migration

Applicant/Assignee: L'OREAL

Application No.: 08/643360   Filing Date: 06/May/1996

Abstract:

This application concerns the use of the combination of a volatile oil and a phenylated silicone oil in a composition containing a fatty phase.The invention also relates to a composition containing, in a fatty phase, a volatile oil, a phenylated silicone oil, and less than 20% by weight of a non-volatile hydrocarbonic oil.

Priority: FR19950009254 Applic. Date: 1995-07-28

Inventor: AGOSTINI ISABELLE [FR]; PRADIER FRANCOIS [FR]; ARNAUD PASCAL [FR]


Patent No.: US6780430B2  Issued: 24/Aug/2004

Title: Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same

Applicant/Assignee: PACIFIC CORPORATION

Application No.: 10/120389   Filing Date: 12/Apr/2002

Abstract:

Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and(Wherein,R1, R2 and R3 are H or methyl group, and at least one position selected from the group consisting of the R1, R2 and R3 positions are methyl group

and,A is CH2-CH(CH3)- or CH=C(CH3)-)and an external application for skin containing the stabilized nano-sized emulsion.

Priority: KR20010031360 Applic. Date: 2001-06-05

Inventor: YOO BYUNG HEE [KR]; KIM JOUNG SOO [KR]; KANG BYUNG YOUNG [KR]; KIM KIL JOONG [KR]; HAN SANG HOON [KR]


Patent No.: US6780495B2  Issued: 24/Aug/2004

Title: Complex skin, slush molding thermoplastic elastomer composition for use in the skin, and an article including the skin

Applicant/Assignee: MITSUBOSHI BELTING LTD

Application No.: 10/341115   Filing Date: 13/Jan/2003

Abstract:

A multilayer skin comprising an outer layer prepared by slush molding powder of a thermoplastic elastomer composition having a polypropylene resin, a hydrogenated styrene-butadiene random copolymer rubber, a process oil, an elastomer with high oil absorption capability, and a release agent. An inner layer is bonded to the outer layer, is prepared by slush molding, and is a blend of an elastomer with high oil absorption capability, an olefinic polymer with active hydrogen, and a catalyst which promotes isocyanate reaction. There is also a multilayer skin with a different composition as well as an article made with a multilayer skin having the compositions. There is further a thermoplastic elastomer composition for a layer of a multilayer skin.

Priority: JP19980100787 Applic. Date: 1998-04-13; JP19980102402 Applic. Date: 1998-04-14; JP19980216632 Applic. Date: 1998-07-31; US1999-290796 Applic. Date: 1999-04-13

Inventor: ENAMI HIROHIDE [JP]; ONO KENROU [JP]; KUBOMOTO KENJI [JP]; OKAZAWA TAKAHIDE [JP]


Patent No.: US6780888B1  Issued: 24/Aug/2004

Title: Silicon compounds derived from ascorbic acid

Applicant/Assignee: L'OREAL S.A

Application No.: 10/111537   Filing Date: 24/May/2002

Abstract:

The invention concerns novel silicon compounds derived from ascorbic acid consisting of a silicon-containing chain or of silanes, comprising at least a radical A of formula (I) wherein: at least one of the radicals L is a divalent radical for fixing A on the silicon chain. The invention further concerns methods for preparing said compounds, compositions, in particular cosmetic or pharmaceutical, containing them, and their use as antioxidant and/or anti-free radical agent, particularly for treating oxidant stress, for treating the effects of exposure to the sun and for preventing ageing.

Priority: FR19990013355 Applic. Date: 1999-10-26; WO2000FR02713 Applic. Date: 2000-09-29

Inventor: XU JINZHU [FR]; RICHARD HERVE [FR]


Patent No.: US6783769B1  Issued: 31/Aug/2004

Title: Transdermal therapeutic system TTS containing tolterodine

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/009644   Filing Date: 25/Apr/2002

Abstract:

The invention relates to a transdermal therapeutic system (TTS) for transcutaneously administering tolterodine over a period of several days and to a method for producing the same. The TTS contains a self-adhesive layer-shaped matrix composition which contains a (meth)acrylate copolymer comprising ammonium groups. The TTS also contains at least one plasticizer and up to 25 wt % of tolterodine.

Priority: DE19991022662 Applic. Date: 1999-05-18; WO2000EP04360 Applic. Date: 2000-05-16

Inventor: ARTH CHRISTOPH [DE]; MEESE CLAUS [DE]; SCHACHT DIETRICH WILHELM [DE]; WOLFF HANS-MICHAEL [DE]


Patent No.: US6784145B2  Issued: 31/Aug/2004

Title: Cosmetic and dermatological article

Applicant/Assignee: L'OREAL

Application No.: 10/175378   Filing Date: 20/Jun/2002

Abstract:

The invention relates to an article containing (A) a water-insoluble substrate and (B) containing an aqueous phase and N-(3-chloroallyl)hexaminium chloride. According to one preferred embodiment of the invention, the composition also contains at least one C1-C4 alkyl para hydroxybenzoate and/or at least one ethylenediamine-tetraacetic acid salt. The article may especially constitute a wipe for cleansing and/or removing makeup from the facial and/or body skin, and also for removing makeup from the eyes. The wipe may be in the form of a moist or dry wipe.

Priority: FR20010008284 Applic. Date: 2001-06-22

Inventor: DELAMBRE PATRICIA [FR]; TOUZAN PHILIPPE [FR]; SIMON PASCAL [FR]


Patent No.: US6784169B2  Issued: 31/Aug/2004

Title: MMP inhibitors

Applicant/Assignee: LEO PHARMACETICAL PRODUCTS LTD

Application No.: 10/345304   Filing Date: 16/Jan/2003

Abstract:

Novel compounds according to formula In is 0, 1, 2 or 3

X represents hydroxamic acid (CONHOH), carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group

R2, R10 and R11 independently represent hydrogen or (C1-8)alkyl, (C2-6)alkenyl, (C3-8)cycloalkyl, aryl(C0-6)alkyl or heteroaryl(C0-6)alkyl, all of which may optionally be substituted

R3 and R4 independently represent hydrogen, hydroxy or alkoxy

provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen, and that at least one of R3, R4, R10 and R11 is different from hydrogen

or a salt, hydrate or solvate thereof

pharmaceutical compositions comprising said compound

therapeutical methods comprising administering said compounds

andthe use of said compounds in the manufacture of medicaments.

Priority: US20020349229P Applic. Date: 2002-01-18

Inventor: CHRISTENSEN METTE KNAK [DK]; BLAEHR LARS KRISTIAN ALBERT [DK]


Patent No.: US6787152B2  Issued: 07/Sep/2004

Title: Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof

Applicant/Assignee: TRANSDERMAL TECHNOLOGIES, INC

Application No.: 10/074497   Filing Date: 11/Feb/2002

Abstract:

A transdermal delivery system (TDS) for use in treatment of living bodies may be applied as an open (liquid, gel) or closed (patch) article. The TDS is composed of a particular active agent which dictates an associated selection of certain solvents, solvent modifiers, solute modifiers and skin stabilizers with which the medicament forms a true solution that rapidly crosses the skin barrier. The associated selection of the particular solvents, solvent modifiers, solute modifiers and skin stabilizers is based on a balancing of the molecular properties of all the components against the molecular properties of all the components plus the particular active agent. The TDS may also include a source of cellular energy to induce CAMP or cGMP. The TDS improves delivery of active agents having a molecular weight greater than 340 Daltons and increases dosage above 0.25 mg/day for such active agents.

Priority: US2000-381095 Applic. Date: 2000-05-11; US19980091910P Applic. Date: 1998-07-07

Inventor: KIRBY KENNETH B [US]; PETTERSSON BERNO [US]


Patent No.: US6790454B1  Issued: 14/Sep/2004

Title: Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained

Applicant/Assignee: COLETICA

Application No.: 09/616526   Filing Date: 14/Jul/2000

Abstract:

A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air or a gaseous fluid, or of a very highly compressed collagen sponge. At least one of the two layers, i.e. the porous layer and the essentially compact membrane, may comprise normal, genetically modified or malignant living cells originating particularly from young or elderly subjects. This composite product is used as a collagen support for the manufacture of artificial skin intended especially for performing in vitro tests on the efficacy of potentially active substances or for reconstructing damaged areas of skin in vivo.

Priority: FR20000006743 Applic. Date: 2000-05-26

Inventor: ABDUL MALAK NABIL [FR]; ANDRE VALERIE [FR]; HUC ALAIN [FR]


Patent No.: US6793931B2  Issued: 21/Sep/2004

Title: Ectoparasite asphyxiator compositions and methods for their applications

Applicant/Assignee: SUMMERS LABORATORIES, INC

Application No.: 10/195048   Filing Date: 11/Jul/2002

Abstract:

Water-soluble or water-dispersible, substantially air-impermeable, pharmacologically acceptable, liquid barrier compositions for treating ectoparasite infestations on animal skin and hair, wherein the compositions contain at least one monohydric aralkyl alcohol to prevent the ectoparasites from closing their respiratory systems.

Priority:

Inventor: PRECOPIO MICHAEL J [US]


Patent No.: US6794362B1  Issued: 21/Sep/2004

Title: Asparagine containing elastin peptide analogs

Applicant/Assignee: CONNECTIVE TISSUE IMAGINEERING LLC

Application No.: 09/580893   Filing Date: 30/May/2000

Abstract:

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides or peptide-like compounds having low molecular weights and which substantially correspond to sequences found in elastin. The present composition specifically includes chemical modification of the peptides described herein, specifically carboxy and amino modification including the addition of amino acids to either end of the peptide fragments.

Priority:

Inventor: SANDBERG LAWRENCE B [US]; MITTS THOMAS F [US]; JIMENEZ JR FELIPE [US]


Patent No.: US6795462B1  Issued: 21/Sep/2004

Title: Gas laser

Applicant/Assignee:

Application No.: 10/019638   Filing Date: 12/Apr/2002

Abstract:

The invention describes a gas laser comprising a container (6) intended to receive a gas or a gas mixture as laser-active medium, the container (6) having an axis (14) along which the gas laser emits its laser radiation, and comprising further means for generating a plasma in the container (6) and means for generating a magnetic field in the container (6). It is provided according to the invention that a group of at least two pairs of magnet poles is arranged, with the poles (1, 2) extending at a distance from, and along the axis (14) and being arranged around the axis (14) with alternating polarity so that the magnetic field emanating from them exhibits an intensity sink in the region of the axis (14), and that the means for generating the plasma include a source for an electromagnetic alternating field, which is associated to the container (6).

Priority: DE19991030755 Applic. Date: 1999-07-02; WO2000EP06195 Applic. Date: 2000-07-03

Inventor: CHRISTIANSEN JENS [DE]; CHRISTIANSEN KAI [DE]; JACOBY JOACHIM [DE]; CHRISTIANSEN SILKE [DE]


Patent No.: US6797286B2  Issued: 28/Sep/2004

Title: Methods and preparations of extracts of Uncaria species with reduced alkaloid content

Applicant/Assignee: RAINFOREST NUTRITIONALS, INC

Application No.: 10/674986   Filing Date: 30/Sep/2003

Abstract:

The method herein describes a process for the preparation and extraction of components from plants of the family Rubiaceae indigenous to South America, also known as Cat's Claw or Uv±a de gato. Cat's claw is an ethnomedicine that contains a variety of constituents, some of which have opposing actions. Oxindole and pentacyclic alkaloids have been proposed to be constituents that stimulate immune function, whereas polar constituents act to suppress immune response. An extract that was devoid of the aforementioned alkaloids would avoid opposing actions that may negate effectiveness or limit therapeutic outcome.

Priority: US20020416730P Applic. Date: 2002-10-05

Inventor: BOBROWSKI PAUL J [US]


Patent No.: US6801804B2  Issued: 05/Oct/2004

Title: Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis

Applicant/Assignee: ACIONT, INC

Application No.: 10/138723   Filing Date: 03/May/2002

Abstract:

The invention provides a device for iontophoretically transporting a compound through a localized region of an individual's body tissue. The device comprises first and second iontophoretic electrodes, a reference electrode, a current source, and a monitoring means. The first electrode is placed in ion-conducting relation with the localized region to allow iontophoretic transport of a compound therethrough. The second and transport electrodes are each placed in contact with the individual's body tissue, and all electrodes are spaced apart from each other. The current source is electrically connected to the first and second electrodes and applies a current to the localized region of body tissue to effect iontophoretic transport.

The monitoring means monitors the electrical resistance of the localized region by measuring any voltage difference between the reference electrode and the first and/or second electrodes. Methods for using a reference electrode to monitor and control iontophoresis are also provided.

Priority:

Inventor: MILLER DAVID J [US]; HIGUCHI WILLIAM I [US]; LI KEVIN [US]; HASTINGS MATTHEW S [US]


Patent No.: US6803047B1  Issued: 12/Oct/2004

Title: Vaporizable gelled composition

Applicant/Assignee: L'OREAL

Application No.: 09/380888   Filing Date: 27/Oct/1999

Abstract:

A topical composition containing an aqueous gel which contains a hydrophilic gelling material, wherein the gel has at least one of the following properties: an initial viscosity V0 ranging from 3000 to 50,000 Pa.s, wherein the initial viscosity is stable up to a shear strain C1, a viscosity V2 after shear at a strain C2, wherein a ratio of V0/V2 is greater than or equal to 1000, and a difference of C2-C1 is less than or equal to 100 Pa.

Priority: FR19970003118 Applic. Date: 1997-03-14; WO1998FR00423 Applic. Date: 1998-03-04

Inventor: DUPUIS CHRISTINE [FR]


Patent No.: US6805856B2  Issued: 19/Oct/2004

Title: Hair care compositions which reduce color loss in hair and methods of using the compositions

Applicant/Assignee: L'OREAL

Application No.: 10/123208   Filing Date: 17/Apr/2002

Abstract:

The present invention provides hair care compositions comprising at least 10% of one or more polydialkylsiloxanes each having at least one pendant alkyl moiety, methods of using the compositions to reduce the loss of color in the hair, methods of using the compositions to reduce the effects of oxidation on the hair, and methods of using the compositions to add volume to the hair.

Priority:

Inventor: WONG MIKE [US]; MEMISHA EVA [US]


Patent No.: US6806070B1  Issued: 19/Oct/2004

Title: Use of bacterial extracts of the pseudomonadaceae family as cosmetic agents

Applicant/Assignee: L'OREAL

Application No.: 10/049552   Filing Date: 18/Apr/2002

Abstract:

Use of an extract of bacterium from the family Pseudomonadaceae in the production of cosmetic compositions in particular for combating ageing of the skin.

Priority: WO1999FR02043 Applic. Date: 1999-08-26; FR19980002186 Applic. Date: 1998-02-24

Inventor: MARTIN RICHARD [FR]; HILAIRE PASCAL [FR]; PINEAU NATHALIE [FR]; BRETON LIONEL [FR]


Patent No.: US6811770B2  Issued: 02/Nov/2004

Title: Two-coat make-up process and a make-up kit containing first and second compositions

Applicant/Assignee: L'OREAL

Application No.: 10/118949   Filing Date: 10/Apr/2002

Abstract:

A process for cosmetically making-up the skin and/or the lips and/or integuments of a human being, which comprises:applying to the skin, the lips and/or integuments a first coat of a first composition comprising, in a first physiologically acceptable medium, dispersed polymer particles surface-stabilized with a stabilizer in a liquid phase

permitting the first coat to dry

and thenapplying over all or a part of the first coat, a second coat of a second composition comprising, in a second physiologically acceptable medium, a silicone-based and/or fluoro-based liquid phase.

Priority: FR20010004940 Applic. Date: 2001-04-10; FR20020001444 Applic. Date: 2002-02-06; US20010293980P Applic. Date: 2001-05-30

Inventor: FERRARI VERONIQUE [FR]; LEBRE CAROLINE [FR]; ARNAUD PASCAL [FR]


Patent No.: US6812192B2  Issued: 02/Nov/2004

Title: Foaming cosmetic compositions, uses for cleansing or make-up removal

Applicant/Assignee: L'OREAL S.A

Application No.: 10/400580   Filing Date: 28/Mar/2003

Abstract:

A foaming composition for topical application, comprising at least one surfactant system comprising at least one fatty acid chosen from partially and completely neutralized fatty acids, at least one non-betaine amphoteric co-surfactant and at least one anionic co-surfactant of the sulphosuccinate type and its use in the cosmetic or dermatological fields, for example, as cleansing and/or make-up-removing products for a human keratinous material, for example, the skin.

Priority: FR20020003929 Applic. Date: 2002-03-28; US20020382564P Applic. Date: 2002-05-24

Inventor: RIBERY DELPHINE [FR]; BISSEY-BEUGRAS LAURE [FR]


Patent No.: US6818206B2  Issued: 16/Nov/2004

Title: USE OF AMPHIPHILIC COPOLYMERS TO STABILIZE DISPERSIONS OF INSOLUBLE ORGANIC COMPOUNDS FOR SCREENING OUT UV RADIATION, DISPERSIONS STABILIZED WITH THESE COPOLYMERS AND COSMETIC COMPOSITIONS CONTAINING THEM

Applicant/Assignee: L'OREAL

Application No.: 10/268081   Filing Date: 10/Oct/2002

Abstract:

The invention relates to the use of at least one amphiphilic copolymer comprising at least one hydrophilic block and at least one hydrophobic block to stabilize dispersions of insoluble organic compounds comprising at least one group that absorbs UV radiation, which is in the form of particles with a mean size of between 10 nm and 5 mum, and also to dispersions stabilized with these amphiphilic copolymers and to cosmetic compositions for topical application, in particular antisun compositions, containing them.

Priority: FR20010013114 Applic. Date: 2001-10-11

Inventor: CANDAU DIDIER [FR]; AUBERT FABIEN [FR]


Patent No.: US6821523B2  Issued: 23/Nov/2004

Title: Topical administration of pharmacologically active bases in the treatment of warts

Applicant/Assignee: DERMATRENDS, INC

Application No.: 10/176963   Filing Date: 21/Jun/2002

Abstract:

Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat human papilloma virus infections, particularly cutaneous warts.

Priority:

Inventor: MAIBACH HOWARD I [US]; LUO ERIC C [US]; HSU TSUNG-MIN [US]


Patent No.: US6821942B2  Issued: 23/Nov/2004

Title: Cosmetic cleansing composition

Applicant/Assignee: L' OREAL L'OREAL

Application No.: 09/903769   Filing Date: 13/Jul/2001

Abstract:

A cleansing composition, comprising (1) at least one foaming surfactant, (2) at least one hydrophobic silica and (3) at least one oxyalkylenated compound in a physiologically acceptable aqueous medium comprising at least 35% by weight of water relative to the total weight of the composition.

Priority: FR20000009226 Applic. Date: 2000-07-13

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]; GUILLOU VERONIQUE [FR]


Patent No.: US6825161B2  Issued: 30/Nov/2004

Title: Multi component controlled delivery system for soap bars

Applicant/Assignee: SALVONA LLC

Application No.: 10/286143   Filing Date: 01/Nov/2002

Abstract:

The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin.

The high cationic charge density on the nanosphere surface is created by incorporating a cationic conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a cationic charge "booster" in the moisture sensitive microsphere matrix, or by using a cationic conditioning agent in the nanosphere matrix in conjunction with a cationic charge "booster" in the microsphere matrix. The invention also pertains to soap products comprising the controlled release system of the present invention.

Priority: US2002-133833 Applic. Date: 2002-04-26

Inventor: SHEFER ADI [US]; SHEFER SAMUEL [US]


Patent No.: US6825179B2  Issued: 30/Nov/2004

Title: Active ingredient combinations or adducts of cyclodextrins and quinones

Applicant/Assignee: BEIERSDORF AG

Application No.: 09/907171   Filing Date: 17/Jul/2001

Abstract:

Active ingredient combinations of cyclodextrins and at least one quinone and/or at least one hydroquinone for use in cosmetic or dermatological formulations.

Priority: DE20001035513 Applic. Date: 2000-07-21

Inventor: NIELSEN JENS [DE]; MAX HEINER [DE]; HARGENS BIRGIT [DE]; SCHIMPF RALPH [DE]


Patent No.: US6827944B2  Issued: 07/Dec/2004

Title: Percutaneous administration preparations

Applicant/Assignee: KAO CORPORATION

Application No.: 09/926394   Filing Date: 25/Oct/2001

Abstract:

Provided is a composition for percutaneous administration containing a mixture of polymers forming a surface-segregated film, and (B) an active ingredient. The composition provides excellent percutaneous absorption efficacy of the active ingredient, particularly, a water-soluble active ingredient, has excellent feeling and is convenient to use.

Priority: JP20000053095 Applic. Date: 2000-02-29; WO2001JP01345 Applic. Date: 2001-02-23

Inventor: HOSOKAWA MASARU [JP]; SHIMIZU KUMIKO [JP]; UESAKA TOSHIO [JP]; SUGAI ICHIRO [JP]; MORI SHINOBU [JP]


Patent No.: US6838078B2  Issued: 04/Jan/2005

Title: Film-forming compositions and methods

Applicant/Assignee:

Application No.: US 2002-052158   Filing Date: 16/Jan/2002

Abstract: US 6838078 B2 20050104 US6838078 20050104 US20020052158 20020116 US20020052158 20020116 3M INNOVATIVE PROPERTIES CO [US] WANG DANLI [US] SCHOLZ MATTHEW T [US] ZHU DONG-WEI [US] LU TRIET M [US] Film-forming compositions and methods

Priority:

Inventor: WANG DANLI [US]; SCHOLZ MATTHEW T [US]; ZHU DONG-WEI [US]; LU TRIET M [US]


Patent No.: US6838493B2  Issued: 04/Jan/2005

Title: Medical devices and applications of polyhydroxyalkanoate polymers

Applicant/Assignee: METABOLIX, INC

Application No.: 10/082954   Filing Date: 26/Feb/2002

Abstract:

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes,

bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Priority: US2000-535146 Applic. Date: 2000-03-24; US19990142238P Applic. Date: 1999-07-02; US19990126180P Applic. Date: 1999-03-25

Inventor: WILLIAMS SIMON F [US]; MARTIN DAVID P [US]; SKRALY FRANK A [US]


Patent No.: US6838541B2  Issued: 04/Jan/2005

Title: Method of making siloxane-based polyamide elastomers

Applicant/Assignee:

Application No.: 10/365851   Filing Date: 12/Feb/2003

Abstract: US 6838541 B2 20050104 US6838541 20050104 US20030365851 20030212 10365851 US20030365851 20030212 DOW CORNING [US] LIN ZUCHEN, NGUYEN KIMMAI THI, PETROFF LENIN JAMES LIN ZUCHEN [US] NGUYEN KIMMAI THI [US] PETROFF LENIN JAMES [US] LIN ZUCHEN, NGUYEN KIMMAI THI, PETROFF LENIN JAMES Method of making siloxane-based polyamide elastomers

Priority:

Inventor: LIN ZUCHEN [US]; NGUYEN KIMMAI THI [US]; PETROFF LENIN JAMES [US]


Patent No.: US6841162B2  Issued: 11/Jan/2005

Title: Cosmetic or dermatological composition contacting at least one natural or recombinant spider silk or an analog

Applicant/Assignee: L' OREAL L'OREAL

Application No.: 09/861597   Filing Date: 22/May/2001

Abstract:

A cosmetic or dermatological composition containing, as an active substance, at least one natural or recombinant spider silk protein, or an analog of such a protein. The composition may be in the form of hair products, skincare products, make-up products or antisun products.

Priority: FR19980001614 Applic. Date: 1998-02-11; US1999-247806 Applic. Date: 1999-02-11

Inventor: PHILIPPE MICHEL [FR]; GARSON JEAN-CLAUDE [FR]; ARRAUDEAU JEAN-PIERRE [FR]


Patent No.: US6843980B2  Issued: 18/Jan/2005

Title: Methods for using annexin for detecting cell death in vivo and treating associated conditions

Applicant/Assignee: THESUS IMAGING CORPORATION THESEUS IMAGING, CORP

Application No.: 10/114927   Filing Date: 03/Apr/2002

Abstract:

The present invention provides methods and compositions for imaging cell death in vivo, as well as methods and compositions for tumor radiotherapy.

Priority: US20010281277P Applic. Date: 2001-04-03

Inventor: GREEN ALLAN M [US]


Patent No.: US6846479B2  Issued: 25/Jan/2005

Title: Sunscreen compositions comprising mineral oxides having hydrophobic coatings and glycoside-substituted polydimethylsiloxanes

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/448345   Filing Date: 30/May/2003

Abstract:

Stable, topically applicable cosmetic/dermatological compositions, notably W/O emulsions, well suited for the UV-photoprotection of the skin, lips and/or the hair, and/or for the makeup of the skin and/or the lips, contain a thus effective amount of at least one mineral oxide having a hydrophobic coating thereon, e.g., coated particulates of an oxide of titanium and/or zinc, and, as a stabilizing agent therefor, a thus effective amount of at least one oxyalkylenated polydimethylsiloxane bearing at least one glycoside residue substituent, formulated into a physiologically acceptable medium therefor.

Priority: FR20000015517 Applic. Date: 2000-11-30; WO2001FR03603 Applic. Date: 2001-11-16

Inventor: LORANT RALUCA [FR]; LENNON PAULA [FR]


Patent No.: US6846812B2  Issued: 25/Jan/2005

Title: 7-oxo-DHEA compounds for treating keratinous conditions/afflictions

Applicant/Assignee: L'OREAL

Application No.: 10/170679   Filing Date: 14/Jun/2002

Abstract:

7-Oxo-DHEA derivatives, various of which are themselves novel compounds, are well suited for cosmetically/therapeutically treating adverse conditions/afflictions of a keratinous substrate/material, notably of human skin, hair, eyelashes and nails, to improve the appearance thereof, in particular to prevent or treat signs of aging of the skin and/or a dull complexion and/or skin or hair pigmentation disorders and/or dryness of the skin and/or hyperseborrhoea and/or hyperseborrhoea-related imperfections and/or sensitive skin and/or dandruff and/or natural hair loss and/or baldness.

Priority: FR20010007804 Applic. Date: 2001-06-14

Inventor: DALKO MARIA [FR]; CAVEZZA ALEXANDRE [FR]; PICARD-LESBOUEYRIES ELISABETH [FR]; RENAULT BEATRICE [FR]; BURNIER VERONIQUE [FR]


Patent No.: US6846837B2  Issued: 25/Jan/2005

Title: Topical administration of basic antifungal compositions to treat fungal infections of the nails

Applicant/Assignee:

Application No.: 10/178074   Filing Date: 21/Jun/2002

Abstract:

Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.

Priority:

Inventor: MAIBACH HOWARD I [US]; LUO ERIC C [US]; HSU TSUNG-MIN [US]


Patent No.: US6846940B2  Issued: 25/Jan/2005

Title: Ceramides, compositions thereof and methods of use thereof

Applicant/Assignee: L'OREAL

Application No.: 10/347448   Filing Date: 21/Jan/2003

Abstract:

Novel ceramide compounds, compositions containing them and the use of these compounds, in particular for strengthening the lipid barrier of the epidermis.

Priority: FR20020000760 Applic. Date: 2002-01-22; US20020352276P Applic. Date: 2002-01-30

Inventor: GAETANI QUINTINO [FR]; GUEY CHRISTELE [FR]; ARBEY ERIC [FR]; CASTIEL ISABELLE [FR]


Patent No.: US6849250B2  Issued: 01/Feb/2005

Title: Synergistically high SPF photoprotective UV-screening compositions comprising benzotriazole-substituted silicon/dibenzoylmethane/diarylbutadiene compounds

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/463340   Filing Date: 18/Jun/2003

Abstract:

Topically applicable, enhanced SPF cosmetic/dermatological UV-screening compositions suited for the photoprotection of the skin and/or hair, comprise, (i) at least one UV-screening benzotriazole-substituted silicon compound, as a first screening agent

(ii) at least one UV-screening dibenzoylmethane compound, as a second screening agent

(iii) at least one 4,4-diarylbutadiene compound, as a third screening agent, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle therefor.

Priority: FR20000016519 Applic. Date: 2000-12-18; WO2001FR03634 Applic. Date: 2001-11-20

Inventor: CANDAU DIDIER [FR]


Patent No.: US6852403B2  Issued: 08/Feb/2005

Title: Decorative components having an elastomeric outer surface and methods of making such components

Applicant/Assignee: BASF CORPORATION

Application No.: 10/668759   Filing Date: 23/Sep/2003

Abstract:

The aromatic polyurethane elastomers of the present invention are particularly suited for methods of making objects in a mold cavity. The objects generally include an elastomeric layer formed from an aromatic polyurethane and a foam layer which is subsequently applied to the elastomer. The aromatic elastomer of the present invention lends itself to being precoated with an in-mold coating or being painted after demolding the resulting part.

Priority: US2002-174483 Applic. Date: 2002-06-18; US1998-124328 Applic. Date: 1998-07-29

Inventor: HARRISON RICHARD P [US]; OGONOWSKI JOSEPH [US]; PAVLINAC JON P [US]; CHANG L PATRICK [US]


Patent No.: US6852699B1  Issued: 08/Feb/2005

Title: COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING OLIGOPEPTIDES FOR LIGHTENING THE SKIN OF AGE MARKS AND/OR FOR PREVENTING TANNING OF THE SKIN, IN PARTICULAR TANNING OF THE SKIN CAUSED BY UV RADIATION

Applicant/Assignee: BEIERSDORF AG

Application No.: 10/223526   Filing Date: 19/Aug/2002

Abstract:

Cosmetic or pharmaceutical preparations which are distinguished by an effective content of one or more monomeric or homo- or heterodimeric or homo- or heterotrimeric or homo- or heterotetrameric oligopeptides, where these oligopeptides are based on a structure Val-Val-Arg-Pro as homo- or heteromonomer.

Priority: US1998-132799 Applic. Date: 1998-08-13

Inventor: SCHOENROCK UWE [DE]; MAX HEINER [DE]; HEARING VINCENT J [US]


Patent No.: US6852815B1  Issued: 08/Feb/2005

Title: Conditioning/styling tetrapolymers

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 10/848101   Filing Date: 18/May/2004

Abstract:

What is described herein are conditioning/styling tetrapolymers of vinyl caprolactam (VCL), vinylpyrrolidone (VP), dimethylaminopropyl methacrylamide (DMAPMA) and C8-C24 alkyl quaternized dimethylaminopropyl (meth)acrylamide or methacrylic acid quaternized monomers (QDMAPMA), in a defined compositional range. Hair and skin care compositions which include these tetrapolymers exhibit advantageous low tackiness and high humidity resistance.

Priority:

Inventor: CHUANG JUI-CHANG [US]; JACHOWICZ JANUSZ [US]; WINKLER THOMAS [US]; KRAUSS ALLEN J [US]


Patent No.: US6855311B2  Issued: 15/Feb/2005

Title: Photoprotective cosmetic compositions comprising inorganic UV-blocking agents

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/618701   Filing Date: 15/Jul/2003

Abstract:

Stable photoprotective cosmetic emulsions, notably water-in-oil emulsions well suited for the UV-photoprotection of the skin, lips, mucous membranes and/or hair, contain at least one aqueous phase, at least one oily phase, an effective UV-photoprotecting amount of at least one coated or uncoated metal oxide UV-blocking agent and an effective stabilizing amount of at least one amphiphilic oligomer or polymer derived from a polyolefin which also comprises at least one polar moiety, formulated into a physiologically acceptable medium therefor.

Priority: FR20010000484 Applic. Date: 2001-01-15; WO2002FR00046 Applic. Date: 2002-01-08

Inventor: LENNON PAULA [FR]; LORANT RALUCA [FR]


Patent No.: US6858200B2  Issued: 22/Feb/2005

Title: Sunscreen formulations

Applicant/Assignee: SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC SCHERING-PLOUGH HEALTHCARE HEALTHCARE PRODUCTS INC

Application No.: 10/164720   Filing Date: 06/Jun/2002

Abstract:

Disclosed are formulations for topical application, the formulation comprising a C15 branched polyalphaolefin, an aqueous phase, a non-aqueous phase, and at least one sunscreen active agent, alone or in combination with an insect repellant.

Priority: US20010296433P Applic. Date: 2001-06-06

Inventor: FOWLER KEVIN [US]


Patent No.: US6858206B2  Issued: 22/Feb/2005

Title: Methods for treating diseases caused by deficiencies of recombinant alpha-L-iduronidase

Applicant/Assignee:

Application No.: 09/993241   Filing Date: 13/Nov/2001

Abstract:

The present invention provides a formulation comprising a pharmaceutical composition comprising a human recombinant alpha-L-iduronidase or biologically active or muteins thereof with a purity of greater than 99%, or in combination with a pharmaceutically acceptable carrier. The present invention further provides methods to treat certain genetic disorders including alpha-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1) by administering said formulation.

Priority: US2000-711205 Applic. Date: 2000-11-09; US1999-439923 Applic. Date: 1999-11-12

Inventor: KAKKIS EMIL D [US]


Patent No.: US6861062B2  Issued: 01/Mar/2005

Title: Skin cream

Applicant/Assignee:

Application No.: 10/167352   Filing Date: 12/Jun/2002

Abstract:

A skin cream is presented which reduces wrinkles upon topical application to the skin. The main ingredients of the composition include water and a xanthine based compound composition which is mixed together in a first vessel and a glycerin composition heated in a second vessel. The three components of the active ingredient are mixed carefully, making sure that any precipitate produced is remixed into the solution. After heating and mixing the components, the entire composition is cooled with care being taken to push any precipitate back into solution to ensure an even distribution of all of the components. The active ingredient thus produced may be combined with a suitable pharmaceutical vehicle to provide the topical wrinkle reducing moisturizing and protecting composition.

The composition is topically applied to the effected area over a period of days or months in order to reduce or entirely eliminate wrinkles and dryness from the skin. The final active ingredient may also be used for other applications.

Priority: US2000-516325 Applic. Date: 2000-03-01

Inventor: SILVA VICTOR [US]; SZCZESIUL ANDREW [US]; RUDROFF GREGORY [US]


Patent No.: US6861078B2  Issued: 01/Mar/2005

Title: Plant extracts with anti-radical type action

Applicant/Assignee: COGNIS FRANCE (SOCIETE ANONYME)

Application No.: 10/307977   Filing Date: 03/Dec/2002

Abstract:

The use of plant extracts, especially plant extracts with an anti-radical-type action, and a cosmetic or dermo-pharmaceutical composition containing extracts of this type. The use of at least one plant extract whose botanical genus belongs to the group formed by the following: Clidemia, Inga, Sabicea, Astrocaryum, Siparuna, Eperua, Byrsonima, Priva, Coutoubea and Goupia genera

as an active substance which has especially anti-radical-type activities, for preparing a cosmetic or dermopharmaceutical product for local, external use for the skin, the mucous membranes and/or the epithet or appendage structures.

Priority: FR19980015380 Applic. Date: 1998-12-03; US2001-857445 Applic. Date: 2001-06-04

Inventor: PAULY GILLES [FR]; MORETTI CHRISTIAN [FR]


Patent No.: US6861083B2  Issued: 01/Mar/2005

Title: Process and apparatus for the integral utilization of oil-producing drupes, particularly olives, and specific products obtained

Applicant/Assignee:

Application No.: 09/998710   Filing Date: 30/Nov/2001

Abstract:

A process and an apparatus for the processing of oil-producing drupes, notably olives, is described comprising at least one device (20, 24) for the processing of whole drupes which effects a physical destructuring with incipient detachment of the drupe pulp from the skins and stones, under conditions which substantially avoid the oxidation mainly of the pulp's natural antioxidants

at least one device (42, 52

110

120, 124, 130, 134, 160, 170) for the physical separation and recovery (at 100) of the pulp essentially devoid of stones and advantageously skins, and (at 92, 96, 110) of the stones essentially devoid of pulp, advantageously with the skins, ly under conditions which substantially avoid oxidation

and at least one device (160, 170, 172, 174) for the separation and recovery of the pulp oil essentially devoid of stone oil and containing the pulp's natural antioxidants, thereby improving the purity and oxidation resistance of the pulp oil.

Priority: FR20000015558 Applic. Date: 2000-12-01

Inventor: MARTEL JEAN-PIERRE [FR]; FARCOT OLIVIER [FR]


Patent No.: US6861397B2  Issued: 01/Mar/2005

Title: Compositions having enhanced deposition of a topically active compound on a surface

Applicant/Assignee: THE DIAL CORPORATION

Application No.: 10/192449   Filing Date: 10/Jul/2002

Abstract:

Topically active compositions having enhanced effectiveness are disclosed. The compositions contain a topically active compound, an anionic surfactant, a hydric solvent, a hydrotrope, an optional cosurfactant, and water, wherein a percent saturation of the topical active compound of the composition is at least 25%. The compositions exhibit a rapid and effective topical effect, and effectively deposit the topically active compound for an effective residual effect.

Priority: US2000-578020 Applic. Date: 2000-05-24; US1999-338654 Applic. Date: 1999-06-23

Inventor: SEITZ JR EARL P [US]; WAGGONER ANDREA LYNN [US]; FOX PRISCILLA S [US]; TAYLOR TIMOTHY J [US]


Patent No.: US6867179B1  Issued: 15/Mar/2005

Title: Methods of inducing hair growth and coloration

Applicant/Assignee: TRUSTEES OF BOSTON UNIVERSITY

Application No.: 09/632748   Filing Date: 04/Aug/2000

Abstract:

Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.

Priority: WO1999US02362 Applic. Date: 1999-02-03; US1998-018194 Applic. Date: 1998-02-04; US1997-793683 Applic. Date: 1997-04-03; US1994-298941 Applic. Date: 1994-08-31; WO1995US10971 Applic. Date: 1995-08-30

Inventor: GILCHREST BARBARA A [US]; YAAR MINA [US]; ELLER MARK [US]


Patent No.: US6867229B2  Issued: 15/Mar/2005

Title: Antiparasitic composition for the treatment and protection of pets

Applicant/Assignee: MERIAL

Application No.: 10/118404   Filing Date: 08/Apr/2002

Abstract:

Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution:a) an insecticidal active substance of formula (I),b) a crystallization inhibitor,c) an organic solvent having a dielectric constant of between 10 and 35, preferably of between 20 and 30,d) an organic co-solvent having a boiling point below 100 DEG C., preferably below 80 DEG C., and a dielectric constant of between 10 and 40, preferably of between 20 and 30.

Priority: FR19950011685 Applic. Date: 1995-09-29; FR19960011278 Applic. Date: 1996-09-11; US1996-719942 Applic. Date: 1996-09-25

Inventor: ETCHEGARAY JEAN PIERRE [FR]


Patent No.: US6867247B2  Issued: 15/Mar/2005

Title: Medical devices and applications of polyhydroxyalkanoate polymers

Applicant/Assignee: METABOLIX, INC

Application No.: 10/136499   Filing Date: 01/May/2002

Abstract:

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes,

bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Priority: US2000-535146 Applic. Date: 2000-03-24; US19990142238P Applic. Date: 1999-07-02; US19990126180P Applic. Date: 1999-03-25

Inventor: WILLIAMS SIMON F [US]; MARTIN DAVID P [US]; SKRALY FRANK A [US]


Patent No.: US6869597B2  Issued: 22/Mar/2005

Title: Cosmetic care or makeup composition for a keratin material comprising at least one photoprotective agent and at least one ester comprising an aromatic group

Applicant/Assignee: L'OREAL L'OREAL S.A

Application No.: 10/138299   Filing Date: 06/May/2002

Abstract:

A cosmetic care or makeup composition for keratin materials comprising, in a physiologically acceptable medium, at least one photoprotective agent capable of screening out UV radiation and at least one ester comprising an aromatic group, which is liquid at room temperature, resulting from the esterification of an aromatic acid with at least one hydroxyl group chosen from pendent hydroxyl groups and terminal hydroxyl groups of hydroxylated aliphatic compounds, said hydroxylated aliphatic compounds being chosen from hydroxylated aliphatic acids and esters thereof. Use of the said ester comprising an aromatic group to improve the photoprotective power of compositions intended for protecting the skin and/or the lips and/or integuments against UV radiation.

Priority: FR20010006048 Applic. Date: 2001-05-04

Inventor: ARNAUD PASCAL [FR]


Patent No.: US6872400B2  Issued: 29/Mar/2005

Title: Composition with a continuous aqueous phase containing L-2-oxothiazolidine-4-carboxylic acid

Applicant/Assignee: L'OREAL

Application No.: 10/002959   Filing Date: 05/Dec/2001

Abstract:

A composition containing a continuous aqueous phase comprising L-2-oxothiazolidine-4-carboxylic acid, at least one sequestering agent and at least one neutralizing agent, the said neutralizing agent being present in an amount which is sufficient to adjust the pH of the aqueous phase of the composition to a value of between 5 and 8. The combination of the sequestering agent and the neutralizing agent stabilizes the L-2-oxothiazolidine-4-carboxylic acid, in particular with respect to thermal degradation, and thus prevents yellowing of the composition and the formation of unpleasant odors.

Priority: FR19990003476 Applic. Date: 1999-03-19; US2000-522106 Applic. Date: 2000-03-09

Inventor: CHEVALIER VERONIQUE [FR]; QUEST MELANIE [FR]


Patent No.: US6875426B2  Issued: 05/Apr/2005

Title: Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/400551   Filing Date: 28/Mar/2003

Abstract:

The present invention relates to a cosmetic and/or dermatological composition more particularly intended for artificially tanning and/or browning the skin and comprising, in a cosmetically acceptable support, at least one derivative or a mixture of derivatives of 1,7-bisphenyl heptane-3,5-dione of particular structure and at least one self-tanning agent.The present invention also relates to a cosmetic treatment process for artificially tanning or browning the skin and to the use of at least one derivative or a mixture of derivatives of 1,7-bisphenyl heptane-3,5-dione of particular structure for improving the coloration and/or stability of a self-tanning agent.The invention also relates to the uses of these compositions for giving the skin a coloration close to that of a natural skin tan.

Priority: FR20020003934 Applic. Date: 2002-03-28; US20020377958P Applic. Date: 2002-05-07

Inventor: CANDAU DIDIER [FR]


Patent No.: US6875748B2  Issued: 05/Apr/2005

Title: Compositions and methods for in vivo delivery of polynucleotide-based therapeutics

Applicant/Assignee: VICAL INCORPORATED

Application No.: 09/839574   Filing Date: 23/Apr/2001

Abstract:

The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provides the use of salts, in particular sodium and potassium salts of phosphate, in aqueous solution, and auxiliary agents, in particular detergents and surfactants, in pharmaceutical compositions and methods useful for direct polynucleotide-based polypeptide delivery into the cells of vertebrates.

Priority: US20000198823P Applic. Date: 2000-04-21; US20000253153P Applic. Date: 2000-11-28

Inventor: MANTHORPE MARSTON [US]; HARTIKKA JUKKA [US]; SUKHU LORETTA [US]; MEEK JENNIFER [US]


Patent No.: US6875754B1  Issued: 05/Apr/2005

Title: Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skin treatment agents

Applicant/Assignee: BIOTEC ASA

Application No.: 09/936748   Filing Date: 04/Feb/2002

Abstract:

The invention relates to the use of water soluble beta-(1,3) glucans, which are essentially free from (1,6) links as active ingredients agents for producing therapeutic skin treatment agents. Said products strengthen the skin's immune system, counteract the formation of wrinkles and can be used to treat psoriasis and eczemic conditions.

Priority: DE19991011054 Applic. Date: 1999-03-12; WO2000EP01830 Applic. Date: 2000-03-03

Inventor: GRIESBACH UTE [DE]; WACHTER ROLF [DE]; ANSMANN ACHIM [DE]; FABRY BERND [DE]; ENGSTAD ROLF E [NO]


Patent No.: US6878381B2  Issued: 12/Apr/2005

Title: Resorcinol composition

Applicant/Assignee: PFIZER, INC

Application No.: 10/061040   Filing Date: 30/Jan/2002

Abstract:

The present invention relates to the use of a resorcinol derivative, i.e., 4-(2,4-dihydroxyphenyl)cyclohexanol, or a pharmaceutically acceptable salt thereof, as a skin lightening agent.

Priority: US2000-525643 Applic. Date: 2000-03-15; US19990125553P Applic. Date: 1999-03-22

Inventor: COLLINGTON ERIC WILLIAM [GB]


Patent No.: US6878518B2  Issued: 12/Apr/2005

Title: Methods for determining steroid responsiveness

Applicant/Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Application No.: 10/045360   Filing Date: 22/Jan/2002

Abstract:

The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the mRNA levels of a gene that responds to the drug, such as a steroid, to the mRNA levels of a gene that does not respond to the drug. Methods according to the invention are useful for predicting the ability of a patient (or a tissue, body fluid or cell sample in vitro) to respond to a drug or steroid at any stage of their treatment (i.e., before, during or after), and to monitor the patient (or a tissue, body fluid or cell) over time to assess continued responsiveness to the drug or steroid.

Priority:

Inventor: WHITEHEAD ALEXANDER STEVEN [US]


Patent No.: US6884424B2  Issued: 26/Apr/2005

Title: Method for treating the pathological lesions of the skin that develop by ultraviolet radiation of the sunlight

Applicant/Assignee: N-GENE RESEARCH LABORATORIES INC

Application No.: 10/005074   Filing Date: 07/Dec/2001

Abstract:

The invention relates to methods for prevention and/or treatment of skin lesions caused by exposure to ultraviolet radiation. Exemplary condition that can be prevented or treated are actinic keratosis, dry skin, polymorphic light exanthema, photopathology, photo-allergy, solar atrophy, stria migrans, elastoma diffusum, X-ray dermatitis, gouty polychondritis and decubitis ulcer. The method employs application to the skin of a composition comprising a hydroximic acid derivative of the formula

Priority: HU19950003728 Applic. Date: 1995-12-22; US1998-205281 Applic. Date: 1998-12-04; US1996-771410 Applic. Date: 1996-12-20

Inventor: FARKAS BEA [HU]; NAGY PETER LITERATI [HU]; VADASZ AGNES [HU]; VIGH LASZLO [HU]


Patent No.: US6884434B1  Issued: 26/Apr/2005

Title: Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof

Applicant/Assignee: ADERIS PHARMACEUTICALS, INC

Application No.: 09/647290   Filing Date: 28/Nov/2000

Abstract:

A transdermal therapeutic system, comprising a backing layer inert to the components of the matrix, a self-adhesive matrix layer containing (-)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol in an effective amount and a protective foil or sheet to be removed prior to use, is characterised by a matrix that is based on a non-aqueous, acrylate-based or silicone-based polymer adhesive system having a solubility of >=5% (w/w) for (-)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]-amino]-1-naphthalenol, and said matrix is substantially free of inorganic silicate particulates.

Priority: DE19981014084 Applic. Date: 1998-03-30; WO1999EP01795 Applic. Date: 1999-03-18

Inventor: MULLER WALTER [DE]; PECK JAMES V [US]


Patent No.: US6887260B1  Issued: 03/May/2005

Title: Method and apparatus for acne treatment

Applicant/Assignee: LIGHT BIOSCIENCE, LLC

Application No.: 09/933870   Filing Date: 22/Aug/2001

Abstract:

Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the treatment of acne and acne scarring by treating sebaceous oil glands and the surrounding tissue with an exogenous chromophore composition and then exposing the target tissue to visible, infrared, or ultraviolet light to inhibit the activity of the oil gland and eliminate acne bacteria. The treatment method of the present invention may be futher augmented by enhancing the penetration of the topical composition into the oil gland and surrounding tissue through the use of procedures including enzyme peeling, microderm abrasion, or ultrasound.

Priority: US2001-819082 Applic. Date: 2001-02-15; US1998-203178 Applic. Date: 1998-11-30

Inventor: MCDANIEL DAVID H [US]


Patent No.: US6887400B1  Issued: 03/May/2005

Title: WATER-SOLUBLE POLYAMINOAMIDES COMPRISING 1,3-DIIMINES AS SUNSCREEN AGENTS

Applicant/Assignee: NALCO COMPANY

Application No.: 10/696835   Filing Date: 30/Oct/2003

Abstract:

A UV-protective composition comprising a water-soluble polyaminoamide containing 1,3-diimine groups, wherein the polyaminoamide containing 1,3-diimine groups absorbs ultraviolet light radiation having a wavelength of about 200 nm to about 420 nm, and methods of treating substrates with the UV-protective polyaminoamide containing 1,3-diimine groups.

Priority:

Inventor: WEI MINGLI [US]; HESSEFORT YIN Z [US]; CARLSON WAYNE M [US]


Patent No.: US6887830B2  Issued: 03/May/2005

Title: Surfactant adjuvants useful in herbicide compositions

Applicant/Assignee: HUNTSMAN PETROCHEMICAL CORPORATION

Application No.: 10/175535   Filing Date: 18/Jun/2002

Abstract:

Surfactant adjuvants that improve the bioefficacy of herbicides by combining known surfactancy, or wetting characteristics, of sulfosuccinate or sulfosuccinamate-based surfactants, with the proven bioefficiacy characteristics of alkoxylated amine-based surfactants. The surfactant adjuvants contain an amine-based surfactant, and a sulfosuccinate or sulfosuccinamate-based surfactant. The surfactant adjuvants are combined with herbicidal active ingredients, and optionally, one or more formulation aids to form herbicide compositions that have a reduced tendency to cause eye and skin irritation and can be used to control unwanted weeds or vegetation.

Priority: US19990166933P Applic. Date: 1999-11-22; US2000-718208 Applic. Date: 2000-11-21

Inventor: STRIDDE HOWARD MEYER [US]; ASHRAWI SAMIR S [US]; LEWIS DAVID CHARLES [US]; ELSIK CURTIS MICHAEL [US]; KIRBY ANDREW FRANCIS [AU]


Patent No.: US6894012B2  Issued: 17/May/2005

Title: Foaming composition based on silica and on cationic polymer

Applicant/Assignee: L'OREAL

Application No.: 10/199177   Filing Date: 22/Jul/2002

Abstract:

The present application relates to a cleansing composition comprising, in a physiologically acceptable aqueous medium, (1) at least one foaming surfactant, (2) at least 1% by weight of at least one silica with respect to the total weight of the composition, (3) at least one oxyalkylated compound and (4) at least one polymer chosen from cationic polymers and amphoteric polymers. The composition obtained has the consistency of a gel and gives a lather of very good quality. It can be used in particular in the cosmetic or dermatological field, as products for cleansing or removing make-up from the skin, eyes, scalp and/or hair, and/or to disinfect the skin and/or the scalp.

Priority: FR20010009767 Applic. Date: 2001-07-20

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]; BORDEAUX DOMINIQUE [FR]


Patent No.: US6894034B1  Issued: 17/May/2005

Title: Sebum production inhibitors

Applicant/Assignee: MARUHA CORPORATION

Application No.: 10/089179   Filing Date: 27/Mar/2002

Abstract:

Sebum production inhibitors containing as an active ingredient a compound of general formula (1) below having a glucuronic acid derivative and a glucosamine derivative in the structure or a pharmacologically acceptable salt thereof

Priority: JP19990272022 Applic. Date: 1999-09-27; WO2000JP06638 Applic. Date: 2000-09-27

Inventor: YATSUKA NOBUAKI [JP]; SATO NOBUYUKI [JP]; NISHIKAWA MASAZUMI [JP]; TAMAI TADAKAZU [JP]; MORIYAMA SHIGERU [JP]


Patent No.: US6895280B2  Issued: 17/May/2005

Title: Rechargeable spinal cord stimulator system

Applicant/Assignee: ADVANCED BIONICS CORPORATION

Application No.: 10/307098   Filing Date: 27/Nov/2002

Abstract:

A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery.

Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.

Priority: US19990145829P Applic. Date: 1999-07-27; US2000-626010 Applic. Date: 2000-07-26

Inventor: MEADOWS PAUL M [US]; WOODS CARLA MANN [US]; PETERSON DAVID K [US]; CHEN JOEY [US]; PAYNE DAVID H [US]


Patent No.: US6896889B2  Issued: 24/May/2005

Title: Immediate effect anti-wrinkle composition, based on an aqueous dispersion, of at least one mineral filler

Applicant/Assignee: L'OREAL

Application No.: 10/116049   Filing Date: 05/Apr/2002

Abstract:

The invention relates to a cosmetic composition having an immediate anti-wrinkle effect, containing an effective amount of at least one mineral filler, with the exclusion of any mixed silicate, the mineral filler being in the form of colloid particles in a stable dispersion in an aqueous medium. The invention also relates to using such a filler as a tensing agent in and/or for preparing a cosmetic composition.

Priority: FR20010004743 Applic. Date: 2001-04-06

Inventor: CHEVALIER VERONIQUE [FR]; ROGER VERONIQUE [FR]; CASSIN GUILLAUME [FR]


Patent No.: US6897203B2  Issued: 24/May/2005

Title: Polysaccharidic esters of retinoic acid

Applicant/Assignee: EURAND PHARMACEUTICALS LTD

Application No.: 10/483638   Filing Date: 14/Jan/2004

Abstract:

The present invention relates to polysaccharidic esters of retinoic acid, wherein the hydroxyl groups of the monosaccharidic units of the polysaccharide are partially or totally esterified with retinoic acid. A process to obtain these esters is also described. The products according to the present invention can be used in the pharmaceutical and cosmetic field.

Priority: WO2002EP07895 Applic. Date: 2002-07-16; IT2001TS00017 Applic. Date: 2001-07-17

Inventor: RASTRELLI ALESSANDRO [IT]; MIGLIERINI GIULIANA [IT]; PERBELLINI ALBERTO [IT]; STUCCHI LUCA [IT]


Patent No.: US6897236B1  Issued: 24/May/2005

Title: Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha

Applicant/Assignee: LEO PHARMACEUTICAL PRODUCTS, LTD

Application No.: 10/030941   Filing Date: 22/Feb/2002

Abstract:

The present invention relates to compounds of formula (I) wherein R1, R2 and R3 independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, carbamoyl, or phenyl

R1 and R2 further represented by nitro and R3 by carboxy

R4 represents hydrogen, (C1-C3)alkyl, or allyl

Q represents a bond, or -C(R6)(R7)(-O-C-O)-, in which formula R6 and R7 independently represent hydrogen, trifluoromethyl, or (C1-C4)alkyl

Y represents either (C5-C15)alkyl, (C2-C15)olefinic group, (C3-C10)monocyclic hydrocarbon, or phenyl, any of which may be optionally substituted with one or more, same or different substituents represented by the formula R5

or (C1-C4)alkyl substituted with at least one or more substituents with the formula R5

or Y represents a group of formula -CH2-(Z-O)n-Z where Z is a (C1-C3)alkyl, where n is a integer>1 and no continuous linear sequence of atoms in the group Y>15

R5 represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, -COOH, -CONH2, -CONHR', or -COONR'R' wherein R' stands for (C1-C3)alkyl

X represents oxygen or sulphur, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.

Priority: WO2000DK00386 Applic. Date: 2000-07-11; US19990144063P Applic. Date: 1999-07-16

Inventor: OTTOSEN ERIK RYTTER [DK]; DANNACHER HEINZ WILHELM [DK]


Patent No.: US6897281B2  Issued: 24/May/2005

Title: Breathable polyurethanes, blends, and articles

Applicant/Assignee: NOVEON IP HOLDINGS CORP

Application No.: 10/174899   Filing Date: 19/Jun/2002

Abstract:

A breathable polyurethane having an upright moisture vapor transmission rate (MVTR) of more than about 500 gms/m<2>/24 hr comprises: (a) poly(alkylene oxide) side-chain units in an amount comprising about 12 wt. % to about 80 wt. % of said polyurethane, wherein (i) alkylene oxide groups in said poly(alkylene oxide) side-chain units have from 2 to 10 carbon atoms and are unsubstituted, substituted, or both unsubstituted and substituted, (ii) at least about 50 wt. % of said alkylene oxide groups are ethylene oxide, and (iii) said amount of said side-chain units is (i) at least about 30 wt. % when the molecular weight of said side-chain units is less than about 600 grams/mole, (ii) at least about 15 wt. % when the molecular weight of said side-chain units is from about 600 to about 1,000 grams/mole, and at least about 12 wt.

% when the molecular weight of said side-chain units is more than about 1,000 grams/mole, and (b) poly(ethylene oxide) main-chain units in an amount comprising less than about 25 wt. % of said polyurethane. Coatings and films for textiles and other articles and applications using such polyurethanes have excellent breathability, i.e., high moisture vapor transmission rates (MVTR).

Priority: US20020370135P Applic. Date: 2002-04-05

Inventor: LUBNIN ALEXANDER V [US]; SNOW GEORGE E [US]; VARN RONALD D [US]; ANDERLE GARY A [US]


Patent No.: US6899894B1  Issued: 31/May/2005

Title: Transdermal therapeutic system containing hormones and crystallization inhibitors

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 09/720287   Filing Date: 10/May/2001

Abstract:

A transdermal therapeutic system in plaster form for controlled release of oestradiol in combination with norethisterone acetate, comprising a backing layer, a reservoir supersaturated with active ingredients which is attached to said backing layer and prepared using polyacrylate pressure-sensitive adhesives and crystallization inhibitors, and a detachable protective layer, is characterized in that the crystallization inhibitor is an amino-containing polymer.

Priority: DE19981028273 Applic. Date: 1998-06-25; WO1999EP03922 Applic. Date: 1999-06-08

Inventor: KLEIN ROBERT [DE]; MECONI REINHOLD [DE]; MUELLER WALTER [DE]


Patent No.: US6899897B2  Issued: 31/May/2005

Title: Gum resin as a carrier for topical application of pharmacologically active agents

Applicant/Assignee: JALEVA, INC

Application No.: 10/053313   Filing Date: 18/Jan/2002

Abstract:

The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.

Priority: US20010299377P Applic. Date: 2001-06-18

Inventor: BATTAGLIA ALEX [US]


Patent No.: US6899901B2  Issued: 31/May/2005

Title: Sensate composition imparting initial sensation upon contact

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION TAKASAGO INTERNATIONAL CORPORATION (USA)

Application No.: 10/464149   Filing Date: 17/Jun/2003

Abstract:

The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.

Priority: US2000-498592 Applic. Date: 2000-02-04

Inventor: NAKATSU TETSUO [US]; MAZEIKO PETER J [US]; LUPO JR ANDREW T [US]; GREEN CARTER B [US]; MANLEY CHARLES H [US]; SPENCE DAVID J [US]; OHTA HIDEAKI [JP]


Patent No.: US6902338B2  Issued: 07/Jun/2005

Title: Customized personal cleansing article

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC

Application No.: 10/328919   Filing Date: 26/Dec/2002

Abstract:

A customized cleansing article provides the user with an assortment of one or more of skin cleansing, aesthetic, and skin benefit bars contained within a porous pouch. The toilet bars are characterized by a rigidity index greater than 0.2 Mpa at 25 C.

Priority:

Inventor: PUVVADA SUDHAKAR [US]; MORIKIS THOMAS [US]


Patent No.: US6902722B2  Issued: 07/Jun/2005

Title: Aqueous antisun/sunscreen compositions comprising amphiphilic 2-Acrylamidomethylpropanesulfonic acid polymers and water-soluble silicones

Applicant/Assignee: L'OREAL

Application No.: 10/823669   Filing Date: 14/Apr/2004

Abstract:

Photoprotective compositions well suited for the photoprotection of the skin, lips and/or hair against the damaging effect of UV-radiation comprise at least one aqueous phase and at least one system for screening out UV-radiation, and which also contain: (a) at least one partially or totally neutralized, crosslinked or non-crosslinked amphiphilic polymer of 2-acrylamidomethylpropanesulfonic acid (AMPS), and (b) at least one water-soluble silicone comprising at least one terminal or pendent monovalent polyoxyalkylene group.

Priority: FR20030004650 Applic. Date: 2003-04-14; US20030468053P Applic. Date: 2003-05-06

Inventor: CANDAU DIDIER [FR]; BOUTELET KARL [FR]; SEYLER NATHALIE [FR]


Patent No.: US6902737B2  Issued: 07/Jun/2005

Title: Translucent nanoemulsion, production method, and uses thereof in the cosmetic, dermatological and/or ophthalmological fields

Applicant/Assignee: L'OREAL

Application No.: 10/182401   Filing Date: 30/Jul/2002

Abstract:

The nanoemulsion according to the invention comprises an oily phase dispersed in an aqueous phase, having oil globules with a number-average size less than 100 nm, characterized in that it contains a ternary surfactant system comprising: a) a mixture of at least two nonionic surfactants comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least one fatty acid ester of sorbitan

and b) at least one ionic surfactant chosen from alkali metal salts of cetyl phosphate and alkali metal salts of palmitoyl sarcosinate. Use in the manufacture of cosmetic, dermatological and ophthalmological compositions.

Priority: FR20010000696 Applic. Date: 2001-01-18; WO2002FR00130 Applic. Date: 2002-01-14

Inventor: QUEMIN ERIC [FR]


Patent No.: US6902743B1  Issued: 07/Jun/2005

Title: Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Application No.: 09/055505   Filing Date: 06/Apr/1998

Abstract:

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.

Priority: US1997-920326 Applic. Date: 1997-08-21; US1997-088961 Applic. Date: 1997-07-17; US1997-788734 Applic. Date: 1997-01-23; US1996-086988 Applic. Date: 1996-08-16; US1996-675895 Applic. Date: 1996-07-05; US1996-598874 Applic. Date: 1996-02-09; US1996-590973 Applic. Date: 1996-01-24; US1995-446149 Applic. Date: 1995-05-22; US1995-446148 Applic. Date: 1995-05-22

Inventor: SETTERSTROM JEAN A [US]; TICE THOMAS R [US]; JACOB ELLIOT [US]; REID ROBERT H [US]; VAN HAMONT JOHN [US]; BOEDECKER EDGAR C [US]; JEYANTHI RAMASSUBBU [US]; FRIDEN PHIL [US]; ROBERTS F DONALD [US]; MCQUEEN CHARLES E [US]; BHATTACHARJEE APURBA [US]; CROSS ALAN [US]; SADOFF JERALD [US]; ZOLLINGER WENDELL [US]


Patent No.: US6903196B1  Issued: 07/Jun/2005

Title: Methods for identifying and isolating tissue-specific lumen-exposed molecules

Applicant/Assignee: UTAH VENTURES II, L.P

Application No.: 09/528742   Filing Date: 20/Mar/2000

Abstract:

This invention provides novel methods of and kits for labeling and isolating lumen-exposed molecules, particularly polypeptides which are expressed in a tissue-specific or organ-specific manner. The methods and kits can be used to isolate molecules exposed on the luminal side of cells lining vascular, ductal, sinus, respiratory, fascial, and other perfusible tissue spaces.

Priority: US19990139579P Applic. Date: 1999-06-17

Inventor: ROBEN PAUL [US]; STEVENS ANTHONY C [US]


Patent No.: US6905193B2  Issued: 14/Jun/2005

Title: Method and apparatus for printing grey levels with curable inks

Applicant/Assignee: AGFA GEVAERT

Application No.: 10/393314   Filing Date: 20/Mar/2003

Abstract:

A method and apparatus for dot matrix printing of an image on a printing medium using radiation curable compositions is described. The image is printed using the radiation curable composition as at least one set of mutually interstitially printed sub-images, each sub-image comprising a set of dots, a dot consisting of a number of droplets applied on top of each other, each droplet being formed from one of a plurality of radiation curable compositions, the droplets mixing on the printing medium thus forming the dot with a specific grey level. Before printing a next sub-image from the set of sub-images, the dots of the previously interstitially printed sub-image are actively rendering non-migratory by exposing them to radiation.

Priority: EP20020100329 Applic. Date: 2002-04-02; US20020371547P Applic. Date: 2002-04-10

Inventor: VANHOOYDONCK RUDI [BE]


Patent No.: US6905674B2  Issued: 14/Jun/2005

Title: Aqueous photoprotective compositions comprising acrylamido-2-methylpropanesulfonic acid polymers and 4,4-diarylbutadiene UV-A sunscreens

Applicant/Assignee: L'OREAL

Application No.: 10/823670   Filing Date: 14/Apr/2004

Abstract:

Photoprotective compositions, e.g., oil-in-water or water-in-oil emulsions, well suited for the photoprotection of the skin, lips and/or hair against the damaging effects of UV-radiation, comprise at least one aqueous phase, at least one oily phase, at least one partially or completely neutralized, crosslinked or non-crosslinked water-soluble or water-dispersible acrylamido-2-methylpropanesulfonic acid (AMPS) polymer and at least one UV radiation-screening system, said at least one screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent

Priority: US20030468089P Applic. Date: 2003-05-06; FR20030004647 Applic. Date: 2003-04-14

Inventor: L ALLORET FLORENCE [FR]


Patent No.: US6905694B1  Issued: 14/Jun/2005

Title: Hydrophobically modified polysaccharide in personal care products

Applicant/Assignee: HERCULES INCORPORATED

Application No.: 08/855779   Filing Date: 12/May/1997

Abstract:

A personal care composition is composed of: (a) from about 0.1% to about 99% by weight of a vehicle system which comprises a hydrophobically modified nonionic water soluble polysaccharide polymer which comprises a water soluble polysaccharide polymer backbone and a hydrophobic moiety selected from the group consisting of 3-alkoxy-2-hydroxypropyl group wherein the allyl moiety is a straight or branch chain having 2-6 carbon atoms, C3-C7 alky aryl alkyl, alkyl aryl groups and mixtures thereof, wherein the ratio of the hydrophilic portion to the hydrophobic portion of the polymer is from about 2:1 to 1000:1, and (b) at least one other personal care ingredient. This compostion can be used in a wide range of personal care products such as shampoos, conditioners, hair coloring and styling agents, soaps, body washing agents, underarm products, lubricating agents, oral care products, denture adhesives, sunscreen agents, make-up products, and the like.

Priority:

Inventor: MODI JASHAWANT J [US]


Patent No.: US6905695B1  Issued: 14/Jun/2005

Title: Solid composition and its uses, in particular its cosmetic uses

Applicant/Assignee: L'OREAL

Application No.: 09/610320   Filing Date: 05/Jul/2000

Abstract:

The invention relates to a solid composition in the form of a water-in-oil emulsion. The aqueous phase represents at least 70% by weight with respect to the total weight of the composition. The composition contains at least one silicone emulsifier and at least 3% by weight of at least one wax with respect to the total weight of the composition.

Priority: FR19990009013 Applic. Date: 1999-07-12

Inventor: AFRIAT ISABELLE [FR]; BOULIER VIRGINIE [FR]


Patent No.: US6905738B2  Issued: 14/Jun/2005

Title: Generation of viable cell active biomaterial patterns by laser transfer

Applicant/Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

Application No.: 10/068315   Filing Date: 08/Feb/2002

Abstract:

A method for depositing a transfer material onto a receiving substrate uses a source of laser energy, a receiving substrate, and a target substrate. The target substrate comprises a laser-transparent support having a laser-facing surface and a support surface. The target substrate also comprises a composite material having a back surface in contact with the support surface and a front surface. The composite material comprises a mixture of the transfer material to be deposited and a matrix material. The matrix material is a material that has the property that, when it is exposed to laser energy, it desorbs from the laser-transparent support.

The source of laser energy is positioned in relation to the target substrate so that laser energy is directed through the laser-facing surface of the target substrate and through the laser-transparent support to strike the composite material at a defined target location. The receiving substrate is positioned in a spaced relation to the target substrate. The source of laser energy has sufficient energy to desorb the composite material at the defined target location, causing the composite material to desorb from the defined target location and be lifted from the support surface of the laser-transparent support. The composite material is deposited at a defined receiving location on the receiving substrate. The method is useful for creating a pattern of biomaterial on the receiving substrate.

Priority: US2000-671166 Applic. Date: 2000-09-28; US1999-318134 Applic. Date: 1999-05-25; US19990117468P Applic. Date: 1999-01-27; US20010269384P Applic. Date: 2001-02-20

Inventor: RINGEISEN BRADLEY R [US]; CHRISEY DOUGLAS B [US]; PIQUE ALBERTO [US]; MCGILL R ANDREW [US]


Patent No.: US6906026B1  Issued: 14/Jun/2005

Title: Methods for treating conditions associated with the accumulation of excess extracellular matrix

Applicant/Assignee: THE UNIVERSITY OF RESEARCH FOUNDATION

Application No.: 09/869820   Filing Date: 05/Jul/2001

Abstract:

The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFbeta, or using agents that inhibit TGFbeta in combination with agents that degrade excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.

Priority: US19990114795P Applic. Date: 1999-01-05; WO2000US00179 Applic. Date: 2000-01-05

Inventor: NOBLE NANCY A [US]; BORDER WAYNE A [US]


Patent No.: US6906106B2  Issued: 14/Jun/2005

Title: Compositions for the skin comprising fibers and ubiquinones and methods of using the same

Applicant/Assignee: L'OREAL

Application No.: 10/102632   Filing Date: 22/Mar/2002

Abstract:

The present invention relates to a composition for topical application on the skin, comprising fibers and at least one or two or more compounds selected from the group of the ubiquinones and derivatives thereof. The ubiquinone can in particular be coenzyme Q10. The composition of the invention makes it possible to improve the appearance of the skin, immediately as well as in the longer term, and to mask the imperfections and/or signs of ageing of the skin while maintaining a natural appearance of the skin.

Priority: FR20010003960 Applic. Date: 2001-03-23

Inventor: CHEVALIER VERONIQUE [FR]


Patent No.: US6908608B1  Issued: 21/Jun/2005

Title: Stabilization of body-care and household products

Applicant/Assignee: CIBA SPECIALTY CHEMICAL CORPORATION

Application No.: 09/830788   Filing Date: 25/Jul/2001

Abstract:

A description is given of the use of light stabilizers of formulae (1) and/or (2) for protecting body-care and household products from photolytic degradation.

Priority: WO1999EP07980 Applic. Date: 1999-10-21; US19980106633P Applic. Date: 1998-11-02

Inventor: HUEGLIN DIETMAR [DE]; EHLIS THOMAS [DE]; KRAMER ERICH [CH]; LUPIA JOSEPH ANTHONY [US]; REICH OLIVER [DE]


Patent No.: US6908760B2  Issued: 21/Jun/2005

Title: Raised surface assay plate

Applicant/Assignee: TRANSFORM PHARMACEUTICALS, INC

Application No.: 10/439943   Filing Date: 16/May/2003

Abstract:

The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

Priority: US20020428164P Applic. Date: 2002-11-21; US2002-282505 Applic. Date: 2002-10-28

Inventor: CIMA MICHAEL [US]; LEWIS WENDY PRYCE [US]; GONZALEZ-ZUGASTI JAVIER [US]; GYORY J RICHARD [US]; LEMMO ANTHONY V [US]; MONAGLE JULIE [US]


Patent No.: US6908925B2  Issued: 21/Jun/2005

Title: Treating skin wrinkles/fine lines with calcium channel inhibitors

Applicant/Assignee: L'OREAL

Application No.: 09/981751   Filing Date: 19/Oct/2001

Abstract:

A regime or regimen for loosening/slackening and/or relaxing cutaneous and/or subcutaneous human skin tissue, advantageously for cosmetically/therapeutically treating skin wrinkles and fine lines, comprises administering to a candidate subject in need of such treatment, a thus-effective amount of at least one inhibitor of at least one calcium channel.

Priority: FR19990006290 Applic. Date: 1999-05-18; US2000-572234 Applic. Date: 2000-05-17

Inventor: BRETON LIONEL [FR]; NONOTTE ISABELLE [FR]


Patent No.: US6911436B2  Issued: 28/Jun/2005

Title: Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same

Applicant/Assignee: DERMAL RESEARCH LABORATORIES, INC DERMAL RESERACH LABORATORIES, INC

Application No.: 09/880907   Filing Date: 15/Jun/2001

Abstract:

The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.

Priority: US1999-277602 Applic. Date: 1999-03-29; US1994-241692 Applic. Date: 1994-05-12

Inventor: BROWN HAROLD G [US]; BROWN KAREN K [US]


Patent No.: US6913711B2  Issued: 05/Jul/2005

Title: Corrosion inhibitors

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 09/741490   Filing Date: 19/Dec/2000

Abstract:

There is provided a cosmetic or topical composition for use on the human body having a phosphate compound in an amount effective to inhibit corrosion of metallic containers containing the composition. Preferably, such a cosmetic or topical composition has sodium hydrogen phosphates and/or sodium polyphosphates in an amount about 0.05 wt % to about 1.5 wt % based on the total weight of the finished composition.

Priority:

Inventor: MCKIE DERRICK B [US]; ROBINSON FREDA [US]; FRANCO PHILIP [US]


Patent No.: US6914075B2  Issued: 05/Jul/2005

Title: Cystine derivative and agent for suppressing activation of inflammatory factors

Applicant/Assignee: AJINOMOTO CO., INC

Application No.: 10/632959   Filing Date: 04/Aug/2003

Abstract:

The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives

a method for suppressing the activation of inflammatory factors by administering the composition

a method for preventing, ameliorating and/or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition

a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition

and pharmaceutical agents containing the cystine derivatives.

Priority: JP20010027367 Applic. Date: 2001-02-02; WO2002JP00222 Applic. Date: 2002-01-16

Inventor: NAKANO TAKASHI [JP]; KITAZAWA MANABU [JP]; IWASAKI KEIJI [JP]; SAKAMOTO KAZUTAMI [JP]


Patent No.: US6919071B2  Issued: 19/Jul/2005

Title: Sunscreen milk

Applicant/Assignee: LABORATOIRES EXPANSCIENCE

Application No.: 10/240718   Filing Date: 20/Nov/2003

Abstract:

The invention concerns a cosmetic or dermatological composition for protection against ultraviolet radiation, based on inorganic screening agent, characterized in that it comprises a water-in-oil emulsion containing a combination of at least a particulate inorganic sunscreening agent, selected among the group consisting of titanium dioxide, zinc oxide and mixtures thereof, and at least an emulsifier selected among the group consisting of silicone derivatives with glycosidic constituent, the particulate screening agent being homogeneously dispersed in the water-in-oil emulsion.

Priority: FR20000004360 Applic. Date: 2000-04-05; WO2001FR01007 Applic. Date: 2001-04-04

Inventor: CHOULOT JEAN-CHRISTOPHE [FR]; PETIT NATHALIE [FR]; MSIKA PHILIPPE [FR]; FERRARIS PATRICIA [FR]; RIBES DELPHINE [FR]; HILAIRE JOCELYNE [FR]


Patent No.: US6920883B2  Issued: 26/Jul/2005

Title: Methods and apparatus for skin treatment

Applicant/Assignee: ARTHROCARE CORPORATION

Application No.: 10/291213   Filing Date: 08/Nov/2002

Abstract:

Methods and apparatus for electrosurgically treating human skin. The skin may be treated by applying thermal energy to the dermis to shrink the skin following liposuction, or to induce collagen deposition at the site of a wrinkle for wrinkle reduction or removal. In another embodiment, a method involves electrosurgically removing or modifying tissue in the head or neck to provide a face-lift or a neck-lift. In one embodiment, the working end of an electrosurgical instrument is positioned in at least close proximity to the dermis by approaching the dermis from the underside (reverse side) of the skin.

Priority: US20010337496P Applic. Date: 2001-11-08

Inventor: BESSETTE ANDRE P [US]; PACEK JAMES L [US]


Patent No.: US6920884B2  Issued: 26/Jul/2005

Title: Method of providing cosmetic/medical therapy

Applicant/Assignee:

Application No.: 10/307248   Filing Date: 27/Nov/2002

Abstract:

A method for providing medical therapy treatment includes steps for preparing an electrically activated substance, and for using and applying the electrically activated substance internally to a human or animal subject. The electrical activation process of the substance includes making changes in a physical property thereof, as demonstrated by the results.

Priority: US2002-211654 Applic. Date: 2002-08-02; US2001-919493 Applic. Date: 2001-07-31; US1999-289409 Applic. Date: 1999-04-09; US2002-207651 Applic. Date: 2002-07-26; US2001-032323 Applic. Date: 2001-10-24; US2000-670734 Applic. Date: 2000-09-27; US1999-259120 Applic. Date: 1999-02-26; US1997-865253 Applic. Date: 1997-05-29

Inventor: ORTON KEVIN [US]


Patent No.: US6923976B2  Issued: 02/Aug/2005

Title: Methods compositions and devices utilizing stinging cells/capsules for delivering therapeutic or a cosmetic agent into a tissue

Applicant/Assignee: NANOCYTE INC

Application No.: 10/406202   Filing Date: 04/Apr/2003

Abstract:

A composition of matter including a cosmetic agent and at least one stinging capsule and methods of use are described.

Priority: US2001-963672 Applic. Date: 2001-09-27; US20000235910P Applic. Date: 2000-09-28

Inventor: LOTAN TAMAR [IL]; ECKHOUSE SHIMON [IL]


Patent No.: US6927205B2  Issued: 09/Aug/2005

Title: Compositions and methods for treatment of psoriasis

Applicant/Assignee: PROCYTE CORPORATION

Application No.: 10/426239   Filing Date: 28/Apr/2003

Abstract:

A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.

Priority:

Inventor: PATT LEONARD M [US]


Patent No.: US6927206B2  Issued: 09/Aug/2005

Title: Compositions and methods for treatment of rosacea

Applicant/Assignee: PROCYTE CORPORATION

Application No.: 10/457045   Filing Date: 06/Jun/2003

Abstract:

A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating rosacea.

Priority:

Inventor: PATT LEONARD M [US]


Patent No.: US6929939B2  Issued: 16/Aug/2005

Title: Proteins producing an altered immunogenic response and methods of making and using the same

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/104693   Filing Date: 22/Mar/2002

Abstract:

The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.

Priority: US20010278459P Applic. Date: 2001-03-23

Inventor: ESTELL DAVID A [US]; GANSHAW GRANT C [US]; HARDING FIONA A [US]; LARENAS EDMUND A [US]; POULOSE AYROOKARAN J [US]; SIKORSKI ELIZABETH E [US]; RUSSELL ELLIOTT P [GB]


Patent No.: US6936187B2  Issued: 30/Aug/2005

Title: Functionalized cubic liquid crystalline phase materials and methods for their preparation and use

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/075551   Filing Date: 14/Feb/2002

Abstract:

Functionalized cubic gel precursors, functionalized cubic liquid crystalline gels, dispersions of functionalized cubic gel particles and functionalized cubic gel particles are disclosed. Methods for preparing and using the precursors, gels, dispersions, and particles are also disclosed. The precursors, gels, dispersions, and particles are used to deliver active ingredients to substrates.

Priority: US20010270307P Applic. Date: 2001-02-21

Inventor: LYNCH MATTHEW LAWRENCE [US]; SPICER PATRICK THOMAS [US]


Patent No.: US6936242B2  Issued: 30/Aug/2005

Title: Multi-portion antiperspirant composition

Applicant/Assignee: THE GILLETTE COMPANY

Application No.: 10/298113   Filing Date: 15/Nov/2002

Abstract:

Disclosed is a non-flowable anhydrous topical antiperspirant composition comprising a first portion and a second portion contiguous with the first portion. The first portion is semi-opaque to opaque and comprises a first hydrophobic carrier vehicle and a first gellant and has a particulate antiperspirant active suspended therein. The second portion is translucent to transparent and comprises a second hydrophobic carrier vehicle and a second gellant. Preferably, the second hydrophobic carrier vehicle has an average refractive index that approximately matches the refractive index of the second gellant. Ideally, for greater translucency the second portion will be substantially free of antiperspirant salt and/or other opacifying materials.

Preferably, the first hydrophobic carrier vehicle also has an average refractive index that approximately matches the refractive index of the first gellant. Even more preferably, the second hydrophobic carrier vehicle and second gellant are comprised of substantially the same materials in substantially the same proportions as the first hydrophobic carrier vehicle and first gellant.

Priority:

Inventor: ELLIOTT DAVID L [US]; COLWELL DENNIS J [US]; SANE JAYANT N [US]; VU TUAN M [US]; GALANTE CHERYL LYNN [US]


Patent No.: US6936266B2  Issued: 30/Aug/2005

Title: Desquamation/epidermal renewal of the skin and/or combating skin aging

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/397274   Filing Date: 27/Mar/2003

Abstract:

Cinnamic acid and derivatives thereof are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a human subject in need of such treatment, by topically applying thereto, for such period of time as required to elicit the desired response, a cosmetically/therapeutically effective amount of cinnamic acid and/or of at least one derivative thereof.

Priority: FR19980005967 Applic. Date: 1998-05-12; US1999-305213 Applic. Date: 1999-05-05

Inventor: BRETON LIONEL [FR]; LIVIERO CHRISTEL [FR]


Patent No.: US6936278B2  Issued: 30/Aug/2005

Title: Microparticles

Applicant/Assignee: JAGOTEC AG

Application No.: 10/162674   Filing Date: 06/Jun/2002

Abstract:

A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active substance, an emulsion of starch droplets is formed in an outer phase of polymer solution, the starch droplets are made to gel, the gelled starch particles are dried, and a release-controlling shell is optionally applied to the particles, wherein at least one buffer substance having the ability of keeping the pH of the produced microparticles above 3 if exposing the microparticles to an aqueous evironment is added at any stage during the process. Microparticles which essentially consist of said starch, have an amino acid content of less than 50 mug and have no covalent chemical cross-linking and which have the aktivity of keeping the pH above 3 if exposed to a aqueous environment.

Priority: SE20020000873 Applic. Date: 2002-03-21; SE20020001599 Applic. Date: 2002-05-30

Inventor: RESLOW MATS [SE]; JOENSSON MONICA [SE]; LARSSON KARIN [SE]; LAAKSO TIMO [GB]


Patent No.: US6936280B1  Issued: 30/Aug/2005

Title: Method for preparing a composition by extraction of mother-of-pearl, composition obtained by said method and use thereof in cosmetics and dermatology

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Application No.: 10/089982   Filing Date: 03/Apr/2002

Abstract:

A method for preparing a composition, comprising a) reducing mother-of-pearl into powder with grain size distribution ranging between about 1 and about 300 mum

b) placing the obtained powder in close contact with an extracting agent in the form of a hydroglycol solution of at least a collagen, of at least a proteoglycan or a mixture thereof

then c) in collecting the extraction mixture, formed by the close contact, constituting the desired composition. The composition obtainable by said method has very interesting properties relative to the skin and/or skin appendages, in particular tissue-regenerating properties, enabling for instance improved wound healing, and anti-ageing properties for preventing and/or visibly reducing effects related to skin and/or skin appendage ageing.

Priority: FR19990012409 Applic. Date: 1999-10-05; WO2000FR02766 Applic. Date: 2000-10-05

Inventor: LOPEZ EVELYNE [FR]; CHEMOUNI ALFRED EDOUARD [FR]


Patent No.: US6943197B2  Issued: 13/Sep/2005

Title: Topical administration of pharmacologically active bases in the treatment of inflammatory dermatoses

Applicant/Assignee:

Application No.: 10/176962   Filing Date: 21/Jun/2002

Abstract:

Provided are methods and topical pharmaceutical formulations for the treatment of inflammatory dermatoses. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations are particularly suited to the treatment of acne vulgaris.

Priority:

Inventor: MAIBACH HOWARD I [US]; LUO ERIC C [US]; HSU TSUNG-MIN [US]


Patent No.: US6943200B1  Issued: 13/Sep/2005

Title: Water unstable foam compositions

Applicant/Assignee: PROCTER & GAMBLE COMPANY

Application No.: 10/089356   Filing Date: 27/Mar/2002

Abstract:

The present invention relates to foam components comprising polymeric material and an active ingredient, such as detergent ingredients, which are to be delivered to aqueous environment. Highly preferred active ingredients include enzymes. The foam component is stable upon contact with air but dissolves, disintegrates or disperses in water. The invention also relates to compositions containing the foam components and methods for making the foam components.

Priority: GB19990023344 Applic. Date: 1999-10-05; WO2000US27340 Applic. Date: 2000-10-04

Inventor: CORRAND DIDIER MARCEL [FR]; YORK DAVID WILLIAM [GB]; SOMERVILLE-ROBERTS NIGEL [GB]


Patent No.: US6944491B2  Issued: 13/Sep/2005

Title: Method of acquiring an image of a non-dermatoglyphic zone of the skin or of a zone of the hair by means of acquisition apparatus including a non-optical sensor

Applicant/Assignee: L'OREAL

Application No.: 09/909926   Filing Date: 20/Jul/2001

Abstract:

The invention relates to a method of acquiring an image of a non-dermatoglyphic zone of the skin or the hair by means of acquisition apparatus comprising a non-optical sensor.

Priority: FR20000010144 Applic. Date: 2000-08-01

Inventor: LEVEQUE JEAN-LUC [FR]


Patent No.: US6945402B1  Issued: 20/Sep/2005

Title: Sachet and absorbent item in a flexible-walled container

Applicant/Assignee: L'OREAL S.A

Application No.: 09/720659   Filing Date: 02/Mar/2001

Abstract:

A unit for packaging at least one absorbent structure intended to be impregnated with a liquid composition includes at least one component, packaged separately from the absorbent structure. The unit includes a flexible-walled container containing the absorbent structure, and at least one sachet containing the component. The sachet is capable of opening in response to pressure exerted on the sachet via at least one flexible wall of the container so as to cause the absorbent structure to become impregnated with the liquid composition containing the component, the sachet and the absorbent structure being free inside the container. The unit may be used for treatment, particularly cosmetic treatment, of the human skin and its superficial body growths.

Priority: WO2000FR01200 Applic. Date: 2000-05-04; FR19990005648 Applic. Date: 1999-05-04

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6945723B1  Issued: 20/Sep/2005

Title: Packaging and application device

Applicant/Assignee: L'OREAL

Application No.: 09/666450   Filing Date: 21/Sep/2000

Abstract:

Packaging and application device comprising a container having an internal space ( 12 ) in which the product (P) is contained, an application element ( 16 ), a housing ( 14 ) for housing the application element and a permeable wall ( 23 ) placed between the said housing and the internal space containing the product. The application element and the housing are both designed in such a way that the application element has, when it is in the said housing, at least one surface portion ( 16 a) located, without any appreciable axial compression, opposite an opening ( 25 ) in the permeable wall. The internal space is a variable-volume space, compression means being provided for making the said internal volume pass selectively from a first volume, greater than the volume of product, to a second volume, smaller than the first, this reduction in volume being accompanied by an overpressure which is conducive to transferring product through the said permeable wall towards the application element.

Priority:

Inventor: GUERET JEAN-LOUIS [FR]


Patent No.: US6946124B2  Issued: 20/Sep/2005

Title: Iridescent cosmetic composition and use thereof

Applicant/Assignee: L'OREAL

Application No.: 10/182704   Filing Date: 07/Aug/2002

Abstract:

The subject of the present invention is an iridescent composition for topical application, comprising at least one water-soluble surfactant and an aqueous dispersion of particles of polymer, the said particles having a mean size in numerical terms ranging from about 50 to 300 nm. The quantity of particles of polymer being at least 3% by weight of active material relative to the total weight of the composition. The composition according to the invention has a very attractive visual appearance by virtue of its iridescent color. The invention also relates to the uses of the composition of the invention in the cosmetic field, in particularly for the treatment, protection, care, removal of make-up from and/or cleansing of the skin, the lips and/or the hair, and/or for the application of make-up to the skin and/or the lips.

Priority: FR20010000682 Applic. Date: 2001-01-18; WO2002FR00128 Applic. Date: 2002-01-14

Inventor: ARNAUD-SEBILLOTTE LAURENCE [FR]; GUILLOU VERONIQUE [FR]


Patent No.: US6946490B2  Issued: 20/Sep/2005

Title: Antimicrobial treatment for herpes simplex virus and other infectious diseases

Applicant/Assignee:

Application No.: 10/093093   Filing Date: 07/Mar/2002

Abstract:

An improved medical treatment and medicine is provided to quickly and safely resolve herpes and other microbial infections. The inexpensive user-friendly medicine can be applied and maintained on the infected region until the physical symptoms of the disease disappears and the patient is comfortable and has a normal appearance. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent. In the preferred form, the medicine comprises Echinacea phytochemicals and benzalkonium chloride in a sterile water solution.

Priority: US1996-646988 Applic. Date: 1996-05-08; US1996-600217 Applic. Date: 1996-02-12

Inventor: SQUIRES MERYL [US]


Patent No.: US6946833B1  Issued: 20/Sep/2005

Title: Polar coordinates sensor having an improved flux suspension system and excitation method

Applicant/Assignee:

Application No.: 10/349526   Filing Date: 22/Jan/2003

Abstract:

An improved polar coordinates sensor comprising a pot-core half having a concentric winding window surrounded by a washer-like high conductive Lenz lens. A toroidal core stack concentrically disposed at the base end of the pot-core half, the pot-core half, Lenz lens and the toroidal core stack being disposed coaxially with aligned winding windows. X-y coordinates excitation winding distributions being shuttled through the coaxial aligned windows to encircle the cross-section of pot-core half, Lenz lens and toroidal core stack forming a series circuit. X-y excitation currents being connected to the excitation distributions to induce a hemispherical driving field. The inductive reactance of the series coupled toroidal core stack allows an increased degree of differential redistribution of driving flux in response to probe tilt. A rotating/non-rotating excitation method, of which a source of the x-y signals may include electromechanical resolver type waveforms. The sensor is further expanded by adding an outer radii auxiliary driving assembly comprising a toroid core encased by a second Lenz lens series coupled to a larger diameter toroid inductive reactance, providing the capability of two independent rotating/non-rotation concentric interacting driving fields. Further disclosed is a polar coordinates sensor having an air-core pick-up coil. Further disclosed is a "hidden metal edge mapper" for aircraft construction utilizing a tilted polar sensor indicating target by signal phase angle.

Priority: US2001-873838 Applic. Date: 2001-06-04

Inventor: LOGUE DELMAR LEON [US]; LOGUE STEPHEN JOHN [US]


Patent No.: US6949625B2  Issued: 27/Sep/2005

Title: Injectable implant of insoluble globin

Applicant/Assignee: KHORIONYX

Application No.: 10/842462   Filing Date: 11/May/2004

Abstract:

A preparation is provided which can be injected or implanted into the human or animal body, and which comprises, as main component, globin that is insoluble at physiological pH, biocompatible and sterile.

Priority: FR20030005700 Applic. Date: 2003-05-12; US20030472467P Applic. Date: 2003-05-22

Inventor: TAYOT JEAN-LOUIS [FR]


Patent No.: US6949680B2  Issued: 27/Sep/2005

Title: Ketones as precursors of active compounds

Applicant/Assignee: FIRMENICH SA

Application No.: 10/270224   Filing Date: 15/Oct/2002

Abstract:

A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an alkoxy group, R4 represents a hydrogen atom, an alkyl group, or a CF3 group, R5 represents a hydrogen atom, an alkyl group, a CF3 group or an alkoxy group, and R1 and R2 are the substituents of a terminal alkene of formula wherein R1 represents an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous or sulfur

R2 represents a hydrogen atom, an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous and sulfur.

This compound is capable of releasing, upon an exposure to light, an active compound such as a perfume and can be advantageously used in the treatment of any surface in order to perfume it through the controlled release of a perfumed molecule.

Priority: WO2000IB00804 Applic. Date: 2000-06-15; WO2001IB01021 Applic. Date: 2001-06-11

Inventor: HERRMANN ANDREAS [CH]


Patent No.: US6951888B2  Issued: 04/Oct/2005

Title: Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions

Applicant/Assignee: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG

Application No.: 10/666068   Filing Date: 19/Sep/2003

Abstract:

A compound of formula 1 wherein: R<1 >is C1-C4-alkyl

R<2 >is C1-C4-alkyl

and R<3 >is C1-C4-alkyl or phenyl, each optionally mono- or polysubstituted, or R<2 >and R<3 >together are -CH2-CH2- or -CH2-CH2-CH2-, or the corresponding acid addition salt with a pharmacologically acceptable acid, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and their use in the treatment of inflammatory and obstructive respiratory diseases.

Priority: DE20021046374 Applic. Date: 2002-10-04; US20020432499P Applic. Date: 2002-12-11

Inventor: BUETTNER FRANK [DE]; KONETZKI INGO [DE]; SCHROMM KURT [DE]; SCHOLLENBERGER HERMANN [DE]; PESTEL SABINE [DE]; SCHNAPP ANDREAS [DE]; BOUYSSOU THIERRY [DE]; HEINE CLAUDIA [DE]


Patent No.: US6955803B2  Issued: 18/Oct/2005

Title: Photoprotective compositions comprising sulfonic/hydrophobic amphiphilic polymers

Applicant/Assignee: SOCIETE L'OREAL, S.A L'OREAL

Application No.: 10/616947   Filing Date: 11/Jul/2003

Abstract:

Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of human skin and/or hair, comprise (a) at least one organic UV-screening agent and (b) an SPF-improving amount of at least one amphiphilic polymerizate of at least one ethylenically unsaturated monomer which comprises a sulfonic group, whether in the free acid or in partially or totally neutralized state, and which amphiphilic polymerizate also comprises at least one hydrophobic moiety.

Priority: FR20010000334 Applic. Date: 2001-01-11; WO2002FR00030 Applic. Date: 2002-01-04

Inventor: BOUTELET KARL [FR]; CANDAU DIDIER [FR]


Patent No.: US6956059B2  Issued: 18/Oct/2005

Title: Anti-inflammatory and immunomodulatory amino acid derivatives, their preparation and use

Applicant/Assignee: CRODA INTERNATIONAL, PLC

Application No.: 10/478819   Filing Date: 28/Jun/2004

Abstract:

The present invention ralates to compounds of formula (I): wherein R is hydrogen (H) or C1-6 alkyl

and X is defined such that -NH-(X)-COOH is the residue of an amino acid, which amino acid may itself optionally be substituted at any pendant amino group thereof by a residue of a carboxylic acid or a derivative thereof

or a salt thereof. The use of these compounds, in particular as potential anti-inflammatory and immunomodulatory drugs, and their preparation are described

Priority: GB20010012324 Applic. Date: 2001-05-21; WO2002GB02375 Applic. Date: 2002-05-20

Inventor: COUPLAND KEITH [GB]


Patent No.: US6957924B1  Issued: 25/Oct/2005

Title: Textured film devices

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER COMPANIES, INC

Application No.: 09/503262   Filing Date: 14/Feb/2000

Abstract:

A textured film device formed from at least one layer of gathered textured film. These devices are capable of producing excellent lather when used with a cleanser and are soft to the touch. Other textured film devices include mitts, gloves, washcloths, and the like formed from at least one layer of textured film. Also provided are systems comprised of the textured film devices and at least one active material selected from cleansers

moisturizers, conditioners

sunscreens

shaving foams

tanning agents

anti-acne agents

anti-aging agents

anti-irritant agents

perfumes/fragrances

and mixtures thereof.

Priority:

Inventor: MCMEEKIN LINDA [US]; DABI SHMUEL [US]


Patent No.: US6958148B1  Issued: 25/Oct/2005

Title: Linkage of agents to body tissue using microparticles and transglutaminase

Applicant/Assignee: PERICOR SCIENCE, INC

Application No.: 09/620783   Filing Date: 21/Jul/2000

Abstract:

Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.

Priority: US1999-359920 Applic. Date: 1999-07-22; US1999-234358 Applic. Date: 1999-01-20; US19980071908P Applic. Date: 1998-01-20

Inventor: GREEN HOWARD [US]; COMPTON BRUCE J [US]; COREY GEORGE D [US]; DJIAN PHILIPPE [FR]


Patent No.: US6958160B1  Issued: 25/Oct/2005

Title: Self forming, thermodynamically stable liposomes and their applications

Applicant/Assignee: BIOZONE TECHNOLOGIES, INC

Application No.: 10/262284   Filing Date: 30/Sep/2002

Abstract:

A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is below about 40 degrees C., and the acyl chains of the diacylglycerol-PEG are greater than or equal to 14 carbons in length. Such liposome suspensions are useful for a variety of purposes, including the delivery of therapeutic agents.

Priority: US2000-745292 Applic. Date: 2000-12-20

Inventor: KELLER BRIAN CHARLES [US]; LASIC LEGAL REPRESENTATIVE ALE [US]


Patent No.: US6960346B2  Issued: 01/Nov/2005

Title: Vehicles for delivery of biologically active substances

Applicant/Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Application No.: 10/143144   Filing Date: 09/May/2002

Abstract:

A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.

Priority:

Inventor: SHUKLA ATUL J [US]; JOHNSON JAMES R [US]; SUN YICHUN [US]; COOPER ROBERT [US]; BORING GREGG [US]; SCRUGGS DAN [US]


Patent No.: US6964775B1  Issued: 15/Nov/2005

Title: Decorative cosmetic preparations

Applicant/Assignee: BIOTEC ASA

Application No.: 09/958056   Filing Date: 07/Jan/2002

Abstract:

Decorative cosmetic preparations that contain water-soluble beta-(1,3) glucans, which have intact beta-(1,3) side-chains and are free from repetitive beta-(1,6) linkages and a method of producing the same are disclosed.

Priority: DE19991017744 Applic. Date: 1999-04-20; WO2000EP03193 Applic. Date: 2000-04-11

Inventor: WACHTER ROLF [DE]; GRIESBACH UTE [DE]; ANSMANN ACHIM [DE]; FABRY BERND [DE]; ENGSTAD ROLF E [NO]


Patent No.: US6964783B1  Issued: 15/Nov/2005

Title: Non-solid composition for local application

Applicant/Assignee: NATURVEDA

Application No.: 10/009027   Filing Date: 01/Jul/2002

Abstract:

The invention concerns a composition, in particular a non-solid pharmaceutical composition for local application comprising, as active principle, at least glycerol or a concentrated solution of glycerol, saccharose, sorbitol or mannitol, the active principle concentration of said composition being osmotically active towards plasma.

Priority: WO1999FR01340 Applic. Date: 1999-06-08

Inventor: SHRIVASTAVA RAVI [FR]


Patent No.: US6965816B2  Issued: 15/Nov/2005

Title: PFN/TRAC system FAA upgrades for accountable remote and robotics control to stop the unauthorized use of aircraft and to improve equipment management and public safety in transportation

Applicant/Assignee: KLINE & WALKER, LLC

Application No.: 10/260525   Filing Date: 01/Oct/2002

Abstract:

This invention, a Protected Primary Focal Node PFN is a Trusted Remote Activity Controller TRAC and mobile communication router platform that provides accountable remote and robotics control to transportation vehicles by interfacing with the vehicles E/E systems. It connects each vehicle either on the earth's surface or near the earth's surface with application specific intranets for air, sea and land travel, via either host commercial servers or agency providers through wireless communication gateways and then further interfaces these vehicles in a larger machine messaging matrix via wireless and IP protocols to further coordinate movement assess and manage equipment use and impact on the world resources, societies infrastructure and the environment.

This filing focuses directly on PFN/TRAC System use to augment and upgrade public safety and security in the Airline Industry and restrict any unauthorized use of an aircraft. Additionally, this application and related filings teaches the PFN/TRAC System(TM) use for all vehicle platforms to increase safety and security in a free society like the United State of America. The other related filings instruct in the technology's use for robust and accountable remote control for personal applications, stationary equipment and standalone functions, and coordinates them and interfaces them within the communication matrix. The TRAC controller also performs translation and repeating functions across a wide variety of communication protocols to complete a more mobile flexible matrix or web.

This connected communication matrix of computers and humans provides an enhanced Human Machine Interfacing HMI scenario both locally and systemically in real-time for improve equipment management and world stability.

Priority: US20010325538P Applic. Date: 2001-10-01; US20010330085P Applic. Date: 2001-10-19

Inventor: WALKER RICHARD C [US]


Patent No.: US6967217B1  Issued: 22/Nov/2005

Title: Process and composition for enhancing the action of vitamin a on the cellular activity of an individual, and use of vitamin c

Applicant/Assignee: NATURA COSMETICO S.A

Application No.: 09/786057   Filing Date: 26/Jun/2001

Abstract:

The present invention refers to a process, a composition and the use of Vitamin C for enhancing the action of Vitamin A on the cellular activity of an individual. According to the invention, the association of Vitamin C to Vitamin A will be applied to said individual at a weight ratio ranging from 1:1 to about 10:1.

Priority: BR19980003936 Applic. Date: 1998-09-08; WO1999BR00072 Applic. Date: 1999-09-03

Inventor: ZUCCHETTI ROBERTO ALCANTARA MA [BR]; SOUZA SIMONI CHITARRA [BR]; SILVA LUCIANA VILLA NOVA [BR]


Patent No.: US6969521B1  Issued: 29/Nov/2005

Title: Aerosol insect repellent composition having low VOC content and method of applying same to the skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 09/724313   Filing Date: 28/Nov/2000

Abstract:

Disclosed is an aerosol insect repellent composition. The composition has (a) an amount of an insect repellent effective to repel insects when applied to the skin and (b) a cosmetically-acceptable vehicle in which to disperse and deliver the insect repellent active. The vehicle has (i) a VOC component capable of volatilizing upon exposure to a reduction in pressure for delivering the composition in an aerosol form, and (ii) a non-VOC component. The aerosol composition has a VOC content of not greater than about 55 wt. % based upon the weight of the aerosol composition. Further disclosed is a method of repelling insects from skin wherein the aerosol composition is applied to or sprayed on the skin.

Priority:

Inventor: GONZALEZ ANTHONY D [US]; PECHKO ANDREW H [US]; KALAFSKY ROBERT E [US]


Patent No.: US6972130B1  Issued: 06/Dec/2005

Title: Bioceramic compositions

Applicant/Assignee: ETEX CORPORATION

Application No.: 09/284436   Filing Date: 08/Jun/2000

Abstract:

The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.

Priority: US1996-729354 Applic. Date: 1996-10-16; US1996-729342 Applic. Date: 1996-10-16; WO1997US18528 Applic. Date: 1997-10-16

Inventor: LEE DOSUK D [US]; REY CHRISTIAN [FR]; AIOLOVA MARIA [US]; TOFIGHI ALIASSGHAR [US]


Patent No.: US6974582B2  Issued: 13/Dec/2005

Title: Cosmetic composition

Applicant/Assignee: AJINOMOTO CO., INC

Application No.: 10/155776   Filing Date: 28/May/2002

Abstract:

Herein is disclosed a cosmetic composition comprising, as active ingredients, one or more members selected from the group consisting of mono-N-acylarginines and cosmetic powders whose surfaces have been treated with a mono-N-acylarginine (Ingredient A) and one or more members selected from the group consisting of water-soluble polymers and alcohol-soluble polymers (Ingredient B), which cosmetic composition is excellent in conditioning effects such as moist feeling and voluminous feeling in the case of hair cosmetics and excellent in feelings upon use such as smoothening property and moist feeling without sticky feeling and occlusive feeling in the case of skin cosmetics.

Priority: JP20010171269 Applic. Date: 2001-06-06; JP20010336884 Applic. Date: 2001-11-01

Inventor: YAMATO NAOYA [JP]


Patent No.: US6974594B2  Issued: 13/Dec/2005

Title: Method of preparing biological materials and preparations produced using same

Applicant/Assignee: GAINFUL PLAN LIMITED

Application No.: 10/054914   Filing Date: 25/Jan/2002

Abstract:

Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a coating liquid comprising at least one active, a sugar polymer and a water soluble/miscible solvent

(ii) providing a quantity of microparticles comprising at least water soluble gel forming solid particles

(iii) fluidizing said quantity of microparticles within a processing chamber of a of a suitable apparatus to form a fluidized bed of said microparticles

(iv) spraying said coating liquid onto said fluidized bed from beneath the fluidized bed to coat said microparticles therewith under saturated moisture conditions

and (vi) allowing coated microparticles to dry, are described. Also described are compositions and uses.

Priority: AU2001PR02729 Applic. Date: 2001-01-25

Inventor: KO THOMAS S Y [AU]; AU YEUNG TERENCE P Y [AU]


Patent No.: US6974679B2  Issued: 13/Dec/2005

Title: Support with collagen base for tissue engineering and manufacture of biomaterials

Applicant/Assignee: COLETICA

Application No.: 10/364223   Filing Date: 10/Feb/2003

Abstract:

The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.

Priority: FR20000006748 Applic. Date: 2000-05-26; FR20000006743 Applic. Date: 2000-05-26; US2000-616282 Applic. Date: 2000-07-14; US2000-616526 Applic. Date: 2000-07-14

Inventor: ANDRE VALERIE [FR]; ABDUL MALAK NABIL [FR]; HUC ALAIN [FR]


Patent No.: US6974796B1  Issued: 13/Dec/2005

Title: Therapeutic compositions for treatment of a damaged tissue

Applicant/Assignee:

Application No.: 09/639859   Filing Date: 16/Aug/2000

Abstract:

The present invention relates to a therapeutic composition and uses thereof for treatment of damaged tissue, wherein the composition comprises at least one extracellular matrix compound, at least one polar surface active lipid, and a plurality of amino acids having a molar ratio which is characteristic of human breast milk protein

and further comprises a fatty acid, gamma-amino butyric acid or L-carnitine.

Priority: US19990149338P Applic. Date: 1999-08-17

Inventor: GIRSH LEONARD S [US]


Patent No.: US6974799B2  Issued: 13/Dec/2005

Title: Compositions containing mixtures of tetrapeptides and tripeptides

Applicant/Assignee: SEDERMA S.A.S

Application No.: 10/731921   Filing Date: 10/Dec/2003

Abstract:

Pharmaceutical, personal care and cosmetic compositions containing a tripeptide and a tetrapeptide are useful for treating visible signs of aging including wrinkles, stretch marks and dark circles.

Priority: WO2003EP14019 Applic. Date: 2003-11-17

Inventor: LINTNER KARL [FR]


Patent No.: US6974804B2  Issued: 13/Dec/2005

Title: Esters

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 09/982077   Filing Date: 17/Oct/2001

Abstract:

Acylated cellobiose compounds (CHME) which satisfy the formula

wherein X represents an acyl group (R-CO-) or H, Z represents an acyl group (R'-CO-) or H and not more than a minority of X+Z residues represent H, R represents a saturated or unsaturated, linear or branched chain hydrocarbon residue of 5 to 31 carbon atoms and R' represents a residue, different from R, which is: (i) a saturated or unsaturated, linear or branched chain hydrocarbon residue of 1 to 31 carbon atoms, or (ii) an aromatic hydrocarbon residue, or (iii) a cycloaliphatic hydrocarbon, each optionally substituted. CHME esters are particularly suited to thickening or structuring a water-immiscible liquid, for example, a phase in a cosmetic formulation, such as antiperspirant or deodorant formulations, eg water in oil emulsions and especially translucent ones.

Priority: GB20000025437 Applic. Date: 2000-10-17

Inventor: FRANKLIN KEVIN RONALD [GB]; HOPKINSON ANDREW [GB]; WEBB NICHOLAS [GB]; WHITE MICHAEL STEPHEN [GB]


Patent No.: US6976281B2  Issued: 20/Dec/2005

Title: Medicinal cushion, in particular anti-decubitus cushion

Applicant/Assignee: INTECH THUERINGEN GMBH

Application No.: 10/415856   Filing Date: 03/Sep/2003

Abstract:

A medical cushion ( 1 ), in particular an anti-decubitus cushion, is in particular multicellular and is distinguished in that the cushion is equipped, at least in the area where skin contact ( 6 ) occurs, with an active membrane ( 3 ) based on a skin-compatible matrix ( 4 ) into which a molecular sieve is mixed. This molecular sieve is charged with at least one active substance (Z, Z1, Z2), and the molecular sieve/active substance adduct ( 5 ) releases the active substance when the active membrane comes into skin contact ( 6 ) in conjunction with the transpiration of the skin.

Priority: DE20011042876 Applic. Date: 2001-09-03; WO2002DE02916 Applic. Date: 2002-08-08

Inventor: SCHUNK WERNER [DE]; BRUDER MICHAEL [DE]; KRAUSE KARL-HEINZ [DE]; MERKMANN GERHARD [DE]; VORTKORT JOERG [DE]


Patent No.: US6979440B2  Issued: 27/Dec/2005

Title: Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric

Applicant/Assignee: SALVONA, LLC

Application No.: 10/222054   Filing Date: 16/Aug/2002

Abstract:

The present invention is a controlled delivery system that can be incorporated in hair, skin, and fabric care products such as shampoos, conditioners, hair styling products, lotions, creams, liquid laundry detergents, fabric softener, and other hair, skin, and fabric care products to effectively deliver a broad range of active agents and sensory markers onto the hair, skin, and fabric. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance "burst" upon blow drying the hair, ironing the fabric, or other types of heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns.

The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto hair, skin, and fabric. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.

Priority: US2001-771752 Applic. Date: 2001-01-29

Inventor: SHEFER ADI [US]; SHEFER SAMUEL DAVID [US]


Patent No.: US6979454B1  Issued: 27/Dec/2005

Title: Biologically active composition

Applicant/Assignee: JAGOTEC AG

Application No.: 09/155642   Filing Date: 02/Oct/1998

Abstract:

A biologically active stick composition comprising a biologically active agent dissolved in a carrier system including an unsaturated fatty acid alcohol in mutual dissolution with an alkylene glycol as a solvent for said biologically active agent and a stiffening agent therefor, said stiffening agent imparting stick consistency to the composition, said alkylene glycol preferably being present in an amount of more than 12%. The composition can be prepared by dissolving the active agent in the solvent, combining the solution with the stiffening agent and shaping the formulation into a stick. The composition is especially intended for use as a medicament, preferably in the treatment of dermatological conditions, where it has been found to possess outstanding bioavailability properties.

Priority: SE19960001665 Applic. Date: 1996-04-30; WO1997SE00721 Applic. Date: 1997-04-29

Inventor: LINDAHL AAKE [SE]; BRYLAND RICKARD [SE]


Patent No.: US6979670B1  Issued: 27/Dec/2005

Title: Matrix protein compositions for grafting

Applicant/Assignee: BIORA BIOEX AB

Application No.: 09/521907   Filing Date: 09/Mar/2000

Abstract:

Enamel matrix, enamel matrix derivatives and/or enamel matrix proteins are used in the preparation of a pharmaceutical composition for promoting the take of a graft, e.g. in soft tissue such as skin or mucosa or mineralized tissue such as bone.

Priority: DK19990000337 Applic. Date: 1999-03-10; US19990134954P Applic. Date: 1999-05-19

Inventor: LYNGSTADAAS STAALE PETTER [NO]; GESTRELIUS STINA [SE]


Patent No.: US6982248B2  Issued: 03/Jan/2006

Title: Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue

Applicant/Assignee: AMYLIN PHARMACEUTICALS, INC

Application No.: 09/851738   Filing Date: 09/May/2001

Abstract:

Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like peptide-1. The invention relates to both the method and compositions for such treatment.

Priority: US1999-302596 Applic. Date: 1999-04-30; US19980103498P Applic. Date: 1998-10-08

Inventor: COOLIDGE THOMAS R [US]; EHLERS MARIO R W [US]


Patent No.: US6982284B1  Issued: 03/Jan/2006

Title: Compositions and methods for modification of skin lipid content

Applicant/Assignee: APPLIED GENETICS INCORPORATED DERMATICS

Application No.: 10/070466   Filing Date: 07/Mar/2002

Abstract:

The topical use of ursolic acid compounds to alter the lipid content of mammalian skin is disclosed. The compounds can be encapsulated in liposomes and administered in this form to the skin in, for example, a lotion or a gel. The compounds are effective in, among other things, reducing the effects of aging, photoaging, and skin atrophy, including skin atrophy resulting from the topical use of retinoids and/or steroids. Compositions comprising a ursolic acid compound in combination with another therapeutically active topical compounds, such as, a retinoid or a steroid, are also disclosed.

Priority: US19990153378P Applic. Date: 1999-09-10; WO2000US24659 Applic. Date: 2000-09-08

Inventor: BROWN DAVID A [US]; YAROSH DANIEL B [US]


Patent No.: US6986896B2  Issued: 17/Jan/2006

Title: Method of treating fungal conditions of the skin

Applicant/Assignee: BRADLEY PHARMACEUTICALS, INC

Application No.: 10/370666   Filing Date: 20/Feb/2003

Abstract:

Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or around a nail of a patient in need of treatment.

Priority: US2002-103213 Applic. Date: 2002-03-20

Inventor: BHAGWAT DILEEP [US]; GLASSMAN BRADLEY P [US]; GLASSMAN DANIEL [US]


Patent No.: US6989106B2  Issued: 24/Jan/2006

Title: Process for the preparation of polymeric condensates and their use

Applicant/Assignee: BAYER AKTIENGESELLSCHAFT

Application No.: 10/457262   Filing Date: 09/Jun/2003

Abstract:

A process for the preparation of polymeric condensates, wherein the reaction mixture is fed at least once during the condensation reaction through a zone of high energy density which has an energy density of at least 10<5 >J/m<3>.

Priority: DE20021025349 Applic. Date: 2002-06-07; DE20031010287 Applic. Date: 2003-03-10

Inventor: MEISEL KARLHEINRICH [DE]; OBENDORF LARS [DE]; BOEHMER BRANISLAV [DE]; THIELE BERND [DE]; SPANIOL ARMIN [DE]; FUCHS DIETMAR [DE]; RENNER GERD-FRIEDRICH [DE]; HUEBBE THOMAS [DE]


Patent No.: US6989149B2  Issued: 24/Jan/2006

Title: Delivery of reactive agents via self emulsification for use in shelf-stable products

Applicant/Assignee:

Application No.: 09/764561   Filing Date: 17/Jan/2001

Abstract:

Disclosed are treatment compositions comprising a liquid emulsifiable concentrate which comprises a chemically unstable reactive agent wherein the reactive agent is comprised of one or more reactive groups of the electrophilic, nucleophilic or protected thiol type, a water immiscible solvent, one or more surfactants, which is usable upon dilution within a separate aqueous composition to form a micro- or macro-emulsion in-situ immediately prior or simultaneous to application to the substrate and wherein the reactive agent is chemically shelf stable. Also disclosed are methods for treating amino acid based substrates, and methods for bleaching, coloring and conditioning hair with these treatment compositions.

Priority:

Inventor: GLENN JR ROBERT WAYNE [GB]; DUNBAR JAMES CHARLES [GB]; TADROS THARWAT [GB]


Patent No.: US6989150B1  Issued: 24/Jan/2006

Title: Cosmetic preparation of active substances with a synergistically increased radical protection factor

Applicant/Assignee: COTY B.V

Application No.: 10/049770   Filing Date: 19/Feb/2002

Abstract:

The inventive cosmetic preparation of active substances, as such as well as in combination with other active substances, protects the skin against free radical aggression in a particularly effective manner. The preparation consists of a bark extract of quebracho blanco which contains at least 90 wt. % of proanthocyanidine oligomers, a silkworm extract which contains the peptide cecropine, amino acids and a vitamin mixture, a non-ionic, cationic or anionic hydro-gel, phopholipids, a yeast disintegration product and cyclodextrines. The inventive preparation can contain additional active substances such as plant extracts of acerola, sea weed, citrus, bitter orange, cherry, papaya, tea, coffee beans, skin tree and angelica. The preparations have synergistically increased radical protection factors of up to 10,000. Cosmetic compositions containing said preparations have radical protection factors of between 40 and 400 according to the portion of the preparation.

Priority: WO1999DE03295 Applic. Date: 1999-10-08

Inventor: GOLZ-BERNER KARIN [DE]; ZASTROW LEONHARD [DE]


Patent No.: US6989417B2  Issued: 24/Jan/2006

Title: Polymeric thickeners for oil-containing compositions

Applicant/Assignee: LANDEC CORPORATION

Application No.: 09/810920   Filing Date: 16/Mar/2001

Abstract:

Thickeners for oil-containing compositions, particularly cosmetic and personal care compositions, are side chain crystalline polymers which are uniformly dispersed as a crystallized solid in the oil.

Priority: US1999-398377 Applic. Date: 1999-09-17

Inventor: BITLER STEVEN P [US]; TAFT DAVID D [US]


Patent No.: US6991781B2  Issued: 31/Jan/2006

Title: Delivery of reactive agents via bi-layer structures for use in shelf-stable products

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/764560   Filing Date: 17/Jan/2001

Abstract:

Disclosed are treatment composition, comprising an aqueous continuous phase

a reactive component comprising a reactive agent and a water immiscible solvent, wherein the water immiscible solvent solubilizes the reactive agent

and one or more surfactants wherein the surfactants emulsify the reactive component in the aqueous phase to form a bi-layer emulsion. Also disclosed are methods for treating amino acid based substrates, and methods for bleaching, coloring and conditioning hair with these treatment compositions.

Priority:

Inventor: GLENN JR ROBERT WAYNE [GB]; DECKNER GEORGE ENDEL [US]; CAIE ANDREW JAMES [GB]


Patent No.: US6994844B2  Issued: 07/Feb/2006

Title: Photostable UV-screening compositions comprising dibenzoylmethane/diarylbutadiene compounds

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/463326   Filing Date: 18/Jun/2003

Abstract:

Topically applicable, photostable cosmetic/dermatological UV-screening compositions comprise (a) at least one photolabile UV-screening dibenzoylmethane compound and (b) a dibenzoylmethane photostabilizing amount of at least one 4,4-diarylbutadiene compound, formulated into a topically applicable, cosmetically/dermatologically acceptable support therefor

the weight ratio of the 4,4-diarylbutadiene compound(s) to the diarylbutadiene compound(s) is characteristically greater than 2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.

Priority: FR20000016518 Applic. Date: 2000-12-18; WO2001FR03635 Applic. Date: 2001-11-20

Inventor: CANDAU DIDIER [FR]


Patent No.: US6994846B2  Issued: 07/Feb/2006

Title: Composition for cosmetic or dermatological use containing a triblock polymer

Applicant/Assignee: L'OREAL

Application No.: 10/197555   Filing Date: 18/Jul/2002

Abstract:

The present patent application relates to a cosmetic and/or dermatological composition comprising at least one aqueous phase including at least one water-soluble or water-dispersible polymer, of triblock structure B-A-B in which A is an ionic water-soluble polymer block and B is a hydrophobic polymer block, the amount of polymer block A being greater than or equal to 50% of the total weight of the triblock polymer.

Priority: FR20010009614 Applic. Date: 2001-07-18

Inventor: L ALLORET FLORENCE [FR]


Patent No.: US6994863B2  Issued: 07/Feb/2006

Title: Pharmaceutical and cosmetic carrier and composition for topical application

Applicant/Assignee: FOAMIX LTD

Application No.: 10/392071   Filing Date: 19/Mar/2003

Abstract:

A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.

Priority: US2000-653267 Applic. Date: 2000-08-31; US20000216162P Applic. Date: 2000-07-03; WO2001IL00025 Applic. Date: 2001-01-10; IL20000133968 Applic. Date: 2000-01-10; IL20000133969 Applic. Date: 2000-01-10; IL20000137051 Applic. Date: 2000-06-27; IL20000137052 Applic. Date: 2000-06-27; IL20020150644 Applic. Date: 2002-07-17; US2000-526509 Applic. Date: 2000-03-16

Inventor: EINI MEIR [IL]; TAMARKIN DOV [IL]


Patent No.: US6995164B2  Issued: 07/Feb/2006

Title: Methods of treating tumors

Applicant/Assignee: RHODE ISLAND HOSPITAL

Application No.: 10/301263   Filing Date: 21/Nov/2002

Abstract:

The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.

Priority: US2000-730666 Applic. Date: 2000-12-06; US19990169122P Applic. Date: 1999-12-06; US19990169127P Applic. Date: 1999-12-06; US19990169128P Applic. Date: 1999-12-06

Inventor: CALABRESI PAUL [US]; DARNOWSKI JAMES [US]


Patent No.: US6998369B2  Issued: 14/Feb/2006

Title: Antimicrobial composition

Applicant/Assignee: ECOLAB INC

Application No.: 10/413635   Filing Date: 14/Apr/2003

Abstract:

A method for antimicrobial treatment comprising applying to microbes a composition containing a diluting solvent (e.g., water), an antimicrobially-active solvent having a density different from the density of the diluting solvent, and an optional cosolvent, surfactant, or additional antimicrobial agent, wherein the amount of antimicrobially-active solvent or additional antimicrobial agent is sufficiently high and the amount of cosolvent or surfactant is sufficiently low so that the composition will provide greater than a 1-log order reduction in the population of bacteria or spores of Bacillus cereus within 10 seconds at 60 DEG C. Preferred methods of the invention employ compositions containing an additional antimicrobial agent such as peroxyacetic acid. Compositions for use in the method can be prepared as concentrates, and used full strength or in diluted form.

Priority: US2001-794790 Applic. Date: 2001-02-27; US2000-560170 Applic. Date: 2000-04-28; US2000-641775 Applic. Date: 2000-08-18

Inventor: HEI ROBERT D P [US]; WEI GUANG-JONG J [US]; HALSRUD DAVID A [US]; SMITH KIM R [US]; PODTBURG TERESA C [US]


Patent No.: US6998385B2  Issued: 14/Feb/2006

Title: Cyclosporine analogue mixtures and their use as immunomodulating agents

Applicant/Assignee: ISOTECHNIKA INC

Application No.: 10/274255   Filing Date: 17/Oct/2002

Abstract:

The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISATX247, and derivatives thereof. Mixtures of ISATX247 isomers exhibit a combination of enhanced potency and reduced toxicity over the naturally occurring and presently known cyclosporins. ISATX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of stereoselectivity.

The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture.

Priority: US20010346201P Applic. Date: 2001-10-19; US20020370596P Applic. Date: 2002-04-05

Inventor: NAICKER SELVARAJ A [CA]; YATSCOFF RANDALL W [CA]; FOSTER ROBERT T [CA]


Patent No.: US6998387B1  Issued: 14/Feb/2006

Title: Human appetite control by glucagon-like peptide receptor binding compounds

Applicant/Assignee: AMYLIN PHARMACEUTICALS, INC

Application No.: 09/646433   Filing Date: 24/Nov/2000

Abstract:

A composition including a compound which binds to a receptor for glucagon-like peptide-1 and a pharmaceutical carrier. The amount of the compound present is effective to control appetite in a human. Also disclosed is a method for controlling appetite and for reducing food intake in a human by administering to the human a composition comprising a compound which binds to a receptor for glucagon-like peptide-1 and a pharmaceutical carrier.

Priority: US19980078544P Applic. Date: 1998-03-19; WO1999US05571 Applic. Date: 1999-03-16

Inventor: GOKE BURKHARD [DE]; BEGLINGER CHRISTOPH [CH]; COOLIDGE THOMAS R [US]


Patent No.: US7001355B2  Issued: 21/Feb/2006

Title: Skin care device

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY AND MATSUSHLTA ELECTRIC WORKS, LTD THE PROCTER & GAMBLE COMPANY

Application No.: 10/460911   Filing Date: 13/Jun/2003

Abstract:

Disclosed is a device for penetrating a skin active agent to the human body via the skin by the use of an ultrasound applying apparatus which applies ultrasound to the human body via the skin, comprising: (1) composition comprising: (a) safe and effective amount of the skin active agent

(b) a viscosifying agent that provides the composition a viscosity of from about 1,000 mPas to about 1,000,000 mPas

(c) from about 0.1% to about 30% of a water-soluble humectant

and (d) an aqueous carrier

wherein the composition is substantially free of surfactants

and (2) the ultrasound applying apparatus comprising: (e) an application element for applying to the skin ultrasound at a frequency of from about 3 MHz to about 10 MHz and an intensity of from about 0.1 W/cm<2 >to about 2 W/cm<2>

and (f) a control element for controlling application conditions of the application element.

Priority: JP20020012143 Applic. Date: 2002-01-21; WO2003JP00455 Applic. Date: 2003-01-21

Inventor: NUNOMURA MAHITO [JP]; OBA TAKAFUMI [JP]; MATSUMURA YUKO [JP]; NONAKA GEN [JP]; TANAKA HIDEKAZU [JP]


Patent No.: US7001592B1  Issued: 21/Feb/2006

Title: Sunscreen compositions and methods of use

Applicant/Assignee: AQUEA SCIENTIFIC CORPORATION

Application No.: 11/076565   Filing Date: 08/Mar/2005

Abstract:

The invention encompasses additives for addition to a bodywash, where the additives contain one or more sunscreens, and where a bodywash which contains the additive imparts to the skin an SPF of at least about 2, in some cases at least about 5, or 10, or 15. Also described are methods of making and using the additives.

Priority: US20050648961P Applic. Date: 2005-01-31

Inventor: TRAYNOR DANIEL HENRY [US]; MARKOWITZ STEVEN M [US]; COMPTON DAVID L [US]; TRAYNOR HENRY G [US]; DULAK MICHAEL [US]


Patent No.: US7001594B1  Issued: 21/Feb/2006

Title: Scalp cosmetic compositions and corresponding methods of application to provide scalp moisturization and skin active benefits

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/685850   Filing Date: 10/Oct/2000

Abstract:

Disclosed are topical leave-on cosmetic compositions, including packaged leave-on compositions, for direct application to the scalp, comprising a) from about 40% to about 99% by weight of a volatile liquid, b) from about 0.005% to about 20% by weight of a skin active agent, and c) from about 0.1% to about 20% by weight of a moisturizing material, preferably a liquid humectant. The composition is a leave-on formulation that is substantially free of cleansing surfactants and is applied directly to the scalp. Also disclosed are methods of treating the scalp by directly applying the topical composition to the scalp. It has been found that the compositions and methods of the present invention can provide improved scalp moisturization and improved deposition of an anti-dandruff or other skin active agent on the skin, without unduly affecting hair cosmetics.

Priority:

Inventor: PEFFLY MARJORIE MOSSMAN [US]; MARCHETTA ANTHONY RAYMOND [US]


Patent No.: US7001604B2  Issued: 21/Feb/2006

Title: Cosmetic composition

Applicant/Assignee: KUBS KOSMETIK GMBH & CO. KG

Application No.: 10/203993   Filing Date: 09/Dec/2002

Abstract:

A cosmetic composition, especially for use on aged and/or stressed skin is described, whereby apart from water at least one substance forming lamellar structures with water is present in the composition. The composition further cont

Priority: WO2001DE00615 Applic. Date: 2001-02-19; DE20001008850 Applic. Date: 2000-02-25

Inventor: ALBRECHT MARTIN [DE]; GHYCZY MIKLOS [DE]


Patent No.: US7001613B2  Issued: 21/Feb/2006

Title: Skin friendly active substance patch for transdermal administration of hyperemic active substances

Applicant/Assignee: BEIERSDORF AG

Application No.: 10/436542   Filing Date: 12/May/2003

Abstract:

An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and compris

Priority: DE20001056009 Applic. Date: 2000-11-11; WO2001EP12605 Applic. Date: 2001-10-31

Inventor: RADLOFF DETLEV [DE]; WASNER MATTHIAS [DE]


Patent No.: US7005557B2  Issued: 28/Feb/2006

Title: Film-forming compositions for protecting skin from body fluids and articles made therefrom

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 09/898880   Filing Date: 03/Jul/2001

Abstract:

The present invention relates to a film-forming barrier composition useful for protecting the skin from body fluids, such as urine, feces, menses. The composition comprises a skin conditioning agent, a viscosity enhancing agent and an oleophilic film-forming agent. Optionally, the lotion may comprise skin care ingredients for treating or maintaining skin health. The composition may be applied to the skin by suitable delivery vehicles, such as absorbent articles or components thereof, sheet materials, pads, bandages, sponges, foam pads, pumps, sprays, depending on the viscosity of the composition.

Priority:

Inventor: KLOFTA THOMAS JAMES [US]; STAUDIGEL JAMES ANTHONY [US]; DECKNER GEORGE ENDEL [US]


Patent No.: US7008618B1  Issued: 07/Mar/2006

Title: Water soluble monomers and polymers for protecting substrates from ultraviolet light

Applicant/Assignee: NALCO COMPANY

Application No.: 10/290978   Filing Date: 08/Nov/2002

Abstract:

A UV-protective composition for treating substrates comprising one or more water-soluble, cationic, UV-absorbing polymers, wherein the cationic, UV-absorbing polymers are prepared by polymerizing one or more vinyl, allyl or acrylic monomers with one or more vinyl or acrylic monomers that absorb ultraviolet light radiation having a wavelength of about 200 to about 420 nm and a method of treating substrates.

Priority:

Inventor: HESSEFORT YIN Z [US]; MORRIS JOHN D [US]; CARLSON WAYNE M [US]; WEI MINGLI [US]; QUADIR MURAT [US]; BRAMMER JR LARRY E [US]


Patent No.: US7008627B1  Issued: 07/Mar/2006

Title: Use of complexes for the preparation of compositions for the treatment of sensitive skin, preparation process and hypoallergenic compositions

Applicant/Assignee: JOHNSON & JOHNSON CONSUMER FRANCE

Application No.: 09/994165   Filing Date: 06/Nov/2001

Abstract:

This invention relates to new dermocosmetic and pharmaceutical compositions which are useful for improving and treating hyperreactive skin conditions and more generally allergic-type reactions and/or intolerance phenomena, whether they are caused by external factors or factors intrinsic to the individual. The compositions of this invention preferably contain an anti-radical, in anti-inflammatory and an anti-allergic activity for the treatment of sensitive and/or allergic skin.

Priority: FR19960012821 Applic. Date: 1996-10-22; US1999-293111 Applic. Date: 1999-04-16; WO1997IB01318 Applic. Date: 1997-10-21

Inventor: CASTELLI DOMINIQUE [FR]; RIES GERD [DE]; FRITEAU LAURENCE [FR]; BOUSIGNIERE ELISABETH [FR]; FREDON LAURENT [FR]


Patent No.: US7008628B2  Issued: 07/Mar/2006

Title: End modified thermal responsive hydrogels

Applicant/Assignee: MADASA LLC

Application No.: 10/007184   Filing Date: 13/Nov/2001

Abstract:

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer

and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosifies in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

Priority: US1999-368440 Applic. Date: 1999-08-04; US19980095330P Applic. Date: 1998-08-04; US19980097741P Applic. Date: 1998-08-24

Inventor: RON EYAL S [US]; BROMBERG LEV [US]; TEMCHENKO MARINA [US]


Patent No.: US7012049B2  Issued: 14/Mar/2006

Title: MULTIPHASE AQUEOUS CLEANSING COMPOSITION

Applicant/Assignee: CLARIANT INTERNATIONAL LTD CLARIANT FINANCE (BVI) LIMITED

Application No.: 10/811362   Filing Date: 26/Mar/2004

Abstract:

The present invention relates to a multiphase aqueous cleansing composition for cleansing human skin and hair, which when agitated forms a single application phase, and when left standing, the composition rapidly returns to an appearance having at least two visibly distinct aqueous phases. The multiphase aqueous cleansing composition of the present invention provides an esthetically interesting and useful cleansing composition for use as a body wash, shower gel, foam bath or shampoo. The aqueous multiphase cleansing composition comprises: a surfactant comprising a surfactant or salt thereof

one or more co-surfactants

a humectant

and a salt, wherein the cleansing composition is essentially free of a thickener or a detergent builder.

Priority:

Inventor: LITTAU CHERYL [US]; HENNING TORSTEN [DE]; PORTER SANDRA [US]; COOPER SAM [US]


Patent No.: US7012093B2  Issued: 14/Mar/2006

Title: Multiple fluorescent natural dye compound from a marine organism and method of use thereof

Applicant/Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Application No.: 10/962475   Filing Date: 13/Oct/2004

Abstract:

The present invention provides a novel compound multiple fluorescent natural dye from a marine organism Holothuria Scabra having a chemical structure of of Si-O-R type wherein silica matrix is an integral part of the compound, taking part in the metabolism of the animal, wherein R being an organic moiety and also provides a composition containing the compound having various applications

also a process of extraction, purification and characterization of the novel multiple fluorescent